PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,666,031 | sestrin atherosclerosi atherosclerosi patholog basi numer lethal diseas myocardi infarct heart failur stroke know almost twenti million peopl worldwid die arteri diseas annual sestrin stress induc protein serv guardian activ ampk inhibit mtor maintain redox balanc beneath various stress environ larg number studi show sestrin would shield bodi injuri stress moreov demonstr sestrin close connect articl review involv sestrin pathogenesi four aspect cellular mechan oxid stress inflamm lipid metabol current evid reveal sestrin novel target prevent treatment | D050197;D009203 | T047;T046 |
34,666,030 | exosom nasopharyng carcinoma nasopharyng carcinoma npc malign epitheli tumor uniqu geograph distribut primarili preval east africa asia although increas understand pathogenesi risk factor npc prevent treatment effort remain limit various studi indic exosom activ involv npc deliv biomolecul non code rnas protein target cell review summar biolog function exosom npc highlight prospect diagnost biomark npc exosom manipul tumor microenviron particip chemotherapi radiat resist induc immun suppress promot patholog angiogenesi support metastasi thus could also promis biomark exosom essenti effect unusu biolog properti promis futur diagnost monitor prognost evalu although technic issu associ use exosom larg scale applic unparallel advantag assist clinic manag npc | D002277;D055354;D009303 | T026;T191 |
34,666,029 | determin th th percentil upper refer limit heart type fatti acid bind protein h fabp us popul heart type fatti acid bind protein h fabp low molecular weight protein found primarili myocardi tissu identifi potenti biomark detect acut coronari syndrom acut kidney injuri investig clinic util sought establish upper refer limit url h fabp within healthi us | D009206 | T024 |
34,666,028 | urinari neutrophil gelatinas associ lipocalin acut kidney injuri liver cirrhosi acut kidney injuri aki liver cirrhosi associ poor clinic outcom includ increas long short term mortal common type aki observ patient cirrhosi preren aki pra hepatoren syndrom hrs acut tubular necrosi atn despit grow knowledg uniform definit diagnosi aki sever challeng includ earli diagnosi manag precis differenti type aki critic therapi differ signific review summar aki liver cirrhosi definit pathophysiolog defici use exist biomark serum creatinin outlin current clinic evid novel biomark urinari neutrophil gelatinas associ lipocalin ungal potenti role biomark earli detect differenti prognost aki review also briefli talk forthcom biomark hold promis manag aki liver cirrhosi | D058186 | T047;T037 |
34,666,027 | urinari podocyt marker kidney diseas podocyt play import role mainten kidney function primari focus mani kidney diseas podocyt injuri result shed podocyt deriv cellular fragment podocyt specif molecular target urin may serv biomark kidney diseas intact podocyt either viabl dead podocyt deriv microvesicl could quantifi urin various centrifug visual cultur method podocyt specif protein target nucleus cytoplasm slit diaphragm glomerular capillari basement membran cytoskeleton well correspond messeng rna mrna urin could quantifi western blot elisa quantit polymeras chain reaction although techniqu may expens labor intens present may becom wide avail futur improv technolog autom applic urinari podocyt marker diagnosi monitor various kidney diseas explor publish data area suffici systemat lack extern valid research focus standard compar autom laboratori method well defin ad valu routin clinic test | D007674;D050199 | T025;T047 |
34,666,026 | set analyt perform specif use hbac model measurand analyt perform specif ap measurand describ minimum analyt qualiti requir measur ap use monitor contain systemat truenessbia random error precisionimprecis laboratori measur ensur result fit purpos inform clinic decis manag patient health condit review highlight wide variat set ap use differ level evid recommend milan consensus approach set priori defin outcom base ap hbac remain challeng promis indirect altern seek link clinic util hbac ap defin statist confid interpret laboratori valu simul clinic perform vari level analyt perform ap defin base biolog variat estim healthi individu use current formula unachiev near routin laboratori method hbac test hand ap employ extern qualiti assur program progress tighten great facilit improv qualiti hbac test laboratori select ap fit intend clinic use document data rational underpin select possibl common ap adopt across region countri facilit movement patient patient data across health care facil | D007753 | T093;T073 |
34,666,025 | gut microbiom metabol respons non alcohol fatti liver diseas fatti liver diseas fld one largest burden human health worldwid associ gut microbiom metabolit stabil engin liver tissu shown promis restor liver function non alcohol fld nafld hepat cirrhosi fatti liver larg note obes hepat cancer high fatal led global increas death rate associ complex metabol reprogram standard approach therapi newli diagnos set includ surgeri identif biomark metabolit therapeut purpos ultim focus improv liver health patient standard procedur patient care depend sever system therapi either genom proteom metabolom profil form potenti option better comparison studi under mechan gut microbiom base metabol function obes urgent requir today emerg field focus metabolom approach metabol phenotyp involv high throughput identif metabolom obes gut disord involv biomark metabolit identif support technolog approach nafld throw light metabolit gut microbiom also understand risk factor obes along liver cancer metabol reaction network discuss current state nafld metabolit gut micro environment chang challeng digit metabolom profil innov clinic trial design biomark enrich strategi requir improv outcom nafld patient also discuss | D000069196;D065626 | T007;T047;T001 |
34,666,024 | transcript epigenet regul tempor pattern neural progenitor develop neural progenitor undergo tempor pattern age sequenti generat differ fate progeni tempor pattern neural progenitor relat well studi drosophila tempor cascad transcript factor oppos tempor gradient rna bind protein express neural progenitor age control fate progeni tempor progress most driven intrins mechan includ cross regul tempor gene environment cue also play import role certain transit vertebr neural progenitor demonstr greater plastic respons extrins cue recent studi suggest vertebr neural progenitor also tempor pattern combin transcript post transcript mechan respons extracellular signal regul neural fate specif review summar recent advanc studi tempor pattern neural progenitor drosophila vertebr also discuss involv epigenet mechan specif polycomb group complex atp depend chromatin remodel complex tempor pattern neural progenitor | D044127;D018507;D055495;D015398 | T040;T044;T043;T045 |
34,666,023 | corpuscl stannius develop requir fgf signal corpuscl stannius cs repres uniqu endocrin organ teleostean fish secret stanniocalcin stc maintain calcium homeostasi appear somit stage distal zebrafish pronephro stc express cell undergo apic constrict subsequ extrud form distinct gland top distal pronephr tubul h post fertil hpf sever transcript factor eg hnfb irxb tbxab signal pathway eg notch control cs develop report fgf signal requir commit tubular epitheli cell differenti stc express cs cell inhibit fgf signal su domin negat fgfr deplet fgfa prevent cs format stc express ablat experi reveal cs abil partial regener via activ cell migrat involv extens filopodia lamellipodia format activ wnt signal curtail stc express effect cs format thus observ identifi fgf signal crucial compon cs cell fate commit | D002454;D005346;D060449;D015027;D029961 | T044;T116;T123;T043;T013 |
34,666,018 | volatil organ compound second hand smoke may increas suscept children oxid stress damag although human general expos second hand smoke shs volatil organ compound voc exposur deriv shs health hazard non smoker rare investig thus examin effect shs voc exposur oxid stress damag via passiv smoke simul experi children adult valid studi urinari voc metabolit biomark passiv smoke children recruit level hydroxi deoxyguanosin ohdg malonaldehyd mda tran hydroxycotinin oh cot voc metabolit urin determin result show geomean concentr voc metabolit urin children higher adult passiv smoke level urinari ohdg mda oh cot increas children adult respect therefor children vulner shs adult exposur shs level urinari voc metabolit benzen acrylonitril bromopropan propylen oxid toluen methyl methacryl cyanid increas within h voc metabolit also signific associ ohdg mda urin p therefor exposur voc caus shs increas bodi oxid stress damag oh cot level higher gg cr use threshold passiv smoke level urinari benzylmercaptur acid bma phenylmercaptur acid pma children increas within h passiv smoke respect popul valid studi indic bma pma level signific elev children expos shs therefor addit oh cot urinari bma pma potenti use short term biomark passiv smoke futur studi focus differ voc metabol detoxif mechan children adult | D014028;D055549 | T033;T069;T109 |
34,666,017 | analysi vulner heat rural urban area spain factor explain heat geograph behavior current littl knowledg publish work subject vulner heat rural environ countri level therefor object studi determin whether rural area vulner extrem heat urban area spain studi aim analyz whether pattern vulner depend contextu environment demograph econom hous variabl | D055874;D006358 | T033;T070 |
34,666,016 | innov regulatori approach endocrin disrupt chemic journey risk assess modern canada global regulatori author grappl challeng assess hazard risk human ecosystem health may result exposur chemic disrupt normal function endocrin system rapid increas number chemic commerc coupl relianc tradit cost anim experi hazard character often limit sensit mani import mechan endocrin disrupt present ongo challeng chemic regul consequ limit number chemic suffici data assess endocrin toxic henc chemic thorough hazard character address challeng regulatori assess endocrin disrupt chemic edc benefit revolut toxicolog focus new approach methodolog nam rapid identifi priorit assess potenti risk exposur chemic use novel effici mechanist driven methodolog tool incorpor integr approach test assess iata guid conceptu framework advers outcom pathway aop emerg approach focus initi molecular interact test chemic potenti vulner biolog system instead need anim toxic data new toxic test method complement silico comput toxicolog approach includ predict chemic kinet coupl exposur data inform risk base decis make approach canada part global network collabor build confid use nam regulatori assess edc herein review current approach edc regul global main perspect human health provid perspect advanc regulatori test assess appli discuss promis challeng face adopt novel approach minim risk due edc exposur canada world | D052244 | T131;T039 |
