Javtor/biomedical-topic-categorization-validation

PMID int64 35.7M 36.4M	Title/Abstract stringlengths 22 8.78k	MeshTerms stringlengths 7 101	SemanticTypes stringlengths 4 64
36,303,279	quantit spatial map tissu water lipid content use spatial frequenc domain imag nm wavelength region significancewat lipid key particip mani biolog process label free non contact optic method spatial map compon vivo shortwav infrar meso pattern imag swir mpi emerg techniqu success address need howev requir dedic swir camera probe nm wavelength region hinder practic translat technologyaimcompar swir mpi aim develop new techniqu dramat reduc cost detector maintain high accuraci quantif tissu water lipid contentapproachbi util water lipid absorpt featur nm wavelength region well optim wavelength spatial frequenc combin develop new imag techniqu base spatial frequenc domain imag quantit map tissu water lipid content use regular silicon base cameraresultsth propos method valid phantom studi show averag error water content estim lipid content estim respect propos method also demonstr ex vivo porcin tissu lipid map well vivo longitudin water content monitoringconclusionsth propos techniqu enabl spatial map tissu water lipid content cost detector reduc two order magnitud compar swir mpi maintain high accuraci experiment result highlight potenti techniqu substanti impact scientif industri applic	D014867;D003952	T060;T121;T197
36,303,257	relationship lipoprotein risk cardiovascular diseas mendelian random analysi lipoprotein lp one residu risk factor cardiovascular diseas cvd set optim low densiti lipoprotein cholesterol ldl c associ lp cvd still exploratori phase studi indic causal connect lp various cvd	D002318;D020521	T047
36,303,256	role time perspect self control well ill covid pandem multipl mediat model grow bodi evid indic outbreak covid signific influenc individu cognit emot psycholog health studi aim explor effect associ time perspect self control well ill among colleg student china covid pandem	D000086382;D000068356	T055;T047;T067
36,303,255	season distribut cryptosporidium spp giardia duodenali enterocytozoon bieneusi tibetan sheep qinghai china cryptosporidium spp giardia duodenali enterocytozoon bieneusi caus import intestin diseas rumin howev data distribut three protozoan pathogen tibetan sheep limit	D021862;D016829;D003458;D003457;D005873;D016881	T047;T004;T204
36,303,253	associ hkme breast cancer prognosi estrogen receptor status cellular experi reveal decreas histon h lysin trimethyl hkme level associ upregul oncogen breast cancer cell moreov role hkme breast cancer close associ estrogen receptor er status therefor aim examin prognost valu hkme breast cancer er status level hkme tumor evalu tissu microarray immunohistochemistri women diagnos primari invas breast cancer hazard ratio hrs confid interv cis overal surviv os progress free surviv pfs estim use cox regress model interact hkme er prognosi assess multipl scale	D001943	T191
36,303,252	remark low host specif bat fli penicillidia fulvida diptera nycteribiida assess mitochondri coi nuclear sequenc data recognit delin morpholog indistinguish cryptic speci broad implic wildlif conserv diseas ecolog accur estim biodivers parasit intrigu studi cryptic speciat uniqu evolutionari pressur diversifi factor generat ecolog characterist host parasit relationship includ host specif bat fli diptera nycteribiida streblida oblig hematophag ectoparasit bat general exhibit high host specif one rare except penicillidia fulvida diptera nycteribiida african bat fli found associ mani phylogenet distant host one explan p fulvida extrem polyxeni may repres complex host specif yet cryptic speci increas common find molecular genet studi suppos generalist parasit	D004175;D002685	T015;T204
36,303,251	expert group consensus earli diagnosi manag infantil onset pomp diseas gulf region infantil onset pomp diseas iopd rare devast autosom recess lysosom storag disord manifest immedi birth sever iopd case completealmost complet acid alpha glucosidas enzym defici observ consid rapid progress diseas time diagnosi treatment import even slight delay remark alter cours diseas enzym replac therapi ert recombin human acid alpha glucosidas safe benefici iopd patient howev heterogen patient respons ert factor influenc treatment effect includ patient age time treatment initi pre exist muscl damag cross reactiv immunolog materi crim status baselin immunomodul along ert recent develop therapeut approach includ therapeut armamentarium iopd optim clinic benefit particular crim negat iopd patient howev dearth publish data earli diagnosi clinic posit immunomodul protocol along ert treatment iopd gulf region	D006009	T047
36,303,246	under molecular mechan biomark plaqu vulner base bioinformat analysi studi aim identifi under differenti express gene deg mechan unstabl atherosclerot plaqu use bioinformat method	D058226;D050197	T047;T046;T020;T031
36,303,243	protocol develop core outcom set laparoscop hiatal hernia repair hiatal hernia negat damag patient health life qualiti laparoscop hiatal hernia repair current gold standard treatment hiatal hernia lhhr numer clinic trial laparoscop hiatal hernia repair done publish find high variabl due lack uniqu outcom set basic outcom set ever establish previous decad procedur hiatal hernia repair yet protocol outlin procedur develop core outcom set laparoscop hiatal hernia repair cos lhhr cos lhhr provid uniqu criteria clinic investig	D010535;D006551	T060;T047;T061
36,303,242	heat labil enterotoxin enhanc f produc enterotoxigen e coli adhes porcin intestin epitheli cell upregul bacteri adhesin stb enterotoxin one crucial enterotoxin secret enterotoxigen escherichia coli etec heat labil enterotoxin lt enhanc bacteri adher vivo vitro howev under mechan remain unclear address evalu adher lt produc lt defici etec strain use ipec j cell model express level inflammatori cytokin chemokin tight junction protein evalu ipec j cell infect various etec strain level adhesin enterotoxin also evalu fac produc etec f etec strain treatment cyclic amp camp adher eltab mutant decreas compar wild type strain wherea adher pbr eltab strain mark increas compar parent strain product lt regul express tnf il cxcl il gene howev appear affect tight junction protein express import found camp lead upregul adhesin product stb enterotoxin moreov f etec strain treat camp also greater adhes ipec j cell adher faeg flic estb mutant decreas result indic lt enhanc adher f etec due primarili upregul f fimbria flagellin stb enterotoxin express provid insight pathogen mechan lt etec	D003967;D054307;D004768;D004927;D029968;D013553	T184;T123;T007;T116;T131;T047
36,303,240	bobbl head doll syndrom infant arachnoid cyst case report bobbl head doll syndrom rare uniqu movement disord common affect children younger year age character continu episod movement frequenc hz exact mechan bobbl head doll syndrom elucid endoscop ventriculocisternostomi optim treatment option literatur review less case bobbl head doll syndrom suprasellar arachnoid cyst	D016080;D020820;D006849;D020542	T184;T030;T033;T019;T047
36,303,237	readi yet limit state art diseas name entiti recogn intens research done area biomed natur languag process sinc breakthrough transfer learn base method bert model use varieti biomed clinic applic avail data set model show excel result part exceed inter annot agreement howev biomed name entiti recognit appli covid preprint show perform drop compar result test data question aris well train model abl predict complet new data ie general	D057225;D000086382	T047;T067;T066
36,303,236	difficulti facial emot recognit take psychopath alexithym trait account alexithym psychopath trait close associ distinct construct associ facial emot process deficit reflect empathi deficit howev under mechan contribut deficit well understood	D000066499	T041
36,303,235	oral anticoagul systemat overview review efficaci safeti genotyp self monitor stakehold experi systemat overview commiss england depart health social care dhsc assess evid direct previous novel oral anticoagul oac compar usual care adult prevent stroke relat atrial fibril af prevent treat venous thromboembol vte specif assess efficaci safeti genotyp self monitor patient clinician experi oac	D001281;D020521;D054556	T047;T046
36,303,234	alter bacteriom mycobiom metabolom characterist pcos patient normaloverweight individu character gut bacteriom mycobiom serum metabolom profil polycyst ovari syndrom pcos patient normaloverweight individu evalu potenti microbiota relat diagnost method develop pcos rrna gene sequenc use fecal sampl metabolom analysi serum sampl conduct pcos classifi base multiom marker construct signific bacteri fungal communiti metabolit differ among pcos patient healthi volunt normaloverweight individu healthi individu overweightobes display less abnorm metabol pcos patient uniqu higher abund fungal genus mortierella nine bacteri genera predict pathway fungal genera top metabolit screen distinguish pcos healthi control auc respect metabolit deriv model accur microb base model discrimin normal bmi pcos pcos lb normal bmi healthi healthi lb pcos hb healthi hb featur bacteria fungi predict pathway serum metabolit display higher associ free androgen index fai cooccurr network conclus data reveal hyperandrogenemia play central role dysbiosi intestin microecolog chang metabol status patient pcos effect exceed role bmi healthi women high bmi show uniqu microbiota metabol featuresth prioriti predict model discrimin pcos healthi status studi serum metabolit fungal taxa bacteri taxa	D011085;D000072761	T047;T004
36,303,231	insulin like peptid insl posit correl anti mllerian hormon amh women polycyst ovari syndrom case control studi insulin like peptid insl involv reproduct metabol process polycyst ovari syndrom pcos studi aim evalu relationship insl anti mllerian hormon amh	D054304;D011085	T125;T121;T047;T116
36,303,230	serum mmp sp vegf level reflect sever connect tissu diseas associ interstiti lung diseas interstiti lung diseas ild common pulmonari complic connect tissu diseas ctd studi aim evalu clinic diagnost valu matrix metalloproteinas mmp surfact protein sp vascular endotheli growth factor vegf potenti biomark ctd ild	D017563;D003240	T047
36,303,229	tim downregul toxoplasma gondii infect contribut decidu dendrit cell dysfunct women earli pregnanc infect toxoplasma gondii may sever advers pregnanc outcom spontan abort fetal malform inhibitori molecul cell immunoglobulin mucin domain tim high express decidu dendrit cell ddcs play import role maintain immun toler howev whether gondii infect caus ddc dysfunct influenc express tim particip advers pregnanc outcom still unclear	D003713;D000072597;D014123	T047;T116;T025;T192
36,303,228	pembrolizumab combin low dose cyclophosphamid intra tumor inject toll like receptor agonist g patient advanc pretreat soft tissu sarcoma result pembrosarc basket studi soft tissu sarcoma sts heterogen mesenchym tumor limit therapeut option advanc set immun checkpoint inhibitor shown signific clinic activ inflam sts character presenc tertiari lymphoid structur tls new strategi need sensit tls negat sts immunotherapi engag toll like receptor tlr signal pathway contribut develop favor tumor microenviron solid tumor g high potent toll like receptor tlr agonist hypothes intra tumor g would induc robust local potenti system anti tumor immun respons microenviron tls negat sarcoma lead improv respons pd inhibit twenti metastat sts patient superfici inject lesion treat mg cyclophosphamid cp oral twice daili week week mg pembrolizumab intraven day plan day cycl g g one week intra tumor inject least week maximum week st inject one week cp administr ie day biopsi blood collect pre post treatment patient assess efficaci analysi progress free month month non progress rate ci indic first endpoint studi reach patient increas cell infiltr tumor treatment ratio cdfox p cd treatment decreas case suggest predomin induct treg solubl pdl level baselin also advers outcom g appear modul tumor microenviron signific infiltr cell howev clinic activ combin pd inhibit limit clear correl observ tumor shrinkag increas inflamm tlr stimul might antitumor pro tumor consequencestri registr studi regist clinicaltrialgov number nct	D012509;D051197	T191;T116;T192
