PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,666,190 | identif risk predict model clinic prognosi posit breast cancer patient background new biomark need identifi differ clinic outcom breast cancer bc method differenti gene bc screen base tcga databas use wgcna identifi gene relat surviv genet algorithm use structur risk predict model prognost model valid gse data result construct risk predict model gene identifi prognosi bc includ cleca pld pim ptkb aknad corf kaplan meier curv show model effect distinguish surviv bc patient multivari cox regress suggest risk model independ predictor bc analysi relat immun show signific differ immun infiltr high low risk group classifi prognost model conclus studi identifi risk predict model gene could distinguish prognosi bc | D001943 | T191 |
34,666,189 | increas insulin signal anophel stephensi fat bodi regul metabol enhanc host respons bacteri challeng plasmodium falciparum infect vertebr invertebr insulininsulin like growth factor igf signal ii cascad high conserv play vital role mani differ physiolog process among mani tissu respond ii mosquito fat bodi central role metabol lifespan reproduct innat immun previous demonstr fat bodi specif express activ akt key ii signal molecul adult anophel stephensi aed aegypti activ ii cascad extend lifespan addit found transgen femal produc vitellogenin vg protein non transgen mosquito although translat increas fecund result prompt us examin ii impact immun metabol growth develop transgen mosquito observ signific chang glycogen trehalos triglycerid glucos protein young transgen mosquito relat non transgen sibl control triglycerid signific chang older transgen mosquito import demonstr enhanc fat bodi ii decreas preval intens plasmodium falciparum infect transgen stephensi addit challeng transgen stephensi gram posit gram negat bacteria alter express sever antimicrobi peptid amp two anti plasmodium gene nitric oxid synthas nos thioester complement like protein tep relat non transgen control increas ii fat bodi adult femal stephensi littl impact bodi size growth develop progeni transgen mosquito relat non transgen control studi confirm expand understand critic role insulin signal play regul divers function mosquito fat bodi | D054884;D015398 | T040;T044;T043 |
34,666,188 | evolutionari diversif insulin relat peptid irp aphid spatiotempor distribut acyrthosiphon pisum member insulin superfamili activ evolutionarili high conserv insulininsulin like growth factor signal pathway involv regul growth energi homeostasi longev current studi focus aphid gain insight evolut irp may contribut regul insulin signal pathway use latest annot pea aphid acyrthosiphon pisum genom combin sequenc align phylogenet analys identifi seven putat irp encod gene irp irp resembl classic insulin insulin like protein structur irp irp bear insulin like growth factor igf featur also identifi irp new structur diverg irp present least eight aphid genom global ten aphid genom analyz work contain four irp three irp found genom grape phylloxera hemipteran insect repres earlier evolutionari branch aphid group express analys reveal spatial tempor variat express pattern differ pisum irp irp irp express throughout development stage morph neuroendocrin cell brain irp irp express fat bodi irp express specif cell gut aphid non crowd condit head aphid crowd condit irp salivari gland irp irp male morph irp express enrich carcass complex spatiotempor express pattern suggest function diversif irp | D019143 | T038 |
34,666,187 | chemic proteom analysi palmostatin beta lacton analog affect n ras palmitoyl palmitoyl revers post translat lipid modif regul protein traffick signal enzymat depalmitoyl protein inhibit beta lacton palmostatin b found target sever serin hydrolas effort better understand mechan action palmostatin describ herein synthesi chemic proteom analysi function character analog compound identifi palmostatin analog maintain inhibitori activ n ras depalmitoyl assay display complementari reactiv across serin hydrolas class measur activ base protein profil activ palmostatin analog inhibit recent character abhd subfamili depalmitoyl enzym spare candid depalmitoylas lypla lypla find improv understand structur activ relationship palmostatin refin set serin hydrolas target relev compound effect n ras palmitoyl dynam | D040901 | T091 |
34,666,186 | impact pelvic nodal radiotherapi hematolog toxic systemat review focus leukopenia lymphopenia futur perspect prostat cancer treatment hematolog toxic ht particular leukopenia common side effect oncolog treatment pelvic malign pelvic nodal radiotherapi pnrt associ ht develop main incident bone marrow bm irradi howev sever question remain clinic impact radiotherapi relat ht herein perform systemat review avail evid pnrt ht | D007970;D008231;D011471;D050397 | T191;T047;T061 |
34,666,185 | insuffici sampl frequenc skew heart rate variabl estim implic extract heart rate metric neuroimag physiolog data cardiac pulsat wide present within physiolog neuroimag data unknown extent inform provid valid reliabl heart rate heart rate variabl hrv estim object studi demonstr slight tempor shift due insuffici sampl frequenc impact validityaccuraci deriv cardiac metric | D019985;D004562 | T074;T060;T081 |
34,666,184 | peptid conjug glycyrrhetin acid potent inhibitor glucosidas age induc oxid glycyrrhetin acid ga known sever biolog activ focus extens research develop therapeut agent current studi ga peptid conjug evalu vitro glucosidas inhibitori antiglyc activ structur activ relationship sar establish molecular interact activ bioconjug enzym bind site predict molecular model approach tripeptid moieti conjug peptid residu posit found signific role glucosidas inhibit activ ga peptid conjug ga cys tyr gli ga pro tyr gli exhibit sever fold potent glucosidas inhibit ic valu compar standard drug acarbos ic kinet studi potent compound reveal conjug exhibit competit type inhibit conjug show non competit type inhibit simul studi also support kinet result conjug ga cys tyr gli inhibit glucosidas enzym block substrat bind site age induc inhibitor play import role control inflamm associ diabet mellitus peptid conjug also evalu vitro age induc inhibit use raw macrophag cell line data reveal conjug potent age induc inhibitor compar standard rutin pdtc peptid conjug competit inhibitor glucosidas also exhibit strong inhibitori activ age induc product furthermor peptid conjug found non cytotox mous fibroblast nih murin macrophag raw cell line conclus data demonstr besid possess strong glucosidas inhibit newli synthes peptid conjug also allevi age induc product raw macrophag dual inhibit glucosidas enzym age induc product ga peptid conjug qualifi research anti diabet drug discoveri | D006034;D000520 | T116;T121;T126;T109 |
34,666,183 | revers tumor immunosuppress microenviron via target codeliveri cpg odnspd l peptid antagonist enhanc immun checkpoint blockad base anti tumor effect order revers tumor immunosuppress microenviron improv antitumor immun effect base immun checkpoint block mannos modifi liposom base cpg odn pd l antagonist peptid p co deliveri system ham lipo cpg p construct hyaluron acid ha coat suppos improv system circul stabil therebi promot accumul tumor tissu ham lipo cpg p complex enter tumor tissu ha hydrolyz action hyaluronidas expos p peptid p peptid link octapeptid cleav matrix metalloproteinas mmps releas tumor tissu action mmps exert block effect pd pd l pathway lipo cpg complex recogn macrophag surfac mannos receptor surfac modifi mannos molecul promot intracellular deliveri cpg odn therebi activ macrophag result show ham lipo cpg p complex success revers type macrophag tumor microenviron tme therebi activ anti tumor relat immun cell inhibit tumor growth moreov ham lipo cpg p complex show better tumor inhibitori effect ham lipo cpg ham lipo p monotherapi treatment group overal ham lipo cpg p complex provid promis co deliveri strategi target tumor improv antitumor effect base immun checkpoint blockad | D060890;D059016 | T070;T129;T116 |
34,666,182 | protocol random control trial sit reduct improv cardiometabol health older adult older adult obes spend major wake hour sedentari given substanti barrier regular physic activ popul approach reduc sedentari time could effect health promot strategi present protocol random control trial reduc sit time older adult bodi mass index kgm particip n random receiv sit reduct intervent term stand healthi live focus attent control condit stand includ contact health coach session total particip receiv wrist worn prompt devic portabl stand desk healthi live condit includ session health coach set goal around various topic relat healthi age particip receiv assign intervent month month receiv stand condit random receiv five booster health coach session phone contact healthi live particip receiv contact condit follow addit month measur initi includ wear activp devic complet sever biometr test eg blood pressur hbac baselin month month month howev covid pandem shift remot assess unabl collect measur primari outcom remain activp assess sit time blood pressur recruit anticip complet | D000086382;D002318 | T047;T067 |
34,666,180 | silver carboxyl dope titanium dioxid polydimethylsiloxan coat decreas cutibacterium acn adher biofilm format polyeth ether keton cutibacterium acn c acn gram posit facult anaerob found deep sebac follicl skin shoulder back c acn increas recogn pathogen spinal surgic site infect ssi especi presenc instrument | D012834;D014025 | T196 |
34,666,179 | comparison novel machin vision spinal imag guidanc system exist fluoroscopi base navig system random prospect studi use spinal imag guidanc system ig increas patient safeti accuraci oper effici reduc revis rate pedicl screw placement procedur tradit intraop fluoroscopi ct imag produc potenti harm ioniz radiat increas oper time regist patient ig flash navig use machin vision high resolut stereoscop camera structur visibl light build topograph map patient boni surfac anatomi enabl navig use without ioniz radiat | D065289;D013123;D025321 | T074;T061 |
34,666,172 | identif novel irf homozyg mutat caus neutrophilia monocytopenia fatal infect femal neonat inborn error immun iei result mutat gene involv host immun defens immun regul herein report identif novel irf mutat neonat iei dna sampl neonat parent subject dna sequenc immun status patient assess identifi mutat cc p arg interferon regulatori factor irf gene manifest sever dysfunct neutrophilia l monocytopenia l patient cd cell cd cell count decreas level ifn low even sever infect mrna express level irf lower normal clinic manifest includ recurr progress fatal infect sinc irf play key role differenti develop immun cell suspect novel mutat cc p arg may consist sever loss irf function result failur immun cell differenti matur lead sever infect earli onset | D009154 | T045 |
34,666,171 | carrageenan exacerb citrobact rodentium induc infecti coliti mice target gut microbiota intestin barrier integr near half centuri scientif communiti unabl agre upon safeti profil carrageenan cgn ubiquit food addit littl known mechan consumpt cgn aggrav etiopathogenesi murin coliti howev analys gut microbiota intestin barrier integr provid breakthrough explain synergist effect cgn upon coliti citrobact rodentium induc infecti murin coliti inflamm clinic sever gut tissu aggrav presenc cgn use fecal transplant germ free mice experi evalu role intestin microbiota pro inflammatori effect cgn mice high dietari cgn consumpt show alter colon microbiota composit result degrad colon mucus layer rais fecal lps level decreas presenc bacteri deriv short chain fatti acid scfas mucus layer defect alter fecal lps scfa level could reproduc germ free mice fecal transplant cgn h fed mice germ free cgn h fed mice result confirm cgn may creat environ favor inflamm alter gut microbiota composit gut bacteri metabol present studi provid evid gut microbiota barrier axi could altern target amelior coliti promot effect cgn | D044082;D003092;D004756 | T007;T047 |
