PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,662,766 | perform studi foul resist novel ultrafiltr membran base blend poli ether ether sulfon poli vinyl pyrrolidon nano titania separ humic acid dye biolog macromolecular protein aqueous solut studi explain use ultrafiltr membran made polyvinyl pyrrolidon pvp poli ether ether sulfon pee nano titania n tio separ organ compound result test poros water content surfac chemistri membran morpholog contact angl demonstr develop membran hydrophil pee membran due redund hydrophil natur pvp n tio membran pure water flux contain wt pvp wt n tio lm h three fold higher pristin membran lm h employ bovin serum albumin model foulant foul resist peespvpn tio membran examin accord analysi flux recoveri ratio irrevers resist modifi membran less like foul peesn tio membran pvp addit recommend optim fabric membran effect remov various organ compound humic acid safranin egg albumin pepsin trypsin aqueous solut permeabl safranin humic acid peespvpn tio membran lm h lm h respect | D006812;D014462 | T061;T109;T123 |
34,662,765 | pattern travel care factor influenc obstetr referr evid nigeria urbanis state critic referr make imper studi pattern factor influenc health system level studi referr lago nigeria base health record pregnant women present obstetr emerg one comprehens emerg obstetr care emoc facil state novemb octob complement distanc time data extract googl map univari bivari multivari analys conduct quarter pregnant women present obstetr emerg refer referr primari health centr privat public hospit apart expect low level high level referr pattern pattern observ includ non formal multipl post deliveri referr travel time distanc facil could provid need care increas two fold account referr compar scenario go direct final facil most travel facil privat carstaxi prolongedobstruct labour commonest obstetr indic referr major refer pregnant women deliv via caesarean section adjust marri regist antenat care facil care present night foetus distress increas odd referr howev pariti present month follow commiss new comprehens emoc facil abort reduc likelihood refer find underscor need health system strengthen intervent support women referr import antenat care earli book aid identif potenti pregnanc complic whilst establish robust birth prepared plan minimis need referr event emerg inde context specif influenc need address effect referr system design | D002585;D012017 | T079;T097;T170;T061;T058 |
34,662,764 | religi faith sexual risk take among adolesc emerg adult meta analyt review although evid religi faith may offer protect sexual risk take adolesc emerg adulthood attempt made systemat quantifi associ | D012309;D012725 | T032;T053;T055 |
34,662,763 | theoris hospic gaze foucauldian collabor ethnographi palliat day care servic foucault medic gaze minim appli palliat care analysi key polici document paper develop conceptualis foucault medic gaze use empir data gather group ethnographi hospic daycar centr use foucault medic gaze theoret aporia conceptualis hospic gaze argu hospic gaze antithesi foucauldian medic gaze suggest oper reflex profession adapt patient rather patient profession direct toward enabl patient love one narrat sever ill death way develop patient centr narrat structur process care direct resist neoliberalis healthcar engag slow practic care patient bodi mind final key hospic gaze manag space care ensur alway alreadi appear slow patient therefor hospic gaze ensur distribut power knowledg minimis corros qualiti busy maximis ethic potenti slow conclud argu oper hospic gaze examin set palliat care practic patient home care servic | D017051;D006738 | T058;T093;T073 |
34,662,762 | role trust health seek non communic diseas servic fragil context cross countri compar studi non communic diseas ncds disproportion affect peopl live fragil context mark poor govern health system struggl deliv qualiti servic benefit combin lead eros trust health system affect health seek behaviour abil individu sustain health cross countri multipl case studi analys role trust health seek ncd servic fragil context analysi triangul multipl data sourc includ semi structur interview n group model build workshop n individu affect ncds health provid deliv ncd servic data collect freetown makeni sierra leon beirut beqaa lebanon morazn chalatenango bajo lempa el salvador april april present conceptu model depict key dynam feedback loop contextu factor institut interperson social trust health seek pathway find signal first way health servic deliv experienc shape institut trust health system interperson trust health provid futur health seek pathway second histor narrat public institut state author respons contextu fragil driver impact institut trust utilis servic public health institut third social trust mediat health seek behaviour social bond link health system individu affect ncds given repeat sustain utilis health servic requir chronic diseas build maintain trust public health institut provid crucial task fragil context requir intervent communiti district nation level key focus promot link mutual account health system communiti affect ncds | D000073296 | T047 |
34,662,761 | seek recognit carcer health care bureaucraci analysi medic care request form counti jail peopl experienc incarcer us constitut right access health care yet actual right constrain everyday realiti environ design punish limit autonomi princip mean access health care carcer facil individu submit written request get handl jail bureaucrat process paper provid quantit qualit analys content circul one month written request call medic care request mcr form urban us jail understand mean health health care group individu systemat margin one month jail hous individu mcrs submit code request categori medic amelior live condit specif symptom request specif health care servic common request pain medic qualit analysi four key theme emerg relianc clinic mediat need daili life deserving health care hyperawar bodili psychic discomfort tempor techniqu assert control individu time bodi jail show mcrs key mechan incarcer individu seek recognit physic psychic suffer broad exist consid broader context control carcer regim health inequ character us societi mcrs becom dynam terrain jail health care provid incarcer peopl negoti tension deserving care | D000081702;D011329 | T098;T073 |
34,662,760 | embodi water insecur injuri chronic stress lowland bolivia water critic health wellb studi theoriz problem water becom embodi yet studi quantifi therefor first sought understand lowland bolivian water environ tsiman forag horticulturalist assess water environ holist use object measur water qualiti water servic joint monitor programm drink water servic ladder subject measur includ perceiv water safeti water insecur experi household water insecur experi scale hwise test water servic level perceiv water safeti water fetch frequenc associ hwise score use tobit regress model among household test water becom embodi via self report water relat injuri chronic stress biomark hair cortisol concentr hcc result demonstr compar household use surfac water household basic water servic hwise score pts lower se p ingest water perceiv bad daili water fetch trip associ higher hwise score twenti percent household report prior water relat injuri women common injur logist regress point higher hwise score associ ci p higher odd injuri basic water servic compar surfac water associ lower odd ci p injuri final use linear regress among adult hwise score associ hcc past water relat injuri associ higher hcc beta se p among women men reli unimprov water servic compar surfac associ higher hcc women beta se p higher hcc men beta se p respect overal find demonstr water insecur becom embodi water relat injuri elev hcc improv water servic level equiti len may help amelior water insecur accompani negat health effect | D000085222;D060753 | T070;T033 |
34,662,759 | conspiratori think select exposur conserv media respons covid us previous research shown earli month covid pandem us user conserv media like accept conspiraci theori pandem less like accept pandem mitig measur mask wear vaccin | D000086382 | T047;T067 |
34,662,758 | morpholog mechan properti lower limb competit racewalk associ perform racewalk unconvent form competit gait elicit uniqu load profil lower limb muscl tendon studi map structur mechan properti lower limb competit racewalk made associ world athlet competit perform point fourteen intern racewalk seven men seven women recruit studi static ultrasonographi use quantifi muscl tendon morpholog characterist isokinet dynamomet use measur passiv musculotendin stiff tricep sura isometr seven kneeankl angl combin isokinet four angular veloc strength paramet plantarflexor dorsiflexor isokinet knee flexion extens strength five angular veloc correl found perform fascicl length gastrocnemius mediali r p dorsiflexor strength r p knee flexor strength r p associ found isometr plantarflexion passiv stiff properti overal studi show various morpholog mechan properti associ perform competit racewalk associ seem relat specif uniqu biomechan characterist racewalk | D018482;D013710 | T023;T024 |
34,662,757 | evolut compress mechan properti earli hypertroph scar laser treatment laser therapi wide use treatment hypertroph scar hps whether mechan properti hps tissu laser treatment restor normal skin remain unclear paper relationship evolut compress mechan properti histolog chang hps tissu follow three success combin puls dye laser pdl fraction co laser co treatment investig compress test histolog analysi earli hps model rabbit ear establish co laser ablat load unload test strain creep test compress forc n n n carri normal skin untreat hps hps differ treatment time respect result show compress ratio tissu reveal forc depend rose increas compress forc similar trend biolog soft tissu histolog chang hpss follow laser treatment signific influenc compress mechan respons compar normal skin tough anti deform abil hps reduc due prolifer collagen fiber destruct elast fiber result higher energi dissip compress ratio stabl creep rate lower elast modulus three success combin pdl co laser treatment compress mechan properti creep properti hps gradual approach normal skin owe gradual restor amount distribut collagen elast fiber hps result provid new method evalu clinic efficaci laser therapi treatment hps tissu | D017439;D054025;D054020;D028022 | T061;T074;T073;T020 |
34,662,756 | simpl indent techniqu identifi local liquefact vitreous bodi identif vitreous liquefact vl import investig eye patholog relat chang mechan properti vitreous posterior vitreous detach retin detach howev extrem high water content character structur mechan properti vitreous remain challeng current studi simpl indent test perform fresh vitreous partial liquefi vitreous water use mechan test machin high precis load cell pressur load indent chang time differ sampl obtain character mechan properti vl identif achiev base comparison relat differ typic mechan paramet eg pressur moment insert p pressur steadi mechan state p time pressur indent declin one half initi valu partial liquefi vitreous fresh vitreous sampl partial liquefi vitreous water sampl result indic p partial liquefi vitreous almost half fresh vitreous p approxim time water p partial liquefi vitreous approxim time higher fresh vitreous p approxim water p conclud p use indic identifi local liquefact vitreous | D014822 | T023 |
