PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,663,186 | real time monitor pseudomona aeruginosa biofilm growth dynam persist cell erad biofilm format appear persist cell low metabol rate key factor affect convent treatment failur antibiot resist use imped base measur crystal violet stain tradit cultur studi biofilm growth dynam pseudomona aeruginosa strain effect seven convent antibiot real time growth quantif reveal exposur establish p aeruginosa biofilm certain concentr ciprofloxacin ceftazidim tobramycin induc emerg persist cell show differ morpholog pigment well increas antibiot resist whole genom sequenc wildtyp persist cell identifi sever snps genom invers genom duplic one strain howev mutat uniqu associ persist suggest persist phenotyp may relat metabol transcript chang given mannitol propos activ bacteri metabol synergist combin mannitol ciprofloxacin evalu clinic h p aeruginosa biofilm administ dose mgl mannitol capabl prevent persist cell format effici activ dormant bacteria make suscept antibiot result confirm use viabl coloni count test ciprofloxacin mannitol combin appear fulli erad matur biofilm conclud imped base biofilm diagnost permit antibiot suscept test identif persist cell great potenti clinic practic could aid establish treatment breakpoint emerg biofilm relat infect | D018441 | T007 |
34,663,184 | emot process therapi complic grief prior research main conduct depress observ client improv capabl process emot predict better therapeut outcom current compar studi aim investig whether emot process relat therapeut chang complic grief | D004644;D006117 | T041 |
34,663,183 | virtual groceri store foster healthi nutrit among senior atlanticar health system provid health care servic resid atlant citi urban food desert southern new jersey purpos studi explor baselin data first four month program better understand particip purchas behavior improv health atlant citi senior altanticar establish virtual groceri store program vgsp program cover fee associ onlin groceri shop resid jeffri tower low incom hous complex cours month particip place total order rang order order yield item top three type food purchas fruit veget dairi egg meat fish one third item prepar two third perish almost half item nutrit valu half major high nutrit less third particip use nj snap fund purchas groceri onlin futur effort need uncov explan purchas along identifi potenti strategi increas consumpt healthier food option | D000072001;D063105 | T057;T064;T055;T061;T033 |
34,663,182 | complet genom sequenc assess mutat associ protein dynam first indian bovin ephemer fever virus befv isol bovin ephemer fever bef emerg diseas caus bovin ephemer fever virus befv although pose huge econom threat livestock sector complet viral genom inform south asian countri includ india lack | D002418;D004810;D018115 | T047;T005 |
34,663,180 | two piwi ago like function silenc somat gene chromatin level srna biogenesi mechan involv either rnase iii cleavag ping pong amplif differ piwi protein harbour slicer activ follow question mechan transgen induc silenc ciliat paramecium need dicer activ two ptiwi protein pathway involv primari sirna produc non translat transgen secondari sirna target endogen loci data indic signatur ping pong amplif dicer cleavag long dsrna ptiwi prefer differ sub cellular local differ prefer primari secondari sirna load mutual exclus piwi enrich antisens rnas show general prefer uridin rich srnas along entir srna length addit ptiwi load sirna show u signatur data indic ptiwi methyl contribut strand select dicer cleav sirna unexpect function two distinct veget piwi extend increas knowledg divers piwi function divers silenc pathway describ unusu mode action piwi protein extend great varieti piwi associ rnai pathway moreov rais question whether could primordi one | D020868 | T045 |
34,663,179 | rrdd rna global structur base rna three dimension structur classif databas three dimension structur rna usual play import role recognit rna bind protein along discov rnas sever rna databas develop studi function rna base sequenc secondari structur local structur motif global structur base rna function structur differ rnas classifi store scor dart respect classif rna structur use rna structur predict function annot howev scor dart updat studi present rna classif databas rrdd base rna fold global structur similar rrdd includ rna chain pdb mmcif format structur classifi rna fold rna chain pdb mmcif format structur align cluster rna fold respect analys rna structur rrdd find cluster member cluster includ rrnas riboswitch trnas map rrdd rfam found rnas without annot rfam annot structur align exampl analys trnas found trna success group rrdd rfam classifi one famili final provid web interfac rrdd offer function brows rrdd annot rna structur find templat rna homolog model | D030561;D008958;D009690;D012984 | T082;T073;T170;T028;T090 |
34,663,177 | isofluran allevi hypoxiareoxygen induc myocardi injuri reduc mir mediat sirt object studi investig role mir target gene iso protect hypoxiareoxygen hr induc myocardi injuri | D007530;D035683;D037761 | T116;T121;T109;T123;T114;T126 |
34,663,176 | clinic util procalcitonin associ pathogen microorgan review summar relationship pct pathogen evalu clinic util pct diagnosi clinic diseas condit monitor evalu guid medic decis make explor current knowledg mechan pathogen caus chang pct level lipopolysaccharid microorgan stimul cytokin product host cell turn stimul product serum pct pathogen differ virul mechan lead variabl host inflammatori respons differ specif signal transduct pathway result variabl serum pct concentr mechan signal transduct fulli elucid studi necessari ascertain pct fluctuat rang pathogen pct level help distinguish certain pathogen decid antibiot indic monitor respons antibiot | D000900;D000077740 | T195;T121;T116;T123 |
34,663,175 | revisit approach consider urinalysi urin cultur reflex test urinalysi consid world oldest laboratori test today mani laboratori use macroscop urinalysi screen tool determin subject urin sampl microscop urinalysi andor bacteri cultur reflex urin microscopi practic decad reflex urin cultur recent evid base guidelin regard optim reflex criteria workflow lack standard approach hinder part lack harmon urinalysi urin cultur practic heterogen patient popul studi lack provid adher recommend practic review summar studi evalu perform reflex urin microscopi reflex urin cultur particular context urinari tract infect also examin report clinic outcom reflex urinalysi intervent impact antibiot stewardship effort final discuss laboratori oper consider implement reflex algorithm | D016482;D014552 | T047;T059 |
34,663,174 | integr network pharmacolog vitro model investig hippocamp neurotox induc atrazin atrazin atr common appli herbicid agricultur found caus hippocamp injuri rodent howev under toxicolog target mechan unclear studi network pharmacolog analysi vitro model integr investig effect mechan atr induc hippocamp neurotox total target hippocamp neurotox induc atr predict gene ontolog go kyoto encyclopedia gene genom enrich kegg enrich analysi suggest target relat multipl go term signal pathway investig under mechan top hub target screen includ tumor protein p tp caspas casp prostaglandin endoperoxid synthas ptgs camp respons element bind protein creb estrogen receptor esr jun proto oncogen jun brain deriv neurotroph factor bdnf catalas cat sirtuin sirt fos proto oncogen fos moreov cell count kit cck lactat dehydrogenas ldh assay show atr time dose depend cytotox h cell tunel stain reveal atr increas apoptot ratio addit real time quantit polymeras chain reaction rt qpcr result indic mrna express level hub target show signific chang except esr jun studi demonstr atr main act multipl target signal pathway exert hippocamp neurotox result provid initi evid explor toxicolog mechan atr | D001280;D004365;D020258 | T121;T109;T123;T131;T037 |
34,663,171 | associ asthma status prenat antibiot prescript fill among women medicaid popul pregnant women asthma increas frequenc respiratori viral infect exacerb risk women asthma may subject increas surveil pregnanc may therefor increas risk antibiot receipt object studi assess relationship matern asthma outpati prenat antibiot prescript fill inform antibiot stewardship | D001249 | T047 |
34,663,170 | neuroprotect effect bryophyllum pinnatum flavonoid aluminum chlorid induc neurotox rat toxic metal aluminum accumul brain associ pathophysiolog sever neurodegen disord bryophyllum pinnatum leav contain vast array polyphenol particular flavonoid may play role prevent toxic degen effect brain studi assess neuro restor potenti leav b pinnatum enrich flavonoid fraction bpfrf aluminum induc neurotox rat neurotox induc male wistar rat oral administr mgkg bodi weight aluminum chlorid alcl day rat group five n control untreat rivastigmin group alcl group bpfrf group mgkg bwt day neuron chang hippocampus cortex biochem histolog evalu express pattern acetylcholinesteras ach mrna assess use semi quantit revers transcript polymeras chain reaction protocol molecular interact bpfrf compound investig silico result reveal oral administr bpfrf amelior oxid imbal augment antioxid system decreas lipid peroxid caus alcl bpfrf administr also contribut regul ach mrna transcript improv histolog featur hippocampus cortex molecular dock studi reveal strong molecular interact bpfrf compound catalas superoxid dismutas glutathion peroxidas overal find suggest neuroprotect effect bryophyllum pinnatum aluminum induc neurotox | D031962;D018696 | T169;T121;T002 |
