PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,662,331 | ten simpl rule switch face face remot confer opportun estim reduct ghg emiss world face sever acut respiratori syndrom coronavirus sar cov pandem drastic alter peopl live sinc mani countri forc suspend public gather lead mani confer cancel postpon reorgan switch face face remot confer becam inevit ultim solut sustain scientif exchang nation intern level year committe charg organ major french annual confer cover comput biolog area journ ouvert en biologi informatiqu et mathmatiqu jobim despit health crisi succeed chang confer format face face remot short amount time propos simpl rule base experi modifi confer format optim cost effect way addit suggest rule decid emphas unexpect benefit situat signific reduct greenhous gas ghg emiss relat travel scientif confer attend believ even sar cov crisi collect opportun think way approach scientif event longer term | D000086382;D019295;D003226;D058873;D000086402;D049269 | T047;T066;T073;T170;T005;T091;T068;T067 |
34,662,330 | univers valid reduct multiscal stochast biochem system use simpl non elementari propens biochem system consist numer elementari reaction govern law mass action howev experiment character elementari reaction near imposs thus centuri determinist model typic contain rapid revers bind simplifi non elementari reaction function eg micha menten morrison equat although non elementari reaction function deriv appli quasi steadi state approxim qssa determinist system also wide use deriv propens stochast simul due comput effici simplic howev valid condit heurist approach identifi even revers bind molecul protein dna enzym substrat receptor ligand basi live cell find non elementari propens base determinist total qssa accur captur stochast dynam revers bind general howev serious error occur reactant molecul similar level tight bind unlik determinist system case non elementari propens distort stochast dynam bistabl switch cell cycl oscil circadian clock accord deriv altern non elementari propens stochast low state qssa develop studi provid univers valid framework simplifi multiscal stochast biochem system rapid revers bind critic effici stochast simul cell signal gene regul facilit framework provid user friend open sourc comput packag assist automat perform present framework | D003198;D008954 | T066;T075 |
34,662,328 | hypercalcemia cypa gene mutat diagnos nd trimest twin pregnanc case report background loss function mutat cypa gene caus defici cypa enzym involv catabol dihydroxyvitamin patient cypa enzym defici increas risk develop hypercalcemia pregnanc avoid addit vitamin supplement case report provid addit inform manag diagnos patient cypa gene mutat case report primipara woman twin pregnanc admit hospit frequent hypertens crise histori hypercalcemia associ sign symptom except nephrocalcinosi report abnorm discomfort present laboratori test reveal parathyroid hormon level suppress serum calcium level mark increas hydroxyvitamin level upper limit refer rang dihydroxyvitamin level elev suggest vitamin catabol disord genet test perform homozyg like pathogen variant base american colleg medic genet genom guidelin cg pgluli detect cypa gene nm cesarean section deliveri perform due singl intrauterin demis week gestat preterm newborn diagnos transit hypercalcemia hyperphosphatemia howev treat asymptomat conclus patient cypa gene mutat increas risk hypercalcemia fetal demis therefor hydroxyvitamin calcium level monitor routin blood test pregnanc hypercalcemia newborn care evalu treat hypercalciuria lead nephrocalcinosi | D006934 | T047 |
34,662,320 | corticoperiost pedicl flap greater trochant salvag old femor neck fractur children outcom minimum year follow old femor neck fractur ofnf general refer fractur week corticoperiost pedicl flap greater trochant cppf gt design restor blood suppli donor bone ofnf studi aim assess efficaci radiograph result cppf gt treatment ofnf children minimum year follow | D060905;D005265;D005271 | T047;T046;T190;T019;T037;T020 |
34,662,318 | predict anterior cruciat ligament reconstruct revis machin learn analysi util norwegian knee ligament regist sever factor associ increas risk anterior cruciat ligament acl reconstruct revis howev abil accur translat factor quantifi risk revis patient specif level remain elus sought determin machin learn analysi norwegian knee ligament regist nklr identifi import risk factor associ subsequ revis primari acl reconstruct develop clinic meaning calcul predict revis primari acl reconstruct | D059549;D000069550 | T066;T061 |