34,662,755 | reduc midbrain function connect recoveri abstin heroin user dopaminerg pathway midbrain striatum well cortex involv addict howev altern pathway whether recoveri aberr circuit would detect prolong abstin heroin user rare known rest state function connect rsfc pattern midbrain ie ventral tegment area vta substantia nigra sn compar abstin heroin user opioid use disord hus healthi control hcs test function recoveri hypothesi cross section longitudin design cross section design hus separ short term abstain sts day long term abstain lts day regard longitudin design subject among hus follow month sandwich estim method use analyz differ baselin hus follow hus hus show lower rsfc midbrain sever cortic area medial orbitofront cortex mofc anterior cingul cortex compar hcs besid lower rsfc vta right nucleus accumben circuit well right sn caudat circuit also found hus enhanc rsfc valu vta left mofc circuit observ lts compar sts addit longitudin design also reveal increas rsfc valu midbrain frontal cortex month prolong abstin reveal abnorm function organ midbrain striato midbrain cortic circuit hus import partial recoveri dysfunct found long term abstin | D006556 | T048 |
34,662,752 | self report bodi silhouett diagnost instrument anthropometr paramet routin bodi size measur anthropometr valu requir profession standard techniqu calibr tool therefor need easier screen tool self report bodi silhouett self bosi aim studi analyz perform self bosi proxi anthropometr valu | D015331 | T062;T081 |
34,662,751 | understand mrsa clonal competit within uk hospit possibl import densiti depend methicillin resist staphylococcus aureus mrsa bacteria caus serious often healthcar associ infect frequent high resist divers antibiot multipl mrsa clonal complex ccs evolv independ countri differ preval ccs unclear domin cc region may switch | D055624;D013203 | T007;T047 |
34,662,750 | effect broadband nois learn dynam decis make cognit workload sex moder effect aim research examin broadband nois present mani workplac affect dynam decis make effect potenti moder factor cognit workload sex also examin forti eight particip femal averag age year sd ask complet dynam decis make task three consecut day independ variabl nois broadband dba vs dba background cognit workload low vs high manipul via presenc secondari task among femal broadband nois signific impair perform low workload signific improv perform high workload contrast among male broadband nois signific effect overal perform appli perspect understand interact nois cognit workload sex allow design train environ ensur maximum perform staff | D009622;D016526 | T081;T069;T067 |
34,662,749 | smaller bodi armour improv thoracolumbar rang motion reduc interfer femal soldier perform dynam task femal soldier report servic bodi armour system larg investig whether smaller prototyp bodi armour system could improv thoracolumbar rang motion rom reduc interfer femal soldier perform dynam postur femal soldier complet three rom task seven dynam postur wear armour servic bodi armour system smaller prototyp system feedback comfort prototyp system also obtain thoracolumbar rom dynam postur complet hinder use bodi armour although particip perform signific less imped wore smaller prototyp system compar servic system smaller bodi armour system better match anthropometr dimens femal soldier appear improv overal fit function increas rang bodi armour size femal specif design systemat explor enhanc fit function bodi armour | D008889 | T097 |
34,662,748 | design synthesi biolog evalu bisindol deriv anticanc agent tousl like kinas studi present design synthesi character bisindol molecul anti cancer agent tousl like kinas tlks show compound compos indirubin oxim group link n methylpiperidin yl ethyl moieti possess inhibitori activ toward tlk tlk vitro diminish phosphoryl level downstream substrat anti silenc function asf replic cell treatment compound impair dna replic slow phase progress trigger dna damag respons replic cell structur optim discov six deriv exhibit potent tlk inhibitori activ reveal import tertiari amin contain moieti side chain moreov deriv strong suppress growth tripl negat breast cancer mda mb cell non small cell lung cancer cell colorect cancer hct cell normal lung fibroblast mrc imr cell show lower respons compound taken togeth studi identifi tertiari amin link indirubin oxim potent anticanc agent inhibit tlk activ | D015195 | T090 |
34,662,746 | dna methyl gene associ evolut age diseas critic review age characteris physic declin biolog function result progress risk mortal time biolog phenomenon underpin dysregul myriad complex process recent howev ever increas evid associ epigenet mechan dna methyl dnam age onset patholog includ cancer cardiovascular diseas alzheim diseas diseas compromis healthspan consequ medic imper understand link epigenet age healthspan evolutionari theori provid uniqu way gain new insight epigenet age health review provid brief overview main evolutionari theori age discuss recent genet evid reveal allel pleiotrop effect fit differ age human consid effect dnam pleiotrop allel associ age relat diseas discuss age relat dnam chang reson mutat accumul dispos soma program theori age discuss dnam chang associ calor restrict intersect evolut age conclud discuss evolutionari theori use inform investig quantifi age relat dnam chang link age onset patholog | D000375;D019175 | T040;T033;T044 |
34,662,745 | inflammag cannabinoid age complex phenomenon associ wide spectrum physic physiolog chang affect everi part metazoan escap death prior reach matur critic surviv immun system evolv princip compon respons injuri defens pathogen invas signific immun system affect affect age sever neolog appear encapsul reciproc relationship immunosenesc central part immunosenesc inflammag sustain low grade steril inflamm occur reach reproduct prime initi impact inflammag advers effect determin direct magnitud inflammag articl review natur vicious cycl propos phytocannabinoid immun regul may possess potenti effect adjunct therapi slow certain case revers patholog senesc permit healthi age | D002186;D000068884 | T039;T121;T109 |
34,662,744 | preval unwilling uncertainti vaccin covid older peopl systemat review meta analysi coronavirus diseas covid shown sever health outcom older peopl specif relat mortal disabl vaccin seem efficaci safe prevent negat consequ covid vaccin hesit seem high older adult therefor aim investig preval unwilling uncertainti vaccin covid older peopl factor associ unwilling vaccin work search sever databas th june studi report preval unwilling uncertainti vaccin covid peopl age year meta analysi preval correspond confid interv cis propos factor associ unwilling vaccin covid explor multivari analys report odd ratio or among paper initi screen includ studi total older adult preval unwilling vaccin covid older peopl ci whilst correspond figur uncertainti ci risk unvaccin signific higher hispan ci case low educ ci low incom ci conclus hesit covid vaccin relev problem older peopl particular low incom low level educ hispan live unit state | D000086382;D000086663 | T047;T200;T067 |
34,662,743 | character emerg high risk kpc produc klebsiella pneumonia lineag caus fatal wound infect spine surgeri surgic site infect instrument posterior lumbar interbodi fusion surgeri normal due gram posit bacteria gram negat bacteria caus infect case involv lower lumbar intervent closer perian area report uncommon fatal wound infect caus multidrug resist klebsiella pneumonia elect spine surgeri silico analysi reveal lwist belong st emerg intern clone notabl increas virul potenti also observ strain carri conjug incf plasmid encod resist gene beta lactam bla kpc bla oxa tetracyclin teta aminoglycosid fluoroquinolon aac ib cr carbapenemas encod gene bla kpc locat tne transposon previous character increas bla kpc express lwist strong biofilm produc polystyren capabl form tower like structur titanium devic like one insert patient spine find strengthen valuabl contribut continu surveil multidrug resist high risk k pneumonia clone avoid unfavour clinic outcom | D024901 | T032 |
34,662,740 | leukotrien inhibit risk lung cancer among us veteran asthma leukotrien inhibit vitro vivo found suppress tumor growth across varieti cancer cell mous model lung cancer reveal leukotrien inhibitor montelukast induc lung cancer cell death base preclin data hypothes exposur leukotrien inhibitor associ lower risk lung cancer conduct nation retrospect cohort studi among us veteran asthma explor relationship leukotrien inhibit incid lung cancer util varieti statist techniqu includ cox proport hazard model propens score match falsif test examin associ total patient met studi criteria consist patient leukotrien exposur patient leukotrien medic use leukotrien inhibitor exposur reduc risk lung cancer hr ci unmatch match analysi hr ci falsif test append rotat cuff injuri end point suggest evid select bias howev treatment random residu confound rule pre clinic data leukotrien inhibit lung cancer combin databas analysi provid intrigu evid warrant research relationship leukotrien lung cancer | D001249;D008175;D011804;D014728 | T098;T191;T047;T109 |
34,662,739 | integr taguchi method artifici neural network predict maxim biofuel product via torrefact pyrolysi artifici neural network ann one kind artifici intellig comput system aim process inform way neuron human brain studi combin taguchi method ann use maxim predict biofuel yield spent mushroom substrat torrefact pyrolysi via microwav irradi taguchi method util design multipl factor particl size catalyst power magnet agent level experi paramet highest total biofuel yield biochar bio oil accomplish combin particl size mgg sms catalyst w power mgg sms magnet agent ann one hidden layer show outstand linear regress predict highest biofuel yield biochar bio oil high linear regress indic ann quick propag algorithm appropri approach predict biofuel convers | D056804;D000077319 | T070;T109 |
34,662,738 | recent advanc membran biofilm reactor micropollut remov fundament perform microbi communiti occurr micropollut mps water wastewat impos potenti risk ecolog secur human health membran biofilm reactor mbfr emerg technolog attract much attent mps remov water wastewat review aim consolid recent advanc membran biofilm reactor mps remov standpoint fundament remov perform microbi communiti first configur work principl mbfrs review prior discuss current status system thereaft comprehens review mbfr perform mps elimin base literatur databas present key inform microbi communiti great signific remov perform synthes perspect futur research need also provid review ensur develop mbfrs cost effect elimin mps water wastewat | D064307;D014874 | T131;T032;T001;T028 |
34,662,737 | review limb regener lizard natur experiment condit consider induct appendag regener amniot studi failur limb regener lizard evid difficult problem met amniot regener organ contrari tail limb loss terrestri environ general fatal select regener occur lizard evolut | D008116 | T014 |
