PMID
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36.4M
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36,302,889
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aetiolog clinic present central nervous system infect vietnames patient prospect studi knowledg clinic present central nervous system cns infect causat pathogen crucial appropri diagnosi rapid initi appropri treatment prevent sever neurolog sequela aim studi understand aetiolog cns infect base clinic present vietnames patient prospect hospit base cohort studi conduct may may screen patient clinic suspect cns infect fungal bacteri viral pathogen use cerebrospin fluid csf blood cultur addit dna rna extract csf sampl subject nucleic acid test nat select panel bacteri viral fungal pathogen least one pathogen could detect n patient main pathogen caus cns infect streptococcus sui n neisseria meningitidi n follow herp simplex virus n klebsiella pneumonia n pathogen identifi case patient bacteri cns infect signific older wors outcom lower glasgow coma scale gcs higher rate speech impair neck stiff patient viral tubercul cns infect northern vietnam adult most affect bacteri cns infect sever clinic cours wors outcom compar viral tubercul cns infect clinician awar region occurr pathogen initi rapid appropri diagnosi treatment
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D002494;D020806
|
T047
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36,302,888
|
cross section studi chines women facial skin status environment factor individu lifestyl geograph environment pollut condit affect facial skin health effect skin appear elucid studi aim describ skin barrier skin tone characterist chines subject accord lifestyl environment condit use vitro measur total women age year recruit repres chines citi eight skin paramet hydrat sebum ph transderm water loss individu type angl melanin index erythema index yellow measur use noninvas instrument individu lifestyl data also collect data four meteorolog factor air temperatur relat humid sunshin durat wind speed seven air pollut indic air qualiti index fine particul matter breathabl particul matter sulfur dioxid nitrogen dioxid carbon monoxid ozon collect citi china meteorolog administr facial skin characterist differ signific citi facial skin barrier characterist skin tone show region differ better skin barrier associ western region indic high skin hydrat sebum secret low ph valu accord valu transderm water loss lighter darker skin tone found western southern region respect environment condit affect facial skin status air pollut induc facial skin issu fine particul matter nitrogen dioxid contribut individu lifestyl affect facial skin barrier skin tone
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D000393;D000397
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T131;T069;T080
|
36,302,886
|
develop lipid nanoparticl liposom refer materi ii cytotox profil lipid base nanocarri one effect drug deliveri system evid recent covid mrna vaccin main object studi evalu toxic six lipid base formul three surfac charg anion neutral cation establish certifi refer materi crms liposom sirna load lipid nanoparticl lnp sirna cytotox assess prolifer assay adher non adher cell line high concentr three lnp sirna affect viabil suspens cell lnp sirna non toxic adher cell convent use concentr systemat evalu use multipl vial repeat test run three liposom three lnp sirna formul show toxic hl cell gml respect extend treatment low concentr lnps affect viabil suspens cell adher cell h interest hl cell condit viabl treat cation lnp sirna h taken togeth anion cation neutral lipid formul non toxic cell may explor order develop drug carrier
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D000086382;D053758;D000970
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T121;T073;T067;T109;T047
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36,302,883
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determin univers student covid vaccin intent behavior vaccin hesit major challeng health author societi covid pandem general determin vaccin intent behavior includ sociodemograph health relat psycholog communic relat factor vari relev differ type vaccin countri target group predictor univers student covid vaccin behavior suffici studi use german univers exampl base onlin survey univers student investig factor relat likelihood vaccin covid b vaccin intent among vaccin summer psycholog factor show high relev field studi trust use certain media inform channel found import determin student vaccin decis find help better understand univers student vaccin behavior develop implement tailor strategi campaign
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D033182;D000086382
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T047;T067;T041
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36,302,882
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research equival thermal network model rare earth giant magnetostrict transduc crucial import giant magnetostrict transduc gmts design quick accur analysi temperatur distribut advantag low calcul cost high accuraci thermal network model develop thermal analysi gmt howev exist thermal model limit describ complic thermal behavior gmts research focus steadi state incap captur temperatur varianc temperatur distribut giant magnetostrict gmm rod general assum uniform wherea temperatur gradient gmm rod remark due poor thermal conduct non uniform distribut gmm loss seldom introduc thermal model therefor transient equival thermal network tetn model gmt establish paper consid aforement three aspect first base structur work principl longitudin vibrat gmt thermal analysi carri follow accord heat transfer process gmt tetn model establish correspond model paramet calcul final accuraci tetn model tempor spatial analysi transduc temperatur verifi simul experi
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D014159;D006358
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T074;T070
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36,302,880
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associ covid stress cope mechan stress relat oral condit among egyptian adult cross section studi present studi investig associ covid stress oral condit includ gingiv oral hygien oral ulcer dri mouth cross section studi collect data adult communiti set alexandria egypt octob februari gingiv condit oral hygien assess use gingiv plaqu indic particip ask experienc oral ulcer past week dri mouth past year covid fear cope assess use covid stress scale css brief resili cope scale brcs respect oral health behavior assess use world health organ questionnair regress analys use assess associ depend variabl clinic assess gingiv plaqu indic report presenc oral ulcer dri mouth explanatori variabl css brcs adjust confound covid status oral health behavior smoke age year sex highest educ level respons rate mean sd age femal report complet high school higher educ mean sd plaqu gingiv indic respect report presenc oral ulcer report xerostomia lower plaqu score associ higher covid contamin fear b ci higher compuls check reassur seek b ci lower gingiv score associ higher covid contamin fear b ci higher odd report dri mouth associ greater fear covid socioeconom consequ aor ci lower cope score aor ci find suggest associ covid specif stress stress relat oral condit shed light possibl link mental oral health emphas import integr plan care servic
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D000086382;D019226;D005891;D014987
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T047;T067
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36,302,879
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puls width intens effect puls electr field cancer normal skin cell microsecond puls electr field pef previous use various tumour therapi gene therapi electrochemotherapi irrevers electropor ire due demonstr abil howev recent nanosecond puls electr field nspef also use potenti tumor therapi via induc cell apoptosi immunogen cell death prevent recurr metastasi interact intracellular organell larg proport exist vitro studi nspef cell also suggest cell necrosi swellingbleb induc replic potenti effect cell suggest complic process requir investig therefor studi investig effect puls width intens nspef murin melanoma cell b normal murin fibroblast cell l electromagnet simul vitro experi examin evolut pattern potenti differ electr field intracellular compart simul shown differenti effect nspef normal cancer skin cell explain well result observ report experi addit model provid clear evid hundr ns pef may caus mix mode effect ie cocktail effect includ cell electropor ire due threshold voltag induc plasma membran well cell apoptosi biolog effect caus interact intracellular compart vitro experi puls rang hundr nanosecond show possibl differenti cytotox threshold electr field intens b cell l cell
|
D053672;D012878
|
T061;T191
|
36,302,878
|
morphometr descript koala humerus use microcomput tomographi current prognosi success return function koala appendicular fractur poor despit common fractur type result success rehabilit forelimb particular humerus play critic role stabilis support climb tree success rehabilit therefor requir adequ intern stabilis promot bone heal faster return function current knowledg koala limb bone morphometri lack would provid use clinic insight futur orthopaed research particular regard recommend regard implant size type studi microcomput tomographi micro ct use describ bone length intern extern diamet cortic thick five transvers level along humerus skelet matur koala cadav qualit descript also made regard bone featur deem clinic relev potenti fractur repair techniqu mean humer length mm ci mm mediolater diamet greater craniocaud diamet measur level diaphysi distal taper medullari caviti diaphys cortic relat homogen slight distal thicken medial cortic thickest along entir bone bone protuber deltoid supin ridg project way later surfac bone medial surfac remain relat uniform distal deltoid ridg humerus curv caudal termin craniocaud flatten distal epiphysi morphometr descript provid studi serv use refer futur research guid orthopaed surgeri improv prognosi koala humer fractur
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D048368;D006810
|
T015;T037
|
36,302,876
|
automat identif earli ischem lesion non contrast ct deep learn approach earli ischem lesion non contrast comput tomogram ncct acut stroke subtl need confirm magnet reson mr imag treatment decis make retrospect includ ncct slice normal subject ischem stroke patient onset h correspond mr slice refer standard prospect registri chang gung research databank model select ncct slice preprocess fed five differ pre train convolut neural network cnn model includ visual geometri group vgg residu network incept resnet v incept v incept v model deriv custom vgg model could achiev accuraci sensit f score specif ap use tenfold cross valid method outperform pre train vgg model model evalu custom vgg model could correct identifi subject includ ischem stroke patient normal subject reach sensit identifi ischem ncct slice irrespect supratentori infratentori lesion custom vgg cnn model success identifi presenc earli ischem lesion ncct slice use concept automat featur learn studi proceed detect locat ischem lesion
|
D000077321;D020521;D000083242
|
T047;T066
|
36,302,875
|
quiescent innat adapt immun respons maintain long term integr corneal endothelium reconstitut allogen cell inject therapi studi aim clarifi immunogen acquir innat immun respons cultur human corneal endotheli cell hcec appli cell inject therapi newli establish modal corneal endothelium failur thirti four patient corneal endotheli failur receiv inject allogen hcec suspens anterior chamber sign immunolog reject observ patient year postop follow period cell inject therapi success patient treat endotheli failur penetr keratoplasti one patient descemet membran strip autom endotheli keratoplasti failur elispot assay perform allo mix lymphocyt reaction alloantigen ident inject hcec elicit spars ifn specif spot peripher blood mononuclear cell patient receiv hcec inject therapi generat simpl smooth graft host junction without wound stress inject cbl cec anterior chamber balbc mice reject cbl cornea week ago induc sign inflammatori reaction second challeng alloantigen collect inject hcec cell suspens aqueous humor induc immun toler contribut surviv reconstitut endothelium
|
D004728;D003316
|
T047;T024
|
36,302,874
|