36,303,227	extracorpor versus convent cardiopulmonari resuscit refractori hospit cardiac arrest secondari analysi pragu ohca trial surviv rate refractori hospit cardiac arrest ohca remain low convent advanc cardiac life support acl extracorpor life support ecl implant ongo resuscit method call extracorpor cardiopulmonari resuscit ecpr may increas surviv studi examin whether ecpr associ improv outcom	D016887;D004632;D015199;D058687	T061;T058;T046;T093
36,303,226	construct chines indic system public health field investig short term studi hub experi implic increas exchang activ among public health institut expert global call standard oper construct public health field investig short term studi hub field studi hub funcion platform share experi public health develop accur comprehens manner would benefit global practic research aim establish support indic system guid construct work	D011634;D014943	T078;T091
36,303,225	transit protein substitut patient phenylketonuria evalu current practic children phenylketonuria pku transit protein substitut appropri development age essenti help long term accept eas administr assess parent experi transit second stage third stage liquid powder protein substitut patient pku	D010661	T047
36,303,224	multipl de novo copi number variant mdncnv phenomenon present peri zygot dna mutat signatur multilocus pathogen variat multipl de novo copi number variant mdncnv phenotyp describ four constitut de novo cnvs dncnvs aris independ throughout human genom within one generat rare peri zygot mutat event previous report seen everi individu refer genom wide chromosom microarray analysi due congenit abnorm rare famili provid uniqu opportun understand genet factor peri zygot genom instabl impact dncnv human diseas	D056915;D042822	T045;T049;T086
36,303,223	mutat analysi suox isol sulfit oxidas defici ectopia lenti present featur insight genotyp phenotyp correl isol sulfit oxidas defici isod caus sulfit oxidas gene suox mutat rare neurometabol diseas associ ectopia lenti el howev genotyp phenotyp correl establish yet	D004479	T019
36,303,222	determin dimens job satisfact healthcar use factor analysi job satisfact health care great impact affect qualiti product effect healthcar cost fact indic well qualiti life organ employe various link increas perform negat absente turnov better knowledg healthcar employe job satisfact perform direct contribut qualiti servic provid patient critic success organ	D007588;D011788	T078;T041
36,303,221	earli remiss multipl sclerosi link alter coher cerebellar network develop perman disabl multipl sclerosi ms high variabl among patient exact mechan contribut disabl remain unknown	D009103;D020529	T047
36,303,220	preval insuffici iodin intak pregnanc africa systemat review meta analysi fortif foodstuff iodin main iodize salt commenc sever african countri main method mitig iodin defici africa assess degre iodin nutrit pregnanc across africa implement nation iodin fortif program crd	D007455;D044342	T123;T196;T121;T047
36,303,219	strategi de implement low valu care scope review use low valu care lvc persist problem call knowledg strategi de implement howev studi dispers across mani clinic field overview strategi use support de implement lvc extent strategi use implement also use de implement lvc unknown aim scope review identifi strategi de implement lvc describ scientif literatur compar de implement strategi implement strategi specifi expert recommend implement chang eric strategi ad perri et al method scope review conduct accord recommend outlin arksey omalley four scientif databas search relev articl snowbal search journal implement scienc search manual peer review journal articl english articl includ empir studi strategi design reduc use lvc two review conduct abstract full text review conflict decis discuss consensus reach data chart use pilot data chart form strategi first code induct map onto eric compil implement strategi	D000090222;D000077626	T033;T090
36,303,217	practic guid implement success social media recruit strategi lesson eczema monitor onlin trial particip recruit clinic trial remain challeng global increas number social media user acceler use social media modal recruit particular covid pandem tradit recruit method reduc howev limit evid perform social media recruit strategi eczema clinic trial	D000086382;D004485;D061108	T047;T170;T067
36,303,216	alcohol use disord disabl insur switzerland attitud view lawyer insur medic expert addict specialist therapist accord landmark decis swiss feder suprem court peopl substanc use disord sud elig disabl benefit disord impair abil work alcohol use disord aud one common sud switzerland associ high societ econom cost studi aim gain depth understand view profession stakehold group regard aud opinion new legal preced	D000437;D018868	T170;T048
36,303,214	effect pharmaceut compani market mix strategi physician prescrib practic jordan cross section studi explor effect differ market mix strategi physician prescrib practic import due posit effect manag patient diseas improv health status individu promot use cost effect safe treatment patient	D004345;D010820	T097;T093
36,303,212	cytoplasm deliveri sirna use human deriv membran penetr enhanc peptid although protein base method use cell penetr peptid tat expect provid altern approach sirna deliveri low effici endosom escap sirnaprotein complex taken cell endocytosi remain problem overcom problem adopt membran penetr enhanc peptid human syncytin previous identifi laboratori	D057846	T116
36,303,211	develop valid onlin tool assess health care provid manag suspect malaria area transmiss interrupt alert practic health care provid hcps correct manag suspect malaria cmsm vigil central compon malaria surveil follow elimin must establish malaria elimin certif grant studi design develop valid rapid tool simul malaria onlin tool smot evalu hcps practic relat cmsm	D008288	T047
36,303,210	lung microbiom peripher gene express recurr free surviv resect stage ii non small cell lung cancer cancer recurr tumor resect earli stage non small cell lung cancer nsclc common yet difficult predict lung microbiota system immun may import modul risk lung cancer recurr yet biomark lung microbiom peripher immun environ understudi marker may hold promis predict well improv etiolog understand lung cancer recurr	D002289;D008175;D064307	T001;T032;T191;T028
36,303,209	apicoplast ribosom protein vm enhanc artemisinin resist kelch transgen plasmodium falciparum resist plasmodium falciparum artemisinin base art drug front line drug famili use artemisinin base combin therapi act treatment malaria great concern mutat kelch k gene exampl result cystyr cy variant identifi genet marker art resist parasit suggest associ resist mechan howev resist parasit contain k mutat clear greater understand resist mechan requir genom wide associ studi gwas found singl nucleotid polymorph associ art resist fd ferredoxin arp apicoplast ribosom protein mdr multidrug resist protein crt chloroquin resist transport addit k gene mutat suggest allel contribut resist phenotyp import fd arp variant art resist studi sinc protein like function apicoplast locat distinct k	D000962;D016778;D063546;D037621	T026;T121;T047;T109
36,303,208	secondari psychiatr care patient experi internet cbt insomnia qualit studi insomnia common especi among psychiatr patient secondari care experienc h problem affect sever domain life cognit behaviour therapi insomnia cbt wide regard first line treatment often improv comorbid disord despit mani patient offer cbt internet base cbt insomnia icbt effect face face treatment could consider increas avail howev unclear whether icbt suitabl patient sever comorbid psychiatr ill secondari care	D007319;D015928	T061;T184;T047;T048
36,303,207	combin autophagi inhibitor immunoadjuv anti pd l antibodi multifunct nanoparticl enhanc breast cancer immunotherapi applic combin therapi cancer treatment limit due poor tumor specif drug deliveri abscop effect	D001943;D000080873;D053758	T191;T073
36,303,206	use social network video game violent behaviour adolesc among secondari school student basqu countri articl aim explor relationship abus use internet social media involv violent behavior adolesc analysi use sampl particip student enrol secondari educ basqu countri includ lower secondari educ baccalaur studi vocat train cours result studi show antisoci behaviour bulli variabl associ differ categori use inform communic technolog gender differ appear irrelev correl similar boy girl data must taken consider educ communiti shown protect influenc school guidanc depart particular design specif tackl kind situat	D018910	T073
36,303,205	hysteroscop remov intrauterin devic earli pregnanc intrauterin devic iud common use contracept worldwid howev pregnanc patient carri kind devic may occur iud remov woman wish continu pregnanc may challeng manuscript literatur report similar procedur	D007434	T074
36,303,204	whole exom sequenc brugada long qt syndrom reveal novel rare potenti pathogen mutat relat dysfunct cardiac sodium channel brugada syndrom brs long qt syndrom lqts observ inherit primari arrhythmia syndrom channelopathi lead sudden cardiac death	D053840;D008133	T033;T047
36,303,203	igf mediat hypoglycemia paradox appar benign lesion case report review literatur non islet cell tumour hypoglycemia nicth rare encount clinic practic insulin like growth factor igf common caus nicth observ set mesenchym epitheli neoplasia paraneoplast syndrom caus igf activ insulin receptor	D007003;D054364;D010257;D061385	T121;T047;T191
36,303,202	efficaci safeti guselkumab adalimumab pustulot arthro osteiti impact peripher blood immunophenotyp compar treatment effect guselkumab adalimumab patient pustulot arthro osteiti pao addit perform peripher blood immunophenotyp elucid immunolog background analyz impact therapeut drug verifi valid immunolog phenotyp therapeut target	D010000;D011565;D001168	T047
36,303,201	limit handwash facil associ factor sub saharan africa pool preval multilevel analysi sub saharan africa countri demograph health survey data handwash fundament inexpens mean reduc spread communic diseas develop countri mani peopl die due infecti diseas could prevent proper hand hygien recent coronavirus covid pandem threat peopl live resourc limit countri includ sub saharan africa ssa effect hand hygien requir suffici water reliabl sourc prefer access premis access handwash facil water soap enabl hygien behavior therefor studi aim determin preval limit handwash facil associ factor sub saharan africa	D006235;D000086382	T058;T052;T067;T047
36,303,200	classif reconstruct femor bone defect revis asept loosen distal femor endoprosthes year multicent retrospect analysi studi propos system classifi asept loosen distal femor endoprosthes discuss reconstruct method revis surgeri base differ classif type	D006622;D019644	T061;T074
36,303,198	case report anatom transloc tibial insert semitendinosus tendon tibial lengthen common method arthroscop anterior cruciat ligament acl reconstruct use semitendinosus gracili tendon singl tunnel techniqu howev anatom transloc hamstr tendon attach rare	D000070632;D059549;D000070633;D000070598	T061;T023;T037
36,303,197	efficaci platelet rich plasma impregn unidirect porous tricalcium phosphat later lumbar interbodi fusion studi protocol prospect control trial use platelet rich plasma increas spinal fusion surgeri howev efficaci platelet rich plasma later lumbar interbodi fusion unclear japan affino kuraray co tokyo japan tricalcium phosphat artifici bone increas use spinal fusion purpos trial demonstr whether affino impregn platelet rich plasma achiev higher fusion rate better clinic outcom affino alon	D013123;D053657	T061;T031
36,303,196	level tgf vegf pdgf bb pf platelet rich plasma profession soccer player cross section pilot studi regen therapi use platelet rich plasma prp rich sourc growth factor becom popular orthoped sport medicin elit athlet prefer prp therapi injur muscl tendon primarili avoid possibl risk surgic treatment howev clinic effect prp therapi elit athlet compar non athlet remain unknown therefor investig effect prp therapi profession athlet pro athlet focus qualiti prp prepar compar level bioactiv molecul pro athlet non athlet	D012916;D053657	T056;T031