34,663,166 | prospect examin self harm three year contact child protect servic cps examin preval correl self harm among adolesc three year follow investig us child protect servic cps alleg child maltreat particip n male white drawn nation survey child adolesc well cohort ii self harm assess conclus cps investig month follow descript statist multivari logist regress use assess differ self harm time demograph characterist maltreat type home placement preval self harm among older adolesc year remain stabl among younger adolesc year declin approxim youth report self harm multipl survey wave nativ american asianpacif island youth five time like report repeat self harm research warrant understand heighten risk | D002649;D016728 | T048;T055 |
34,663,162 | impact genet test smoke distribut risk factor patient recurr acut chronic pancreat aim present studi assess impact smoke dose durat distribut risk factor patient rap cp impact genet test distribut risk factor patient idiopath rap cp | D050500 | T047 |
34,663,161 | therapeut effect statin airway remodel asthma asthma chronic inflammatori diseas airway usual character remodel hyperrespons episod obstruct airway under chronic airway inflamm lead patholog restructur larg small airway sinc effect current asthma medic airway remodel met contradict mani therapeut agent redirect primari use treatment asthma treatment could target sever signal molecul implic inflammatori airway remodel process asthma would ideal choic | D001249;D019161 | T047;T121;T109 |
34,663,160 | intradisc vacuum phenomenon spinal degener cross section analysi subject intradisc vacuum phenomenon ivp collect gas within intervertebr disc report various spinal disord exact role ivp spinal degener lead low back pain lbp unclear aim obtain preval ivp patient lbp second aim understand whether ivp associ intervertebr disc degener ivdd modic chang subchondr sclerosi ss | D007403;D055959;D017116 | T190;T047;T023;T184 |
34,663,159 | integr transcriptom proteom approach snake venom profil snake venom contain mani protein peptid isoform high level sequenc variat even within singl speci | D017812;D059467 | T086;T014;T081 |
34,663,154 | treatment outcom gastrointestin bleed due peptic ulcer eros blue studi peptic ulcer eros common caus upper gastrointestin bleed aim studi investig manag outcom patient | D016558;D010437 | T047;T061 |
34,663,152 | resili adolesc though weaken pandem relat lockdown serv protect depress sleep problem adolesc face advers suscept depress sleep problem resili import protect mechan cope advers covid pandem adolesc face hardship includ pull school unabl social friend mandat lockdown three aim studi first sought test whether chines adolesc resili strengthen maintain weaken covid lockdown second sought test whether adolesc resili predict depress symptom turn sleep problem third sought examin role social support may play partial longitudin survey studi demonstr via within subject test bayesian equival chines adolesc resili weaken lockdown compar pandem howev resili remain import predictor mediat model demonstr higher resili associ fewer depress symptom turn predict fewer sleep problem moreov found social support moder mediat strong social support reduc negat effect low resili level result help shed light fragil resili import adolesc mental health face advers might support adolesc experienc social distanc mandat otherwis isol peer | D000086382;D012893 | T048;T047;T067 |
34,663,150 | simul self report drive among young adult without prenat cocain exposur object exploratori studi aim examin associ execut function simul self report drive behavior among young adult without histori prenat cocain exposur pce method young adult driver pce n drug exposur nde n recruit ongo longitudin birth cohort studi assess effect pce develop mean age male valid us driver licens report independ drive without licens particip complet execut function task ie stop signal task groton maze learn task self report drive measur ie checkpoint riski drive scale c rds outsid cab averag stop signal reaction time measur inhibitori control number exploratori error measur visuo spatial work memori total c rds score measur self report riski drive particip complet high fidel drive simul scenario minisim cab nation advanc drive simul nad yield indic drive perform shown previous research correl inhibitori control eg averag speed standard deviat lane posit sdlp work memori minimum headway time lane departur multivari linear regress model test whether pce status licensur status execut function measur associ simul drive measur c rds control sex result multivari regress model demonstr inhibitori control work memori pce group status signific associ drive outcom licensur signific associ total lane departur se p c rds se p conclus exploratori studi suggest young adult pce similar neurocognit perform drive behavior non drug expos nde peer find add grow literatur demonstr effect pce cognit function childhood may persist young adulthood research similar group young driver naturalist drive context ie instrument vehicl need definit translat confirm find | D001334;D003042 | T131;T121;T056;T109 |
34,663,149 | colon target dosag form capecitabin use folic acid anchor modifi carbon nanotub vitro cytotox apoptosi vivo roentgenograph studi develop dosag form compris capecitabin load carbon nanotub target deliveri colon | D037742 | T104;T073 |
34,663,148 | use stabil studi guidelin challeng pharmaceut product deliv multidos contain requir use stabil studi moreov pharmaceut product requir dilut reconstitut prior use also requir use stabil studi use stabil describ well pharmaceut product remain stabl use within particular closur system use period pharmaceut product remain within physic chemic microbiolog specif retain safeti efficaci perform even though differ guidelin avail specif inform use stabil studi smooth guid applic regulatori submiss par use stabil studi perform accord various guidelin publish regulatori agenc appropri justifi way satisfi regul review explor current use stabil guidelin numer exampl perform use stabil studi challeng use stabil relev aspect | D004349 | T074;T073 |
34,663,147 | food access food consumpt children nutrit status smallhold farmer sinabung erupt prone area indonesia destruct impact result volcan erupt affect food product sever lead deterior food access food consumpt thus spot urgenc research food access household food consumpt nutrit status children sinabung erupt prone area indonesia cross section studi carri among farmer farmer plus farm labor household head farmer interview administ questionnair use data collect three indic use assess nutrit status children name weight age waz height age haz weight height whz data household food consumpt collect use food consumpt score fcs household food consumpt among two group farmer signific differ farmer plus farm labor slight better varieti food sinc could collect free veget fruit field work farm labor household food consumpt signific associ nutrit status children group farmer correl household food consumpt underweight signific associ improv food access food consumpt policymak provid inform job opportun agricultur labor anoth farm farmer help reach job especi unpredict circumst like sinabung erupt | D000067565;D009752 | T097;T033 |
34,663,146 | drive pandem studi speed phone use drive covid restrict respons covid pandem restrict implement howev data indic road crash rate decreas proportion declin traffic densiti studi explor speed phone use drive road behavior associ high crash risk chang result covid restrict queensland | D001334;D000086382;D040421;D000075782 | T047;T073;T056;T054;T067 |
34,663,145 | stereolithographi print technolog pharmaceut review three dimension print dp technolog innov tool use manufactur medic devic produc alloy replac biolog tissu produc custom dosag form stereolithographi sla print techniqu rapid high accur produc finish product uniform qualiti formul optim perfect tool artifici intellig learn techniqu complex designsshap fabric sla use photopolymer principl differ dp technolog introduc promis sla commerci applic focus high speed effect sla highlight work principl sla materi use applic techniqu wide rang differ sector highlight review innov idea print custom pharmaceut dosag form also present sla compromis sever advantag method cost effect control integr materi greater speed develop sla allow develop print pharmaceut devic consid present trend expect sla use along convent method manufactur model print technolog may util novel tool deliv drug demand review use research work print technolog | D001185;D000076227 | T074;T066;T073;T090 |
34,663,143 | myriad face activ tuberculosi intrapulmonari bronchial arteri pseudoaneurysm bronchial arteri ba pseudoaneurysm uncommon vascular complic tuberculosi tb earli diagnosi crucial due risk ruptur life threaten hemorrhag immedi intervent warrant massiv hemoptysi due high mortal various caus massiv hemoptysi tb bronchiectasi aspergilloma lung abscess lung cancer necrot pneumonia cystic fibrosi activ pulmonari tb well chronic pulmonari tb manifest massiv hemoptysi hemoptysi activ tb occur due ulcer bronchiolar wall erod wall adjac ba pulmonari arteri chronic tb due hypertrophi bronchial arteri bronchiectasi aspergilloma herein report case pulmonari tb caus intrapulmonari ba pseudoaneurysm young male patient present acut massiv hemoptysi ba pseudoaneurysm well hypertrophi bronchial arteri embol use polyvinyl alcohol pva particl | D017541;D004621;D014376 | T047;T046;T061 |
34,663,142 | limit endoscop mucos inflamm equival mayo endoscop subscor unaffect clinic relaps ulcer coliti mayo endoscop subscor simpl valid endoscop score ulcer coliti rang inflamm consid score report analyz rang inflamm clinic relaps use mayo endoscop subscor mes aim studi investig relaps potenti limit mucos inflamm endoscop remiss equival mes | D003093 | T047 |