34,666,015 | genet test famili hypercholesterolemia past present futur earli nobel prize win cellular molecular work mike brown joe goldstein led identif ldl receptor gene first gene mutat caus famili hypercholesterolemia fh phenotyp know autosom domin monogen fh caus pathogen variant three addit gene apobpcskapo plasma ldl c concentr risk prematur coronari heart diseas differ accord specif locus associ molecular caus possibl use next generat sequenc sequenc exon four gene process patient sampl one sequenc run increas speed test result reduc cost result identif mani novel fh caus variant also variant unknown signific requir evid classifi pathogen benign identif fh caus variant index case use unambigu rapid test famili member fh caus variant found patient fh phenotyp appreci major patient without monogen caus polygen etiolog phenotyp high like compar monogen caus patient signific lower risk futur coronari heart diseas use molecular genet diagnost method character fh prime exampl util precis person medicin | D005820 | T059;T060 |
34,666,014 | distal versus convent radial access coronari angiographi intervent design rational disco radial studi transradi access tra becom default access method coronari diagnost intervent procedur compar transfemor access tra shown safer cost effect patient friend radial arteri occlus rao repres frequent complic tra preclud futur coronari procedur radial arteri use radial arteri conduit coronari arteri bypass graft arterioven fistula patient hemodialysi recent distal radial access dra emerg promis altern tra yield potenti minim risk rao howev intern multicent random comparison dra convent tra respect rate rao still lack | D001157;D062645 | T047;T061 |
34,666,013 | incid rate predictor microvascular macrovascular complic patient type diabet result longitudin global discov studi micro macrovascular complic major caus morbid mortal peopl type diabet td sought understand global incid rate predictor complic | D003924;D003925 | T047 |
34,666,012 | electr cardiovers atrial fibril risk bradi arrhythm event electr cardiovers ecv common procedur termin atrial fibril af ecv associ bradi arrhythm event howev age specif risk clinic signific bradi arrhythm event unknown | D001281;D006333 | T047;T046 |
34,666,011 | lung respons higher posit end expiratori pressur mechan ventil patient covid intern guidelin suggest use higher cm h posit end expiratori pressur peep patient moder sever ard due covid howev even oxygen general improv higher peep complianc paco frequent recruit small | D000086382;D012128 | T047;T067 |
34,666,008 | high sensit photometr micropl assay tumor necrosi factor alpha base fe bc nanozym optic immunoassay detect protein biomark tumor necrosi factor tnf report base core shell fe bc structur nanozym label nanozym compos fe nanoparticl core carbon layer shell element b dope carbon shell nanozym display good peroxidas like activ oxid tetramethylbenzidin tmb oxtmb presenc h generat blue color compound detect tnf follow elisa protocol replac tradit enzym horseradish peroxidas hrp nanozym fe bc assay finish h wide linear rang tnf pgml ngml limit detect pgml assay appli detect tnf human serum sampl detect result compar commerci elisa | D004797;D010783 | T059 |
34,666,007 | multiom profil liver across diet age divers mous popul profil liver transcriptom proteom metabolom individu isogen strain bxd mous popul across age month diet low high fat link molecular variat metabol trait sever hundr gene affect diet andor age transcript protein level ortholog two age associ gene st ctsd knock c elegan reduc longev wild type mutant long live strain multiom data analyz segreg gene network accord independ variabl provid causal insight dietari age effect candid cross examin independ divers outbr mous liver dataset segreg similar diet diet relat candid gene found common across dataset togeth develop larg multiom resourc multivari analysi complex trait demonstr methodolog move observ associ causal connect | D017173;D008099 | T204;T023 |
34,666,006 | control hormon driven organ disassembl ecm remodel yorki depend apoptosi epithelia grow shape function structur organogenesi although focus organogenesi drawn build biolog structur disassembl pre exist structur also import event reach function adult organ exampl disassembl process includ regress mllerian wolffian duct gonad develop mammari gland involut post lactat period adult femal date unclear organ disassembl control cellular level follow drosophila larval trachea metamorphosi show disassembl hormon driven precis orchestr process occur two phase first remodel apic extracellular matrix aecm mediat matrix metalloproteas independ actomyosin cytoskeleton result progress shorten entir trachea nuclear cytoplasm reloc hippo effector yorki yki second decreas transcript yki target diap posterior metamer activ caspas result apoptot loss posterior half trachea anterior half escap cell death thus work unravel mechan hormon driven ecm remodel control sequenti tissu shorten apoptot cell remov transcript activ yki lead organ disassembl anim develop | D029721 | T116;T123 |
34,666,005 | plastin spectrin cooper stabil actomyosin cortex cytokinesi cytokinesi process partit mother cell two daughter cell requir assembl constrict equatori actomyosin network differ type non motor f actin crosslink local network function contribut remain poor understood describ synergi small rigid crosslink plastin larg flexibl crosslink spectrin c elegan one cell embryo contrast singl inhibit co inhibit plastin h spectrin sma result cytokinesi failur due progress disorgan eventu collaps equatori actomyosin network cortic local dynam non muscl myosin ii co inhibit embryo mimic observ drug induc f actin depolymer suggest combin action plastin spectrin stabil f actin contractil ring silico model predict spectrin effici plastin stabil ring ring format relat insensit h spectrin length confirm vivo sma mutant lack spectrin repeat find provid first evid spectrin contribut cytokinesi highlight import crosslink interplay actomyosin network integr | D000205;D048749 | T043;T116;T123 |
34,666,004 | border famili negat transcript elong factor regul flower time arabidopsi transcript initi long consid primari regulatori step gene express recent work howev show downstream event transcript elong also play import role well character exampl anim promot proxim paus transcript engag pol ii accumul bp downstream transcript start site tss thought enabl rapid gene activ plant make widespread use promot proxim paus howev phenomenon known paus signific increas pol ii observ near transcript end site tes mani gene previous work shown paus promot border bdr famili negat transcript elong factor show bdr protein play key role gene repress consist bdr protein act slow paus elong pol ii bdr repress gene character high level pol ii occup yet low level mrna bdr protein physic interact fpa one approxim two dozen gene collect refer autonom floral promot pathway necessari repress flower time gene flower locus c flc earli flower strain flc express repress repress histon modif histon h lysin trimethyl hkme therebi allow plant flower earli result suggest repress transcript elong bdr protein may allow temporari paus transcript facilit long term repress gene repress histon modif | D017360;D029681 | T116;T002 |
34,666,003 | viral histon like protein exploit antagon linker histon hmgb protein obstruct cell cycl virus infect necessarili requir redirect cellular resourc toward viral progeni product adenovirus encod histon like protein vii caus catastroph global reorgan host chromatin promot virus infect protein vii recruit famili high mobil group box hmgb protein chromatin along histon chaperon set consequ recruit find protein vii caus chromatin deplet sever linker histon h isoform relationship linker histon h function opposit hmgb protein critic higher order chromatin structur howev physiolog consequ perturb relationship larg unknown employ complementari system saccharomyc cerevisia human cell demonstr adenovirus protein vii disrupt h hmgb balanc obstruct cell cycl find protein vii caus accumul gm cell yeast human system underscor high conserv chromatin vulner contrast adenovirus ea eb protein well establish overrid cell cycl regul promot transform human cell strike find protein vii obstruct cell cycl even presenc ea eb show protein vii delet infect sever cell cycl marker regul differ compar wild type infect support model protein vii play integr role hijack cell cycl regul infect togeth result demonstr protein vii target h hmgb antagon obstruct cell cycl progress reveal unexpect chromatin vulner exploit viral benefit | D024002;D006657 | T116;T123 |
34,666,002 | electr coupl pioneer circuit enabl motor develop via propriocept feedback drosophila embryo precoci movement wide seen embryo various anim speci whether movement via propriocept feedback play instruct role motor develop mere reflect activ immatur motor circuit long stand question imag emerg motor activ drosophila embryo lack propriocept feedback show propriocept experi essenti develop locomotor central pattern generat cpgs downstream propriocept input identifi pioneer premotor circuit compos two pair segment interneuron whose gap junction transmiss requir propriocept experi play crucial role cpg format circuit autonom generat rhythmic plateau potenti via ip mediat ca releas intern store contribut muscl contract henc produc propriocept feedback find demonstr import self generat movement instruct motor develop identifi cell circuit physiolog core propriocept feedback | D004330;D056228 | T204;T041;T067 |
