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biomedical-topic-categorization-validation

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36.4M
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36,303,137
feasibl dri blood spot hepat c diagnosi vulner subject peopl live remot area brazil agil access cheap diagnosi hepat c virus hcv infect essenti achiev elimin infect worldwid mandat world health organz part strategi dri blood spot dbs attract altern sampl collect among peopl live remot area vulner popul due less invas collect biosafeti storag transport sampl room temperatur
D016174;D006526
T005;T047
36,303,136
patient report outcom follow cement versus cementless primari total knee arthroplasti compar analysi base propens score match exist studi patient report outcom pro follow total knee arthroplasti tka base fixat method cement vs cementless limit singl center small sampl size use multicent data compar baselin earli post oper global condit specif pros patient undergo cement versus cementless tka
D019645
T061
36,303,135
effect predict hiv proteas cleavag site use ensembl learn approach site inform substrat cleav human immunodefici virus proteas hiv prs great signific design effect inhibitor hiv virus varieti machin learn base algorithm develop predict hiv pr cleavag site extract relev featur substrat sequenc howev reli sequenc inform suffici ensur promis perform due uncertainti way separ dataset use train test moreov exist noisi data ie fals posit fals negat cleavag site could negat influenc accuraci perform
D016333;D015497
T005;T126;T116
36,303,134
toward prevent exfoli glaucoma target remov fibrillar aggreg associ exfoli syndrom exfoli syndrom present accumul insolubl fibrillar aggreg common correl age caus ocular complic notabl open angl glaucoma despit advanc understand pathogenesi risk factor associ exfoli syndrom signific progress curat pharmacotherapi diseas thought abil target fibrillar aggreg associ exfoli may offer new therapeut approach facilit direct remov affect tissu phage display techniqu yield two peptid lpsynlhphvpp ipllnpgsmql could differenti exfoli non affect region human len capsul peptid conjug magnet particl use click chemistri investig abil target remov exfoli materi anterior human len capsul behavior fibrillar materi upon bind magnet particl assess use magnet pin rotat magnet field various strength ex vivo studi show magnet particl peptid conjug could generat enough mechan forc remov larg aggreg exfoli materi len capsul expos low frequenc rotat magnet field g hz biocompat target peptid without conjug magnet particl confirm use mtt cell toxic assay livedead cell viabil assay dna fragment studi primari cultur human trabecular meshwork cell novel minim invas therapeut approach treatment exfoli glaucoma via target remov exfoli materi could appli tissu within anterior segment eye
D017889;D005902
T047
36,303,132
transcriptom mirnom data integr lymphoblastoid cell highlight key role immun relat function lithium treatment respons bipolar disord bipolar disord bd complex mental diseas character recurr episod mania depress lithium li repres mainstay bd pharmacotherapi despit narrow therapeut index high variabl treatment respons howev although sever studi conduct molecular mechan under li therapeut effect remain unclear
D001714;D035683
T123;T114;T048
36,303,131
incid factor relat nonmotor scooter injuri new york state new york citi studi provid analysi contemporari trend demograph patient treat injuri nonmotor scooter emerg depart new york state exclud new york citi nys new york citi nyc
D004636;D012111
T078;T073;T082;T083;T093;T033;T056;T096;T081
36,303,130
relationship energi balanc relat behavior person famili factor overweightobes primari school student age year china cross section studi increas rate childhood obes worldwid serious threat health school age children unhealthi behavior habit modifi factor control childhood obes person famili factor key influenc factor behavior habit school age children studi assess relationship overweightobes energi balanc relat behavior ebrb influenc factor school age children
D050177;D063766
T033;T047
36,303,129
condit wealth estim associ wealth mobil health human capit low middl incom countri cohort tempor harmon asset indic allow studi chang relat wealth mean varianc social mobil time associ adult health human capit cohort studi condit measur unexplain residu indic regress past valu use measur previous use studi relat import key life stage anthropometr growth identifi specif life stage chang relat wealth import adult health longitudin studi discuss assumpt strength limit methodolog appli relat wealth provid illustr exampl use public avail longitudin dataset show relat wealth chang differ life stage differenti associ bodi mass index adulthood
D007182
T078;T081
36,303,128
psychometr properti intern stigma mental ill ismi scale dutch sampl employe mental ill intern stigma numer negat effect well employ peopl mental ill brief valid reliabl measur need get better understand self stigmat aim studi translat brief version intern stigma mental ill ismi scale dutch version assess reliabl valid dutch version sampl employe mental ill
D057545;D001523
T033;T048
36,303,127
evalu factor affect triag decis make among emerg depart nurs emerg medic technician iran studi base benner theori emerg depart ed nurs emerg medic technician emt find perform triag time pressur limit inform identifi effect triag decis make process play signific role promot patient safeti expert abl make faster effect decis emerg novic
D004634;D016529
T091;T097
36,303,126
inhibit srpk key splice regul exhibit antitumor chemotherapeut sensit effect extranod nkt cell lymphoma cell increas evid convinc shown abnorm pre mrna splice implic develop human malign serinearginin rich protein kinas srpk key splice regul report overexpress leukemia cancer type suggest therapeut potenti target srpk
D054391
T191
36,303,125
predictor abnorm electroencephalogram neuroimag children present emerg depart new onset afebril seizur electroencephalogram neuroimag pediatr patient new onset afebril seizur perform detect under patholog sever condit may requir emerg neuro intervent guid prognosi studi aim determin predictor abnorm eeg neuroimag children present emerg depart new onset afebril seizur
D012640;D059906
T060;T184;T047;T046
36,303,124
pregnant woman thymoma associ pure red cell aplasia pure red cell aplasia prca hematolog disord character anemia sever reticulocytopenia caus mark reduct erythroid precursor bone marrow prca known associ pregnanc thymoma associ prca pregnanc rare success manag report
D013945;D013953;D012010
T047;T191
36,303,123
genom sequenc entomopathogen serratia entomophila isol characteris speci specif itacon degrad pathway isol serratia entomophila proteamaculan yersiniacea caus diseas specif endem new zealand pastur pest costelytra giveni coleoptera scarabaeida previous genom profil shown entomophila isol appear conserv genom present conserv plasmid absenc c giveni larva entomophila preval reduc soil time suggest entomophila form host specif relationship c giveni help defin potenti genet mechan drive retent chronic diseas entomophila genom isol sequenc enabl identif uniqu chromosom properti defin gainloss accessori virul factor relev pathogen c giveni larva
D012705;D001517
T007;T204
36,303,122
routin laboratori test hemodialysi frequent need hemodialysi patient follow routin laboratori test uncertainti whether test alway lead chang decis make studi aim discov number year interventionschang prescript base test depict group patient would benefit reduc increas laboratori blood test
D000740;D006397;D007676
T121;T047
36,303,121
health relat qualiti life patient undergo centr hemodialysi rwanda cross section studi studi assess qualiti life patient chronic end stage kidney diseas sub saharan africa aim describ health relat qualiti life hrqol patient undergo centr mainten hemodialysi rwanda use kdqol determin sociodemograph clinic factor associ qualiti life
D007676;D007674
T047
36,303,120
emerg medic care patient psychiatr disord challeng opportun result multicent survey pre clinic psychiatr emerg general treat emerg medic staff subsequ clinic treatment often condit interact problem emerg medic staff psychiatr clinic staff
D004632;D001523
T061;T058;T093;T048
36,303,119
prognost impact number metastat lymph node surgeri local advanc hypopharyng cancer postop chemoradiotherapi crt standard therapi patient high risk factor head neck squamous cell carcinoma includ posit margin extra nodal extens ene howev prognost impact number patholog metastat lymph node plns hypopharyng carcinoma hpc unclear thus studi aim investig postop prognost factor local advanc hypopharyng squamous cell carcinoma la hpscc focus number plns
D007012;D002294;D006258
T191
36,303,118
pyogen spondyl caus klebsiella pneumonia possibl hypervirul klebsiella pneumonia consid klebsiella pneumonia rare second common causat agent among gram negat bacteria caus pyogen spondyl howev avail studi serotyp virul factor clinic characterist associ k pneumonia caus pyogen spondyl accord investig clinic characterist pyogen spondyl k k serotyp virul factor k pneumonia
D007710;D013166
T047
36,303,117
play music instrument risk dementia among older adult systemat review meta analysi prospect cohort studi engag leisur activ suggest protect older adult dementia howev associ play music instrument risk dementia well establish studi aim investig associ older adult use systemat review meta analysi prospect cohort studi
D003704
T048
36,303,116