climat chang speci facilit affect recruit macroalg marin forest marin forest shrink global due sever anthropogen impact includ climat chang forest form macroalga cystoseira sl speci particular sensit environment condit eg temperatur increas pollut sediment especi earli life stage howev much known respons interact effect ocean warm ow acidif oa driver also affect perform surviv crustos corallin alga associ understori speci like play role recruit later succession speci forest form macroalga test interact effect elev temperatur low ph speci facilit recruit cystoseira compressa demonstr interact effect ow oa negat affect recruit c compressa associ corallin alga neogoniolithon brassica florida densiti recruit lower combin ow oa size negat affect temperatur increas posit affect low ph result studi show interact effect climat chang presenc crustos corallin alga negat impact recruit cystoseira sl speci new restor techniqu recent open door marin forest restor result show interact multipl driver speci interact consid achiev long term popul sustain
|
D012624;D000461
|
T002;T204
|
36,302,873
|
analysi distribut ledger technolog industri manufactur recent year industri manufactur undergon massiv technolog chang embrac digit autom toward vision intellig manufactur plant aim maxim effici profit product import goal enabl flexibl manufactur custom desir individu product manufactur adjust market demand manufactur servic support manufactur plant use differ tenant util machin plant offer differ provid enabl pay per use busi model distribut ledger technolog dlt viabl option establish decentr trust traceabl thus paper studi potenti dlt technolog effici intellig integr dlt base solut manufactur environ propos general framework adapt dlt manufactur introduc use case share manufactur util studi communic comput effici select dlts resourc constrain wireless iot network
|
D003132;D013678
|
T078;T091;T097;T081;T057
|
36,302,872
|
photoinduc invers vulcan invers vulcan iv element sulfur generat sulfur rich function polym attract much recent attent howev harsh reaction condit requir even metal catalyst constrain rang feasibl crosslink report photoinduc iv enabl reaction ambient temperatur great broaden scope substrat product condit enabl volatil gaseous alken alkyn use iv lead sustain altern environment harm plastic hitherto inaccess densiti function theori calcul reveal differ energi barrier thermal catalyt photoinduc iv process protocol circumv long cure time common iv generat h product produc high molecular weight polym g mol almost atom economi photoinduc iv strategi advanc fundament chemistri iv potenti industri applic generat materi wast feedstock
|
D013455;D011108
|
T123;T121;T104;T196;T122
|
36,302,865
|
quantifi neuro motor correl awak deep brain stimul surgeri use markerless track expand applic deep brain stimul dbs therapi drive inform grow understand diseas pathophysiolog innov neurosurg care neurophysiolog target mainstay identifi optim motor respons target remain larg unchang decad util deep learn base comput vision relat comput method develop effect simpl intraop approach object correl neural signal movement autom standard otherwis manual subject process identifi ideal dbs electrod placement kinemat extract video record intraop motor test use train deep neural network compar multi unit activ record subthalam nucleus neuro motor correl quantifi use dynam time warp strength given comparison measur compar null distribut compos relat neuro motor correl object measur compar clinic determin record surgic case note seven dbs case treatment parkinson diseas distinct motor test epoch extract clear clinic determin made neuro motor correl deriv autom system compar favor expert clinic decis make post hoc comparison although follow studi necessari determin improv correl detect lead improv outcom improv classif neuro motor relationship autom system develop enabl clinician maxim therapeut impact dbs also provid avenu improv continu care treat patient
|
D046690;D020531;D010300
|
T061;T023;T047
|
36,302,863
|
live biobank canin mammari tumor organoid compar model human breast cancer mammari tumor dog hold great potenti natur occur breast cancer model translat oncolog share environment risk factor key histolog featur hormon receptor express pattern prognost factor genet characterist human counterpart aim develop vitro tool allow function analysi canin mammari tumor cmt poor understand under biolog drive growth heterogen tumor establish long term cultur organoid line dog includ organoid deriv normal mammari epithelium benign lesion cmt organoid recapitul key morpholog immunohistolog featur primari tissu deriv includ hormon receptor status furthermor genet characterist driver gene mutat dna copi number variat singl nucleotid variant conserv within tumor organoid pair show cmt organoid suitabl model vitro drug assay use investig whether specif mutat predict therapi outcom specif certain cmt subtyp pikca mutat estrogen receptor posit simpl carcinoma valuabl set preclin model high relev human breast cancer research addit could genet modifi cmt organoid use perform pool crisprca screen librari represent accur maintain summari present robust vitro preclin model use translat research organoid normal benign well malign mammari tissu propag anim studi tumorigenesi
|
D001943;D015674
|
T191
|
36,302,862
|
revisit covid fatal rate altitud associ comprehens analysi emerg covid virus led pandem stagger morbid mortal evid show pre exist condit environment factor associ wors covid outcom among condit altitud particular interest altitud shown influenc morbid mortal multipl chronic patholog cardiovascular diseas chronic obstruct pulmonari diseas lung cancer covid fatal rate associ altitud well find disput therefor revisit assess comprehens analysi relationship covid fatal rate altitud mountain region unit state consid effect addit comorbid sociodemograph factor general addit model gam approach use one year counti data adjust popul densiti perform evalu associ within state whole region analysi reveal consist effect covid case fatal rate decreas higher altitud even control pre exist condit certain demograph variabl summari work present provid evid suggest protect effect high altitud like influenc physiolog factor demograph trend associ life high altitud must also consid
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D000086382
|
T047;T067
|
36,302,859
|
reconstruct eight centuri streamflow tibetan plateau reveal contrast region variabl strong nonstationar short instrument streamflow record south east tibetan plateau setp limit understand full rang long term variabl streamflow could great impact freshwat resourc one billion peopl downstream reconstruct eight centuri ce annual streamflow monsoon asia drought atlas five headwat region across setp find two region pattern includ northern yellow yangtz lancang mekong southern nu salween yarlung zangbo brahmaputra setp region show ten contrast wet dri period divid line region moistur regim n identifi demonstr strong tempor nonstationar streamflow variabl reveal much greater highlow mean flow period term durat magnitud most pre instrument wetter condit yarlung zangbo brahmaputra drier condit river contrast frequenc extrem flow instrument period yangtz nu salween yarlung zangbo brahmaputra increas relat pre instrument period
|
D045483;D055864
|
T070
|
36,302,854
|
blue green food web respond differ elev land use aquat blue terrestri green food web part landscap remain unclear whether respond similar share environment gradient use empir communiti data hundr site across switzerland synthesi interact inform form metaweb show infer blue green food web differ structur ecolog properti along elev among various land use type specif green food web modular structur increas elev overlap consum diet nich decreas opposit pattern observ blue food web differ blue green food web particular pronounc farmland domin habitat indic anthropogen habitat modif modul climat effect food web differ blue versus green system find indic general structur differ blue green food web suggest potenti diverg futur alter land use climat chang
|
D020387;D017753
|
T070;T082
|
36,302,851
|
genom signatur associ mainten genom stabil venom turnov two parasitoid wasp parasitoid wasp rapid develop model evolutionari biolog present chromosom genom two anastatus wasp japonicus fulloi leverag genom studi two fundament question genom size evolut venom evolut anastatus show much larger genom known among wasp unexpect recent burst ltr retrotransposon import sever genom innov includ piwi gene famili expans ubiquit piwi express profil well transpos element pirna coevolut like emerg transpos element silenc maintain genom stabil addit show co option evolut aros express shift venom gland play domin role venom turnov also highlight potenti import non venom gene coexpress venom gene venom evolut find great advanc current understand genom size evolut venom evolut genom resourc facilit compar genom studi insect futur
|
D014863
|
T204
|
36,302,844
|
relat individu cell divis event singl cell erk akt activ time cours biochem correl stochast singl cell fate elus even well studi mammalian cell cycl monitor singl cell dynam erk akt pathway critic cell cycl progress hub anti cancer drug target pair divis event singl cell use non transform mcfa epitheli line follow growth factor treatment cell divid erk akt activ signific higher within g time window h differ much smaller pre phase restrict point window tradit associ erk akt activ depend suggest unappreci role erk akt g simpl metric central tendenc time window associ subsequ cell divis fate erk activ strong associ divis fate akt activ suggest akt activ dynam may contribut less decis drive cell divis context also find erk akt activ less correl cell divid network reconstruct experi demonstr correl behavior like due crosstalk erk akt interact context contrast transform cell type overal find support role erk akt activ throughout cell cycl oppos restrict point suggest erk activ dynam may import akt activ dynam drive cell divis non transform context
|
D051057;D048049
|
T126;T116
|
36,302,843
|
growth base platform detect domain peptid interact cytoplasm mammalian cell develop method detect protein protein interact ppis live cell import therapeut drug screen various diseas includ infecti diseas recent develop method name sos local base interact screen soli design membran anchor sos fuse chimer protein whose ppi depend associ trigger membran local sos fuse chimer protein activ rasmapk pathway induc cell growth soli abl detect relat strong ppis sensit requir detect intracellular endogen ppis typic micromolar order dissoci constant k develop high sensit soli h soli could univers detect ppis lower affin order improv sensit h soli introduc heterodimer helper interact addit small molecul helper ligand could accommod associ two chimer protein regul sensit four type domain peptid interact known k valu employ examin versatil detect limit h soli consequ heterodim induc helper ligand dramat enhanc detect sensit lower detect limit ten micromolar order k thus h soli could platform detect diseas relat domain peptid interact drug discoveri screen
|
D010455;D025941
|
T063;T121;T116
|
36,302,842
|
develop japanes parent style scale examin valid reliabl parent essenti factor affect child develop therefor sever studi focus individu differ parent ie parent style howev exist use scale japan especi parent preschool children therefor new scale assess parent style japan base tradit theoret framework develop examin valid reliabl studi origin item construct parent preschool children complet item next item japanes parent style scale jpss select base factor analysi analys grade respons model jpss includ four factor warmth hostil permiss harsh control result show sub scale suffici conceptu valid intern consist studi criterion relat valid jpss examin total parent non particip studi complet jpss scale result show suffici criterion relat valid scale
|
D016487;D010290
|
T099;T102;T054
|
36,302,841
|
fate map reveal mix embryon origin uniqu development code mous forebrain septal neuron septum key structur core forebrain integr input relay inform brain area support cognit behaviour feed locomot under function rich divers neuron type intric complex wire across within septal region current littl understand septal neuron divers emerg develop use transgen mice express cre differ subset telencephal precursor explor origin three main neuron type septal complex gabaerg cholinerg glutamaterg neuron find septal neuron origin distinct neuroepitheli domain develop septum born differ embryon time point except gabaerg medial septal parvalbumin express popul generat outsid septum surround germin zone identifi transcript factor bsx express develop glutamaterg neuron popul embryon elimin bsx septum result reduct septal glutamaterg cell number consequ deficit locomot refin septal neuron divers need understand multipl role septal neuron contribut distinct behaviour
|
D009474;D010320
|
T123;T116;T025
|
36,302,840
|