36,303,195	sanfilippo syndrom consensus guidelin clinic care sanfilippo syndrom group rare complex progress neurodegen lysosom storag disord character childhood dementia clinic manag patient progress neurolog declin multisystem involv requir multidisciplinari team experi manag neurodegen disord best practic guidelin clinic manag patient type rare disord critic ensur prompt diagnosi initi appropri care howev publish standard global clinic care guidelin patient sanfilippo syndrom address literatur review conduct evalu current evid base identifi evid gap find review intern steer committe compos clinic expert extens experi manag patient sanfilippo syndrom goal creat consensus set basic clinic guidelin access inform clinician global well provid practic resourc famili share local care team may experi rare diseas review distil guidelin statement easili digest document provid evid base expert led recommend approach common manag challeng appropri monitor schedul care patient sanfilippo syndrom	D009084	T047
36,303,194	combin anterior cruciat later collater ligament reconstruct ipsilater hamstr autograft surgic techniqu differ surgic techniqu propos reconstruct combin anterior cruciat acl later collater ligament lcl although surgic techniqu reliabl reproduc number autolog graft need reconstruct could limit factor especi patient present multi ligament knee injuri posterior cruciat ligament also torn addit techniqu easi master steep learn curv present surgic procedur use last year reconstruct combin acl lcl injuri becom reproduc feasibl time effici procedur approach combin acl lcl injuri use ipsilater hamstr autograft	D000070598;D059549;D017844;D000070632	T061;T023;T037
36,303,192	voic voic qualiti transor co laser surgeri versus singl vocal cord irradi unilater stage glottic larynx cancer random phase iii trial surgeri radiotherapi well establish standard care unilater stage earli stage glottic cancer esgc base compar studi meta analys function oncolog outcom treatment modal similar histor radiotherapi rt perform irradi whole larynx howev involv vocal cord treat recent introduc hypofraction concept result fold smaller target volum retrospect data argu improv voic qualiti non inferior local control base find singl vocal cord irradi svci implement routin approach institut esgc recent year howev prospect data direct compar svci surgeri lack aim voic fill gap	D007822;D053685	T061;T191;T074
36,303,191	prep relat stigma prep use among gay bisexu men sex men ontario british columbia canada aim explor associ prep relat stereotyp perceiv disapprov hereaft prep relat stigma prep use	D000072339;D065129;D015658	T061;T047;T098
36,303,189	develop tripl nanopcr method felin calicivirus felin panleukopenia syndrom virus felin herpesvirus type virus felin calicivirus fcv felin panleukopenia virus fpv felin herpesvirus type fhv three common pathogen cat also main pathogen lead death kitten combin gold nanoparticl convent pcr establish novel tripl nanopcr molecular detect method clinic detect	D017927;D005254;D006564;D006566;D017250;D053768;D018140;D002371	T005;T073;T047
36,303,188	eosinophil mening epidemiolog data nation databas thailand depart diseas control pragmat retrospect analyt studi eosinophil mening eom rare neurolog diseas misdiagnos underdiagnos base report case literatur case worldwid sinc limit data preval trend eom real world set even thailand countri highest preval eom therefor studi aim evalu preval eom eom epidemiolog data real world set	D008581	T047
36,303,187	case report ba subvari show ba like pattern use variant specif pcr assay due singl point mutat downstream spike delet sar cov variant track key genom surveil covid pandem next generat sequenc ngs common use variant determin expens time consum variant specif pcr vspcr faster cheaper method detect specif mutat consid variant defin test usual reli specif amplif mutat present specif melt temperatur peak amplif	D000086402;D000086382	T005;T067;T047
36,303,186	pitfal surgic treatment undiagnos lung lesion cystic pulmonari hydatidosi hydatid cyst mimic mani lung patholog radiolog well malign benign lung tumor may show hydatid cyst like radiolog featur aim studi present clinic experi recommend analyz case creat diagnost difficulti present common radiolog pattern pulmonari hydatid cyst	D004445;D008175;D001994	T019;T047;T191
36,303,185	alcohol consumpt hepatocellular carcinoma novel insight prospect cohort studi nonlinear mendelian random analysi heavi drink well associ increas risk hepatocellular carcinoma hcc wherea effect low moder drink hcc remain debat	D006528;D008113;D014920	T168;T191
36,303,184	bone marrow mesenchym stem cell regul dysfunct nk cell via cell immunoglobulin itim domain patient myelodysplast syndrom myelodysplast syndrom mds clonal diseas hematopoiet cell character hematopoiet cell hematopoiesi high risk transform acut myeloid leukemia aml although under mechan unclear mds often associ immun system disord especi cellular immun abnorm analyz number lymphocyt subset flow cytometri assay explor alter lymphocyt subset mds	D007694;D015470;D059630;D009190	T191;T025;T046
36,303,183	perform onstructur antigen rapid test detect four denv serotyp clinic specimen bangkok thailand dengu arbovir diseas larg effect public health subtrop tropic countri rapid accur detect dengu infect necessari diagnosi diseas manag previous develop high sensit immunochromatograph devic tkk st tkk nd kit base dengu virus denv nonstructur protein detect howev tkk kit evalu main use denv type clinic specimen collect bangladesh valid use clinic specimen serotyp need	D003716;D003715;D000071244;D000071243	T005;T047
36,303,182	inpati care provid perspect develop implement addict medicin consult servic small urban set evalu provid perspect develop implement inpati addict medicin consult servic includ awar servic perceiv role continuum care chang time percept care qualiti inpati substanc use disord	D000073316	T091
36,303,181	attitud toward human milk bank among nativ turkish refuge women resid rural region turkey mix method approach human milk bank hmb play essenti role provid human milk infant would otherwis abl receiv mother milk current donor milk bank turkey new health intervent success determin accept vital first step studi intend determin opinion knowledg attitud nativ turkish refuge women live etep aydn rural area turkey hmb	D017784;D012036	T098;T093
36,303,180	prr promot exosom secret vegf tgf via recruit ddxx stabil raba mrna hepatocellular carcinoma exosom deem import tool intercellular communic cancer cell studi investig role prr long non code rna antisens rna prr regul exosom secret hepatocellular carcinoma hcc cell	D006528;D008113;D055354;D062085;D035683	T026;T123;T191;T114
36,303,179	incid oxygen desatur use high flow nasal cannula versus facemask flexibl bronchoscopi patient risk hypoxemia randomis control trial patient obstruct sleep apnoea osa male sex obes older age hypertens prone hypoxemia flexibl bronchoscopi studi investig whether use high flow nasal cannula hfnc could reduc incid oxygen desatur bronchoscopi deep sedat patient risk hypoxemia	D000072601;D063087	T061;T074
36,303,178	sleepless inequ find behavior risk factor surveil system cross section studi despit larg bodi research advers effect incom inequ date studi examin impact sleep object investig examin associ us state incom inequ odd regular obtain inadequ h inadequ h sleep last h	D012892;D007182	T078;T033;T081;T047;T046
36,303,177	electroconvuls therapi combin lithium develop revers pure anom aphasia case report electroconvuls therapi ect combin mood stabil effect method treatment manic episod howev controversi view side effect	D004565;D001714	T061;T048
36,303,176	determin choic usual sourc care among older peopl cardiovascular diseas china evid studi global age adult health cardiovascular diseas cvd emerg lead contributor death global usual sourc care usc proven generat signific benefit elder cvd understand choic usc would generat import knowledg guid ongo primari care base integr health system build china studi aim analyz individu level determin usc choic among chines elder cvd generat two exemplari patient profil one like choos public hospit usc one like choos public primari care facil usc	D002318	T047
36,303,175	promot health social equiti famili navig prevent earli intervent servic proof concept studi health social inequ associ multipl advers childhood experi includ poverti mental ill child maltreat effect intervent current exist mani health social problem larg segment popul experi barrier access need servic align broader public health effort reduc health social inequ one state usa current studi describ develop format evalu brief low cost portabl model prevent orient famili servic navig call navig way	D005006;D008913	T098;T102
36,303,174	gene clone molecular character thermost chitosanas bacillus cereus ty import conceptu advanc health environ recogn enzym play key role green process industri particular interest chitosanas benefici recycl chitosan resourc produc chitosan oligosaccharid also chitosan gene express molecular character promot understand biolog function bacteri chitosanas well explor chitosanas util chitosan resourc	D001409;D048271	T121;T007;T109
36,303,173	explain experi health care provid regard organiz factor affect health educ qualit studi health educ consid import compon primari health care pay attent organiz factor help improv qualiti health educ therefor present studi conduct explain organiz factor affect health educ among health care provid	D006282;D006761	T093;T073;T097
36,303,172	futur public health emerg disast sustain insight support program healthcar provid mental health healthcar worker hcws forefront throughout covid pandem workplac base support program develop hospit global systemat collect data critic success inform program experi mental healthcar provid mhp support colleagu limit object studi explor experi mhp care hcw colleagu within novel workplac base mental health support program covid pandem provid insight facilit area improv barrier program sustain	D000086382;D004190	T047;T067
36,303,171	lycium barbarum polysaccharid improv dopamin metabol symptom mptp induc model parkinson diseas parkinson diseas pd second common neurodegen diseas middl age elder popul wherea cure pd far novel anim model medic await develop elucid aetiolog pd attenu symptom respect	D010302;D004365	T123;T047;T121
36,303,170	share care call new era rare diseas research develop scientif advanc understand genet mechan mani rare diseas previous unknown etiolog inspir optim patient clinic research communiti hope diseas specif treatment way howev rare diseas communiti reach critic point increas fragment structur oper model threaten abil har full potenti advanc genom comput technolog chang therefor need overcom issu plagu mani rare diseas also support econom viabl therapi develop data silo undermin drug develop fail rare diseas patient orphanet journal rare diseas apr outlin mani broad issu underpin increas fragment silo natur rare diseas space well issu encount communiti repres biomed research general propos sever initi key stakehold includ regul privat public foundat research institut reorient rare diseas ecosystem incent way believ would cultiv acceler innov specif propos support non proprietari patient registri greater data standard global regulatori harmon new busi model encourag data share research collabor default mode leadership need integr across sector drive meaning chang patient industri sponsor academ medic center transform research develop landscap unlock vast healthcar econom scientif potenti rare diseas patient new model ultim goal	D035583;D035843	T062;T047
36,303,169	assess trial repres use serious advers event observ analysi use aggreg individu level data clinic trial routin healthcar data applic randomis control trial pharmacolog agent older peopl frailtymultimorbid often uncertain due concern trial repres howev assess trial repres challeng complex explor approach assess trial repres compar rate trial serious advers event sae rate hospitalisationdeath routin care	D000073496	T033;T184;T046
