PMID
int64 35.7M
36.4M
| Title/Abstract
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|---|---|---|---|
36,304,790
|
pfo closur pulmonari valv intervent patient hypoxemia due right left intracardiac shunt four patient pulmonari valv pv diseas patent foramen oval pfo present dyspnea exert work reveal hypoxemia secondari right left intracardiac shunt demonstr correct primari culprit right heart overload lesion via pv replac enabl safe pfo repair resolut hypoxemia
|
D011664;D054092;D006348
|
T061;T019;T023
|
36,304,787
|
effect glucagon like peptid receptor agonist semaglutid improv sarcopen obes obes mice modul skelet muscl metabol studi aim investig effect semaglutid skelet muscl metabolom
|
D000067757;D055948
|
T047;T192
|
36,304,779
|
construct stomach cancer lesion detect combin drug therapi base artifici intellig number stomach cancer sc patient increas sharpli everi year gastroscop common method check stomach relat diseas bulg lesion stomach encount gastroscopi due chang eat habit enhanc health awar wide applic gastroscopi detect rate cure rate tumor signific improv certain clinic valu earli diagnosi treatment earli sc paper base background artifici intellig imag segment technolog use analyz process detect result sc judg effect drug treatment total gastric bulg lesion investig patient one year period also analyz age lesion locat size patholog type tumor detect result patient experi show among case submucos bulg lesion detect rate young group middl age group elder group respect among middl age peopl age highest detect rate incid gastric polyp similar differ age group age rate fundic gland polyp increas incid sc relat age patient patholog type incid sc middl age elder peopl signific higher young peopl sc common cardia gastrointestin stromal tumor common submucos protrus
|
D013274
|
T191
|
36,304,778
|
metadecomposit clinic valu assess use aeeg sever neonat hyperbilirubinemia amplitud integr electroencephalographi aeeg effect simpl mean continu eeg monitor besid neonat bed use predict earli brain injuri prognosi evalu neonat hyperbilirubinemia paper summar random control studi meta analyz valu aeeg evalu neonat hyperbilirubinemia acut bilirubin encephalopathi literatur search health interest scienc engin comput medic databas wanfang medicin pubm databas medic inform literatur aeeg evalu clinic valu neonat sever hyperbilirubinemia use revman softwar select metadecomposit experiment result show serum total bilirubin signific higher normal newborn aggrav condit serum express higher higher aeeg effect enhanc detect rate suffer help suffer receiv therapi soon possibl ensur prognosi children
|
D051556;D001927
|
T047
|
36,304,777
|
effect remimazolam combin esketamin anesthesia circulatori respiratori function painless gastroenteroscopi investig effect appli remimazolam combin esketamin anesthesia painless gastroenteroscopi patient circulatori respiratori function
|
D015742;D000758
|
T061;T121;T109
|
36,304,776
|
character clinic symptom cervic spondylot myelopathi base dki imag paramet ratio recent year peopl live condit signific improv lifestyl diversifi howev incid various diseas also increas includ cervic spondylot myelopathi csm spinal cord cervic spondylosi one spinal cord compress disord sever disabl account cervic spondylosi paper dki imag process technolog use studi symptom cervic spondylosi help help explor symptom caus onset cervic spondylosi longer period time period conserv treatment inevit requir longer period time clinic symptom cervic spinal cord compress main pain cervic spinal cord nerv compress ischemia hypoxia occur nerv sensit increas patient reflex neck muscl pain symptom caus degener patient intervertebr disc tissu degener facet joint ossif posterior longitudin ligament format spur posterior edg vertebr bodi condit becom complic import identifi characterist clinic symptom cervic spondylot myelopathi help patient cervic spondylosi recov paper identifi clinic symptom cervic spondylosi base paramet ratio method diffusion kurtosi imag dki current state diffus kurtosi imag treatment cervic spondylosi treatment oper introduc imag enhanc technolog medic imag use analyz disc herniat segment overflexion neutral hyperextens posit compar fa mk md valu spinal cord normal group patient group result show fa md mk valu patient group lower normal group find show md mk valu posit correl joa score reflect clinic symptom spinal cervic spondylosi worsen size number cervic intervertebr disc bulg hyperextens imag obvious number increas especi c c c intervertebr disc greater mobil highest respect
|
D013117;D013118;D055009
|
T047
|
36,304,775
|
artifici intellig deep learn assist rapid diagnosi covid chest radiograph imag survey artifici intellig ai appli success mani real life domain solv complex problem invent machin learn ml paradigm becom conveni research predict outcom base past data nowaday ml act biggest weapon covid pandem detect symptomat case earli stage warn peopl futurist effect observ covid blown global much short period shortag test facil delay test report address challeng ai effect appli produc fast well cost effect solut plenti research come ai base solut preliminari diagnosi use chest ct imag respiratori sound analysi voic analysi symptomat person asymptomat one forth ai base applic claim good accuraci predict chanc covid posit within short period plenti research work publish regard identif covid paper care examin present comprehens survey paper came various reput sourc springer ieee elsevi mdpi arxiv medrxiv paper select survey present candid work detect classifi covid use deep learn base model chest x ray ct scan imag hope survey cover work provid insight research communiti propos effici well accur solut fight pandem
|
D000086382;D000077321
|
T047;T066;T067
|
36,304,774
|
lymph node metastas detect use gd pcd novel multifunct contrast imag agent metabol magnet reson molecular imag axillari lymph node detect crucial stage prognosi lymph node metastat spread breast cancer current lymphoscintigraphi blue dye convent method local sentinel lymph node slns invas perform surgeri studi novel hybrid gadolinium oxid nanoparticl coat cyclodextrin base polyest high relax magnet reson molecular imag mrmi contrast agent ca twelv femal balbc mice random divid three group four mice group inject cell obtain metastasi lymph node diagnos use w vibe mri siemen prisma synthes gd pcd nanoparticl suitabl particl size rang nm much higher longitudin relax r gd pcd gd dota dotarem valu mm mm respect ident mr imag coron view subsequ obtain creat time intens curv right axillari lymph node measur contrast ratio cr peak cr qualit assess axillari lymph node five time point evalu subcutan inject contrast ratio axillari lymph node tumor mice exhibit cr peak gd pcd dotarem valu lymph node tumor respect furthermor lumbar aortic lymph node weak visibl origin coron imag conclus use gd pcd nanoparticl novel mrmi cas enabl high resolut detect lymph node metastasi mice potenti capabl breast cancer diagnost imag
|
D003287;D008279
|
T060;T170;T130;T059
|
36,304,773
|
influenc taijiquan exercis mental emot regul intellig medic big data analysi taijiquan train emphas relax mind bodi pay attent maintain peac mind minim impact extern interfer bodi make mind comfort studi main explor influenc taijiquan practic emot regul base intellig medic health big data analysi signific taijiquan develop improv posit emot middl age peopl maintain physic mental health expound two method data collect full collect increment collect studi psycholog test equip launch full amount histor data collect psycholog test equip onlin collect method general carri way increment collect subject exercis taijiquan three time week one hour time exercis content style taijiquan design workstat time subject ask engag regular physic exercis project spare time longitudin track comparison taijiquan intervent group particip taijiquan exercis intervent differ state mind emot regul strategi subject select voluntarili particip emot stroop color word use classic stroop paradigm replac emot nonemot word written differ color subject still task respond color experiment paradigm paper moder intens taijiquan project select line effect valu threshold theori exercis load studi effect exercis bodi shape cardiopulmonari function flexibl balanc abil bodi accord metabol theori movement balanc theori human bodi adapt environ experi signific differ taijiquan train group control group experi signific differ taijiquan train group control group p taijiquan signific effect improv student bodi shape cardiopulmonari function flexibl balanc mood
|
D026302;D000080103
|
T056;T041
|
36,304,772
|
effect gefitinib treatment necess prognosi nsclc patient earli egfr mutat investig need prognost impact gefitinib treatment patient earli stage epiderm growth factor receptor egfr mutat non small cell lung cancer nsclc
|
D002289;D008175;D000970
|
T121;T191;T109
|
36,304,749
|
effici model coronari arteri diseas diagnosi compar studi sever machin learn algorithm today industri world coronari arteri diseas cad one lead caus death earli detect time intervent prevent mani complic elimin reduc result mortal machin learn ml method one cut edg technolog use suitabl solut diagnos diseas
|
D003324
|
T047
|
36,304,748
|
nomogram predict cardiovascular diseas chronic obstruct pulmonari diseas patient cardiovascular diseas cvds common comorbid chronic obstruct pulmonari diseas copd increas risk hospit length stay death copd patient studi aim identifi predictor cvds copd patient construct predict model base predictor total copd patient nation health nutrit examin survey nhane involv cross section studi subject random divid train set n test set n differ manipul miss data compar via sensit analysi univari multivari analys employ screen predictor cvds copd patient perform predict model evalu via area curv auc accuraci sensit specif negat predict valu npv posit predict valu ppv calibr subgroup analysi perform patient use differ copd diagnosi method patient smoke smoke test set found male older age smoke histori overweight histori blood transfus histori heart diseas close relat higher level white blood cell wbc monocyt mono associ increas risk cvds copd patient higher level platelet plt lymphocyt lym associ reduc risk cvds copd patient predict model risk cvds copd patient establish base predictor includ gender age smoke histori bmi histori blood transfus histori heart diseas close relat wbc mono plt lym auc valu predict model ci train set ci test set predict model establish show good predict perform predict cvds copd patient