novel anti tnf drug ozoralizumab rapid distribut inflam joint tissu mous model collagen induc arthriti clinic studi next generat anti tumor necrosi factor alpha tnf singl domain antibodi ozoralizumab show high clinic efficaci short subcutan inject elucid mechan under rapid onset effect ozoralizumab compar biodistribut kinet ozoralizumab adalimumab subcutan inject anim model arthriti alexa fluor label ozoralizumab adalimumab administ subcutan inject mgkg five week induct collagen induc arthriti cia anim arthriti model time cours chang fluoresc intens two compound paw serum evalu paw cia mice harvest four eight hour inject fluoresc microscopi biofluoresc imag reveal better distribut ozoralizumab joint tissu adalimumab earli four hour inject fluoresc microscopi reveal greater fluoresc intens ozoralizumab joint tissu adalimumab eight hour inject ozoralizumab show signific higher absorpt rate constant compar adalimumab result indic ozoralizumab enter system circul rapid distribut target tissu earlier higher level convent igg antibodi investig provid new insight mechan under rapid onset effect ozoralizumab clinic practic
|
D001169
|
T050
|
36,302,839
|
associ health asset valu subject well depress health manag strategi habit south korea studi aim measur monetari valu health asset base self report health status rate health asset valu hav evalu applic subject well health compet repres sampl south korea march april particip random sampl nationwid south korea administ questionnair includ self report rate health asset valu health status subject well index swbi patient health questionnair phq smart manag strategi health assess tool sat health habit multipl stepwis logist regress model adjust basic demograph variabl age sex region month incom level comorbid current hav independ associ posit swbi adjust odd ratio aor confid interv ci negat phq aor ci core aor ci prepar aor ci implement strategi score sat aor ci independ associ posit current hav health habit independ associ posit current hav aor rang hav approach offer new monetari valu health use make individu polit decis improv health reduc health inequ
|
D003863;D006304
|
T184;T080;T048
|
36,302,838
|
estim carbon stock wood product privat build compani wood product function carbon storag even harvest forest garner attent relev climat chang countermeasur progress effort toward climat chang mitig privat compani effect use wood product import measur howev methodolog account carbon stock wood product privat compani establish therefor studi investig method estim carbon stock wood product use wooden hous built privat enterpris target major compani japanes build industri result indic direct inventori method flux data method fdm applic estim carbon stock two method use data obtain mani build compani thus indic high versatil log normal weibul normal logist distribut descend order prove suitabl lifetim function wooden hous fdm half life year import continu acquir time seri data floor area newli built exist hous amount wood product use improv accuraci estim explor futur predict
|
D014934;D002244
|
T121;T196;T167
|
36,302,837
|
exploit bayesian approach deriv count marri women reproduct age across cameroon healthcar plan estim marri women reproduct age mwra need polici decis enhanc reproduct health given unavail cameroon studi aim deriv mwra count region divis data includ census women five demograph health survey women unit nation world popul prospect bayesian model use estim fertil rate net migrat final mwra count total mwra popul cameroon estim increas reflect percentag point p annual rise centr far north region host largest number project reach respect highest division level increas expect mfoundi p bnou p studi find show vari region division level estim trend mwra count set baselin determin demand programm famili plan scale relev resourc sub nation
|
D005193;D003268
|
T033;T055;T058;T054
|
36,302,835
|
subclin diagnosi cisplatin induc ototox biomark mous model cisplatin induc ototox use addit human sampl itmat biobank univers pennsylvania mous auditori brainstem respons abr inner ear histolog perilymph cisplatin sampl measur serum prestin via elisa perform human serum prestin level measur via elisa patient otolog issu cisplatin treatment compar match control serum prestin signific elev abr threshold shift mice expos cisplatin compar control mice prestin concentr also correl sever hear threshold shift mice extend rest post cisplatin treatment prestin return baselin level mice human prestin signific elev serum onset object hear loss correl sever hear damag indic prestin may function effect biomark cisplatin induc ototox human serum prestin level respond similar mice week ototox exposur decreas level prestin serum
|
D000081015;D034381;D000970
|
T121;T109;T033;T047;T046
|
36,302,834
|
assess land suitabl use soil indic base approach geomat environ studi aim develop new approach soil suitabl evalu base fact choos proper agricultur site requir good ergonom financi feasibl ahp includ select differ criteria use analysi categor accord use relat growth conditionsrequir select crop litholog soil physicochem topographi slope elev climat temperatur rainfal irrig water main criteria select studi studi indic area suitabl agricultur use take account qualiti water use maintain qualiti soil accord fao suitabl result n n total area result obtain new approach studi high high moder low low suitabl respect take account constraint unit fao locat low suitabl class total area valid crop product due restrict find studi help narrow area suitabl site may sustain use annual andor perenni crop propos approach high potenti applic assess land condit facilit optim plan agricultur use
|
D012987;D000383
|
T090;T167
|
36,302,833
|
new approach incorpor sea level rise hybrid done line shorelin model hybrid done line shorelin model typic appli finit volum approach simul sediment transport one line theori updat shorelin morpholog increas appli meso timescal year inform coastal manag one line theori assumpt constant closur depth prevent model consid effect sea level rise shorelin morpholog updat sea level rise endogen drive factor meso timescal coastal behaviour influenc closur depth effect wave climat paper present new hybrid done line approach enabl time vari closur depth respons annual variat wave climat solut mirror effect sea level rise coastal profil associ shorelin evolut new hybrid approach appli hindcast meso timescal shorelin evolut sandi coastal system compar tradit hybrid done line approach result show tradit hybrid approach give accur predict wherea new hybrid approach overpredict shorelin eros howev overpredict attribut net closur depth overestim attribut give confid shorelin respons time vari closur depth specifi within expect sinc closur depth overestim increas offshor sediment transport shorelin model therefor like enabl time vari closur depth hybrid done line model may improv meso timescal shorelin predict sea level rise closur depth accur prescrib time
|
D000080763;D057231
|
T070;T067
|
36,302,832
|
comparison definit bronchopulmonari dysplasia reflect long term outcom extrem preterm infant survivor neonat bronchopulmonari dysplasia bpd persist respiratori neurodevelopment growth impair first year life later childhood repres emerg burden health system therefor increas need new definit grade system bpd predict long term outcom high risk infant need time proper intervent improv outcom compar new definit bpd nation institut child health human develop nichd neonat research network nrn origin nichd definit year age use nationwid cohort extrem preterm infant new definit sever grade clear relat respiratori neurodevelopment growth impair year age month correct age ca wherea origin nichd definit furthermor negat effect bpd growth amelior year age compar month ca howev negat effect bpd neonat respiratori system neurodevelop persist year age new definit adopt identifi high risk infant improv long term outcom exact diagnosi bpd sever classif
|
D001997
|
T047
|
36,302,831
|
common variabl oestrogen relat gene pancreat ductal adenocarcinoma risk women incid pancreat ductal adenocarcinoma pdac differ among male femal dispar fulli explain differ term exposur known risk factor therefor lower incid women could attribut sex specif hormon two phase associ studi conduct femal subject pdac case control assess effect risk develop pdac singl nucleotid polymorph snps gene involv oestrogen pregnenolon biosynthesi oestrogen mediat signal discoveri phase polymorph show statist signific associ p replic none find valid addit gene base analysi perform select gene four gene nra med ncoa runx associ pdac risk nra show associ p bonferroni correct threshold statist signific conclus despit differ incid male femal studi identifi effect common polymorph oestrogen pregnenolon pathway relat pdac suscept howev valid previous report associ nra gene variant pdac risk
|
D000230;D021441;D010190
|
T191
|
36,302,830
|
bioinformat analysi purpos design novel multi epitop dna vaccin leishmania major leishmaniasi one main infecti diseas worldwid midst differ form diseas cutan leishmania cl highest incid world mani trial vaccin develop purpos generat long term cell mediat immun leishmania l major multi epitop dna vaccin high efficaci lmajor aim studi design new multi epitop dna vaccin order effect control upon infecti diseas immun bioinformat lmajor antigen gp lack tsa lmstiand kmp select design multi epitop dna vaccin initi structur dna vaccin design benefit gen bank websit inform epitop mhc antigen predict immun epitop databas iedb select epitop use make vaccin construct along linker new multi epitop vaccin includ nucleic acid design insert bamh hindiii restrict site pcdna mammalian express vector epitop among chosen antigen select two server iedb antigen high stabil high antigen power physicochem featur vaccin measur protparam server structur thermost hydrophil suitabl model studi anim human phase design vaccin expect effect candid develop cl vaccin howev effect vaccin also evalu vivo model
|
D019444;D018320
|
T129;T121;T204;T114
|
36,302,829
|
lncrna anril mediat mir b pspr axi involv progress urem cardiomyopathi activ cell studi aim explor regulatori role lncrna anrilmir b pspr uc uc mous model establish th nephrectomi detect bodi weight serum level renal function inflammatori factor biochem analyzerelisa cardiac paramet echocardiographi masson stain show patholog chang fibrosi myocardi nephridi tissu express anril mir b p spr detect qrt pcr western blotimmunofluoresc cell activ analyz flow cytometri anrilspr regul mir b p regul uc mice anril silenc regul mir b p regul spr target mir b p anril silenc increas bodi weight recov renal function decreas blood urea nitrogen bun serum creatinin scr cardiac function decreas left ventricular end diastol diamet lvedd lv end systol diamet lvesd lv systol anterior wall thick lvaw lv end diastol anterior wall thick lvawd myocardi perform index mpi isovolum relax time ivrt increas lv eject fraction lvef lvefmpi fraction shorten fs e wave ea inhibit inflamm decreas interferon ifn interleukin il il tumor necrosi factor tnf reliev patholog injuri fibrosi anril silenc also recov viabil inhibit inflamm activ cell vitro inhibit cell activ uc mice vivo addit mir b p overexpress exhibit effect anril silenc uc anril silenc inhibit cell activ regul mir b pspr contribut remiss uc
|
D009202;D035683;D062085;D013601;D000081025
|
T123;T116;T025;T192;T114;T047
|
36,302,828
|
evalu machin learn algorithm predict direct act antivir treatment failur among patient chronic hepat c infect despit avail efficaci direct act antivir daa therapi number peopl infect hepat c virus hcv continu rise hcv remain lead caus liver relat morbid liver transplant mortal develop valid machin learn ml algorithm predict daa treatment failur use hcv target registri adult initi oral daa treatment develop elast net en random forest rf gradient boost machin gbm feedforward neural network fnn ml algorithm model perform compar multivari logist regress mlr assess c statist predict evalu metric among hcv infect adult patient experienc daa treatment failur ml model perform similar predict daa treatment failur c statist ci en rf gbm fnn outperform mlr c statist ci en use fewest predictor n youden index en sensit specif nine patient need evalu identifi daa treatment failur treatment failur classifi top three risk decil subgroup en identifi predictor includ male sex treatment week treatment discontinu due advers event albumin level gdl advanc liver diseas use tobacco alcohol vitamin address modifi factor daa treatment failur may reduc burden retreat machin learn algorithm potenti inform public health polici regard curat treatment hcv
|
D019698;D006526
|
T047
|
36,302,826
|
identifi accur link predictor base assort complex network link predict algorithm complex network social network biolog network drug drug interact communic network assign score predict potenti link two node link predict lp enabl research learn unknown new well futur interact among entiti model complex network addit measur like degre distribut cluster coeffici central etc anoth metric character structur properti network assort measur tendenc node connect similar node paper explor metric effect predict link base assort profil complex network end first propos approach generat network vari assort level util three set link predict model combin similar neighborhood preferenti attach carri experi studi lp accuraci measur term area precis recal curv link predictor individu combin baselin measur analysi show link predict model explor larg neighborhood around node interest ch l ch l perform consist assort well disassort network common neighbor base local measur effect assort network propos combin common neighbor node degre good choic lp metric disassort network discuss analysi help achiev best parameter combin link predict model signific context link predict incomplet social biolog network data