36,303,168	smartphon rcct onlin repositori random control clinic trial smartphon applic chronic condit chronic health condit big impact disabl morbid mortal worldwid smartphon health applic app improv health patient chronic condit enhanc qualiti effici healthcar number random control trial rcts smartphon health app increas collect avail evid singl databas still miss purpos studi describ smartphon rcct progress databas rcts smartphon app chronic condit	D002908;D063731;D016032	T062;T047;T170
36,303,167	ergonom individu risk factor musculoskelet pain age workforc present studi aim investig possibl associ specif ergonom individu risk factor musculoskelet pain msp back shoulder hip knee region worker age	D059352;D009784;D009140	T033;T047
36,303,166	residenti proxim cropland birth childhood leukaemia domest parent occup pesticid exposur suspect involv occurr childhood acut leukaemia al role exposur agricultur activ littl known previous ecolog studi conduct franc observ increas acut lymphoblast leukaemia incid rate increas viticultur densiti municip resid diagnosi	D010575;D015470;D054198	T131;T191
36,303,165	malaria pregnanc control pregnanc outcom decad overview use ghana dhim ii data malaria pregnanc control intervent implement antenat care servic decad ghana uptak intervent seen steadi improv year occur within context decreas global trend malaria infect confirm decreas malaria pregnanc preval ghana howev much known improv intervent uptak reduct malaria infect preval impact pregnanc outcom countri studi aim describ trend matern anaemia low birth weight preval uptak malaria pregnanc control intervent last decad use data ghana district health inform manag system dhim ii	D000740;D000962;D008288;D015597	T121;T047
36,303,164	enrich prevotella intermedia human colorect cancer addit effect fusobacterium nucleatum malign transform colorect adenoma owe heterogen microbiota among individu popul fusobacterium nucleatum bacteroid fragili report enrich colorect cancer crc multipl studi thus discoveri addit bacteria contribut crc develop various popul expect aim identifi bacteria associ progress colorect adenoma carcinoma determin contribut bacteria malign transform patient han chines origin	D000236;D015179;D000230;D018256	T191
36,303,163	narrat review moder effect repercuss exercis intervent osteoporosi ingeni involv gut microbiota metabolit osteoporosi op system bone diseas character decreas bone mass destruct bone microstructur tend result enhanc bone fragil relat fractur well high disabl rate mortal exercis one common reliabl cost effect intervent prevent treatment op current numer studi reveal close associ gut microbiota gm bone metabol recent moreov exercis alter structur composit abund gm influenc bodi health via gm metabolit chang gm also depend choic exercis mode herein combin relev studi base insepar relationship exercis intervent gm op review aim discuss moder effect potenti mechan exercis intervent gm bone metabol well interact	D000069196;D010024	T047;T007;T001
36,303,162	transcriptom base network analysi relat like tumor associ macrophag infiltr identifi var potenti target improv melanoma immunotherapi efficaci like tumor associ macrophag tam independ prognost factor melanoma	D000084582;D008545	T191;T025
36,303,160	observ studi effect smoke cessat earlier clinic characterist cours acut exacerb chronic obstruct pulmonari diseas previous studi focus negat effect continu smoke chronic obstruct pulmonari diseas copd howev studi investig posit effect long term smoke cessat patient suffer acut exacerb copd	D016540;D029424	T055;T047
36,303,159	adher opioid agonist therapi predict uptak direct act antivir peopl use drug result french nation healthcar databas anr fantasio studi opioid agonist therapi oat associ reduc inject reduc hcv transmiss opportun initi hepat c virus hcv treatment peopl use drug pwud aim studi extent adher oat predict increas uptak direct act antivir daa pwud chronic hcv infect	D019698;D006526	T047
36,303,158	ttcc potenti target treatment lung cancer novel ttc gene tetratricopeptid repeat domain c ttcc main mediat interact protein involv progress various tumor studi determin effect ttcc lung adenocarcinoma found might use potenti intervent target	D008175;D000077192	T191
36,303,157	novel aquaporin associ optic neuriti rat model sever patholog function manifest optic neuriti common manifest aquaporin aqp antibodi seroposit neuromyel optica nmo extent tissu damag frequent sever often lead loss visual function curat treatment condit develop novel therapeut strategi elucid under patholog mechan use clinic relev experiment model necessari howev previous anim model result mild lesion limit function impair present studi attempt establish feasibl model sever patholog function manifest use high affin anti aqp antibodi subsequ aim address whether model suitabl potenti drug evalu test effect minocyclin well known microgliamacrophag inhibitor	D009902;D009471	T047
36,303,156	cognit enhanc supplement medic unit state resid physician use cognit enhanc medic supplement among healthi adult continu rise limit data exist use among resid physician given high competit stress lifestyl sought evalu preval motiv side effect use cognit enhanc supplement medic among resid physician larg unit state academ institut	D007396;D010820	T065;T097
36,303,155	role occup physician workplac covid pandem japan qualit interview studi coronavirus diseas covid pandem various impact busi worker worldwid spread infect report cluster outbreak workplac world health organ emphas workplac infect control measur occup physician op expect activ support employ effort minim damag pandem howev littl research role specialist pandem clarif contribut op health safeti workplac covid pandem would benefici ensur op effect deploy next pandem	D000086382;D016272;D010820	T078;T091;T067;T097;T047
36,303,154	genet mechan under increas microalg thermotoler maxim growth rate yield light follow adapt laboratori evolut adapt laboratori evolut ale power method strain optim toward abiot stress factor identifi adapt mechan studi green microalga picochlorum sp bpe cultur supra optim temperatur forc genet adapt robust adapt capac picochlorum strain turn emerg model evolutionari studi abiot stressor temperatur salin light	D058086;D000071436;D000460	T039;T002;T204
36,303,153	heterogen pragmat randomis trial sourc manag pragmat trial aim generat evid direct inform patient caregiv health system manag polici decis heterogen patient characterist contribut heterogen respons intervent howev mani sourc heterogen outcom base expertis judgement author identifi differ sourc clinic methodolog heterogen translat heterogen patient respons consid desir undesir discuss use real world trial exampl illustr heterogen manag whole cours trial	D064792;D016032;D012107	T062;T170;T096;T081;T169
36,303,152	parent cope uncertainti along sever combin immunodefici journey sever combin immunodefici scid group rare genet disord caus disrupt immun system function parent children scid experi mani uncertainti relat child diagnosi treatment recoveri qualiti life fulli understand parent experi throughout scid journey import explor stressor generat uncertainti parent cope stressor	D011788;D016511	T078;T047
36,303,151	preval pattern migrat intent doctor undergo train programm public tertiari hospit ekiti state nigeria emigr nigerian doctor includ undergo train develop countri europ america reach alarm rate	D033182;D007396	T065;T097;T041
36,303,150	adeno associ virus base caveolin deliveri via differ rout prevent cholesterol gallston format hepat caveolin cav reduc cholesterol gallston diseas cgd mice cav defici prone develop cgd howev remain unknown whether restor hepat cav express prevent develop cgd	D051242;D042882	T123;T116;T031;T192
36,303,149	clinic featur outcom congenit chylothorax singl tertiari medic center experi china congenit chylothorax cc uncommon congenit diseas object studi analyz clinic featur treatment outcom infant cc chines tertiari medic center	D002916;D010996	T047
36,303,148	associ overal dietari qualiti constip american adult cross section studi constip serious affect peopl life qualiti dietari adjust one effect method overal dietari qualiti report associ diseas associ constip report studi aim explor associ overal dietari qualiti constip	D004032;D014675	T168
36,303,147	climat driven mosquito born viral suitabl index measur risk transmiss dengu chikungunya zika mexico climat variabl influenc popul dynam aed aegypti mosquito transmit virus caus dengu chikungunya zika recent year diseas grown consider dengu fastest grow mosquito transmit diseas worldwid put per cent global popul risk effect antivir treatment vaccin wide avail control mosquito popul remain one effect way prevent epidem paper analys tempor spatial dynam dengu mexico chikungunya zika sinc first appear countri respect studi aim evalu season climatolog variabl affect potenti risk transmiss mosquito born diseas mexico among world endem countri term dengu given high incid mosquito born diseas size wide rang climat good case studi	D065632;D003715;D002646;D003716;D000071244;D000071243;D000330;D005416	T047;T005;T204
36,303,146	crosstalk circadian clock plant rhizomicrobiom circadian clock occur across kingdom life includ fungi bacteria present root associ soil known rhizospher recent work ami newman colleagu publish bmc biolog discov circadian clock arabidopsi plant affect rhythmic rhizospher microbi communiti bring play excit question whether bidirect rhythmic interact plant rhizomicrobiom discuss find newman et al suggest soil microbiom self sustain plant impos rhythmic challeng plant microbiom circadian clock research	D057906;D064307;D017360	T032;T040;T002;T028;T001
36,303,145	effect fix orthodont applianc gingiv status oral microbiota pilot studi pilot studi aim investig fix orthodont applianc simultan appli upper lower arch affect oral environ medium term	D003773;D064307	T001;T047;T032;T028
36,303,144	dnmta rh mutat drive daunorubicin resist acut myeloid leukemia via regul nrfnqo pathway dna methyltransferas dnmta often mutat arginin dnmta r acut myeloid leukemia aml aml patient dnmta r mutat usual resist daunorubicin treatment howev associ mechan still unclear therefor urgent investig daunorubicin resist aml patient dnmta r mutant	D004248;D015470;D016660;D051267	T123;T191;T126;T116
36,303,143	qualiti life among cervic cancer patient follow complet chemoradiotherapi ocean road cancer institut orci tanzania effect cancer treatment involv aggress chemo radiotherapi protocol alter survivor qualiti life qol recent arous attent focus clinic care rather holist client center look beyond morbid mortal studi assess qol associ factor among patient cervic cancer cc complet chemoradiotherapi	D011788;D002583	T078;T191
36,303,142	effect accept evid synthesi summari format clinic guidelin develop group mix method systemat review clinic guidelin develop often involv rigor synthesi evid involv multidisciplinari stakehold differ prioriti knowledg evid synthesi make communic find complex summari format typic use communic result evid synthes howev littl consensus format effect accept differ stakehold	D036301	T062
36,303,141	role area level social depriv childhood adolesc consult rate primari care popul base cohort studi studi show children adolesc social depriv area sda consult general practition gp often least social depriv area non sda given gps see wide rang diseas import know clinic diagnos shape socioeconom factor primari object determin associ area level social depriv consult rate pediatr popul secondari object explor associ across wide rang clinic diagnos	D000091489;D012017	T170;T097;T081;T068;T058
36,303,139	cultur adapt guidelin offer mental health first aid person potenti traumat event delphi expert consensus studi brazil traumat event increas risk mental disord countri relat develop mental health support system servic assist peopl experienc potenti traumat event may unavail situat peopl communiti becom key sourc support howev alway knowledg skill offer effect help studi report cultur adapt brazil english languag mental health first aid guidelin help someon experienc potenti traumat event	D005392;D008603	T061;T041