|
D002318;D029424;D006331
|
T047
|
36,304,741
|
deepfak adequ display emot studi deepfak facial emot express recent technolog advanc artifici intellig make easi creat deepfak hyper realist video imag video clip process creat fake video appear authent mani base swap face without consent person whose appear voic use emot inher human communic studi deepfak transfer emot express origin fake relev work conduct depth studi facial emot express deepfak use well known face swap base deepfak databas first extract photogram video analyz emot express origin fake version video record perform databas result show emot express adequ transfer origin record deepfak creat high variabl emot perform detect origin fake record indic perform emot express consid better deepfak generat detect
|
D001185;D005149
|
T033;T090;T073;T066
|
36,304,740
|
fast explain recommend model combin fine grain sentiment review data rapid develop e commerc recommend system becom one main tool assist user decis make enhanc user experi creat econom valu sinc difficult explain implicit featur generat matrix factor explain recommend system attract attent recent paper propos explain fast recommend model combin fine grain sentiment review data fser fast fine grain sentiment explain recommend innov construct user rate matrix user aspect sentiment matrix item aspect descript word frequenc matrix review base data three matric reconstruct matrix factor method reconstruct result user aspect sentiment matrix item aspect descript word frequenc matrix provid explan final recommend result experi yelp public comment dataset demonstr compar sever classic model propos fser model optim recommend accuraci rang lower spars higher train effici tensor model neural network model furthermor generat explanatori text diagram high interpret qualiti
|
D016571;D001290
|
T078;T055;T170;T041
|
36,304,739
|
classif marin mammal use train multilay perceptron neural network whale algorithm develop fuzzi system exist various sound differ natur unnatur sourc deep sea caus classif identif marin mammal intend identifi differ endang speci becom one topic interest research activist field paper first experiment data set creat use design scenario whale optim algorithm woa use train multilay perceptron neural network mlp nn howev due larg size data algorithm determin clear boundari explor extract phase next support shortcom fuzzi infer use new approach develop upgrad woa call fwoa fuzzi infer set fwoa control paramet well defin boundari two phase explor extract measur perform design categor addit use categor benchmark dataset five benchmark algorithm cvoa woa choa bwo pgo also use mlpnn train measur criteria concurr speed abil avoid local optim classif rate simul result obtain data set show respect classif rate mlpfwoa mlp cvoa mlp woa mlp choa mlp bwo mlp pgo classifi equal result mlp fwoa perform better algorithm
|
D014907;D016571
|
T015;T170
|
36,304,484
|
clinicopatholog featur inflammatori myofibroblast tumor breast inflammatori myofibroblast tumor imt mesenchym spindl cell tumour low malign potenti extrem rare breast lack typic imag clinic characterist imt easi misdiagnos oper report case year old woman present mass left breast ultrasound show well circumscrib lesion lower outer quadrant patient underw lumpectomi histopatholog reveal tumor compos fusiform cell inflammatori cell immunohistochemistri ihc show tumor cell posit vimentin alk bcl sma fish test demonstr alk p chromosom transloc alk posit final diagnosi breast imt render nonclass morpholog postop month follow evid show residu tumor recurr rare tumor breast imt could easili misdiagnos clinic patholog complet surgic resect tumor prefer risk recurr metastasi
|
D001943;D006104
|
T191;T046
|
36,304,475
|
compar b cell mediat immun respons patient type diabet receiv mrna inactiv covid vaccin acquir protect immun vaccin essenti especi patient type diabet vulner advers clinic outcom coronavirus diseas covid infect type diabet td associ immun dysfunct evalu impact td immunolog respons induc mrna bntb inactiv coronavac vaccin two common use covid vaccin studi consist two part part sera titr igg antibodi sever acut respiratori syndrom coronavirus sar cov alpha receptor bind domain rbd neutral capac antigen specif cd cd cell respons month vaccin compar bntb n coronavac n vaccine without td part time cours studi investig initi b cell respons induc bntb among vaccine n without td data show td impair cellular humor immun respons induc coronavac bntb td patient display reduct cd helper th differenti follow first dose howev initi defect rectifi second dose bntb result compar level memori cd cd cell anti rbd igg neutral antibodi healthi individu month vaccin henc td influenc effect covid vaccin depend platform find provid potenti mechan suscept develop advers outcom observ covid patient td receiv either coronavac one dose bntb
|
D014765;D003924;D000086382
|
T129;T047;T121;T067
|
36,304,473
|
describ immun factor associ hepat b surfac antigen loss nest case control studi chines sampl wuwei citi hepat b surfac antigen hbsag loss consid function cure chronic hepat b chb howev sever factor influenc hbsag loss
|
D006514;D019694
|
T129;T047;T121;T116
|
36,304,472
|
identif verif prognost valu cul colon adenocarcinoma cul gene compos exon associ cullin protein also e ligas close relat cell senesc apoptosi cell transform also play import role human cancer howev systemat pan cancer analysi perform explor role prognosi immun predict studi express cul colon adenocarcinoma coad investig determin prognosi valu first base cancer genom atlas tcga genotyp tissu express project gtex cancer cell line encyclopedia ccle tisidb databas potenti role cul differ tumor explor subsequ express cul coad explor verifi immunohistochemistri ihc furthermor mutat frequenc cul coad analyz prognost valu cul coad discuss addit nomogram construct prognost valu verifi follow data jiangmen central hospit final ppi network analysi explor potenti biolog function cul coad result show cul upregul tumor signific associ poor surviv time cul correl clinic stage immun landscap various tumor colorect cancer cul overexpress tumor tissu ihc mutat frequenc cul independ prognost factor colorect cancer nomogram construct effect predict perform extern databas prove prognost valu cul addit ppi network analysi show cul close relat fbxw pathway enrich analysi show cul main involv ubiquitin mediat proteolysi therefor studi provid comprehens understand potenti role cul differ tumor cul might prognost marker coad
|
D003110;D000230
|
T191
|
36,304,471
|
identifi enhanc driven subtyp specif prognost marker breast cancer base multi omic data breast cancer cancer high complex heterogen differ prognosi surviv among patient differ subtyp copi number variat cnvs within enhanc crucial driver tumorigenesi influenc express target studi perform integr approach identifi cna driven enhanc effect express target gene four breast cancer subtyp integr express data copi number data hkac data identifi cna driven enhanc gene pair cna driven enhanc lncrna pair basal like luma lumb subtyp respect reconstruct cnv driven enhanc lncrna mrna regulatori network subtyp function analysi show cna driven enhanc play import role progress breast cancer subtyp influenc p signal pathway ppar signal pathway system lupus erythematosus mapk signal pathway basal like luma lumb subtyp respect character potenti prognost valu target gene cnv driven enhanc lncrna mrna pair subtyp specif network identifi mum ac prognost biomark luma basal like subtyp respect higher express mum amplifi enhanc exhibit poorer prognosi luma patient lower express ac delet enhanc exhibit poorer surviv outcom basal like patient also identifi enhanc relat lncrna mrna pair prognost biomark includ ac mum luma ac plk lumb ac oaz basal like ac hcn subtyp final result highlight target gene cna driven enhanc enhanc relat lncrna mrna pair could act prognost marker potenti therapeut target breast cancer subtyp
|
D001943;D062085
|
T123;T191;T114
|
36,304,470
|
clinic cancer immunotherapi current progress prospect immun checkpoint therapi via pd antibodi shown excit clinic valu robust therapeut potenti clinic practic signific improv progress free surviv overal surviv follow surgeri radiotherapi chemotherapi target therapi cancer treatment enter age immunotherapi although cancer immunotherapi shown remark efficaci also suffer limit ira cytokin storm low respons rate etc review discuss basic classif research progress limit cancer immunotherapi besid combin cancer immunotherapi resist mechan analysi combin therapi give insight develop new anticanc immunotherapi strategi
|
D007167;D009369
|
T061;T191
|
36,304,469
|
host microrna decreas pediatr solid organ transplant recipi ebv post transplant lymphoprolif disord post transplant lymphoprolif disord ptld serious complic solid organ transplant predispos factor includ primari epstein barr virus ebv infect reactiv ebv recipi b cell decreas cell immun due immunosuppress previous studi ebv infect demonstr mark alter express host b cell microrna mir specif mir express uniqu suppress ebv b cell line ptld patient untransl region il determin target mir although ebv shown regul host mir express b cell lymphoma cell line express mir circul patient ebv associ ptld studi object studi determin chang mir express associ ebv ptld studi shown mir signific decreas ebvptld tumor addit mir includ mir also reduc ebvptld compar ebv ptld quantit level mir plasma extracellular vesicl ev nm determin nanoparticl track analysi pediatr recipi solid organ transplant ebv ptld match ebv ptld pediatr transplant recipi part nih sponsor clinic trial organ transplant children ctotc studi level mir reduc plasma extracellular vesicl ev ebv ptld group compar match control mir p plasma mir p ev mir p plasma ev signific reduc similar level mir detect plasma ev pediatr sot recipi import cell free mir contain within ev support ebv ptld tumor mir detect circul suggest ev contain mir may potenti target regul cell immun system develop diagnost mechanist potenti therapeut use mir ptld warrant
|
D020031;D008232;D016377;D035683