34,663,141 | relationship bodi mass index belt placement abdominopelv injuri motor vehicl crash crash injuri research engin network ciren studi obes import implic motor vehicl safeti due alter crash injuri respons increas mass improp seatbelt placement abdomin seatbelt sign asb anterior superior iliac spine asi motor vehicl crash mvcs often correl abdominopelv trauma investig relationship bodi mass index bmi lap belt placement incid abdominopelv injuri use comput tomographi ct evalu subcutan asb mark locat relat asi | D000063;D012622 | T073;T037;T067 |
34,663,140 | mitochondri dna control region sequenc chines sui popul southwestern china sui peopl offici recognis peopl live southwest china lack genet research especi base mitochondri dna data | D044466;D004272 | T114;T098;T123 |
34,663,137 | develop neonat high risk preterm infant comparison full term counterpart studi preterm infant usual exclud high risk neonat infant neurolog problem howev import studi high risk preterm infant better understand later development problem therefor cross section studi aim compar cognit motor languag social emot develop high risk preterm pt infant infant born full term ft biolog vulner earli develop first month age sampl compris infant born pt born ft assess independ subsampl month age consid correct age prematur pt infant infant develop cognit motor languag social emot evalu use bayley iii scale medic chart review obtain clinic histori multivari analysi varianc analysi varianc test perform examin differ group relat infant development indic control age socioeconom variabl although pt infant perform signific poor ft counterpart score pt group still within normal rang bayley iii domain cognit languag motor social emot ft counterpart find present studi provid better understand development prognosi high risk pt infant extend support prevent intervent program improv earli childhood develop | D002657;D007234 | T040;T033;T039;T100 |
34,663,136 | depth analysi crash contribut factor potenti ada intervent among risk driver use shrp naturalist drive studi motor vehicl crash remain signific problem advanc driver assist system ada potenti reduc crash incid sever optim requir comprehens understand driver specif error environment hazard real world crash scenario therefor object studi quantifi contribut factor use strateg highway research program shrp naturalist drive studi nds identifi potenti ada intervent make suggest optim ada real world crash scenario | D000063;D001334 | T056;T037;T067 |
34,663,134 | explor risk sexual recidiv treatment respons len earli trauma advers childhood experi ace common histori individu sexual offend mani risk factor sexual recidiv resembl symptom earli trauma earli trauma may present respons barrier engag offens focus treatment use ace scale current studi aim examin relationship ace score static dynam risk assess score ii examin whether ace score differ treatment complet versus noncomplet final iii examin whether ace score predict treatment noncomplet ace score retrospect code file adult men receiv communiti base assess andor treatment new zealand sexual offens children n n individu analys although effect size general small static risk general self regul dynam risk factor correl posit ace score ace score higher treatment noncomplet versus complet higher dynam risk assess score ace score increas odd treatment noncomplet implic futur research enhanc treatment respons discuss | D057237;D000075665;D012742 | T037;T048;T098 |
34,663,133 | rememb togeth social interact facilit retriev reduc individu featur within bound represent encount social scene appear rapid automat detect social interact represent interact peopl appear bound togeth via mechan joint attent result enhanc memori even particip unawar memori requir howev even though access facilit social bound represent predict individu featur represent less effici encod featur therefor migrat constitu interact individu confirm experi overal memori interact compar non interact dyad facilit bind featur within individu weak result featur migrat error experi demonstr role conscious strateg process particip awar memori would test awar attent focus individu object allow bind featur result support account two form process initi automat social bind process interact individu repres one episod memori facilit access stage attent focus individu enabl bind featur within individu object | D007207;D008570 | T041 |
34,663,132 | ca nt see case relaps polychondr relaps polychondr rp rare treat potenti lethal autoimmun disord involv central nervous system cns rp rare present make extrem difficult diagnos report present case year old hispan woman present sudden onset headach blur vision magnet reson imag mri brain orbit show leptomening enhanc addit asymmetr thicken enhanc globe lumbar punctur consist asept mening pictur place empir treatment presumpt cns tuberculosi vision deterior diagnos rp cns ocular involv place high dose steroid dramat rapid respons immunosuppress treatment includ sulfasalazin methotrex sinc diseas control decreas need ophthalm steroid drop previous case found literatur report associ rp cns involv | D008582;D011081 | T047 |
34,663,130 | associ use exchang devic periton dialysi fluid periton incid nationwid cohort studi use exchang devic periton dialysi pd fluid common practic japan evid effect exchang devic prevent pd relat periton scarc evalu associ use exchang devic pd fluid periton incid | D010530;D010538 | T047;T061;T046 |
34,663,129 | antibodi respons sar cov cohort studi qatar primari care set global countri roll sever acut respiratori syndrom coronavirus sar cov quarantin polici vaccin program research studi need help understand likelihood acquir immun reinfect identifi prioriti group vaccin inform studi aim assess period preval longitudin chang antibodi level sar cov infect qatari primari care set | D000086382;D000086402 | T047;T005;T067 |
34,663,128 | orthodont inclin plane applic use visibl light cure acryl materi treatment linguovert mandibular canin teeth malocclus common problem dog linguovert canin teeth class malocclus caus palat defect oronas fistula dental wear periodont diseas mandibular distoclus class ii malocclus mandibular arch occlud caudal normal posit relat maxillari arch contribut lingual displac mandibular canin teeth tradit flowabl self cure bisacryl composit materi use method describ use light cure acryl dentur base materi util multipl custom segment construct applianc desir shape size necessari achiev function inclin plane | D004283;D008310;D008312 | T190;T033;T047;T078 |
34,663,127 | intestin dehisc mortal cat undergo gastrointestin surgeri aim studi determin incid risk factor gastrointestin gi incision dehisc mortal larg cohort cat undergo gi surgeri hypothes cat preoper septic periton psp system inflammatori respons syndrom sir sepsi would higher gi dehisc mortal rate unaffect cat | D013505;D010538;D018805 | T047;T061;T046 |
34,663,126 | success placement complic v gel placement mainten anaesthesia airway manag anaesthesia cat alway demand task associ sever complic aim studi evalu practic complic felin specif laryng mask placement anaesthetis cat altern endotrach intub | D000758;D017214 | T074;T061 |
34,663,125 | optimis endotrach length adult cat retrospect ct studi aim studi determin maxim endotrach insert length measur larynx carina l c distanc mean ct addit object establish certain anatom landmark optimis process endotrach intub eti | D007442;D014132 | T023;T061 |
34,663,124 | preliminari studi ct featur intermedi high grade alimentari lymphoma adenocarcinoma cat ultrasonograph find mani felin intestin tumour similar studi evalu ct featur intermedi high grade alimentari lymphoma adenocarcinoma cat ct perform six cat adenocarcinoma cat lymphoma comparison tumour type conduct focus ct featur includ obstruct present absent growth pattern lesion symmetri asymmetri layer enhanc present absent locat lesion number lesion solitari multipl lymphadenopathi present absent locat lymphadenopathi pulmonari metastasi present absent maximum thick mm lesion cat adenocarcinoma n experienc intestin obstruct signific often cat lymphoma n p layer enhanc observ signific often cat adenocarcinoma n cat lymphoma n p lymphadenopathi detect signific often cat lymphoma n cat adenocarcinoma n p cat lymphoma intestin mm signific thicker cat adenocarcinoma mm p | D000230;D002371;D007414;D000072281;D008223 | T191;T047 |
34,663,123 | pilot random control trial women non small cell lung cancer assess feasibl deliv group base psychosoci care via videoconfer goal pilot random control trial examin feasibl accept deliv group base psychosoci care via videoconfer ie zoom women lung cancer undergo treatment | D002289;D008175;D000067250 | T058;T191;T061 |
34,663,122 | covid skin manifest skin colour coronavirus diseas covid skin manifest increas report medic literatur recent discuss identifi lack imag skin color soc patient covid relat skin find despit peopl skin color disproportion affect diseas call priorit identif covid skin manifest patient soc dissemin find object articl review exist literatur covid skin manifest possibl discuss may present differ patient soc research need allow primari care physician dermatologist awar easili identifi patient cutan find may secondari covid patient present idiopath dermatolog manifest consid covid test follow public health guidelin self isol | D000086382;D012871 | T047;T067 |