36,303,279

quantit spatial map tissu water lipid content use spatial frequenc domain imag nm wavelength region significancewat lipid key particip mani biolog process label free non contact optic method spatial map compon vivo shortwav infrar meso pattern imag swir mpi emerg techniqu success address need howev requir dedic swir camera probe nm wavelength region hinder practic translat technologyaimcompar swir mpi aim develop new techniqu dramat reduc cost detector maintain high accuraci quantif tissu water lipid contentapproachbi util water lipid absorpt featur nm wavelength region well optim wavelength spatial frequenc combin develop new imag techniqu base spatial frequenc domain imag quantit map tissu water lipid content use regular silicon base cameraresultsth propos method valid phantom studi show averag error water content estim lipid content estim respect propos method also demonstr ex vivo porcin tissu lipid map well vivo longitudin water content monitoringconclusionsth propos techniqu enabl spatial map tissu water lipid content cost detector reduc two order magnitud compar swir mpi maintain high accuraci experiment result highlight potenti techniqu substanti impact scientif industri applic

D014867;D003952

T060;T121;T197

36,303,257

relationship lipoprotein risk cardiovascular diseas mendelian random analysi lipoprotein lp one residu risk factor cardiovascular diseas cvd set optim low densiti lipoprotein cholesterol ldl c associ lp cvd still exploratori phase studi indic causal connect lp various cvd

D002318;D020521

T047

36,303,256

role time perspect self control well ill covid pandem multipl mediat model grow bodi evid indic outbreak covid signific influenc individu cognit emot psycholog health studi aim explor effect associ time perspect self control well ill among colleg student china covid pandem

D000086382;D000068356

T055;T047;T067

36,303,255

season distribut cryptosporidium spp giardia duodenali enterocytozoon bieneusi tibetan sheep qinghai china cryptosporidium spp giardia duodenali enterocytozoon bieneusi caus import intestin diseas rumin howev data distribut three protozoan pathogen tibetan sheep limit

D021862;D016829;D003458;D003457;D005873;D016881

T047;T004;T204

36,303,253

associ hkme breast cancer prognosi estrogen receptor status cellular experi reveal decreas histon h lysin trimethyl hkme level associ upregul oncogen breast cancer cell moreov role hkme breast cancer close associ estrogen receptor er status therefor aim examin prognost valu hkme breast cancer er status level hkme tumor evalu tissu microarray immunohistochemistri women diagnos primari invas breast cancer hazard ratio hrs confid interv cis overal surviv os progress free surviv pfs estim use cox regress model interact hkme er prognosi assess multipl scale

D001943

T191

36,303,252

remark low host specif bat fli penicillidia fulvida diptera nycteribiida assess mitochondri coi nuclear sequenc data recognit delin morpholog indistinguish cryptic speci broad implic wildlif conserv diseas ecolog accur estim biodivers parasit intrigu studi cryptic speciat uniqu evolutionari pressur diversifi factor generat ecolog characterist host parasit relationship includ host specif bat fli diptera nycteribiida streblida oblig hematophag ectoparasit bat general exhibit high host specif one rare except penicillidia fulvida diptera nycteribiida african bat fli found associ mani phylogenet distant host one explan p fulvida extrem polyxeni may repres complex host specif yet cryptic speci increas common find molecular genet studi suppos generalist parasit

D004175;D002685

T015;T204

36,303,251

expert group consensus earli diagnosi manag infantil onset pomp diseas gulf region infantil onset pomp diseas iopd rare devast autosom recess lysosom storag disord manifest immedi birth sever iopd case completealmost complet acid alpha glucosidas enzym defici observ consid rapid progress diseas time diagnosi treatment import even slight delay remark alter cours diseas enzym replac therapi ert recombin human acid alpha glucosidas safe benefici iopd patient howev heterogen patient respons ert factor influenc treatment effect includ patient age time treatment initi pre exist muscl damag cross reactiv immunolog materi crim status baselin immunomodul along ert recent develop therapeut approach includ therapeut armamentarium iopd optim clinic benefit particular crim negat iopd patient howev dearth publish data earli diagnosi clinic posit immunomodul protocol along ert treatment iopd gulf region

D006009

T047

36,303,246

under molecular mechan biomark plaqu vulner base bioinformat analysi studi aim identifi under differenti express gene deg mechan unstabl atherosclerot plaqu use bioinformat method

D058226;D050197

T047;T046;T020;T031

36,303,243

protocol develop core outcom set laparoscop hiatal hernia repair hiatal hernia negat damag patient health life qualiti laparoscop hiatal hernia repair current gold standard treatment hiatal hernia lhhr numer clinic trial laparoscop hiatal hernia repair done publish find high variabl due lack uniqu outcom set basic outcom set ever establish previous decad procedur hiatal hernia repair yet protocol outlin procedur develop core outcom set laparoscop hiatal hernia repair cos lhhr cos lhhr provid uniqu criteria clinic investig

D010535;D006551

T060;T047;T061

36,303,242

heat labil enterotoxin enhanc f produc enterotoxigen e coli adhes porcin intestin epitheli cell upregul bacteri adhesin stb enterotoxin one crucial enterotoxin secret enterotoxigen escherichia coli etec heat labil enterotoxin lt enhanc bacteri adher vivo vitro howev under mechan remain unclear address evalu adher lt produc lt defici etec strain use ipec j cell model express level inflammatori cytokin chemokin tight junction protein evalu ipec j cell infect various etec strain level adhesin enterotoxin also evalu fac produc etec f etec strain treatment cyclic amp camp adher eltab mutant decreas compar wild type strain wherea adher pbr eltab strain mark increas compar parent strain product lt regul express tnf il cxcl il gene howev appear affect tight junction protein express import found camp lead upregul adhesin product stb enterotoxin moreov f etec strain treat camp also greater adhes ipec j cell adher faeg flic estb mutant decreas result indic lt enhanc adher f etec due primarili upregul f fimbria flagellin stb enterotoxin express provid insight pathogen mechan lt etec

D003967;D054307;D004768;D004927;D029968;D013553

T184;T123;T007;T116;T131;T047

36,303,240

bobbl head doll syndrom infant arachnoid cyst case report bobbl head doll syndrom rare uniqu movement disord common affect children younger year age character continu episod movement frequenc hz exact mechan bobbl head doll syndrom elucid endoscop ventriculocisternostomi optim treatment option literatur review less case bobbl head doll syndrom suprasellar arachnoid cyst

D016080;D020820;D006849;D020542

T184;T030;T033;T019;T047

36,303,237

readi yet limit state art diseas name entiti recogn intens research done area biomed natur languag process sinc breakthrough transfer learn base method bert model use varieti biomed clinic applic avail data set model show excel result part exceed inter annot agreement howev biomed name entiti recognit appli covid preprint show perform drop compar result test data question aris well train model abl predict complet new data ie general

D057225;D000086382

T047;T067;T066

36,303,236

difficulti facial emot recognit take psychopath alexithym trait account alexithym psychopath trait close associ distinct construct associ facial emot process deficit reflect empathi deficit howev under mechan contribut deficit well understood

D000066499

T041

36,303,235

oral anticoagul systemat overview review efficaci safeti genotyp self monitor stakehold experi systemat overview commiss england depart health social care dhsc assess evid direct previous novel oral anticoagul oac compar usual care adult prevent stroke relat atrial fibril af prevent treat venous thromboembol vte specif assess efficaci safeti genotyp self monitor patient clinician experi oac

D001281;D020521;D054556

T047;T046

36,303,234

alter bacteriom mycobiom metabolom characterist pcos patient normaloverweight individu character gut bacteriom mycobiom serum metabolom profil polycyst ovari syndrom pcos patient normaloverweight individu evalu potenti microbiota relat diagnost method develop pcos rrna gene sequenc use fecal sampl metabolom analysi serum sampl conduct pcos classifi base multiom marker construct signific bacteri fungal communiti metabolit differ among pcos patient healthi volunt normaloverweight individu healthi individu overweightobes display less abnorm metabol pcos patient uniqu higher abund fungal genus mortierella nine bacteri genera predict pathway fungal genera top metabolit screen distinguish pcos healthi control auc respect metabolit deriv model accur microb base model discrimin normal bmi pcos pcos lb normal bmi healthi healthi lb pcos hb healthi hb featur bacteria fungi predict pathway serum metabolit display higher associ free androgen index fai cooccurr network conclus data reveal hyperandrogenemia play central role dysbiosi intestin microecolog chang metabol status patient pcos effect exceed role bmi healthi women high bmi show uniqu microbiota metabol featuresth prioriti predict model discrimin pcos healthi status studi serum metabolit fungal taxa bacteri taxa

D011085;D000072761

T047;T004

36,303,231

insulin like peptid insl posit correl anti mllerian hormon amh women polycyst ovari syndrom case control studi insulin like peptid insl involv reproduct metabol process polycyst ovari syndrom pcos studi aim evalu relationship insl anti mllerian hormon amh

D054304;D011085

T125;T121;T047;T116

36,303,230

serum mmp sp vegf level reflect sever connect tissu diseas associ interstiti lung diseas interstiti lung diseas ild common pulmonari complic connect tissu diseas ctd studi aim evalu clinic diagnost valu matrix metalloproteinas mmp surfact protein sp vascular endotheli growth factor vegf potenti biomark ctd ild

D017563;D003240

T047

36,303,229

tim downregul toxoplasma gondii infect contribut decidu dendrit cell dysfunct women earli pregnanc infect toxoplasma gondii may sever advers pregnanc outcom spontan abort fetal malform inhibitori molecul cell immunoglobulin mucin domain tim high express decidu dendrit cell ddcs play import role maintain immun toler howev whether gondii infect caus ddc dysfunct influenc express tim particip advers pregnanc outcom still unclear

D003713;D000072597;D014123

T047;T116;T025;T192

36,303,228

pembrolizumab combin low dose cyclophosphamid intra tumor inject toll like receptor agonist g patient advanc pretreat soft tissu sarcoma result pembrosarc basket studi soft tissu sarcoma sts heterogen mesenchym tumor limit therapeut option advanc set immun checkpoint inhibitor shown signific clinic activ inflam sts character presenc tertiari lymphoid structur tls new strategi need sensit tls negat sts immunotherapi engag toll like receptor tlr signal pathway contribut develop favor tumor microenviron solid tumor g high potent toll like receptor tlr agonist hypothes intra tumor g would induc robust local potenti system anti tumor immun respons microenviron tls negat sarcoma lead improv respons pd inhibit twenti metastat sts patient superfici inject lesion treat mg cyclophosphamid cp oral twice daili week week mg pembrolizumab intraven day plan day cycl g g one week intra tumor inject least week maximum week st inject one week cp administr ie day biopsi blood collect pre post treatment patient assess efficaci analysi progress free month month non progress rate ci indic first endpoint studi reach patient increas cell infiltr tumor treatment ratio cdfox p cd treatment decreas case suggest predomin induct treg solubl pdl level baselin also advers outcom g appear modul tumor microenviron signific infiltr cell howev clinic activ combin pd inhibit limit clear correl observ tumor shrinkag increas inflamm tlr stimul might antitumor pro tumor consequencestri registr studi regist clinicaltrialgov number nct