34,666,170 | phylogenet relationship evolut host prefer largest clade brood parasit bee apida nomadina brood parasit also known cleptoparasit repres substanti fraction global bee divers rather construct nest speci instead invad host bee lay egg larva hatch consum food provis intend host offspr life histori strategi evolv numer time across phylogeni bee oldest specios parasit clade subfamili nomadina apida howev phylogenet relationship among brood parasit apid within outsid nomadina fulli resolv present new find phylogeni divers group brood parasit base ultraconserv element uce sequenc data extens taxon sampl nomadin speci repres tribe suggest broader definit subfamili nomadina describ clade includ almost parasit member famili apida tribe melectini form sister group nomadina remaind subfamili compos two sister clade nomadin line repres former nomadina sensu stricto ericrocidin line unit sever most neotrop lineag find tribe osirini handlirsch polyphylet divid three lineag includ newli describ parepeolini trib nov addit taxonom find use phylogeni explor evolut differ mode parasit detect two independ transit close cell open cell parasit final examin nomadin host parasit associ evolv time support emeri rule suggest close relationship host parasit confirm earliest nomadin parasit close free live relat within famili apida time host rang broaden includ distant relat host span divers bee expand breadth host taxa may also associ transit open cell parasit | D010271 | T204 |
34,666,169 | combin genom phenotyp sanger sequenc data elucid phylogeni two claw spider dionycha import morpholog phylogenom era recent gain attent relat studi combin type inform infer phylogenet relationship sanger sequenc legaci data also import understand evolutionari relationship possibl combin genom morpholog sanger data one analysi seem compel permit complet sampl yield comprehens view evolut group use three data type elucid systemat evolut dionycha high divers group spider relat underrepres phylogenet studi dataset analyz separ combin differ infer method includ novel approach analyz morpholog matric common use evolutionari model test altern hypothes relationship perform simul investig accuraci find provid comprehens thorough phylogenet hypothesi dionycha serv robust framework test hypothes evolut key charact also show morpholog data might phylogenet impact even massiv outweigh molecular data approach analyz morpholog data may serv altern propos practic arbitrarili partit weight choos parsimoni stochast model result find propos trachycosmida new rank group australian genera former includ trochanteriida gallieniellida consid ammoxenida junior synonym gnaphosida restor famili rank prodidomida transfer subfamili molycriina gnaphosida drassinella transfer liocranida donuea corinnida mahafalytenus viridasiida | D023281;D010641;D010802;D013112 | T091;T032;T204;T078;T062 |
34,666,168 | valu updat genbank access supermatrix phylogeni case new guinean marsupi carnivor genus myoicti erron taxonom attribut genbank access mislead phylogenet infer appear widespread within genera investig influenc taxonom misattribut reconstruct phylogeni three stripe dasyur includ four recogn myoicti speci marsupialia dasyurida distribut across new guinea nearbi island molecular phylogenet studi focus dasyurid consist resolv interrelationship small carnivor group leucura wavicus place wallacei mela success deeper diverg two recent marsupi mammalian supermatrix phylogeni instead favour altern myoicti topolog discord relationship add new nuclear mitochondri sequenc employ random access resampl show supermatrix topolog artefact sever outdat taxonom attribut genbank updat access bring agreement across myoicti phylogeni random resampl access encourag author updat genbank taxonom attribut argu option need flag access demonstr incorrect provid anomal result would serv caution futur supermatrix construct highlight access potenti signific biolog interest studi | D008394 | T015 |
34,666,166 | short cours corticosteroid treatment close loop insulin deliveri system experi dblg pre launch abstract brief report | D003922;D007328 | T116;T047;T121;T125 |
34,666,165 | serum uric acid earli pregnanc risk gestat diabet mellitus cohort studi pregnant women higher serum uric acid ua associ increas risk type diabet mellitus cohort studi examin whether associ serum ua earli pregnanc subsequ risk gestat diabet mellitus gdm | D003924;D016640 | T047 |
34,666,163 | optim udp xyl biocatalyt synthesi crassostrea giga orthogon design method udp xyl nucleotid sugar involv biosynthesi various glycoconjug difficult obtain quit expens biocatalysi use one pot multi enzym cascad one valuabl biotransform process wide use industri herein two enzym udp glucos udp glc dehydrogenas cgiugd udp xyl synthas cgiux pacif oyster crassostrea giga coupl togeth biotransform udp xyl character optimum ph determin ph cgiugd ph cgiux enzym show highest activ c neither enzym metal ion depend basi singl factor orthogon test appli optim condit biotransform udp xyl udp glc orthogon design l conduct optim process variabl enzym amount ph temperatur convers udp xyl select analysi indic optimum variabl ratio cgiugd cgiux enzymat ph temperatur c confirm three repeat valid experi udp xyl convers ml reaction mixtur optim condit h first report biosynthesi udp xyl oyster enzym | D055162 | T070 |
34,666,162 | identif prostat cancer use multiparametr mr imag characterist prostat tissu referenc whole mount histopatholog studi object character mr signatur various benign prostat tissu differenti cancer data seventi prostat cancer patient underw multiparametr mri mpmri subsequ prostatectomi scan includ weight imag tw diffus weight imag dynam contrast enhanc mri dce mri mr spectroscop imag histopatholog tissu inform translat mri imag mpmri paramet character separ per zone tissu type tissu order accord trend tissu paramet mean peripher zone tissu order cystic atrophi high grade prostat intraepitheli neoplasia hgpin normal atrophi inflamm cancer decreas valu tissu order exhibit adc mm mm tw intens increas valu occur dce mri peak dce mri slope min min fraction anisotropi fa cholin cholin citrat transit zone tissu order cystic atrophi mix benign prostat hyperplasia bph normal atrophi inflamm stroma anterior fibromuscular stroma cancer decreas valu occur adc mm mm tw intens increas valu occur dce mri peak dce mri slope min min fa cholin cholin citrat logist regress use creat paramet model fit differenti cancer benign prostat tissu fit achiev auc studi quantifi mpmri characterist benign prostat tissu demonstr capabl mpmri discrimin among benign well cancer tissu potenti aid futur discrimin cancer benign confound | D011467;D011471 | T191;T023 |
34,666,161 | tractem evalu protocol determinist tractographi white matter atlas reproduc identif white matter pathway across subject essenti studi structur connect human brain one key challeng anatom differ subject human rater subject label label white matter region interest present mani challeng due need integr local global inform clear communic manual process captur inform cumbersom yet essenti lay solid foundat comprehens atlas segment protocol must design interpret request task well locat structur landmark anatom accur intuit reproduc work quantifi reproduc first iter openpubl multi bundl segment protocol allow us establish baselin reproduc well identifi limit futur iter protocol testedevalu typic research acquisit baltimor longitudin studi age blsa high acquisit qualiti human connectom project hcp dataset result show rudimentari protocol produc accept intra rater inter rater reproduc howev work highlight difficulti general reproduc result import reach consensus anatom descript white matter pathway protocol made avail open sourc improv generaliz reliabl collabor goal improv upon first iter initi discuss anatom valid lack thereof bundl definit import reproduc tractographi segment | D063132;D066127 | T091;T017;T023;T024 |
34,666,160 | compress sampl magnet reson imag reconstruct base split bregman iter general non uniform threshold shrinkag k space sampl reconstruct technolog effect mean improv speed magnet reson imag among mani reconstruct algorithm split bregman iter effect method solv multi constrain model model often contain tv variat regular term general threshold shrinkag oper often use solv tv constraint subproblem howev general threshold shrinkag oper perform shrink oper consid inconsist element imag matrix caus loss imag detail | D007091;D008279 | T170;T066;T059;T060 |
34,666,159 | averag sar predict valid evalu compact mr scanner head size rf coil recent develop compact ct mri scanner high perform gradient dedic radiofrequ rf transmit coil expos head neck small portion upper bodi region head first scan due uniqu coil geometri patient posit establish sar model use convent whole bodi scanner direct translat ct specif absorpt rate sar estim valid framework develop use implement dedic accur sar predict model ct two differ sar predict model ct defin evalu one base anatom deriv expos mass one use fix anatom posit locat caudal rf coil determin expos mass coil model virtual human bodi simul design sar predict model implement ct verifi calorimetri vivo scan power monitor fix demarc expos mass model select appropri expos mass region accur estim sar deposit patient ct | D008279;D011846 | T070;T170;T059;T060 |
34,666,158 | radiom nomogram analysi fblade tse pulmonari nodul evalu develop valid radiom nomogram differenti malign pulmonari nodul benign nodul | D008175;D049451 | T191;T170;T081 |
34,666,150 | cytotox cellular uptak metabol short chain metabolit tocomonoenol similar rrr tocopherol hepg cell contrari major vitamin e congen tocopherol carri satur sidechain tocotrienol threefold unsatur sidechain littl known intracellular fate tocomonoenol minor vitamin e deriv singl doubl bond c posit sidechain hypothes due structur similar uptak metabol tocomonoenol resembl tocopherol cytotox cellular uptak tocomonoenol tocopherol tocotrienol convers short chain metabolit cehc cmbhc studi hepg cell tocomonoenol show signific effect cell viabil uptak similar observ tocopherol signific lower tocotrienol tocomonoenol main metabol cmbhc liver cell lower extent tocotrienol tocopherol metabol quantifi amount summari similar cytotox uptak metabol tocomonoenol tocopherol suggest minor vitamin e congen deserv attent futur research regard potenti vitamin e activ | D014810;D024502 | T127;T121;T109 |
34,666,149 | fda approv l type channel blocker nifedipin reduc cell death hypox cell modul mitochondri calcium superoxid generat hypoxia major driver pathophysiolog covid crucial character hypox respons cellular molecular level order augment drug repurpos identif appropri molecular target investig therapeut prevent hypox cell damag requir work propos hypoxia model base alveolar lung epitheli cell line use chemic induc cocl use test calcium channel blocker ccbs sinc recent studi suggest ccbs may reduc infect sar cov specif select fda approv calcium channel blocker nifedipin studi first examin hypoxia induc cell morpholog found signific increas cytosol calcium level mitochondri calcium overload well ros product hypox cell second demonstr protect behaviour nifedipin cell alreadi subject hypoxia measur cell viabil well imag cellular morpholog nuclear condens third show protect effect nifedipin achiev reduct cytosol calcium mitochondri calcium ros generat overal outlin framework quantit analysi mitochondri calcium ros use imag laser scan confoc microscopi open sourc imag analysi platform imagej propos pipelin use visual mitochondri calcium ros level individu cell provid understand molecular target find suggest therapeut valu nifedipin may potenti evalu context covid therapeut trial | D000086382;D009543 | T047;T121;T109;T067 |