34,662,736 | structur violenc trap dispar homicid chronic diseas death social factor across san francisco neighborhood averag person live san francisco expect live year number conceal signific variat sex race place resid examin death area base social factor san francisco neighborhood hypothes social disadvantag neighborhood shoulder disproportion mortal burden across generat especi death attribut violenc chronic diseas data inform target intervent guid research effect solut san francisco margin communiti | D006708;D000083663 | T068;T102;T054;T055 |
34,662,733 | updat use biochem biomark fish evalu alter produc pharmaceut product evalu toxic effect stress environment condit determin imbal exogen factor environment contamin enzymat non enzymat defens biolog system use fish identif alter biochem biomark provid comprehens vision effect pharmaceut product caus aquat ecosystem organ high sensit contamin filter capac potenti environment toxicolog studi wide rang pharmaceut stimul alter varieti biochem mechan oxid damag membran lipid protein chang antioxid enzym review includ summari knowledg last year understand differ biochem biomark generat exposur pharmaceut fish includ differ categori pharmaceut product nsaid analges antibiot anticonvuls antidepress hormon lipid regul mixtur review serv tool design studi evalu effect pharmaceut product take account use biomark type matrix enzym alter take pharmaceut group interest | D064420;D005399 | T013;T046;T037 |
34,662,732 | deciph toxicolog role porphyromona gingivali deriv endotoxin liver diseas periodont preval infecti multifactori inflammatori diseas character progress destruct tooth support tissu porphyromona gingivali gramneg oral anaerob main caus periodont one import risk factor respons aggrav exist system diseas sever experiment clinic studi shown posit associ periodont differ form liver diseas periodont diseas increas preval non alcohol fatti liver diseas cirrhosi infect periodontium pathogen periodont microenviron releas pathogen associ molecular pattern peptidoglycan lipopolysaccharid gingipain fimbria bacteri dna etc damag associ molecular pattern interleukin galectin etc virul factor cytokin enter bloodstream dissemin whole bodi induc varieti system patholog effect includ liver diseas steatosi fibrosi maintain oral hygien scale root plan signific improv liver damag patient periodont dentist physician awar understand bidirect natur relationship oral system diseas import periodont condit aggrav simpl fatti liver fibrot diseas therefor aim review understand possibl link periodont liver diseas | D016966 | T007 |
34,662,730 | electrochem character mutant form rubredoxin b mycobacterium tuberculosi electron transfer metalloprotein drive forc mani biolog process wide distribut natur rubredoxin b rubb mycobacterium tuberculosi first exampl among fe protein support catalyt activ termin sterol monooxygenas enabl applic metabol engin explor toler rubb specif amino acid chang evalu effect surfac mutat electrochem properti base rubb fold also design mutant putat addit site protein protein interact evalu electron transfer electrochem properti investig redox properti mutant variant rubb done use screen print graphit electrod spes modifi stabl dispers multi wall carbon nanotub mwcnts redox potenti midpoint potenti e mutant signific differ wild type protein vari rang mv vs agagcl electrod howev mutat affect electron transfer rate protein electrod notabl modul protein protein interact observ insert mutant suggest possibl tailor rubredoxin select redox partner overal rubb toler signific modif structur enabl ration engin novel redox protein | D009154 | T045 |
34,662,729 | effect chitin daphnia simili deriv chitosan immun respons diseas resist white shrimp litopenaeus vannamei daphnia simili chitin deriv chitosan prepar immunostimul boost immun respons determin abil control infecti diseas caus vibrio alginolyticus white shrimp litopenaeus vannamei three experiment diet supplement chitin chitosan control chitin chitosan fed shrimp day dietari inclus chitosan acceler shrimp growth compar chitin control surviv diseas resist shrimp increas signific fed chitin chitosan diet pathogen inject indic regul immun respons respiratori burst rb superoxid dismutas sod phagocyt activ pa signific differ total haemocyt count thc phenoloxidas po activ lysozym lyz activ among group signific differ observ prophenoloxidas system relat gene express among group howev shrimp fed chitin chitosan express signific higher level antimicrobi protein penaeidin crustin anti lipopolysaccharid factor haemocyt control gene express catalas heat shock protein increas hepatopancrea shrimp fed chitosan diet compar chitin control diet link n acetylglucosamin transferas ogt signific higher haemocyt shrimp fed chitosan chitin control ogt signific higher hepatopancrea shrimp fed chitosan dietari chitin chitosan also show posit effect transcript peritrophin like protein find suggest chitin chitosan simili efficaci boost immun shrimp prevent control infecti diseas caus vibrio great potenti use feasibl immunostimul signific contribut circular economi | D048271;D033561 | T204;T121;T109 |
34,662,728 | high carbohydr diet induc endoplasm reticulum stress oxid stress promot inflamm apoptosi impair intestin barrier juvenil largemouth bass micropterus salmoid studi assess effect feed carbohydr content intestin physic barrier immun juvenil largemouth bass micropterus salmoid triplic group juvenil fish g fed low lcd medium mcd high hcd carbohydr diet eight week gut histolog reveal slight infiltr inflammatori cell moder loss mucous membran layer hcd group express zo occlud claudin gene epiderm growth factor receptor egfr gene signific decreas hcd group indic impair tight junction epitheli cell regener result show signific p reduct antioxid capac hcd group compar lcd furthermor express intestin er relat gene ire eif grp chop chop hcd group signific higher lcd group addit hcd induc regul express inflammatori il il tnf cox apoptosi traf bax casepas caspas casepas relat gene fish intestin data generat studi clear demonstr hcd induc er oxid stress promot intestin inflamm apoptosi juvenil largemouth bass | D001492 | T013 |
34,662,727 | time die depth analysi jame bond exposur infecti agent global travel whether tourist secret agent expos smrgsbord infecti agent hypothes agent pre occupi espionag counterterror may peril fail correct priorit travel medicin examin hypothesi examin adher intern travel advic intern journey jame bond observ undertak featur film span scrutin mission involv min even hour per author could easili spent press societ issu uncov averag sexual activ often without suffici time exchang sexual histori remark high mortal among bond sexual partner confid interv given inopportun bout diarrhea would midst world save action strike bond seen wash hand two occas despit numer exposur foodborn pathogen hypothes foolhardi courag sometim purpos elicit life threaten situat might even consequ toxoplasmosi bond approach vector born diseas neglect tropic diseas errat sometim follow travel advic letter often dwell side complet ignor given limit time bond receiv prepar mission urgent ask employ mi take respons serious live | D014195;D057236 | T091;T052;T056 |
34,662,726 | platelet mediat tumor metastasi mechan role cell adhes molecul mount evid suggest platelet play essenti role cancer metastasi interact platelet circul tumor cell ctcs promot cancer metastasi ctcs induc platelet activ aggreg activ platelet gather protect ctcs shear stress natur killer cell final platelet stimul ctc anoiki resist epitheli mesenchym transit angiogenesi extravas eventu metastasi cell adhes molecul cam identifi activ player interact ctcs platelet specif mechan under contribut platelet associ cam ctc metastasi remain unclear review introduc mechan platelet relat tumor metastasi particular focus role cam | D001792;D009360 | T025;T191 |
34,662,725 | framework anti racist public palliat care structur process outcom system structur racism describ embed pattern explicit implicit racial bias polici action systemat confer advantag white peopl disadvantag black indigen peopl color hospic palliat care journal particip broader system racial discrimin build palliat care explicit focus patient goal valu may compris form social justic healthcar palliat care journal publish opportun lead other cultiv anti racist practic explicit promot equiti public life cycl submiss solicit manuscript peer review public provid framework examin structur process outcom palliat care journal might address system racism describ current academ publish landscap diminish voic experi racial ethnic minor patient undermin career repres scholar propos reform believ improv public equiti qualiti well healthcar outcom includ equiti public checklist solicit manuscript equiti relev topic promot scholar editori structur peer review process standard equiti rate public greater effort includ non domin voic everi aspect public appropri recognit scholarship remuner effort drive equiti health outcom pursu anti racist equiti focus publish agenda hospic palliat medicin journal publish opportun transform healthcar | D010166;D063505 | T054;T061 |
34,662,724 | success communiti base deliveri recruit individu underserv communiti observ cohort studi advanc care plan intervent underserv minor popul often reluct engag advanc care plan andor research often due distrust healthcar andor research institut | D032722 | T058 |
34,662,723 | beyond advanc direct address communic gap caregiv challeng life end premis advanc direct care plan help peopl articul document wish surrog decis maker provid honor howev beyond complet document under challeng often unaddress object overal purpos studi investig communic includ limit complet advanc direct caregiv influenc famili caregiv experi communic gap caregiv challeng unaddress advanc direct present | D032722;D013727 | T058 |
34,662,722 | compar valid most unprocess minim process food item differ among popular commerci nutrit app compar research food databas commerci nutrit app increas use evalu diet evalu compar valid nutrient data commerci nutrit app databas import determin merit use app dietari assess | D063731 | T170 |
34,662,720 | social predict pediatr patient congenit non progress malform cerebellum deficit predict movement rehabilit virtual realiti propos impair predict function exert cerebellum may account social cognit deficit integr cerebellar function predict code framework elucid congenit non progress cerebellar alter could affect predict process other behavior experi demonstr cerebellar patient impair reli contextu inform predict person movement impair signific associ social cognit abil experi indic children adolesc congenit non progress cerebellar malform show domain general deficit use contextu inform predict other movement physic event impair independ patient cognit abil experi provid first evid social predict train virtual realiti could boost abil use context base predict understand other intent find shed new light predict role cerebellum contribut social cognit pave way new approach rehabilit cerebellar cognit affect syndrom | D002526;D000076142 | T047;T066 |
34,662,719 | qualiti design tool reduc gap bench bedsid nanomedicin pharmaceut nanotechnolog research focus smart nano vehicl deliv activ pharmaceut ingredi enhanc efficaci rout administr vari therapeut applic design develop new nanopharmaceut labori recent year applic mathemat statist comput tool emerg conveni strategi purpos applic qualiti design qbd tool introduc guarante qualiti pharmaceut product improv translat research laboratori bench applic therapeut review collect basic concept histor overview applic qbd nanomedicin discuss specif focus put respons surfac methodolog artifici neural network approach general term applic develop nanomedicin monitor process paramet obtain optim system ensur qualiti profil | D036103;D014677;D013678 | T091;T120;T090 |