inhibit platelet activ suppress reactiv enter glia mitig intestin barrier dysfunct sepsi intestin barrier dysfunct associ reactiv enter glia cell egc result earli sepsi also caus multipl organ dysfunct syndrom inhibit platelet activ propos potenti treatment septic patient efficaci amelior organ damag barrier dysfunct platelet activ cdl transloc granul platelet surfac serv biomark platelet activ reliabl predictor sepsi prognosi given circul cdl origin activ platelet present studi aim investig inhibit platelet activ mitig intestin barrier dysfunct associ suppress reactiv egc under mechan
D023201;D018805
T129;T047;T046;T116
36,303,115
caregiv perspect central nervous system infect ill trajectori among older person dementia northern uganda qualit communiti base studi studi explor central nervous system cns infect ill trajectori among older person dementia sub saharan african ssa set studi explor caregiv perspect central nervous system infect ill trajectori among older person dementia northern uganda
D003704;D006973;D002494;D020773
T047;T048
36,303,114
synthet doubl invers recoveri imag brain mri quantit evalu feasibl synthet mri comparison convent doubl invers recoveri fluid attenu invers recoveri sequenc synthet mr imag symri allow reconstruct various contrast imag includ doubl invers recoveri dir singl scan studi aim investig advantag symri compar synthet dir imag synthet weight fluid attenu invers recoveri tw flair convent dir imag
D008279;D066127
T024;T060;T059;T170;T023
36,303,113
vascufit vascular effect non linear period exercis train sedentari adult elev cardiovascular risk protocol random control trial earli vascular age eva increas preval general popul exercis import primari cardiovascular prevent often insuffici due ineffect train method lack biomark suitabl monitor vascular effect vascufit assess effect non linear period aerob exercis nlpe non athlet sedentari popul improv establish promis biomark eva
D002318;D066026
T047;T025
36,303,112
transcriptom stabil labil explain sensit climat stressor corallin alga crustos corallin alga cca calcifi red macroalga play import ecolog role includ stabilis reef framework provis settlement cue rang marin invertebr previous research respons cca ocean warm ow ocean acidif oa found magnitud effect speci specif respons ow oa could link diverg under molecular process across speci
D000461;D037421
T204;T002
36,303,111
characterist outcom covid patient b omicron domin compar b delta german hospit sar cov variant b omicron first describ novemb becam domin variant worldwid exist data suggest reduc diseas sever omicron infect comparison b delta differ characterist hospit outcom covid patient germani omicron period compar delta thorough studi icd code base sever acut respiratori infect sari surveil repres integr part infecti diseas control germani
D000086402;D000086382
T005;T067;T047
36,303,110
surfac layer protein hypervirul clostridioid difficil ribotyp induc signific chang gene express tight junction inflammatori respons human intestin epitheli cell surfac layer protein slpa primari outermost structur clostridioid difficil play essenti role c difficil pathogenesi although interact host intestin cell yet understood aim studi investig effect slpa extract c difficil tight junction tj protein express induct pro inflammatori cytokin human colon carcinoma cell line ht slpa extract three toxigen c difficil clinic strain includ rt rt rt well c difficil atcc non toxigen strain cell viabil perform mtt assay mrna express tj protein inflamm associ gene determin use quantit rt pcr addit secret il il tnf cytokin measur elisa
D016360;D003015
T047;T007;T037
36,303,109
acetaminophen chang rna level relat protein express il treat chondrocyt cell acetaminophen common recommend earli analgesia osteoarthr howev molecular mechan act remain unknown aim studi investig effect acetaminophen inflamm extracellular matrix degrad human chondrocyt possibl molecular mechan involv effect
D000082;D019902;D053583
T129;T121;T116;T025;T109
36,303,108
use region citrat anticoagul medium cut membran pilot report region citrat anticoagul hemodialysi provid immedi complet anticoagul effect limit extracorpor circuit citrat becom standard anticoagul acut renal replac therapi wide use various intermitt hemodialysi modal especi patient contraind heparin increas adopt medium cut membran experi region citrat anticoagul need knowledg first report assess feasibl region citrat anticoagul expand hemodialysi
D002118;D019343
T123;T196;T121;T109
36,303,107
altruist elder valuabl unrecognis kidney donor group case report year old unspecifi kidney donor kidney transplant definit treatment end stage renal diseas esrd offer improv qualiti life surviv benefit remain dialysi howev prevail signific mismatch patient await transplant avail donor kidney time initi stringent donor criteria broaden organ extend criteria donor ecd older donor accept transplant spectrum live donor also undergon chang close famili member increas non relat non direct altruist donor newli classifi unspecifi donor unspecifi elder donor could potenti untap resourc expand kidney donor pool global
D016030;D009927
T061;T073;T055;T033;T058
36,303,106
dietari acid load altern healthi eat index score bacteri vaginosi associ case control studi chang dietari pattern may altern treatment bacteri vaginosi preval vagin infect women
D000072001;D016585
T061;T055;T033;T047
36,303,105
mcm human cancer function mechan clinic signific aberr dna replic main sourc genom instabl lead tumorigenesi progress mcm core subunit eukaryot helicas play vital role dna replic dysfunct mcm result occurr progress multipl cancer impair dna replic cell prolifer
D004261;D009369
T045;T191
36,303,104
communiti acquir pneumonia use chest x ray diagnosi famili practic accord guidelin diagnosi pneumonia confirm chest x ray ensur appropri manag wise use antibiot studi aim describ use x ray famili doctor patient follow diagnosi pneumonia primari care practic north israel
D011014;D017714
T047;T050
36,303,103
par plana vitrectomi subretin tissu plasminogen activ larg exud submacular hemorrhag case seri evalu anatom function outcom patient larg submacular hemorrhag smh treat par plana vitrectomi ppv combin subretin tissu plasminogen activ tpa inject intraocular gas tamponad addit post oper intervent
D012166;D010959;D014821
T061;T121;T116;T126;T047
36,300,035
long term health sever acut malnutrit children adult role pancrea sampa protocol background prenat growth retard may increas risk later chronic non communic diseas ncds includ diabet howev long term effect wast malnutrit childhood adulthood less studi pancreat exocrin endocrin function critic nutrit ncd aetiolog may fulli recov follow malnutrit howev evid mechanist inform piecem hypothesis wast malnutrit age long term detriment effect endocrin exocrin pancreat structur function method sampa intern research programm assess pancreat structur function particip ongo observ nutrit cohort two adolesc four adult zambia tanzania philippin india pancrea size structur calcif assess ultrasound comput tomographi ct scan exocrin function faecal elastas serum lipas endocrin function haemoglobin ac hbac blood glucos insulin c peptid concentr oral glucos toler test ogtt depth hormon analys incretin glucagon proinsulin trypsinogen ogtt intraven glucos toler test done subset adult particip pancreat size function outcom compar peopl without prior wast malnutrit analys investig effect modif sex current age time sinc malnutrit current bodi mass index dietari pattern mathemat model ogtt data use estim relat contribut glucos dysregul decreas insulin product chang insulin clearanc increas insulin resist proinsulininsulin ratio analys archiv sampl tanzanian cohort use nest case control design investig whether abnorm valu preced diabet conclus sampa larg scale multi centr research programm use data peopl without prior wast malnutrit assess sever aspect pancreat phenotyp provid coher evid futur polici programm malnutrit diabet
D003920;D000067011;D044342
T047
36,303,071
age relat huntington diseas progress model direct reprogram patient deriv striatal neuron highlight impair autophagi huntington diseas hd inherit neurodegen disord adult onset clinic symptom mechan age drive onset neurodegener patient hd remain unclear studi examin striatal medium spini neuron msns direct reprogram fibroblast patient hd model age depend onset patholog found pronounc neuron death occur select reprogram msns symptomat patient hd hd msns compar msns deriv younger pre symptomat patient pre hd msns control msns age match healthi individu observ age associ alter chromatin access hd msns pre hd msns identifi mir b p whose age associ upregul promot hd msn degener impair autophag function human specif target stat untransl region reduc mir b p chemic promot autophagi increas resili hd msns neurodegener result demonstr mirna upregul age hd detriment process drive msn degener potenti approach enhanc autophagi resili hd msns
D006816;D035683
T123;T047;T114
36,303,070
map neurotransmitt system structur function organ human neocortex neurotransmitt receptor support propag signal human brain receptor system situat within macro scale neuroanatomi shape emerg function remain poor understood exist comprehens atlas receptor collat positron emiss tomographi data healthi individu construct whole brain three dimension normat atlas receptor transport across nine differ neurotransmitt system found receptor profil align structur connect mediat function includ neurophysiolog oscillatori dynam rest state hemodynam function connect use neurosynth cognit atlas uncov topograph gradient overlap receptor distribut separ extrins intrins psycholog process final found expect novel associ receptor distribut cortic abnorm pattern across disord replic find independ collect autoradiographi dataset work demonstr chemoarchitectur shape brain structur function provid new direct studi multi scale brain organ
D001931;D019579
T062;T060;T024;T023
36,303,069