|
T061;T123;T191;T114;T047
|
36,304,468
|
genom transcriptom reveal new molecular mechan vibriosi resist fish infecti diseas caus dramat product declin econom loss fish aquacultur howev poor understand fish diseas resist sever hamper diseas prevent chines tongu sole cynoglossus semilaevi import econom flatfish suffer vibriosi use genom transcriptom experiment approach investig molecular genet mechan under fish vibriosi resist genom wide comparison reveal gene select sweep enrich glycosaminoglycan gag chondroitin sulfat cs dermatan sulfat ds metabol transcriptom analys priorit synerg gene express pattern pathway may lead increas csds content resist famili experiment evid show carbohydr sulfotransferas chst key enzym csds biosynthesi direct antibacteri activ best knowledg first report chst gene bactericid effect addit csds major compon extracellular matrix ecm select signatur fine tune gene express ecm receptor interact gene indic modif ecm structur enhanc barrier function furthermor function studi conduct cola encod collagen gene constitut ecm point may act cellular receptor vibrio pathogen thus play import role vibrio invas taken togeth find provid new insight molecular protect mechan under vibriosi resist fish offer crucial genom resourc resist germplasm breed infecti diseas control fish cultur
|
D014735;D014733
|
T047;T007
|
36,304,467
|
lactobacillus johnsonii yh play protect role endogen pathogen bacteria induc intestin dysfunct reconstruct gut microbiota mice expos high altitud intestin microbiota play import role maintain microecolog balanc gastrointestin tract various anim disturb intestin microbiota may lead prolifer potenti pathogen bacteria becom domin speci lead intestin immun disord intestin inflamm intestin diseas numer studi confirm high altitud exposur affect normal function intestin composit intestin microbiota howev still necessari reveal chang intestin microbiota high altitud exposur environ clarifi relationship prolifer potenti pathogen bacteria intestin injuri environ addit explor probiot may prevent effect intestin diseas
|
D000069196;D007410;D000069999;D035683
|
T123;T007;T114;T047;T001
|
36,304,466
|
character immun featur immunotherapi respons subtyp hepatocellular carcinoma base mitophagi mitophagi suggest involv tumor initi develop howev mitophagi heterogen hepatocellular carcinoma hcc associ immun status prognosi remain unclear differenti express gene deg identifi use express profil acquir cancer genom atlas tcga mitophagi relat subtyp identifi use consensusclusterplus softwar differ prognosi clinic characterist immun status includ immun cell infiltr immun function immun checkpoint gene express respons immunotherapi compar subtyp mitophagi relat gene signatur construct appli least absolut shrinkag select oper regress tcga cohort intern cancer genom consortium cohort cohort peke union medic colleg hospit util valid carbonyl cyanid chlorophenylhydrazon use induc mitophagi hcc cell line obtain mitophagi signatur real time polymeras chain reaction use experiment valid express model gene two mitophagi relat subtyp distinct prognos clinic characterist immun state biolog function pattern identifi base mitophagi relat deg subtyp show higher mitophagi relat deg express wors surviv outcom suppress immun function higher immun checkpoint gene express better respons immunotherapi indic subpopul hcc may benefit immun checkpoint blockad therapi immunotherapi risk model consist nine mitophagi relat gene construct perform confirm two valid cohort risk score independ risk factor even age sex tumor stage consid studi identifi two distinct mitophagi subtyp built mitophagi signatur uncov mitophagi heterogen hcc associ immun status prognosi find shed light treatment hcc especi immunotherapi
|
D006528;D008113
|
T191
|
36,304,465
|
prognost valu therapeut target myeloid deriv suppressor cell hematolog cancer success immunotherapeut approach hematolog cancer partial hamper presenc immunosuppress microenviron myeloid deriv suppressor cell mdsc key compon suppress environ frequent associ tumor cell surviv drug resist base morpholog phenotyp mdsc common subdivid polymorphonuclear mdsc pmn mdsc g mdsc monocyt mdsc mdsc character immunosuppress function phenotyp function prognost valu mdsc hematolog cancer intens studi howev therapeut target cell popul remain challeng need investig review summar prognost valu mdsc differ attempt target mdsc subtyp mdsc hematolog cancer discuss benefit challeng opportun use mdsc target approach aim enhanc anti tumor immun respons current use cellular non cellular immunotherapi
|
D000072737;D009369;D019337
|
T191;T025
|
36,304,464
|
emerg role lncrnas osteoarthr updat review osteoarthr oa preval joint diseas associ progress articular cartilag loss synovi inflamm subchondr sclerosi meniscus injuri molecular mechan under oa pathogenesi multifactori long non code rnas lncrnas non protein code rnas length nucleotid various function modul transcript protein activ well form endogen small interf rnas sirna microrna mirna spong emerg evid suggest lncrnas might involv pathogenesi oa open new avenu develop new biomark therapeut strategi purpos review summar current clinic basic experi relat lncrnas oa focus extens studi h gas malat xist hotair potenti translat valu lncrnas therapeut target oa also discuss
|
D062085;D010003;D002358
|
T123;T047;T024;T114
|
36,304,463
|
popul dermal langerin dendrit cell promot inflamm mous model atop dermat cutan dendrit cell dcs implic pathogenesi atop dermat ad howev specif role differ subset dcs well defin studi aim investig contribut langerhan cell lcs resid dermal langerin dcs r langerin ddcs newli infiltr inflammatori dermal langerin dcs langerin ddcs ad mous model induc topic applic mc result show deplet langerin ddcs dtr mice multipl diphtheria toxin dt inject signific reduc thymic stromal lymphopoietin tslp product lesion skin inflamm allevi howev deplet lcs r langerin ddcs nt result signific chang skin inflamm dta singl dt inject treat dtr mice compar wild type wt mice dt treat dtr wt chimer mice deplet bone marrow bm deriv langerin ddcs result mark decreas skin inflamm control pbs treat chimer mice dtr wt deplet r langerin ddcs show inflamm compar wt mice furthermor tslp contribut upregul langerin express bm deriv dcs promot matur langerin dcs summari present studi demonstr newli infiltr inflammatori dermal langerin dcs essenti ad develop local tslp product tslp promot product bm deriv langerin ddcs might maintain ad inflamm
|
D037241;D003876
|
T123;T047;T116
|
36,304,461
|
bacteroid fragili outer membran vesicl preferenti activ innat immun receptor compar parent bacteria releas bacteri membran vesicl bmvs becom recogn key mechan use pathogen commens bacteria activ innat immun respons host mediat immun outer membran vesicl omv produc gram negat bacteria harbor various immunogen cargo includ protein nucleic acid peptidoglycan composit omv strong influenc abil activ host innat immun receptor although various gram negat pathogen produc omv enrich immunogen cargo compar parent bacteria abil omv produc commens organ enrich immunostimulatori content recent becom known studi investig cargo associ omv produc intestin commens bacteroid fragili determin abil activ host innat immun receptor analysi b fragili omv reveal packag various biolog cargo includ protein dna rna lipopolysaccharid lps peptidoglycan cargo could enrich omv compar parent bacteria visual entri b fragili omv intestin epitheli cell addit abil b fragili omv transport bacteri rna peptidoglycan cargo caco epitheli cell use hek blue report cell line identifi b fragili omv could activ host toll like receptor tlr tlr tlr nucleotid bind oligomer domain contain protein nod wherea b fragili bacteria could induc activ tlr overal data demonstr b fragili omv activ broader rang host innat immun receptor compar parent bacteria due enrich biolog cargo abil transport cargo direct host epitheli cell find indic secret omv b fragili may facilit immun crosstalk host epitheli cell gastrointestin surfac suggest omv produc commens bacteria may preferenti activ host innat immun receptor mucos gastrointestin tract
|
D010457;D001441
|
T123;T007;T109
|
36,304,460
|
explor metabol scleroderma reveal opportun pharmacolog intervent therapi fibrosi recent evid indic alter energi metabol play critic role pathogenesi fibrot diseas studi suggest metabol reprogram involv glycolysi oxid phosphoryl oxpho cell lead enhanc generat energi biosynthesi aim studi assess molecular basi chang fibrot metabol system sclerosi scleroderma ssc highlight appropri target anti fibrot therapi
|
D012595;D012594
|
T047
|
36,304,459
|
character cardiac bradyarrhythmia associ lgi igg autoimmun enceph evalu character cardiac arrythmia associ lgi igg leucin rich glioma inactiv igg autoimmun enceph ae
|
D001919;D004660
|
T033;T047
|
36,304,458
|
cq apo complex new hallmark patholog viral hepat nonalcohol fatti liver diseas recent identifi high affin cq apo complex human arteri atherosclerot intima lesion human amyloid plaqu alzheim diseas brain defin common pathogenet pathway two divers diseas ie atherosclerosi dementia cq initi control protein classic complement cascad ccc occupi key role multipl acut chronic inflammatori tissu respons cq larg produc myeloid cell includ kupffer cell kcs subsequ secret circul inact preprotein bind partner apolipoprotein e apo produc kcs hepatocyt also secret circul regul essenti step lipid transport addit major sourc apo produc non liver cell includ immun cell multipl cell depend local tissu context initi ccc cascad cq must activ molecul vari oxid lipid amyloid fibril immun complex howev apo mute toward inact cq bind high affin activ form specif studi reveal apo ccc specif checkpoint inhibitor via format cq apo complex propos may aris multipl ccc associ diseas presenc indic ongo ccc activ turn liver examin cq apo complex human b c viral hepat nonalcohol fatti liver diseas nafld addit use multidrug resist gene knockout mdr ko mice model inflammatori liver diseas hepatocellular carcinoma hcc pathogenesi normal murin human liver kcs major cq produc cell type hepatocyt primari apo form cell type though cq apo complex rare nonexist howev signific number cq apo complex form mdr ko human viral hepat nafld around portal triad immun cell infiltr liver addit high number cq apo complex emerg human liver area extracellular lipid droplet across entir liver parenchyma nafld affect patient thus cq apo complex new patholog hallmark viral hepat b c nafld