34,662,315 | comparison photocatalyt activ zno ag zno cu zno ag cu zno tppszno degrad methylen blue uv visibl light irradi studi zinc oxid silver copper dope zinc oxid nanorod synthes simpl templat free precipit techniqu addit meso tetraki sulfonatophenyl porphyrin tpps prepar immobil zno nanorod tppszno synthes photocatalyst character various techniqu x ray powder diffract scan electron microscopi uv visibl spectroscopi diffus reflect spectroscopi fourier transform infrar spectroscopi potenti obtain photocatalyst degrad methylen blue investig uv visibl light irradi result reveal photocatalyt activ tppszno higher pure zno dope zno visibl light irradi | D015034 | T121;T197 |
34,662,314 | determin kinet coeffici treat synthet oili wastewat suspend growth batch fed reactor discharg oili wastewat impart serious threat environ high level concentr chemic oxygen demand cod biochem oxygen demand bod well oil greas difficult treat wastewat due inher toxic inhibitori properti treatabl studi oili wastewat carri petroleum perform present work use batch suspend growth reactor experi conduct use acclimat suspend biomass laboratori environ kinet coeffici determin immens import design reactor oil remov effici observ rang correspond averag mlss concentr rang mgl haldan kinet model found best fit biodegrad oili wastewat acclimatis microorgan present investig kinet co effici includ k k k k calcul experiment data valu compar publish result cite various scientist deriv kinet coeffici valu use understand dynam substrat utilis product biomass effici design biolog system also pilot plant investig real life wastewat similar natur | D014865;D062065 | T069;T057;T083 |
34,662,313 | submerg membran filtrat process coupl powder activ carbon nonylphenol ethoxyl remov combin submerg membran filtrat system powder activ carbon pac investig nonylphenol ethoxyl remov filtrat flux initi powder activ carbon dosag signific effect micropollut remov effici best perform achiev filtrat flux lm h initi powder activ carbon mgl remov effici nonylphenol ethoxyl obtain first hour decreas follow hour respect observ dissolv organ carbon mass adsorb powder activ carbon suspend bulk phase remaind adsorb powder activ carbon deposit membran surfac reveal combin submerg membran filtrat pac could effect solut enhanc remov micropollut water | D002606;D018508 | T052;T121;T057;T109;T196 |
34,662,312 | mechanist insight adsorpt methylen blue particul durian peel wast water studi aim investig adsorpt methylen blue mb particul durian peel wast chemic activ hydrogen peroxid equilibrium data well describ freundlich isotherm model indic mb adsorpt take place predomin multilay heterogen surfac biosorb freundlich adsorpt constant k f n lg respect thermodynam data suggest mb adsorpt occur spontan endotherm enthalpi entropi mb adsorpt obtain kjmol kjmol k respect temperatur rang k base stepwis desorpt method adsorpt mb domin physic interact particular hydrogen bond | D035161;D014874;D018508 | T131;T052;T057;T002 |
34,662,311 | select adsorpt phosphat carboxyl modifi activ carbon electrod capacit deionize capacit deionize cdi consid promis technolog remov phosphat water suffer inferior select electrosorpt perform phosphat current carbon electrod cdi herein achiev high select phosphat remov ternari effluent cl po use nitric acid treat activ carbon ac various modif time pure ac anod cathod novel phosphat select asymmetr cdi reactor result show carboxyl group great graft materi modif vari mol g phosphat select present research higher unmodifi cdi increas increas carboxyl group content highest phosphat select modifi materi almost six time higher pure ac moreov modifi electrod exhibit good regen abil phosphat desorpt effici around adsorptiondesorpt process great stabil cycl experi result demonstr innov applic nitric acid modifi ac effect select remov phosphat mix anion solut open hope window select adsorpt water treatment cdi | D002606;D018508 | T052;T121;T057;T109;T196 |
34,662,310 | studi pollut characterist urban pavement runoff urban pavement runoff becom import pollut sourc endang qualiti urban water paper analyz characterist particl size distribut road deposit sediment rds variat pollut rds content present base continu sampl runoff variat pollut concentr rainfal characterist reveal result show particl group share similar content except group smaller mm howev smaller particl stronger abil adsorb heavi metal zn pb cu weaker abil adsorb chemic oxygen demand cod concentr differ pollut differ relationship rainfal runoff time concentr suspend solid ss decreas steadili runoff time concentr heavi metal increas first decreas first minut runoff best time treat heavi metal ss five day biochem oxygen demand bod total petroleum hydrocarbon tphs concentr main affect rainfal intens result present paper may provid use refer treatment pavement runoff pollut | D019216;D014874 | T131;T196 |