34,663,121 | motiv cognit factor pathway offend amongst women sexual offend data driven model address intern motiv pathway offend support cognit amongst women sexual offend emerg recent year signific consequ understand risk factor develop treatment programm current research recent empir base model explor nation sampl consist women commit sexual offenc assess year period n util motiv cognit model test support although case could easili code new categori suggest order better character uniqu aspect sex offend amongst women sexual offend key find includ fewer women expect report coerc male partner frequent conjunct sex intimaci need lack clear relationship offenc relat cognit motiv pathway result support import integr develop gender specif clinic factor within gender neutral treatment paradigm | D009042;D012742 | T041;T048;T037;T078;T080 |
34,663,120 | singular predictor hospit acquir pressur injuri intens care retrospect cohort studi medium complex hospit retrospect cohort studi hospit acquir pressur injuri hapi report incid rate base medic record adult patient admit intens care unit icu medium complex public hospit sixti percent patient use respir present hypotens use norepinephrin main individu predictor hapi icu day norepinephrin odd ratio ci concord statist auc ci day mechan ventil auc icu stay day auc braden sensori percept ci auc durat mechan ventil norepinephrin administr icu length stay present signific discrimin capac hapi predict | D003422;D007362 | T058;T093;T073 |
34,663,119 | audit opportunist lung cancer screen canadian provinc lung cancer lead caus cancer relat death canada earli detect improv outcom despit recommend canadian task forc prevent health care screen patient year old pack year histori formal screen program rare canada goal determin screen perform repres canadian popul recommend follow screen impact lung cancer stage diagnosi prognosi | D055088;D008175 | T058;T191;T060 |
34,663,118 | real world experi vismodegib advanc basal cell carcinoma canadian cancer center vismodegib novel hedgehog pathway inhibitor revolution treatment patient advanc basal cell carcinoma bcc poor candid surgeri radiat studi explor use vismodegib facilit surgeri radiotherapi optim treatment durat balanc outcom advers effect | D000970;D002280;D012878 | T191;T121;T109 |
34,663,116 | toxoplasmosi enceph cross section analysi us safeti net hospit late cart era despit decreas incid toxoplasmosi enceph te among peopl live hiv plwh late antiretrovir era us safeti net hospit still see signific number admiss te littl known popul healthcar util long term outcom conduct year retrospect review plwh te safeti net hospit demograph clinic characterist treatment readmiss outcom collect use chi squar test evalu month caus readmiss demographicclin characterist patient identifi new diagnosi te hiv respect month caus readmiss social factor associ readmiss uninsur p spanish primari languag p non adher p marker clinic sever icu admiss steroid use concomit infect therapeut advers event despit high readmiss rate follow complet respons partial respons improv te outcom requir focus cultur compet coordin care | D004660;D015658;D016781 | T047 |
34,663,114 | develop assist bedsid furnitur earli postop mobil healthcar set attent empathet design approach work endeavor design develop tool assist surgic patient postop mobil hospit | D007374;D010358 | T073;T081;T058;T080;T090 |
34,663,112 | sibl construct matter handl research often studi construct conceptu andor empir relat distinct ie sibl construct social person psycholog well psycholog general littl guidanc deal sibl construct result research ignor mishandl articl start situat sibl construct literatur jingl jangl fallaci outlin conceptu empir criteria determin degre way construct may share sibl relationship use self esteem grandios narciss run exampl final discuss strategi handl sibl construct systemat transpar way hope procedur describ help social person psychologist identifi sibl construct understand pose problem research adopt strategi amelior advers effect | D009289;D035781 | T048;T099 |
34,663,111 | parkinson diseas cognit rate scale greek normat data clinic util cultur consider parkinson diseas cognit rate scale pd crs comprehens screen procedur evalu cognit impair patient parkinson diseas pd | D003072;D060825;D010300 | T048;T047 |
34,663,109 | serum endocan level use earli prognost marker endotheli dysfunct covid studi aim investig whether degre pneumonia covid prognosi associ serum endocan level earli stage vascular damag start patient age year hospit follow diagnosi covid includ studi total patient divid group mildmoder pneumonia sever pneumonia serum endocan level measur th day onset symptom patient patient includ studi femal male signific relationship serum endocan level degre pneumonia p prognosi diseas p correl analysi indic weak posit correl serum endocan level lactat level venous blood gas r p day follow mortal rate determin serum endocan level associ degre pneumonia earli prognost marker covid | D000086382;D014652 | T047;T067 |
34,663,108 | clamp carotid dissect reduc postop stroke carotid endarterectomi background outcom carotid endarterectomi cea constant report multitud studi howev specif caus periop stroke scarc investig aim present studi analyz categor caus periop stroke cea method cea perform singl center collect cea routin perform general anesthesia routin shunt patch use cerebr near infrar spectroscopi monitor carotid exposur techniqu classifi either clamp dissect cd preclamp dissect pcd carotid bifurc dissect prior carotid clamp periop day stroke possibl mechan evalu accord preoper symptom surgic techniqu adopt result among cea perform periop stroke occur identifi upon emerg general anesthesia note first day follow intervent stroke etiolog categor follow technic acut thrombosi intim flap due intraop complic embol recogn technic defect hemorrhag contralater symptomat patient signific higher rate type stroke asymptomat patient vs p cd protect postop stroke vs p symptomat asymptomat patient vs p vs p particular cohort symptomat patient vs p suffer postop embol stroke conclus periop stroke cea may multifactori etiolog includ result technic error cd techniqu may help reduc incid periop stroke | D016893;D016894;D020521 | T047;T061;T020 |
34,663,106 | hospit outdoor space user experi implic design articl aim describ user perspect impact hospit outdoor space patient experi postacut set | D003695;D006761 | T058;T093;T073 |
34,663,104 | rout cocain use affect mortal outcom cocain induc intestin ischemia systemat review intestin ischemia result diminish perfus colon result tissu hypoxia anecdot report suggest cocain induc intestin ischemia highest mortal longer length stay among vasoconstrictor present studi aim summar avail studi literatur assess effect rout consumpt outcom cocain induc intestin ischemia conduct systemat search medlin incept octob studi cocain induc intestin ischemia includ data avail comorbid mortal hospit length stay los studi primari outcom mortal need surgeri secondari outcom includ hospit length stay lace index hospit score statist test use includ linear binari logist regress stata use p statist signific studi case seri case report n patient met inclus criteria differ rout cocain use similar mortal odd need surgeri intestin ischemia hospit los show signific differ among subgroup readmiss score lace hospit score higher intraven smoke ingest intranas use p conclus differ rout cocain use appear similar mortal odd intestin ischemia vari signific among differ rout cocain consumpt length stay readmiss score prompt recognit rout cocain use vital improv outcom larg scale well design observ studi need investig topic | D003042 | T131;T121;T109 |
34,663,103 | evalu impact multisensori environ target behavior children autism spectrum disord worldwid children increas diagnos autism spectrum disord asd case south korea except one core symptom children asd sensori reactiv issu unusu interest sensori aspect environ one promis develop sensori enrich individu asd multisensori environ mse | D000067877 | T048 |
34,663,102 | medic induc gastroparesi case report gastroparesi common diagnos gastrointestin disord high preval global high diseas burden afflict etiolog variabl idiopath diabet common caus gastroparesi manag gastroparesi depend etiolog accur diagnosi requir better target therapi medic induc gastroparesi revers discontinu medic general curat case report discuss case medic induc gastroparesi initi diagnos diabet gastroparesi thorough histori take reveal caus medic induc repeat studi follow medic discontinu reveal improv symptom resolut gastroparesi research need done assess frequenc misdiagnos diabet patient gastroparesi due medic specif glucagon like peptid receptor agonist increas use diabet | D003920;D018589 | T047 |
34,663,099 | infecti sar cov emit aerosol particl respiratori virus sar cov transmit respiratori droplet aerosol particl releas talk breath cough sneez noncontact transmiss sar cov demonstr suggest transmiss via virus carri air demonstr golden syrian hamster produc infecti sar cov aerosol particl prior concurr onset mild clinic sign diseas averag emiss rate studi infecti virionshour day postinocul averag viral rna level fold higher infecti virus aerosol particl major virus contain within particl size thus provid direct evid hamster sar cov airborn virus import sar cov respiratori virus isol air near covid patient use hamster model infect demonstr sar cov emit aerosol particl prior concurr onset mild diseas virus contain primarili within aerosol particl size remain airborn inhal find indic sar cov airborn virus support use ventil reduc sar cov transmiss | D000336 | T122 |