|
D000465
|
T170
|
36,302,824
|
educ qualiti may closer correl cardiometabol health educ attain educ qualiti may closer correl physic health common use measur educ attain eg year school examin whether wide use perform base measur educ qualiti close associ cardiometabol health educ attain highest level educ complet whether perceiv control smaller sampl execut function sampl health literaci smaller sampl link educ qualiti cardiometabol health two sampl n n collect differ region us educ qualiti associ cardiometabol health beyond educ attain demograph factor age ethnoraci categori sex fluid intellig counter expect neither perceiv control execut function health literaci signific mediat associ educ qualiti cardiometabol health find add grow literatur suggest current operation construct educ like underestim associ educ multipl form health extent educ program may overlook base appar size associ outcom action may prematur
|
D000076363;D002318
|
T047;T080
|
36,302,823
|
sar cov air surfac contamin residenti set sar cov transmiss occur main indoor virus laden airborn particl although presenc infect sar cov aerosol acknowledg under circumst occurr still investig contamin domiciliari environ isol sar cov infect patient respect room individu hous nurs home investig collect surfac air sampl environ surfac contamin detect differ context high low touch surfac determin presenc virus particl air two sampl methodolog use air deposit sampl posit deposit sampl found sampl locat patient height sar cov rna detect impact air sampl within size fraction surfac sampl render highest posit rate persist longer period presenc aerosol sar cov rna occur main deposit sampl closer symptom onset evalu infect select posit sampl sar cov viabil assay perform studi abl valid virus viabil present result confirm presenc aerosol sar cov rna indoor compart occupi covid patient mild symptom absenc aerosol generat clinic procedur
|
D000086402;D000086382
|
T005;T067;T047
|
36,302,822
|
track footprint artifici natur select signatur breed non breed cat stray non breed cat stray repres largest heterogen cat popul subject natur select popul siames siam orient shorthair osh breed develop intens artifici select aesthet trait run homozygos roh demograph measur use tool discov chromosom region recent select character genet divers domest cat popul achiev genotyp stray household non breed cat household illumina felin k snp beadchip compar siam osh decay valu squar correl coeffici r stray household osh siam correspond mean marker distanc kb kb kb kb respect effect popul size n e decreas current generat stray household osh siam recent generat increas inbreed per generat f reach maximum valu stray household osh siam respect genom inbreed coeffici f roh base roh calcul three length categori f roh f roh f roh stray f roh f roh household f roh f roh osh f roh f roh siam identifi nine uniqu select region stray genom wide analys region reduc heterozygos base f st statist gene region previous associ reproduct bubb motorneurolog behavior gphn gabrb cold induc thermogenesi dio tshr immun system develop tshr viral carcinogenesi gtfa host immun respons bacteria virus chemoattract cancer cell plcb bahd tigar lifespan age bubb fgf addit identifi twelv uniqu select region osh contain candid gene wide rang coat color pattern adamt kitlg tyr tyro mitf regul gpnmb fgf rab well congenit heart defect pded pkp gastrointestin disord nlgn aldhb gene stray repres uniqu select event indic least part natur select environment adapt resist infecti diseas subject futur research stray cat repres import genet resourc potenti becom research model diseas resist longev recommend preserv semen neuter
|
D055106;D020641
|
T063;T086
|
36,302,820
|
actual condit person object contact propos prevent measur covid pandem studi focus human contact behavior object discuss countermeasur covid pandem across locat type reduc contact object disinfect item implement relat low cost creat protocol organ object subject went outsid day decemb tokyo kanagawa japan survey particip touch object total common object door chair basket elev equip cash one way analysi varianc scheff multipl comparison test show supermarket lowest mean median valu despit highest number user contact object object type convers valu hotel highest signific higher place exclud amus park workplac school univers furthermor long tail frequenc distribut number object suggest object touch mani individu limit thus import determin object priorit disinfect locat data protocol could inform infect countermeasur proper address contact realiti pertain peopl behavior object
|
D000086382
|
T047;T067
|
36,302,819
|
experiment increas snow depth affect high arctic microarthropod inconsist two consecut winter climat chang induc alter winter condit may affect decompos organ control vast carbon store northern soil soil microarthropod particular abund decompos arctic ecosystem studi whether increas snow depth affect microarthropod effect consist two consecut winter sampl collembola soil mite snow accumul experi svalbard earli summer use soil microclimat data explor aspect winter climat microarthropod sensit communiti densiti differ substanti year increas snow depth inconsist effect deeper snow hard affect microarthropod decreas densiti alter relat abund microarthropod collembola speci milder winter although increas snow depth increas soil temperatur c throughout snow cover period best microclimat predictor microarthropod densiti chang spring soil temperatur snowmelt day studi show extrapol observ decompos respons alter winter climat condit futur scenario avoid communiti sampl singl occas sinc effect longer term gradual chang winter climat may obscur inter annual weather variabl natur variabl popul size
|
D012914;D017753
|
T070;T082
|
36,302,818
|
featur generat contribut comparison electron fraud detect modern money transfer servic conveni attract fraudul actor run scam victim deceiv transfer fund fraudul account machin learn model broad appli due poor fraud detect perform tradit rule base approach learn direct raw transact data impract due high dimension natur studi construct featur instead extract pattern raw transact data past literatur categor featur recenc frequenc monetari anomali detect featur use various machin learn algorithm examin perform featur four categori real transact data compar perform featur generat guidelin base statist perspect characterist non fraudul account result show except monetari categori featur categori use literatur perform poor regardless machin learn algorithm use anomali detect featur perform worst find even statist featur generat base financi knowledg yield limit perform real transact dataset atyp detect characterist normal account improv abil distinguish fraudul account henc improv overal detect result outperform exist method
|
D005607;D005376
|
T081;T054;T057
|
36,302,817
|
genet causal infer amblyopia perinat factor amblyopia common visual disord caus signific vision problem global non ocular risk factor amblyopia close relat intrauterin environ strong influenc parent origin effect parent origin perinat factor may direct causal infer amblyopia develop therefor investig causal associ perinat factor amblyopia risk use one sampl mendelian random mr data uk biobank cohort data ukbb four distinct mr method employ analyz associ three perinat factor birth weight bw matern smoke breastfeed amblyopia risk base summari statist genom wide associ studi european popul invers varianc weight method show invers causal associ bw amblyopia risk odd ratio ci p matern smoke breastfeed causal associ amblyopia risk find provid possibl evid signific genet causal associ low bw increas amblyopia risk evid may highlight potenti bw predict factor visual maldevelop need care manag amblyopia risk patient low bw
|
D055106;D000550
|
T063;T047
|
36,302,816
|
aphid inspir metaheurist optim algorithm applic engin biolog inspir metaheurist algorithm obtain optim solut simul live habit behavior characterist creatur natur wide use mani field new bio inspir algorithm aphid optim algorithm aoa propos paper algorithm simul forag process aphid wing includ generat wing aphid flight mood attack mood concurr correspond optim model present accord phase phase flight mood accord comprehens influenc energi airflow individu adapt choos flight mode migrat phase attack mood individu use sens smell vision locat food sourc movement experi benchmark test function two classic engin design problem indic desir aoa effici metaheurist algorithm
|
D001042
|
T204
|
36,302,815
|
autom generat adversari network base synthet data augment maxim diagnost perform paranas imag thus far report specif rule systemat determin appropri augment sampl size optim model perform conduct data augment paper report feasibl synthet data augment use generat adversari network gan propos autom pipelin find optim multipl data augment achiev best deep learn base diagnost perform limit dataset use water view radiograph patient diagnos chronic sinus demonstr method develop herein demonstr approach produc signific better diagnost perform paramet model train use convent data augment deep learn method propos studi could implement assist radiologist improv diagnosi research industri worker could overcom lack train data employ propos autom pipelin approach gan base synthet data augment anticip provid new mean overcom shortag graphic data algorithm train
|
D000077321
|
T066
|
36,302,814
|
syndem intim partner violenc among women hiv endem south africa geospati analysi nation repres data despit improv lower hiv incid hiv relat challeng intim partner violenc ipv remain unaccept high among women south africa decad research activist point complex intertwin realiti substanc abus violenc aid sava syndem endang women howev recent systemat reviewmeta analysi evid point inconclus associ ipv alcohol use furthermor much evid often non popul base focus co occurr rather synergist sava interact studi use latest data south africa demograph health survey sa dhs identifi geograph synergist cluster ipv associ hiv substanc abus south africa measur popul level interact among factor sa dhs nation repres sampl includ wide rang data health social challeng household geo locat women particip domest violenc modul first geograph ipv harm alcohol use substanc abus measur avail sa dhs hiv cluster identifi use kulldorff spatial scan statist satscan second synergist interact relat recent ipv ie recent physic sexual emot violenc last month harm alcohol use hiv challeng measur use reri relat excess risk due interact ap attribut proport synergi index result spatial identifi geograph physic ipv syndem interact part eastern capefre state provinc reri ci ap ci ci form ipv although ipv base decad old concept sava syndem less commonwidespread expect nation scale popul base data identifi popul level physic violenc syndem occur south africa studi highlight need priorit public health respons target vulner popul resid high risk area syndem mechan link synergist epidem women face south africa
|
D000163;D000437;D015658;D000066511;D019966
|
T033;T047;T053;T048
|
36,302,813
|
effect differ virtual realiti technolog driven dual task paradigm postur saccad eye movement healthi older adult postur sway eye movement potenti biomark dementia screen assess two movement comprehens could improv understand complic syndrom accur screen purpos research evalu effect comprehens assess healthi older adult oa use novel concurr comprehens assess system consist stabilomet virtual realiti headset healthi oa year recruit use cross section studi design studi investig effect various dual task paradigm integr task visuospati memori vm spatial orient visual challeng postur saccad dual task paradigm vm affect saccad eye movement signific two high intens test anti saccad vm task pro saccad task also influenc postur sway signific strong associ seen postur sway eye movement condit two movement theoret share common neural pathway brain vice versa studi suggest assess postur saccad integr task comprehens simultan could use explain differ function brain result warrant cross section studi oa without dementia explor differ group
|
D000076142;D003704
|
T066;T048
|
36,302,811
|