|
D065626;D006528;D008113;D050197;D006525
|
T047;T191;T046
|
36,304,457
|
pembrolizumab chines patient advanc melanoma year follow keynot studi surviv general poor chines patient advanc melanoma high rate acral mucos melanoma limit therapeut option first analysi phase b keynot studi show second line pembrolizumab well toler clinic meaning antitumor activ chines patient advanc melanoma three year follow present elig patient chines descent unresect stage iiiiv melanoma progress first line therapi patient receiv pembrolizumab mgkg everi week cycl primari end point safeti object respons rate orr secondari end point includ durat respons dor progress free surviv pfs overal surviv os respons assess per recist v blind independ central review subgroup analys conduct melanoma subtyp braf pd l status acral melanoma patient enrol median follow durat time first dose data cutoff juli month iqr grade treatment relat advers event trae occur patient grade trae grade trae occur three patient discontinu pembrolizumab trae immun mediat hepat pneumonia arthriti immun mediat ae infus reaction occur grade orr ci complet respons partial respons median dor month rang median pfs month ci month pfs rate median os month ci month os rate median os patient known melanoma subtyp month acral month nonacr cutan month mucos melanoma among acral subgroup median os month pd l posit diseas month pd l negat diseas month braf wild type diseas month braf mutant diseas year follow second line pembrolizumab continu show manag safeti clinic meaning antitumor activ durabl respons chines patient advanc melanoma subgroup analysi suggest particular benefit pd l posit braf wild type acral melanoma although small subgroup size preclud definit conclus
|
D060890;D008545
|
T129;T191;T116
|
36,304,456
|
remodel bladder tumor immun microenviron mycobacteri speci chang cell envelop composit intraves bcg instil bladder tumor resect standard treatment non muscl invas bladder cancer howev alway effect frequent undesir side effect therefor new strategi improv clinic manag patient urgent need studi aim comprehens evalu bladder tumor immun microenviron profil intraves treatment panel mycobacteria variat cell envelop composit impact surviv use orthotop murin model identifi effect safer therapeut strategi tumor bear mice intraves treat panel bcg bruma cultur differ condit untreat tumor bear mice healthi mice also includ control mycobacteri treatment infiltr immun cell popul bladder analys flow cytometri provid evid mycobacteri treatment trigger strong immun infiltr bladder bcg induc higher global absolut infiltr bruma induc global immun microenviron strike differ two mycobacteri speci affect innat adapt immun compar bruma bcg treat mice exhibit robust infiltr cd cd cell skew toward effector memori phenotyp higher frequenc nkt cell neutrophilsgmdsc monocyt especi inflammatori subset higher cd em cd reg cd em cd reg ratio convers bruma treatment trigger higher proport total activ immun cell activ cd cd em cell lower ratio cd em cellscd reg cd em cellscd reg inflammatoryrepar monocyt notabl mycobacteri cell envelop composit bruma strong impact immun microenviron shape b myeloid cell compart cell matur profil thus improv surviv overal demonstr bladder immun microenviron induc mycobacteri treatment speci specif shape mycobacteri cell envelop composit therefor global bladder immun microenviron remodel improv qualiti infiltr immun cell balanc inflammatori regulatorysuppress respons increas surviv
|
D001749;D009161
|
T191;T007
|
36,304,455
|
immun relat serpina biomark involv diabet nephropathi renal tubular injuri diabet nephropathi dn lead caus end stage renal diseas becom serious medic issu global although known associ glomerular injuri tubular injuri found particip dn recent year howev mechan diabet renal tubular injuri remain unclear investig differenti express gene renal tubul patient dn analyz three rna seq dataset download gene express omnibus databas gene set enrich analysi weight gene co express network analysi show dn high correl immun system immun relat gene serpina screen lasso regress kaplan meier surviv analys consid serpina inhibitor mast cell chymas examin express level serpina chymas human renal tubular biopsi found serpina upregul dn tubul consist result differenti express analysi besid infiltr degranul rate mast cell augment dn summar biolog function serpina chymas mast cell dn base result previous studi specul serpina protect immun relat molecul prevent renal tubular injuri inhibit prolifer activ mast cell downregul activ chymas
|
D003928;D003920;D015843
|
T123;T047;T121;T116
|
36,304,454
|
ferroptosi musculoskelet diseas iron maiden cell death may promis therapeut target ferroptosi novel form cell death precis regul iron metabol antioxid process lipid metabol play irreplac role develop mani diseas musculoskelet disord msks includ osteoporosi osteoarthr rheumatoid arthriti intervertebr disc degener sarcopenia rhabdomyolysi becom one common caus disabl major burden public health social care system mechan ferroptosi msks recent elucid review briefli introduc ferroptosi mechan illustr patholog role ferroptosi msks focus ferroptosi exploit promis treatment strategi notabl toxic compound inhibit induc ferroptosi organ larg unknown ferroptosi appear doubl edg sword point research need futur verifi therapeut effect base ferroptosi msks
|
D000079403;D012206
|
T046;T043
|
36,304,453
|
dynam analysi immun status patient intracrani germ cell tumor establish immun risk prognost model immun status evalu mean lymphocyt subset count immun factor cancer studi analyz peripher blood immun index surviv outcom intracrani germ cell tumor igct patient
|
D009369;D009373
|
T191
|
36,304,452
|
lesson learn immunolog character nanomateri nanotechnolog character laboratori nanotechnolog carrier becom common pharmaceut product benefit drug deliveri includ reduc toxic improv efficaci activ pharmaceut ingredi due target deliveri prolong circul time control payload releas avail exampl reduc drug toxic formul use nanocarri encourag current data also demonstr nanoparticl may chang drug biodistribut alter toxic profil moreov individu compon nanoparticl excipi common use formul often immunolog inert contribut overal immun respons nanotechnolog formul product said immun respons may benefici advers depend indic dose dose regimen rout administr therefor comprehens toxicolog studi paramount import even previous known drug compon excipi use nanoformul recent data also suggest despit decad research direct hide nanocarri immun recognit immun system inher properti clear particul materi leverag improv therapeut efficaci drug formul use nanoparticl herein review current knowledg nanoparticl interact immun system interact contribut nanotechnolog formul drug product safeti efficaci len decad nanoparticl character nanotechnolog character laboratori
|
D005079;D049329
|
T120;T122;T073
|
36,304,451
|
chicken antibodi high suitabl particl enhanc turbidimetr assay antibodi base assay common use clinic laboratori analyz plasma serum sampl particular protein marker although assay tradit base antibodi rais mammal eg mice rabbit goat sever advantag use avian antibodi igi rais chicken includ product volum cost ethicalanim welfar consider disadvantag use mammalian igg assay potenti agglutin expos rheumatoid factor rf serum howev use free form immun complex form avian antibodi report less abil form mammalian antibodi caus light scatter use instrument measur addit amount antigen exceed maximum precipit point relat amount antibodi rapid declin absorb valu immun complex antigen excess igi use howev avian antibodi conjug substrat use particl enhanc turbidimetr assay petia problem avoid investig three clinic assay use chicken antibodi one use free unbound igi two igi base petia igi petia demonstr strong scatter respons even high antigen concentr contrast steep declin seen free igi antibodi igi petia reagent provid test result low coeffici variat duplic sampl also investig effect rf agglutin mammalian antibodi igg mous rabbit sheep human chicken antibodi wherea agglutin observ mammalian antibodi presenc rf observ chicken igi result support grow bodi evid chicken egg yolk thus valuabl sourc antibodi use petia clinic laboratori
|
D002645;D000936
|
T129;T116;T012
|
36,304,450
|
central gene transcript regulatori network shape monocyt develop bone marrow develop monocyt bone marrow complex process multipl step use rna seq data analyz transcriptom profil develop stage monocyt includ hematopoiet stem cell hscs common myeloid progenitor cmps granulocyt monocyt progenitor gmps monocyt found gene relat potassium cation transmembran activ ion bind upregul differenti hscs cmps protein transport membran surfac function molecul signific upregul gmp stage cdrac proteasom pathway signific upregul develop hscs monocyt transcript factor ank runx hmga klf nfia bmyc upregul differenti hscs cmps gfi hmgn high express differenti cmps gmps seventeen transcript factor includ foxo cdknd foxo ep pia nfkb creb bcl pppcb statb nfatc mefa stat ifnar irf irf cebpb identifi potenti involv develop gmps monocyt mice human metabol pathway regul hscs high glucos lipid nucleic acid metabol activ cmps main regul tca cycl relat gene gmps extrem activ metabol signific elev pentos phosphat pathway tca cycl histidin metabol purin metabol monocyt phase tricarboxyl acid tca cycl reduc anaerob glycolysi process becom domin overal studi offer kinet map gene transcript express cell metabol monocyt develop bone marrow
|
D001853;D009000
|
T023;T025;T024
|
36,304,449
|