34,663,098 | train innat immun induc vaccin low virul candida speci mediat protect sever form fungal sepsi via lyg gr leukocyt recent discov novel form train innat immun tii induc low virul candida speci ie candida dubliniensi protect lethal fungalbacteri infect mice vaccin intraperiton ip inocul protect lethal sepsi follow candida albican staphylococcus aureus ca sa intra abdomin infect iai ca bloodstream infect bsi protect iai mediat long live gr leukocyt putat myeloid deriv suppressor cell mdscs prototyp train macrophag studi aim determin similar tii mechan gr cell mediat suppress sepsi protect bsi whether tii also induc follow intraven iv vaccin mice vaccin low virul candida strain ip iv follow lethal challeng ca sa ip ca iv day later observ sepsi hypothermia sepsi score serum cytokin organ fungal burden mortal similar paramet monitor follow deplet macrophag gr leukocyt lethal challeng result show mice vaccin ip iv protect lethal ca sa iai ca bsi case protect mediat lyg gr putat granulocyt mdscs g mdscs role macrophag correl reduc sepsi paramet protect also correl reduc fungal burden spleen brain liver kidney result suggest lyg g mdsc mediat tii induc either ip iv rout inocul protect iai bsi form system candidiasi surviv correl amelior sepsi reduc organ specif fungal burden import train innat immun tii induc follow immun live attenu microb repres clinic import strategi enhanc innat defens tii initi demonstr follow intraven inocul low virul candida albican protect subsequ lethal c albican intraven bloodstream infect bsi mediat monocyt enhanc cytokin respons expand describ novel form tii induc intraperiton inocul low virul candida protect lethal sepsi induc polymicrobi intra abdomin infect iai via gr leukocyt putat myeloid deriv suppressor cell mdscs studi address two scenario confirm exclus role lyg gr leukocyt mediat tii either iai bsi via either rout inocul protect associ suppress sepsi studi highlight previous unrecogn import lyg mdscs central mediat novel form tii term train tolerogen immun | D007113 | T032 |
34,663,097 | develop evalu cryopreserv whole parasit vaccin rodent model blood stage malaria infect malaria parasit continu major global public health issu current control measur enabl signific decreas morbid mortal last year addit tool requir progress toward malaria parasit erad malaria vaccin research focus develop subunit vaccin howev recent interest whole parasit vaccin reignit whole parasit vaccin enabl present broad repertoir antigen immun system limit impact antigen polymorph genet restrict immun respons previous report whole parasit vaccin prepar use chemic attenu parasit within intact red blood cell use kill parasit liposom although liposom less immunogen attenu parasit could frozen freez dri made immunogen liposom vaccin would ideal vaccin deploy area malaria endem develop evalu plasmodium yoelii liposom vaccin enhanc immunogen efficaci due incorpor tlr agonist acyl phad mannos target liposom antigen present cell follow vaccin mice protect strong cellular immun respons induc character parasit specif splenocyt prolifer mix ththth cytokin respons parasit specif antibodi induc predomin igg subclass cd cell gamma interferon critic compon protect immun respons studi repres import develop toward evalu whole parasit blood stage vaccin phase clinic trial import malaria mosquito born infecti diseas caus parasit genus plasmodium seven differ plasmodium spp caus malaria human p falciparum caus major morbid mortal malaria parasit endem countri continu result million case malaria deathsyear most children year age malaria infect initi present flu like ill rapid progress sever diseas nonimmun individu treatment initi prompt exist control strategi mosquito vector insecticid parasit antimalari drug becom increas less effect due develop resist artemisinin combin therapi frontlin treatment p falciparum malaria resist document numer countri high effect malaria vaccin urgent requir reduc malaria attribut clinic diseas death enabl progress toward ultim goal erad | D007111;D000071497 | T040;T038;T043 |
34,663,094 | adenylyl cyclas protein kinas play redund distinct role growth differenti antifung drug resist pathogen candida auri candida auri global emerg multidrug resist fungal pathogen pathogen relat signal network larg unknown character pathobiolog function cyclic amp camp protein kinas pka signal pathway c auri focus adenylyl cyclas cyr pka regulatori subunit bci pka catalyt subunit tpk tpk conclud pka act depend independ cyr c auri tpk tpk major minor role respect pka activ function cyr pka promot growth thermotoler filament growth resist stress antifung drug regul express multipl effector gene addit cyr pka subunit involv disinfect resist c auri howev delet tpk tpk general result sever defect cyr delet indic cyr pka play redund distinct role notabl tpk tpk redund cyr independ role haploid diploid cell transit increas virul c auri howev tpk tpk often play oppos role format biofilm cell wall compon chitin chitosan surpris delet cyr tpktpk result sever vitro growth defect c attenu virul bci delet reduc virul c auri system murin infect model conclus studi provid comprehens insight role camppka pathway drug resist pathogen c auri suggest potenti therapeut option treatment c auri mediat candidemia import despit recent grow concern pan resist candida auri infect pathogen ascomycet fungal pathogen signal circuitri govern resist antifung drug larg unknown therefor analyz pathobiolog function cyclic amp camp protein kinas pka signal pathway c auri play conserv role growth virul fungal pathogen show adenylyl cyclas cyr pka pleiotrop role growth morphogenesi stress respons antifung drug disinfect resist ploidi shift c auri notabl howev observ tpk tpk mutant general exhibit disrupt phenotyp cyr mutant suggest tpk tpk camp depend independ role pathogen surpris observ hyperactiv inhibit camppka pathway reduc virul c auri base result suggest discuss potenti therapeut strategi candidiasi caus c auri | D025141;D015398 | T044;T032;T043 |
34,663,093 | divers equiti inclus microbi scienc texa perspect way divers equiti inclus impact scientif career vari everyon evid institut provid environ differ differ creat sens welcom support valu benefici scientif communiti larg commentari three short stori texa base microbiologist use depict import bring guid principl divers equiti inclus within profession role ii need appli translat principl support enabl success scientif career among peer traine iii impact effect scienc communic increas understand microbi environ among communiti larg | D018864;D008829 | T091;T077;T078 |
34,663,092 | pleiotrop effect p type atpas spfa stress respons network contribut virul pathogen mold aspergillus fumigatus aspergillus fumigatus human pathogen mold extract nutrient environ host tissu secret hydrolyt enzym abil fumigatus adjust secret level proport demand reli assist unfold protein respons upr adapt stress respons pathway regul uniqu protein fold environ endoplasm reticulum er p type atpas spf recent implic novel mechan er homeostasi involv correct error er membran protein target howev contribut protein biolog fumigatus unknown employ gene knockout rna sequenc strategi determin function role fumigatus gene code ortholog p atpas spfa data reveal spfa gene induc er stress upr depend manner absenc spfa fumigatus transcriptom shift toward profil alter redox lipid balanc addit signatur er stress includ srca encod second p type atpas er spfa delet mutant show increas sensit er stress oxid stress antifung drug target cell wall plasma membran combin loss spfa srca exacerb phenotyp attenu virul two anim infect model find demonstr er resid atpas spfa srca act joint support divers adapt function er necessari fit host environ import fungal upr adapt signal pathway er buffer fluctuat er stress also serv virul regulatori hub speci pathogen fungi reli secretori pathway homeostasi pathogen studi demonstr gene encod er local p type atpas spfa downstream target upr pathogen mold fumigatus work togeth second er local p type atpas srca support er homeostasi oxid stress resist suscept antifung drug virul fumigatus | D059865;D015398 | T049;T044;T043 |
34,663,091 | rapid prolifer pandem research implic dual use risk covid pandem demonstr world vulner biolog catastroph elicit unpreced scientif effort work deriv howev present dual use risk ie potenti harm misappl benefici research larg gone unaddress instanc gain function studi revers genet protocol may facilit engin concern sar cov variant pathogen risk accident deliber releas danger pathogen may increas larg scale collect character zoonot virus undertaken effort understand enabl anim human transmiss concern exacerb rise preprint publish circumv late stage opportun dual use oversight prevent next global health emerg must avoid inadvert increas threat futur biolog event requir nuanc proactiv approach dual use evalu throughout research life cycl includ concept fund conduct dissemin research | D003264 | T057 |