34,662,718 | suprachoroid deliveri bevacizumab rabbit vivo eye rapid distribut throughout posterior segment test vivo bio distribut safeti bevacizumab deliveri suprachoroid space scs use novel inject system larg eye model | D000068258;D000080324;D012160 | T116;T047;T121;T023;T129;T020;T030 |
34,662,717 | genom mine biosynthet gene cluster intend secondari metabolit conserv actinobacteria evolut genom sequenc technolog one hand advanc comput genom mine tool hand pave way improv predict secondari metabolit past numer effort made concern genom mine recogn secondari metabolit within genus neglig quantiti compar genom report carri among speci differ genera studi explor potenti actinobacteria speci belong genera includ streptomyc nocardia micromonospora saccharomonospora travers divers distribut biosynthet gene cluster bgcs investig result obtain antismash antibiot secondari metabolit analysi shell napdo natur product domain seeker npsearcher reveal conserv genus specif gene cluster among various speci eg naggn n acetyl glutaminyl glutamin amid present micromonospora furan nocardia melanin lassopeptid occur streptomyc bioactiv compound like alkyl dihydro geranyl methoxi hydroquinon sapb desferrioxamin e methylisoborneol mayamycin cyclodipeptid synthas diisonitril salinichelin hopen ectoin isorenieraten high conserv among divers genera furthermor pharmacolog activ actinobacteri deriv metabolit bacteri fungal pathogen illustr need accomplish larg scale analysi natur product includ various genera actinobacteria deliv comprehens intuit overcom antibiot resist | D039903;D013302 | T007 |
34,662,716 | impact sex suscept system lupus erythematosus rheumatoid arthriti bioinformat point view unknown etiolog system autoimmun diseas system lupus erythematosus sle rheumatoid arthriti ra remark predomin femal prompt mani research unveil precis molecular mechan involv gender bias fact depend hormon transcrib gene sex chromosom least initi mechan involv pathogenesi might differ larg aim elucid mechan tri specifi differenti express gene deg extract microarray librari femal male sle ra patient subsequ androgen estrogen receptor element ere among differenti express transcript factor tfs deg locat x chromosom determin moreov pathway regard common deg sex enrich data reveal sever ere contain gene lcn ltf rpl rpl rps rps rpsl sa abca histhbd isg mafb gnli evl hdc associ relat autoimmun diseas sex also two deg kdmd rpsi sle patient determin chromosom one prove associ autoantigen sle altogeth data show number plausibl pathway autoimmun condit togeth relev sever sex relat gene mention diseas pathogenesi | D001172;D008180 | T047 |
34,662,715 | high low ioniz radiat effect protein synthesi ioniz radiat ir constant featur environ one dramat affect organism health develop although impact high dose ir mammalian cell system broad explor still challeng accur quantifi biolog respons ir especi low dose rang individu expos lifetim result uncertainti led entrench conserv radioprotect polici around world thus uncov long sought molecular mechan tissu respons target ir could lead inform policymak propos new therapeut avenu varieti patholog one often overlook target ir mrna translat high regul cellular process consum cell energi respons environment stimuli regul mrna translat allow precis rapid chang cellular proteom unsurpris high dose ir shown trigger sever reprogram global protein synthesi allow cell conserv energi prevent synthesi unneed protein nonetheless condit certain mrnas encod specif protein translate favour produc factor essenti repair cell send path return program cell death understand mechan control protein synthesi respons vari dose ir could provid novel insight stress mediat cellular adapt regul potenti uncov novel target radiosensit radioprotect review current literatur effect ir high low dose mrna translat machineri | D014176;D011839 | T044;T070 |
34,662,712 | prl dephosphoryl p mapk promot cell surviv stress hypoxia within tumor microenviron lead excess ros genom instabl one hallmark cancer contribut self renew capabl metastasi radio chemotherapi resist prl oncoprotein involv various pro surviv signal pathway raserk pikakt srcstat mtorc jakstat howev littl evid connect prl mediat apoptosi resist tumor microenvironment stress studi profil prl express multipl tumor type retriev public databas tcga ncbi geo confirm oncogen function prl found intrigu connect prl express tumor hypoxia signatur gene moreov use cocl hypoxia mimet ros induc discov cell stabli express prl catalyt inact mutant prl cs show signific resist cocl induc apoptosi resist apoptosi found depend p mapk signal confirm condit microenvironment stress includ uv h hypoxia mechanist prove prl direct phosphatas p mapk stress condit addit mous model tumor metastasi higher lung metastat burden lower p mapk phosphoryl found mice seed gfp prl express cell compar seed gfp ctrl cell taken togeth studi identifi critic role rpl tumorigenesi negat regul p mapk activ order facilit tumor cell adapt hypox stress tumor microenviron suggest prl could serv promis novel therapeut target cancer patient | D002470;D048051 | T043;T116;T126 |
34,662,711 | mincr long non code rna share cancer neurodegener multitask natur lncrnas allow play central role physiolog patholog condit often lncrna particip differ diseas specif myc induc long non code rna mincr upregul various cancer type downregul amyotroph later sclerosi patient therefor work aim investig mincr potenti mechan action implic cancer neurodegener relat express level sh syy cell rna sequenc approach result show mincr overexpress caus massiv alter cancer relat gene lead disrupt mani fundament process cell cycl growth factor signal contrari mincr downregul influenc small number gene involv differ neurodegen disord most concern rna metabol inflamm thus understand caus function consequ mincr deregul give import insight potenti pathogenet mechan cancer neurodegener | D009369;D062085 | T191;T114;T123 |
34,662,710 | evid base social scienc china paper qualiti social scienc systemat review meta analysi publish examin characterist methodolog report qualiti systemat review meta analys social scienc journal china | D057189;D012942 | T170;T090 |
34,662,709 | pain medic belief mediat relationship pain catastroph opioid prescript use patient chronic non cancer pain littl known mechan pain catastroph may associ opioid use outcom studi aim investig potenti mediat role belief appropri pain medicin pain treatment associ pain catastroph prescript opioid use communiti chronic non cancer pain cncp sampl individu n diagnos cncp particip cross section onlin self report studi valid measur pain medic belief pain catastroph current prescript opioid use two parallel multipl mediat analys percentil base bootstrap examin pathway prescript opioid use high dose use mg oral morphin equivalentsday control pain intens relev covari pain medic belief signific mediat associ pain catastroph prescript opioid use ci similar pattern find found high dose opioid use pain medic belief signific mediat pain catastroph high dose use associ ci pain medic belief potenti modifi psycholog mechan pain catastroph associ opioid use includ high dose use find import implic person prevent treatment program | D059350;D009293 | T048;T047;T184 |
34,662,708 | ungap best practic improv solubl data qualiti oral administ drug import goal european cooper scienc technolog cost action ungap understand gastrointestin absorpt relat process wwwungapeu improv standard method relat studi oral drug absorpt solubl general term refer maximum achiev concentr compound dissolv liquid medium oral administ drug relev inform drug properti crucial drug product develop regulatori level collect reliabl reproduc solubl data requir care applic understand limit select experiment method addit puriti compound solid state form well experiment paramet temperatur experiment media relat factor sampl handl procedur affect data qualiti paper intern consensus develop cost ungap network recommend collect high qualiti solubl data develop oral administ drug propos | D000068598;D004364 | T080;T121 |
34,662,706 | discoveri novel triazol compound select il releas inhibitor inflamm immun close relat occurr develop varieti immun diseas although il identifi key cytokin mani immun diseas safe specif small molecular il releas inhibitor still scarc urgent requir clinic investig prospect triazolei limit complic pharmacolog effect exhibit inferior effect il tnf herein novel deriv design synthes near half deriv exhibit much better select il releas inhibit well keep similar inhibitori activ lead compound compound exhibit il releas inhibitori activ ic close origin compound fold superior select si lead compound si probabl sar model triazol deriv il releas inhibit select also propos might promot discoveri effect specif il releas inhibitor futur | D055808 | T062 |
34,662,703 | axon diamet infer human corpus callosum use oscil gradient spin echo sequenc previous method use infer axon diamet distribut use magnet reson imag mri primarili use singl diffus encod sequenc puls gradient spin echo pgse thus sensit axon diamet appli oscil gradient spin echo ogs sequenc studi human axon rang corpus callosum includ major axon constitut cortic connect activeax model appli calcul fit mean effect diamet axon axd compar valu found use histolog axon diamet histolog data calcul use three differ dataset true diamet minimum diamet combin minimum maximum diamet diamet measur across consist diffus direct axd estim mri averag activeax model histolog axd valu use true minimum axon diamet use combin minimum maximum axon diamet collect measur across consist diffus direct experi demonstr first known usag ogs calcul axon diamet human corpus callosum scale import model account axon orient dispers indic histolog result close match mri model result depend direct axon diamet measur initi step use non invas imag method appli futur methodolog develop vivo axon diamet measur human brain tissu | D003337;D038524 | T023;T060 |
34,662,702 | free breath stack radial mri quantif liver fat r adult fatti liver diseas investig agreement intra session repeat inter reader agreement liver proton densiti fat fraction pdff r quantif use free breath stack radial mri without self gate motion compens compar refer breath hold techniqu subject fatti liver diseas fld | D008279;D065626 | T047;T170;T059;T060 |
34,662,701 | detect intramur fat accumul dixon caipirinha vibe contribut techniqu determin chronic chron diseas studi aim evalu efficaci dixon caipirinha vibe fat imag detect intramur fat accumul ifa contribut dixon caipirinha vibe manag patient chron diseas | D007089;D007090 | T062;T066;T060 |
34,662,700 | predict valu dki breast cancer tumour subtyp affect patholog respons evalu explor differ quantit paramet base diffus weight imag dwi diffus kurtosi imag dki differ immunohistochem indic status predict valu neoadjuv chemotherapi nac among differ phenotyp breast cancer | D001943 | T191 |