genesi fecal floatat causal link gut microbi colon mice origin fecal floatat phenomenon remain poor understood follow serendipit discoveri differ buoyanc fece germ free convent mice character microbi physic properti fece germ free gut colon convent convention mice gut colon associ differ assess fece use dna bacteri pcr scan electron microscopi fac thermogravimetri pycnometri base differ buoyanc fece develop lev fimo test lift distinguish sink fece sinker germ free mice float fece floater gut colon mice simultan track microbiota densiti gut colon kinet fecal transplant mice provid first direct evid causal relationship gut microbi colon fecal floatat rare discord lift microbiota densiti indic enrich gasogen gut colon may necessari fecal floatat final fecal metagenom analysi floater convent syngen fecal transplant mice identifi colon gasogen bacteri speci includ high preval b ovatus anaerob commens bacteria link flatul intestin bowel diseas find report improv understand food microbi biotransform gut microbi regul fecal floatat human health diseas
|
D000069196
|
T007;T001
|
36,302,810
|
eeg base analysi various sensori stimul effect reduc visual induc motion sick virtual realiti use virtual realiti vr frequent accompani motion sick approach prevent yet well establish explor effect synchron present sound motion visual induc motion sick vim order reduc vim total particip bicycl ride min without sound motion synchron present head mount display result vim score measur fast motion sick scale simul sick questionnair signific lower particip experienc ride scene sound motion experienc ride scene sound motion neither furthermor analysi eeg signal show higher vim signific increas alpha theta wave pariet occipit lobe therefor demonstr simultan present sound motion close associ synchron visual flow speed effect reduc vim experienc simul bicycl ride vr environ
|
D009041;D000076142
|
T047;T066
|
36,302,809
|
ecolog evolutionari trend bodi size pristimanti frog world divers vertebr genus bodi size key organism trait howev environment evolutionari factor drive bodi size pattern interspecif level remain unclear explor relationship phenotyp environ use neotrop frog pristimanti world divers vertebr genus analyz whether group follow rensch rule trend sexual size dimorph ssd increas size male larger sex b whether environment constraint influenc bodi size variat c rate bodi size evolut vari time analys base two inform sourc first one includ bodi size speci known speci genus second one incorpor molecular phylogenet inform speci result show pristimanti speci exhibit mark ssd follow rensch rule found model best explain bodi size male femal ssd contain environment variat temperatur precipit elev predictor turn bodi size evolv toward optimum deceler rate evolut differenti larg pristimanti clade
|
D012727;D001001
|
T011;T032
|
36,302,808
|
util ex vivo tissu model studi skin regener follow microneedl stimuli microneedl popular skin resurfac rejuven procedur order develop better adjunct product consum scientif need establish greater understand mechan microneedl stimul regener within skin purpos studi develop physiolog relev ex vivo tissu model close mimic actual microneedl procedur elucid mechan action studi human ex vivo skin subject microneedl treatment cultur day histolog analysi demonstr ex vivo skin abl heal microneedl injuri throughout cultur period microneedl treatment stimul prolifer barrier renew skin procedur also increas level inflammatori cytokin angiogen growth factor dynam time depend fashion tissu demonstr hallmark sign epiderm regener morpholog molecular chang treatment one first work date util microneedl ex vivo skin demonstr regen behavior model recapitul main featur microneedl treatment enabl evalu futur cosmet activ ingredi use conjunct microneedl
|
D003357
|
T061
|
36,302,807
|
dementia risk visual impair chines older adult previous identifi visual impair increas risk incid dementia bi direct vision cognit associ subsequ propos studi specif examin longitudin associ dementia incid clinic defin visual impair territori wide communiti cohort studi visual unimpair older adult examin visual acuiti annual year test dementia baselin independ associ higher risk incid visual impair logmar better eye despit best correct equival moder visual impair accord world health organ definit end year total particip develop visual impair howev find baselin dementia associ higher risk incid visual impair control baselin visual acuiti cataract glaucoma diabet hypertens hypercholesterolemia heart diseas stroke parkinson diseas depress hear physic impair physic intellectu social activ diet smoke age sex educ level socioeconom status among differ covari baselin visual acuiti appear import dementia contribut develop visual impair present find highlight need evalu whether dementia inde risk factor visual impair
|
D015354;D003704
|
T047;T048
|
36,302,806
|
applic dris banana base accuraci nutrit diagnos nitrogen potassium dris diagnosi recommend integr system tool use interpret leaf analys valu balanc nutrient import fact better assess nutrit status banana plant use depend abil identifi nutrient limit product order correct possibl nutrit imbal lack research crop includ banana assess accuraci diagnos worri global implic end studi evalu dris norm banana cultiv ecuador use accuraci measur nutrit diagnosi verifi capac dris detect true nutrit status base plant respons databas creat contain result refer product leaf content n p k ca mg cl fe mn cu b zn banana tree field experi evalu dose nitrogen potassium accuraci dris norm n k result show dris banana produc ecuador depend nutrient variabl accord crop nutrit status dris norm diagnosi n k result accept accuraci identifi defici toxic respect indic need adjust standard later use field thus need research aim adopt calibr dris diagnost norm assess nutrit status banana ecuador
|
D028521
|
T168;T002
|
36,302,805
|
cross section studi cholinerg urticaria subtyp bronchial hyperrespons cholinerg urticaria cholu classifi sever subtyp convent sweat allergi type cholu convent sat cholu cholu palpebr angioedema cholu pa cholu acquir anhidrosi andor hypohidrosi cholu anhd includ sat base pathogenesi studi differ preval bronchial asthma among subtyp analyz bronchial respons use methacholin dose indic min respiratori symptom exhal nitric oxid feno median log min interquartil rang patient convent sat cholu n cholu pa n cholu anhd n respect p respiratori symptom less frequent observ cholu anhd convent sat cholu cholu pa feno patient convent sat cholu cholu pa cholu anhd ppb respect p nine convent sat cholu patient half cholu pa patient requir treatment asthma log min tend lower patient sat cholu cholu anhd cholu pa might associ asthma
|
D016535;D014581;D001249
|
T047
|
36,302,804
|
evid earli toarcian carbon isotop excurs cie shallow marin siliciclast red bed arabia toarcian ocean anox event oae correspond carbon isotop excurs cie report wide across tethyan region global arabia base ammonit date time window oae coincid deposit reddish siliciclast unit marrat format howev evid oaeci ever report arabia red bed previous interpret continent deposit recent red bed recogn shallow marin deposit open opportun assess occurr express oae cie arabia studi multiproxi geochem character perform toarcian marrat format infer chemistri paleowat column identifi interv possibl oaeci arabia low concentr redox sensit element mo u v cr may indic shallow oxic marin set coupl negat c organ excurs appar increas chemic weather suggest deposit marrat red bed coincid develop cie possibl time equival oae global origin redden interpret occur middl marrat deposit due stabil unstabl hydrous iron oxid hematit oxic marin condit propos model indic possibl develop sourc rock deep anox environ counterpart oae may express sinc studi document first record cie discuss origin shallow marin siliciclast red bed arabian plate signific implic overal understand cie global hydrocarbon explor realize potenti new sourc rock associ oae toarcian time interv
|
D000860;D019015
|
T184;T070;T033;T068;T046
|
36,302,803
|
impact kidney function kidney volum intracrani aneurysm patient autosom domin polycyst kidney diseas present person famili histori intracrani aneurysmsubarachnoid hemorrhag iasah establish risk factor ia autosom domin polycyst kidney diseas adpkd studi aim verifi associ kidney functionvolum ia patient adpkd studi includ patient adpkd baselin ia screen median age estim glomerular filtrat rate year mlmin respect famili iasah histori confirm patient patient hypertens ia point preval clinic follow patient year de novo ia detect patient patient year ia period preval median age year multivari logist regress demonstr total kidney volum tkv ml odd ratio height adjust tkv ml mayo imag classif class e chronic kidney diseas stage signific associ ia format ia patient adpkd may associ general risk factor ia also declin kidney function increas kv kidney diseas progress may contribut effect ia screen treatment plan patient adpkd
|
D016891;D002532;D013345
|
T019;T047;T046;T190
|
36,302,802
|
exercis serum regul uric acid transport normal rat kidney cell hyperuricemia hua refer physiolog condit high serum uric acid sua level bodi may caus increas risk sever chronic diseas kidney impair uric acid ua metabol import reason hua studi test hypothesi circul factor produc exercis regul express abcc abcg urat glut normal rat kidney normal rat kidney cell nrk e relationship nf b nrf nrk e cell separ cultur serum healthi sd rat exercis con healthi sd rat aerob treadmil exercis week cell cultur serum rat aerob treadmil exercis week separ without nrf inhibitor exe nrf inhibitor exe ml sua level rat test use dri chemic assay xanthin oxidas xod activ serum liver test use enzym colorimetri assay protein express kidney nrk e cell test use western blot ua level upper lower chamber test colorimetri assay aerob exercis reduc sua level rat signific affect liver xanthin oxidas also increas express ua transport kidney nrk e cell increas cell abil ua excret nrf inhibit nf b abcg increas express abcc urat glut decreas conclus studi suggest week aerob treadmil exercis intervent may help improv excret ua renal cell suggest long term aerob exercis may mean prevent hyperuricemia
|
D033461;D027361
|
T123;T047;T116
|
36,302,801
|
clinic associ trace element tear dri eye metric trace element exposur propos play role pathogenesi system diseas emerg studi suggest trace metal exposur may contribut dri eye diseas studi primarili aim investig associ trace metal exposur tear sampl presenc dri eye metric shipyard industri overal elig particip shipyard industri includ cross section studi paramet identifi dri eye symptom includ osdi speed nibut ocular surfac condit tear meniscus height eye blink meibomian gland area perform sbm sistemi ocular surfac analyz concentr tear trace element detect induct coupl plasma mass spectroscopi icp ms associ tear trace element dri eye paramet investig use regress model particip exposur group signific higher level tear pb control group exposur group tear pb signific associ increas speed osdi score beta coeffici ci ci respect decreas lower upper meibomian gland area beta coeffici respect tear trace element exposur consid impact appear dri eye metric improv occup environ monitor ocular surfac health may benefit worker exposur trace element
|
D014131;D015352;D022125
|
T123;T121;T184;T196;T037;T047
|
36,302,800
|
neuromedin u defici rat lose bodi weight food intak studi genet modifi mice establish essenti role endogen neuromedin u nmu anorexigen function metabol regul indic nmu expect potenti target anti obes agent howev central administr experi rat inconsist result obtain essenti role nmu energi metabol rat remain unclear studi aim elucid role endogen nmu rat generat nmu knockout ko rat unexpect show differ bodi weight adipos circul metabol marker bodi temperatur locomotor activ food consumpt normal high fat chow feed furthermor unlik report mice express nmu nmu receptor type nmur mrna hard detect rat hypothalam nuclei regul feed energi metabol includ arcuat nucleus paraventricular nucleus nmu express par tuberali nmur express ependym cell layer third ventricl result indic speci specif express pattern nmu nmur may allow nmu distinct function across speci endogen nmu function anorexigen hormon rat
|
D009479;D036361
|
T125;T123;T116
|
36,302,799
|
atg relat signatur predict prognosi therapeut option hepatocellular carcinoma autophagi play critic role tumor pathogenesi howev autophagi relat signatur hepatocellular carcinoma hcc reveal yet quantifi level various cancer hallmark identifi atg major risk factor overal surviv hcc robust atg relat gene signatur at prognosi construct use combin bioinformat statist approach addit genet immunolog properti measur at high at low group at signatur associ shorten overal surviv hcc patient independ clinicopatholog characterist at status defin inflam yet exhaust tumor microenviron activ exhaust cd cd cell strong associ at at signatur predict drug resist immunotherapi thus combin target therapi immunotherapi might suitabl at high patient work shed light function atg relat gene hcc reveal at signatur may use prognost biomark differenti molecular immunolog featur predict probabl respons therapi
|
D006528;D008113
|
T191
|