sar cov specif antibodi trajectori mother infant two month follow matern infect infant expos caregiv infect sar cov may heighten infect risk relat older children due intens care feed need howev limit research covid outcom expos infant beyond neonat period june march conduct interview collect capillari dri blood spot sar cov infect mother infant age month two month follow matern infect onset covid group breastfeed compar data also collect breastfeed mother known sar cov infect exposur breastfeed control group mother test sar cov negat experienc symptom close contact exposur covid group breastfeed dri blood spot assay anti sar cov rbd igg iga posit anti sar cov igg concentr within covid group mean probabl seroposit among infant sampl lower correspond matern sampl respect igg respect iga likelihood infant infect posit associ number matern symptom household infect report covid mother report lower incid covid symptom among infant compar household adult infant similar pcr posit rate household children sampl return covid mother infant test antibodi posit among breastfeed control group mother none infant test antibodi posit least one sampl result support previous research demonstr minim risk infant follow matern covid infect includ breastfeed infant
|
D000086402;D000086382
|
T005;T067;T047
|
36,304,448
|
specif locat galactosyl afucosyl antivir monoclon antibodi affect fcriiia bind affin monoclon antibodi mab compris essenti type biolog therapeut use treat diseas anti cancer anti inflammatori properti abil protect respiratori infect product involv post translat glycosyl biosynthet process conjug glycan protein play crucial role mab bioactiv includ effector function pharmacokinet glycan heterogen divers chemic structur whose composit sensit manufactur condit render understand specif glycan structur affect mab bioactiv challeng need delin effect specif glycan mab bioactiv determin whether chang certain glycosyl profil occur manufactur signific affect product qualiti use enzymat transglycosyl chemic defin n glycan show galactosyl specif locat n glycan afucosyl anti viral mab respons fcriiia bind antibodi depend cell mediat cytotox adcc activ report facil method obtain purifi asymmetr mono galactosyl biantennari complex n glycan influenc bioactiv upon incorpor afucosyl mab use elisa surfac plasmon reson flow cytometri show galactosyl antenna antenna consist increas fcriiia bind affin confirm relev anti viral model respiratori syncyti virus rsv use adapt adcc report assay correl structur function relationship interact galactos residu antenna protein backbon use h n nmr show galactosyl locat exhibit chemic shift perturb compar glycoform lack galactos residu result highlight import identifi quantifi specif glycan isom ensur adequ qualiti control batch batch biosimilar comparison
|
D000911;D005690
|
T129;T123;T116;T109
|
36,304,447
|
impact host respons osteoblast lineag cell periodont diseas periodont involv loss connect tissu attach alveolar bone singl cell rna seq experi provid new insight resid cell infiltr immun cell function respons bacteri challeng periodont tissu periodont diseas induc combin innat adapt immun respons bacteri dysbiosi initi resid cell includ epitheli cell fibroblast recruit immun cell chemokin cytokin stimul recruit osteoclast precursor osteoclastogenesi respons tnf il il il rankl factor inflamm also suppress coupl bone format limit repair osteolyt lesion bone line cell osteocyt periodont ligament cell play key role process periodont ligament contain cell exhibit similar tendon cell osteoblast lineag cell mesenchym stem cell bone line cell consist mesenchym stem cell osteoprogenitor osteoblast influenc osteocyt stimul format osteoclast precursor mcsf rankl direct induc osteoclastogenesi follow bone resorpt factor releas resorb bone matrix osteoclast osteal macrophag recruit osteoblast precursor resorb bone surfac osteoblast differenti coupl bone format regul multipl signal pathway includ wnt notch fgf igf bmp hedgehog pathway diabet cigarett smoke age enhanc patholog process increas bone resorpt inhibit coupl bone format acceler bone loss bone patholog rheumatoid arthriti post menopaus osteoporosi bone unloadingdisus also affect osteoblast lineag cell particip format osteolyt lesion promot bone resorpt inhibit coupl bone format thus periodont involv activ inflammatori respons involv larg number cell stimul bone resorpt limit osseous repair process
|
D001862;D010518;D010510
|
T047;T042
|
36,304,446
|
develop valid four ferroptosi relat gene signatur correl immun implic hepatocellular carcinoma hepatocellular carcinoma hcc one common malign tumor tumor present insidi onset rapid progress frequent recurr ferroptosi newli discov mode program cell death may play key role progress hcc studi aim investig prognost valu ferroptosi relat gene frgs hcc impact tumor immun function therebi provid new insight target therapi hcc first differenti express frgs identifi use tcga databas four prognost relev methyl driven frgs gpd hell rrm stmn screen via surviv methyl analys gene co express mutat clinicopatholog character indic four pivot frgs play essenti role tumor progress also valid four gene use transcriptom proteom data well cohort sampl patient moreov receiv oper characterist roc curv confirm signatur four frgs independ prognost factor hcc gene set enrich analysi four frgs show statist signific associ pathway relat hcc prolifer final timer tisidb databas indic four frgs statist signific correl tumor infiltr immun cell immun checkpoint express taken togeth studi provid inform guid novel therapeut strategi target frgs hcc treatment
|
D006528;D008113;D000079403
|
T191;T043
|
36,304,255
|
interferon stimul interleukin deriv dendrit cell regul th differenti stat pathway initi progress allerg asthma aa associ complex interact inflamm immun respons herein report specif mechan under molecular action interferon ifn aa regul specul ifn inhibit th differenti regul secret interleukin il dendrit cell dcs therebi suppress airway inflamm asthma construct mous model ovalbumin induc aa overexpress ifn evalu effect il th axi via vitro effect ifn il secret dcs influenc th differenti asthmat inflamm ifn overexpress reduc proport th cell dcs alter lung morpholog cytokin product aa induc mice thus suppress aa phenotyp addit exogen ifn stimul promot secret il suppress th differenti cd cell via signal transduc activ transcript stat signal time depend manner studi aim clarifi regulatori effect mechan ifn dcsil th axi aa provid novel insight effect target treatment asthma
|
D064094;D001249
|
T129;T047;T116
|
36,304,254
|
comprehens analysi oncogen role target protein xklp tpx human malign mitosi spindl assembl requir microtubul associ protein xenopus kinesin like protein tpx although tpx high express sever malign tumor form littl known role cancer studi perform gene set enrich analysi tpx type cancer extens pan cancer bioinformat analysi use prognosi tumor mutat burden microsatellit instabl tumor microenviron immun cell infiltr data accord differenti express studi tpx found overexpress across studi cancer type base surviv analysi increas tpx express associ poor prognosi cancer tpx express level confirm correl clinic stage microsatellit instabl tumor mutat burden across cancer type furthermor tpx express link tumor microenviron immun cell infiltr particular bladder urotheli carcinoma liver hepatocellular carcinoma lung adenocarcinoma stomach adenocarcinoma uterin corpus endometri carcinoma final gene set enrich analysi implic tpx regul aminoacyl trna biosynthesi import tumor cell cycl signal pathway comprehens pan cancer analysi show tpx prognost molecular biomark cancer suggest potenti effect therapeut target treatment diseas
|
D002295;D001749;D006528;D008113
|
T191
|
36,304,253
|
drug qualiti supervis strategi differ distribut channel pharmaceut suppli chain aim dual channel pharmaceut suppli chain consist two distribut channel offlin medic institut onlin e commerc platform take account impact differ strateg choic made relev stakehold drug qualiti differ distribut channel articl construct evolutionari game model involv particip govern regul pharmaceut enterpris medic institut pharmaceut e commerc compani stabl equilibrium point particip strateg choic solv stabil strateg combin analyz lyapunov first method matlab b use simul verifi influenc decis variabl strateg choic differ particip result show first purpos punish ensur drug qualiti pharmaceut suppli chain fine high restrain econom behavior pharmaceut enterpris conduc perform social respons relev particip second probabl govern regul strict supervis pharmaceut suppli chain probabl pharmaceut enterpris provid high qualiti drug negat relat addit cost third whether medic institut pharmaceut e commerc compani choos inspect affect multipl factor inspect cost sale price sale cost furthermor penalti non inspect pharmaceut e commerc compani greater threshold f ensur choos inspect strategi final articl put forward countermeasur suggest drug qualiti supervis differ distribut channel pharmaceut suppli chain
|
D003132;D006076
|
T078;T092;T097;T081;T057
|
36,304,252
|
potenti product loss uncorrect correct presbyopia low middl incom countri life tabl model studi estim burden potenti product loss due uncorrect correct presbyopia lmic among work age popul cross section longitudin manner
|
D011305
|
T047
|
36,304,251
|
evalu mexican poverti reduct polici covid pandem impact mexican economi declin two consecut year especi last one hit declin covid pandem impact one worst oecd club also deepest econom recess sinc nation histori time number peopl poverti poverti rate increas compar regist analysi find current mexican govern increas intens scope implement social relief polici adher princip good first poor por el bien de todo primero los pobr howev context recess caus covid neither general decreas resid incom could avoid number peopl poverti reduc besid accord benefit obtain distinct household decil base incom expenditur survey publish inegi show implement govern relief measur relat reduc support low incom peopl aggrav deterior poverti due indiffer applic respect high incom household low incom one therefor defici respons implement face epidem especi poverti allevi action social relief polici enhanc poverti problem least partial sens recov improv econom growth rate soon possibl enough reduc poverti accompani necessari adjust poverti allevi measur social relief polici especi focal approach inclin low incom segment popul
|
D000086382
|
T047;T067
|
36,304,250
|
characterist grave diseas children adolesc nanj retrospect investig studi cross section studi analyz clinic characterist newli diagnos grave diseas gd children adolesc provid clinic evid earli diagnosi gd
|
D006111
|
T047
|
36,304,249
|