D012509;D051197

T191;T116;T192

36,303,227

extracorpor versus convent cardiopulmonari resuscit refractori hospit cardiac arrest secondari analysi pragu ohca trial surviv rate refractori hospit cardiac arrest ohca remain low convent advanc cardiac life support acl extracorpor life support ecl implant ongo resuscit method call extracorpor cardiopulmonari resuscit ecpr may increas surviv studi examin whether ecpr associ improv outcom

D016887;D004632;D015199;D058687

T061;T058;T046;T093

36,303,226

construct chines indic system public health field investig short term studi hub experi implic increas exchang activ among public health institut expert global call standard oper construct public health field investig short term studi hub field studi hub funcion platform share experi public health develop accur comprehens manner would benefit global practic research aim establish support indic system guid construct work

D011634;D014943

T078;T091

36,303,225

transit protein substitut patient phenylketonuria evalu current practic children phenylketonuria pku transit protein substitut appropri development age essenti help long term accept eas administr assess parent experi transit second stage third stage liquid powder protein substitut patient pku

D010661

T047

36,303,224

multipl de novo copi number variant mdncnv phenomenon present peri zygot dna mutat signatur multilocus pathogen variat multipl de novo copi number variant mdncnv phenotyp describ four constitut de novo cnvs dncnvs aris independ throughout human genom within one generat rare peri zygot mutat event previous report seen everi individu refer genom wide chromosom microarray analysi due congenit abnorm rare famili provid uniqu opportun understand genet factor peri zygot genom instabl impact dncnv human diseas

D056915;D042822

T045;T049;T086

36,303,223

mutat analysi suox isol sulfit oxidas defici ectopia lenti present featur insight genotyp phenotyp correl isol sulfit oxidas defici isod caus sulfit oxidas gene suox mutat rare neurometabol diseas associ ectopia lenti el howev genotyp phenotyp correl establish yet

D004479

T019

36,303,222

determin dimens job satisfact healthcar use factor analysi job satisfact health care great impact affect qualiti product effect healthcar cost fact indic well qualiti life organ employe various link increas perform negat absente turnov better knowledg healthcar employe job satisfact perform direct contribut qualiti servic provid patient critic success organ

D007588;D011788

T078;T041

36,303,221

earli remiss multipl sclerosi link alter coher cerebellar network develop perman disabl multipl sclerosi ms high variabl among patient exact mechan contribut disabl remain unknown

D009103;D020529

T047

36,303,220

preval insuffici iodin intak pregnanc africa systemat review meta analysi fortif foodstuff iodin main iodize salt commenc sever african countri main method mitig iodin defici africa assess degre iodin nutrit pregnanc across africa implement nation iodin fortif program crd

D007455;D044342

T123;T196;T121;T047

36,303,219

strategi de implement low valu care scope review use low valu care lvc persist problem call knowledg strategi de implement howev studi dispers across mani clinic field overview strategi use support de implement lvc extent strategi use implement also use de implement lvc unknown aim scope review identifi strategi de implement lvc describ scientif literatur compar de implement strategi implement strategi specifi expert recommend implement chang eric strategi ad perri et al method scope review conduct accord recommend outlin arksey omalley four scientif databas search relev articl snowbal search journal implement scienc search manual peer review journal articl english articl includ empir studi strategi design reduc use lvc two review conduct abstract full text review conflict decis discuss consensus reach data chart use pilot data chart form strategi first code induct map onto eric compil implement strategi

D000090222;D000077626

T033;T090

36,303,217

practic guid implement success social media recruit strategi lesson eczema monitor onlin trial particip recruit clinic trial remain challeng global increas number social media user acceler use social media modal recruit particular covid pandem tradit recruit method reduc howev limit evid perform social media recruit strategi eczema clinic trial

D000086382;D004485;D061108

T047;T170;T067

36,303,216

alcohol use disord disabl insur switzerland attitud view lawyer insur medic expert addict specialist therapist accord landmark decis swiss feder suprem court peopl substanc use disord sud elig disabl benefit disord impair abil work alcohol use disord aud one common sud switzerland associ high societ econom cost studi aim gain depth understand view profession stakehold group regard aud opinion new legal preced

D000437;D018868

T170;T048

36,303,214

effect pharmaceut compani market mix strategi physician prescrib practic jordan cross section studi explor effect differ market mix strategi physician prescrib practic import due posit effect manag patient diseas improv health status individu promot use cost effect safe treatment patient

D004345;D010820

T097;T093

36,303,212

cytoplasm deliveri sirna use human deriv membran penetr enhanc peptid although protein base method use cell penetr peptid tat expect provid altern approach sirna deliveri low effici endosom escap sirnaprotein complex taken cell endocytosi remain problem overcom problem adopt membran penetr enhanc peptid human syncytin previous identifi laboratori

D057846

T116

36,303,211

develop valid onlin tool assess health care provid manag suspect malaria area transmiss interrupt alert practic health care provid hcps correct manag suspect malaria cmsm vigil central compon malaria surveil follow elimin must establish malaria elimin certif grant studi design develop valid rapid tool simul malaria onlin tool smot evalu hcps practic relat cmsm

D008288

T047

36,303,210

lung microbiom peripher gene express recurr free surviv resect stage ii non small cell lung cancer cancer recurr tumor resect earli stage non small cell lung cancer nsclc common yet difficult predict lung microbiota system immun may import modul risk lung cancer recurr yet biomark lung microbiom peripher immun environ understudi marker may hold promis predict well improv etiolog understand lung cancer recurr

D002289;D008175;D064307

T001;T032;T191;T028

36,303,209

apicoplast ribosom protein vm enhanc artemisinin resist kelch transgen plasmodium falciparum resist plasmodium falciparum artemisinin base art drug front line drug famili use artemisinin base combin therapi act treatment malaria great concern mutat kelch k gene exampl result cystyr cy variant identifi genet marker art resist parasit suggest associ resist mechan howev resist parasit contain k mutat clear greater understand resist mechan requir genom wide associ studi gwas found singl nucleotid polymorph associ art resist fd ferredoxin arp apicoplast ribosom protein mdr multidrug resist protein crt chloroquin resist transport addit k gene mutat suggest allel contribut resist phenotyp import fd arp variant art resist studi sinc protein like function apicoplast locat distinct k

D000962;D016778;D063546;D037621

T026;T121;T047;T109

36,303,208

secondari psychiatr care patient experi internet cbt insomnia qualit studi insomnia common especi among psychiatr patient secondari care experienc h problem affect sever domain life cognit behaviour therapi insomnia cbt wide regard first line treatment often improv comorbid disord despit mani patient offer cbt internet base cbt insomnia icbt effect face face treatment could consider increas avail howev unclear whether icbt suitabl patient sever comorbid psychiatr ill secondari care

D007319;D015928

T061;T184;T047;T048

36,303,207

combin autophagi inhibitor immunoadjuv anti pd l antibodi multifunct nanoparticl enhanc breast cancer immunotherapi applic combin therapi cancer treatment limit due poor tumor specif drug deliveri abscop effect

D001943;D000080873;D053758

T191;T073

36,303,206

use social network video game violent behaviour adolesc among secondari school student basqu countri articl aim explor relationship abus use internet social media involv violent behavior adolesc analysi use sampl particip student enrol secondari educ basqu countri includ lower secondari educ baccalaur studi vocat train cours result studi show antisoci behaviour bulli variabl associ differ categori use inform communic technolog gender differ appear irrelev correl similar boy girl data must taken consider educ communiti shown protect influenc school guidanc depart particular design specif tackl kind situat

D018910

T073

36,303,205

hysteroscop remov intrauterin devic earli pregnanc intrauterin devic iud common use contracept worldwid howev pregnanc patient carri kind devic may occur iud remov woman wish continu pregnanc may challeng manuscript literatur report similar procedur

D007434

T074

36,303,204

whole exom sequenc brugada long qt syndrom reveal novel rare potenti pathogen mutat relat dysfunct cardiac sodium channel brugada syndrom brs long qt syndrom lqts observ inherit primari arrhythmia syndrom channelopathi lead sudden cardiac death

D053840;D008133

T033;T047

36,303,203

igf mediat hypoglycemia paradox appar benign lesion case report review literatur non islet cell tumour hypoglycemia nicth rare encount clinic practic insulin like growth factor igf common caus nicth observ set mesenchym epitheli neoplasia paraneoplast syndrom caus igf activ insulin receptor

D007003;D054364;D010257;D061385

T121;T047;T191

36,303,202

efficaci safeti guselkumab adalimumab pustulot arthro osteiti impact peripher blood immunophenotyp compar treatment effect guselkumab adalimumab patient pustulot arthro osteiti pao addit perform peripher blood immunophenotyp elucid immunolog background analyz impact therapeut drug verifi valid immunolog phenotyp therapeut target

D010000;D011565;D001168

T047

36,303,201

limit handwash facil associ factor sub saharan africa pool preval multilevel analysi sub saharan africa countri demograph health survey data handwash fundament inexpens mean reduc spread communic diseas develop countri mani peopl die due infecti diseas could prevent proper hand hygien recent coronavirus covid pandem threat peopl live resourc limit countri includ sub saharan africa ssa effect hand hygien requir suffici water reliabl sourc prefer access premis access handwash facil water soap enabl hygien behavior therefor studi aim determin preval limit handwash facil associ factor sub saharan africa

D006235;D000086382

T058;T052;T067;T047

36,303,200

classif reconstruct femor bone defect revis asept loosen distal femor endoprosthes year multicent retrospect analysi studi propos system classifi asept loosen distal femor endoprosthes discuss reconstruct method revis surgeri base differ classif type

D006622;D019644

T061;T074

36,303,198

case report anatom transloc tibial insert semitendinosus tendon tibial lengthen common method arthroscop anterior cruciat ligament acl reconstruct use semitendinosus gracili tendon singl tunnel techniqu howev anatom transloc hamstr tendon attach rare

D000070632;D059549;D000070633;D000070598

T061;T023;T037

36,303,197

efficaci platelet rich plasma impregn unidirect porous tricalcium phosphat later lumbar interbodi fusion studi protocol prospect control trial use platelet rich plasma increas spinal fusion surgeri howev efficaci platelet rich plasma later lumbar interbodi fusion unclear japan affino kuraray co tokyo japan tricalcium phosphat artifici bone increas use spinal fusion purpos trial demonstr whether affino impregn platelet rich plasma achiev higher fusion rate better clinic outcom affino alon