crispri screen human ipsc deriv astrocyt elucid regul distinct inflammatori reactiv state astrocyt becom reactiv respons insult central nervous system adopt context specif cellular signatur output systemat understand under molecular mechan lack studi develop crispr interfer screen human induc pluripot stem cell deriv astrocyt coupl singl cell transcriptom systemat interrog cytokin induc inflammatori astrocyt reactiv found autocrin paracrin il interferon signal downstream canon nf b activ drove two distinct inflammatori reactiv signatur one promot stat inhibit stat signatur overlap observ experiment context includ mous model marker upregul human brain alzheim diseas hypox ischem encephalopathi furthermor valid marker signatur regul stat vivo use mous model neuroinflamm result platform establish potenti guid develop therapeut select modul differ aspect inflammatori astrocyt reactiv
D057026;D000544
T047;T025;T048
36,303,068
development atlas somatosensori diversif matur dorsal root ganglia singl cell mass cytometri precis control develop somatosensori system essenti detect pain itch temperatur mechan touch bodi posit investig protein level chang occur somatosensori develop perform singl cell mass cytometri dorsal root ganglia cbl mice sex litter replic collect daili embryon day postnat day measur near million cell quantifi molecular distinct somatosensori glial distinct neuron state across timepoint analysi differenti trajectori reveal rare cell co express two trk receptor express stem cell marker suggest neurotroph factor receptor play role cell fate specif comparison previous rna base studi identifi substanti differ mani protein mrna pair demonstr import protein level measur identifi function cell state overal studi demonstr mass cytometri high throughput scalabl platform rapid phenotyp somatosensori tissu
D005727;D009474
T023;T025
36,303,059
plasma tigit level possibl marker hiv relat liver damag cell immunoglobulin itim domain tigit key role immunopathogenesi hiv previous studi immun checkpoint receptor main focus membran form evalu clinic signific solubl form tigit stigit peopl live hiv blood sampl untreat hiv infect patient healthi individu collect tigit concentr plasma measur elisa method decreas level plasma tigit hiv infect patient found negat associ astalt ratio r p indic liver damag moreov proport tigit cd cd cell hiv infect individu increas compar healthi control p indic chang plasma tigit level least partial attribut cd cd cell furthermor strong posit correl tigit plasma level lymphocyt activ gene lag plasma level hiv infect patient linear correl coeffici r therefor plasma tigit level possibl marker hiv relat liver damag lag close relat tigit possibl play co ordin role hiv relat liver damag
D011971;D015658
T129;T047;T116;T192
36,303,058
synthesi anti influenza activ vinylphosphon acid co polym new copolym vinylphosphon acid vpa deoxi methacrylamido glucos acryloylmorpholin acrylamid synthes antivir activ influenza virus studi vitro vivo experi optim antivir characterist low cytotox exhibit copolym vpa composit mol molecular weight polym exhibit virus inhibit properti ic gml select index prophylact intranas administr polym murin model influenza pneumonia complet prevent virus induc death anim wherea level mortal placebo group result studi indic high antivir potenti polymer compound base vpa
D011108;D063065
T104;T122;T131;T109
36,303,057
evalu instrument method classif beluga delphinapterus leuca behavior base paramet acceler noninvas instrument method classif behavior beluga whale delphinapterus leuca base paramet movement evalu motor activ character mean standard deviat beluga tail fluke acceler found use decis tree algorithm least two type beluga behavior distinguish rest surfac activ swim pool determin accuraci depend paramet averag rest surfac activ swim behavior differ accuraci classif rest surfac base three axi overal bodi acceler minim futur accuraci may improv use acceler paramet shorten interv analysi optim classif algorithm
D050643
T015
36,303,056
deliveri antibodi like molecul monobodi capabl bind sar cov virus nucleocapsid protein target cell base previous studi two antibodi like molecul monobodi capabl high affin interact sar cov nucleocapsid protein dissoci constant ten nm select deliveri target cell genet engin construct contain monobodi tat peptid place either n c terminus result polypeptid produc express e coli construct highest affin sar cov nucleocapsid protein reveal use thermophoresi techniqu cellular thermal shift assay demonstr abil construct interact nucleocapsid protein within hekt cell transfect sar cov nucleocapsid protein fuse mrubi fluoresc protein replac tat peptid shuttl peptid contain endosomolyt peptid signific improv penetr construct target cell
D000086402;D000086382
T005;T067;T047
36,303,055
increas effici cytochrom p electrocatalysi use electrod modif spatial order anod aluminum oxid base nanostructur investig metabol transform drug new approach modifi electrod use porous membran base anod aluminum oxid pore diamet membran like substanc didodecyldimethylammonium bromid ddab propos studi electrocatalyt effici system approach make possibl increas catalyt effici cytochrom p depend n demethyl erythromycin use membran pore diamet use membran pore size electrod modif use porous membran shift potenti electrochem reduct catalysi cytochrom p posit direct v indic thermodynam favor process electron transfer enzymat electrocatalysi
D000537;D049329
T121;T197;T073
36,303,054
recruit chromatin ga n associ factor gaf psq transgen model system depend presenc architectur protein bind site polycomb group pcg repressor trithorax group trxg activ transcript essenti proper develop mainten gene express profil multicellular organ drosophila pcgtrxg protein interact dna element call pre polycomb respons element previous shown repress activ inact pre transgen induc architectur protein bind site shown induct repress associ recruit pcgtrxg protein includ dna bind factor pho combgap present studi test associ two pre dna bind factor gaf psq bxdpre presenc absenc site architectur protein result shown factor effici recruit bxdpre presenc adjac bind site architectur protein su hw ctcf pita
D002843;D029721
T123;T116
36,303,053
induct hypox respons caco cell promot express gene involv sar cov endocytosi transcytosi present manuscript analyz influenc hypox respons caco cell express gene mirna involv mechan intracellular transport sar cov viral particl especi endocytosi transcytosi use rna sequenc caco cell treat hypoxia induc oxyquinolin deriv show two fold increas express main sar cov receptor ace express non canon receptor tfrc also elev also observ signific increas express level gene low densiti lipoprotein ldl receptor famili play crucial role transcytosi ldlr lrp lrp lrp upregul ldlr coupl downregul hsa mir p direct bind ldlr mrna thus hypox respons caco cell includ upregul gene involv mechan endocytosi transcytosi sar cov viral particl
D000086382;D004705;D057900;D015687
T047;T067;T043
36,303,052
geldanamycin enhanc radioprotect effect peroxyredoxin irradi fibroblast aim studi evalu possibl increas radioprotect potenti peroxiredoxin prdx mutant form sa combin use geldanamycin ga fibroblast irradi x ray dose gy mutant enzym sa phospholipas activ exhibit pronounc radioprotect activ combin ga use combin radioprotect drug complet abolish peak nf b activ irradi cell anoth transcript factor p indic level cell apoptosi increas upon irradi also reduc sa combin ga low molecular weight protein p marker cell senesc whose product increas upon irradi also normal sa use combin ga addit use combin radioprotect drug signific reduc stress respons cell x ray irradi
D011837
T121;T039
36,303,051
transcript factor glrs famili involv cytokinin depend regul plastid rna polymeras sca gene express deetiol arabidopsi thaliana light depend transcript factor glks arabidopsi thaliana involv anterograd regul chloroplast biogenesi deetiol regul express photosynthet nuclear encod gene also mediat transcript plastid gene chloroplast biogenesi determin time light endogen factor phytohormon among cytokinin signific acceler format photosynthet activ chloroplast work shown tran factor glks function cytokinin depend regul mediat posit cytokinin effect plastom express activ transcript sca nuclear gene encod plastid rna polymeras rpotp
D017360;D029681
T116;T002
36,303,050
effect silicon nanoparticl activ antioxid enzym tomato root invad meloidogyn incognita kofoid et white chitwood effect silicon nanoparticl gml activ lipid peroxid peroxidas superoxid dismutas catalas tomato root invad root knot nematod meloidogyn incognita studi shown earli stage parasit plant treat si nps low activ po sod well increas level lipid peroxid observ indic format free radic reactiv oxygen speci ros inhibit nematod limit format giant cell sedentari stage stage nutrit develop egg product root treat plant show increas activ po cat sod well low activ lpo compar infest untreat plant make possibl maintain balanc format neutral ros import protect plant tissu oxid process also preserv giant cell feed parasit present data first time show mechan action si nps develop resist adapt plant biogen stress associ effect various compon antioxid system function interact
D014431;D018551;D053758
T168;T002;T073;T204
36,303,049
effect xylazinezoletil anesthesia radiosensit mice total irradi x ray proton carbon ion effect xylazin zoletyl anesthesia radiosensit mice irradi proton carbon ion two region bragg curv x ray radiat studi accord criteria day surviv dynam death averag life span dead mice maximum effect anesthesia time observ decreas death anim irradi carbon ion bragg peak case irradi peak effect time case proton irradi bragg peak protect effect anesthesia factor observ dose gy mice irradi x ray dose rang gy anesthesia effect coeffici accord day surviv method shown use xylazin zoletil mixtur signific chang radiosensit mice depend radiat dose radiat sourc qualiti
D000758;D004307;D011836;D014991