physic activ mental health sport univers student covid school confin shanghai shanghai serious affect coronavirus diseas covid pandem govern implement citywid static manag month well univers shanghai chang normal learn live style sport student led declin physic activ level physic activ strong correl mental health studi aim investig current state physic activ pa mental health student shanghai univers sport tri reveal correl pa depress symptom anxieti symptom fear covid smartphon addict
|
D000086382
|
T047;T067
|
36,304,248
|
covid vaccin accept hesit patient parkinson diseas coronavirus diseas covid vaccin campaign underway littl known vaccin coverag under barrier vaccin campaign patient parkinson diseas pd
|
D010300;D000086382;D007252
|
T129;T121;T067;T109;T047
|
36,304,247
|
associ high pm level short term medium term lung function recoveri patient pulmonari lobectomi associ exposur ambient fine particul matter aerodynam diamet pm short medium term lung function recoveri lfr patient undergo lobectomi remain uncertain studi investig associ pm concentr lfr adult patient n underw video assist thoracoscop vat lobectomi guangzhou china januari june patient underw least two spirometri test environment pm concentr period collect nearest monitor station multipl linear regress mlr model employ investig associ chang pm concentr lfr patient underw lobectomi adjust potenti confound assess short medium term lfr patient underw lobectomi three month averag pm concentr patient residenti area divid region mild pollut pm gm moder pollut gm pm gm sever pollut gm pm period mlr model confirm pm independ risk factor affect short term forc lung capac fvc forc expiratori volum fev maximum expiratori flow vital capac mef recoveri adjust p respect mlr model confirm pm independ risk factor affect medium term mef recoveri adjust p compar moder sever pollut period short medium term lfr fvc fev mef patient mild pollut period faster better p p p p p p respect thus exposur high pm level associ signific reduc speed degre short medium term lfr patient underw lobectomi
|
D000393
|
T131
|
36,304,246
|
person protect equip ppe relat advers skin reaction among healthcar worker main covid isol center barbado use person protect equip ppe reduc risk transmiss infecti agent signific among healthcar worker hcws studi aim investig preval characterist ppe relat advers skin reaction among hcws work main covid isol center barbado
|
D000067393;D000086382
|
T047;T073;T067
|
36,304,245
|
rural migrat govern public health nexus implic econom develop deepen rural age increas role human capit non agricultur employ labor market paper use data china health retir longitudin studi charl ordinari least squar ol instrument variabl method iv tri examin impact rural migrant worker educ parent health sinc rural famili may includ one child sampl migrant worker high educ level use benchmark regress sampl migrant worker low educ level use test robust relationship result show educ migrant worker signific posit impact parent health sampl least educ use robust result chang iv probit method use address potenti endogen result remain stabl heterogen analysi show signific differ impact migrant worker educ health parent differ group posit effect greater impact health parent older less educ live children mediat analysi show children econom abil captur incom work type parent health behavior captur sleep alcohol consumpt physic examin mediat relationship thus migrant worker educ affect parent health main relax budget constraint improv parent health product effici addit paper also found educ migrant worker may signific increas parent depress base analysi paper argu increas invest rural educ conduc improv health migrant farmer parent therebi promot transfer rural labor non agricultur industri citi curb rapid rise labor cost promot healthi develop economi
|
D057217;D014171
|
T081;T098
|
36,304,244
|
train need curriculum continu medic educ among general practition tibet china cross section survey uneven distribut health resourc higher tibet region develop core profession capabl general practition gps main goal continu medic educ cme train program
|
D058005
|
T097
|
36,304,243
|
systemat review scientif evid pulmonari carcinogen talc conduct systemat review assess potenti pulmonari carcinogen inhal talc human systemat review method adher prefer report item systemat review meta analys prisma guidelin incorpor aspect us institut medicin iom sever unit state us environment protect agenc epa framework systemat review comprehens literatur search conduct detail data abstract studi qualiti evalu adapt us toxic substanc control act tsca framework central analysi literatur search select process identifi primari studi assess exposur talc pulmonari cancer risk human n anim n integr stream evid accord iom framework yield classif suggest evid associ inhal talc lung cancer pleural mesothelioma human relev exposur level
|
D013627
|
T121;T197
|
36,304,242
|
spatial differ thermal comfort summer coastal area studi dalian china thermal comfort import indic evalu environ urban public space appropri thermal comfort effect prolong durat outdoor activ exist studi lack thermal comfort comparison hot spot cold spot studi select coastal citi dalian china studi area conduct field investig thermal comfort two landmark resort name downtown commerci street coastal leisur park studi conduct typic summer day consist interview sever resid understand thermal comfort requir investig thermal expect interviewe meteorolog measur questionnair univers thermal climat index utci use determin thermal benchmark site subject result indic globe temperatur air temperatur import factor affect thermal comfort follow relat humid wind speed summer daytim shade space comfort open space tree shade prefer artifici shade coastal park neutral utci nutci respond c coastal park c commerci street neutral utci rang nutcir c coastal park c commerci street upper thermal accept rang limit coastal park commerci street c respect substanti higher upper nutcir limit indic resid dalian well adapt hot weather result provid good refer determin ideal design strategi optim thermal environ urban outdoor recreat space summer improv qualiti life coastal citi
|
D013697;D011788
|
T078;T040
|
36,304,241
|
region burden chronic kidney diseas north africa middl east result global burden diseas studi updat burden data chronic kidney diseas ckd one preval non communic diseas essenti proper provis healthcar policymak aim estim burden ckd attribut burden north africa middl east region name
|
D003924;D051436;D006973
|
T047
|
36,304,240
|
prevent measur covid pandem mexico cross section studi understand mexican behav pandem could present complet pictur phenomenon countri provid better manag
|
D000086382
|
T047;T067
|
36,304,239
|
associ lifestyl covid vaccin nation cross section studi assess lifestyl covid vaccin coverag rate relationship lifestyl covid vaccin among chines popul
|
D000086663;D000086382
|
T200;T047;T067
|
36,304,238
|
key determin school breakfast program implement philadelphia public school implic role snap ed polici address food insecur effect implement success serv risk univers school meal provid key intervent school serv predomin low incom famili provid free school breakfast lunch unfortun low uptak provis among student concern especi regard school breakfast warrant key implement support school ensur student nutrit need met thus purpos studi evalu determin implement two differ school breakfast program pragmat strategi serv breakfast way maxim student particip
|
D062408;D005522
|
T056;T095;T057
|
36,304,237
|
preval sepsi among adult china systemat review meta analysi sepsi major public health problem ignor china even world howev preval sepsi chines adult vari among differ studi
|
D018805;D012772
|
T047;T046
|
36,304,236
|
preval syphili chlamydia trachomati infect among men sex men jiangsu provinc china cross section survey epidem sexual transmit infect stis among men sex men msm major global public health concern studi aim examin preval syphili chlamydia trachomati ct infect associ factor among msm jiangsu provinc china hope provid updat data formul relev polici
|
D013587;D015658;D000072339;D002690;D012749;D006526
|
T047;T098
|
36,304,235
|
doubl chain system onlin offlin medic data share via privat consortium blockchain system design studi informat develop digit construct healthcar industri electron medic record internet medicin facilit peopl medic treatment howev current data storag method risk data loss leakag tamper ca nt support extens secur share medic data realiz effect secur medic data storag share among offlin medic institut internet medicin platform studi use combin privat blockchain consortium blockchain design medic blockchain doubl chain system mbds system store encrypt medic data distribut storag mode systemat integr medic data patient offlin medic institut internet medicin platform achiev equal credibl data share among particip node mbds system construct studi incorpor internet medicin care servic current healthcar system provid new solut practic guidanc futur develop collabor medic care studi help solv problem medic data interconnect resourc share improv effici effect diseas diagnosi allevi contradict doctor patient facilit person health manag studi substanti theoret practic implic research applic medic data storag share
|
D000081186
|
T066
|
36,304,208
|
self direct neurofeedback treatment subject tinnitus patient evalu multimod function imag neurofeedback nfb relat novel approach treatment tinnitus prior studi demonstr increas alpha activ rather reduc delta power seem drive nfb relat improv tinnitus symptom present studi therefor design explor whether implement alpha train protocol portabl neurofeedback apparatus would achiev improv tinnitus patient symptom studi tinnitus patient underw nfb train enrol control group studi singl blind particip awar group assign nfb group underw nfb train session week addit pre posttrain test includ tinnitus handicap inventori thi tinnitus handicap questionnair thq visual analog scale vas electroencephalographi eeg function magnet reson imag fmri result find thi thq vas score patient two group assess week train period score unchang control patient wherea signific improv nfb group patient eeg analys reveal alpha band increas occipit lobe follow nfb treatment fmri indic increas region homogen reho right frontal lobe patient nfb group treatment negat correl thi vas score result analysi indic alpha nfb train effect use reduc tinnitus relat distress sound percept patient