34,662,699 | automat quantif white matter hyperintens weight fluid attenu invers recoveri magnet reson imag white matter hyperintens wmh area increas signal visual weight fluid attenu invers recoveri flair brain magnet reson imag mri sequenc typic attribut small vessel cerebrovascular diseas context age among older adult wmh associ risk cognit declin dementia stroke various health outcom increas interest incorpor quantit wmh measur outcom clinic trial observ research clinic set present novel fulli autom unsupervis detect algorithm wmh segment quantif algorithm use robust preprocess pipelin includ brain extract sampl specif mask incorpor spatial inform automat fals posit reduct half gaussian mixtur model hgmm method evalu particip vari degre wmh cm communiti base studi age dementia dice coeffici sensit specif correl bias relat ground truth manual segment approach perform two expert rater result compar deriv common use avail wmh segment packag includ spm lesion probabl algorithm lpa spm lesion grow algorithm lga brain intens abnorm classif algorithm bianca hgmm algorithm deriv wmh valu dice score sensit specif compar ground truth white matter hyperintens volum deriv hgmm strong correl ground truth valu r p e observ bias p valu novel algorithm uniqu use robust preprocess pipelin half gaussian mixtur model segment wmh high agreement ground truth larg scale studi brain age | D049292;D020521;D066127 | T047;T023;T046;T024 |
34,662,697 | detect pericardi flow black blood prepar hast sequenc imag differenti pericardi diverticulum cyst pericardi diverticulum focal herniat pericardium differenti pericardi cyst presenc communic pericardi caviti radiolog differenti diverticulum cyst via comput tomographi difficult unless chang size identifi differ bodi posit addit scan herein describ case pericardi diverticulum success diagnos via detect intern pericardi flow black blood prepar half fourier acquisit singl shot turbo spin echo magnet reson imag detect flow void pericardi sac may definit magnet reson imag find diagnosi pericardi diverticulum | D003560;D004240 | T190;T047 |
34,662,695 | effect hyperbar oxygen therapi tomati sound therapi children autism spectrum disord mani therapeut dietari regimen studi children autism spectrum disord asd last three decad aim evalu efficaci hyperbar oxygen therapi hbot tomati sound therapi tst egyptian cohort children asd studi prospect open label random intervent clinic trial one hundr forti six children asd previous rehabilit therapi enrol studi patient random divid four group first group receiv hyperbar oxygen therapi second group receiv tomati sound therapi third group receiv combin modal fourth group control group receiv intervent found combin tomati sound therapi hyperbar oxygen therapi superior effect improv autism symptom intervent alon car therapi versus intervent p combin modal may help children asd distinct evid support use combin therapi asd still controversi howev studi provid evid benefit combin therapi children asd futur studi use sophist research design begin find consist baselin measur use evalu effect therapi asd | D006931;D009147;D011615 | T061 |
34,662,693 | cannabidiol impair reward effect methamphetamin involv dopaminerg receptor nucleus accumben cannabidiol compon cannabi potenti hinder reward impact drug abus howev mechan ambigu moreov nucleus accumben nac key area reward circuit extens receiv dopaminerg project ventral tegmentum area elucid role accumb dopamin receptor famili cannabidiol inhibitori impact acquisit express phase methamphetamin met condit place prefer cpp procedur common method assay reward characterist drug carri six group rat treat various dose sch sulpirid g l nac dopamin receptor famili antagonist respect prior infus cannabidiol g l later ventricl lv condit phase acquisit experi second step studi anim receiv sch sulpirid nac cannabidiol g l infus lv express phase met illumin influenc sch sulpirid inhibitori impact cannabidiol express met induc cpp intra nac administr either sch sulpirid impair cannabidiol suppress impact express phase sulpirid could suppress cannabidiol impact acquisit phase met induc cpp also inhibitori impact sulpirid stranger phase met reward seem cannabidiol prevent express acquisit phase met induc cpp part dopaminerg system nac | D002185;D003214;D012201 | T121;T041;T109 |
34,662,692 | micronutri athlet perform review optimis nutrit intak key compon support athlet perform support adapt train athlet often use micronutri supplement order correct vitamin miner defici improv immun function enhanc recoveri optimis perform aim review investig recent literatur regard micronutri specif iron vitamin c vitamin e vitamin calcium effect physic perform past ten year sever studi investig impact micronutri aspect athlet perform sever review aim provid overview current use effect current balanc literatur suggest micronutri supplement well nourish athlet enhanc physic perform excess intak dietari supplement may impair bodi physiolog respons exercis support adapt train stress case micronutri supplement warrant exampl diagnos defici energi intak compromis train compet altitud howev micronutri prescrib medic profession athlet encourag obtain adequ micronutri wellbalanc vari dietari intak | D054874;D009752;D013177;D064133 | T040;T033;T056;T055 |
34,662,690 | treatment effect percutan coronari intervent dialysi patient st elev myocardi infarct patient receiv mainten dialysi higher mortal primari percutan coronari intervent ppci patient receiv dialysi whether ppci confer benefit patient receiv dialysi similar occur lower risk group remain unknown compar effect ppci hospit outcom among patient hospit st elev myocardi infarct stemi receiv mainten dialysi effect among patient hospit stemi receiv dialysi | D062645;D000072657 | T047;T061 |
34,662,689 | one hour post load hyperglycemia combin hbac identifi individu augment duoden level sodiumglucos co transport individu hbac defin prediabet hbac hour post load plasma glucos hpg mgdl increas risk develop type diabet tdm tdm associ higher intestin express sodiumglucos co transport sglt glucos transport glut current unsettl whether hbac defin dysglycem condit combin hpg mgdl associ chang sglt glut duoden abund | D003924;D006943;D011236 | T033;T047 |
34,662,688 | plasma mid region pro atrial natriuret peptid predict cardiovascular event patient type diabet independ subclin organ damag aim studi investig associ plasma mr proanp cardiovascular diseas cvd middl age popul type diabet | D002318;D003924 | T047 |
34,662,687 | recent advanc riboflavin transport rfvt genet diseas riboflavin vitamin b essenti cellular growth function enzymat convert flavin mononucleotid fmn flavin adenin dinucleotid fad particip metabol oxid reduct reaction carbohydr amino acid lipid human riboflavin transport rfvt rfvt rfvt identifi character sinc high specif transport riboflavin rfvt function characterist differ rfvt rfvt rfvt contribut absorpt small intestin reabsorpt kidney transport fetus placenta rfvt mediat tissu distribut riboflavin blood sever mutat slca gene encod rfvt slca gene encod rfvt found patient rare neurolog disord known brown vialetto van laer syndrom patient common present bulbar palsi hear loss muscl weak respiratori symptom infanc later childhood decreas plasma riboflavin level observ sever case recent studi knockout mice patient deriv cell advanc understand mechan summar novel find rfvt genet diseas discuss potenti therapeut drug | D010244;D006319 | T047 |
34,662,686 | molecular character immun respons function activ manganes superoxid dismutas disk abalon halioti discus discus superoxid dismutas sod metalloenzym convert superoxid radic h although sod extens studi mammal speci compar studi invertebr abalon lack aim character manganes superoxid dismutas disk abalon halioti discus discus abmnsod assess transcript level differ embryon development stage addit tempor express abmnsod differ abalon tissu respons bacteri viral pathogen associ molecular pattern pamp stimuli investig sod activ measur various recombin protein concentr via xanthin oxidasewst system cell viabil upon exposur h wound heal abil subcellular local determin abmnsod transfect cell abmnsod bp long contain sod domain abmnsod express higher trochophor stage stage challeng immun stimul abmnsod show highest express h post inject pi stimul except lipopolysaccharid gill highest abmnsod express observ h pi except vibrio parahaemolyticus challeng recombin abmnsod show concentr depend xanthin oxidas activ furthermor abmnsod transfect cell surviv h induc apoptosi exhibit signific wound gap closur expect abmnsod local mitochondria cell find suggest abmnsod essenti antioxid enzym particip regul development process defens mechan oxid stress host | D049851;D014736 | T204;T007 |
34,662,684 | toll like receptor evolut lymnaeid freshwat snail speci radix auricularia lymnaea stagnali key intermedi host zoonot trematod one major evolutionarili conserv pathway innat immun invertebr toll like receptor tlr pathway howev littl known tlr protein famili gastropod mollusc despit role transmiss human diseas especi common lymnaeid freshwat snail speci radix auricularia lymnaea stagnali key intermedi host zoonot trematod use compar genom gene predict approach utilis freshwat snail biomphalaria glabrata genom refer ten putat tlr protein identifi r auricularia l stagnali phylogenet analys reveal unlik mollusc lymnaeid speci also possess class tlrs previous thought uniqu b glabrata gene duplic event also seen across tlr class lymnaeid sever gene appear exist potenti tandem element r auricularia predict tlr shown possess typic leucin rich repeat extracellular tir intracellular domain singl cystein cluster multipl cystein cluster tlrs identifi lymnaeid speci principl compon analys model predict tlrs show class protein cluster base similar structur suggest potenti adapt rang pathogen studi provid first detail account tlrs lymnaeid afford platform research role protein suscept compat snail trematod role transmiss | D008195;D014200 | T204 |
34,662,683 | tissu inhibitor metalloproteinas involv ros mediat inflamm via regul matrix metalloproteinas express sea cucumb apostichopus japonicus tissu inhibitor metalloproteinas timp serv matrix metalloproteinas mmp inhibitor pathogenesi inflammatori diseas vertebr clone characteris timp gene apostichopus japonicus use race approach design ajtimp vibrio splendidus challeng sea cucumb peak express ajtimp mrnas coelomocyt detect h fold remain high level fold h similar ajtimp express upregul primari coelomocyt expos g ml lps ajtimp express tissu highest express observ bodi wall function investig reveal imbal ratio ajmmpajtimp skin ulcer syndrom sus diseas group sharpli regul compar healthi group furthermor ajtimp knock use small interf rna sirna kd fold ajmmp ajmmp upregul fold respect ajtimp sirna kd promot ros product wherea ajmmp sirna kd elimin increas ros inflam tissu collagen iii level decreas respect ajtimp sirna group h ajtimp involv inflammatori respons mediat ros format collagen degrad | D012616;D047528;D014733 | T204;T007 |