D013123;D053657

T061;T031

36,303,196

level tgf vegf pdgf bb pf platelet rich plasma profession soccer player cross section pilot studi regen therapi use platelet rich plasma prp rich sourc growth factor becom popular orthoped sport medicin elit athlet prefer prp therapi injur muscl tendon primarili avoid possibl risk surgic treatment howev clinic effect prp therapi elit athlet compar non athlet remain unknown therefor investig effect prp therapi profession athlet pro athlet focus qualiti prp prepar compar level bioactiv molecul pro athlet non athlet

D012916;D053657

T056;T031

36,303,195

sanfilippo syndrom consensus guidelin clinic care sanfilippo syndrom group rare complex progress neurodegen lysosom storag disord character childhood dementia clinic manag patient progress neurolog declin multisystem involv requir multidisciplinari team experi manag neurodegen disord best practic guidelin clinic manag patient type rare disord critic ensur prompt diagnosi initi appropri care howev publish standard global clinic care guidelin patient sanfilippo syndrom address literatur review conduct evalu current evid base identifi evid gap find review intern steer committe compos clinic expert extens experi manag patient sanfilippo syndrom goal creat consensus set basic clinic guidelin access inform clinician global well provid practic resourc famili share local care team may experi rare diseas review distil guidelin statement easili digest document provid evid base expert led recommend approach common manag challeng appropri monitor schedul care patient sanfilippo syndrom

D009084

T047

36,303,194

combin anterior cruciat later collater ligament reconstruct ipsilater hamstr autograft surgic techniqu differ surgic techniqu propos reconstruct combin anterior cruciat acl later collater ligament lcl although surgic techniqu reliabl reproduc number autolog graft need reconstruct could limit factor especi patient present multi ligament knee injuri posterior cruciat ligament also torn addit techniqu easi master steep learn curv present surgic procedur use last year reconstruct combin acl lcl injuri becom reproduc feasibl time effici procedur approach combin acl lcl injuri use ipsilater hamstr autograft

D000070598;D059549;D017844;D000070632

T061;T023;T037

36,303,192

voic voic qualiti transor co laser surgeri versus singl vocal cord irradi unilater stage glottic larynx cancer random phase iii trial surgeri radiotherapi well establish standard care unilater stage earli stage glottic cancer esgc base compar studi meta analys function oncolog outcom treatment modal similar histor radiotherapi rt perform irradi whole larynx howev involv vocal cord treat recent introduc hypofraction concept result fold smaller target volum retrospect data argu improv voic qualiti non inferior local control base find singl vocal cord irradi svci implement routin approach institut esgc recent year howev prospect data direct compar svci surgeri lack aim voic fill gap

D007822;D053685

T061;T191;T074

36,303,191

prep relat stigma prep use among gay bisexu men sex men ontario british columbia canada aim explor associ prep relat stereotyp perceiv disapprov hereaft prep relat stigma prep use

D000072339;D065129;D015658

T061;T047;T098

36,303,189

develop tripl nanopcr method felin calicivirus felin panleukopenia syndrom virus felin herpesvirus type virus felin calicivirus fcv felin panleukopenia virus fpv felin herpesvirus type fhv three common pathogen cat also main pathogen lead death kitten combin gold nanoparticl convent pcr establish novel tripl nanopcr molecular detect method clinic detect

D017927;D005254;D006564;D006566;D017250;D053768;D018140;D002371

T005;T073;T047

36,303,188

eosinophil mening epidemiolog data nation databas thailand depart diseas control pragmat retrospect analyt studi eosinophil mening eom rare neurolog diseas misdiagnos underdiagnos base report case literatur case worldwid sinc limit data preval trend eom real world set even thailand countri highest preval eom therefor studi aim evalu preval eom eom epidemiolog data real world set

D008581

T047

36,303,187

case report ba subvari show ba like pattern use variant specif pcr assay due singl point mutat downstream spike delet sar cov variant track key genom surveil covid pandem next generat sequenc ngs common use variant determin expens time consum variant specif pcr vspcr faster cheaper method detect specif mutat consid variant defin test usual reli specif amplif mutat present specif melt temperatur peak amplif

D000086402;D000086382

T005;T067;T047

36,303,186

pitfal surgic treatment undiagnos lung lesion cystic pulmonari hydatidosi hydatid cyst mimic mani lung patholog radiolog well malign benign lung tumor may show hydatid cyst like radiolog featur aim studi present clinic experi recommend analyz case creat diagnost difficulti present common radiolog pattern pulmonari hydatid cyst

D004445;D008175;D001994

T019;T047;T191

36,303,185

alcohol consumpt hepatocellular carcinoma novel insight prospect cohort studi nonlinear mendelian random analysi heavi drink well associ increas risk hepatocellular carcinoma hcc wherea effect low moder drink hcc remain debat

D006528;D008113;D014920

T168;T191

36,303,184

bone marrow mesenchym stem cell regul dysfunct nk cell via cell immunoglobulin itim domain patient myelodysplast syndrom myelodysplast syndrom mds clonal diseas hematopoiet cell character hematopoiet cell hematopoiesi high risk transform acut myeloid leukemia aml although under mechan unclear mds often associ immun system disord especi cellular immun abnorm analyz number lymphocyt subset flow cytometri assay explor alter lymphocyt subset mds

D007694;D015470;D059630;D009190

T191;T025;T046

36,303,183

perform onstructur antigen rapid test detect four denv serotyp clinic specimen bangkok thailand dengu arbovir diseas larg effect public health subtrop tropic countri rapid accur detect dengu infect necessari diagnosi diseas manag previous develop high sensit immunochromatograph devic tkk st tkk nd kit base dengu virus denv nonstructur protein detect howev tkk kit evalu main use denv type clinic specimen collect bangladesh valid use clinic specimen serotyp need

D003716;D003715;D000071244;D000071243

T005;T047

36,303,182

inpati care provid perspect develop implement addict medicin consult servic small urban set evalu provid perspect develop implement inpati addict medicin consult servic includ awar servic perceiv role continuum care chang time percept care qualiti inpati substanc use disord

D000073316

T091

36,303,181

attitud toward human milk bank among nativ turkish refuge women resid rural region turkey mix method approach human milk bank hmb play essenti role provid human milk infant would otherwis abl receiv mother milk current donor milk bank turkey new health intervent success determin accept vital first step studi intend determin opinion knowledg attitud nativ turkish refuge women live etep aydn rural area turkey hmb

D017784;D012036

T098;T093

36,303,180

prr promot exosom secret vegf tgf via recruit ddxx stabil raba mrna hepatocellular carcinoma exosom deem import tool intercellular communic cancer cell studi investig role prr long non code rna antisens rna prr regul exosom secret hepatocellular carcinoma hcc cell

D006528;D008113;D055354;D062085;D035683

T026;T123;T191;T114

36,303,179

incid oxygen desatur use high flow nasal cannula versus facemask flexibl bronchoscopi patient risk hypoxemia randomis control trial patient obstruct sleep apnoea osa male sex obes older age hypertens prone hypoxemia flexibl bronchoscopi studi investig whether use high flow nasal cannula hfnc could reduc incid oxygen desatur bronchoscopi deep sedat patient risk hypoxemia

D000072601;D063087

T061;T074

36,303,178

sleepless inequ find behavior risk factor surveil system cross section studi despit larg bodi research advers effect incom inequ date studi examin impact sleep object investig examin associ us state incom inequ odd regular obtain inadequ h inadequ h sleep last h

D012892;D007182

T078;T033;T081;T047;T046

36,303,177

electroconvuls therapi combin lithium develop revers pure anom aphasia case report electroconvuls therapi ect combin mood stabil effect method treatment manic episod howev controversi view side effect

D004565;D001714

T061;T048

36,303,176

determin choic usual sourc care among older peopl cardiovascular diseas china evid studi global age adult health cardiovascular diseas cvd emerg lead contributor death global usual sourc care usc proven generat signific benefit elder cvd understand choic usc would generat import knowledg guid ongo primari care base integr health system build china studi aim analyz individu level determin usc choic among chines elder cvd generat two exemplari patient profil one like choos public hospit usc one like choos public primari care facil usc

D002318

T047

36,303,175

promot health social equiti famili navig prevent earli intervent servic proof concept studi health social inequ associ multipl advers childhood experi includ poverti mental ill child maltreat effect intervent current exist mani health social problem larg segment popul experi barrier access need servic align broader public health effort reduc health social inequ one state usa current studi describ develop format evalu brief low cost portabl model prevent orient famili servic navig call navig way

D005006;D008913

T098;T102

36,303,174

gene clone molecular character thermost chitosanas bacillus cereus ty import conceptu advanc health environ recogn enzym play key role green process industri particular interest chitosanas benefici recycl chitosan resourc produc chitosan oligosaccharid also chitosan gene express molecular character promot understand biolog function bacteri chitosanas well explor chitosanas util chitosan resourc

D001409;D048271

T121;T007;T109

36,303,173

explain experi health care provid regard organiz factor affect health educ qualit studi health educ consid import compon primari health care pay attent organiz factor help improv qualiti health educ therefor present studi conduct explain organiz factor affect health educ among health care provid

D006282;D006761

T093;T073;T097

36,303,172

futur public health emerg disast sustain insight support program healthcar provid mental health healthcar worker hcws forefront throughout covid pandem workplac base support program develop hospit global systemat collect data critic success inform program experi mental healthcar provid mhp support colleagu limit object studi explor experi mhp care hcw colleagu within novel workplac base mental health support program covid pandem provid insight facilit area improv barrier program sustain

D000086382;D004190

T047;T067

36,303,171

lycium barbarum polysaccharid improv dopamin metabol symptom mptp induc model parkinson diseas parkinson diseas pd second common neurodegen diseas middl age elder popul wherea cure pd far novel anim model medic await develop elucid aetiolog pd attenu symptom respect

D010302;D004365

T123;T047;T121

36,303,170

share care call new era rare diseas research develop scientif advanc understand genet mechan mani rare diseas previous unknown etiolog inspir optim patient clinic research communiti hope diseas specif treatment way howev rare diseas communiti reach critic point increas fragment structur oper model threaten abil har full potenti advanc genom comput technolog chang therefor need overcom issu plagu mani rare diseas also support econom viabl therapi develop data silo undermin drug develop fail rare diseas patient orphanet journal rare diseas apr outlin mani broad issu underpin increas fragment silo natur rare diseas space well issu encount communiti repres biomed research general propos sever initi key stakehold includ regul privat public foundat research institut reorient rare diseas ecosystem incent way believ would cultiv acceler innov specif propos support non proprietari patient registri greater data standard global regulatori harmon new busi model encourag data share research collabor default mode leadership need integr across sector drive meaning chang patient industri sponsor academ medic center transform research develop landscap unlock vast healthcar econom scientif potenti rare diseas patient new model ultim goal

D035583;D035843

T062;T047

36,303,169

assess trial repres use serious advers event observ analysi use aggreg individu level data clinic trial routin healthcar data applic randomis control trial pharmacolog agent older peopl frailtymultimorbid often uncertain due concern trial repres howev assess trial repres challeng complex explor approach assess trial repres compar rate trial serious advers event sae rate hospitalisationdeath routin care