34,663,090 | alway better doubl head role fibronectin staphylococcus aureus host cell invas staphylococcus aureus classic consid extracellular pathogen bacteria also capabl taken host cell includ nonprofession phagocyt endotheli cell epitheli cell osteoblast intracellular aureus lifestyl contribut infect develop predomin recognit intern pathway appear bind bacteria via fibronectin bridg integrin host cell membran follow phagocytosi although osteoblast show high express integrin fibronectin bacteria adher osteoblast high proport demonstr intern assay immunofluoresc microscopi aureus less engulf osteoblast epitheli cell addit exogen fibronectin infect cell aureus result increas uptak epitheli cell osteoblast contrast previous concept uptak mechan high express integrin fibronectin would promot bacteri uptak host cell extracellular fibronectin surround osteoblast epitheli cell organ fibrillari network inhibit fibril format short interf rna mediat reduct fibronectin express disrupt fibronectin fibril meshwork result signific increas aureus uptak osteoblast thus network fibronectin fibril appear strong reduc uptak aureus given host cell indic supramolecular structur fibronectin determin capac particular host cell intern pathogen import tradit staphylococcus aureus consid extracellular pathogen howev among factor frequent failur antimicrobi therapi abil pathogen caus recurr diseas establish concept eukaryot invas pathogen therebi evad host immun system current model host cell invas bacteria initi bind integrin host cell side via fibronectin bridg eventu lead phagocytosi aureus host cell howev studi demonstr crude amount supramolecular structur fibronectin molecul deposit eukaryot cell surfac play essenti role bacteri uptak host cell find explain larg differ aureus uptak efficaci differ host cell type well vivo differ cours bacteri infect local bacteria differ clinic set | D000076662 | T070 |
34,663,087 | robot assist laparoscop distal ureteroureterostomi distal benign ureter strictur long term follow object demonstr feasibl robot assist laparoscop ral ureteroureterostomi uu benign distal ureter strictur dus robot reconstruct seri long term follow patient method retrospect review prospect maintain ral ureter reconstruct databas follow patient june februari underw uu dus addit patient demograph record etiolog strictur length recurr rate recurr defin find recurr persist obstruct postop mercaptoacetyltriglycin diuret renal scan need addit intervent ureter drainag revision surgeri result identifi patient underw ral uu dus benign etiolog median age year interquartil rang iqr patient women median strictur length cm iqr iatrogen surgic injuri note patient ureter reconstruct perform use ral postop imag consist renal ultrasonographi diuret renal scan cross section radiolog within month index oper imag depend clinic judgment twenti patient success median follow time month two recurr necessit ral ureteroneocystostomi unc conclus ral uu dus technic viabl show promis efficaci proper select patient techniqu may serv nich preserv natur anatom drainag bladder uret addit obviat sequela vesicoureter reflux seen unc | D010535;D065287;D012371;D014513;D014517 | T023;T047;T061;T060;T090 |
34,663,086 | molecular featur hypertroph scar thermal injuri biolog basi laser therapi signific hypertroph scar hts keloid common thermal injuri trauma deep region dermi skin abnorm scar caus contractur thick mass scar tissu result function cosmet impair manag dermal fibrot condit includ wide rang medic surgic treatment time consum partial effect often uncomfort patient recent advanc molecular pathophysiolog hts becom understood past two decad thermal injuri reticular dermi result inflammatori respons fibrogen growth factor releas format dermal scar increas collagen proteoglycan composit abnorm morpholog laser becom wide use form treatment type scar howev evid benefici effect laser treatment understand mechan action still evolv critic issu paradox laser deliveri thermal energi skin suggest improv scar remodel wound heal yet hts well recogn complic excess thermal energi deliv laser treatment review aim examin current evid use laser hts investig molecular mechan injuri burn scar laser treatment could result overal improv scar qualiti futur direct improv design clinic trial treatment scar futur evolv new methodolog model hts anim human | D001688;D002056;D017439;D007627;D053685 | T121;T123;T074;T061;T020;T037 |
34,663,084 | contemporari analysi ureter reconstruct day morbid util nation surgic qualiti improv program databas comparison minim invas vs open approach object character day morbid upper ureter reconstruct uur lower ureter reconstruct lur surgeri compar open minim invas surgeri mis approach use nation surgic outcom registri method american colleg surgeon nation surgic qualiti improv program databas review patient underw uur lur primari endpoint includ day complic transfus readmiss return oper room ror prolong postop length stay los multivari logist regress perform observ associ mis approach day outcom result three thousand forti two patient identifi undergo uur undergo lur patient undergo uur perform mis approach multivari analysi open approach uur associ increas odd day complic odd ratio p major complic p transfus p ror p prolong los p patient undergo lur perform mis approach multivari analysi open approach lur associ increas odd day complic p minor complic p transfus p prolong los p conclus util nation surgic databas reveal open approach associ increas day morbid across multipl postop outcom measur find suggest mis approach consid feasibl upper lower ureter reconstruct | D058996;D014513 | T023;T057 |
34,663,083 | trend sociodemograph hospit level factor associ palliat care util among multipl myeloma patient use nation inpati sampl sever factor report associ palliat care util among patient various cancer literatur lack multipl myeloma mm specif factor mm patient high symptom burden earli involv palliat could increas qualiti life examin factor associ palliat care util among mm patient explor preval trend palliat care util among patient mm | D009101;D010166 | T191;T061 |
34,663,082 | patient mild post oper hyponatraemia follow elect arthroplasti discharg safe larg scale servic evalu suggest post oper hyponatraemia common follow arthroplasti clinic hyponatraemia guidelin lack detail treatment necessari pauciti literatur guid best practic | D007010 | T047 |
34,663,080 | complic radic nephrectomi accord age analysi british associ urolog surgeon nephrectomi audit introduct compar complic rate radic nephrectomi rn renal cell carcinoma rcc across differ age group method retrospect analysi british associ urolog surgeon nephrectomi audit databas januari decemb perform comparison made differ age group patient undergo rn rcc result eighteen thousand four hundr thirti eight patient rcc underw rn year age year age year age signific lower preoper hemoglobin estim glomerular filtrat rate advanc age p patient higher charlson comorbid index world health organ perform status p also signific variabl approach rn p laparoscopi common perform vs vs patient year age found shortest oper time p signific differ stage group patient year age higher stage p incid intraop complic signific differ age group p incid postop complic major postop complic patient year age respect p common complic age group blood transfus year age stepwis logist regress analysi adjust addit variabl found odd postop complic increas age odd ratio patient year age odd ratio patient year age compar year age conclus overal complic age group low advanc age consid independ risk factor postop complic rn appropri consid counsel elder patient treatment | D002292;D007680;D066231 | T097;T191 |
34,663,077 | statin use associ postop estim glomerular filtrat rate patient undergo robot assist partial nephrectomi object evalu associ preoper statin use chang estim glomerular filtrat rate egfr robot assist partial nephrectomi rapn method three hundr eighti nine consecut patient undergo rapn evalu associ preoper statin use chang egfr pre rapn postop day pod month rapn evalu use longitudin mix effect regress model random patient specif intercept slope account imbal preoper patient tumor characterist group stabil invers propens score weight postop egfr chang baselin measur total chang maintain egfr within baselin go egfr mlmin mlmin result one hundr sixti seven patient statin therapi preoper statin patient older vs year higher rate comorbid includ diabet mellitus vs hypertens vs statin patient tend lower preoper egfr mean standard deviat vs mlmin evid associ preoper statin use chang egfr time point rapn p conclus patient preoper statin undergo rapn lower egfr preoper compar take medic evid associ preoper statin use chang post rapn egfr immedi postop period year surgeri | D005919;D019161;D009392;D065287 | T061;T121;T060;T109 |
34,663,076 | ambulatori percutan nephrolithotomi may cost effect compar standard percutan nephrolithotomi background coronavirus diseas covid chang practic medicin america march lockdown elect case cancel conserv hospit bedsresourc result financi loss health system delay surgic care ambulatori percutan nephrolithotomi apcnl shown safe could strategi ensur patient receiv care delay conserv hospit resourc maxim cost effect aim compar safeti cost effect patient undergo apcnl standard pcnl spcnl materi method ninti eight patient underw pcnl indiana univers methodist hospit tertiari referr center three expert surgeon januari septemb primari outcom studi compar day rate emerg depart ed visit readmiss complic spcnl apcnl secondari outcom includ cost analysi stone free rate sfrs propens score match perform ensur group balanc statist analys perform use sas use independ test continu variabl chi squar analys categor variabl result nineti eight patient underw pcnl studi period spcnl apcnl propens score match patient avail comparison spcnl apcnl found differ day ed visit readmiss complic two group apcnl result cost save per case sfrs higher apcnl compar spcnl conclus apcnl appear safe perform higher rate ed visit readmiss compar spcnl apcnl may also cost effect compar spcnl | D000086382;D007669;D000074642;D009403 | T047;T061;T067 |
34,663,074 | endoscop full thick resect gastric schwannoma year old male refer center evalu treatment gastric mass esophagogastroduodenoscopi found mm submucos tumor smt gastric bodi endoscop ultrasound reveal hypoecho lesion origin musculari propria layer comput tomographi show tumor present predomin intralumin growth pattern | D000069916;D009442;D013274 | T191;T061 |