34,662,681 | axl neuron promot jev infect dampen innat immun japanes enceph virus jev caus common diagnos viral enceph asia jev high neurotrop flavivirus replic effici brain axl belong tam tyro axl mer famili group tyrosin kinas receptor involv viral entri mick apoptot bodi regul innat immun howev under mechan regul neuron jev unclear found axl upregul neuron jev infect unexpect axl defici axl mice suscept jev infect increas viral load neuron rna sequenc analysi wild type neuron axl neuron infect jev show mani interferon stimul gene downregul axl neuron innat immun attenu larg rescu experi axl neuron indic axl may posit involv regul antivir immun taken togeth data demonstr axl may play antivir role jev replic within neuron modul neuron innat immun | D004664;D004672 | T047;T005 |
34,662,680 | era instead era mediat stimulatori effect estrogen express viral oncogen hpv ee malign phenotyp cervic cancer cell high risk human papillomavirus hpv main causat factor cervic cancer addit estrogen receptor also involv develop carcinogenesi canon estrogen receptor er frequent defici variant er high express cervic cancer cell biolog signific receptor transit er er remain unclear present studi result rt pcr western blot demonstr er er function antagonist express viral oncogen hpv e e mrna protein level er inhibit hpv ee express wherea er stimul hpv ee express overexpress er promot cell prolifer reintroduct er cervic cancer cell signific affect cell prolifer line differ effect er er express cell cycl regul name p p cyclin furthermor er suppress wherea er promot migrat invas cervic cancer cell relat opposit role er er wnt cateninmrtf signal pathway activ hpv e result studi suggest er function tumor suppressor wherea er oncoprotein cervic cancer cell er defici togeth er overexpress might enhanc express hpv ee gene facilit develop cervic cancer target er select antagonist promis strategi cervic cancer therapi | D009856;D030361;D002583 | T191;T116;T047;T123 |
34,662,679 | receptor profil immunogen non epidem norovirus gii variant norovirus causat agent acut nonbacteri gastroenter epidem worldwid various genotyp among non epidem genotyp gii caus norovirus outbreak previous demonstr immunogen gii differ epidem variant studi aim comprehens compar receptor profil immunogen gii variant epidem variant use baculovirus insect cell express system observ recombin capsid protein vp norovirus gii gz l strain form virus like particl vlps diamet approxim nm evidenc transmiss electron microscopi analysi gii vlps show weak moder bind secretor histo blood group antigen hbgas non secretor evidenc hbga vlp bind test gii vlp antiserum obtain immun balbc mice test cross reactiv norovirus genotyp n result show antiserum demonstr moder cross reactiv gi gii gii howev cross reactiv epidem variant gii gii gii observ addit block antibodi activ gii antisera gii vlp hbgas gii vlp hbgas interact cross block gii vlp hbgas interact gi gii antisera evalu use hbgas vlp block test howev cross block effect observ summari character norovirus gii vlps deriv antisera reveal gii immunogen differ epidem variant | D001789;D017250;D058872;D005759;D029322 | T047;T129;T005;T185;T067 |
34,662,677 | comparison model approach demonstr p mediat signal pathway higher eukaryot quantit model biolog system use petri net technolog experienc renaiss past coupl decad overwhelm major model determinist though under biolog system usual mesoscop level small rather larg employ spars molecular structur spars biolog system accompani random due low molecular densiti intrins random natur phenomena nois experi hand biochem reaction inher uncertain due imprecis vagu kinet paramet stochast method use cope random fuzzi method develop deal uncertainti biolog system lack common voic among research regard best choic model approach particular biolog system main issu address paper choic determinist stochast fuzzi paramet aspect model approach follow reach realist approxim under biolog system measur parallel discrep differ quantit paradigm end use petri net hybrid stochast fuzzi paramet creat quantit model p mediat signal pathway higher eukaryot perform determinist pure stochast fuzzi stochast simul predict behaviour major molecular regul p mediat pathway meanwhil show uncertain kinet paramet precis approxim term cut perform statist analysi simul result measur similar three model approach statist analysi reveal signific deviat determinist pure stochast fuzzi stochast approach biolog compon due rather small size under biolog system turn fuzzi stochast approach appropri model p mediat signal pathway success deal random uncertainti produc quantit result biolog relev | D008954;D049451 | T081;T170;T075 |
34,662,675 | ern neural index chang perform monitor follow attent train pediatr obsess compuls disord evid associ obsess compuls disord ocd alter neural indic perform monitor ie elev neural activ follow error acceler interest error relat negat ern biomark pediatr ocd studi investig degre attent bias train link chang neural measur perform monitor ern correct respons negat crn whether pre post train chang neural indic associ symptom chang youth ocd sampl includ youth year diagnos ocd complet session attent train program pre post train eeg assess perform monitor use cognit emot flanker task emot flanker task individu particip negat rate stimuli pre treatment enhanc salienc threat relat stimuli across youth result indic unlik particip receiv attent control protocol con receiv attent bias modif protocol abm show signific attenu neural activ follow erron correct respons emot flanker task ern amplitud cognit flanker task unchang abm con group attenu ern also link decreas social anxieti depress symptom find highlight relev includ emot salient task investig potenti neural mechan treatment suggest alter neural process under perform monitor target via attent train program pediatr ocd | D000070379;D009771 | T048;T041 |
34,662,674 | say name congruenc month old infant behavior cardiac respons name reduc orient name earli behavior risk marker neurodevelopment disord howev individu instanc infant behavior respons name limit reliabl predict valid physiolog respons heart rate hr deceler may serv sensit metric behavior method first step toward valid hr deceler candid psychophysiolog measur name process examin congruenc behavior cardiac respons name month old typic develop infant infant exhibit greater median hr deceler spent larger proport time hr deceler behavior orient name fail howev maximum hr deceler relat behavior respons find provid preliminari evid specif hr deceler metric may use indic infant respons name may inform psychophysiolog mechan under behavior respons | D009275 | T170 |
34,662,673 | cortic autonom network connect predict symptom myalgic encephalomyelitischron fatigu syndrom mecf myalgic encephalomyelitischron fatigu syndrom mecf repres signific public health challeng given presenc mani unexplain patient symptom research shown mani featur mecf may result dysfunct autonom nervous system an explor role cortic autonom network involv higher order control an function patient mecf healthi control task free condit particip underw rest state quantit electroencephalograph qeeg scalp record eye close condit sourc analysi perform use exact low resolut electromagnet tomographi eloreta lag coher use estim intrins function connect node across frequenc band delta hz theta hz alpha hz alpha hz beta hz beta hz beta hz symptom rate measur use depaul symptom questionnair short form sf health survey graph theoret analysi weight undirect connect reveal signific group differ baselin organ regress result show cognit affect somatomotor symptom cluster rate associ alter topolog patient depend frequenc band find provid evid reduc higher order homeostat regul adapt mecf confirm find address potenti therapeut target manag patient symptom | D015673 | T047 |
34,662,671 | ultrason particl approach target gene deliveri gene therapi wide investig treatment genet acquir infecti diseas pioneer work util viral vector howev suspect caus serious advers event result termin sever clinic trial non viral vector lipid nanoparticl attract signific interest main due success use vaccin current covid pandem although allow safe deliveri come disadvantag target deliveri applic ultrasound ultrasound sensit particl allow direct site specif transfer genet materi organsit interest process term ultrasound target gene deliveri utgd also increas cell membran permeabl enhanc gene uptak review focus advanc ultrasound develop ultrason particl utgd across rang diseas furthermor discuss limit futur perspect utgd | D018014;D014465 | T070;T062;T063 |
34,662,670 | sport practic hypertroph cardiomyopathi run stand still last decad practic sport hypertroph cardiomyopathi hcm consid incompat sinc evid suffici gaug risk associ repeat andor vigor exercis across spectrum hcm addit acknowledg thatrisk stratif tool develop hcm deriv athlet cohort recent epidemiolog studi focus hcm general popul athlet howev de emphas contribut condit risk sport associ sudden death support possibl allow practic sport even profession level certain low risk hcm categori herebi analyz complex interact vigor continu exercis hcm revis avail evid sport elig hcm challeng limit share decis make well potenti harm benefit high personalis exercis schedul subject diagnos complex diseas | D002312;D012420 | T047;T056 |
34,662,661 | isol character neural stem cell fetal canin spinal cord neurogenesi adult mammal occur main subventricular subgranular area brain also report occurr spinal cord studi rat neural stem cell neuroprogenitor cell could obtain primari spinal cord cultur studi cell canin speci date dog repres appropri anim model studi neurogenesi neurolog disord addit anim great affect valu therapeut use neural stem cell repres breakthrough regen veterinari medicin therefor studi aim determin protocol isol cultur character neural neuroprogenitor stem cell deriv spinal cord canin fetus cell isol spinal cord fragment cultur serum free cultur medium supplement egf fgf growth factor cell observ daili optic microscopi analyz morpholog characterist third day vitro possibl observ transluc cell group similar neurospher approxim rang seven day vitro throughout cultur period neurospher develop ribbon peripheri migrat communic neurospher rt pcr reveal cell express characterist gene sox nestin gfap addit gene express cell phenotyp mark immunofluoresc assay protein nestin gfap tubulin iii character neurospher result suggest spinal cord may sourc neural stem cell neural progenitor cell canin fetus cell may interest option neurogenesi neuroregen therapi studi | D004285 | T015 |
34,662,657 | compar scientometr analysi cite articl acta neurochirurgica wien world neurosurgeri acta neurochirurgica anch world neurosurgeri wn journal signific import neurosurg communiti associ intern feder journal carri similar impact factor differ year activ anch start public wn factor allow uniqu opportun delv deep compar scientometr paramet understand evolut neurosurg research | D015706 | T062 |
34,662,656 | develop valid nomogram predict albumin transfus spinal tuberculosi surgeri base propens score match analysi literatur report use periop paramet predict risk albumin transfus spinal tuberculosi surgeri base applic nomogram propens score match psm analysi | D049451;D057216 | T170;T081 |