34,666,147 | bacteri cellulos potenti biomed applic bacteri cellulos bc import polysaccharid synthes bacteri speci specif cultur condit present sever remark featur microporos high water hold capac good mechan properti good biocompat make potenti biomateri medic applic sinc discoveri bc use wound dress drug deliveri artifici blood vessel bone tissu engin forth addit bc simpli manipul form deriv composit enhanc physicochem function properti sever polym carbon base nanomateri metal nanoparticl nps introduc bc ex situ situ method design hybrid materi enhanc function properti review provid comprehens knowledg highlight recent advanc bc product strategi structur featur various situ ex situ modif techniqu potenti biomed applic | D001672;D002482 | T122;T109;T123 |
34,666,146 | character evalu ascorb acid induc cell sheet format human periodont ligament stem cell vitro studi periodont ligament deriv stem cell pdlscs regard viabl option periodont regener use cell sheet technolog object present vitro studi character human pdlscs base phenotyp biolog properti evalu ascorb acid aa vitamin c induc cell sheet analyz molecular marker | D010513;D013234 | T025;T023;T030;T081 |
34,666,145 | mid term outcom chimney endovascular aortic aneurysm repair systemat review meta analysi provid overview literatur mid term outcom chimney evar chevar treatment juxtaren abdomin aortic aneurysm jaaa | D019917;D057510 | T061 |
34,666,144 | origin methodolog studi polymer nanoparticl macrophag interact nanoparticl track analysi cell cultur media quantif intern object poli lactic acid pla poli lactic co glycol acid plga among employ co polym prepar drug nanocarri treatment cancer infecti diseas consid clinic use necessari understand interact polymer nanoparticl nps physiolog environ especi immun cell propos simpl yet precis method assess nps intern kinet macrophag base direct analysi cell cultur media differ incub time proof concept given use fluoresc plga nps nanoparticl track analysi nta method choic enabl detect individu np analyz trajectori brownian motion compar dynam light scatter dls nta enabl precis determin np size distribut uptak process rapid one hour around third nps intern addit intern nps visual confoc microscopi fluoresc cellular stack analyz use freeli avail macro imagej softwar particleincel intern object local count methodolog could serv studi analyz effect nps size shape surfac properti interact various cell line | D053758;D011100 | T122;T073;T109 |
34,666,143 | needl free mental incis nerv block vitro cadaver pilot clinic studi present studi aim optim needl free liquid jet inject nflji mental incis nerv block minb evalu clinic safeti feasibl minb protocol develop optim seri nflji experi soft tissu phantom cadav valid two pilot random control trial rct nflji penetr depth found direct proport suppli pressur volum high pressur nfljis kpa creat maximum forc total work signific greater needl inject low pressur nfljis kpa howev produc result similar needl inject addit high pressur nfljis creat jet imping pressur maximum jet penetr pressur higher low pressur nfljis pilot rcts reveal high pressur nflji caus high risk discomfort paresthesia meanwhil low pressur nflji less like caus complic preliminari success rate minb cadav use nfljis needl comparison rcts respect conclud nflji suppli pressur adjust achiev effect minb minim complic furthermor cadav studi pilot rcts confirm feasibl non inferior rct | D009339;D009407 | T074;T061 |
34,666,142 | effect crosslink physicochem properti polydimethylsiloxan base levonorgestrel intrauterin system polydimethylsiloxan pdms base levonorgestrel intrauterin system lng iuss mirena long act drug devic combin product design releas lng contracept purpos year lng iuss consist hollow cylindr drug pdms reservoir mount polyethylen frame cover outer pdms membran pdms releas control excipi present matrix outer membran degre pdms crosslink key paramet lng ius manufactur dictat elast mechan strength critic paramet mold demold cylindr reservoir addit elast mechan strength also import prevent deform insert uterin caviti object studi investig impact pdms crosslink physicochem properti lng iuss develop appropri test method character mechan strength formul differ degre crosslink prepar vari ratio pdms elastom base crosslink agent novel solvent swell extract method develop determin degre pdms crosslink extent crosslink also character via ftir raman h nmr dsc tga dynam mechan analysi expect formul higher degre crosslink show lower crystallin interest less crystallin formul show higher tg valu storag moduli compar high crystallin formul impli crosslink predomin paramet govern physicochem mechan properti lng iuss correl establish pdms crosslink physicochem properti lng iuss use qualiti control purpos formul screen develop better understand physicochem characterist complex product facilit drug product develop | D003271;D007436 | T074;T121 |
34,666,139 | qualiti life initi treatment atrial fibril cryoablat versus drug therapi stop af first trial recent demonstr initi treatment cryoballoon ablat cba safe superior antiarrhythm drug aad therapi prevent atrial arrhythmia recurr patient symptomat atrial fibril af | D003452;D011788 | T061;T078 |
34,666,138 | group mother base feed practic associ dietari qualiti pre school children latent profil analysi parent feed practic associ children food intak howev littl known pattern feed practic use group mother group practic influenc children dietari intak therefor aim studi classifi describ group mother accord pattern feed practic examin associ group matern feed practic pre school children dietari qualiti mother base australia children age year complet onlin survey includ valid measur nine feed practic dietari qualiti measur use thirteen sum dietari item latent profil analysi use identifi distinct group mother share similar feed practic linear regress model fit examin associ feed practic profil child dietari qualiti three profil model chosen base interpret profil size statist model fit criteria profil lower mean score structur relat feed practic profil profil mean score reflect slight higher use structur relat feed practic lower mean score non respons feed practic profil higher mean score non respons feed practic profil profil ci profil ci lower mean child dietari qualiti score compar profil profil reflect engag structur relat feed practic combin least non respons feed practic associ higher child diet qualiti compar two profil identif uniqu profil could help tailor futur intervent consid pattern feed practic use group mother | D005247;D009035 | T040;T092;T099;T055 |
34,666,137 | stress fed effect stress matern feed behavior moder role execut function stress associ rang unhealthi eat habit yet studi examin stress may influenc intergener transmiss eat habit parent children specif lack data regard role stress feed practic moreov work investig associ parent stress feed behavior correl limit understand causal current studi use experiment design induc high low stress mother use standard laboratori stressor observ mother child interact snack break also examin potenti role matern execut function ef buffer effect stress matern feed behavior level matern stress manipul trier social stress task tsst communiti sampl n dyad child age month femal measur matern ef seri computer task matern feed behavior code control behavior includ pressur restrict behavior result indic main effect stress control feed behavior mother high stress condit exhibit higher level control behavior effect stress control feed behavior amelior among mother higher level ef control child age incom result provid causal evid role stress feed behavior suggest ef factor consid treatment prevent diet relat ill | D056344;D008425 | T054;T041 |
34,666,136 | age relat chang trb igh repertoir healthi adult male femal divers immun repertoir capabl recogn enorm univers foreign antigen encount life age profound impact immun repertoir howev whether continu age relat chang immun repertoir differ sex unclear studi characterist immun repertoir stratifi sex age deciph analyz cell receptor chain trb immunoglobulin heavi chain igh sequenc healthi adult similar chang observ male femal across lifespan wherea age subgroup analysi reveal sex specif signatur trb igh repertoir regard trb male repertoir rich even increas slight age year year respect decreas sharpli thereaft intrigu femal decreas signific around age year old subsequ undergo stabl stage age year although igh repertoir even increas signific age sex rich decreas signific age male remain stabl femal moreov averag length igh cdr increas age conclus find provid fundament insight mechan under sex differ adapt immun | D000375;D007143;D016693 | T116;T129;T192;T040;T033 |
34,666,135 | neosaxitoxin paralyt shellfish poison phycotoxin block pain inflamm equin osteoarthr osteoarthr chronic diseas character progress deterior articular cartilag produc strong inflammatori activ chronic pain patient hors also show osteoarthr sinc activ progress diseas similar human develop studi model hors studi test effect neosaxitoxin phycotoxin paralyt shellfish poison remedi osteoarthr equin clinic symptom pain show lame inflamm quantifi amount pro inflammatori marker like cellular infiltr tnf alpha nitric oxid synovi fluid obtain hors damag joint outcom show neosaxitoxin block pain long last period averag day furthermor amount pro inflammatori marker reduc consequ enhanc hors well obtain neosaxitoxin show candid establish treatment protocol oa safe effect pain blocker equin osteoarthr | D006734;D010003;D011042 | T131;T047 |
34,666,134 | structur conform physicochem rheolog properti flaxse gum extract alkalin acid condit present work aim investig extract protocol base consecut step isoelectr point ph mediat gum swell deproteinis altern method produc flaxse gum extract enhanc techno function characterist osid proxim composit structur conform flow behaviour dynam rheolog thermal properti gum isol brown golden flaxse assess gum extract near isoelectr point condit impair extract yield residu protein ash content whilst result minor chang sugar composit flaxse gum extract deconvolut gpcsec chromatograph reveal presenc four major polysaccharid popul correspond arabinoxylan rhamnogalacturonan two ax rg composit fraction latter appear minimis intra interchain polym non coval interact hydrogen bond lead better solvat affin water lyotrop solvent golden flaxse gum exert higher molecular weight w da intrins viscos dl g well better thicken viscoelast perform brown flaxse gum exemplar golden flaxse gum exhibit better thermal stabil compar brown flaxse counterpart therefor suitabl product applic involv sever heat treatment | D006863;D008968;D012212 | T082;T059;T057;T081 |
34,666,132 | print properti cellulos nanofibril reinforc quinc seed mucilag bio ink plant base hydrogel attract great attent biomed field sinc biocompat base natur sustain cost effect wide access sourc introduc new viscoelast bio ink compos quinc seed mucilag cellulos nanofibril qsmcnf easili extrud lattic structur direct ink write ambient condit qsmcnf ink enabl precis control print fidel cnf endow object shape stabil freez dri suitabl poros water uptak capac mechan strength compress elast moduli sampl produc highest cnf content increas kpa kpa kpa respect valu ideal match report soft tissu accord cell compat print sampl evalu hepg cell human liver cancer result confirm hydrogel non cytotox suitabl support attach surviv prolifer cell newli develop ink allow sustain bio hydrogel fit requir scaffold soft tissu engin | D066330 | T073 |