34,666,000 | yap inhibit promot endotheli cell differenti pluripot stem cell ec master transcript factor fli endotheli cell ec deriv pluripot stem cell pscs provid great resourc vascular diseas model cell base regener therapi howev molecular mechan ec differenti complet understood studi check transcript profil microarray found hippo pathway chang activ yap decreas mesoderm mediat ec differenti human embryon stem cell hesc knockdown yap hesc promot mesoderm ec differenti indic mesoderm ec specif marker gene express increas mrna protein level contrast overexpress yap inhibit mesoderm ec differenti microarray data show sever key transcript factor ec differenti fli erg sox upregul interest knockdown yap enhanc express master transcript factor bioinform analysi reveal tead yap bind transcript factor might regul express ec master tfs includ fli luciferas assay confirm yap bind tead would inhibit fli express final fli overexpress rescu effect yap overexpress mediat inhibit ec differenti conclus reveal inhibitori effect yap ec differenti pscs yap inhibit might promot express master tfs fli ec commit interact tead might provid idea ec differenti vascular regener via manipul yap signal | D000066449;D039904 | T025 |
34,665,999 | high order interact explain collect behavior cortic popul execut sensori area one influenti view neurosci pairwis cell interact explain fire pattern larg popul despit preval view origin studi retina visual cortex anesthet anim whether pairwis interact predict fire pattern neuron across multipl brain area behav anim remain unknown perform multi area electr record find nd order interact explain high fraction entropi popul respons macaqu cortic area v v surpris despit brain state modul neuron respons model base pairwis interact captur spike activ structur wake sleep howev regardless brain state pairwis interact fail explain experiment observ entropi neural popul prefront cortex thus simpl pairwis interact explain collect behavior visual cortic network across brain state explain popul dynam downstream area involv higher order interact | D000090522;D014793 | T023;T029;T054 |
34,665,998 | post translat regul membran transport contribut salt toler plant review articl summaris role membran transport regulatori kinas minimis toxic na plant salt stress salt toler plant keep cytosol level na mm first line action context generat proton motiv forc plasma membran h atpas generat proton motiv forc repolaris membran get depolaris due passiv uptak na salt stress proton motiv forc generat also drive plasma membran nah antiport sos efflux cytosol na back environ intracellular level na sequest vacuol vacuolar na uptak mediat nah antiport nhx driven electrochem gradient h generat tonoplast h pump hatpas ppase howev express regulatori kinas make transport activ post translat modif enabl effect manag cytosol level na essenti toler salin plant yet knowledg express function regulatori kinas plant speci differ toler salin scant bioinformat base identif kinas like oscipk crop plant most salt sensit may enabl biotechnolog intervent make crop cultivar salt toler effect increas annual yield | D026901;D055049 | T040;T116;T126;T123 |
34,665,997 | health qualiti life outcom drive cessat older peopl complex thought studi examin whether meaning subgroup older past driver experi better health qualiti life outcom factor may contribut outcom | D001334;D011788 | T056;T078 |
34,665,996 | seven week gait retrain minimalist footwear effect dynam stabil compar convent footwear purpos investig effect two differ run footwear condit transit minimalist footwear convent run footwear dynam postur stabil week gait retrain program evalu effect fatigu dynam stabil method random control clinic trial carri recreat male runner random divid two group convent footwear group cfg n minimalist footwear group mfg n dynam postur stabil index dpsi fatigu non fatigu state assess gait retrain program gait retrain program consist three guid train session per week week train program main focus run techniqu submaxim aerob train step frequenc exercis minimalist footwear progress introduc mfg cfg mfg perform train exercis full bodi condit program fatigu induc use minut run test individu maxim aerob speed result differ dynam stabil variabl found mfg cfg studi condit mfg cfg show better dynam stabil intervent program cfg chang dpsipr dpsipost p mfg chang dpsipr dpsipost final dynam stabil signif lower group fatigu protocol p conclus follow week gait retrain program footwear affect result gait retrain program relev improv dynam stabil | D012420;D012775 | T073;T056 |
34,665,995 | design valid tactic assess instrument footbal tai focus tactic made assess difficult due lack knowledg topic limit current tactic assess instrument purpos design valid tactic assess instrument youth footbal tai follow exhaust ecolog meticul process deal limit found literatur method design divid two stage relat develop valid develop stage preliminari list criteria determin literatur review b criteria delimit exploratori observ c adequaci criteria determin consult expert valid stage content comprehens valid obtain consult expert systemat game observ b construct valid obtain compar tactic outcom two group differ skill level c criterion valid establish compar tactic outcom use game perform assess instrument present instrument reliabl obtain inter rater reliabl result research process show instrument valid reliabl tool compris criteria assess tactic outcom year old youth footbal conclus tai present sever advantag practic term respect assess first allow assess three tactic level nest unit observ second consid player role third result present without general index fourth use assess particip institut context final includ contextu variabl | D054874;D005538;D012916 | T056;T055 |
34,665,994 | retrospect analysi adher hiv treatment healthcar util commerci insur popul singl tablet regimen strs improv antiretrovir therapi art adher howev relationship long term adher patient healthcar resourc util hru unclear object studi assess long term art adher among peopl live hiv plhiv use strs multi tablet regimen mtrs compar hru time adher | D019380;D015658 | T047;T121 |
34,665,993 | factor associ pediatr vaccin hesit parent cross section studi turkey aim studi aim determin preval associ factor vaccin hesit femal children age month year receiv servic antenat class tertiari hospit turkey method studi group includ parent receiv servic tertiari hospit data collect tool studi descript data form parent attitud childhood vaccin surveyth data analyz use chi squar analysi logist regress analysi result studi preval vaccin hesit determin vaccin refus preval univari analysi vaccin hesit found signific higher mother univers educ got pregnant treatment train pediatr vaccin antenat follow follow anti vaccin group social media use vitamin iron supplement regular never use child vaccin hesit signific higher parent state inform sourc vaccin scientif worri vaccin ingredi aluminum mercuri pig gelatin use altern medicin practic p multivari analysi risk vaccin hesit increas time pregnanc treatment time use vitamin iron prepar time follow anti vaccin group social media time parent worri vaccin ingredi conclus find suggest preval vaccin hesit risk factor monitor close follow year | D014611;D014612 | T129;T121;T116;T061 |
34,665,992 | fli bat use serial sampl locat odour sourc olfactori track general sacrific speed sensit fast move anim appear surpris effici forag smell analys olfactori track strategi fli bat forag fruit fruit nectar feed bat use odour cue find food despit sensori challeng deriv fast flight speed echoloc train jamaican fruit eat bat artibeus jamaicensi locat odour reward reconstruct flight path three dimension space result confirm bat reli upon olfactori cue locat reward flight path reveal combin odour memori guid search strategi inspect flight bat signific reduc flight speed flew within approxim cm possibl target evalu presenc absenc odour cue behaviour combin echoloc explain bat maxim forag effici compens trade off associ olfactori detect locomot | D002685;D004455 | T040;T015 |
34,665,991 | longitudin evid older parent produc offspr longer telomer wild social bird telomer length tl often predict surviv lifespan consider interest origin inter individu variat tl cross generat effect parent age offspr tl thought key sourc variat rariti longitudin studi examin telomer success offspr born throughout live parent leav effect poor understood exploit tl measur success offspr produc throughout long breed tenur parent wild white brow sparrow weaver plocepass mahali societi isol effect within parent chang age offspr tls analys reveal first evid date posit within parent effect advanc age offspr tl individu parent age produc offspr longer telomer modest effect persist offspr adulthood consid potenti pre post natal mechan explain find telomer attrit predict offspr surviv adulthood speci posit parent age effect could impact parent offspr fit aros via differenti telomer attrit offspr develop find support view cross generat effect parent age sourc inter individu variat tl | D046370;D016615 | T026;T012 |
34,665,990 | long term trend occup ant reveal use multi sourc dataset combin participatori scienc data museum record understand long term chang occup ant speci denmark year bayesian occup model indic chang occup speci five increas four declin six show fluctuat trend consid trend may influenc life histori habitat chang result build emerg pictur biodivers chang insect complex impli simpl insect declin narrat | D001000 | T204 |
34,665,989 | outcom pediatr germ cell tumor comparison carboplatin cisplatin base regimen year analysi carboplatin advoc frequent treatment childhood germ cell tumor gct due less long term toxic demonstr equival outcom compar cisplatin analysi present surviv gct low middl incom countri compar two differ chemotherapeut regimen retrospect analysi patient case record carri year januari decemb chemotherapi regimen use bleomycin etoposid cisplatin peb initi year carboplatin etoposid bleomycin ceb subsequ nineti patient gct treat year malign gct diagnos patient teratoma chemotherapi protocol peb ceb patient patient treat surgeri stage tumor observ patient relaps diseas progress seen overal event free surviv year entir cohort similar peb os ef vs ceb os ef signific better overal surviv note patient gonad gct non stage diseas event free surviv signific better patient non stage diseas chemotherapeut regimen peb vs ceb high afp valu iul risk stratif low intermedi high risk diseas affect surviv signific carboplatin base strategi equival cohort cisplatin base strategi could use safe lmic set overal surviv suboptim delay present abandon relaps barrier surviv | D009373;D013736 | T191 |