34,662,655 | hyaluron acid coat pluron fpluron p mix micell target deliveri paclitaxel curcumin hydrophob anticanc drug offer great challeng select system effect transport come import micell offer hydrophob core incorpor drug studi hyaluron acid coat pluron mix micell load paclitaxel curcumin design evalu anticanc activ mcf cell pluron f pf pluron p pp taken prepar mix micell target ligand folic acid fa conjug one end pp form fa pp end hydroxyl group pf oxid aldehyd group result pf cho mix micell prepar pf cho fa pp end aldehyd group use coat micell hyaluron acid materi character use ftir h nmr dls fe sem tem coat micell show spheric shape drug load effici paclitaxel curcumin respect vitro drug releas studi ph dual drug load materi show higher vitro anticanc activ free paclitaxel curcumin result suggest synthes mix micell dual drug show great potenti target deliveri mcf cell | D020099;D008823 | T122;T109 |
34,662,653 | fabric character bamboo shoot cellulosesodium algin composit aerogel sustain releas curcumin feasibl use unmodifi bamboo shoot cellulos bsc produc composit aerogel sodium algin sa fast green way sustain releas curcumin explor first time calcium ion induc sa cross link could effect retain structur stabil aerogel skeleton aerogel character scan electron microscopi fourier transform infrar spectroscopi differenti scan calorimetri encapsul releas curcumin aerogel studi antioxid activ encapsul curcumin investig curcumin even encapsul composit aerogel show sustain releas behavior follow first order rate express interpenetr network structur built bsc sa main hydrogen bond could reinforc cross link caco sa matrix origin characterist bsc composit aerogel well retain thermal stabil mechan properti composit aerogel improv ca induc cross link uncross link composit aerogel exhibit better encapsul effici vitro antioxid activ overal studi first use cellulos bamboo shoot develop aerogel drug deliveri purpos cellulosealgin composit aerogel promis use biocompat carrier drug nutraceut deliveri | D000464;D002482 | T121;T122;T109;T123 |
34,662,652 | crosstalk epigenet mtor gateway new insight pathophysiolog treatment alzheim diseas epigenet current time becom gateway acquir answer question left unansw classic modern genet resolv complex mysteri behind neurodegen disord understand complex behind life threaten cancer present world entir new dimens ad dynam angl otherwis static field genet alzheim diseas one preval neurodegen disord larg found result alter epigenet pathway chang major compris imbal dna methyl level alter acetyl methyl histon often seen cross link metabol regulatori pathway mtor contribut signific pathophysiolog ad review focuss studi interplay mtor regulatori pathway epigenet machineri may elev rate earli diagnosi prove gateway develop effici novel therapeut strategi treatment alzheim diseas earli stage | D044127;D005786;D015398 | T043;T044;T045 |
34,662,650 | lipoic acid supplement associ neural epiderm growth factor like nell associ membran nephropathi lipoic acid alpha lipoic acid thioctic acid popular counter antioxid insulin mimet supplement investig varieti condit includ multipl sclerosi diabet schizophrenia unfortun high grade proteinuria unexpect advers event specif treatment arm clinic trial investig lipoic acid supplement patient multipl sclerosi observ led detect similar patient nephrolog practic describ four biopsi proven case neural epiderm growth factor like nell associ membran nephropathi follow lipoic acid supplement fifth suspect case discontinu lipoic acid support therapi result remiss | D015433;D008063 | T047;T127;T121;T109 |
34,662,649 | shape stabil ellipsoid nanomateri prepar physic deform nonspher shape nanomateri nms repres key attribut control biolog behavior analyz shape stabil time repres signific concern nonspher nms like rearrang thermodynam stabl spheric shape investig ellipsoid nms design physic deform coreshel nanospher compos poli isobutylcyanoacryl chitosan mixtur chitosan thiolat chitosan optim process paramet design ellipsoid nms shape stabil storag investig month differ temperatur c c c nm shape examin analyz aspect ratio imag obtain electron microscopi techniqu result demonstr feasibl design shape persist ellipsoid nms physic deform spheric particl | D048271;D054118;D049329 | T121;T073;T109 |
34,662,648 | surfac energi consider ternari powder blend inhal need optimis dpi formul main research motiv respiratori drug deliveri well establish formul like carrier base blend still show lack effici addit extrins fine excipi extens discuss sinc decad support wide rang solid state characterist understand mechan classifi influenc paramet first part studi aim compar surfac energi lactos fine correspond influenc aerodynam perform respect ternari blend five differ fine lactos qualiti vari origin use distinguish term surfac energi compar regard particl size moistur content chemic composit demonstr crucial influenc adhes properti fine base differ surfac energi second one specif fine lactos qualiti use fundament differ lactos carrier highlight neglig influenc carrier properti extrins fine preferenti capabl excipi drug interact | D004337;D058995 | T074;T122 |
34,662,647 | use atom forc microscopi afm monitor surfac crystal caffein oxal acid cafoxa cocryst compact object monitor surfac crystal disord caffein oxal acid cafoxa cocryst follow exposur elev water vapor pressur accomplish use atom forc microscopi afm disord induc cocryst particl common pharmaceut unit oper mill compact activ solid upon exposur elev water vapor pressur high propens sorb water led rise molecular mobil surfac underw rapid crystal form needl shape crystal cafoxa use afm height phase imag abl direct visual phase transform compact surfac mill compact exhibit higher process induc disord unmil compact therebi acceler surfac recrystal | D002110;D019815 | T130;T121;T109 |
34,662,646 | combin transderm patch solid microneedl improv transderm deliveri primaquin malaria caus various type plasmodium becom global health problem one drug use first line malaria therapi primaquin pmq pmq general administ oral rout howev use pmq oral could potenti caus side effect undergo first pass metabol liver reduc effect therefor necessari develop anoth drug administr rout avoid effect studi first time pmq formul transderm patch transderm deliveri combin solid microneedl dermarol follow sever optim hpmc glycerin use main polym plastic respect specif concentr peg permeat enhanc also optim transderm patch evalu weight uniform thick surfac ph fold endur moistur content moistur absorpt abil bioadhes evalu drug content recoveri pmq releas permeat also investig vitro ex vivo test rat skin tissu import safeti transderm patch also evalu vitro hemolyt vivo irrit test confirm histopatholog examin result show formul show desir physic bioadhes properti fold endur fold result exhibit primaquin releas transderm patch follow vitro ex vivo permeat studi combin dermarol ex vivo permeat studi show improv permeat profil primaquin permeat h zero order kinet first h hemolysi percentag found indic non toxic approach final histopatholog studi show sever tissu damag follow administr approach vivo evalu perform | D004364;D057968 | T074;T121 |
34,662,644 | rapamycin load poli lactic co glycol acid nanoparticl prepar character vitro toxic studi potenti intra articular inject osteoarthr oa common degen joint diseas rapamycin potenti candid oa treatment increas autophagi process implic physiopatholog optim rapamycin profit avoid system side effect intra articular ia administr appear help howev rapamycin high hydrophob natur low bioavail made challeng develop purpos made drug deliveri system overcom limit develop rapamycin load nanoparticl nps use poli lactic co glycol acid emulsionevapor method evalu nps cytocompat toward cartilag chondrocyt synovi membran cell synoviocyt potenti ia administr vitro character rapamycin load nps shown suitabl profil ia administr vitro biocompat nps highlight rapamycin synoviocyt chondrocyt signific toxic observ higher concentr besid synoviocyt sensit rapamycin load nps chondrocyt final observ vitro adapt formul rapamycin load nps could safe suitabl ia inject concentr toxic effect rapamycin encapsul nps articular cell dose depend rapamycin load nps ia administr local retent situ safeti system releas evalu experiment vivo model | D053758;D020123 | T195;T121;T073;T109 |
34,662,643 | mechan jet injector induc plasmid dna uptak contribut shear stress endocytosi administr plasmid dna pdna use pyro drive jet injector allow gene express cell treat tissu howev detail plasmid uptak process remain determin recent theori suggest shear stress enhanc endocytosi pathway pdna intern investig process pdna uptak context pyro drive jet injector base administr way optim gene transfer effici via increas dna uptak gene express signific improv shear stress caus jet generat pdna retain contrarili heparin inhibitor spontan uptak inject dna inhibit gene express jet inject addit treatment typic endocytosi inhibitor chlorpromazin methyl cyclodextrin dimethyl amilorid rottlerin nsc also reduc plasmid express effici context jet inject convers endosom escap context chloroquin treatment increas express effici altogeth result clarifi mechan pdna uptak context jet inject also highlight key role endosom intracellular traffick pdna import find may impact studi gene transfer endocytosi boost effort improv effici safeti jet inject context basic translat applic | D004247;D004705 | T043;T114;T123 |
34,662,642 | volatil zn pb prepar integr micro electrolysi filter copper slag applic remov cr vi aqueous solut studi copper slag treat carbotherm reduct technolog prepar integr micro electrolysi filter imef recoveri zn pb influenc roast condit volatil zn pb perform imef remov cr vi water studi result show increas roast temperatur time dosag coal facilit generat zero valent iron zvi volatil zn pb imef roast c min anthracit best reduct effect cr vi volatil effici zn pb respect prepar imef porous structur poros great number nanomicro size zvi particl generat surfac silic pore super reactiv remov cr vi promot increas imef dosag solut temperatur decreas ph cr vi solut imef present good mechan strength excel long term perform remov cr vi cr vi reduc cr iii miner fecr reaction | D003300;D007854 | T131;T121;T196;T123 |
34,662,641 | adsorpt norfloxacin aqueous solut biochar deriv spent coffe ground master variabl respons surfac method optim adsorpt process studi biochar deriv spent coffe ground scgb use adsorb norfloxacin water biochar properti interpret analysi specif surfac area morpholog structur thermal stabil function group impact ph ion present scgb perform examin adsorpt mode scgb best suit langmuir model r maximum absorpt capac mg g use respons surfac method rsm optim adsorpt also found ph mg l scgb g l compar biochar deriv agricultur corn stalk willow branch potato stem reed stalk cauliflow root wheat straw adsorpt capac scgb time higher less time biochar made salix mongolica luffa spong polydopamin microspher find reveal spent coffe ground biochar could effect remov aqueous solut approach biochar deriv coffe ground would promis eco friend solut util solid wast save cost creat adsorb deal emerg pollut like antibiot | D003069;D009643 | T195;T121;T168;T109 |