D000073496

T033;T184;T046

36,303,168

smartphon rcct onlin repositori random control clinic trial smartphon applic chronic condit chronic health condit big impact disabl morbid mortal worldwid smartphon health applic app improv health patient chronic condit enhanc qualiti effici healthcar number random control trial rcts smartphon health app increas collect avail evid singl databas still miss purpos studi describ smartphon rcct progress databas rcts smartphon app chronic condit

D002908;D063731;D016032

T062;T047;T170

36,303,167

ergonom individu risk factor musculoskelet pain age workforc present studi aim investig possibl associ specif ergonom individu risk factor musculoskelet pain msp back shoulder hip knee region worker age

D059352;D009784;D009140

T033;T047

36,303,166

residenti proxim cropland birth childhood leukaemia domest parent occup pesticid exposur suspect involv occurr childhood acut leukaemia al role exposur agricultur activ littl known previous ecolog studi conduct franc observ increas acut lymphoblast leukaemia incid rate increas viticultur densiti municip resid diagnosi

D010575;D015470;D054198

T131;T191

36,303,165

malaria pregnanc control pregnanc outcom decad overview use ghana dhim ii data malaria pregnanc control intervent implement antenat care servic decad ghana uptak intervent seen steadi improv year occur within context decreas global trend malaria infect confirm decreas malaria pregnanc preval ghana howev much known improv intervent uptak reduct malaria infect preval impact pregnanc outcom countri studi aim describ trend matern anaemia low birth weight preval uptak malaria pregnanc control intervent last decad use data ghana district health inform manag system dhim ii

D000740;D000962;D008288;D015597

T121;T047

36,303,164

enrich prevotella intermedia human colorect cancer addit effect fusobacterium nucleatum malign transform colorect adenoma owe heterogen microbiota among individu popul fusobacterium nucleatum bacteroid fragili report enrich colorect cancer crc multipl studi thus discoveri addit bacteria contribut crc develop various popul expect aim identifi bacteria associ progress colorect adenoma carcinoma determin contribut bacteria malign transform patient han chines origin

D000236;D015179;D000230;D018256

T191

36,303,163

narrat review moder effect repercuss exercis intervent osteoporosi ingeni involv gut microbiota metabolit osteoporosi op system bone diseas character decreas bone mass destruct bone microstructur tend result enhanc bone fragil relat fractur well high disabl rate mortal exercis one common reliabl cost effect intervent prevent treatment op current numer studi reveal close associ gut microbiota gm bone metabol recent moreov exercis alter structur composit abund gm influenc bodi health via gm metabolit chang gm also depend choic exercis mode herein combin relev studi base insepar relationship exercis intervent gm op review aim discuss moder effect potenti mechan exercis intervent gm bone metabol well interact

D000069196;D010024

T047;T007;T001

36,303,162

transcriptom base network analysi relat like tumor associ macrophag infiltr identifi var potenti target improv melanoma immunotherapi efficaci like tumor associ macrophag tam independ prognost factor melanoma

D000084582;D008545

T191;T025

36,303,160

observ studi effect smoke cessat earlier clinic characterist cours acut exacerb chronic obstruct pulmonari diseas previous studi focus negat effect continu smoke chronic obstruct pulmonari diseas copd howev studi investig posit effect long term smoke cessat patient suffer acut exacerb copd

D016540;D029424

T055;T047

36,303,159

adher opioid agonist therapi predict uptak direct act antivir peopl use drug result french nation healthcar databas anr fantasio studi opioid agonist therapi oat associ reduc inject reduc hcv transmiss opportun initi hepat c virus hcv treatment peopl use drug pwud aim studi extent adher oat predict increas uptak direct act antivir daa pwud chronic hcv infect

D019698;D006526

T047

36,303,158

ttcc potenti target treatment lung cancer novel ttc gene tetratricopeptid repeat domain c ttcc main mediat interact protein involv progress various tumor studi determin effect ttcc lung adenocarcinoma found might use potenti intervent target

D008175;D000077192

T191

36,303,157

novel aquaporin associ optic neuriti rat model sever patholog function manifest optic neuriti common manifest aquaporin aqp antibodi seroposit neuromyel optica nmo extent tissu damag frequent sever often lead loss visual function curat treatment condit develop novel therapeut strategi elucid under patholog mechan use clinic relev experiment model necessari howev previous anim model result mild lesion limit function impair present studi attempt establish feasibl model sever patholog function manifest use high affin anti aqp antibodi subsequ aim address whether model suitabl potenti drug evalu test effect minocyclin well known microgliamacrophag inhibitor

D009902;D009471

T047

36,303,156

cognit enhanc supplement medic unit state resid physician use cognit enhanc medic supplement among healthi adult continu rise limit data exist use among resid physician given high competit stress lifestyl sought evalu preval motiv side effect use cognit enhanc supplement medic among resid physician larg unit state academ institut

D007396;D010820

T065;T097

36,303,155

role occup physician workplac covid pandem japan qualit interview studi coronavirus diseas covid pandem various impact busi worker worldwid spread infect report cluster outbreak workplac world health organ emphas workplac infect control measur occup physician op expect activ support employ effort minim damag pandem howev littl research role specialist pandem clarif contribut op health safeti workplac covid pandem would benefici ensur op effect deploy next pandem

D000086382;D016272;D010820

T078;T091;T067;T097;T047

36,303,154

genet mechan under increas microalg thermotoler maxim growth rate yield light follow adapt laboratori evolut adapt laboratori evolut ale power method strain optim toward abiot stress factor identifi adapt mechan studi green microalga picochlorum sp bpe cultur supra optim temperatur forc genet adapt robust adapt capac picochlorum strain turn emerg model evolutionari studi abiot stressor temperatur salin light

D058086;D000071436;D000460

T039;T002;T204

36,303,153

heterogen pragmat randomis trial sourc manag pragmat trial aim generat evid direct inform patient caregiv health system manag polici decis heterogen patient characterist contribut heterogen respons intervent howev mani sourc heterogen outcom base expertis judgement author identifi differ sourc clinic methodolog heterogen translat heterogen patient respons consid desir undesir discuss use real world trial exampl illustr heterogen manag whole cours trial

D064792;D016032;D012107

T062;T170;T096;T081;T169

36,303,152

parent cope uncertainti along sever combin immunodefici journey sever combin immunodefici scid group rare genet disord caus disrupt immun system function parent children scid experi mani uncertainti relat child diagnosi treatment recoveri qualiti life fulli understand parent experi throughout scid journey import explor stressor generat uncertainti parent cope stressor

D011788;D016511

T078;T047

36,303,151

preval pattern migrat intent doctor undergo train programm public tertiari hospit ekiti state nigeria emigr nigerian doctor includ undergo train develop countri europ america reach alarm rate

D033182;D007396

T065;T097;T041

36,303,150

adeno associ virus base caveolin deliveri via differ rout prevent cholesterol gallston format hepat caveolin cav reduc cholesterol gallston diseas cgd mice cav defici prone develop cgd howev remain unknown whether restor hepat cav express prevent develop cgd

D051242;D042882

T123;T116;T031;T192

36,303,149

clinic featur outcom congenit chylothorax singl tertiari medic center experi china congenit chylothorax cc uncommon congenit diseas object studi analyz clinic featur treatment outcom infant cc chines tertiari medic center

D002916;D010996

T047

36,303,148

associ overal dietari qualiti constip american adult cross section studi constip serious affect peopl life qualiti dietari adjust one effect method overal dietari qualiti report associ diseas associ constip report studi aim explor associ overal dietari qualiti constip

D004032;D014675

T168

36,303,147

climat driven mosquito born viral suitabl index measur risk transmiss dengu chikungunya zika mexico climat variabl influenc popul dynam aed aegypti mosquito transmit virus caus dengu chikungunya zika recent year diseas grown consider dengu fastest grow mosquito transmit diseas worldwid put per cent global popul risk effect antivir treatment vaccin wide avail control mosquito popul remain one effect way prevent epidem paper analys tempor spatial dynam dengu mexico chikungunya zika sinc first appear countri respect studi aim evalu season climatolog variabl affect potenti risk transmiss mosquito born diseas mexico among world endem countri term dengu given high incid mosquito born diseas size wide rang climat good case studi

D065632;D003715;D002646;D003716;D000071244;D000071243;D000330;D005416

T047;T005;T204

36,303,146

crosstalk circadian clock plant rhizomicrobiom circadian clock occur across kingdom life includ fungi bacteria present root associ soil known rhizospher recent work ami newman colleagu publish bmc biolog discov circadian clock arabidopsi plant affect rhythmic rhizospher microbi communiti bring play excit question whether bidirect rhythmic interact plant rhizomicrobiom discuss find newman et al suggest soil microbiom self sustain plant impos rhythmic challeng plant microbiom circadian clock research

D057906;D064307;D017360

T032;T040;T002;T028;T001

36,303,145

effect fix orthodont applianc gingiv status oral microbiota pilot studi pilot studi aim investig fix orthodont applianc simultan appli upper lower arch affect oral environ medium term

D003773;D064307

T001;T047;T032;T028

36,303,144

dnmta rh mutat drive daunorubicin resist acut myeloid leukemia via regul nrfnqo pathway dna methyltransferas dnmta often mutat arginin dnmta r acut myeloid leukemia aml aml patient dnmta r mutat usual resist daunorubicin treatment howev associ mechan still unclear therefor urgent investig daunorubicin resist aml patient dnmta r mutant

D004248;D015470;D016660;D051267

T123;T191;T126;T116

36,303,143

qualiti life among cervic cancer patient follow complet chemoradiotherapi ocean road cancer institut orci tanzania effect cancer treatment involv aggress chemo radiotherapi protocol alter survivor qualiti life qol recent arous attent focus clinic care rather holist client center look beyond morbid mortal studi assess qol associ factor among patient cervic cancer cc complet chemoradiotherapi

D011788;D002583

T078;T191

36,303,142

effect accept evid synthesi summari format clinic guidelin develop group mix method systemat review clinic guidelin develop often involv rigor synthesi evid involv multidisciplinari stakehold differ prioriti knowledg evid synthesi make communic find complex summari format typic use communic result evid synthes howev littl consensus format effect accept differ stakehold

D036301

T062

36,303,141

role area level social depriv childhood adolesc consult rate primari care popul base cohort studi studi show children adolesc social depriv area sda consult general practition gp often least social depriv area non sda given gps see wide rang diseas import know clinic diagnos shape socioeconom factor primari object determin associ area level social depriv consult rate pediatr popul secondari object explor associ across wide rang clinic diagnos

D000091489;D012017

T170;T097;T081;T068;T058

36,303,139

cultur adapt guidelin offer mental health first aid person potenti traumat event delphi expert consensus studi brazil traumat event increas risk mental disord countri relat develop mental health support system servic assist peopl experienc potenti traumat event may unavail situat peopl communiti becom key sourc support howev alway knowledg skill offer effect help studi report cultur adapt brazil english languag mental health first aid guidelin help someon experienc potenti traumat event

D005392;D008603

T061;T041