34,665,988 | autograft versus allograft evid hip labral reconstruct augment labral augment labral reconstruct emerg essenti procedur restor anatom function characterist hip joint patient defici hip labrum irrepar labral tear | D000203;D006621 | T080;T030;T056 |
34,665,987 | abcc itpa nudt tpmt interact genet predictor mercaptopurin intoler chines patient acut lymphoblast leukemia inter individu varianc mercaptopurin mp dose intens common patient acut lymphoblast leukemia aim evalu associ common variant abcc itpa nudt tpmt mp dose intens toxic pediatr patient cohort patient intoler mp actual dosag less schedul dose twenti percent patient found heterozyg homozyg mutat nudt nudt cc genotyp predict nudt activ signific associ mp intoler tpmt c variant common cohort nudt polymorph genotyp predict nudt activ signific associ mp dose intens leukopenia episod combin abcc itpa variant abcc cg itpa cc also show signific posit associ mp intoler chines children studi pharmacogenet screen patient avoid mp induc toxic recommendedsupplement data articl avail onlin https doiorg | D000964;D015122;D054198 | T191;T121;T114 |
34,665,984 | brief review current knowledg environment toxic risk pediatr cancer incid pediatr cancer steadili increas sinc could suggest exogen factor account increas proport case grow concern environment exposur ie toxic develop pediatr cancer howev identifi environment exposur childhood cancer risk challeng outcom infrequ compar cancer adult difficult estim exposur specif critic period develop eg pre concept utero earli childhood like import childhood cancer develop summar intern agenc research cancer iarc group agent toxic known carcinogen human rout exposur current method risk mitig known associ pediatr cancer risk review suggest environment toxic import potenti modifi risk factor need fulli explor children adolesc | D015386;D009369 | T131;T191 |
34,665,980 | effect sex land task hip mechan preval femoroacetabular imping syndrom common cut sport first step understand relationship cut sport develop femoroacetabular imping investig hip joint contact forc task purpos studi explor sex task differ hip joint contact forc estim musculoskelet model singl leg drop land land cut kinemat ground reaction forc obtain adult perform drop land land cut task simul perform opensim estim lower extrem muscl forc hip joint contact forc statist parametr map use compar hip joint forc waveform sex task sex differ hip joint forc land trial character increas hip joint forc compar land cut trial hip joint forc estim obtain current studi could use futur finit element model incorpor bone growth model understand develop femoroacetabular imping design possibl compensatori exercis | D057925;D013177 | T046;T056 |
34,665,978 | impact rheotaxi flow aggreg organ dispers popul often need organ group chemic attract provid one mean direct individu aggreg whether structur emerg depend various factor suffici larg popul respons attract suffici sensit aquat environ fluid flow may heavili impact popul distribut mani aquat organ adopt rheotaxi respons expos current orient swim accord flow field consequ flow induc transport could substanti differ popul member aggreg signal secret aim investig flow rheotaxi respons impact aquat popul abil form maintain aggreg profil develop analys mathemat model incorpor factor systemat analysi effect introduc rheotact behaviour various form environment flow demonstr flow rheotaxi act benefici detriment abil form maintain cluster synthes find test hypothesi densiti depend rheotaxi may optim group format mainten individu increas rheotact effort approach aggreg state | D059001;D013550 | T001;T056 |
34,665,977 | two class function connect dynam process network relationship network structur dynam one extens investig problem theori complex system recent year understand relationship relev rang disciplin neurosci geomorpholog major strategi investig relationship quantit comparison represent network architectur structur connect sc network represent dynam function connect fc show one distinguish two class function connect one base simultan activ co activ node base sequenti activ node delin two class differ categori dynam process excit regular chaotic oscil provid exampl scfc correl class model expand theoret view scfc relationship conceptu instanc sc two class fc various applic scenario geomorpholog ecolog system biolog neurosci socio ecolog system see organis dynam process network either govern co activ sequenti activ allow us bring order myriad observ relat structur function complex network | D004463;D017753 | T070;T082;T090 |
34,665,976 | impact rheolog properti bacteri streamer format bacteri biofilm found wherev water substrat caus chronic infect clog industri flow system despit intens investig dynam rheolog properti biofilm impact rheolog properti streamer growth remain unknown numer simul biofilm growth pillar flow investig effect rheolog properti filament flow shape biofilm call streamer format vari viscoelast flow field assum stoke flow solv boundari element method maxwel model use extracellular matrix mediat streamer growth express fluiditi streamer format high elast modulus viscos need streamer format high viscos promot streamer growth low cell concentr find consist experiment observ explain relationship cell concentr viscos streamer form | D001419;D018441 | T007 |
34,665,975 | collect effect finit size inhomogen spatial spread popul two dimens dynam popul expand unoccupi habitat primarili studi situat growth dispers paramet uniform space vari one dimens studi influenc finit size individu inhomogen collect effect front speed random place two dimension habitat use individu base model investig front dynam region dispers growth individu reduc zero obstacl increas background hotspot respect regim front dynam determin local front speed principl least time employ predict front speed shape result analyt solut motiv event base algorithm illustr effect sever obstacl hotspot final appli principl least time larg heterogen environ solv eikon equat numer obstacl lead slow domin number densiti width obstacl precis shape hotspot result speed character function hotspot strength densiti find emphas import take dimension environ account | D017753 | T070;T082 |
34,665,974 | network analysi intra interspecif freshwat fish interact use year around track long term yet detail view social pattern aquat anim elus advanc realiti mine track technolog proxim base social network pbsn captur detail spatio tempor underwat interact collect analys larg dataset freshwat fish four speci track everi second year natur environ calcul cluster coeffici minut minut pbsns measur social interact happen among fish share resourc habitat prefer positiveneutr interact predat prey forag interact agonist interact statist signific coeffici compar equival random network suggest interact signific aggreg cluster across pbsns indic prolong purpos social behaviour carp cyprinus carpio display within among speci interact especi day winter tench tinca tinca catfish silurus glani solitari perch perca fluviatili exhibit signific social behaviour except autumn despit usual describ predat use social facilit increas prey intak work illustr method build pbsn affect network structur highlight challeng eg miss signal differ burst frequenc deriv pbsn realiti mine technolog | D002347;D010471 | T013 |
34,665,973 | flight effici key divers wing morpholog small insect insect wing hybrid structur typic compos vein solid membran smallest fli insect howev wing membran replac hair like bristl attach solid root bristl membran wing surfac coexist small larg insect speci satisfi explan find aerodynam forc product alway smaller bristl solid wing comput studi suggest divers wing structur small insect result aerodynam effici rather requir produc elev forc flight test wing vari fulli membran spars bristl flap around wing root lift drag base wing kinemat pattern differ reynold number result show decreas aerodynam effici decreas surfac solid signific smaller replac wing membran bristl thus caus less chang energet cost flight small compar larg insect consequ small insect may fli bristl solid wing surfac similar efficaci larger insect must use membran wing effici product flight forc find signific biolog fit dispers insect fli elev energi expenditur | D005426;D008954 | T040;T075 |
34,665,971 | protect effect apelin cardioren toxic induc cyclophosphamid cyclophosphamid chemotherapeut drug wide use clinic caus multi organ toxic apelin endogen adipocytokin antioxid properti therefor studi investig possibl apelin potenti therapeut agent cardiac toxic nephrotox caus cyclophosphamid studi total four group form eight rat group group control group administ salin ip group ii cyclophosphamid singl dose mgkg ip day group iii apelin gkg day ip group iv administ apelin gkg ip day singl dose cyclophosphamid mgkg ip day rat sacrif day lactat dehydrogenas cardiac troponin ctni creatin kinas mb ck mb aspart aminotransferas ast alanin aminotransferas alt alkalin phosphatas alp malondialdehyd creatinin blood urea nitrogen found high cyclophosphamid group howev valu reduc apelin administr antioxid enzym superoxid dismutas sod glutathion peroxidas gpx catalas reduc glutathion gsh decreas cyclophosphamid group apelin increas enzym activ addit histopatholog examin also support result obtain find studi show apelin protect effect cardioren toxic caus cyclophosphamid | D066126;D036341 | T116;T037;T123 |
34,665,970 | mathemat model drug diffus multi layer capsulestablet drug deliveri devic paper two mathemat model formul extend basic reaction diffus model along suitabl initi boundari condit studi drug deliveri diffus biolog tissu multi layer capsulestablet drug deliveri devic ddds respect devic either taken oral drug administr rout formul model solv use variat finit element method follow fundament matrix method studi drug deliveri diffus effici main aim work provid effect model use optim mathemat techniqu help research biologist medicin decreas endeavour expens design ddds outcom obtain compar experiment data demonstr valid feasibl propos work | D016503;D008962 | T062;T074;T170 |