T061;T121;T032;T109;T081
36,303,048
tag mts complex activ chemotaxi regulatori cell one basic featur immun system abil sustain balanc activ suppress effector lymphocyt process key role belong subpopul cell call regulatori cell treg mani cancer autoimmun diseas caus malfunct treg investig subpopul import develop new therapeut approach studi demonstr regulatori cell migrat along concentr gradient tag mts complex also produc agent induc blood cell migrat
D050378;D009369
T191;T025
36,303,047
particip nitric oxid realize hemostat effect glyprolin peptid involv nitric oxid respons hemostasi system appear prolin contain peptid blood studi experi rat shown singl intranas administr peptid pgp rpgp pgpl rat led increas fibrinolyt anticoagul antiplatelet potenti blood use non select synthas blocker l name almost complet inhibit anticoagul effect glyprolin found mechan anticoagul fibrinolyt antiplatelet action glyprolin peptid determin activ enzymat pathway nitric oxid format obtain result reveal involv nitric oxid implement hemostat vascular endotheli function organ
D009569;D006490
T121;T197
36,303,019
sensit genet encod sensor popul subcellular imag camp vivo cyclic adenosin monophosph camp signal integr inform divers g protein coupl receptor neuromodul receptor regul pivot biolog process cellular specif subcellular specif manner howev vivo cellular resolut imag camp dynam remain challeng screen exist genet encod camp sensor develop best perform deriv three improv variant call campfir compar parent sensor sensor exhibit fold increas sensit camp cytosol distribut campfir compat ratiometr fluoresc lifetim imag detect camp dynam elicit norepinephrin physiolog relev nanomolar concentr imag campfir awak mice reveal tonic level camp cortic neuron associ wake modul opioid differenti regul across subcellular compart furthermor enforc locomot elicit neuron specif bidirect camp dynam campfir also function drosophila overal campfir may broad applic studi intracellular signal vivo
D015374
T059;T075
36,303,017
neti infer evolut neoantigen cell interact tumor neoantigen key target antitumor immun respons cytotox cell play critic role affect tumor progress immunotherapi treatment respons howev littl known interact neoantigen cell ultim affect evolut cancer mass develop hierarch bayesian model name neoantigen cell interact estim neti infer histori neoantigen cd cell interact tumor neti systemat valid appli examin molecular pattern tumor compil panel cancer type show tumor increas immun select pressur time associ cell activ relat express signatur also identifi subset exhaust cytotox cell postimmunotherapi associ tumor clone newli aris treatment analys demonstr neti enabl interrog relationship individu neoantigen repertoir tumor molecular profil found cell inflamm gene express profil tigep predict patient outcom tumor increas immun pressur time reveal curious synergi cell neoantigen distribut overal provid new tool capabl reveal imprint left neoantigen tumor development process predict tumor progress pressur host immun system
D000951;D009369
T129;T191;T116
36,303,000
bridg landscap ecolog urban scienc respond rise threat mosquito born diseas preval diseas born mosquito particular genus aed rise worldwid attribut part dramat rate contemporari urban aed born diseas risk vari within citi investig use urban scienc base approach examin citi structur function contribut vector pathogen introduct mainten integr theori complex adapt system landscap ecolog urban geographi develop urban system framework understand aed born diseas framework establish citi compris hierarch structur patch differ land use characterist properti patch composit determin local diseas risk configur connect drive emerg pattern pathogen spread complex ad incorpor individu collect human social structur consid feedback among social actor landscap drive risk transmiss discuss concept appli case studi aed born diseas around world ultim framework strengthen exist theoret mix qualit quantit approach advanc consider intervent includ urban plan exampl pipe water provis emerg vector control strategi exampl wolbachia infect mosquito implement prevent control rise threat aed born diseas
D000330;D000079426
T047;T204
36,302,976
lacticaseibacillus rhamnosus probio extend lifespan caenorhabd elegan probiot character use maintain balanc host gut flora confer health effect studi focus potenti delay age host show lacticaseibacillus rhamnosus probio probio healthi breast milk probiot enhanc locomotor abil slow declin muscl function model organ caenorhabd elegan live probio signific extend lifespan c elegan dietari restrict independ manner screen various age relat mutant c elegan find probio extend lifespan via p cascad daf signal pathway independ daf depend skn probio protect repair damag mitochondria activ mitochondri unfold protein respons signific increas amino acid sphingolipid galactos fatti acid bacteri metabolit might involv extend lifespan c elegan reveal probio dietari supplement potenti delay age c elegan also provid new method insight analyz probiot improv host health delay occurr age relat chronic diseas
D017173;D029742
T116;T204
36,302,971
chaperon dnajb surveil fg nucleoporin requir interphas nuclear pore complex biogenesi biogenesi nuclear pore complex npcs includ format permeabl barrier compos phenylalanin glycin rich nucleoporin fg nup regul select passag biomolecul across nuclear envelop fg nup intrins disord prone liquid liquid phase separ aggreg isol fg nup protect make inappropri interact npc biogenesi fulli understood find dnajb molecular chaperon heat shock protein network form foci close proxim npcs number foci decreas upon remov protein involv earli step interphas npc biogenesi convers process stall last step number dnajb contain foci increas foci identifi herniat nuclear envelop immunoelectron tomographi show dnajb local insid lumen herniat aris npc biogenesi intermedi loss dnajb result accumul cytosol annul lamella structur contain part assembl npcs featur associ disturb npc biogenesi find dnajb bind fg nup prevent aggreg fg region sever fg nup cell vitro togeth data show molecular chaperon dnajb provid qualiti control npc biogenesi involv surveil nativ intrins disord fg nup
D028861;D022022
T026;T123;T116
36,302,970
atyp nuclear envelop condens link neurolog disord reveal nucleoporin direct chaperon activ dyt dystonia debilit neurolog movement disord aris mutat aaa atpas torsina hallmark torsin dysfunct nuclear envelop bleb result defect nuclear pore complex biogenesi whether bleb activ contribut diseas manifest unknown report fg nucleoporin bleb lumen form aberr condens contribut dyt dystonia provok two proteotox insult short live ubiquityl protein normal rapid degrad partit bleb lumen becom stabil addit bleb select sequest specif hsp hsp chaperon network modul bleb compon mlf mlf suppress ectop accumul fg nucleoporin modul select properti size condens vitro studi identifi dual mechan proteotox context condens format establish fg nucleoporin direct activ nuclear chaperon network
D009685;D004421
T026;T184
36,302,969
pten direct development metabol signal innat like cell fate tissu homeostasi phosphatas tensin homologu pten frequent mutat human cancer role lymphopoiesi tissu homeostasi remain poor defin show pten orchestr two step development process link antigen receptor il stat signal type innat like cell generat loss pten lead pronounc accumul matur il produc innat like cell thymus il essenti accumul ablat il il signal rectifi reduc surviv femal pten haploinsuffici mice model human patient pten mutat singl cell transcriptom network analys reveal dynam regul pten mtor metabol activ accompani type cell program furthermor delet mtorc mtorc block pten loss driven type cell accumul shape foxo stat pathway collect studi establish development metabol signal network underpin type cell fate decis function effect coordin pten depend tissu homeostasi
D020381;D013601
T129;T123;T116;T025;T192
36,302,967
elong stabil microtubul control central spindl asymmetri polar traffick cell fate determin asymmetr cell divis give rise two daughter cell inherit differ determin therebi acquir differ fate polar traffick endosom contain fate determin recent emerg evolutionarili conserv featur asymmetr cell divis enhanc robust asymmetr cell fate determin fli fish mammal particular polar sort signal endosom asymmetr central spindl contribut asymmetr cell divis drosophila melanogast howev central spindl asymmetri aris remain elus identifi moonlight function elong complex establish protein acetylas trna methylas involv fidel protein translat key factor central spindl asymmetri elong control spindl asymmetri stabil microtubul differenti anterior side central spindl accord lower activ elong anterior side use nanobodi mistarget endosom wrong cell molecular elong regul microtubul dynam independ acetyl methyl enzymat activ instead elong direct bind microtubul increas polymer speed decreas catastroph frequenc data establish non canon role elong core cytoskeleton polar asymmetr signal
D004331;D008941
T026;T204
36,302,962
human muscl inspir singl fibr actuat revers percol artifici muscl indispens compon next generat robot capabl mimick sophist movement live system howev optim combin actuat paramet includ strain stress energi densiti high mechan strength requir practic applic report mammalian skelet muscl inspir singl fibr bundl larg strong contract actuat use exfoli graphen filler within uniaxi liquid crystallin matrix enabl phototherm actuat larg work capac rapid respons moreov revers percol graphen filler induc thermodynam conform transit mesoscal structur situ monitor electr switch dynam percol behaviour effect strengthen mechan properti actuat fibr particular contract actuat state enabl mammalian muscl like reliabl revers actuat take advantag mechan compliant fibr structur smart actuat readili integr strong bundl well high power soft robot light driven remot control