34,666,130 | mechan barrier properti starch blend film enhanc kaolin applic food packag starch blend film nativ cassava starch medium distarch phosphat cassava starch crosslink cassava starch prepar solut cast effect kaolin content water resist mechan properti starch blend film investig addit wt kaolin starch blend film lower water vapor permeabl g day pa water solubl rais tensil strength mpa load kaolin structur integr starch blend film maintain immers water thermal stabil enhanc scan electron microscopi reveal kaolin well dispers embed within starch matrix summari starch blend film composit wt kaolin interest properti materi replac non biodegrad synthet plastic packag particular sachet food product | D055598;D018857;D008567 | T070;T074;T073 |
34,666,129 | bacteri contamin smartphon healthcar worker german tertiari care hospit covid pandem assum hygien measur improv signific due covid aim investig bacteri colon smartphon sps own healthcar worker hcws pandem | D000086382;D000068997 | T047;T073;T067 |
34,666,124 | chang hospit lead ecg diagnost classif follow resuscit cardiac arrest evalu incid chang serial lead electrocardiogram ecg diagnost classif patient resuscit hospit oh cardiac arrest ohca compar oh emerg depart ed ecg | D004632;D058687 | T058;T046;T093;T061 |
34,666,123 | em agenc high rate field termin resuscit longer scene time also high rate surviv hospit cardiac arrest oohca manag dichotom strategi scoop run higher level care treat x goal return spontan circul rosc transport field termin resuscit ftor unsuccess resuscit hypothes em agenc greater averag time scene higher rate field termin resuscit would favor outcom | D016887;D004632;D058687 | T058;T046;T093;T061 |
34,666,122 | r frank jone urolog interest group intent strateg pipelin program increas divers urolog address low number urologist ethnic racial underrepres medicin urim nonprofit organ urolog unbound develop r frank jone urolog interest group rfjuig pipelin program provid mentorship research opportun profession develop urim student student complet questionnair part registr process rfjuig questionnair collect demograph inform ask experi pursu urolog goal particip program end student black latinx regist member rfjuig major member identifi immigr first generat american origin least differ countri member report earli interest field friend famili connect urolog urolog match applic member success match urolog resid posit intent strateg pipelin program increas recruit urim urolog thus far rfjuig success provid applic member tool need success match urolog | D013337;D014572 | T097;T091 |
34,666,118 | develop valid compet evalu model hospit infect prevent control practition post pandem era mix method studi coronavirus diseas pandem manag nosocomi infect becam even crucial urgent need develop compet model healthcar practition combat public health emerg | D000086382;D003428 | T047;T067 |
34,666,117 | factor predict non ventil hospit acquir pneumonia systemat review meta analysi hospit acquir pneumonia hap result approxim infect hospit two third patient use mechan ventil incid non ventil hospit acquir pneumonia nvhap increas associ longer length stay need intens care unit hospit mechan ventil use higher mortal | D003428;D000077299;D011014 | T047;T050 |
34,666,116 | advers event associ patient isol systemat literatur review meta analysi patient isol wide recommend use healthcar institut prevent transmiss multidrug resist organ mdros howev risk benefit ratio debat | D010356 | T061 |
34,666,115 | gut microbiota gut tissu metabolit involv develop prevent depress depress preval life threaten high recurr psychiatr ill sever studi shown depress associ endogen metabolit gut microbiota howev unclear whether metabolit differ gut tissu play role pathogenesi depress whether gut microbiota impact depress investig metabol signatur jejunum ileum colorectum use metabolom explor influenc gut microbiota develop chronic variabl stress cvs induc depress rat model variat gut tissu metabolit use gnotobiot rat model result show cvs induc disturb gut metabolit differenti metabolit differ effect differ segment cvs rat treat antibiot depress like etholog disord disappear decreas catecholamin level almost normal depress recoveri attribut influenc antibiot gut microbiota especi inhibit clostridiacea f candidatus arthromitus g lactobacillus g elev pseudomonadacea f moreov vari metabolit cvs rat revers antibiot treatment among increas metabolit decreas suggest trigger depress howev four decreas metabolit increas indic potenti therapeut effect depress base pearson correl analysi hypoxanthin hydroxypristan acid threonic acid l carnitin strong associ f f g g involv develop prevent depress find provid possibl explor pathogenesi prevent depress | D000069196 | T007;T001 |
34,666,114 | matern depriv induc cytoskelet alter depress like behavior adult male rat regul aktgskcrmp signal pathway earli life advers event exert persist effect brain function may increas risk psychopatholog adulthood howev under mechan remain unclear purpos studi studi long last effect matern depriv md depress relat behavior microtubul dynam illumin under molecular mechan rat pup separ dam min md min brief matern separ day postnat day rat md experi show signific depress like behavior adulthood brief matern separ alter behavior behavior alter md group accompani alter aktgskcrmp signal pathway hyperphosphoryl crmp crmp interact coloc cytoskeleton hippocampus overlap crmp tubulin stain hippocampus md rat decreas md rat express tubulin isoform acet tubulin tyr tubulin chang ratio tyracet tubulin import marker microtubul dynam decreas indic decreas microtubul dynam furthermor regul aktgskcrmp signal pathway ly microinject hippocampus result cytoskelet alter depress like behavior rat find suggest earli life md induc depress like behavior cytoskelet alter adult male rat effect may part mediat aktgskcrmp signal pathway understand mechan under effect md behavior crucial develop pharmacolog psycholog intervent childhood neglect | D008426;D051057 | T116;T126;T067 |
34,666,113 | cadmium mediat pancreat islet transcriptom chang mice cultur mous islet type ii diabet mellitus tdm multifactori diseas process character insulin resist impair insulin produc pancreat islet evid environment exposur cadmium contribut develop tdm presenc cadmium human islet general popul uptak cadmium cell report identifi cadmium mediat chang gene express molecular regulatori network pancreat islet perform next generat rna sequenc rna seq islet follow either vivo mm cdcl drink water ex vivo cdcl exposur exposur regiment result islet cadmium concentr compar found human islet general popul week vivo cadmium exposur upregul express five gene synj gjb rbpjl tri drik rbpjl known regul ctrb gene associ diabet suscept week vivo cadmium exposur found comprehens chang gene express profil pathway enrich analysi show secondari chang cluster molecular mechan relat intracellular protein traffick plasma membran islet cultur cadmium ex vivo signific induc express mt sphk nrcam lmbtl rnf itpr mt itpr known involv glucos homeostasi collect find report reveal complex cadmium mediat effect pancreat islet gene express environment relev cadmium exposur condit provid basi studi pathophysiolog process aris cadmium accumul pancreat islet | D020869 | T059;T063 |
34,666,112 | issu hazard risk assess perfluoroalkyl substanc mixtur scientif opinion risk human health relat presenc peruoroalkyl substanc food efsa tackl challeng task evalu risk pose potenti presenc per polyuoroalkyl substanc pfas assess cover peruoroalkyl carboxyl pfcas sulfon pfsas variabl chain length c c group larg number structur divers compound mani limit exposur absent toxic databas complex task commentari summar issu pitfal assess | D004781 | T037 |
34,666,111 | neural respons reflect symmetri shape defin binocular dispar shape perceiv region background human percept symmetri associ activ extend network extrastri visual area activ generat erp call sustain posterior negat spn studi far stimuli defin lumin test whether spn present stimuli defin stereoscop dispar use random dot stereogram rds experi compar spn signal contour specifi binocular dispar contour specifi monocular cue spn equival suggest type contour alter spn signal experi exploit uniqu properti rds provid unambigu figur ground arrang psychophys work shown symmetri easili detect properti singl object ie within figur compar properti gap two object ie ground therefor target region experi could either foreground background spn onset delay symmetri ground region may object format interfer process shape inform ground region | D005556;D015357 | T041;T081 |
34,666,107 | task switch reveal abnorm brain heart electrophysiolog signatur cognit healthi individu abnorm csf amyloidtau pilot studi electroencephalograph eeg alpha oscil relat heart rate variabl hrv chang alzheim diseas ad explor task switch reveal alter alpha power hrv cognit healthi individu ad patholog cerebrospin fluid csf whether hrv improv ad patholog classif alpha power alon compar low high alpha event relat desynchron erd hrv paramet task switch test two group cognit healthi particip classifi csf amyloidtau ratio normal ch nat n patholog ch pat n task switch paradigm particip requir name color word color word stimulus two sequenti stimuli per trial trial includ color cc word ww repeat low load repeat word cw color switch wc high load switch hrv assess rr interv standard deviat rr interv sdnn root mean squar success differ rmssd time domain low frequenc lf high frequenc hf lfhf ratio frequenc domain result show ch pat compar ch nat present increas less negat low alpha erd low load repeat trial lower word switch cost low alpha p cohen confid interv high alpha p cohen confid interv decreas hrv rest task suggest hyper activ sympatho vagal respons ch pat classif alpha erd improv supplement hrv signatur support potenti compromis brain heart interocept regul ch pat experi need valid find clinic signific | D000544;D001921 | T048;T047;T023 |
34,666,106 | heart wire cold explor cardiac marker callous unemot trait incarcer offend elev callous unemot cu trait repeat identifi subgroup offend display sever antisoci behavior establish physiolog marker may help improv earli identif treatment effort studi examin extent baselin rest heart rate hr heart rate variabl hrv use marker cu incarcer juvenil adult offend cu trait assess use inventori callous unemot trait result multipl hierarch regress test indic small yet signific posit associ baselin hr cu negat associ hrv cu juvenil offend medium model effect size r hr cu r hrv cu cardiac marker unrel cu adult offend find import demonstr impair cardiac autonom activ relat cu trait juvenil suggest socioemot process difficulti consid understand deficit futur research conduct larg sampl reactiv static condit includ cardiac covari get clariti interplay biolog system behavior express | D019955;D057237;D007604;D011329 | T048;T098;T055 |
34,666,105 | acut exercis cognit interact catecholamin hypothesi interocept model interocept model acut exercis cognit interact present exercis follow norepinephrin threshold interocept feedback induc increas tonic releas extracellular catecholamin facilit phasic releas henc better cognit perform execut function exercis intens increas maximum natur task induc norepinephrin releas locus coeruleus depend interact motiv perceiv effort cost perceiv avail resourc control interact rostral dorsolater prefront cortic orbitofront cortex anterior cingul cortex anterior insula cortex perceiv avail resourc suffici meet predict effort cost reward valu high tonic releas locus coeruleus attenu thus facilit phasic releas therefor cognit inhibit howev perceiv avail resourc insuffici meet predict effort cost reward valu low tonic releas locus coeruleus induc attenu phasic releas result cognit inhibit although long term memori task requir switch new stimuli respons coupl probabl facilit | D002395;D065812 | T121;T041;T123 |