34,663,073 | case covid concomit infect hepat symptom covid rang mild sever pulmonari manifest common howev liver injuri rare might reciproc influenc covid hepat diseas high level liver enzym associ increas preval sever complic search etiolog hepat diseas ignor report case covid present acut fulmin hepat hav without previous histori | D000086382;D006506;D017114;D016031 | T047;T061;T067 |
34,663,070 | precis biotransform emerg pollut human cytochrom p use comput experiment synergi case studi tris dichloro propyl phosphat precis biotransform envis strategi offer detail insight biotransform pathway real environment set use experiment guid high accuraci quantum chemistri emerg pollut whose metabolit easili overlook may caus idiosyncrat toxic import target strategi demonstr complex metabol reaction tris dichloro propyl phosphat tdcipp catalyz human cyp enzym map via three step synergi strategi screen possibl metabolit via high throughout moder accuraci comput ii analyz propos metabolit vitro human liver microsom recombin human cyp enzym iii ration experiment data via precis mechan use high level target comput bilater dialogu qualit semi quantit quantit level show tdcipp metabol especi cypa generat bis dichloro propyl phosphat bdcipp dealkyl metabolit bis dichloro propyl chloro hydroxi propyl phosphat alcohol dehalogen dehalogenationreduct metabolit via initi rate determin h abstract c c posit relat yield ratio dehalogenationreduct dealkyl deriv relat barrier h abstract c c posit cypa estim viz vitro measur ratio import alcohol dehalogen format point new mechan involv success oxid reduct function cyp precursor aldehyd dehalogen key intermedi detect trap assay ration comput conclud propos three step synergi strategi may meet increas challeng elucid biotransform mechan substanti synthes organ compound futur | D004785;D005411 | T131;T120 |
34,663,069 | topproperti robust metapredict transmembran globular protein featur use deep neural network transmembran protein tmps critic compon cellular life howev due experiment challeng number experiment resolv tmp structur sever underrepres databas compar cellular abund predict per residu featur transmembran topolog membran exposur secondari structur solvent access use start point experiment design protein structur predict often requir differ comput tool differ featur type protein present topproperti metapredictor predict featur tmps globular protein topproperti train dataset without bias toward high number sequenc homolog predict signific better evalu state art primari predictor qualiti metric topproperti elimin need protein type featur tailor tool specif tmps topproperti freeli avail web server standalon https cpclabuni duesseldorfdetopsuit | D016571 | T170 |
34,663,067 | chemic synthesi full length g protein coupl receptor adrenerg receptor defin modif pattern c terminus adrenerg receptor ar g protein coupl receptor gpcr respond hormon adrenalin import drug target context respiratori diseas includ asthma ar function regul post translat modif phosphoryl ubiquitin c terminus access full length ar well defin homogen modif pattern critic biochem biophys studi remain challeng report practic synthesi differenti modifi full length ar base combin nativ chemic ligat ncl sortas ligat strategi array homogen sampl full length ar distinct modif pattern includ full length ar bear monoubiquitin octaphosphoryl modif success prepar first time use homogen modifi full length ar receptor found differ phosphoryl pattern mediat differ interact arrestin reflect differ agonist bind affin experi also indic ubiquitin modul interact ar arrestin access full length ar well defin homogen modif pattern c terminus open door depth mechanist studi structur dynam ar complex downstream transduc protein includ g protein arrestin gpcr kinas | D011499 | T044 |
34,663,065 | control self assembl dna mimick nanotub form layer layer scaffold homeostat tissu construct various biomateri scaffold develop improv stem cell anchorag function tissu construct vitro vivo use growth factor typic appli scaffold mediat cell differenti convent growth factor strict local scaffold thus may leak surround environ caus undesir side effect tissu cell henc need improv tissu construct strategi base high local drug deliveri homeostat microenviron studi develop inject nanomatrix nm scaffold layer layer structur insid nanos fiber scaffold base control self assembl molecular level nm hierarch assembl janus base nanotub jbnts matrilin transform growth factor tgf via bioaffin jbnts form nm backbon novel dna inspir nanomateri mimic natur helic nanostructur collagen chondrogen factor tgf envelop inner layer insid nm fiber prevent releas matrilin incorpor outer layer creat cartilag mimick microenviron maintain tissu homeostasi interest human mesenchym stem cell hmscs strong prefer anchor along nm fiber form local homeostat microenviron therefor nm success generat high organ structur via molecular self assembl achiev local drug deliveri stem cell anchorag homeostat tissu construct | D023822 | T061 |
34,662,930 | spatial tempor pattern prostat cancer burden associ socio demograph index asia prostat cancer second frequent diagnos cancer male worldwid spatial tempor trend prostat cancer burden remain unknown asia studi aim investig chang spatial tempor trend incid preval mortal disabl adjust life year dali mortal incid ratio mir prostat cancer associ socio demograph index sdi asian countri | D000071219;D006301;D062211 | T057;T098;T081;T080;T062 |
34,662,928 | stratif obes class rather age identifi higher percent children risk non alcohol fatti liver diseas metabol dysfunct increas number clinic practic guidelin recommend screen children obes non alcohol fatti liver diseas nafld howev limit evid regard paramet use initi screen | D065626 | T047 |
34,662,927 | student mental health higher educ contextu influenc cut competit comparison mental health student uk higher educ receiv increas attent support servic student increas pressur | D008603;D013334 | T098;T041;T081 |
34,662,926 | comparison extraperiton laparoscop extraperiton senhanc radic prostatectomi senhanc novel robot platform use perform radic prostatectomi rp compar result robot rp similar patient oper laparoscop techniqu | D010535;D011471;D065287 | T061;T191;T060 |
34,662,924 | critic assess vitro screen glucosidas inhibitor plant acarbos refer standard postprandi hyperglycemia treat oral antidiabet drug acarbos intestin glucosidas inhibitor side effect acarbos motiv grow number screen studi identifi novel glucosidas inhibitor deriv plant extract natur sourc gold standard acarbos frequent includ refer standard assess potenc candid glucosidas inhibitor mani outperform acarbos sever order magnitud result subsequ use identifi suitabl compoundsproduct strong potenti vivo efficaci howev glucosidas inhibitor screen studi use enzym prepar obtain nonmammalian sourc typic saccharomyc cerevisia despit strong evid inhibit data obtain use nonmammalian glucosidas may hold limit valu term identifi glucosidas inhibitor actual vivo hypoglycem potenti aim critic discuss screen novel glucosidas inhibitor plant sourc emphas inconsist pitfal specif acarbos includ refer standard assess avail literatur emphas crucial state biolog sourc glucosidas screen studi allow unambigu ration interpret data review also highlight lack univers adopt screen assay novel glucosidas inhibitor commerci avail standard prepar mammalian glucosidas | D020909;D065089 | T121;T109 |
34,662,923 | dissoci visual loss children adolesc psychogen vision disord children adolesc common disord primarili encount ophthalmologist onset disord dissoci present suggest neurolog somat condit loss visual acuiti blur vision visual field restrict often describ tunnel vision appear typic onset may sudden frequent relat wide rang stress life event school failur famili conflict accid major children quick recov symptom substanti percentag experi persist symptom fluctuat cours due lack efficaci studi specif treatment protocol diagnost work treatment suffer high degre uncertainti differenti dissoci visual loss physic ill requir special expertis uncertainti ophthalmologist specialist involv deal clinic condit often delay specialis treatment may also trigger inadequ therapi iatrogen risk harm patient articl primarili describ disord specif psychiatr diagnost well somat differenti diagnost work outlin therapeut principl dissoci visual loss | D013001;D014786 | T033;T048;T047;T184 |
34,662,922 | colour vision disord due convers disord childhood non organ vision loss manifest various way common form reduc vision visual field defect colour vision disord context convers disord rare report | D055253;D003117;D003291 | T040;T048;T047 |
34,662,921 | topic timolol infantil haemangioma orbit infantil haemangioma ih common benign tumour eyelid orbit infanc beta blocker form oral propranolol becom first line treatment sever case function signific disfigur ih howev advers drug reaction oral propranolol infant report serious potenti life threaten system side effect includ dyspnoea hypotens hyperkalaemia hypoglycaemia cyanosi therefor requir care close monitor cours system treatment recent two larg meta analys shown topic beta blocker timolol maleat effect oral propranolol superfici ih signific fewer advers effect advoc topic beta blocker replac oral propranolol first line treatment superfici ih previous report therapeut respons deep periocular ih primari topic timolol maleat monotherapi also describ first success treatment larg orbit ih primari topic timolol maleat monotherapi four infant result immedi cessat progress rapid clinic improv resolut case advers effect recurr long term follow year cessat seen patient treat topic timolol maleat | D006391;D013999 | T191;T121;T109 |