D006108;D012371
T090;T196;T109
36,302,956
sar cov omicron variant attenu replic polar human lung epitheli cell model sar cov emerg variant concern remain major threat global health introduc infect model base upon polar human alveolar epitheli lentivirus immort haelvi cell grown air liquid interfac estim replic epidem potenti respiratori virus human lower respiratori tract haelvi cultur high permiss differ human coronavirus season influenza virus upregul various mediat follow virus infect analysi reveal signific reduc capac sar cov omicron ba ba variant propag human model compar earlier dg delta variant extend earli risk assess epidemiolog anim studi suggest reduc pathogen omicron
D000086402;D000086382
T005;T067;T047
36,302,954
dual role mtorc depend activ ubiquitin proteasom system muscl proteostasi muscl size control pik pkbakt mtorc foxo pathway integr signal growth factor energi amino acid activ protein synthesi inhibit protein breakdown mtorc activ necessari pkbakt induc muscl hypertrophi constant activ alon induc muscl atrophi show paradox base mtorc activ promot protein breakdown ubiquitin proteasom system up simultan induc ubiquitin e ligas express via feedback inhibit pkbakt proteasom biogenesi via nuclear factor erythroid like nrf muscl growth restor reactiv pkbakt nrf knockdown implic ubiquitin limit step howev pkbakt activ proteasom deplet nrf knockdown led immedi disrupt proteom integr rapid accumul damag materi data highlight physiolog import mtorc mediat pkbakt inhibit point juxtapos role up atrophi proteom integr
D046988;D025801
T123;T126;T116
36,302,952
surfac properti depend antifung activ silver nanoparticl silver nanoparticl agnp exhibit unusu biocid properti thank find wide rang applic divers field scienc industri numer research studi devot bactericid properti agnp less attent focus fungicid activ studi therefor orient toward determin impact agnp character differ physicochem properti fusarium avenaceum fusarium equiseti main hypothesi assum fungicid properti agnp character compar morpholog shape stabil agent molecul adsorb nanoparticl surfac two type agnp prepar reduct silver ion sodium borohydrid sb presenc trisodium citrat tc cysteamin hydrochlorid ch type agnp exhibit quasi spheric shape citrat stabil agnp tcsb agnp averag size nm negat charg smaller nm cysteamin cap agnp chsb agnp character posit surfac charg higher silver ion releas profil phytopathogen expos agnp three dose equal mg l h addit impact silver ion deliv form silver nitrat stabil agent agnp fungi also investig respons phytopathogen treatment evalu determin myceli growth sporul chang cell morpholog result studi show chsb agnp especi concentr mg l strong limit veget mycelium growth speci short long treatment time cell imag reveal chsb agnp damag conidia membran penetr cell tcsb agnp deposit surfac fungistat lethal effect demonstr silver ion highest concentr f equiseti speci h treatment number spore fusarium speci signific reduc independ type silver compound use general found posit charg chsb agnp fungicid negat charg tcsb agnp therebi establish stabil agent agnp surfac charg play crucial role shape fungicid properti
D000935;D053768
T121;T195;T073
36,302,951
express membran hsp molecular signatur cell activ heat shock protein hsp maintain cellular proteostasi stress investig therapeut target cancer two decad other identifi membran express form hsp mhsp previous appear restrict rapid prolifer cell exhibit metastat phenotyp use hs fluor tether mhsp inhibitor quantifi effect cell activ express mhsp human mous cell cell base assay stimul human cell induc fold increas mhsp express plasma membran suggest traffick mhsp regul tcr inflammatori mediat signal follow inject hs mous model human rheumatoid arthriti inflammatori bowel diseas detect local probe site activ diseas consist immun cell invas moreov despit rapid hepatobiliari clearanc hs demonstr efficaci reduc mean clinic score cia arthriti model result suggest mhsp express cell molecular marker cell activ potenti therapeut target chronic diseas rheumatoid arthriti
D008213;D001172
T047;T043
36,302,950
cold intoler associ factor popul studi cold intoler defin set symptom includ pain tingl numb chill stiff weak swell skin color chang exposur cold cold intoler may profound effect health relat qualiti life cross section studi investig primarili preval cold intoler second associ factor general popul tabriz simpl random sampl individu age perform popul cover emamieh health center supervis tabriz univers medic scienc telephon interview conduct particip general physician center particip posit respons two question oversensit cold experi pain discomfort expos cold cold intoler symptom sever ciss questionnair fill use cut valu defin cold intoler person receiv telephon call answer question cold relat symptom cold intoler report person respect cold intoler signific common femal peopl comorbid cold intoler led decreas qualiti job chang job person conclus cold intoler common problem general popul tabriz
D011788;D010146
T078;T184
36,302,949
three dimension character develop adult ocular vasculatur mice use toto clear ocular vasculatur critic involv mani blind diseas also popular research model explor development patholog angiogenesi develop ocular vessel complex fine orchestr sequenc event involv spatial tempor coordin hyaloid choroid retin network comprehens studi tridimension dynam microvascular remodel limit fact preserv spatial disposit ocular vascular network cumbersom use classic histolog procedur demonstr light sheet fluoresc microscopi lfsm clear mous eye follow extens virtual dissect offer solut problem best knowledg first quantif evolut hyaloid vasculatur post occlus venous remodel togeth character spatial distribut various cell popul ocular compart includ vitreous techniqu prove interest obtain insight scientif question address organ wide cell interact
D012171;D002829
T023;T024
36,302,948
data augment improv regularis sampl imbalanc blood cell imag classif due progress cell cycl durat storag classif morpholog chang human blood cell import correct effect clinic decis autom classif system help avoid subject outcom effici deep learn specif convolut neural network achiev state art perform various biomed imag classif problem howev real world data often suffer data imbal problem owe train classifi bias toward major class perform well minor class studi present imbalanc blood cell classif method utilis wasserstein diverg gan mixup novel nonlinear mixup data augment achiev oversampl minor class also present minor class focuss sampl strategi allow effect represent minor class sampl produc three data augment techniqu contribut classif perform method evalu two public avail dataset immortalis human lymphocyt cell red blood cell classif perform evalu use f score show propos approach outperform exist method dataset
D016571;D001773
T170;T025
36,302,947
cardiopulmonari work patient without fatigu month covid pathogenesi long covid symptom remain incomplet understood therefor aim determin cardiopulmonari limit month surviv covid use pulmonari function test echocardiograph studi point analysi global longitudin strain gls describ cycl myocardium deform provid better data left ventricular lv dysfunct lv eject fraction lvef valid questionnair overal consecut hospit patient includ year treat icu follow day discharg fatigu preval symptom patient fatigu symptomat overal character wors qualiti life qol score compar patient without fatigu p main due limit mobil high symptom burden pft variabl lvef normal vast major patient lvef gls signific reduc howev gls valu differ patient without fatigu conclus fatigu preval long covid symptom cohort associ wors qol main due limit mobil high burden concomit symptom patient show subtl myocardi dysfunct month surviv covid relat presenc fatigu
D000086382;D018487
T047;T046;T067
36,302,946
comparison low moder high intens aerob train equal load biomark perform rat studi investig physiolog molecular respons wistar hannov rat submit three week chronic train model similar train load twenti four wistar hanov rat random divid four group control n low intens train z n moder intens train z n high intens train z n three exercis group perform week run train three time week prescrib workload intens volum differ group increas maxim speed observ four week train three group train differ group higher rest glycogen also observ soleus muscl train exercis group compar control group also found z group higher protein content total phosphoryl gsk compar control group five week train conclus present studi show five week treadmil train base intens zone improv perform increas rest glycogen soleus muscl therefor intens modul chang train program adapt sinc differ program load equal
D012420;D010805
T056;T038
36,302,945
ferrichrom fungal type siderophor confer high ammonium toler fission yeast microorgan plant produc siderophor function transport environment iron cell well particip cellular iron use deposit biolog function divers although role primari metabol poor understood ferrichrom fungal type siderophor synthes nonribosom peptid synthetas nrps herein show ferrichrom induc adapt growth fission yeast high ammonium media ammonium prefer nitrogen sourc suppress uptak catabol less prefer nitrogen sourc leucin mechan call nitrogen catabolit repress ncr therefor growth fission yeast mutant cell leucin auxotrophi suppress presenc high concentr ammonium growth suppress cancel ferrichrom manner depend amino acid transport cat addit growth retard wild type cell excess ammonium exacerb delet nrps gene sib respons biosynthesi ferrichrom suggest intrins produc ferrichrom function suppress metabol action ammonium furthermor ferrichrom facilit growth wild type sib defici cell low glucos condit result suggest intracellular iron regul primari metabol includ ncr mediat siderophor