34,666,104 | evalu angiogen properti brugia malayi asparaginyl trna synthetas mutant studi molecular target antifilari drug develop brugia malayi asparaginyl trna synthetas bmasnr identifi immunodomin antigen physiocrin mimic interleukin il induc chemotaxi angiogenesi endotheli cell comput analys shown n termin region bmasnr novel fold lysin rich hairpin helix flirtkkdgkqiw similar present il chemokin cxcr novel fold involv trna bind integr manifest diseas lymphat filariasi lf drug discoveri programm carri far lf success target bmasnr resist due diseas associ mutat mutat aar target shown correl sever diseas howev diseas associ mutat studi carri lf bmasnr establish target lf propos therefor studi effect singl point mutat bmasnr elucid molecular target understand molecular consequ mutat provid insight resist develop addit identif like resist confer mutat three mutant therefor generat site direct mutagenesi use cupsat server angiogen properti evalu cytometr analysi mutant endotheli cell cycl also carri cupsat predict protein stabil upon point mutat reveal two mutant generat like resist confer mutat three mutant show signific reduct angiogen properti reduct dna content cell gm phase thus show alter function gene encod drug target resist confer mutant howev show angiogen properti nearer wild type protein bmasnr futur work design newer drug may take consider drug resist confer mutat | D017178;D004605 | T204;T047 |
34,666,103 | comput screen potenti inhibitor target murf brugia malayi wolbachia multi scale molecular dock molecular dynam mm gbsa analysi lymphat filariasi parasit diseas caus worm wuchereria bancrofti brugia malayi brugia timori three anti filari drug name diethylcarbamazin ivermectin albendazol combin use control strategi filariasi diseas receiv much attent drug discoveri due unavail vaccin toxic pharmaceut properti exist drug wolbachia endosymbiont brugia malayi udp n acetylmuramoyl tripeptid alanyl alanin ligas murf play key role peptidoglycan biosynthesi pathway therefor consid effect drug target filariasi diseas therefor present studi murf select therapeut target identifi specif inhibitor filariasi homolog model perform predict three dimension structur murf due absenc experiment structur molecular dynam simul structur base high throughput virtual screen three differ chemic databas zinc maybridg spec carri identifi potent inhibitor also check conform insid bind site murf respect top three compound high dock score high relat bind affin murf select valid studi includ predict adm absorpt distribut metabol excret assess bind free energi use mm gbsa molecular mechan general born surfac area dft densiti function theori calcul perform top three compound result observ three compound predict show high reactiv accept rang pharmacokinet properti high bind affin drug target murf overal result could provid understand inhibit murf enzym screen compound could lead develop new specif anti filari drug | D017178;D004605;D020577 | T204;T047;T007 |
34,666,102 | role differ compon immun system plasmodium falciparum malaria possibl contribut toward malaria vaccin develop plasmodium falciparum malaria still remain major global public health challeng million new case well death annual death occur sub saharan africa bear malaria case high p falciparum malaria relat morbid mortal rate pose huge burden health econom wellb countri affect late substanti gain made reduc malaria morbid mortal intens malaria control initi use effect antimalari intens distribut use insecticid treat net itn implement massiv indoor residu spray ir campaign howev gain threaten widespread resist parasit antimalari vector insecticid year use vaccin proven reliabl cost effect effici method control burden spread mani infecti diseas especi resourc poor set limit public health infrastructur nonetheless case malaria promis malaria vaccin candid rts sas approv pilot implement programm three african countri regard import breakthrough fight malaria howev rts sas found limit main one low efficaci certain age group poor immunogen need almost three booster attain reason efficaci thus search robust effect malaria vaccin still continu better understand natur acquir immun respons various stage includ transmiss stage parasit could crucial ration vaccin design review therefor compil current known basic biolog p falciparum natur malaria immun respons malaria progress made toward vaccin develop | D000962;D008288;D017780;D016778 | T129;T047;T121 |
34,666,101 | imag intracellular protein interactionsact neuron use photon fluoresc lifetim imag microscopi decad photon fluoresc microscopi allow visual microstructur synaps high spatial resolut deep brain tissu howev signal transduct protein activ protein protein interact neuron tissu vivo remain elus technic difficulti observ biochem reaction level subcellular resolut light scatter tissu recent photon fluoresc microscopi combin fluoresc lifetim imag microscopi pflim enabl visual various protein activ protein protein interact submicromet resolut tissu reason tempor resolut thus far pflim extens appli imag kinas small gtpase activ dendrit spine hippocamp neuron slice cultur howev recent appli various subcellular structur axon termin nuclei increas understand spatial organ molecular dynam one futur direct pflim util combin various optogenet tool manipul protein activ combin allow activ specif protein light visual readout activ downstream molecul introduc recent applic pflim neuron present util new optogenet tool combin pflim | D036641;D009474 | T025;T059 |
34,666,099 | industri park generat intra heat island effect citi new evid quantit method contribut factor spatiotempor analysi top steel plant china industri park emit larg amount anthropogen heat aggrav urban heat island effect becom sever environment problem worldwid studi explor warm effect generat concentr industri facil ie steel plant studi produc intra heat island effect urban built area suffici evid industri heat island ihi effect lack new quantit method urgent need address issu therefor propos new scheme quantifi warm effect larg heat emit urban object versus complex surround ihi effect accord defin finer scale studi separ industri park artifici land comprehens estim ihi effect spatiotempor variat ihi intens measur base vari natur urban refer provid new evid exist ihi effect space season land surfac temperatur lst profil delin downward trend lst variat insid surround ihi case spatial tempor scale time seri analysi reveal ihi effect demonstr signific dispar regard lsts industri park surround background warm season cold season sever ihi effect observ spring summer weakest ihi intens occur winter moreov ihi intens posit associ anthropogen heat indic industri activ contribut increas lsts industri park great extent rational ihi effect broaden insight understand urban industri heat sourc influenc region thermal environ especi finer scale | D006358;D013232 | T070;T122 |
34,666,098 | drive factor air pollut reduct implement intens control polici ulsan south korea evalu control polici effect mitig criteria air pollut cap south korea decemb march difficult coincid covid social distanc studi differenti influenc three major drive factor intens control polici govern meteorolog condit social distanc cap variat ulsan largest industri citi south korea concentr pm pm decreas year respect wherea concentr slight increas year trend analysi use predict cap concentr januari februari februari march social distanc differ measur predict concentr design contribut three factor control polici import driver cap reduct particular contribut januari februari februari march pm decreas chang meteorolog condit consider affect cap reduct highest contribut januari februari februari march decreas februari march effect social distanc reduct pm pm respect overal decreas cap concentr appar januari march ulsan primarili due intens control polici covid social distanc | D000393;D000397;D000086382 | T047;T131;T067;T080;T069 |
34,666,097 | rethink term glyphos effect evalu differ glyphos base herbicid effect aquat microbi communiti glyphos base herbicid gbh wide use herbicid agricultur worldwid frequent general name glyphos howev gbh encompass varieti glyphos salt activ ingredi differ adjuv differ product herbicid reach water bodi produc divers impact aquat communiti yet risk assess assay requir approv focus most activ ingredi herein compar effect five differ gbh well monoisopropylamin salt glyphos gipa aquat microbi communiti natur shallow lake mix allow evolv outdoor pond perform day long assay indoor control condit evalu effect exposur structur nano plus microphytoplankton net phytoplankton size respect picoplankton size rang communiti microscopi flow cytometri respect signific differ effect evid structur microbi communiti depend gbh even herbicid share similar activ ingredi gbh evok increas differ magnitud bacterioplankton abund furthermor gipa formul decreas abund phycocyanin rich pc rich picocyanobacteria pci cytometr popul gipa alter pci composit also two gbh increas net phytoplankton total abund unlik test gbh appar effect gipa detect communiti structur result demonstr gbh effect aquat microbi communiti summar glyphos effect consid formul effect beyond exert activ ingredi alon work intend alert lack real knowledg regard consequ varieti gbh natur aquat ecosystem inde wide use term glyphos effect thorough rethought | D006540;D064307 | T131;T001;T032;T028 |
34,666,096 | consist inter annual reduct rice cadmium year biannual organ amend organ fertil may contain cadmium cd transform organ materi soil also role soil plant cd distribut lead cd accumul plant edibl part howev advis appli organ fertil remedi soil moder slight contamin cd clarifi studi investig impact organ amend chicken manur cd concentr rice grain cd r soil chemic properti five year period rice season within slight contamin paddi soil hunan provinc subtrop china found cd r reduc result organ amend within year reduct cd r higher late rice averag earli rice averag howev inter annual reduct cd r fair stabl suggest chicken manur amend long term persist remedi potenti concentr dtpa extract cd exchang plus water solubl cd fraction soil reduc wherea soil ph concentr soil organ c labil fraction increas result indic lower appar phytoavail cd soil follow organ amend two variabl empir model use dtpa cd extract soil full head stage rice climat factor total precipit rice grow season show great potenti effect predict cd r studi suggest cd phytoavail soil index dtpa extract exchang cd climat factor temperatur precipit may control inter annual reduct cd r follow organ amend slight contamin paddi soil | D002104;D012275 | T131;T002;T168;T196 |
34,666,095 | sustain biodiesel product microalga graesiella emersonii valor garden wast base vermicompost biodiesel product microalga gain signific interest recent due grow energi demand non renew natur petroleum howev high cost product environment health relat issu like excess use inorgan fertil eutroph major constraint commerci scale biodiesel product besid solid wast garden base manag also global concern present studi overcom limit vermicompost extract test nutrient sourc enhanc growth perform lipid product freshwat microalga graesiella emersonii mn garden wast first convert vermicompost manur extract aerob anaerob digest prepar efficaci extract test combin bg medium mixotroph cultiv microalga anaerob digest vermicompost extract combin bg medium enhanc cell biomass g wt l lipid product mg l day microalga two time moreov combin also improv satur methyl palmit monounsatur fatti acid oleic acid content test alga qualiti biodiesel also compli properti biodiesel standard provid india usa europ except cold filter plug properti combin also found improv cell biomass g l compar bg medium mass scale cultiv henc studi prove g emersonii grown media supplement garden wast base vermicompost extract signific potenti mass scale biodiesel bioproduct product | D000460;D058086 | T204;T002 |