36,302,798
|
galerkin finit element analysi magnet radiat reactiv walter b nanofluid motil microorgan riga plate order understand characterist bio convect move microorgan flow magnet walter b nano liquid develop model employ riga plate stretchi sheet buongiorno phenomenon likewis employ describ nano liquid motion walter b fluid expend correspond transform partial differenti equat pde control system transform ordinari differenti equat ode control system comsol program use generat mathemat answer non linear equat employ galerkin finit element strategi g fem util logic graphic metric temperatur veloc microb analysi studi various estim well known physic featur taken account calcul nanoparticl concentr demonstr model comput direct relat temperatur field current biot number paramet walter b fluid temperatur field increas increas approxim current biot number paramet walter b fluid
|
D008962;D018481
|
T062;T170;T070
|
36,302,797
|
predict autist tendenc month age via markerless video analysi spontan bodi movement month old infant earli intervent consid core treatment strategi autism spectrum disord asd thus signific clinic import establish screen tool earli detect asd infant achiev goal longitudin design analyz spontan bodili movement month old infant general popul assess asd like behavior month age total movement featur calcul video record bodili movement infant month age risk asd assess month age modifi checklist autism toddlerhood wide use screen questionnair infant high risk asd month age exhibit less rhythmic weaker bodili movement pattern month age low risk infant observ bodili movement pattern submit machin learn base analysi linear non linear classifi success predict asd like behavior month age base bodili movement pattern month age level accept practic use studi analyz relationship spontan bodili movement month age asd risk month age experiment result suggest util propos method earli screen infant risk asd reveal sign asd risk could detect earli month birth focus infant spontan bodili movement
|
D001321;D000067877
|
T048
|
36,302,796
|
natur cycl south pacif gyre strength southern annular mode south pacif gyre spg play vital role regul southern hemispher climat ecosystem spg intensifi sinc twentieth centuri due chang larg scale wind forc chang result variabl southern annular mode sam caus warm along eastern spg affect local ecosystem howev understand spg variabl timescal greater sever decad poor due limit observ marin sediment core tradit use determin recent ocean trend anomal rare captur centenni variabl southwest pacif limit understand spg variabl captur centenni spg dynam use novel high resolut paleocircul archiv radiocarbon reservoir age r local reservoir correct r spg deep sea black coral find black coral r r correl sam reconstruct cal bp cal bp propos correl indic vari transport well ventil subtrop water result spg sam interact reconstruct sever spin cycl reminisc recent gyre intensif attribut anthropogen caus impli gyre strength sam show natur co variabl anthropogen timescal factor futur climat project
|
D017753;D037421
|
T070;T204;T082
|
36,302,795
|
east asian heatwav driven arctic siberian warm studi investig contribut factor east asian heatwav eahw link arctic siberian plain asp past year eahw main affect two time scale variabl long term extern forc interannu variabl extern forc eahw attribut increas global warm trend interannu variabl relat circumglob teleconnect cgt asp teleconnect pattern addit cgt rossbi wave energi origin asp propag east asia upper tropospher amplifi eahw stationari high pressur asp generat vortic advect upper tropospher enhanc surfac radiat heat evapor asp surfac increas specif humid temperatur amplifi thermal high pressur via posit water vapor feedback thermal high pressur amplifi land atmospher interact asp peak summer season lead eahw propag stationari rossbi wave energi result indic enhanc understand asp teleconnect improv forecast eahw sub season time scale also futur project global climat model
|
D057232;D001272
|
T070;T069
|
36,302,794
|
influenc puls repetit rate acoust output ballist pressur wave devic ballist devic generat radial pressur wave use treatment differ therapeut indic order assess effect devic interpret transfer result clinic trial import know acoust output paper two ballist devic reproduc differ clinic relev set investig vitro test setup pressur curv measur water differ intens level puls repetit rate sound field paramet peak pressur posit puls intens integr calcul pressur curv addit surfac veloc applic determin air use vibromet devic show good puls puls reproduc peak maximum pressur posit puls intens integr decreas slight p max pii compar hz hz one devic drop sharpli p max pii devic compar hz hz effect observ vibromet measur result show increas puls repetit rate stabil paramet vari differ devic henc sound field paramet compar transfer set one devic anoth
|
D000162;D013016
|
T070
|
36,302,793
|
morpholog divers molecular phylogeni five paramecium bursaria alveolata ciliophora oligohymenophorea syngen identif green algal endosymbiont paramecium bursaria mixotroph ciliat speci common stagnant slow flow nutrient rich water usual found live symbiosi zoochlorella green alga genera chlorella micractinium investig p bursaria isol around world alreadi extens studi various laboratori whose morpholog genet ident yet complet clarifi phylogenet analys ssu rdna sequenc reveal five high support lineag correspond syngen like biolog speci assign syngen r r could also distinguish uniqu synapomorphi secondari structur ssu consid synapomorphi could clear assign exist genbank entri p bursaria specif syngen addit discov synapomorphi amino acid coi gene identif syngen use metadata entri syngen show worldwid distribut howev syngen r r found europ morpholog syngen show signific deviat investig strain either chlorella variabili chlorella vulgari micractinium conductrix endosymbiont
|
D010247;D016802;D056893;D048408;D016798;D000460
|
T002;T204
|
36,302,792
|
sarcomer dynam reveal myofila integr fret base biosensor live skelet muscl fiber sarcomer function unit skelet muscl essenti proper contract numer acquir inherit myopathi impact sarcomer function caus clinic signific diseas mechanist investig sarcomer activ challeng undertak context intact live skelet muscl fiber real time physiolog twitch contract skelet muscl specif intramolecular fret base biosensor design engin fast skelet muscl troponin c tnc investig dynam sarcomer activ transgen anim tnc biosensor incorpor skelet muscl fiber sarcomer stoichiometr replac endogen tnc alter normal skelet muscl contractil form function intact singl adult skelet muscl fiber real time twitch contractil data show tnc biosensor transient preced peak amplitud contract import physiolog temperatur inactiv tnc biosensor transient decay signific slowli ca transient contract uncoupl tnc biosensor transient ca transient indic biosensor function ca transient report rather report dynam sarcomer activ inactiv turn due ensembl effect multipl activ ligand within myofila togeth find provid foundat implement new biosensor futur physiolog studi investig mechan activ skelet muscl sarcomer health diseas
|
D012518;D015374
|
T026;T059;T075
|
36,302,791
|
tempor chang plant communiti relationship soil salin microtopographi caspian sea coast gradual dri saltwat bodi creat habitat characteris chang environment condit might avail subset plant local flora use two terrestri area differ age caspian coast chronosequ investig factor includ microtopographi ground water level soil salin drive plant communiti success retreat sea veget two key site appear retreat caspian sea year ago compar term evolutionari ecolog trait plant edaph condit veget differ two site harsher edaph condit xerophyt elder site speci grew earli site dispers across phylogenet tree loss late site random speci grew late site phylogenet cluster level microtopographi elev spot dens popul earli site lower spot late site situat opposit main edaph factor drive differ veget composit two site like salin moistur environment chang differ plant trait import surviv appear communiti de novo microtopographi import form plant communiti role chang time
|
D012987;D054712
|
T034;T167
|
36,302,789
|
gallbladd cancer gallbladd cancer gbc common cancer biliari tract character poor prognosi diagnos advanc stage owe aggress behaviour limit therapeut option earli detect curabl stage remain challeng patient rare exhibit symptom inde gbcs discov incident follow cholecystectomi symptomat gallbladd stone long stand chronic inflamm import driver gbc regardless lithias non lithias origin advanc omic technolog provid deeper understand gbc pathogenesi uncov mechan associ inflamm driven tumour initi progress surgic resect treatment curat intent gbc case suitabl resect adjuv therapi low respons rate sever unmet clinic need requir address improv gbc manag includ discoveri valid reliabl biomark screen therapi select prognosi standard preneoplast neoplast lesion nomenclatur well surgic specimen process sampl provid reproduc compar research data provid basi identifi implement earli detect strategi improv drug discoveri advanc understand next generat sequenc multidisciplinari care gbc neoadjuv adjuv strategi novel system therapi includ chemotherapi immunotherapi gradual chang treatment paradigm prognosi recalcitr cancer
|
D005706;D042882
|
T191;T031
|
36,302,788
|
magneto hydrotherm tripl convect w shape porous caviti contain oxytact bacteria bioconvect heat mass transport phenomena recent subject interest divers field applic pertain motion fluid thermophys properti transport process system involv tripl convect phenomena irregular geometri boundari condit constitut complex phenomenon work aim explor mix thermo bioconvect magnet suscept fluid contain copper nanoparticl oxytact bacteria novel w shape porous caviti buoyant convent generat due isotherm heat wavi bottom wall wherea mix convect induc due shear motion top cool slide wall furthermor bioconvect induc due manifest oxytact bacteria organ inclin sidewal insul geometri pack water base cu nanoparticl mix porous structur subject magnet field act horizont complex transport equat transform nondimension form comput use finit volum base develop code coupl tripl convect flow physic explor wide rang involv control paramet could provid help insight system design proper oper shape geometri consid one import paramet control heat mass transport phenomena general influenc amplitud compar wavi number undul magnitud heat nu mass sh transfer rate w shape caviti high compar convent squar trapezoid shape caviti output analysi could help design model devic oper nanotechnolog base bioconvect microbi fuel cell other
|
D018481;D036103
|
T090;T070
|
36,302,786
|
use cfd simul investig shear stress hydrodynam cavit reactor coupl experiment valid use coloni count measur current work investig shear stress distribut hydrodynam cavit reactor two differ geometri use cfd simul venturi type posit geometri bore negat geometri use induc cavit experiment valid predict simul also conduct calcul reduct rate coloni count legionella pneumophila pathogen bacteri strain numer experiment studi reveal signific influenc shape cavit induc geometri flow characterist distribut shear stress simul data indic high shear stress format posit geometri venturi cavit rang two reactor far apart experiment studi also confirm flow condit venturi type reactor favour compar bore geometri result bacteri reduct effici high clear demonstr geometri cavit devic play crucial role decid shear stress efficaci desir applic per predict simul model valid experiment result
|
D057446
|
T070
|
36,302,784
|
gpr trigger inflammatori process human neutrophil via macromolecular complex upstream par activ neutrophil play essenti anti microbi inflammatori role host defens howev activ requir tight regul dysfunct often lead detriment inflammatori autoimmun diseas show adhes molecul gpr alloster activ cd associ membran proteinas mpr conjug sever protein interact partner lead neutrophil activ human crystallograph delet analysi gpr extracellular region identifi two independ mpr bind domain mechanist effici bind activ mpr gpr requir macromolecular cdgprparcdb complex induc activ par g protein coupl receptor known function inflamm trigger par upstream complex lead strong inflammatori activ prompt anti microbi activ endotheli dysfunct role complex patholog inflamm underscor find gpr mpr upregul surfac diseas associ neutrophil summari identifi par activ mechan direct neutrophil activ thus inflamm prcdgprparcdb protein complex therefor repres potenti therapeut target neutrophil mediat inflammatori diseas
|
D018375;D009504;D044464;D043562
|
T039;T116;T025;T192
|
36,302,782
|