D012568;D064751
T104;T197;T004
36,302,944
except preserv intern organ new fossil speci freshwat shrimp caridea palaemonoidea eocen messel germani new speci extinct freshwat shrimp discov eocen deposit messel pit konservat lagersttt rare find repres specimen one show except preserv soft tissu intern part like stomach possibl gastric ossicl place branchia ovari left mandibl never describ fossil shrimp new speci bechleja brevirostri n sp character short rostrum bear dorsal spine one ventral tooth long second pereiopod strong chela one addit specimen show slight differ morpholog might belong differ speci systemat posit speci among superfamili palaemonoidea discuss well implic knowledg paleoenviron lake messel paleobiogeographi eocen
D033364;D014070
T023;T204
36,302,943
long term hospitalis survivor paediatr solid tumour franc late effect treatment childhood cancer may lead sever multipl health condit requir hospitalis aim estim hospitalis rate among childhood cancer survivor ccs franc compar general popul investig associ factor match total year solid ccs diagnos age sex birth year region resid individu french general popul linkag nation hospit discharg databas estim relat hospitalis rate rhr absolut excess risk aer relat bed day ratio rbdr use generalis linear model estim associ hospitalis survivor characterist overal rhr confid interv ci rbdr ci found neoplasm relat hospitalis highest aer per person year follow genitourinari system diseas per person year cardiovascular diseas per person year adjust analysi ccs treat chemotherapi risk ratio rr ci radiotherapi rr ci rr ci higher risk hospitalis one receiv treatment ccs treat past decad chemotherapi andor radiotherapi higher hospitalis risk main categori diagnosi general popul prevent strategi medic surveil programm may promot long term decreas hospitalis rate among css
D000076322;D009369
T078;T191
36,302,942
surgic manag trend osteoporot vertebr compress fractur year experi one institut osteoporot vertebr compress fractur ovcf gradual becom health threat elder individu treatment option controversi mani challeng remain studi aim investig manag trend ovcf singl institut cover case ovcf januari decemb total ovcf patient review ovcf common patient year old hospit stay surgeri haemorrhag rate total cost decreas year year number patient previous ovcf vari averag bone miner densiti bmd patient general decreas year year ovcf treatment rate pv pk increas rate pv combin pedicl fixat decreas patient treat bisphosphon patient treat teriparatid visual analogu scale score signific improv final follow compar preoper valu rate previous fractur correl bmd correl sex age anti osteoporosi treatment conclus year incid ovcf increas averag patient bmd worsen year although total cost continu decreas poor adher anti osteoporosi treatment prevent refractur creat sever challeng
D050815;D016103;D058866
T047;T046;T037
36,302,941
establish diagnost prognost nomogram pancreat cancer bone metastasi bone metastasi bm rare patient pancreat cancer pc often neglect initi diagnosi treatment bone metastasi associ wors prognosi studi aim perform larg data analysi determin predictor prognost factor bm pc patient develop two nomogram quantifi risk bm prognosi pc patient bm present studi review collect data patient diagnos pc surveil epidemiolog end result seer databas univari multivari logist regress analys use togeth screen valid risk factor bm pc patient independ prognost factor pc patient bm identifi cox regress analysi final two nomogram establish via calibr curv receiv oper characterist roc curv decis curv analysi dca studi includ pc patient seer databas diagnos bm risk factor bm pc patient cover age grade stage n stage tumor size primari site independ prognost factor pc patient bm includ age race grade surgeri lung metastasi auc diagnost nomogram train set test set prognost nomogram auc valu month train set test set calibr curv dca further indic satisfactori clinic consist nomogram nomogram could accur person tool predict incid bm pc patient prognosi pc patient bm nomogram help clinician make person effect treatment choic
D001855;D001859;D010190
T047;T191
36,302,940
effect safeti statin outcom patient hiv infect systemat review meta analysi statin hypolipidaem human immunodefici virus hiv posit individu howev effect caus mortal rate discontinu unclear conduct systemat review evalu impact statin caus mortal discontinu rate risk advers effect among hiv patient high activ antiretrovir therapi haart search four electron databas incept octob trial cohort studi evalu effect statin treatment versus placebo hiv patient forti seven studi involv patient includ statin associ signific lower risk discontinu rr ci p risk caus mortal rr ci p advers effect rr ci p diabet mellitus rr ci p statin treatment lower statist signific compar placebocontrol statin treatment associ trend higher statist insignific risk myalgia rr ci p elev creatin kinas rr ci p liver enzym activ rr ci p clinician consid nocebo effect effect manag plwh statin present common advers effect myalgia elev level creatin kinas liver enzym
D019161;D015658
T121;T047;T109
36,302,939
silico compar transcriptom analysi identifi hub lncrnas mrnas brain metastat small cell lung cancer sclc small cell lung cancer sclc particular lethal subtyp lung cancer metastat lung tumour lead death lung cancer predict prevent tumour metastasi crucial essenti patient surviv henc current studi focus comprehens analysi lung cancer patient differenti express gene deg brain metastasi cell line deg analys kegg go databas critic biolog process pathway enrich deg addit perform protein protein interact ppi genemania kaplan meier surviv analys deg articl focus mrna lncrna deg lc patient brain metastasi under molecular mechan express data gather gene express omnibus databas gse demonstr distinct gene express brain metastat sclc patient gene express analys show gene involv metastat sclc ppi analysi reveal two hub gene cat app result articl present three lncrnas includ xlocl loc xlocl also notabl mrnas close relat brain metastasi lung cancer may role epitheli mesenchym transit emt tumour cell
D062085;D055752;D008175;D001932
T123;T191;T114
36,302,937
synthesi preliminari biolog evalu gabactyzin benactyzin gaba mutual prodrug organophosph antidot organophosph op inhibitor acetylcholinesteras deleteri effect central nervous system clinic manifest op poison includ convuls repres under toxic neuro patholog process lead perman neuron damag neurotox mediat cholinerg gabaerg glutamaterg nmda system pharmacolog intervent op poison design mitig specif neuro patholog pathway use anticholinerg drug gabaerg agent benactyzin combin anticholinerg anti nmda compound base previous develop novel gaba deriv prodrug base perphenazin treatment schizophrenia nortriptylin neuropath pain describ synthesi preliminari test mutual prodrug ester benactyzin gaba assum ester cross blood brain barrier undergo hydrolysi releas benactyzin gaba expect act synergist combin releas compound brain offer sever advantag current op poison treatment protocol improv efficaci safeti profil inhibitori properti gaba expect counteract anticholinerg cognit advers effect benactyzin enhanc chemic stabil compar benactyzin alon present preliminari result anim studi show promis result earli gabactyzin administr
D011355;D002619;D062025
T120;T131;T037
36,302,936
activ carbon deriv sugarcan modifi natur zeolit effici adsorpt methylen blue dye experiment theoret approach introduct activ carbonnatur zeolit acnz effici reliabl nanoadsorb enhanc methylen blue mb dye adsorpt calcin sugarcan wast various temperatur c activ carbon ac form xrd sem use character prepar adsorb adsorpt measur remov mb dye made impact ph begin mb concentr contact time maximum acnz adsorpt capac mb dye c ph acnz mass mg found approxim mgg initi concentr ppm pseudo second order kinet model temkin isotherm model describ adsorpt process temkin model show adsorpt energi kcalmol indic mb acnz adsorpt process occur physic mont carlo mc simul studi support find show van der waal dispers forc respons mb molecul physic adsorpt acnz adsorb thought strong contend water remedi
D017641;D031786;D014874
T131;T197;T002
36,302,935
pattern patient polypharmaci adult popul korea polypharmaci rise global preval grow public health burden use larg repres nationwid korean cohort n conduct retrospect cross section studi aim identifi subpopul patient polypharmaci character uniqu pattern cluster analysi patient age year prescrib least one medic includ studi six cluster identifi cluster most includ patient hospit long time day cluster consist patient disabl highest mean number prescript drug medic cluster group low incom patient cluster group high incom patient frequent day visit hospitalsclin place cluster most elder year femal cluster compris most middl age year male p patient cluster prescrib medic outpati visit day cluster p given limit health care resourc individu identifi phenotyp may preferenti candid particip intervent program optim medic use
D019338;D055553
T061;T121
36,302,934
dynam analysi optim control consid cross transmiss variat inform cross transmiss inform profound influenc progress scienc technolog disciplin integr field educ work knowledg gain viral recombin variat covid transmiss appli inform transmiss virus recombin virus variat similar cross inform fusion phenomena inform transmiss simr model inform cross variat construct local global asymptot stabil inform free equilibrium inform exist equilibrium analyz addit basic reproduct number formula see text model calcul optim control strategi herebi propos promot cross transmiss inform generat variant inform numer simul support result theoret analysi sensit system toward certain control paramet particular result show strengthen inform cross promot generat variant inform furthermor encourag inform exchang enhanc educ improv generat inform cross inform variat