34,666,094 | estim methan product anaerob digest greenhous horticultur wast real case studi almeria region methan product greenhous horticultur wast ghw almeria spain fruit veget export part europ calcul work combin experiment theoret method end eight sampl ghw collect character wast treatment plant collect sampl fair distribut throughout year ensur repres character amount methan produc hypothet anaerob digest process predict empir model fed experiment data experiment character reveal ghw contain adequ content volatil matter ts high valu total dri matter lignin content well low moistur content cn ratio inhibit compound also observ character cl methan product predict nm ch kg volatil matter may seem low comparison wast potenti usabl anaerob digest nonetheless co digest ghw wast could interest altern enhanc methan product solv season issu suitabl pre treatment also explor increas usabl ghw anaerob digest work establish theoret basi potenti solut manag ghw produc almeria | D008697;D014675 | T168;T109 |
34,666,093 | cover crop biomass incorpor enough compens negat impact plastic film mulch global warm plastic film mulch fm becam general practic enhanc crop product net primari product npp increas greenhous gas ghg emiss proper addit organ amend might effect decreas impact fm global warm evalu feasibl biomass addit decreas negat influenc cover crop biomass green manur incorpor differ recycl level aboveground biomass fm mulch net global warm potenti gwp integr soil c stock chang ghg n ch flux co equival evalu maiz cultiv biomass incorpor fm signific enhanc grain product npp maiz mulch respect contrast fm also high increas respir c loss higher npp increas mulch irrespect biomass recycl ratio mulch system negat necb indic decreas soil c stock observ main due big harvest remov fm decreas soil c stock mulch c stock clear increas increas biomass addit fm signific increas total n ch flux mulch respect soil c stock chang main decid net gwp scale n ch flux neglig influenc result fm high increas net gwp mulch net gwp clear decreas increas biomass applic howev cover crop biomass recycl enough compens negat impact fm global warm therefor biomass incorpor might essenti compens negat effect fm | D057232;D010969 | T167;T069 |
34,666,092 | assess face mask litter urban environ polici implic case bangkok face mask usag one prevent measur encourag worldwid limit transmiss sar cov pandem henc product mass use face mask rise due pandem well govern rule mandat citizen wear face mask howev improp dispos face mask pollut environ enorm hazard wast studi face mask litter assess urban environ bangkok carri three street citi select observ face mask litter h per day day moreov questionnair particip record determin mask handl dispos practic studi found total singl use face mask within km path furthermor highest lowest cumul litter record sunday monday respect buffer analysi show mask litter found within five mass transit station within singl street market respond use singl use face mask surpris dispos use face mask regular bin along household wast result highlight three polici implic tackl grow problem rais awar regul provis bin design use face mask strateg place support innov research eco friend face mask | D000086382;D008397 | T074;T047;T067 |
34,666,091 | use green roof greywat treatment role substrat depth plant recircul work focus use green roof modifi shallow vertic flow construct wetland greywat treatment build differ design paramet substrat perlit vermiculit substrat depth cm cm plant speci geranium zonal polygala myrtifolia atriplex halimus test determin optimum select addit applic recircul rate appli last month experi quantifi effici pollut remov experi conduct period month typic mediterranean climat condit lesvo island greec result show green roof plant atriplex halimus fill cm vermiculit best cod bod tss turbid averag remov effici contrast signific lower remov observ substrat depth decreas cm green roof veget signific impact tn remov averag tn concentr decreas mgl effluent unplant system mgl effluent green roof plant atriplex halimus recircul portion effluent influent result signific improv turbid organ matter especi nitrogen remov exampl bod remov green roof plant atriplex halimus fill cm perlit increas tn remov green roof plant plant fill cm vermiculit increas overal oper green roof modifi vertic unsatur construct wetland seem sustain natur base solut greywat treatment reus urban area | D004785 | T131 |
34,666,090 | microplast dump site soil six asian countri sourc plastic addit ubiquit distribut microplast mp serious environment issu asian countri studi open dump site soil collect cambodia india indonesia lao philippin vietnam analyz mp soil sampl also divid light float heavi sediment fraction densiti separ analyz plastic addit highest abund mp found soil cambodia pieceskg median mp soil rang pieceskg india pieceskg philippin suggest dump site major sourc mp environ polyethylen polypropylen polyethylen terephthal domin polym soil sampl analyz indic daili use plastic product main sourc mp dump site soil asian countri high concentr burden phthalat antioxid detect float fraction account total addit soil previous studi soil pollut assum organ hydrophob chemic analyz adsorb surfac soil particl howev result indic approxim half addit dump site soil deriv mp soil particl monitor studi soil pollut consid occurr mp matric | D000080545;D012989 | T131;T122 |
34,666,089 | review moss nitrogen isotop signatur evid atmospher nitrogen deposit moss nitrogen n concentr isotop composit n valu reveal better understand atmospher n deposit pattern summar moss n content n signatur use data compil paper base dataset summar model assess level reduc nh x oxidis compound x ratio atmospher n deposit result show histor increas n concentr n deplet specimen moss close anthropogen n sourc intens anim product agricultur activ nh x emiss sinc howev increas moss n less negat n observ last three decad could due substanti fossil fuel combust contribut x emiss spatial n deposit europ decreas due success control action asia becom hotspot nh x emiss agricultur present result highlight import moss n n valu estim atmospher n deposit pattern spatio tempor trend | D000393;D044002 | T131;T002 |
34,666,088 | erythromycin stimul rather inhibit methan product anaerob digest antibiot ferment dreg erythromycin ferment dreg efd one kind organ rich biosolid great potenti methan product howev influenc residu erythromycin eri anaerob digest process efd remain unclear studi batch test conduct differ eri concentr investig effect methanogenesi antibiot resist gene microbi communiti composit analyz explor potenti mechan result show eri remov day digest furthermor mgl eri present signific effect perform anaerob digest instead high concentr eri mgl increas rather inhibit methan yield moreov prolifer methylas gene eg ermat promot high pressur eri relat abund acetogen bacteria sedimentibact mixotroph archaea methanosarcina enhanc indic syntroph associ would play domin role stimul effect methanogenesi | D000900;D004917 | T195;T121;T109 |
34,666,087 | organophosph ester great lake fish improv analysi assess concentr human exposur via consumpt organophosph ester ope flame retard plastic chemic ad electron furnitur textil build materi consum product studi fillet fish often caught angler north american great lake lake trout salvelinus namaycush across four great lake nearshor fish speci near larg urban industri center toronto hamilton canada analyz ope rapid microextract homogen tissu methanol dramat reduc prepar sampl handl time achiev recoveri optim liquid chromatograph separ improv isomer separ includ aryl ope twelv ope detect frequenc detect rang five compound detect fish averag standard deviat sum ope ope rang l eri l superior ngg wet weight lake trout ngg wet weight nearshor fish speci toronto hamilton area aryl ope domin lake trout compris total ope concentr nearshor fish ope pattern reflect relat degre exposur run wastewat input sampl receiv environ intak ope via human consumpt great lake lake trout nearshor fish estim rang ngkg bodi weightday approxim order magnitud lower exposur via indoor air ingestioninhal dust order magnitud lower estim refer dose inclus addit ope analyt enabl pattern exposur accumul distinguish fish differ speci locat relat sourc food web influenc | D004952;D010755 | T109 |
34,666,086 | feed prefer insect larva wast electr electron equip plastic wast electr electron equip weee plastic pollut environ challeng treat environment friend manner biodegrad insect larva potenti eco friend method treat weee plastic inform feed prefer insect larva weee plastic lack studi total nine weee pristin plastic chosen feed larva follow two insect speci ie galleria mellonella tenebrio molitor g mellonella larva signific favor correspond pristin plastic compar two type weee plastic wast rigid polyurethan rpu wast polystyren ps one possibl explan increas chlorin metal weee plastic measur use x ray fluoresc spectromet analysi scan electron microscopi fourier transform infrar spectroscopi show destruct physic structur chang surfac function group found two type weee plastic larval frass impli larva part biodegrad plastic meanwhil powder wast high impact polystyren plastic whip ingest lumpi one indic consumpt g mellonella larva improv whip physic modif addit g mellonella larva present follow decreas prefer pristin plastic individu plastic fed mode rpu phenol formaldehyd resin polyethylen pe polypropylen ps polyvinyl chlorid possibl due differ physic properti chemic structur plastic feed prefer larva multipl plastic fed mode relat consist individu plastic fed mode interest consumpt g mellonella larva pe higher ps molitor larva show opposit trend impli insect larva differ plastic prefer find provid insight biodegrad weee plastic insect larva | D004581;D010969 | T167;T090 |
34,666,085 | snow rainfal independ affect densiti composit product ephemer temper desert snow rainfal two main water resourc requir veget growth gurbantunggut desert china epehmer import compon plant communiti temper desert earli spring tend sensit water avail type plant previous studi main focus separ effect snowpack rainfal growth paramet ephemer unclear whether interact snowpack rainfal situ field experi conduct snowpack rainfal manipul southern part desert two consecut year measur ephemer densiti composit biomass three snowpack three rainfal treatment result indic snow rainfal independ affect variat densiti composit product ephemer temper desert increas depth snow increas ephemer densiti dri year affect speci rich product dri wet year howev rainfal signific affect paramet dri year dramat effect wet year snowpack rainfal differenti affect seedl establish product effect independ matter dri wet year | D012914 | T070 |
34,666,084 | unravel radiocarbon composit organ carbon river sediment document past anthropogen impact river system carrier dissolv particul load connect continent surfac ocean river system play major role global carbon cycl inde riverin particul organ carbon poc melang various origin character c label addit civil nuclear activ brought new c sourc remain poor document propos unravel c valu poc store sedimentari archiv collect downstream nuclear european river loir river postul riverin poc mixtur aquat poc could impact liquid discharg nuclear industri terrestri petrogen poc combin radiocarbon measur poc analys palynofaci method assess respect c valu poc origin gap c valu sedimentari poc atmospher result dilut dead c freshwat reservoir effect imprint c aquat poc age transit time terrestri poc within catchment import consid unravel radiocarbon composit riverin poc could use determin either transit time materi sourc sink past industri natur event resili river system mileston social econom trajectori catchment last three decad riverin sediment could also act sourc radiocarbon atmospher | D002244 | T121;T196 |