34,665,967 | return invest analysi impact jame cook univers medic student rural workforc result particip extend rural placement although medic student jame cook univers jcu queensland australia undertak rural placement throughout cours proport current per year final year student undertak extend rural placement rural remot town month integr rural placement irp month longitudin integr clerkship lic program studi use return invest roi approach quantifi student rural medic workforc benefit aris extend placement | D019035;D013337 | T058;T097;T093;T073 |
34,665,966 | azoresdiab model risk predict type diabet azor incid type diabet mellitus increas azor azorean popul uniqu health relat characterist emphas necess develop predict model name doubl insular phenomena consanguin marriag therefor author aim develop model azoresdiab model assess risk type diabet resid azor | D003924 | T047 |
34,665,963 | screen quantif encapsul dye supramolecular particl encapsul therapeut agent drug vaccin colloid particl offer attract strategi enhanc efficaci previous report develop guanosin base supramolecular colloid particl suitabl encapsul broad array guest rang small molecul drug like doxorubicin protein like gfp mani biomed applic particl requir precis determin amount encapsul therapeut agent despit mani studi describ develop particl base deliveri system general method precis quick quantif encapsul payload still lack report method base flow cytometri measur complex made guanosin base particl varieti commerci avail fluoresc dye method allow us determin appar affin dye two variant particl turn provid insight structur affin relationship contrast current method reli fluoresc microscopi base measur absorptionfluoresc dissolv particl supernat solut report method suitabl high throughput screen reproduc result protocol describ applic wide varieti colloid particl develop around world group current expand scope quantifi encapsul molecul biomed interest protein nucleic acid | D004317;D005456 | T130;T195;T121;T109 |
34,665,962 | oil membran protect electrochem sensor foul ph insensit detect lipophil analyt take full advantag reagent label free sens capabl electrochem sensor frequent remain challeng interfer degrad sensor due uncontrol ph salin sampl solut foulant sampl solut present oil membran sensor protect techniqu allow permeat hydrophob lipophil analyt seal sensor compart contain ideal salin ph condit simultan block common hydrophil interfer protein acid base etc paper valid oil membran sensor protect techniqu demonstr continu cortisol detect via electrochem aptam base eab sensor encapsul eab cortisol sensor exhibit min concentr rise time maintain measur signal least h even extrem condit acid solut ph | D015374;D055664 | T059;T075 |
34,665,957 | effect exposur ambient air pollut pulmonari function impair korea korea nation health nutrit examin survey studi aim investig associ pulmonari function air pollut use data korea nation health nutrit examin survey nationwid cross section repres survey | D000393;D000397 | T131;T069;T080 |
34,665,956 | preval factor associ non use health servic peruvian popul covid symptomatolog secondari analysi nation household survey object studi estim preval non use health servic nuh associ factor peruvian symptom coronavirus diseas covid | D000086382 | T047;T067 |
34,665,955 | chronolog analysi acut hematolog outcom proton photon beam craniospin irradi pediatr brain tumor studi aim compar earli hematolog dynam acut toxic proton beam craniospin irradi prcsi photon beam craniospin irradi phcsi pediatr brain tumor | D000740;D001932;D061888 | T191;T047;T061 |
34,665,954 | associ bodi mass index surviv asian patient colorect cancer clinic signific bodi mass index bmi long term outcom extens investig asian patient colorect cancer crc studi aim describ associ bmi surviv plus provid bmi cut valu predict prognosi crc patient | D015179;D013851 | T033;T191 |
34,665,953 | crosstalk tumor associ macrophag neighbor cell hepatocellular carcinoma tumor microenviron general show substanti immunosuppress activ hepatocellular carcinoma hcc account suboptim efficaci immun base treatment difficult treat cancer crosstalk tumor cell various cell type tumor microenviron strong relat hcc progress treatment resist monocyt recruit hcc tumor microenviron various factor becom tumor associ macrophag tam distinct phenotyp tam often contribut weaken tumor specif immun respons aggress phenotyp malign recent singl cell rna sequenc data demonstr central role specif tam tumorigenesi treatment resist interact various cell popul hcc tumor microenviron review focus role tam crosstalk tam neighbor cell type hcc tumor microenviron | D006528;D008113 | T191 |
34,665,952 | treatment strategi prognost factor spinal cavern malform singl center retrospect cohort studi author aim identifi factor influenc neurolog function treatment order facilit clinician decis make treatment spinal cavern malform scm whether perform surgic intervent | D013345 | T047;T046 |
34,665,951 | effect angiotensin convert enzym gene insertiondelet polymorph genom instabl children live russian arctic main risk arteri hypertens manifest childhood children live far north especi suscept need inexpens non invas simpl diagnosi risk childhood patholog previous found genotyp dd indel polymorph marker ace gene found peopl risk develop cardiovascular patholog buccal micronucleus cytom assay genet analysi use work total schoolchildren citi apat age year old examin shown carrier allel tendenc increas frequenc cell micronuclei case homozyg ii variant frequenc occurr cell karyopycnosi signific higher carrier allel polymorph marker indel ace gene associ apoptot chang cell studi children indel polymorph marker ace gene use prognost marker process genom destabil earli stage develop human bodi | D007703;D011110 | T129;T116;T126;T045 |
34,665,950 | genom featur antibiot resist pseudomona aeruginosa strain isol patient cystic fibrosi russian feder cystic fibrosi cf common genet diseas manifest airway obstruct chronic respiratori infect preval infecti agent airway cf patient pseudomona aeruginosa studi aim determin sequenc type antimicrobi resist phenotyp gene defin adapt antibiot resist p aeruginosa isol recov cf patient russia total p aeruginosa strain cf patient analyz suscept antibiot determin disk diffus test whole genom sequenc wgs perform mgiseq platform spade softwar galaxi resfind pubmlst use analysi wgs data examin p aeruginosa isol belong differ sequenc type sts includ new sts high risk epidem clone st clonal cf p aeruginosa strain st st st detect non suscept ticarcillin clavulan cefepim imipenem observ isol respect tobramycin amikacin ciprofloxacin levofloxacin strain respect multidrug resist phenotyp detect isol examin strain gene beta lactamas vim st strain veb two st strain ges st strain per st strain found ciprofloxacin modifi enzym crpp gene detect isol aminoglycosid modifi enzym aad ant aac gene strain respect p aeruginosa isol cf patient russia demonstr high clonal divers similar p aeruginosa infect isol high risk clone clonal cf p aeruginosa strain detect | D003550;D011552 | T047 |
34,665,949 | peculiar ultrastructur mix biofilm caus agent diphtheria condit pathogen microorgan isol human respiratori tract post epidem period circul causat agent diphtheria popul maintain due carrier bacteria enter organ high level antitox immun pathogen enter intermicrobi interact repres opportunist microflora inhabit respiratori tract form biofilm | D003353;D004165 | T007;T047 |
34,665,948 | redict outcom pregnanc women reccur miscarriag determin relat content monocyt peripher blood produc il il il ifn identifi new criteria predict abort week gestat women threat earli termin recurr miscarriag materi method survey women gestat period week carri main group consist women recurr miscarriag threat earli termin time studi depend outcom pregnanc main group subdivid subgroup subgroup women whose pregnanc end time deliveri ii women preterm labor iii women termin pregnanc week miss pregnanc spontan miscarriag control group consist women uncompl pregnanc relat content il il il ifn monocyt determin flow cytometri facscanto ii becton dickinson usa women threaten earli miscarriag recurr miscarriag percentag il il cell popul peripher monocyt signific lower il cell higher compar control group p case statist signific differ found percentag ifn cell p retrospect analysi reveal group women termin pregnanc week signific decreas il monocyt peripher venous blood predict termin pregnanc week gestat possibl relat content il monocyt equal less sensit specif accuraci | D000026 | T047 |
34,665,947 | featur immunolog profil blood urin patient post infecti glomerulonephr time diagnosi treatment post infecti glomerulonephr pign current limit eras low symptom natur diseas lead search inform biolog marker diseas use immunolog indic blood urin studi carri order establish characterist chang immunolog paramet blood urin patient pign studi includ patient pign among patient hospit nephrolog depart republican clinic hospit health care ministri chuvash republ addit general accept research method patient underw determin indic innat acquir immun respons blood cd cd cd cdcd cdcd cd cd cdcd cdcd cell level igg iga igm circul immun complex c c urin level igg iga igm c c determin level cytokin il ra il il il il il il blood serum urin data obtain compar group healthi individu chang blood immunolog paramet identifi group patient pign indic activ innat immun increas number cdtlr cell humor compon adapt immun increas number b lymphocyt hyperimmunoglobulinemia increas igm iga level background decreas number cd lymphocyt regulatori cdcdhigh cell hypocomplementemia decreas level c c increas content c igg iga found urin cytokin profil blood patient pign character increas level pro anti inflammatori cytokin il ra il il il il il except il remain level healthi individu cytokin profil urin patient character increas level pro inflammatori cytokin il il il il anti inflammatori cytokin il chang content ra il il reveal featur immunolog profil blood urin patient pign reflect immunopathogenet mechan diseas | D001826;D005921 | T047;T031 |