34,662,309 | quantit detect human canin associ bacteroid genet marker urban coastal lagoon contamin water catchment nonpoint sourc faecal pollut major issu affect microbi qualiti receiv water associ occurr rang enter ill human potenti sourc faecal pollut surfac water divers includ urban sewag leak surfac runoff wildlif contamin origin rang host major contribut host requir identif allow target manag public health concern studi two high perform microbi sourc track mst assay hfbac baccan ucdmodif use abil detect host specif bacteroid sr rna marker faecal pollut month studi urban coastal lagoon sydney australia lagoon found contain year round high number human canin faecal marker well faecal indic bacteria count suggest consider human anim faecal pollut high sensit specif hfbac baccan ucdmodif assay togeth manag level pcr inhibit high level dna extract effici obtain lagoon water sampl make marker candid inclus mst toolbox investig host origin faecal pollut urban surfac water | D001439;D012722 | T007;T069 |
34,662,308 | urban stormwat nutrient metal remov small scale green infrastructur explor engin plant biofilt media optimis present studi evalu engin media plant biofilt optimis unveget column experi assess perform loami sand perlit vermiculit zeolit attapulgit media stormwat condit enrich vari nutrient metal reflect urban pollut load sixti column unveget juncus effusus veget use test pollut remov infiltr rate particul discharg effluent clariti plant function respons six sampl round engin media outperform convent loami sand across criteria engin attapulgit consist among best perform report differ exist veget expos differ materi combin media result show net remov nh n po p cd cu pb zn increas n emphas import veget biofilt growth media support increas rate infiltr whilst maintain effect remedi perform offer potenti reduc area requir biofilt current recommend catchment area encourag use small scale green infrastructur urban area research requir assess carri capac engin media laboratori field set particular season chang gaug substrat potenti moistur avail root uptak | D018508 | T052;T057 |
34,662,307 | assess perform intermitt plant filter treat urban wastewat arid climat intermitt plant filter extens biolog purif techniqu aim oxid decontamin urban wastewat low cost minimum environment impact main purpos studi evalu perform intermitt plant filter treat urban wastewat arid condit southern tunisia experiment studi carri pilot scale plant compris five construct gravel sand basin screen urban wastewat effluent intermitt appli daili hydraul load lm sever water qualiti paramet monitor inlet outlet treatment plant averag remov rate chemic biolog oxygen demand total suspend solid ammonium nitrogen orthophosph respect addit result demonstr treatment system capabl remov log unit total faecal coliform faecal streptococci respect result show phragmit australi allow develop biofilm sand filter bed improv purif effici furthermor bio sludg product mechan aerat low energi requir kwm green aesthet ambienc addit particular strength propos pilot plant | D014865;D062065 | T069;T057;T083 |
34,662,306 | effect biochar particl appli bed cours innov permeabl pavement enhanc nitrogen remov coconut shell biochar bamboo biochar ad bed cours permeabl pavement improv nitrogen remov effici expect particular effect innov permeabl pavement increas evapor store rainwat effect rainfal intens ambient temperatur nitrogen remov assess n remov rate pavement biochar ad blank control respect rainfal intens mmh temperatur c total nitrogen remov rate pavement biochar ad blank control respect ad coconut shell bamboo biochar improv denitrif without caus organ matter leach increas rainfal intens decreas temperatur caus less nitrogen remov total nitrogen balanc indic innov pavement convent pavement biochar amend remov mg nitrogen respect suggest ad biochar improv perform innov pavement convent pavement quantit polymeras chain reaction assay bed cours sampl indic ad biochar mark increas abund denitrifi microorgan | D002606;D031787 | T121;T002;T196;T109 |