34,666,083 | karst rocki desertif diverg soil resid activ ectomycorrhiz fungal communiti therebi foster distinct extramatr mycelia ectomycorrhiz fungi emf mutualist play crucial role liber nutrient acquisit transfer growth limit resourc provis water host plant terrestri ecosystem particular stress prone climat studi field base experi perform yunnan china assess effect karst rocki desertif krd natur forest non krd site rich composit emf communiti inert sand fill mesh bag employ character activ emf quantifi product extramatr mycelium emm result indic emf exhibit signific differenti among krd non krd site rich divers higher across krd area wherea even show opposit trend ascomycota zygomycota greater across krd site howev basidiomycota show differ across studi site relat abund clavaria butyriboletus odontia phyloporus helvella russula tomentella higher across krd site wherea clavulinopsi endogon amanita inocyb clavulina higher across non krd site worth note saprophyt sap fungal communiti found abund soil mesh bag site particular krd site like provid free space less competit emf thrive well mesh bag similar pattern ergosterol concentr mesh bag observ relat higher krd site non krd site entoloma amanita sebacina found substanti higher mesh bag soil across site delicatula helvella tomentella hand show higher relat abund mesh bag soil krd site howev differ across non krd site taken togeth present result highlight relationship emf communiti complex krd environ import restor disturb karst landscap | D000072761;D038821 | T004 |
34,666,082 | potenti hazard associ interact diesel exhaust particul matter pulmonari surfact long term exposur diesel exhaust particul matter depm induc numer advers health effect respiratori system understand interact depm pulmonari surfact ps essenti step toward preliminari evalu impact depm pulmonari health herein depm explor interact dipalmitoyl sn glycerol phosphocholin dppc major compon ps result indic surfac pressur area isotherm dppc monolay shift toward lower molecular area compress modulus c reduc presenc depm atom forc microscopi imag show depm disrupt ultrastructur dppc monolay along direct later compress addit dppc turn condit surfac properti depm permit agglomer aqueous media attribut adsorpt depm dppc furthermor particl bound polycycl aromat hydrocarbon pah could desorb depm solubil dppc posit correl hydrophob pah find reveal toxic depm associ pah role dppc facilit remov inhal particl provid new insight potenti hazard airborn particl lung health | D011663 | T121;T109;T123 |
34,666,081 | biogeochem mineralog effect fe p dynam sediment continent shelf sea impact salin oxygen condit catchment area characterist studi investig salin oxygen concentr catchment area characterist impact dynam fe p cycl continent shelf sea sediment sampl collect three site repres differ environment condit gdask deep southern baltic sea gotland deep central baltic sea bothnian sea northern baltic sea sediment analys miner composit speciat iron phosphorus main group prokaryota involv fe p cycl sediment indic concentr sulphat hydrogen sulphid alkalin chlorid calcium phosphat iron measur pore water demonstr eutroph southern region moder salin oxygen deficit bottom water sediment high potenti retain fe releas p indic high concentr pyrit labil form phosphorus respect strong salin stratif intermitt pelag redoxclin central baltic sea result clear higher rate pyrit deposit sediment enrich mn due format ca mn carbon driven intens mn redox cycl sulphat reduct high avail mn oxid connect episod inflow oxic seawat north sea sulphat present entir profil studi sediment gotland deep sediment well oxygen virtual fresh rich land deriv iron northern baltic sea retain signific amount p authigen miner organ matter mineralis surfac sediment area domin iron reduct variabl environment condit consequ avail electron acceptor caus region differ composit prokaryota communiti number sulphat reduc gdask gotland deep greater bothnian sea fe reduc bacteria oxidis fe | D054712 | T034 |
34,666,080 | nationwid studi air pollut particul matter daili hospit respiratori diseas itali relationship air pollut respiratori morbid wide address urban metropolitan area littl known effect non urban set aim assess short term effect pm pm respiratori admiss whole countri itali | D000397;D052638 | T167;T080;T069;T131 |
34,666,079 | impact data assimil meteorolog wrf model birch pollen model analys impact ground base data assimil weather research forecast wrf meteorolog model paramet relev birch pollen emiss calcul use two differ emiss databas base data assimil obsnud data assimil meteorolog model chemic transport model evalu birch pollen concentr final appli scale factor emiss base obsnud base ratio simul observ season pollen integr spin analys impact birch concentr central europ assimil observ data signific reduc model overestim air temperatur main paramet respons start pollen emiss amount releas pollen result also show relat small bias air temperatur model lead signific differ heat degre day hdd valu may caus hdd threshold attain sever day earlierlat indic observ data impact start pollen emiss even though bias air temperatur reduc obsnud model indic start birch pollen season earli compar observ start date season improv two station poland data assimil signific impact season end spin valu applic spin factor emiss result much closer birch pollen concentr level observ even though factor improv start end pollen season post process model meteorolog field applic bias correct consid way improv pollen emiss model | D029662;D055904 | T002;T090 |
34,666,078 | investig discrep mismatch repair immunohistochemistri microsatellit instabl polymeras chain reaction test result gynecolog cancer use next generat sequenc gynecolog cancer routin screen dna mismatch repair mmr gene mutat use immunohistochemistri ihc andor polymeras chain reaction pcr microsatellit instabl msi enabl select immun checkpoint inhibitor therapi screen lynch syndrom limit data compar ihc msi endometri tumor shown discord rate review mmrmsi result gynecolog cancer use next generat sequenc ngs interrog discrep case ihc msi result microsatellit stabl mss preserv mmr pmmr case msi high msi h mmr defici dmmr case show subclon loss mlh pms msi h case discord overal ihcmsi concord discord case retest andor subject ngs six discrep case five show dmmr mss one show pmmr msi h one dmmrmsi l case show loss pms germlin pathogen mutat pmmrmsi h case found harbor pathogen variant mlh msh one two case subclon popul demonstr msi h dmmr area mss pmmr area result emphas import select appropri tumor tissu ihc molecular test demonstr ngs help resolv discrep mmr msi result | D014408;D053843;D059014;D007150;D053842;D016133 | T049;T045;T123;T060;T059;T063 |
34,666,074 | pimavanserin hydroxytryptamin receptor invers agonist revers prepuls inhibit deficit nucleus accumben ventral hippocampus prepuls inhibit ppi disrupt mani neuropsychiatr diseas although invers agonist hydroxytryptamin ht receptor pimavanserin allevi ppi deficit rodent precis mechan critic brain area revers effect ht receptor invers agonist remain unclear present studi aim investig critic brain area respons revers effect ht receptor invers agonist ppi deficit male mice result show intraperiton administr pimavanserin found improv normal ppi behavior revers ppi deficit elicit dopamin receptor nonselect agonist pergolid local infus pimavanserin nucleus accumben ventral hippocampus revers ppi deficit wherea manipul medial prefront cortex ventral tegment area revers ppi deficit overal nucleus accumben ventral hippocampus critic brain area respons revers effect ht invers agonist ppi deficit find contribut extens explor accur molecular neural mechan under antipsychot effect ht receptor invers agonist especi neural circuit modul ht receptor activ | D058830 | T121 |
34,666,073 | novel nbco mof advanc peroxymonosulf catalyst organ pollut remov growth perform mechan studi multivari metal organ framework mtv mof expect catalyst appli advanc oxid process aop base sulfat radic treat wastewat contain organ pollut mix metal de novo method combin stringent solvotherm condit synthes macaroon like nbco mof catalyst nbco mof catalyst prepar differ atom ratio growth time present various morpholog structur perform distinct mtv mof growth law confirm sem tem ed xrd ftir raman spectra uv vis spectra besid optimum peroxymonosulf pms catalyt activ condit studi furthermor effect anion cl hco c nbco mof catalyt activ explor prove limit particular co co cycl combin nb nb cycl pms activ verifi xps epr quench experi result indic exist non radic pathway radic pathway domin oh moreov tc remov rate exhibit signific reduc three time run furthermor nbco mof exhibit excel decompos abil toward methylen blue tylosin tartrat rhodamin b tetracyclin remov rate reach min respect also maintain good perform actual water environ | D004785 | T131 |
34,666,072 | novel effici captur cr vi soil driven capillar evapor coupl soil contamin hexaval chromium cr vi pose sever environment threat owe carcinogen genotox characterist cr vi current field applic remedi technolog cr vi remov detoxif fail achiev optimum result owe various limit high energi consumpt high chemic cost secondari pollut long treatment durat herein novel strategi name capillari evapor membran cem method base ubiquit phenomena capillar evapor natur soil environ without extern forc appli remov cr vi contamin soil cem method enabl cr vi dissolv soil solut move upward soil pore inter particl space get attach surfac adsorpt membran coupl action capillar evapor achiev cr vi remov cem method show high cr vi remov capac day treatment bulk soil sandi fraction silt clay fraction respect research optim cem process condit could remark improv cr vi remedi perform exampl cr vi remov rate increas bulk soil prolong remedi period day studi demonstr new environ friend remedi method driven natur phenomena cr vi contamin soil | D002857;D012987 | T167;T131;T196 |
34,666,070 | carbonac composit membran peroxydisulf activ remov sulfamethoxazol real water matrix studi fabric carbonac composit membran load integr mat nitrogen dope graphen reduc graphen oxid carbon nanotub ngrgocnt nylon microfiltr substrat employ situ catalyt oxid activ peroxydisulf pds remov sulfamethoxazol smx real water matrix impact coexist organ perform carbonac catalysi investig continu filtrat mode reusabl test radic quench experi reveal non radic pathway surfac activ persulf main contribut smx degrad stabl smx remov flux r smx mg h obtain h tap water filter continu low pressur bar short contact time slight lower r smx mg h perform deioniz water control group addit higher content protein fulvic acid humic acid like organ result membran foul signific suppress smx remov long term filtrat chang product sulfat ion raman spectra carbon mat indic organ prevent structur defect carbon matrix particip pds activ moreov ngrgocnt composit membran coupl activ persulf oxid exhibit good self clean abil membran foul could part revers restor filtrat pressur oper studi provid novel effect oxid strategi effici smx remov water purif allow applic carbonac catalysi select degrad emerg contamin | D037742;D013420 | T121;T073;T109;T104;T195 |
34,666,068 | determin effect wind aid midg movement outbreak coexist multipl bluetongu virus serotyp patchi environ bluetongu virus btv serotyp coexist differ environ make control difficult wind aid midg movement known mechan spread btv howev effect dynam multipl btv serotyp clear ordinari differenti equat ode continu time markov chain ctmc model two btv serotyp environ divid two patch depend risk infect formul analys approxim ctmc model multityp branch process estim probabl major outbreak two btv serotyp obtain shown without movement major outbreak occur high risk patch cattl midg movement occur patch major outbreak occur numer simul ode model illustr possibl coexist patch patch connect midg cattl movement sensit analysi base latin hypercub sampl method identifi midg mortal bite rate import determin magnitud probabl major outbreak result indic signific wind aid midg movement outbreak coexist multipl btv serotyp patchi environ | D001819;D001820;D002519 | T204;T047;T005 |