|
D058765;D014012
|
T061;T184;T037;T047;T041
|
36,304,176
|
establish clinic construct intrins capac older adult predict function declin world health organ conceptualis health healthcar older adult around concept healthi age healthi age defin process develop maintain function abil enabl well older age function abil sum two key factor intrins capac interact environ concept intrins capac encompass wide spectrum health characterist includ physiolog psycholog chang associ age process general ic declin high stabl state impair status peopl age monitor individu chang intrins capac context environ provid holist method track function older adult popul individu level provid opportun address revers factor declin howev would requir clear object conceptualis concept intrins capac
|
D000203;D000073656;D060825
|
T056;T048;T102;T080
|
36,304,175
|
effect preoper oral salin administr postop delirium older person random control trial postop delirium pod serious affect recoveri older person increas mortal rate surgeri aim evalu preoper oral salin administr postop delirium older person undergo spinal decompress
|
D000077330;D003693
|
T121;T197;T048
|
36,304,174
|
understand role qualiti life strategi use older carer older peopl maintain health well nation australian survey carer play critic role support older peopl health problem remain live home studi aim understand role qualiti life older carer older peopl identifi strategi use manag health well
|
D017028;D011788
|
T078;T099;T098;T097
|
36,304,138
|
associ twenti four hour ambulatori blood pressur variabl cerebr small vessel diseas burden acut ischem stroke studi aim investig associ twenti four hour ambulatori blood pressur variabl monitor abpm cerebr small vessel diseas csvd burden acut ischem stroke ai patient
|
D000083242;D059345
|
T047
|
36,304,092
|
long term surviv benefit sustain releas fluorouracil implant patient stage ii iii gastric cancer prognosi gastric cancer advanc stage remain poor exact efficaci use intraop sustain releas chemotherapi fluorouracil fu advanc stage gastric cancer still unelucid
|
D013274
|
T191
|
36,304,091
|
clearanc liver remnant predict short term outcom patient undergo resect hepatocellular carcinoma estim function reserv remnant liver import reduc morbid mortal
|
D006528;D008113;D017093
|
T047;T191
|
36,304,090
|
red blood cell distribut width deriv alcohol relat liver cirrhosi metabol associ fatti liver diseas look undiscov blood marker liver fibrosi steatosi still remain issu worth explor still plenti unresolv issu relat actual role hematolog indic potenti marker liver function
|
D065626
|
T047
|
36,304,089
|
comparison evalu index gastroenterolog hepatolog journal differ databas accur assess qualiti academ journal great signific journal impact factor jif calcul clariv base upon web scienc literatur databas citescor cs develop elseiv base upon scopus databas enjoy high uptak worldwid effort continu toward creation scientometr index provid ever greater qualit insight journal impact effort yield newli launch journal articl influenc index jaii base refer citat analysi rca databas open multidisciplinari citat analysi databas base artifici intellig technolog
|
D005762;D010506
|
T170;T091;T073
|
36,304,088
|
new score system evalu adjuv chemotherapi patient tnm gastric cancer gastrectomi present insuffici medic evid determin whether adjuv chemotherapi necessari tnm gastric cancer
|
D013274
|
T191
|
36,304,087
|
gastrointestin liver diseas patient schizophrenia narrat review schizophrenia sever mental ill devast impact individu qualiti life comorbid high amongst patient life expect approxim year less general popul despit well known increas mortal littl known impact gastrointestin liver diseas patient schizophrenia aim review literatur make recommend regard futur care literatur search perform pubm identifi studi relat gastrointestin liver diseas patient schizophrenia high rate chronic liver diseas report non alcohol fatti liver diseas particular concern antipsychot metabol syndrom contribut factor rate acut liver failur low associ antipsychot use paracetamol overdos coeliac diseas histor link schizophrenia howev recent research suggest causal link yet proven evid emerg regard relationship schizophrenia peptic ulcer diseas inflammatori bowel diseas irrit bowel syndrom clinic vigil regard condit high patient schizophrenia poor engag bowel cancer screen programm lead late diagnosi increas mortal clozapin induc constip signific issu mani patient requir close monitor signific burden gastrointestin liver diseas amongst patient schizophrenia better level support member medic team essenti ensur appropri time care provid
|
D012559;D014150;D008107
|
T039;T121;T033;T047;T048
|
36,304,086
|
ultrasound base artifici intellig gastroenterolog hepatolog artifici intellig ai especi deep learn gain extens attent excel perform medic imag analysi automat make quantit assess complex medic imag help doctor make accur diagnos recent year ai base ultrasound shown help diffus liver diseas focal liver lesion analyz sever nonalcohol fatti liver stage liver fibrosi identifi benign malign liver lesion predict microvascular invas hepatocellular carcinoma curat transarteri chemoembol effect prognos thermal ablat moreov ai base endoscop ultrasonographi appli gastrointestin diseas distinguish gastric mesenchym tumor detect pancreat cancer intraduct papillari mucin neoplasm predict preoper tumor deposit rectal cancer review focus basic technic knowledg ai clinic applic ai ultrasound liver gastroenterolog diseas last discuss challeng futur perspect ai
|
D005762;D006528;D016461;D008113
|
T061;T191;T091
|
36,304,085
|
oxid stress bridg gut microbiota occurr frailti syndrom incid frailti gradual increas age condit place heavi burden modern societi age popul increas frailti one complic clinic syndrom thus difficult uncov under mechan oxid stress os involv frailti multipl way associ gut microbiota gm frailti recent report herein propos os involv associ gm occurr frailti syndrom imbal oxid antioxid eventu lead frailti gm probabl particip process product reactiv oxygen speci hand os disturb gm dysbiosi consequ induc exacerb tissu damag lead occurr frailti syndrom final discuss possibl improv frailti interven vicious cycl imbal os dysbiosi
|
D000073496;D000069196
|
T184;T007;T033;T046;T001
|
36,304,084
|
time endoscop retrograd cholangiopancreatographi treatment acut cholang differ sever optim time endoscop retrograd cholangiopancreatographi ercp acut cholang ac uncertain especi patient ac vari sever
|
D002761;D042883
|
T047
|
36,304,083
|
effect low dose radiat thyroid function gut microbiota thyroid gut axi great influenc mainten human health howev know littl effect low dose ioniz radiat ldr thyroid hormon level gut microbiota composit
|
D000069196
|
T007;T001
|
36,304,082
|
hypoxia induc factor promot interleukin receptor antagonist express hepat ischemia reperfus injuri ischemia reperfus injuri iri major risk associ liver surgeri transplant patholog mechan complex interleukin receptor antagonist il ra protect liver iri howev regulatori mechan il ra express still unclear
|
D051795;D053590;D015427
|
T123;T121;T116;T109;T037
|
36,304,080
|
analysi influenc innov teach manag mode univers student one one train psychotherapi studi expect investig verifi intervent effect univers innov teach manag model colleg student resili implement univers innov teach manag model colleg student low psycholog resili
|
D009788
|
T061
|
36,304,079
|
waterloo handed questionnair cross cultur adapt psychometr properti arab version handed one studi behaviour predictor cerebr later assess handed often essenti neuropsycholog motor behaviour research thus import self report assess tool determin handed avail multipl languag differ cultur purpos present studi conduct translat cross cultur adapt waterloo handed questionnair arab languag assess psychometr properti two independ forward translat perform two nativ arab speaker synthes one version synthes version backtransl english two independ bilingu translat expert committe form review translat adapt process final arab version whq obtain whq ar two hundr nineti adult arab speaker recruit particip studi investig properti whq ar result show whq ar floor ceil effect construct valid result factor analysi reveal whq ar two dimens whq ar excel intern consist cronbach alpha test retest reliabl intraclass correl coeffici score bland altman plot show accept agreement test retest score therefor whq ar valid reliabl tool readi use among arab speak popul determin handed
|
D007802;D009788
|
T061;T171
|
36,304,068
|
identifi hub gene immun cell infiltr progress carotid atherosclerot plaqu context predict prevent use integr bioinformat approach machin learn strategi emerg evid show carotid atherosclerosi relat activ immun relat pathway inflammatori cell infiltr howev immun link pathway help advanc carotid atherosclerot plaqu associ plaqu infiltr status bodi immun cell still unclear express profil gene express progress carotid atherosclerot plaqu retriev gene express omnibus databas differenti express gene examin weight gene coexpress network analysi techniqu identifi one brown modul show greatest correl carotid atherosclerot plaqu total intersect gene could detect combin deg lasso regress analysi subsequ perform obtain five hub gene potenti biomark carotid atherosclerot plaqu function analysi emphas vital role play inflamm immun system relat pathway diseas immun cell infiltr result highlight signific correl among cd cell b cell macrophag cd cell thereaft gene express level diagnost valu relat everi hub gene valid result indic macrophag b cell cd cell cd cell close relat format advanc stage carotid atherosclerot plaqu base result could hypothes express hub gene car slamf tmema fermt gimap assist advanc earli stage advanc stage carotid atherosclerot plaqu immun relat signal pathway may help provid novel strategi treatment carotid plaqu context predict prevent person medicin
|
D058226
|
T046;T020;T031
|
36,303,949
|
initi survey preval group b streptococcus gbs among yemeni pregnant women sana citi infect group b streptococcus gbs still neonat life threaten ill especi develop countri yemen
|
D013290;D011251
|
T047
|
36,303,948
|