gaug skin resid leishmania parasit loop mediat isotherm amplif lamp assay post kala azar dermal leishmaniasi despit avail high sensit polymeras chain reaction pcr base method dearth remot deploy diagnost tool circumv earli accur detect individu post kala azar dermal leishmaniasi pkdl evalu design lock loop mediat isotherm amplif lamp assay diagnos pkdl total snip skin sampl collect individu probabl pkdl clinic present posit rk rapid diagnost test rdt assess microscopi qpcr lamp equal number age sex match healthi control includ determin specif lamp assay lamp assay qiagen dna extract q lamp show promis sensit ci identifi pkdl case lamp assay sensit declin dna extract use boil spin method q qpcr show sensit compar lamp excel agreement wherea microscopi exhibit weak sensit microscopi andor qpcr consid gold standard q lamp exhibit elev sensit ci detect pkdl case bayesian latent class model substanti excel sensit assay healthi control found negat notwithstand optimum effici lamp assay toward detect pkdl case optim boil spin method warrant permit remot use assay
|
D007898;D007893;D010271;D016773;D012876
|
T047;T204
|
36,302,781
|
sea level extrem compound marin heatwav coastal indonesia low lie island nation like indonesia vulner sea level height extrem hex compound marin heatwav hex larger ecolog societ impact combin observ model simul investig hex compound height heat extrem chhex along indian ocean coast indonesia recent decad find anthropogen sea level rise combin decad climat variabl caus increas occurr hex hex chhex driven equatori wester longshor northwest wind anomali hex occur decemb march downwel favor northwest monsoon wind enhanc enhanc vertic mix limit surfac warm chhex wind anomali associ negat indian ocean dipol iod co occur la nia weaken southeast cool coastal upwel may june novemb decemb find emphas import interplay anthropogen warm climat variabl affect region extrem
|
D059000;D014919
|
T070
|
36,302,779
|
endotheli alpha globin nitrit reductas resist arteri vasodil respons hypoxia essenti match tissu oxygen demand hypoxia erythrocyt hemoglobin tetram produc nitric oxid nitrit reduct hypothes alpha subunit hemoglobin express endothelium also facilit nitrit reduct proxim smooth muscl creat two mous strain test endotheli specif alpha globin knockout ec hba anoth alpha globin allel mutat prevent alpha globin inhibitori interact endotheli nitric oxid synthas hbawt ec hba mice signific decreas exercis capac intracellular nitrit consumpt hypox condit effect absent hbawt mice hypoxia induc vasodil signific decreas arteri ec hba hbawt mice hypoxia also lower blood pressur ec hba mice conclud presenc alpha globin resist arteri endothelium act nitrit reductas provid local nitric oxid respons hypoxia
|
D009572;D009569
|
T121;T197;T126;T116
|
36,302,777
|
human cooper chang group larg scale public good game peopl cooper provid public good import scientif question relat mani societ problem previous research studi peopl cooper stabl group repeat one time encount howev real world public good problem occur group gradual chang composit due old member leav new member arriv group chang relat cooper public good provis well understood address issu analyz dataset onlin public good game compris approxim million contribut decis made thousand player thousand group thousand chang group composit find chang group composit negat relat cooper result suggest relat individu contribut less role newcom role incumb process move newcom status incumb status individu cooper line incumb
|
D005716;D003299
|
T170;T054
|
36,302,776
|
benchmark emerg depart predict model machin learn public electron health record demand emerg depart ed servic increas across globe particular current covid pandem clinic triag risk assess becom increas challeng due shortag medic resourc strain hospit infrastructur caus pandem result widespread use electron health record ehr access vast amount clinic data allow us develop predict model decis support system address challeng date wide accept clinic predict benchmark relat ed base larg scale public ehr open sourc benchmark data platform would streamlin research workflow elimin cumbersom data preprocess facilit comparison among differ studi methodolog base medic inform mart intens care iv emerg depart mimic iv ed databas creat benchmark dataset propos three clinic predict benchmark studi provid futur research insight suggest protocol manag data develop predict tool emerg care
|
D019985;D000086382
|
T081;T047;T067
|
36,302,775
|
ubiquitin proteolysi cdk relat kinas regul titan cell format virul fungal pathogen cryptococcus neoforman fungal pathogen often undergo morpholog switch includ cell size chang adapt host environ caus diseas pathogen yeast cryptococcus neoforman form call titan cell infect titan cell larg polyploid display alter cell wall capsul resist phagocytosi various type stress titan cell format regul camppka signal pathway stimul protein gpa show gpa activ phosphoryl cdk relat kinas crk target degrad e ubiquitin ligas fbp strain overexpress crk allel lack pest domain exhibit increas product titan cell similar fbp mutant convers crk delet result reduc titan cell product indic crk stimul titan cell format crk phosphoryl gpa local plasma membran activ camppka signal pathway induc cell enlarg furthermor titan cell overproduc strain trigger increas th th cytokin product cd cell show attenu virul mous model system cryptococcosi overal studi provid insight regul titan cell format fungal virul
|
D003455;D003453
|
T047;T004
|
36,302,774
|
hepat thyroid hormon signal modul glucos homeostasi regul glp product via bile acid mediat fxr antagon thyroid hormon th regul system glucos metabol incomplet understood mechan show improv glucos metabol hypothyroid mice treatment accompani increas glucagon like peptid glp product insulin secret co treatment glp receptor antagonist attenu effect insulin glucos level use mice lack hepat th receptor tr liver specif tr select agonist demonstr tr mediat hepat th signal requir regul glp product insulinotrop glucos lower effect moreov administr liver target tr select agonist increas glp insulin level allevi hyperglycemia diet induc obes mechanist suppress cypb express result increas level farnesoid x receptor fxr antagonist bile acid therebi potenti glp product insulin secret repress intestin fxr signal correl plasma glp fecal fxr antagonist bile acid level peopl normal thyroid function thus studi reveal role hepat th signal glucos homeostasi regul glp product via bile acid mediat fxr antagon
|
D001647;D052216
|
T123;T116;T109
|
36,302,773
|
distinct mammalian disom collis interfac harbor k link polyubiquitin us trigger hrqt mediat subunit dissoci translat stall event result ribosom collis induc ribosom associ qualiti control rqc order degrad potenti toxic truncat nascent protein rqc induct collid ribosom first mark helznf e ubiquitin ligas recruit rqt complex subunit dissoci yeast us polyubiquitin hel wherea es preferenti monoubiquitin znf human cell unknown reason character ubiquitin activ znf import human rqt mediat subunit dissoci use endogen xbpu poli translat staller cryo em analysi human collid disom reveal distinct composit interfac substanti differ yeast collid disom biochem analysi collid ribosom show znf form k link polyubiquitin chain us decis mammalian rqc initi human rqt hrqt complex compos ascc ascc trip dissoci collid ribosom depend atpas activ ascc ubiquitin bind capac ascc hrqt mediat subunit dissoci requir k link polyubiquitin us monoubiquitin es us suffici therefor conclud znf function mark collid mammalian ribosom k link polyubiquitin us trimer hrqt complex mediat subunit dissoci
|
D002352;D012441;D029701
|
T123;T004;T116
|
36,302,771
|
dynam hiv spike motion creat vulner membran bound tripod antibodi attack vaccin target hiv gp spike protein stymi high viral mutat rate structur chicaneri gp membran proxim extern region mper target natur aris broad neutral antibodi bnab yet mper base vaccin fail generat bnab nanodisc embed spike protein investig cryo electron microscopi molecular dynam simul reveal spontan ectodomain tilt creat vulner hiv mper protom radiat central toward three fold axi contribut membran associ tripod structur occlud upright spike tilt provid access oppos mper structur spike protein bound e bnab fab reveal antibodi bind expos mper therebi alter mper dynam modifi averag ectodomain tilt impos strain viral membran spike transmembran segment result abrog membran fusion inform futur vaccin develop
|
D015497;D016915
|
T129;T005;T121
|
36,302,770
|
molecular insight dna recognit methyl non canon type restrict modif system type restrict modif system help establish prokaryot dna methyl landscap provid protect invas dna addit classic modif non canon type enzym catalyz mc use altern dna modif subunit report crystal structur non canon paciimm methyltransferas bound target dna reaction product adenosylhomocystein close clamp like conform target dna bind tight within central tunnel mms complex form extens contact three protein subunit unexpect target cytosin proper insert pocket target adenin either unmethyl methyl anchor outsid pocket uniqu asymmetr catalysi establish paciimm precis coordin relat conform differ subunit evolv specif amino acid within mm work provid insight mechan mamc catalysi guidanc design tool base type restrict modif enzym
|
D015280;D004247
|
T123;T126;T116;T114
|
36,302,769
|
arctic introgress chromatin regul facilit rapid qinghai tibet plateau colon avian predat qinghai tibet plateau qtp possess climat cold arctic also present uniqu low oxygen concentr intens ultraviolet uv radiat qtp anim adapt extrem condit whether obtain genet variat arctic cold adapt genom mutat non code region regul gene express hypoxia intens uv environ remain larg unknown assembl high qualiti saker falcon genom resequ popul across eurasia identifi femal bias hybrid arctic gyrfalcon last glacial maximum endow eastern saker allel convey larger bodi size chang fat metabol predispos qtp cold adapt discov qtp hypoxia uv adapt main involv independ chang non code genom variant studi highlight key role gene flow arctic relat qtp hypothermia adapt cis regulatori element hypox respons uv protect
|
D002843;D006824
|
T045;T116
|
36,302,767
|
epitheli coxsackievirus adenovirus receptor promot hous dust mite induc lung inflamm airway inflamm remodel import pathophysiolog featur asthma respiratori condit intact epitheli cell layer crucial maintain lung homoeostasi depend intercellular adhes whilst damag respiratori epithelium primari instig airway inflamm coxsackievirus adenovirus receptor car high express epithelium modul cell cell adhes stabil facilit immun cell transepitheli migrat howev contribut car lung inflamm remain unclear investig mechanist contribut car mediat respons common aeroallergen hous dust mite hdm demonstr administr hdm mice lack car respiratori epithelium lead loss peri bronchial inflammatori cell infiltr fewer goblet cell decreas pro inflammatori cytokin releas vitro analysi human lung epitheli cell confirm loss car lead reduc hdm depend inflammatori cytokin releas neutrophil migrat epitheli car deplet also promot smooth muscl cell prolifer mediat gsk tgf basal matrix product airway hyperrespons data demonstr car coordin lung inflamm dual function leucocyt recruit tissu remodel may repres import target futur therapeut develop inflammatori lung diseas
|
D011014;D039981;D011991
|
T123;T050;T116;T192;T109;T204;T047
|
36,302,763
|
human mtrf termin cox translat ablat induc mitochondri ribosom associ qualiti control translat termin requir releas factor read stop codon decod center subsequ facilit hydrolysi nascent peptid chain peptidyl trna within ribosom human mitochondria eleven open read frame termin standard uaa uag stop codon recogn mtrfa propos major mitochondri releas factor howev two transcript encod cox nd termin non convent aga agg codon respect translat termin achiev two case known address long stand open question show non canon releas factor mtrf special releas factor trigger cox translat termin mtrfa termin major mitochondri translat event includ non canon nd loss mtrf lead isol cox defici activ mitochondri ribosom associ qualiti control accompani degrad cox mrna prevent overload ribosom rescu system taken togeth result establish role mtrf mitochondri translat mysteri decad lead comprehens pictur translat termin human mitochondria
|
D000069396;D010454;D024101;D051545
|
T026;T123;T126;T116
|
36,302,762
|
cryo em structur attrwt amyloid fibril system non hereditari transthyretin amyloidosi wild type transthyretin deriv amyloid attrwt major compon non hereditari transthyretin amyloidosi accumul heart elder patient life threaten varieti genet variant transthyretin lead hereditari transthyretin amyloidosi show differ clinic symptom like age onset pattern organ involv howev case non hereditari transthyretin amyloidosi attrwt fibril deposit locat primarili heart tissu structur studi analyz attrwt amyloid fibril heart patient non hereditari transthyretin amyloidosi present reconstruct densiti map attrwt fibril use cryo electron microscopi compar previous publish vm variant attr fibril extract heart eye differ patient structur show remark similar spearhead like shape cross section form n c termin fragment transthyretin minor differ demonstr common featur attr fibril despit differ mutat patient