34,665,946 | optim sperm process protocol subsequ molecular cytogenet studi one caus spontan pregnanc termin infertil birth children develop delay malform chromosom abnorm ca well spontan aneuploidi gamet phenotyp normal parent often coupl reproduct problem well spous one carrier ca turn program assist reproduct technolog art preimplant evalu zygot chromosom status part art program parent gamet examin assess level spontan aneuploidi rule access materi analysi ejacul fluoresc situ hybrid fish use examin male gamet obtain ejacul howev fish analysi number limit difficulti peculiar sperm head structur name supercondens state chromosom chromatin order optim fish protocol five differ protocol use pre hybrid process ejacul sampl obtain nine phenotyp normal men compar analysi hybrid effici show protocol use tris carboxyethyl phosphin hydrochlorid tcep decondens agent effect subsequ molecular cytogenet studi develop hybrid protocol combin proteolyt pretreat tcep thermal decondens use protocol pre hybrid treatment ejacul prepar effect | D007248 | T033;T047;T184 |
34,665,945 | diabet nephropathi possibl earli laboratori diagnost cours predict review literatur medic social signific diabet mellitus determin progress increas incid diseas well develop disabl reduc qualiti life macro microvascular complic patient work age particular develop diabet nephropathi dn develop one third patient type diabet dn third lead caus death diseas cardiovascular system oncolog patholog regard identif dn earli stage import task standpoint prevent favor prognosi cours diabet review present data possibl earli diagnosi dn use blood urin biomark well inform diagnost prognost valu analysi interpret indic microalbuminuria type diabet carri addit literatur data recent year inform valu determin marker podocyt damag role oxid stress product immun inflammatori factor vascular endotheli growth factor process onset develop dn present possibl practic use diagnosi dn clinic practic discuss literatur search review carri use databas rsci cyberleninka scopus web scienc medlin pubm period use follow keyword diabet mellitus diabet nephropathi marker diabet nephropathi kidney damag earli diagnosi diabet nephropathi | D003922;D003924;D003928 | T047 |
34,665,944 | potenti target preclin diagnost acut kidney injuri covid patient review literatur relev topic defin high occurr unfavor prognosi lack diagnost techniqu earli stage acut kidney injuri aki disclos patient covid coronavirus diseas screen medic literatur select aki preclin biomark consid main aim review public russian scienc citat index rsci scopus cochran librari medlin review risk factor hypoxemia increas intrathorac pressur associ acut respiratori distress syndrom ard hypertens ht involv endotheli dysfunct diabet mellitus consid associ aki explic cytopath immun mediat cytokin induc mechan covid associ aki pathogenesi multipl methodolog approach defin detect identif biomark base urin proteom metabolom screen perspect way preclin diagnost aki detect marker injuri hypoxia sensit proxim canaliculi atp metabolit reflect first stage energi metabol disord epithelium line canaliculi identifi studi instantan non invas investig differ marker regard possibl method prognost accuraci diagnosi initi stage aki substanti prevent start therapi make project diseas outcom improv due identif high sensit specif biomark | D058186;D000086382 | T047;T037;T067 |
34,665,943 | glutathion system activ blood overweight postmenopaus women one import compon antioxid defens system glutathion system activ overweight chang direct depend gender ethnic result studi involv overweight menopaus women mix studi involv postmenopaus women clinic anamnest examin divid group control bmi kg overweight group bmi kgm use hormon replac therapi use antioxid drug diseas endocrin genesi exacerb chronic diseas prematur earli menopaus surgic menopaus exclus criteria women studi lipid profil paramet calcul atherogen coeffici reduc oxid glutathion level calcul ratio glutathion transferas glutathion reductas activ determin blood overweight women show increas triacylglycerol p cholesterol low densiti lipoprotein level p assess glutathion system activ women main group compar control increas glutathion transferas p glutathion reductas p activ note howev reduc oxid glutathion level well ratio differ control valu result obtain indic activ glutathion system enzymat link respons chang lipid status postmenopaus women overweight | D005978;D017698 | T116;T034;T121;T123;T040 |
34,665,942 | efficaci safeti novel anti therapeut antibodi rc patient overexpress local advanc metastat gastric gastroesophag junction cancer singl arm phase ii studi current treatment option human epiderm growth factor receptor overexpress gastric cancer third line shown limit clinic benefit specif treatment immunohistochemistri ihc fluoresc situ hybrid negat patient report efficaci safeti novel anti antibodi rc patient overexpress advanc gastric gastroesophag junction cancer | D013274 | T191 |
34,665,940 | high effici deliveri crispr cas engin probiot enabl precis microbiom edit antibiot resist threaten abil treat infecti diseas spur interest altern antimicrobi technolog use bacteri conjug deliv crispr cas system program precis elimin antibiot resist bacteria repres promis approach requir high situ dna transfer rate optim transfer effici conjug plasmid tp use acceler laboratori evolut henc generat potent conjug deliveri vehicl crispr cas elimin target antibiot resist escherichia coli mous gut microbiota use singl dose appli system citrobact rodentium infect model achiev full clearanc within four consecut day treatment | D064307;D019936 | T032;T001;T007;T028 |
34,665,939 | crystal structur sar cov nucleocapsid protein c termin domain develop nucleocapsid target nanobodi ongo outbreak covid caus sar cov result serious public health threat global nucleocapsid protein major structur protein sar cov play import role viral rna pack replic assembl infect report two crystal structur nucleocapsid protein c termin domain ctd resolut respect two structur crystal differ condit contain ctds asymmetr unit respect interest despit differ crystal pack structur show similar dimer form smallest unit consist solut form measur size exclus chromatographi suggest import role ctd dimer nucleocapsid protein analyz surfac charg distribut identifi stretch posit charg residu lys arg involv rna bind screen singl domain antibodi sdab librari identifi four sdab target differ region nucleocapsid protein high affin futur potenti use viral detect therapeut purpos | D000086462;D061905 | T116;T129;T123 |
34,665,938 | effect probiot bifidobacterium bifidum g gastrointestin symptom patient type diabet mellitus treat metformin open label singl arm exploratori research trial metformin associ risk gastrointestin complic probiot bifidobacterium bifidum g bbg improv symptom diarrhea studi aim clarifi effect probiot bbg gastrointestin symptom type diabet mellitus patient use metformin | D000069985;D003924;D005767;D008687;D019936 | T007;T047;T121;T109 |
34,665,936 | dyslipidemia diabet kidney diseas classifi proteinuria renal dysfunct cross section studi region diabet cohort diabet kidney diseas dkd exacerb dyslipidemia increas incid atherosclerot cardiovascular diseas dkd concept includ typic diabet nephropathi atyp phenotyp without proteinuria investig dyslipidemia differ dkd phenotyp fulli studi | D002318;D003924;D003928;D050171 | T047;T046 |
34,665,935 | evalu diagnost valu next generat sequenc analysi residu liquid base cytolog specimen pancreat mass liquid base cytolog lbc wide use method process specimen obtain endoscop biopsi studi evalu next generat sequenc ngs analysi lbc specimen improv diagnost accuraci pancreat lesion | D021441;D010190 | T191 |
34,665,934 | egfr pivot player eer mediat function properti aggress stem tripl negat breast cancer cell tripl negat breast cancer tnbc defin aggress behavior limit respons chemotherapi lower overal surviv rate increas metastat potenti tnbc combin result extens extracellular matrix ecm remodel lead cytoskeleton rearrang activ epitheli mesenchym transit emt overexpress epiderm growth factor receptor egfr tnbc tumor link induc express emt relat molecul emt activ often associ increas metastasi stem recent describ crucial role egfrestrogen receptor beta er interplay regul invas cell matrix interact studi report egfr er function relationship connect aggress cancer stem cell csc like characterist tnbc cell er suppress mda mb cell subject downstream egfr inhibit andor estradiol stimul assess alter function paramet well morpholog characterist studi scan electron atom forc immunofluoresc microscopi moreov express local key emt csc relat marker also evalu real time qpcr immunofluoresc microscopi flow cytometri egfr inhibit result overal suppress aggress function characterist occur er mediat manner chang could attribut reduct molecular level emt stem link marker notabl reduc express notch signal constitu cell surfac proteoglycan syndecan collect studi highlight import egfr signal key effector aggress emt stem er depend way tnbc | D064726 | T191 |
34,665,931 | structur predict honey bee vitellogenin multi domain protein import insect immun vitellogenin vg implic central protein immun egg lay anim studi divers set speci suggest vg support health longev bind pathogen specif studi honey bee api mellifera indic vitellogenin vg gene undergo select driven local pathogen pressur determin complet structur full length vg flvg protein provid insight regard structur function relationship under allel variat honey bee vg describ term function two subdomain structur describ inform domain lack present structur predict restrain experiment data flvg honey bee achiev perform homolog model use alphafold use negat stain electron microscopi map restrict orient valid model approach identifi high conserv ca ion bind site von willebrand factor domain might central vg function thereaft use rigid bodi fit predict relat posit high resolut domain flvg model map repres first experiment valid full length protein model vg protein thus relev understand vg numer speci result also specif relev honey bee health topic global concern due rapid declin pollin number | D019476;D014819 | T116;T123 |