34,666,066 | topolog featur limbic dysfunct chronic tinnitus intact hear new hypothesi nois cancel mechan reorgan limbic region extend general cognit network believ exist chronic tinnitus particular hub contribut nois cancel mechan test hypothesi investig topolog brain network tinnitus differ period | D009434 | T023 |
34,666,065 | prognost effect delay administr antimicrobi therapi older person experienc bacteremia without initi sepsi present investig prognost effect delay administr appropri antimicrobi therapi aat older person experienc bacteremia without initi sepsi syndrom respect | D016470;D018805 | T047;T046 |
34,666,063 | outcom minnesota detoxif scale mind assess high dose front load diazepam treatment alcohol withdraw hospit patient benzodiazepin gold standard alcohol withdraw treatment choic dose vari wide institut implement minnesota detoxif scale mind singl standard high dose diazepam base protocol treatment alcohol withdraw replac multipl clinic institut withdraw assess alcohol ciwa base protocol use lower dose benzodiazepin compar use mind versus ciwa assess protocol high front load diazepam treatment care patient experienc alcohol withdraw hospit | D000437;D013375 | T048;T184 |
34,666,060 | human pulmonari dirofilariasi review clinician human pulmonari dirofilariasi hpd rare zoonot diseas caus dirofilaria immiti nematod respons canin cardiopulmonari dirofilariasi dog heartworm incid hpd rise throughout world due increas awar factor affect vector mosquito human accident host immiti patient asymptomat present incident pulmonari nodul mimic primari metastat pulmonari malign patient suffer pulmonari system symptom acut phase pneumon caus pulmonari arteri occlus preadult worm result pulmonari infarct intens inflamm patient may ill defin pulmonari infiltr chest radiolog pulmonari nodul repres end result initi pneumon specif clinic laboratori radiolog find differenti hpd caus pulmonari nodul although serolog test exist usual commerci avail major patient diagnos histopatholog identif decompos worm follow surgic resect lesion | D004183;D004184;D006331;D008174;D055613 | T033;T204;T047 |
34,666,057 | screen biomark involv idiopath pulmonari fibrosi regul upstream mirna idiopath pulmonari fibrosi ipf common type fatal interstiti lung diseas ipf patient usual poor prognosi biomark predict occurr process prognosi ipf use diagnosi treatment studi aim identifi potenti biomark ipf analyz regul upstream mirna | D054990;D035683 | T047;T114;T123 |
34,666,046 | fatti acid induc format proteinac particl monoclon antibodi formul presenc subvis visibl particl mab formul pose signific challeng pharmaceut develop lead reduc shelf life batch reject recal among type particl proteinac particl concern due potenti role immunogen nevertheless under mechan protein particl format remain poor understood past research highlight import interfac mechan agit caus protein particl format current research suggest fatti acid impur present excipi result polysorb degrad also induc protein assembl promot particl format work assess oleic lauric acid impact particl format repres main hydrolysi product ps ps respect found co exist either fatti acid mgml mab caus protein particl similar morpholog observ previous mab formul ftir spectra show particl proteinac heterogen composit contain correspond fatti acid interest found oleic acid signific effect caus protein particl lauric acid experi suggest ps contain formul might lower likelihood protein particl compar ps contain mab formul hydrolysi polysorb occur last presenc polysorb mab formul abl fulli mitig effect fatti acid reduc protein particl signific suggest potenti mechan interfaci action involv present studi help understand root caus protein particl mab formul fatti acid introduc polysorb hydrolysi work help shed light product control strategi well design approach robust mab product | D005227;D011136 | T121;T109;T123;T168;T122 |
34,666,045 | mechanist model usp dissolut apparatus includ fluid hydrodynam sediment drug product dissolut key input physiolog base biopharmaceut model pbbm abl predict vivo dissolut integr product dissolut pbbms immedi releas drug product mechanist ie allow captur main determin vitro dissolut experi extract product batch specif paramet work focuss product particl size distribut p psd previous shown integr effect dose volum solubl ph size concentr micell calcul batch specif input pbbms propos new hydrodynam hd model integr effect usp apparatus paddl rotat speed medium viscos dissolut addit new model also propos estim quantit impact formul drug sediment cone dissolut model hdc predict cone presenc formul insolubl excipi hdc predict sediment drug substanc model parameter valid dissolut experi differ drug valid show hd model averag fold error afe dissolut rate predict immedi releas formul compris absolut averag fold error aaf compris show satisfactori predict power experi cone suspect hdc model improv precis predict defin ratio aaf valu fold compar hd model calcul p psd integr impact usp paddl rotat medium viscos cone improv pbbm predict sinc paramet could influenc vitro dissolut could open way better predict effect prandial state human exposur develop new silico tool could integr variat veloc profil due chyme viscos | D003198;D004304;D065546;D008962 | T066;T170;T122;T070;T062 |
34,666,044 | structur biochem character cysteinyl broad neutral antibodi hiv antibodi except breadth potenc elicit individu natur hiv infect elicit affin matur broad neutral antibodi bnab therefor central goal hiv vaccin develop function properti bnab also make attract immunotherapeut agent led product optim passiv immunotherapi process requir vitro manufactur monitor heterogen express especi subpopul antibodi produc vari level biolog activ post translat modif ptm antibodi contribut heterogen focus studi specif investig cysteinyl bnab lineag pcdn famili target n glycan supersit surfac envelop glycoprotein env hiv ptm defin cap unpair cystein residu molecular cystein chromatographi mass spectrometri abl character subpopul cysteinyl non cysteinyl antibodi express mammalian cell crystal structur two pcdn antibodi repres first structur cysteinyl antibodi reveal cysteinyl case locat cdrh biophys studi indic cysteinyl hiv antibodi interfer antigen bind report occur cysteinyl antibodi studi highlight need investig cysteinyl anti hiv bnab | D011499 | T044 |
34,666,043 | diverg dimer activ primat apobecc apobec famili singl strand dna cytidin deaminas host restrict factor inhibit lentivirus hiv absenc vif protein caus degrad deamin cytidin hiv dna form uracil caus inactiv mutat uracil use templat dna synthesi apobecc ac chimpanze gorilla orthologu activ human ac determin old world monkey ac rhesus macaqu rh activ hiv biochem virolog coevolutionari analys combin molecular dynam simul show key amino acid need promot rhac antivir activ also promot dimer chang dynam loop near enzym activ site although forc evolut rhac result similar dimer interfac hominid ac key amino acid contact differ overal result determin basi rhac less activ human ac establish amino acid network dimer increas activ base identif key amino acid determin old world monkey antivir activ predict old world monkey ac impart anti lentivir activ despit fixat key residu need hominid ac activ overal coevolutionari analysi ac dimer interfac present also provid basi analyz dimer interfac famili member | D019143;D015497;D055503 | T038;T005;T067 |
34,666,042 | panel engin ubiquitin variant target famili domain found ubiquitin specif proteas dusp domain found ubiquitin specif proteas dusp occur seven member ubiquitin specif proteas usp famili dusp defin distinct structur fold function remain larg unknown although studi usp suggest dusp enhanc deubiquitin activ use phage display librari ubiquitin variant ubv deriv protein base tool target dusp famili member high affin specif design ubv librari base insight structur previous identifi ubv bound dusp usp new librari yield uniqu ubv bound dusp five differ usp usp usp usp usp usp usp abl identifi least one dusp bound high affin absolut specif relat dusp show ubv target dusp usp usp usp inhibit catalyt activ enzym despit fact dusp locat outsid catalyt domain find provid altern mean inhibit usp activ target dusp mechan could potenti extend dusp contain usp | D020134 | T087;T169 |
34,666,041 | human ceacam lf regul lipid storag hepg cell via fatti acid transport cd carcinoembryon antigen relat cell adhes molecul ceacam express liver secret biliari glycoprotein bgp via bile canaliculi bcs ceacam lf amino acid cytoplasm domain mrna splice isoform two immunoreceptor tyrosin base inhibitori motif itim ceacam serala transgen mice shown develop insulin resist nonalcohol fatti liver diseas howev role human equival residu ser lipid dysregul unknown human hepg hepatocyt express ceacam form bc vitro compar ceacam cell ceacam cell express serala null serasp phosphoryl mimic mutat phosphoryl null mutat tyrosin itim known phosphoryl tyrosin kinas src ceacam cell serasp tyrph mutant strong retain lipid serala tyrph mutant low lipid level compar wild type cell indic itim mutant phenocopi ser mutant found fatti acid transport cd upregul sa mutant coexpress bcs ceacam co ipe ceacam src downregul via rnai increas lipid droplet content observ nuclear transloc cd associ kinas lkb increas sevenfold sa mutant versus ceacam cell correl increas activ cd associ kinas ampk ceacam cell thus ceacam hepg cell upregul lipid storag similar ceacam murin liver null mutat serala led decreas lipid storag emphas evolutionari chang ceacam gene mous human | D050356 | T044 |
34,666,035 | combin temporomandibular joint reconstruct patient fit total joint prosthesi orthognath surgeri reduc symptom juvenil idiopath arthriti patient patient juvenil idiopath arthriti jia tmj involv may major dentofaci deform pain jaw dysfunct aim studi evalu surgic outcom jia patient relat tmj pain headach jaw function diet disabl qualiti life qol tmj reconstruct patient fit total joint prosthes tjp concomit orthognath surgeri | D001171;D007595;D057909;D013705 | T091;T074;T047 |
34,666,033 | sever atroph mandibl restor fiber reinforc composit prosthes support mm ultra short implant present high surviv rate eight year encourag result report ultrashort singl implant howev long term investig warrant full arch reconstruct studi evalu margin bone loss implant reconstruct surviv fiber reinforc composit full arch prosthes support ultrashort implant | D016301;D000540;D015921 | T074;T047;T061 |
34,666,032 | novel variant osgep lead galloway mowat syndrom alter subcellular local galloway mowat syndrom gamo extrem rare clinic heterogen autosom x link inherit recess diseas character earli onset steroid resist nephrot syndrom srns microcephali neurolog impair studi two sibl main present decreas head circumfer hypotonia gross motor delay dysmorph featur initi detect without pathogen variant karyotyp snp array wes year follow proband manifest addit proteinuria hematuria deeper sulci sign brain atrophi reanalysi proband previous wes data two novel compound heterozyg variant osgep cdupa cc identifi furthermor function studi show variant reduc express osgep protein activ dna damag respons ddr signal lymphoblastoid cell line lcls obtain patient analysi protein local confoc microscopi reveal egfp taggedha tag mutant osgep protein abnorm aggreg retain insid cytosol respect studi expand pathogen variant spectrum osgep also carri regular follow kidney involv establish strategi evalu function mutant osgfp subcellular local assay | D006551;D008831;D009401;D009404 | T047;T019 |
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