34,662,305 | product modif hydrochar anaerob digest cattail adsorb ammonium phosphor wastewat water contamin nitrogen phosphorus ion direct consequ eutroph ecosystem object studi investig product hydrochar acet acid sodium hydroxid assist hydrotherm carbon htc various activ method potenti hydrochar adsorb remov nh n po p wastewat result show acet acid sodium hydroxid assist htc activ magnesium chlorid air could improv surfac properti hydrochar acet acid modif generat extens oxygen function group sodium hydroxid modif produc hydrochar high nc ratio surfac aromat treat hydrochar magnesium chlorid could impregn nano magnesium particl hydrochar therebi improv abil remov n p air activ hydrochar result oxygen contain function group nh n po p adsorpt capac hydrochar rang mgg mgg respect adsorpt capac hydrochar swine wastewat similar result artifici wastewat result suggest mg nanoparticl dispers oxygen contain function group play major role adsorpt ion exchang physisorpt | D064751;D032401 | T104;T002;T197 |
34,662,304 | investig role morpholog zn al ldh adsorpt humic acid aqueous solut flake zn al layer doubl hydroxid fldhs microspher ldh mldhs fabric simpl hydrotherm method investig role morpholog zn al ldh humic acid ha adsorpt synthet solut natur water effect process variabl ie contact time initi concentr ha ph competit ion adsorpt investig ha remov mechan also studi two adsorb exhibit differ adsorpt behavior ha presenc absenc background ion may high correl various adsorpt mechan involv comparison ha remov capac two adsorb impli superior adsorpt capabl fldh remov ha synthet solut mgg adsorpt capac mldh higher natur organ matter present natur water sampl contain co exist ion mgg pseudo second order kinet model longmuir isotherm model could adequ interpret ha adsorpt process studi adsorb ldhs exhibit good regener recycl abil | D014874;D018508 | T131;T052;T057 |
34,662,303 | remov microplast wastewat electrocoagul electroflot membran filtrat process wastewat treatment plant wwtps one major vector microplast mps pollut recipi water bodi therefor recoveri mps wwtps extrem import decreas accumul impact aquat system present studi electrocoagul electroflot ecef membran filtrat process investig remov mps wastewat effect differ electrod combin fe al al fe current densiti ph oper time min remov two differ polym particl water investig obtain maximum treatment effici effect pressur bar membran filtrat remov effici also investig maximum remov effici obtain polym type electrod combin al fe initi ph current densiti reaction time min membran filtrat method also display remov effici addit laboratori scale result compar one year averag data plant treat real scale membran result indic propos process suppli maximum remov effici compar convent secondari tertiari treatment method remov microplast | D062065;D014874 | T131;T069;T083 |
34,662,302 | adsorpt model organ compound oc carbon nanotub cnts role oc cnt properti linear solvat energi relationship studi evalu comprehens databas adsorpt polar nonpolar organ compound oc carbon nanotub cnts use linear solvat energi relationship lser techniqu develop predict adsorpt model oc multi wall carbon nanotub mwcnts singl wall carbon nanotub swcnts result show coeffici determin r valu compound higher variabl gmol molecular weight cutoff molecular weight cutoff oc higher gmol trend r valu decreas less among adsorb descriptor coeffici v b term signific descriptor p valu lser equat adsorpt low molecular weight polar nonpolar oc cnts besid k ow normal k valu signific impact regress lser model indic hydrophob interact sole mechan adsorpt oc cnts last swcnts exhibit higher polar oc uptak mwcnts attribut polar surfac swcnts suggest high oxygen content | D037742 | T104;T073 |
34,662,301 | chronic toxic environment risk assess antivir ceriodaphnia dubia raphidoc subcapitata antivir drug class medic use treat viral infect due widespread use especi case pandem limit human metabol antivir detect multipl environment matric studi aim evalu chronic effect acyclovir efavirenz lamivudin zidovudin use ceriodaphnia dubia raphidoc subcapitata result r subcapitata show follow toxic zidovudin ic mg l acyclovir ic mg l lamivudin ic mg l efavirenz ic mg l result chronic bioassay c dubia demonstr zidovudin least toxic ec mg l follow acyclovir ec mg l lamivudin ec mg l efavirenz ec mg l speci shown sensit efavirenz risk quotient rq calcul efavirenz rq greater speci lamivudin rq greater c dubia repres high ecolog risk organ antivir pose signific environment risk aquat organ taken consider futur monitor water sourc | D033361;D014874 | T131;T204 |