34,665,929 | passag cultur stimul condit influenc protein express primari fibroblast fibroblast fb key effector cell system sclerosi ssc fb stimul transform growth factor beta tgf consid posit control studi assess fibrogenesi lack standard tgf stimul might respons discrep experi perform differ condit use quantit proteom analysi evalu impact chang experiment condit proteom profil primari fb princip compon analysi pca identifi sever group differenti express protein influenc cell passag cultur medium concentr durat exposur tgf stimul bioinformat analysi reveal late passag express protein involv senesc tgf concentr time stimul correl express protein involv fibrogenesi inflammatori process data underlin need standard cultur condit allow inter data comparison futur vitro studi especi use omic approach | D040901;D012595 | T091;T047 |
34,665,928 | first trimest matern haemodynam adapt pregnanc placent embryon fetal develop prospect observ rotterdam periconcept cohort investig whether first trimest matern haemodynam adapt impact placent embryon fetal develop well birth outcom pregnanc without placenta relat complic | D010920;D010929 | T018;T042 |
34,665,927 | vaccin vaccin part human life view covid vaccin creat great breakthrough toward improv global health develop vaccin use made substanti decreas control infecti diseas abund emerg new vaccin facilit target popul allevi elimin contagi pathogen innat reservoir howev along infect like malaria hiv effect immun remain obscur impart great challeng scienc | D000086382;D014612 | T116;T047;T121;T129;T067 |
34,665,925 | distal nail embed treatment use autogen nail regrow nail tip nail avuls may excess curv invagin nail bed treat type ingrown toenail known distal nail embed case growth restor origin shape even nail bed howev often pain case may requir treatment report surgic approach appli six case distal nail embed involv pain deform nail caus nail tip invagin nail bed andor cessat forward nail growth method involv remov portion embed tip edg nail insert remov nail remain depress portion nail grow bulg six patient appli method pain nail deform resolv recurr use autogen nail reduc pressur imbal nail bed contribut improv morpholog nail nail bed addit risk hypertrophi nail reduc half nail adher nail bed special materi unnecessari method conduct simpl outpati depart procedur case fix nail section detach due bulg nail tip insert nail maintain case sever month nail grew bulg | D009263;D009264;D019651;D017695 | T184;T190;T037;T061;T033 |
34,665,922 | intrapartum antibiot childhood asthma allerg rhiniti retrospect cohort studi studi aim evalu associ intrapartum antibiot iabx asthma allerg rhiniti among children age year | D001249;D065631 | T047 |
34,665,921 | dna methyl tool explor age wild roe deer popul dna methyl base biomark age epigenet clock promis lead new insight evolutionari biolog age relat littl known natur environ affect epigenet age effect wild speci studi took advantag uniqu long term year longitudin monitor individu roe deer capreolus capreolus live two wild popul chiz troi fontain franc face differ ecolog context investig relationship chronolog age level dna methyl dnam generat novel dna methyl data n blood sampl extract leucocyt dna use custom methyl array horvathmammalmethylchip present three dna methyl base estim age dnam epigenet age train male femal sex combin investig sex differ influenc relationship dnam age chronolog age use sex specif epigenet clock result highlight old femal may display lower degre biolog age male identifi main site epigenet alter distinct age pattern two sex find open door promis avenu research crossroad evolutionari biolog biogerontolog | D019175;D003670 | T044;T015 |
34,665,920 | role perinat palliat care follow prenat diagnosi major incur fetal anomali multicentr prospect cohort studi describ prenat decis make process birth plan pregnanc amen plan perinat palliat care | D005315;D010166 | T047;T061 |
34,665,919 | transcrib ultraconserv region uc enhanc process edit mir cluster hypermethyl improv glioma prognosi transcrib ultraconserv region ucr noncod rnas deriv dna sequenc entir conserv across speci express alter mani tumor type although role ucr regul gene express propos function remain larg unknown herein describ epigenet silenc uc ucr glioma mechanist defin novel rna rna regulatori network uc modul biogenesi sever member mir cluster includ posit regul primari microrna pri mirna cleavag enhanc edit matur sequenc consequ express uc affect downstream mir regul gene includ transcript coregul ring yy bind protein rybp forkhead box p foxp final elucid clinic impact find show hypermethyl uc cpg island independ prognost factor associ better overal surviv lower grade glioma highlight import ucr cancer pathophysiolog | D019175;D005910;D035683 | T044;T191;T114;T123 |
34,665,916 | effect topic applic differ molecular weight marin fish skin collagen oligopeptid uvb induc photoag rat skin object work develop peptid product process exact molecular weight propiti topic applic cosmet investig effect enzymolysi deriv peptid uvb induc photoag rat skin | D015595 | T033;T042 |
34,665,915 | genom wide associ studi reveal cupin domain protein oscdp regul seed vigour rice seed vigour imper trait direct seed rice studi examin genet regul seedl percentag earli germin use genom wide associ studi rice one major quantit trait loci qsp seedl percentag identifi candid gene valid qsp encod cupin domain protein oscdp synthesi kda globulin disrupt gene oscdp mutant reduc seed vigour includ germin potenti seedl percentag earli germin rice lack accumul kda globulin observ matur grain oscdp mutant signific lower amino acid content observ matur grain earli germin seed oscdp mutant compar wild type rice oscdp regul seed vigour main via modul amino acid eg met glu tyr contribut hydrogen peroxid h accumul germin seed result provid import insight applic seed prime amino acid select oscdp improv seed vigour rice | D012275 | T002;T168 |
34,665,911 | ephemer forest regener limit carbon sequestr potenti brazilian atlant forest although deforest remain widespread tropic mani place experienc signific forest recoveri ie forest transit offer optimist outlook natur ecosystem recoveri carbon sequestr natur regener forest howev may persist nuanc understand driver forest chang tropic critic ensur success reforest effort carbon sequestr target use year detail land cover data investig forest trajectori municip brazilian atlant forest af biodivers conserv hotspot although deforest evid region deforest revers typic forest transit trajectori preval trend af account municip howev simultan reforest revers region municip suggest short term increas nativ forest cover necessarili translat persist trend absenc revers reforest forest region could sequest pg c three time actual estim carbon sequestr pg c also show failur distinguish nativ plant forest would mask nativ forest cover loss region overestim reforest mha carbon sequestr natur forest regener pg c deforest revers preval urban municip limit forest cover high agricultur product highlight import favor socioeconom condit promot reforest success forest restor effort requir develop enforc environment polici promot forest regener ensur perman regrow forest crucial fate conserv af also tropic nation achiev restor carbon sequestr commit | D057965;D017753 | T070;T062;T082;T067 |
34,665,908 | total synthes conjug readi repeat unit acinetobact baumannii ab glycoconjug vaccin develop acinetobact baumannii opportunist pathogen caus serious nosocomi infect one multidrug resist strain ab result bacteremia pneumonia wound infect associ high morbid mortal structur uniqu glycan surfac bacteria attract target develop glycoconjug vaccin report first total synthesi dens function trisaccharid repeat unit baumannii ab well two analogu construct cis linkag rare sugar reli doubl serial invers strategi judici select build block reaction condit allow stereoselect glycosyl instal acetamido group hydroxybutanoyl chain | D040981;D003428 | T007;T047 |
34,665,907 | graph theori base whole brain approach assess mood state differ adolesc young adult bipolar disord identifi hub brain dysfunct adolesc young adult bipolar disord bd aya could provid target earli detect prevent treatment previous neuroimag studi across mood state bd aya scarc often examin limit brain region potenti prohibit detect import region use data driven whole brain intrins connect distribut icd approach investig dysconnect hub across mood state bd aya | D001714 | T048 |
34,665,906 | role nitric oxid regul epiderm permeabl barrier function nitric oxid free radic molecul synthes nitric oxid synthas nos regul multipl cellular function varieti cell type nos includ endotheli nos eno induc nos ino neural nos nnos express keratinocyt express level ino nnos decreas age insuffici link develop number disord diabet hypertens sever atherosclerosi convers excess level induc cellular oxid stress physiolog level requir maintain normal function cell includ keratinocyt also regul cutan function includ epiderm permeabl barrier homeostasi wound heal stimul keratinocyt prolifer differenti lipid metabol topic applic divers group agent generat nitric oxid call donor nitroso n acetyl l penicillamin snap delay permeabl barrier recoveri barrier disrupt skin ino still requir epiderm permeabl barrier homeostasi review summar regulatori role play epiderm permeabl barrier function under mechan involv | D004817;D009569 | T024;T121;T197 |
34,665,905 | gout associ uric acid crystal induc tophi ulcer impair wound heal novel gouti ulcer model studi aim establish novel gouti ulcer rat model induc monosodium urat msu deposit preliminarili explor msu crystal affect wound heal msu crystal subcutan inject back rat simul tophi format ulcer ultrasound use detect format gouti tophi msu crystal deposit histopatholog chang analys haematoxylin eosin stain skin tophi becam broken model group full thick tissu defect area made back phosphat buffer salin pbs control day wound infiltr neutrophil macrophag express inflammatori marker includ interleukin il tumour necrosi factor tnf nod like receptor protein nlrp examin immunohistochem stain western blot respect first subcutan inject rat local tissu show red swell indic inflamm approxim day tophi like manifest appear approxim day tophi appear heterogen hyperecho ultrasound swell red injur tissu area increas approxim day skin tissu necrosi seen small area approxim day skin necrosi enlarg tophi ulcer approxim day accompani yellowish white chalki secret haematoxylin eosin stain show dermal deposit needl like crystal surround granulomat inflamm day wound immunohistochem stain show infiltr neutrophil macrophag express inflamm relat protein il tnf nlrp upregul gouti ulcer compar pbs control gouti ulcer complet heal day compar pbs control studi novel gouti ulcer rat model construct also reveal exist persist chronic inflamm | D015210;D006073 | T047 |