D000086382
T047;T067
36,302,933
effect mesenchym stem cell renovascular diseas preclin clinic studi systemat review meta analysi renal arteri stenosi ras caus sever renovascular hypertens worsen kidney function increas cardiovascular morbid accord recent studi mesenchym stem cell mscs administr promis therapi improv ras outcom meta analysi aim evalu therapeut effect msc therapi ras perform search medlin web scienc embas cochran librari incept octob includ preclin clinic studi meta analysi preclin studi pool result indic anim treat mscs lower level systol blood pressur sbp smd ci p serum creatinin scr smd ci p plasma renin activ pra smd ci p studi also reveal increas level renal blood flow rbf stenot kidney stk smd ci p glomerular filtrat rate gfr stk smd ci p clinic studi cortic perfus fraction hypoxia contralater kidney clk allevi msc therapi taken togeth meta analysi reveal mscs therapi might promis treatment ras howev due discrep preclin studi earli clinic trial outcom msc therapi could nt recommend clinic care moment high qualiti random control clinic trial need valid conclus standard mscs protocol
D045164;D059630;D012078;D006978
T061;T047;T025
36,302,932
ramp shape neural tune support grade popul level represent object scene continuum easili perceiv spatial scale depict pictur regardless whether small space eg close view chair much larger space eg entir class room human visual system encod continu dimens investig under neural code depict spatial scale examin voxel tune topograph organ brain respons creat naturalist yet care control stimuli construct virtual indoor environ render seri snapshot smooth sampl close view central object far scale view full environ object scene continuum human brain respons measur posit use function magnet reson imag find evid smooth topograph map object scene continuum cortex instead observ larg swath cortex oppos ramp shape profil highest respons one end object scene continuum small region show weak tune intermedi scale view howev consid popul code entir ventral occipito tempor cortex found smooth linear represent object scene continuum result togeth suggest depict spatial scale inform encod parametr larg scale popul code across entir ventral occipito tempor cortex
D014793
T023;T029
36,302,931
investig bactericid effect mid infrar free electron laser escherichia coli rapid increas number bacteria resist mani common use antimicrobi agent global spread becom major problem worldwid particular periodont diseas local infect grow need treatment method primarili involv antimicrobi agent antimicrobi photodynam therapi apdt attract attent studi bactericid effect mid infrar free electron laser mir fel e coli investig basic studi examin applic mir fel select excit molecular vibrat due wavelength tunabl apdt optim irradi wavelength examin studi determin infrar spectrum bacteria obtain use fourier transform infrar spectroscopi five irradi wavelength select ft ir spectrum found bactericid effect wavelength mark stronger observ wavelength wavelength correspond amid ii band bacteri surviv rate decreas signific irradi time increas contrari irradi neodymium dope yttrium aluminum garnet nd yag laser exhibit distinct bactericid effect morpholog chang observ mir fel irradi suggest bacteri organell molecul may target mir fel irradi exact target identifi furthermor temperatur chang induc cultur medium laser irradi c room temperatur result suggest bactericid effect mir fel deriv photochem reaction involv infrar photon sinc e coli usual kill heat c min longer
D004926;D004927
T047;T007
36,302,930
sens nitril thz spectroscopi urin vapour cancer patient subject chemotherapi thz nonstationari high resolut spectromet base semiconductor superlattic multipli appli investig dynam urin composit cancer patient treat chemotherapi molecular urin composit healthi volunt cancer patient compar contrast found set nitril either appear chemotherapi increas content expect result bio chemic damag liver damag detect stage exist clinic method identifi nitril candid larg scale systemat test toward marker nephrotox chemotherapi earli stage treatment convent diagnost identifi substanti organ damag compar metabolit concentr dynam side effect chemotherapi might help individu patient prone sever complic correct treatment devic game changer thz spectroscopi liquid allow span four differ frequenc rang general evalu substanc found liquid select spectral interv bypass strong absorpt line substanc water ammonia may otherwis mask detect target metabolit
D009570;D009369
T121;T191;T109
36,302,929
fabric character electrospun nanofib use biocompat polym sustain releas venlafaxin recent drug control releas nanotechnolog gain special attent biomedicin work focus develop novel electrospun polymer nanofib nfs buccal deliveri ven avoid hepat metabol enzymat degrad git develop effect control drug releas optim nfs obtain blend polylact acid pla poli caprolacton pcl fix ratio character morpholog drug load ftir xrd dsc vitro drug releas ex vivo permeabl blend nfs assess use chicken pouch mucosa compar ven suspens follow histopatholog examin cytotox effect three differ cell line use wst assay sem morpholog refer defect free uniform nfs pla pcl plapcl mat fiber diamet rang nm physico thermal character nfs depict drug success load amorph state plapcl nfs vitro releas nfs substanti bi phasic profil initi burst releas initi h prolong cumul releas pattern reach h follow non fickian diffus mechan ex vivo permeat emphas major enhanc sustain drug releas notic decreas permeabl drug nfs cytotox data found ic ven alon gml ven nfs record ic valu gml plain nfs show lowest toxic ic gml oral epitheli cell oec histopatholog cell toxic studi demonstr preserv mucos architectur preclin safeti develop plapcl nfs promis drug carrier introduc step chang improv psychiatr treatment healthcar
D057139
T073
36,302,928
smartphon base ecolog momentari assess reveal mental health benefit birdlif mental health benefit everyday encount birdlif mental health poor understood previous studi typic reli retrospect questionnair artifici set up littl ecolog valid present studi use urban mind smartphon applic examin impact see hear bird self report mental wellb real life context sampl particip complet total ecolog momentari assess april octob everyday encount birdlif associ time last improv mental wellb improv evid healthi peopl also diagnosi depress common mental ill across world find potenti implic environment wildlif protect mental healthcar polici specif measur aim preserv increas everyday encount birdlif urban area implement
D000072860;D063731
T060;T170
36,302,927
effect proton boron fusion therapi pbft cellular level present work introduc framework investig effect proton boron fusion therapi pbft cellular level framework consist cell array generat program coupl phit mont carlo packag dedic termin base code editor develop work framework enabl user model larg cell array normal boron random boron fill cytoplasm investig under mechan pbft found alpha particl neutron could produc absenc boron main nuclear reaction induc proton interact c n nuclei effect pbft high depend incid proton energi sourc size cell array size buffer medium thick layer concentr distribut boron cell array quantit assess effect pbft total energi deposit alpha particl differ case determin number alpha particl hit cell cytoplasm nucleus normal ppm boron determin obtain result develop tool would use futur develop pbft object determin effect treatment modal
D016754;D061766
T061
36,302,925
proteom consequ tda defici saccharomyc cerevisia protein kinas tda essenti hxk hxk serin phosphoryl hexokinas hxk saccharomyc cerevisia dual function hexokinas act glycolyt enzym involv transcript regul glucos repress gene relief glucos repress accompani phosphoryl hxk serin attribut protein kinas tda explor role tda beyond hxk phosphoryl proteom consequ tda defici investig differ gel electrophoresi dige compar wild type tda delet mutant addit address possibl consequ glucos repressionderepress grown wv glucos total eight protein spot exhibit minimum twofold enhanc reduc fluoresc upon tda defici detect identifi mass spectrometri among spot ident besid expect hxk two proteoform hexokinas hxk target proteom analys conjunct dige demonstr tda indispens hxk hxk phosphoryl serin thirti six glucos concentr depend protein spot identifi simpl method improv spot quantif approxim spot rotate symmetr solid present along new data quantiti hxk hxk serin phosphoryl form high low glucos growth condit tda delet mutant exhibit alter growth high low glucos condit altern carbon sourc also invertas activ serv report glucos derepress signific alter instead involv tda oxid stress respons suggest
D006593;D011494;D012441;D029701
T004;T126;T116
36,302,923
lime enhanc longev wheat seed produc acid soil environ plant grow acid soil interfer nutrient concentr physiolog qualiti seed hypothesi test use wheat seed model crop grown tropic soil without lime applic twelv year show lime provid remark enhanc soil chemistri seed composit without alter seed germin vigor also favor product seed addit molecular mechan extend longev result indic applic lime mitig acid tropic soil ensur product seed enhanc chemic composit longer life span
D012987;D014908
T168;T002;T167
36,302,922