34,662,300 | effect foul resist heat exchang crystal form caco hard circul cool water electrostat field altern current electr field effect high voltag electrostat field high voltag altern current electr field heat exchang surfac foul condit hard water investig ca concentr two water condit mmoll mg concentr mmoll mmoll respect hco concentr chang mg concentr x ray diffract scan electron microscop result confirm main crystal phase scale sampl consist calcit aragonit high voltag electrostat treatment promot scale growth water qualiti condit howev high voltag altern current electr field treatment show good scale inhibit effect water qualiti condit scale inhibit effect best ca mg concentr mmoll averag scale inhibit rate reach calcit content scale sampl signific higher aragonit mg affect growth solubl crystal convers high voltag altern current electr field treatment effect extend foul induct period adher scale heat exchang surfac favor heat exchang foul | D006358;D014867 | T070;T121;T197 |
34,662,299 | remov multipl metal ion wastewat multifunct metal organ framework base trap design prepar multifunct adsorb practic wastewat treatment still enorm challeng remov multipl metal ion wastewat develop broad spectrum metal ion trap name uio edta incorpor ethylenediaminetetraacet acid robust uio adsorpt experi kind heavi metal ion includ hard acid mn ba al cr fe borderlin acid co ni cu zn pb sn bi soft acid ag cd hg two kind dissolv miner mg ca show trap effect batch adsorpt process breakthrough process ph valu remov effici metal ion within min maximum static adsorpt capac repres metal ion cr hg pb mg g respect adsorpt kinet fit well pseudo second order model indic chemic adsorpt rate determin step adsorpt process meanwhil materi show high stabil recycl remov effici three repres metal still maintain five consecut adsorpt cycl | D000073396;D019216;D014874 | T131;T196;T109 |
34,662,298 | whole cell microalg cyanobacteri array biosensor monitor cd cr zn aquat system bioavail content metal aquat system becom critic assess toxic effect metal accumul environ consid need rapid measur optic microalg cyanobacteri array biosensor develop use two strain microalga mesotaenium sp strain cyanobacteria synechococcus sp detect cd cr zn aquat system microalg cyanobacteri cell immobil well micropl use sol gel method use silica optimum oper condit biosensor array exposur time storag stabil ph multipl metal effect test min exposur time yield optimum fluoresc valu metal toxic increas decreas ph result low relat fluoresc decreas increas ph result higher relat fluoresc optimum storag time biosensor strain week microalg cultur week cyanobacteri cultur c storag temperatur metal mixtur show less effect inhibit relat fluoresc microalgalcyanobacteri cultur display antagonist behavior among metal test singl unit photosynthet array biosensor valuabl tool detect multi metal aquat system | D015374;D000458;D019216;D058086 | T007;T204;T196;T075;T059 |
34,662,297 | model effect rainfal pattern runoff control perform permeabl pavement implement low impact develop lid urban area necessari quantifi actual effect lid facil studi coupl hydrolog hydrodynam numer model util investig runoff control effect permeabl pavement citi centr shijiazhuang china two group design rainfal event durat differ rainfal amount peak rainfal intens locat present effect permeabl pavement demonstr reduct total runoff volum water depth inund area result indic rainfal amount main factor affect runoff control permeabl pavement effect decreas increas rainfal amount peak intens coeffici moreov permeabl pavement effect reduc residenti waterlog area proport inund area depth consider diminish studi reveal respons runoff control permeabl pavement differ rainfal pattern essenti support design practic oper permeabl pavement | D062070;D011891 | T070;T090 |
34,662,296 | import organ carbon coadjut transport pollut dissolv organ carbon doc physicochem paramet wide use evalu surfac water qualiti howev role agent transport transfer pollut sometim still disregard heterogen composit doc predomin compos humin humic fulvic acid render inher capac bind organ inorgan pollut import featur knowledg present futur condit aquat environ concern author conclud doc control agent mobil metal phosphorus herbicid pesticid among other nevertheless physic chemic condit water column sediment immobil contamin make doc less solubl hamper format doc pollut complex mini review intend present import doc quantif inform associ water contamin could render unavail uptak | D004785;D010575;D014874 | T131 |