34,665,904 | improv outcom patient diabet foot ulcer despit differ baselin characterist incid diabet increas worldwid concomit rais number patient diabet foot diseas diabet foot diseas treatment receiv attent past decad culmin creation multidisciplinari outpati clinic time complex patient seem increas aim articl studi differ patient characterist outcom ulcer heal ulcer free surviv day patient diabet foot ulcer two prospect cohort year prospect cohort studi patient one diabet foot centr expertis clinic outcom determin follow period month outcom differ baselin characterist comorbid differ ulcer relat outcom cohort includ consecut diabet foot ulcer patient centr period n n age vs p preval end stage renal diseas vs p signific higher recent popul recent popul higher heal rate vs p higher median ulcer free surviv day ulcer heal day iqr vs iqr p fewer minor amput vs p peopl diabet foot ulcer treat older frequent diagnos esrd compar popul characterist similar ulcer relat outcom better | D003920;D017719 | T047 |
34,665,903 | depress anxieti screen emerg depart patient recurr abdomin pain evid synthesi clinic practic guidelin recurr abdomin pain emerg depart ed might repres opportun screen depress andor anxieti | D059350;D003863 | T048;T047;T184 |
34,665,902 | thymol amelior fluorouracil induc intestin mucos evid regulatori effect tgf mapk pathway nf b fluorouracil fu front line cytotox therapi howev intestin mucos well known advers event fu limit therapeut use inde thymol monoterpen compon essenti oil deriv thymus potenti anti inflammatori immunomodulatori activ therefor studi aim investig potenti chemoprotect effect thymol fu induc intestin mucos rat either expos two dose fu mgkg ip andor treat thymol mgkg oxid stress inflammatori marker well patholog chang assess fu induc sever intestin damag evidenc histopatholog chang well oxid inflammatori respons thymol pretreat inhibit fu induc oxid stress reduc lipid peroxid increas intestin level antioxid system moreov inflammatori respons marker interleukin prostaglandin e cox also improv immunoblot analysi also show thymol signific inhibit fu induc express nuclear factor b tumor necrosi factor transform growth factor tgf addit suppress p phosphoryl c jun n termin kinas p jnk mitogen activ protein kinas protein express studi first demonstr promis protect effect thymol fu induc intestin mucos inhibit oxid inflammatori pathway suppress tgf pp jnk signal | D007410;D052016 | T047;T046 |
34,665,900 | clinic outcom ceram singl crown fix dental prosthes support ceram implant systemat review meta analys analyz clinic outcom ceram singl crown scs fix dental prosthes fdps support ceram implant | D015921;D019232 | T047;T074;T067 |
34,665,899 | transplant high fat fed mous microbiota zebrafish larva identifi myd depend acceler hyperlipidaemia gram posit cell wall compon gut dysbiosi import modifi patholog includ cardiovascular diseas understand role individu microb limit use transplant mous microbiota microbiota defici zebrafish larva studi interact member mammalian high fat diet associ gut microbiota lipid rich diet challeng tractabl model speci find zebrafish larva suscept hyperlipidaemia expos mous high fat diet associ microbiota effect driven two individu bacteri speci fraction mous high fat diet associ microbiota find stenotrophomona maltophilia increas hyperlipidaem potenti chicken egg yolk zebrafish larva independ direct interact maltophilia zebrafish host colon live exposur heat kill enterococcus faecali acceler hyperlipidaemia via host myd signal hyperlipidaem effect replic exposur gram posit toll like receptor agonist peptidoglycan lipoteicho acid myd depend manner work demonstr applic zebrafish tractabl host identif gut microb induc condit host phenotyp via microbiota transplant subsequ challeng high fat diet | D006949;D064307 | T047;T001;T032;T028;T033 |
34,665,898 | eifa knockout mice reveal decreas life span metabol syndrom eukaryot initi factor eifa kda protein function minor initi pathway affect translat subset messeng ribonucl acid mrnas intern ribosom entri site ire contain mrnas andor mrnas harbor upstream near cognatenon aug start codon non canon initi event import regul protein synthesi cellular develop andor integr stress respons select eifa knockdown cellular system signific inhibit translat mrnas reli altern initi mechan translat howev exist gap understand eifa function mammalian system vivo organism level ex vivo cell use eifa knockout ko mous model present evid implic eifa biolog age metabol syndrom central toler discov eifa ko mice reduc life span eifa play import role mainten lipid homeostasi control glucos toler insulin resist also reduc abund b lymphocyt dendrit cell thymic medulla mice also show eifa ko affect male femal mice differ suggest eifa may affect sex specif pathway interest experi involv pharmacolog induct endoplasm reticulum er stress tunicamycin reveal substanti differ respons er stress eifa ko wild type mice identif eifa function develop metabol syndrom bear promis identif specif eifa target respons chang | D050356;D008136 | T044;T079;T102 |
34,665,897 | assess genet counselor communic respons virtual asynchron simul video prompt onlin method teach assess communic skill meet need remot educ covid pandem also futur demand flexibl train method studi aim explor util standard video prompt intend elicit sampl genet counselor gcs interperson psychosoci counsel skill describ variat gcs socioemot communic respons seri videotap communic challeng analyz previous record communic gcs respond set videotap simul client prompt relat cancer prenat counsel session appli roter interact analysi system prompt gcs respons focus proport socioemot content indic interperson psychosoci counsel skill use analyz respons gcs cancer prompt gcs prenat prompt two sampl test explor differ proport socioemot content gcs respons prompt within across two scenario overal socioemot statement account sd gc statement respons prenat prompt sd statement respons cancer prompt bonferroni adjust p proport socioemot communic individu prompt respons vari sd sd across cancer prompt seri sd sd across prenat prompt seri across two scenario two match prompt show signific differ proport gcs socioemot content prompt respons ps differ appear relat differ socioemot natur prompt find inform onlin method communic assess use restrict person learn due covid well futur hybrid train research effort | D000086382;D000072117 | T097;T047;T067 |
34,665,896 | research particip share genom screen result famili member public health impact genom screen enhanc cascad test howev cascad test depend communic result famili member barrier facilit famili communic research follow clinic genet test factor impact dissemin genom screen result unknown use pragmat electron medic record genom network emerg studi explor report share practic particip underw genom screen across unit state six emerg site return genom screen result most domin medic action disord survey adult particip regard communic result first degre relat across site particip complet month andor month post result survey month respond share result first degre relat share third first degre relat notifi result half particip receiv result genet provid share first degre relat compar particip receiv result non genet provid frequent reason share feel oblig inform could help famili member make medic decis common reason indic share famili member young contact close data indic profession return result may impact share pattern suggest need continu educ healthcar provid regard approach facilit share genet result within famili final data suggest intervent increas share may univers effect regardless origin genet result | D005190;D023281 | T079;T099;T091;T054;T062 |
34,665,895 | trimetazedin hyperinsulinimea euoglycemia n acetyl cystein vitamin c new approach concept manag aluminum phosphid poison aluminum phosphid alp common use power suicid tool exact mechan acut toxic well defin despit high mortal rate well support treatment includ rapid decontamin institut resuscit measur current studi aim investig new combin therapi use trimetazidin n acetyl cystein vitamin c hyperinsulinemia euglycemia manag acut alp poison acut alp induc cardiotox hemodynam chang hepatotox evalu use electrocardiogram creatinin kinas mb iso enzym troponin blood pressur random blood glucos level liver function test histopatholog chang heart liver rabbit model alp poison result show new regimen therapi amelior toxic effect alp signific improv surviv cardiovascular hemodynam paramet addit histopatholog chang result highlight strong cardioprotect antioxid hepatoprotect effect new combin therapi along correct hemodynam chang hyperglycemia potenti target manag acut alp poison | D006946 | T047 |
34,665,894 | adhes heterogen differ compart oral mucos rete ridg rete ridg play critic role maintain epiderm structur mechan properti notabl rete ridg divid three compart base slope tip present studi aim explor whether three compart distinct adhes function collect normal masticatori mucosa prepar paraffin embed section immunohistochemistri immunofluoresc stain use analys express pattern integrin differ compart rete ridg observ whether differ compart distinct adhes forc dermal epiderm junction separ experi perform peel oral epithelium lamina propria treatment cold salin h result show integrin prefer basal layer keratinocyt close adjac base compart rete ridg oral mucos epithelium separ under lamina propria tip rete ridg peel cold salin treatment conclus adhes forc basal layer keratinocyt base rete ridg stronger tip | D000269;D012867 | T167;T022;T073 |
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