34,662,920 | adapt bag len implant techniqu children congenit ectopia lenti sublux crystallin len childhood confront surgeon dilemma oper wait see surgeri usual perform sublux still limit howev postpon surgeri increas surgic difficulti capsular bag becom difficult use mean support intraocular len iol larg number children alreadi present pronounc sublux first present paper describ techniqu optimis centrat fixat bag len bil iol children younger year age congenit ectopia lenti | D004479;D007910 | T074;T019 |
34,662,918 | non vitamin k antagonist oral anticoagul coronari arteri diseas prevent atherothrombot event primari goal treatment patient arteriosclerot disord despit recent improv manag coronari arteri diseas cad revascular techniqu antiplatelet therapi patient remain risk recurr cardiovascular event could relat addit thrombin generat result interest develop novel therapi prevent thromboembol event target thrombin mediat pathway includ non vitamin k antagonist oral anticoagul noac articl aim summar recent clinic studi investig role noac cad | D000925;D001281;D003324;D020521;D013923 | T047;T121;T046 |
34,662,917 | amino methyl nitrophenyl dihydropyrano c pyrazol carbonitril show antihypertens vasorelax action via calcium channel blockad sever h pyran deriv design synthes previous vasorelax agent potenti antihypertens drug context object present investig determin function mechan vasorelax action amino methyl nitrophenyl dihydropyrano c pyrazol carbonitril vivo antihypertens effect thus compound show signific vasorelax action isol aorta rat ring pre contract serotonin noradrenalin effect endothelium depend compound induc signific relax effect aortic ring contract kcl mm indic main mechan action relat l type calcium channel blockad last corrobor sinc compound induc signific concentr depend lower contract provok cumul cacl ad moreov compound capabl block contract induc fpl specif l type calcium channel agonist concentr depend manner hand dock studi reveal compound interact two possibl site l type calcium channel better affin energi kcalmol best pose nifedipin kcalmol final compound mgkg show signific antihypertens activ lower systol diastol blood pressur spontan hypertens rat shr without modifi heart rate | D000959;D014665 | T121 |
34,662,916 | pulmonari embol pulmonari embol pe life threaten diseas third frequent cardiovascular caus death stroke myocardi infarct annual incid increas germani case per popul year case per popul year individu risk pe relat complic death increas number comorbid sever right ventricular dysfunct use clinic laboratori imag paramet patient pe stratifi four risk class high intermedi high intermedi low low risk risk stratif concret therapeut consequ rang hospit treatment low risk patient reperfus treatment intermedi high risk patient haemodynam unstabl patient treatment decis prefer made interdisciplinari pulmonari embol respons team pert due compar efficaci prefer safeti profil compar vitamin k antagonist vkas non vitamin k depend oral anticoagul noac increas consid treatment choic initi prolong anticoagul patient pulmonari embol use low molecular weight heparin lmwhs recommend pe patient cancer howev recent studi indic treatment factor xa inhibitor may effect safe patient without gastrointestin cancer prolong anticoagul reduc dosag ensur reduct vte recurr thus consid patient unprovok event | D000925;D011655 | T047;T121;T046 |
34,662,912 | sperm dna fragment sperm dna fragment refer accumul adduct well singl doubl strand dna break reflect sperm dna qualiti current data suggest differ sperm dna qualiti among individu high low fertil observ led idea test sperm dna fragment could use test male fertil howev sperm dna fragment becom one frequent debat topic reproduct medicin agreement optim way test dna fragment clinic signific level sperm dna fragment well best therapeut option infertil men articl present current evid relat sperm dna fragment role manag male infertil | D007248;D013094 | T033;T047;T184;T025 |
34,662,911 | simultan endoscop microscop visual microvascular decompress hemifaci spasm hemifaci spasm hfs social limit condit lead decreas qualiti life treat microvascular decompress mvd endoscopi describ adjunct tradit microscopi mvd although best visual techniqu debat | D019569;D061145 | T033;T047;T061 |
34,662,910 | novel system simul model aneurysm clip train descript model assess face content construct valid aneurysm clip simul model need provid tactil feedback biolog vessel nonhazard surgic relev environ | D002532;D019635;D000066908 | T065;T047;T046;T190;T061 |
34,662,909 | earli outcom endoscop third ventriculostomi choroid plexus cauter versus ventriculoperiton shunt primari treatment hydrocephalus children myelomeningocel prospect cohort studi myelomeningocel associ hydrocephalus case hydrocephalus usual treat insert ventriculoperiton shunt howev grow evid endoscop third ventriculostomi etv choroid plexus cauter cpc altern | D006849;D008591;D020542 | T047;T019;T020;T033;T030 |
34,662,908 | intrapulp concentr hydrogen peroxid teeth restor bulk fill convent bioactiv composit studi evalu intrapulp concentr hydrogen peroxid hp penetr interfac teeth restor bioactiv composit use convent bulk fill composit cylindr caviti prepar buccal surfac bovin incisor crown n restor resin modifi glass ionom rmgi riva light cure sdi non bioactiv bulk fill composit fb filtek bulk oral care non bioactiv convent composit fz filtek z oral care bioactiv bulk fill composit ac activa bioactiv pulped bioactiv convent composit bii beautifil ii shofu thermal cycl restor n expos high hp applic minsess session low hp minday day concentr bleach protocol last bleach applic hp intrapulp concentr determin addit teeth restor pigment rhodamin b solut hp penetr around interfac observ laser scan confoc fluoresc microscopi lscfm n presenc gap interfac observ replica cross section sampl scan electron microscopi sem n data submit one way gap analysi twoway analysi varianc anova hp intrapulp concentr tukey test lscfm imag qualit analyz restor teeth submit hp present higher hp intrapulp concentr teeth submit hp p expos hp lower hp intrapulp concentr observ teeth restor rmgi expos hp compar teeth restor nonbioact convent fz p bulk fill composit fb p gap format observ outer enamel adhes interfac restor materi lscfm imag show hp promot greater degrad rhodamin b enamel except rmgi context rmgi promot lower hp intrapulp concentr non bioactiv convent bulk fill composit | D003793;D006861 | T130;T121;T122;T197 |
34,662,905 | qlone simpl method creat degre photogrammetri base dimension model cadaver specimen human cadav essenti compon anatomi educ howev access cadaver specimen laboratori facil limit part world henc new innov approach access technolog much need enhanc anatomi train | D021621;D008953 | T062;T170;T073;T060 |
34,662,904 | nudt variant confer high incid second malign children acut lymphoblast leukemia effect genet variat second malign neoplasm smns remain unclear first identifi pathogen germlin variant cancer predispos gene among children smns childhood leukemialymphoma use whole exom sequenc preval low focus associ smns nudt primari acut lymphoblast leukemia case nudt one mercaptopurin mp metabol gene variant common east asian individu preval nudt hypomorph variant higher patient smns n general popul gnomad databas p valid studi cohort unselect patient cumul incid smns signific higher among confid interv ci among without nudt variant ci p mp dose administ patient nudt variant higher given without smns p mp relat mutat signatur observ smn specimen mp exposur cell expos mp higher level mp induc dna damag nudt knockdown induc pluripot stem cell studi indic nudt variant may confer risk smns treatment mp patient | D016609;D054198 | T191 |
34,662,902 | perspect creatin condit essenti nutrient build case creatin major compon energi metabol abund human skelet muscl brain heart either synthes intern provid via omnivor diet creatin requir normal growth develop health recent advanc creatin nutrit physiolog suggest quantiti creatin bodi natur synthes suffici meet human need result human obtain enough creatin diet nomin creatin essenti nutrient certain circumst articl summar argument creatin consid condit essenti nutrient human propos sever question address futur research | D003401;D004032 | T116;T168;T123 |
34,662,900 | perspect unpack wick challeng altern protein unit state high process plant base cell cultur food beverag product support healthi sustain diet food system past decad plethora altern protein ap product enter us food system plant base food beverag product ap product includ plant base meat dairi altern cell cultur meat seafood product develop marketplac simul appear textur tast flavor nutrit profil anim product new generat ap plant base cell cultur food beverag product part market driven narrat embrac technolog address futur human health environment ethic planetari health challeng perspect articl synthes evid benefit adopt minim process plant base diet support sustain food system human planetari health thereaft examin wick challeng relat ap product us context includ confus market landscap public divers view vari accept among consum health environment benefit product inadequ educ label provid feder agenc enabl consum understand may support healthi sustain diet slow feder polici regulatori action address rang ap product provid industri guidanc articl conclud suggest polici action govern agenc food system actor address challeng futur research action need balanc human health equiti anim welfar econom viabil goal clarifi ap product may support safe healthi sustain diet food system | D004032;D000074421 | T168 |
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