34,662,640 | assess integr biomark triplefin fish forsterygion capito inhabit contamin marin water multivari approach presenc multipl chemic aquat ecosystem make evalu real impact biota difficult integr biomark therefor need evalu chemic contribut environment degrad aim present studi evalu respons effect marin pollut use seri biomark multivari analys transcript respons cypa cytochrom p mt metallothionein vtg vitellogenin cypb cytochrom p aromatas branchial hepat histolog alter fulton condit factor cf evalu well metal polycycl aromat hydrocarbon present forsterygion capito auckland new zealand site select along contamin gradient four high contamin site four less contamin molecular respons higher relat express mt cypa gene detect high contamin site panmur sever histolog lesion type found liver fish inhabit type site gill lesion present primarili high contamin site term general health status lowest cf valu overwhelm found fish site panmur multivari approach reveal telangiectasia hyperplasia associ presenc chemic show negat associ cf valu fish three high contamin site affect conclus multivari approach help integr biolog marker blennioid fish thus provid holist view complex chemic mixtur involv futur studi implement analys | D017753;D008668 | T070;T116;T082;T123 |
34,662,639 | high microwav respons co bi feo synergist activ peroxydisulf high effici pollut degrad disinfect mechan enhanc electron transfer cobalt dope bi feo use heterogen catalyst microwav mw co activ peroxydisulf pds system organ contamin purif disinfect simultan due low charg transfer resist fast electron migrat co bi feo show superior catalyt effici activ pds degrad bisphenol bpa initi concentr rang mgl mgl min non radic oxid pathway via electron transfer regim surfac co bi feo domin reactiv speci reaction system benefit energi transfer cross coupl reaction microwav co bi feo mwpds system generat abund reactiv site facilit format surfac bond complex microwav energi absorb co bi feo catalyst promot activ pds product nanobubbl generat nanobubbl increas temperatur local solut promot reaction co bi feo mwpds system also exhibit excel bactericid capabl escherichia coli ecoli catalyst oxid microwav act e coli form physic oxid pressur simultan caus cell damag made bacteri death work provid prospect toward high effici integr contamin purif pathogen microorgan inactiv | D004203;D004785 | T131;T061 |
34,662,638 | enhanc phytoremedi metal loid via spike zvi nanoparticl urban clean strategi ornament plant increas industri urban also trigger environment pollut most unnot case soil pollut due uncontrol contamin toxic element dispers present studi focus aspect studi clean urban soil low cost eco friend way restrict arsenic lead pb mercuri hg contamin four potenti ornament plant catharanthus roseus vinca cosmos bipinnatus cosmos gomphrena globos globosa impatien balsamina balsamina use along zero valent iron zvi nanoparticl fe nps remedi soil spike mg kg pb mg kg hg mg kg pot experi plant divid four group viz control spike spike mg kg zvi np spike mg kg zvi np ftir sem use zvi np character soil plant analys element assess done use icp ms xrf sem among four plant cosmos show maximum accumul toxic element mg kg mg kg pb mg kg hg applic zvi np mg kg dosag found augment plant potenti metal loid accumul without negat hamper growth cosmos observ reduc soil mg kg mg kg pb mg kg hg mg kg spike mg kg zvi np treatment balsamina sensit plant show least metal loid accumul conclus three plant potent enough use togeth better enhanc remov toxic element contamin soil cosmos best amongst urban area | D007501;D053758 | T121;T073;T196;T123 |
34,662,637 | uio zr deriv zirconia abund lattic defect remark enhanc arsenic remov zirconium oxid zro exhibit great potenti remedi arsenic pollut water studi tetragon zirconium oxid zro high lattic defect facil fabric regul zr metal organ framework mof uio sodium acet modul examin adsorb arsenic water benefit synergist effect mesopor structur lattic defect zro exhibit ultrahigh adsorpt capac faster kinet toward arsenat v arsenit iii langmuir adsorpt capac v iii mg g mg g zro exotherm process respect signific outperform report counterpart literatur general mg g faster adsorpt kinet iii v zro defin favor pseudo second order model wide ph furthermor arsenic main captur zro via form zr bond occupi coordin unsatur zirconium atom adsorpt site reveal x ray photoelectron spectroscopi xps spectrum fourier transform infrar ftir spectra analysi studi offer new strategi design ultrahigh perform zr mof deriv adsorb captur arsenic | D001151;D015040 | T131;T121;T196 |
34,662,636 | situ fraction redox speciat arsenic soda lake nhecolndia pantan brazil use diffus gradient thin film dgt techniqu situ fraction redox speciat three differ salin alkalin lake green black crystallin lake pantan nhecolndia brazil perform use diffus gradient thin film dgt result indic present main dissolv form total concentr similar use differ filter membran demonstr speci adsorb dgt devic kda higher concentr labil total observ center lake indic natur organ matter influenc format complex total concentr determin use zro dgt consist concentr ultrafilt water sampl collect black lake howev part data iii obtain grab sampl contrast dgt result differ observ may indic alter speci occur storag period analysi ultrafiltr iii concentr measur dgt black crystallin lake g l g l respect account total dgt inorgan green lake iii concentr signific higher center g l phytoplankton communiti dissolv organ carbon influenc speciat bioavail lake nhecolndia dgt approach use present work abl perform speciat demonstr situ sampl analyt techniqu essenti understand speciat behavior complex natur aquat system | D001151;D060106 | T121;T083;T131;T196;T070 |
34,662,635 | exposur environment concentr natur pyrethrin induc hepatotox assess hepg cell line zebrafish model natur pyrethrin one varieti botan pesticid common use organ ecolog agricultur howev hepatotox natur pyrethrin unknown studi impact natur pyrethrin human hepg cell promin cell model toxic induc hepatotox evalu investig accord ros product mechan dna damag repair report liver toxic natur pyrethrin zebrafish result reveal signific increas ros product suggest oxid stress besid notabl genotox effect oxid induc dna damag observ natur pyrethrin detect neutral comet assay hax oxog stain reveal result oxid dna damag respons cytotox exposur natur pyrethrin hepg cell human observ damag chronic toxic may caus irrevers dna damag sever toxic effect human hepg cell account complic respons dna impair visual observ zebrafish liver oil red stain also demonstr natur pyrethrin induc liver degener liver size chang liver steatosi zebrafish conclus health human endang natur pyrethrin result hepatotox | D011722 | T131;T109 |
34,662,634 | convent biolog treatment remov microplast drink water studi examin remov microplast anthropogen particl surfac water full scale convent drink water treatment plant treatment process compos coagul aluminum hydroxid floccul anthracit sand filtrat chlorin sampl also collect pilot scale biolog filter consist anthracit sand granular activ carbon gac media oper without pre ozon rang differ empti bed contact time ebct particl l water sampl collect duplic use fulli enclos sampl apparatus separ use siev open follow filtrat polycarbon filter particl count use stereomicroscopi character use raman spectroscopi full scale convent treatment remov anthropogen particl compar raw particlesl finish water particlesl coagul floccul sediment account highest remov individu unit process overal remov reduc differ attribut airborn particl deposit occur water detain clearwel expos atmospher via ventil use achiev requir contact time disinfect major particl identifi fiber microplast predomin compos polyest non plastic anthropogen particl primarili cellulos none pilot filter configur examin result signific fewer microplast compar full scale convent filtrat studi illustr remov effici convent treatment may limit consid microfib size | D060766;D018508 | T167;T052;T057 |
34,662,633 | boron origin produc water discharg brazilian coastal water ecolog risk assess marin organ determinist probabilist ecolog risk assess perform boron present coastal water region sebastio channel coast paulo state brazil surround outfal sebastio waterway termin tebar refer area far outfal set ecotox test marin organ lytechinus variegatus arbacia lixula skeletonema costatum asterionellopsi glaciali parablenius pilicorni artemia salina megabalanus coccopoma mysidopsi junia hypnea musciform perform laboratori ecotox test confirm boron present low ecotox lytechinus variegatus sensit speci studi ec mg l observ effect concentr noec mg l accord determinist ecolog risk assess signific environment impact expect consid sensit organ test highest concentr boron found coastal water mg l | D059001;D001895 | T001;T196 |
34,662,632 | analyt method sequenti determin persist herbicid metabolit fish tissu uplc msms novel accur liquid chromatographi tandem mass spectrometri method develop sequenti determin three persist herbicid atrazin atz acetochlor ace metolachlor met seven characterist metabolit desethylatrazin dea deisopropylatrazin dia diaminochlorotriazin dact met oxanil acid met oa met ethanesulfon acid met esa ace esa ace oa fresh fish tissu six fish speci modifi quecher method conduct extract target compound fish tissu matrix match calibr target analyt carri spike level ng g method valid accord codex guidelin cacgl recoveri target analyt relat standard deviat matrix effect rang limit detect quantit ng g respect moreov method success appli analyz concentr target chemic fresh tissu sampl six fish speci n collect four market nan citi guangxi provinc china concentr sampl ng g interest studi first measur dea dia fish liver highest concentr ng g respect method provid basi studi pathway biotransform bioaccumul detoxif exposur pattern ace atz met metabolit aquat environ | D006540 | T131 |
34,662,631 | strategi mitig chlorin disinfect byproduct wastewat treatment plant case studi wastewat treatment plant wwtps full scale assess risk disinfect byproduct dbp format main regul trihalomethan thms haloacet acid haa chlorat inorgan byproduct regul recent eu raw wastewat larg mediumsmal urban area treat singl combin disinfect process ie chlorin peracet acid paa ultraviolet uv radiat sampl execut month seven month mediumsmal wwtps twice month larg one due potenti risk sar cov contamin wastewat sever inactiv method examin dbp analysi due inactiv step stabil thm haa suffer reduct monitor presenc effluent disinfect treatment contrast chlorat level remain unchang inactiv treatment thus raw wastewat effluent examin occurr disinfect treatment result show chlorat residu raw wastewat vari great undetect level high mg l continu monitor dbps perform posit correl chlorin chlorineuv found chang physicochem paramet indic qualiti raw wastewat vari consider depend wwtps influenc byproduct format wwtps chlorin alon combin uv signific increas presenc thms haa chlorat level treat effluent wwtps chang paa paauv dbps diminish complet studi highlight risk chlorat residu raw wastewat pandem also show chemic risk dbp format could reduc chang chlorin disinfect technolog paa paauv particular reclaim water intend agricultur irrig minim dbp residu | D000086382;D018508 | T052;T047;T057;T067 |
34,662,630 | poison calv rear cow treat abamectin aim present studi describ outbreak poison abamectin calv less four month age whose mother treat pour product contain ingredi diagnosi base histori clinic sign absenc macroscop histopatholog find characterist type poison detect abamectin tissu anim submit necropsi base report recommend use caution pour formul contain abamectin cow given birth less four month earlier | D000871;D002418 | T047;T121 |
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