34,662,291 | mild advers event sputnik v vaccin russia social media content analysi telegram via deep learn limit amount data safeti profil covid vector vaccin gam covid vac sputnik v previous infodemiolog studi show social media discours could analyz assess concern advers event ae caus drug | D000086382;D000077321;D061108;D014612 | T116;T047;T066;T121;T129;T170;T067 |
34,662,290 | drink social media use among worker covid pandem restrict five wave longitudin studi covid pandem restrict everyday life mani peopl worldwid also affect alcohol consumpt pattern leisur activ includ use social media | D000437;D000086382;D061108 | T048;T047;T170;T067 |
34,662,289 | identif social environ govern guid use offici covid contact trace app three quantit survey studi offici contact trace app implement recommend use across nation track contain spread covid app effect peopl will use accord mani attempt made motiv citizen make use offici recommend app | D000086382;D063731 | T047;T170;T067 |
34,662,286 | covid treatment sold onlin without prescript requir unit state cross section studi evalu avail safeti market medic covid pandem increas onlin purchas heighten interest exist treatment dexamethason hydroxychloroquin lopinavir ritonavir tout potenti covid treatment | D000998;D000086382;D003132;D004335;D020407 | T047;T121;T057;T089;T064;T097;T073;T170;T078;T081;T067 |
34,662,284 | danger benefit social media e profession health care profession scope review wit evolut social media sm use worldwid among general popul popular sm also embrac health care profession hcps context sm evolut exponenti growth user scope review summar recent find e profession hcps | D061108 | T170 |
34,662,278 | enhanc physic thermodynam properti dna storag set end constraint explos data dna consid ideal carrier storag due high storag densiti howev low qualiti dna set hamper widespread use dna storag work propos new method design high qualiti dna storag set first random switch doubl weight offspr strategi introduc doubl strategi black widow optim algorithm dbwo experiment result benchmark function show explor exploit abil dbwo great improv previous work second dbwo appli design dna storag set compar previous work lower bound storag set boost final improv poor stabil sequenc end constraint propos design dna storag set measur number hairpin structur melt temperatur minimum free energi evalu innov constraint dbwo construct larger number storag set also enhanc physic thermodynam properti dna storag set | D000465;D004247 | T170;T114;T123 |
34,662,277 | lead free ultrason phase array transduc human heart imag substanti advanc made recent year lead free piezoelectr materi date still challeng make true medic imag ultrason array transduc center frequenc human heart imag high qualiti lead free ba ca ti zr textur ceram plate size mm piezoelectr constant pcn phantom imag intern clinic human heart imag demonstr lead free phase array produc compar imag qualiti commerci pzt h ceram base phase array transduc demonstr practic use lead free materi replac pzt ceram phase array transduc medic imag applic | D014159;D014465 | T070;T074 |
34,662,276 | relationship communiti composit product invas resist semi natur bacteri microcosm common garden experi inocul standardis growth medium synthet microbi communiti ie construct individu isol use dilut cultur suggest abil communiti resist invas addit microbi taxa predict overal communiti product broad defin cumul cell densiti andor growth rate howev best knowledg common garden studi yet investig relationship microbi communiti composit invas resist microcosm whose composit differ reflect natur rather laboratori design variat conduct experiment invas two bacteri strain pseudomona fluorescen pseudomona putida laboratori microcosm inocul differ mixtur bacteria deriv natur occur microbi communiti collect field use rrna gene amplicon sequenc characteris microcosm start composit high throughput assay communiti phenotyp includ product invad surviv determin product key predictor invas resist natur microbi communiti substanti mediat effect composit invas resist result suggest similar general principl govern invas artifici natur communiti factor affect resid communiti product focal point futur microbi invas experi | D064307 | T032;T001;T028 |