fyu net cascad segment network kidney tumor medic imag autom segment renal tumor essenti diagnost evalu kidney cancer howev renal tumor volum general small compar volum kidney irregular distribut moreov locat shape renal tumor high variabl make segment task extrem challeng solv aforement problem cascad segment model fyu net comput tomographi ct imag propos paper achiev automat kidney tumor segment propos model involv two main step first step fast scan kidney ct data perform use local network find slice contain tumor coars segment perform simultan second step segment framework embed featur pyramid network modul employ fine segment kidney tumor build featur pyramid structur target differ size distribut detect differ featur layer extract richer featur inform addit top structur allow inform higher level featur map transfer lower level featur map enhanc semant inform lower level featur map compar experi conduct kidney pars challeng public dataset averag jaccard coeffici averag dice coeffici tumor structur segment respect result demonstr effect propos model kidney tumor segment
|
D014057;D007680
|
T060;T191
|
36,303,877
|
risk sever covid infect person diabet first second wave denmark nationwid cohort studi coronavirus diseas covid increas risk hospit death diabet diabet relat condit examin tempor trend covid relat hospit mortal total danish popul diabet diabet relat condit two first wave covid denmark
|
D000086382;D003920
|
T047;T067
|
36,303,876
|
diagnosi treatment liver metastas parathyroid carcinoma parathyroid carcinoma pc rare endocrin malign occur less case primari hyperparathyroid phpt liver second common target organ distant metastas pc guidelin avail diagnosi treatment liver metastas studi attempt summar characterist diagnosi treatment liver metastas base patient case report literatur
|
D008113;D010282
|
T191
|
36,303,875
|
bodi mass index basal insulin glycem control children type diabet treat advanc hybrid close loop system remain stabl year prospect observ two center studi inform influenc insulin treatment use advanc hybrid close loop system ahcl bodi weight young patient type diabet td scarc aim studi observ whether chang bodi mass index bmi children adolesc td treat use medtron minim g ahcl year follow analyz potenti associ chang insulin dose
|
D003922
|
T047
|
36,303,874
|
obes adolesc may associ limit daili activ increas level anxieti patient parent preliminari result pilot studi obes chronic diseas adolesc may lead serious consequ affect somat mental health studi aim assess preval depress symptom anxieti adolesc obes parent relationship depress anxieti symptom somat consequ obes also analyz
|
D063766
|
T033;T047
|
36,303,873
|
novel pituitari action gnrh teleost link reproduct feed regul gonadotropin releas hormon gnrh vital hypothalam neuropeptid key regul pituitari lutein hormon lh follicl stimul hormon fsh vertebr howev littl known pituitari action gnrh teleost present studi two gnrh variant name gnrh gnrh four gnrh receptor name gnrhr gnrhr gnrhr gnrhr isol grass carp tissu distribut display gnrhr high detect pituitari three gnrhrs interest ligand receptor select show gnrhr display similar high bind affin grass carp gnrh gnrh use primari cultur grass carp pituitari cell model found gnrh gnrh could signific induc pituitari reproduct hormon gene gth lh fsh inhba secretogranin mrna express mediat acpka plcip pkc ca camcamk ii pathway also reduc dopamin receptor drd mrna express via ca camcamk ii pathway interest gnrh gnrh could also stimul anorexigen peptid pomcb cart ut nmba nmbb mrna express via acpka plcip pkc ca camcamk ii pathway grass carp pituitari cell addit food intak could signific induc brain gnrh mrna express result indic gnrh coupl factor integr feed metabol reproduct teleost
|
D007987;D002347
|
T125;T121;T116;T013
|
36,303,872
|
integr analysi reveal novel associ dna methyl serum metabolom adolesc type diabet cross section studi rate type diabet td among adolesc rise epigenet chang could associ metabol alter adolesc td
|
D003924
|
T047
|
36,303,871
|
advanc glycat end product associ diabet neuropathi young adult type diabet advanc glycat end product age may contribut develop diabet neuropathi young adult type diabet aim investig associ age cardiovascular autonom neuropathi distal symmetr polyneuropathi dspn
|
D003929;D003922;D003924
|
T047
|
36,303,870
|
ovariectomi induc hormon depriv aggrav deposit basolater amygdala cholinerg fiber loss cortex cognit behavior symptom tripl transgen mous model alzheim diseas alzheim diseas common type dementia high preval elder women advanc progress may due decreas hormon synthesi post menopaus estradiol progesteron neuroprotect potenti aim confirm femal hormon deplet aggrav progress dementia tripl transgen mous model alzheim diseas xtg ad patholog hallmark known appear month old anim expect see diseas like chang month old xtg ad mice hormon deplet three month old femal xtg ad mice compar age match control menopaus model ovari remov ovx sham surgeri month recoveri bodi composit anim measur mri scan cognit anxieti paramet evalu differ behavior test model differ aspect maze morri water maze open field social discrimin elev plus maze light dark box fox odor oper condit condit fear test end experi uterus collect amyloid accumul cholinerg system brain examin immunohistochemistri uterus weight decreas bodi weight increas signific ovx anim mri data show bodi weight chang due fat accumul moreov ovx increas anxieti control decreas xtg ad anim later genotyp anxious default base anxieti z score general xtg ad mice move less relat cognit neither xtg ad genotyp ovx surgeri impair learn memori general despit progress dementia like behavior ovx histolog level ovx aggrav amyloid plaqu deposit basolater amygdala induc earli cholinerg neuron fiber loss somatosensori cortex transgen anim confirm ovx induc menopaus symptom remov sexual steroid aggrav appear ad relat alter brain without signific affect behavior thus ovx young month old xtg ad mice might suitabl model test effect new treatment option structur chang howev reveal benefici effect behavior later time point might need
|
D000544;D066272
|
T047;T023;T048
|
36,303,869
|
relationship thyroid disord vitamin narrat minireview term vitamin retinoid encompass group fat solubl compound essenti human nutrit retinol retin cis retino acid tretinoin cis retino acid fulli natur other synthet compound use most therapeut purpos evid indic nutrit status retinoid ie presenc absenc defici abl modul thyroid gland metabol vitamin defici tight correl structur function impair thyroid gland often associ iodin defici furthermor retinoid involv differ immun function well process activ prolifer differenti regulatori cell treg particular signific given high preval thyroid autoimmun disord whose pathogenesi seem relat alter homeostasi regulatori cell retinoid also involv modul gene express via interact nuclear receptor also act cofactor cell growth differenti abil retino acid increas iodin uptak sodium iodin symport activ human thyroid cancer cell line suggest retinoid deriv may use treatment differ thyroid tumor minireview summar current knowledg link nutrit intak vitamin various thyroid disord
|
D014801;D007455
|
T121;T123;T127;T109;T196
|
36,303,868
|
white common bean extract remodel gut microbiota amelior type diabet complic random doubl blind placebo control trial excess carbohydr intak high risk factor increas morbid type diabet td novel regimen dietari care diabet consist high activ amylas inhibitor deriv white common bean extract wcbe suffici carbohydr intak appli attenu td complic furthermor role gut microbiota remiss also investig
|
D000069196;D003924;D027805;D003929
|
T007;T001;T168;T047;T002
|
36,303,867
|
develop valid nomogram predict b cell primari thyroid malign lymphoma specif surviv popul base analysi b cell primari thyroid malign lymphoma bc ptml account case ptml howev develop effect treatment manag strategi bc ptml challeng owe rariti diseas studi assess data patient surveil epidemiolog end result seer databas diagnos bc ptml patient random divid train group n test group n ratio use hold method kaplan meier analysi log rank test use calcul surviv rate patient subsequ stepwis cox regress model establish screen prognost factor patient bc ptml variabl use construct nomogram predict year bc ptml cancer specif surviv css discrimin calibr new model evalu use concord index c index calibr curv accuraci benefit model assess comparison tradit ann arbor stage system use decis curv analysi dca stepwis regress optim model includ radiotherapi primari site surgeri ann arbor stage chemotherapi histolog subtyp age diagnosi c index area receiv oper characterist curv dca suggest nomogram improv discriminatori abil clinic benefit compar ann arbor stage system summari studi establish effect nomogram predict css patient bc ptml assist clinician develop effect individu treatment strategi
|
D049451;D008223
|
T081;T170;T191
|
36,303,866
|
clinic manifest associ factor acquir hypoaldosteron endocrinolog practic hypoaldosteron congenit acquir isol part primari adren insuffici caus aldosteron deficit resist combin reduc mineralocorticoid action induc decreas urin k h excret increas urin na excret lead hyperkalemia andor hyponatremia often combin metabol acidosi aim character clinic manifest hypoaldosteron associ factor
|
D006994;D006947;D007010;D000224;D000138
|
T033;T047;T046
|
36,303,865
|
associ covid infect sex steroid hormon coronavirus diseas covid caus infect sever acut respiratori syndrom coronavirus sar cov within month first outbreak declar global pandem lethal virus sar cov transmit respiratori droplet enter host cell angiotensin convert enzym ace receptor ace receptor high express mani tissu includ test therefor object studi summar avail literatur regard correl sex hormon level covid
|
D000086382
|
T047;T067
|
36,303,864
|
systemat review role melatonin mechan diabet relat reproduct impair non clinic studi diabet induc reproduct complic lead subfertil infertil rais need protect reproduct organ limit medic use improv reproduct health diabet patient melatonin main produc pineal gland may improv diabet associ reproduct complic various mechan may prefer candid protect reproduct system present review aim elucid under mechan melatonin effect reproduct system advers affect diabet mellitus dm
|
D008550;D003920
|
T125;T121;T047;T109
|
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