sar cov world pandem recurr wave control variant evolut vaccin campaign understand time evolut covid pandem need plan econom tune sanitari polici quantit inform recurr epidem wave elus work describ statist physic studi subsequ wave epidem spread covid disclos frequenc compon epidem wave pattern two year unit state unit kingdom japan countri taken repres case differ contain polici mitig usa uk zero covid japan polici supercrit phase spread identifi interv ric index use wavelet transform infect fatal wave get spectral analysi show domin compon around day data world dynam clear indic also crossov differ phase due enforc vaccin campaign japan unit kingdom observ emerg infect wave long period compon day vaccin campaign result indic slow epidem spread dynam due vaccin campaign final find intrins differ infect fatal wave point non trivial variat lethal due differ gene variant
D058873;D000086382
T047;T067
36,302,921
diverg regul basement membran traffick human macrophag cancer cell macrophag cancer cell popul posit navig basement membran barrier either mobil proteolyt enzym deploy mechan forc nevertheless relat role ident proteinas depend independ mechan use macrophag versus cancer cell transmigr basement membran barrier harbor physiolog relev coval crosslink remain ill defin herein macrophag cancer cell shown mobil membran anchor matrix metalloproteinas proteolyt remodel nativ basement membran isol murin tissu infiltr under interstiti matrix ex vivo absenc proteolyt activ howev macrophag deploy actomyosin generat forc transmigr basement membran pore therebi provid cell proteinas independ access interstiti matrix simultan exert global effect macrophag transcriptom contrast cancer cell invas activ reliant metalloproteinas activ neither mechan forc chang nuclear rigid rescu basement membran transmigr studi identifi membran anchor matrix metalloproteinas key proteolyt effector basement membran remodel macrophag cancer cell also defin diverg invas strategi use normal neoplast cell travers nativ tissu barrier
D005109;D009369
T191;T024
36,302,918
fundament concept screen microorgan biotechnolog applic mini review microbi biotechnolog use microorgan deriv generat industri andor environment product impact daili life modern biotechnolog use proteom metabolom quantum processor massiv sequenc method yield promis result microorgan howev fundament concept microbi biotechnolog focus specif search microorgan natur sourc correct analysi implement larg scale process mini review focus method use isol select microorgan biotechnolog potenti empath import concept microbi biotechnolog work review state art recent year select character microorgan basic approach understand import fundament concept field biotechnolog carri proper select isol sourc design suitabl select criteria accord desir activ generat substanti chang develop biotechnolog three decad exampl includ taq polymeras pcr method crispr technolog object mini review establish general idea screen microorgan base basic concept biotechnolog left asid sever articl maintain import basic concept impli develop modern biotechnolog
D001709;D040901
T091
36,302,916
small molecul target disord transactiv domain androgen receptor induc format collaps helic state intrins disord protein adopt well defin structur physiolog condit implic mani human diseas small molecul target disord transactiv domain androgen receptor enter human trial treatment castrat resist prostat cancer crpc structur mechanist rational exist explain inhibit mechan relat potenc util atom molecular dynam comput simul elucid atom detail bind mechan compound epi epi androgen receptor simul reveal compound bind interfac two transient helic region induc format partial fold collaps helic state find epi bind androgen receptor tight epi identifi network intermolecular interact drive higher affin bind result suggest strategi develop potent androgen receptor inhibitor general strategi disord protein drug design
D011944;D064129
T191;T116;T192
36,302,915
mobil applic use dcdm cloud base automat plant diseas detect farm plethora difficult respons plant monitor one also urgent need increas number altern techniqu detect plant diseas lack agricultur agricultur support sector india provid employ great major countri peopl india agricultur product countri direct connect countri econom growth rate order sustain healthi plant develop varieti process must follow includ consider environment factor water suppli manag optim product crop ineffici uncertain outcom use tradit method water lawn devast world agricultur produc caus diseas attack annual basi difficult execut activ manual identifi plant diseas essenti decreas loss agricultur product busi addit diagnos wide rang plant ailment method also includ identif infect prophylact step detail descript farm base modul includ numer cloud data center data convers devic accur monitor manag farm inform environment element procedur involv imag plant visual obvious sign order identifi diseas recommend therapi use conjunct applic minim harm increas product result suggest approach would help agricultur irrig sector plant area modul fit mobil camera captur imag plant area plant inform save databas access comput internet access plan record inform plant name type ill afflict imag plant wide rang applic bot use collect imag various plant well prevent diseas transmiss ensur inform given retain internet data collect store cloud storag becom essenti regul condit accord find research wide imag healthi ill fruit plant leav real time diagnosi plant leaf diseas may done accuraci laboratori environ util photograph analyz photo construct dcdm deep learn model use train addit model data set use cloud base imag diagnost classif servic consum may receiv inform condit less second averag process requir averag
D000067917;D004784;D063731;D010935
T047;T170;T066;T057
36,302,912
distinct organ two cortico cortic feedback pathway neocort feedback critic attent predict learn mechan understand function requir deciph cell type wire recent studi reveal feedback primari motor primari somatosensori area mice disinhibitori target vasoact intestin peptid express interneuron addit pyramid cell unknown whether circuit motif repres general cortico cortic feedback organ principl show contrast wire rule feedback higher order lateromedi visual area primari visual cortex preferenti activ somatostatin express interneuron function feedback circuit tempor sharpen feed forward excit elicit transient increas follow prolong decreas pyramid cell activ sustain feed forward input howev feed forward transient input primari motor primari somatosensori cortex feedback facilit burst lateromedi area primari visual cortex feedback increas time precis find argu multipl cortico cortic feedback motif implement differ dynam non linear oper
D007395;D017966
T025
36,302,909
avers memori format human involv amygdala hippocampus phase code memori avers event central surviv becom maladapt psychiatr disord memori enhanc emot event thought depend amygdala modul hippocamp activ howev neural dynam amygdala hippocamp communic emot memori encod remain unknown use simultan intracrani record structur human patient show success emot memori encod depend amygdala theta phase hippocamp gamma activ neuron fire coupl phase differ subsequ rememb vs rememb emot stimuli translat time period enabl lag coher amygdala downstream hippocamp gamma result reveal mechan wherebi amygdala theta phase coordin transient amygdala hippocamp gamma coher facilit avers memori encod pace lag gamma coher via amygdala theta phase may repres general mechan amygdala relay emot content distant brain region modul aspect cognit attent decis make
D008568;D000679
T023;T041
36,302,906
intramyocardi hemorrhag drive fatti degener infarct myocardium sudden blockag arteri suppli heart muscl contribut million heart attack myocardi infarct mi around world although open arteri reperfus save mi patient immedi death approxim patient go develop chronic heart failur chf die within year period howev patient acceler toward chf other remain unclear show use larg anim model reperfus mi intramyocardi hemorrhag damag form reperfus injuri evid near reperfus st elev mi patient drive delay infarct heal central respons continu fatti degener infarct myocardium contribut advers remodel heart specif show fatti degener hemorrhag mi zone stem iron induc macrophag activ lipid peroxid foam cell format ceroid product foam cell apoptosi iron recycl also demonstr time reduct iron within hemorrhag mi zone reduc fatti infiltr direct heart toward favor remodel collect find elucid mis destin chf help defin potenti therapeut strategi mitig post mi chf independ mi size
D009203;D006333
T047;T046
36,302,892
estim regener potenti pannonian sand region help priorit ecolog restor intervent restor priorit help determin optim restor intervent nation region spatial plan creat sustain landscap maintain biodivers investig differ forest stepp veget type pannonian sand region provid restor recommend conserv manag polici research creat spatial trajectori base local neighbour old field regener capac estim hungarian habitat map databas compar trajectori differ mesoregion determin environment predictor possibl influenc mesoregion level use random forest model trajectori indic type passiv activ restor intervent need includ increas connect control invas speci introduc nativ speci better restor result achiev vicin larger semi natur area specif site condit must also taken account priorit also propos larg scale grassland restor abandon agricultur field instead industri forest plantat afforest non nativ speci
D000080463;D003247
T078;T197;T069;T081;T064
36,302,891
evolut natur aris sar cov defect interf particl defect interf di particl aris virus propag condit parent virus replic packag interfer viral expans much interest develop dis anti viral agent character di particl aros follow serial passag sar cov high multipl infect promin dis identifi lost sar cov genom capabl attenu parent viral titer synthet variant di genom also interfer infect use condit gene deliveri vehicl addit di genom encod nsp fusion protein capabl attenu viral replic result identifi natur select defect viral genom emerg stabli propag presenc parent virus
D003673;D000086382
T005;T067;T047