|
D028227;D011228
|
T123;T047;T116
|
36,302,761
|
target vasoact intestin peptid mediat signal enhanc respons immun checkpoint therapi pancreat ductal adenocarcinoma pauciti effector cell within tumor render pancreat ductal adenocarcinoma pdac resist immun checkpoint therapi sever develop approach target immun suppress cell tumor microenviron less focus improv cell function show inhibit vasoact intestin peptid receptor vip r signal enhanc anti tumor immun murin pdac model silico data mine immunohistochemistri analysi primari tumor indic overexpress neuropeptid vasoact intestin peptid vip human pdac tumor elev vip level also present pdac patient plasma supernat cultur pdac cell furthermor cell regul vip receptor activ identifi vip signal pathway potenti target enhanc cell function mous pdac model vip r antagonist peptid synerg anti pd antibodi treatment improv cell recruit tumor activ tumor antigen specif cell inhibit cell exhaust contrast limit singl agent activ anti pd antibodi vip r antagonist peptid combin therapi elimin tumor anim furthermor tumor free mice resist tumor challeng indic anti cancer immunolog memori generat vip r signal thus repres tumor protect immun modulatori pathway target pdac
|
D021441;D010190
|
T191
|
36,302,758
|
ablat cd cell recognit immunodomin epitop sar cov omicron variant ba ba ba emerg sar cov omicron variant rais concern escap vaccin induc immun number studi demonstr reduct antibodi mediat neutral omicron variant vaccin individu preliminari observ suggest cell less like affect chang omicron howev complex human leukocyt antigen genet impact upon immunodomin cell epitop select suggest mainten cell immun may univers studi describ impact chang omicron ba ba ba recognit spike specif cell cell constitut immunodomin cd cell respons hla covid convalesc vaccin individu howev fail recogn omicron encod sequenc observ demonstr addit evas antibodi mediat immun chang omicron variant also lead evas recognit immunodomin cell respons
|
D016056;D000086382
|
T129;T047;T067
|
36,302,757
|
transient inhibit p enhanc prime edit cytosin base edit effici human pluripot stem cell precis gene edit human pluripot stem cell hpscs hold great promis studi potenti treat human diseas prime edit base edit avoid introduc doubl strand break low edit effici make techniqu still arduous process hpscs report co deliv pdd domin negat fragment p great enhanc prime edit cytosin base edit effici generat precis mutat hpscs appli pe combin pdd effici creat multipl isogen hpsc line includ line carri gba lrrk mutat associ parkinson diseas lmna mutat link hutchinson gilford progeria syndrom also correct gba lmna mutat patient specif ipsc data show pdd improv pe effici without compromis genom wide safeti make feasibl safe routin generat isogen hpsc line diseas model
|
D039904;D057026
|
T025
|
36,302,756
|
limit glutamin util activ gcntrail rcaspas apoptot pathway glutamin addict tumor cell oncogen transform lead chang glutamin metabol make transform cell high depend glutamin anabol growth surviv herein investig cell death mechan activ glutamin addict tumor cell respons limit glutamin metabol show glutamin starvat trigger fadd caspas depend mitochondria oper apoptot program tumor cell involv pro apoptot tnf relat apoptosi induc ligand receptor trail r independ cognat ligand trail glutamin deplet tumor cell activ amino acid sens general control nonderepress kinas gcn respons trail r upregul caspas activ apoptot cell death interest gcn depend isr signal induc methionin starvat also lead trail r upregul apoptosi moreov pharmacolog inhibit transaminas activ gcn trail r depend apoptot mechan inhibit non essenti amino acid neaa addit metabol stress upon glutamin depriv also result gcn independ flice inhibitori protein flip downregul facilit caspas activ apoptosi import downregul long flip splice form flip l apoptosi upon glutamin depriv inhibit presenc membran permeabl ketoglutar collect data support model limit glutamin util glutamin addict tumor cell trigger previous unknown cell death mechan regul gcn involv trail r mediat activ extrins apoptot pathway
|
D005973;D053220
|
T123;T121;T116;T192
|
36,302,755
|
liquid biopsi gastric cancer predict prognost biomark gastric cancer gc high incid cancer worldwid patient diagnos advanc stage time limit treatment option poor prognosi earli diagnosi precis treatment import past year emerg research conduct use non invas liquid biopsi advantag minim invas repeat sampl monitor tumor occurr recurr real time evalu prognosi treatment respons mani studi demonstr potenti liquid biopsi gc detect circul tumor cell ctcs circul tumor dna ctdna circul free dna cfdna exosom achiev gratifi result review summar evolv technolog inform regard liquid biopsi recent discov gc liquid biopsi biomark ongo clinic trial discuss challeng applic prospect liquid biopsi gc
|
D013274;D000074141;D009360
|
T191;T025;T114
|
36,302,754
|
oncogen fusion protein dnajb prkaca specif target peptid base immunotherapi fibrolamellar hepatocellular carcinoma dnajb prkaca fusion transcript oncogen driver fibrolamellar hepatocellular carcinoma lethal diseas lack specif therapi studi report identif character immunotherapeut applic hla present neoantigen specif dnajb prkaca fusion transcript fibrolamellar hepatocellular carcinoma dnajb prkaca deriv hla class hla class ii ligand induc multifunct cytotox cd helper cd cell cellular process present dnajb prkaca express tumor cell demonstr mass spectrometri base immunopeptidom analysi singl cell rna sequenc identifi multipl cell receptor dnajb prkaca specif cell vaccin fibrolamellar hepatocellular carcinoma patient suffer recurr short interv diseas relaps dnajb prkaca deriv peptid continu poli adp ribos polymeras inhibitor therapi induc multifunct cd cell activ helper phenotyp high cell receptor clonal vaccin induc dnajb prkaca specif cell respons persist time contrast various previous treatment accompani durabl relaps free surviv patient month post vaccin preclin clinic find identifi dnajb prkaca protein sourc immunogen neoepitop correspond cell receptor provid efficaci singl patient studi cell base immunotherapi specif target oncogen fusion
|
D006528;D008113
|
T191
|
36,302,751
|
senesc neutrophil deriv exosom pirna promot chemoresist emt breast cancer via fto mediat demethyl cellular senesc character tumor suppress program well pro inflammatori secretom neutrophil constitut signific composit malign play key role tumor develop howev role senesc neutrophil cancer progress present unexplor demonstr neutrophil display enhanc senesc breast cancer patient receiv chemotherapi senesc neutrophil produc increas number exosom confer drug resist tumor cell vitro vivo mechanist senesc neutrophil deriv exosom pirna enhanc express fat mass obes associ protein fto breast cancer cell upregul fto strengthen zeb transcript stabil express decreas n methyladenosin rna methyl lead chemoresist epitheli mesenchym transit emt tumor cell clinic level exosom pir correl poor chemotherapi respons patient breast cancer addit ythdf essenti posttranscript regul zeb pirna fto signal senesc neutrophil secret exosom pir stat depend manner altogeth studi suggest senesc neutrophil deriv exosom pir confer chemoresist tumor cell senesc neutrophil may serv potenti therapeut target breast cancer
|
D058750;D001943
|
T191;T043
|
36,302,750
|
ik ca channel control breast cancer metabol includ ampk driven autophagi ca activ k channel intermedi conduct ik frequent overexpress breast cancer bc cell ik channel deplet reduc bc cell prolifer tumorigenesi rais question whether mechanist ik activ interfer metabol activ energi consumpt rate fundament rapid grow cell use bc cell obtain mmtv pymt tumor bear mice show glycolysi mitochondri atp product reduc cell deriv ik defici breast tumor loss ik alter sub cellular k ca homeostasi mitochondri membran potenti ultim result reduc atp product metabol activ consequ find bc cell lack ik upregul amp activ protein kinas activ induc autophagi compens glycolyt mitochondri energi shortag result emphas ik modul cellular ca k dynam contribut remodel metabol pathway cancer thus target ik channel might disturb metabol activ bc cell reduc malign
|
D051660;D001943
|
T123;T191;T116
|
36,302,749
|
mutat lncrna increas risk type diabet promot cell dysfunct insulin resist islet cell dysfunct insulin resist main pathogenesi type diabet td mechan remain unclear identifi rs c mutat lncrna regcp main express islet associ increas risk td analys chines adult reveal mut regcp individu higher incid td present impair insulin secret well increas insulin resist mice islet cell specif mut regcp knock sever cell dysfunct insulin resist mass spectrometri assay protein rna pulldown demonstr mut regcp direct bind polypyrimidin tract bind protein ptbp immunofluoresc stain western blot analysi qpcr analysi glucos stimul insulin secret test reveal mut regcp disrupt stabil insulin mrna inhibit phosphoryl ptbp cell furthermor islet deriv exosom transfer mut regcp peripher tissu promot insulin resist inhibit adipor translat adiponectin signal find identifi novel mutat lncrna involv pathogenesi td reveal new mechan develop td
|
D003924;D007333;D050417;D007515;D062085
|
T123;T025;T023;T114;T047;T046
|
36,302,717
|
let talk negat experi black mental health servic user england moment consid watch wait support recoveri watch wait concept tradit associ sever endur mental ill paper howev bold argu concept could use ground break access antidot perceiv inequ experienc black servic user experienc mild sever mental ill england novel concept propos paper intend consensu rather uncompromis provok critic think mental health practic conceptu framework watch wait mental health suggest
|
D008605;D001523
|
T058;T048
|
36,302,707
|
antibiot develop multiresist gram negat bacilli rapid increas antibiot atb resist among gram negat bacilli bgn especi strain enterobacteriacea pseudomona aeruginosa acinetobact baumannii high resist pattern xdr pose huge threat health system worldwid last decad differ atb develop xdr combin lactam along lactamas inhibitor other use non lactam inhibitor adequ vitro activ sever lactamas class c ambler howev combin ceftazidimeavibactam ceftolozanetazobactam meropenemvaborbactam activ metallo lactamas ml new combin aztreonanavi cefepimezidebactam new cephalosporin cefiderocol efficaci ml enzym although combin alreadi approv commerci phase mani yet defin place within treatment microorgan high resist clinic studi
|
D000900;D006090
|
T121;T007;T195
|
36,302,680
|
chang treatment burden among peopl multimorbid follow survey treatment burden effort requir patient look health impact function wellb littl known chang treatment burden time peopl multimorbid
|
D000076322;D058006
|
T078;T091
|
36,302,651
|
palmit impair circadian transcriptom muscl cell histon modif enhanc obes elev circul lipid may impair metabol disrupt molecular circadian clock test hypothesi lipid overload may interact circadian clock alter rhythmic gene express epigenom mechan skelet muscl palmit reprogram circadian transcriptom myotub without alter rhythmic mrna express core clock gene gene enhanc cycl respons palmit associ post translat modif histon cycl histon lysin acetyl hkac marker activ gene enhanc modifi palmit treatment chromatin immunoprecipit sequenc confirm palmit exposur alter cycl dna region associ hkac overlap mrna dna region associ hkac pharmacolog inhibit histon acetyltransferas reveal novel cycl gene associ lipid exposur primari human myotub palmit exposur disrupt transcriptom rhythmic modifi enhanc chang histon hk acetyl circadian manner thus histon acetyl respons lipid overload may redirect circadian chromatin landscap lead reprogram circadian gene pathway involv lipid biosynthesi skelet muscl
|
D006657;D059467
|
T081;T123;T116;T086
|
36,302,650
|
circexoc promot acut lung injuri ptbpskprunx axi activ autophagi understand pathogenesi acut lung injuri ali focus circexoc signific regul circular rna ali use vivo cecal ligat punctur clp induc ali mous model vitro lps challeng mous pulmonari microvascular endotheli cell mpvec model examin impact knockdown circexoc lung injuri inflamm autophagi regul circexoc polypyrimidin tract bind protein ptbp phase kinas associ protein skp runt relat transcript factor runx investig combin rna immunoprecipit qrt pcr mrna stabil ubiquitin assay signific ptbp circexoc induc ali phenotyp examin vitro vivo circexoc regul associ increas inflamm activ autophagi cecal ligat punctur induc ali lung tissu lps challeng mpvec interact ptbp circexoc acceler skp mrna decay e ubiquitin ligas runx therefor increas runx express function overexpress ptbp revers shcircexoc inhibit ali inflamm autophagi signal cascad circexocptbpskprunx essenti regul inflamm autophagi mpvec aggrav sepsi induc ali
|
D055371;D050659;D034441;D038941;D044786;D000079962
|
T123;T116;T037;T114
|
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