34,662,275 | anecdot increas patient willing take biolog medic psoriasi patient often apprehens start biolog medic psoriasi typic fear includ anxieti regard possibl side effect reluct accept proven efficaci studi aim evalu patient willing take biolog medic psoriasi present clinic trial evid anecdot prospect onlin survey studi perform patient psoriasi patient random receiv clinic trial evid biolog medic efficaci safeti anecdot singl patient posit experi respons record point likert scale evalu use kruskal walli test follow dunn test result indic present anecdot alon combin clinic trial evid may effect way improv patient willing take biolog medic psoriasi | D001688;D011565 | T047;T121;T123 |
34,662,274 | updat biolog psoriasi clinic practic biolog impact clinic manag moder sever psoriasi review articl highlight new data find phase clinic trial n publish may februari data efficaci us food drug administr approv biolog treat psoriasi affirm durabl skin clearanc presenc comorbid treatment gap articl aim provid clinician date knowledg biolog perform focus skin diseas clearanc time skin diseas clearanc loss respons relaps treatment emerg advers event teae recent trial data review focus treatment il inhibitor il inhibitor | D001688;D011565 | T047;T121;T123 |
34,662,273 | translat aad npf guidelin care psoriasi attent comorbid april american academi dermatolog aad nation psoriasi foundat npf releas set guidelin regard manag psoriasi focus extracutan manifest comorbid mental health psychosoci well qualiti life qol guidelin provid date evid screen treatment recommend diseas comorbid purpos review present recommend form easili appli clinic practic | D011565;D011788 | T047;T078 |
34,662,270 | enhanc identif opioid involv health outcom use nation hospit care survey data object report document develop nation hospit care survey nhcs enhanc opioid identif algorithm algorithm use identifi opioid involv opioid overdos hospit encount addit algorithm use identifi opioid opioid antagonist use revers opioid overdos naloxon treat opioid use disord naltrexon | D000701;D000083682 | T037;T131;T121;T109 |
34,662,269 | machin learn medic code healthcar survey object medic code translat healthcar inform numer code expens time intens exploratori studi evalu use machin learn classifi perform autom medic code larg statist healthcar survey | D059019;D000069550 | T058;T057;T066 |
34,662,268 | death rate marit status lead caus death unit state object report present age adjust death rate marit status marri never marri widow divorc among adult age rate caus mortal present lead caus death | D004243;D008393 | T079;T055;T072;T032;T054;T081;T033;T062;T080 |
34,662,267 | aminipila luticellarii sp nov anaerob bacterium isol pit mud strong aromat chines liquor emend descript genus aminipila novel mesophil aerotoler anaerob bacterium design jn isol pit mud strong aromat chines liquor accord rrna gene sequenc analysi highest sequenc similar aminipila butyrica dsm gc content genom dna mol cell gram stain negat slight curv rod flagella optimum growth observ c ph without extra addit nacl strain jn util amino acid l alanin l arginin l asparagin l lysin l methionin l serin l threonin malat pyruv use l arginin l lysin produc acet butyr h co major cellular fatti acid strain jn c c dma c cis dma carbohydr composit cell wall predomin includ galactos glucos rhamnos base phylogenet phenotyp physiolog biochem characterist strain jn classifi repres novel speci within genus aminipila name aminipila luticellarii sp nov propos type strain jn ccam jcm | D000434;D010802;D012988 | T062;T168;T067;T078 |
34,662,266 | mangrovicoccus algicola sp nov algin lyas produc marin bacterium gram stain negat non motil ellipsoid bacterium design hb isol brown alga collect hainan provinc pr china growth observ c optimum c ph optimum ph presenc wv nacl optimum predomin isoprenoid quinon q major fatti acid c c c c c cyclo c polar lipid contain diphosphatidylglycerol phosphatidylglycerol phosphatidylethanolamin phosphatidylmethylethanolamin unidentifi phospholipid two unidentifi glycolipid three unidentifi aminophospholipid size draft genom mbp gc content mol phylogenet analysi rrna gene sequenc indic strain hb belong genus mangrovicoccus closest phylogenet relat speci mangrovicoccus ximenensi tlg similar whole genom averag nucleotid ident ani valu silico dna dna hybrid valu combin phylogenet related phenotyp genotyp featur support conclus strain hb repres novel speci genus mangrovicoccus name mangrovicoccus algicola sp nov propos type strain hb mccc k kctc | D010802;D011133 | T062;T116;T126;T078 |
34,662,265 | acetobact garcinia sp nov acet acid bacterium isol ferment mangosteen peel thailand two isol ms su ms su obtain ferment mangosteen peel vinegar suggest constitut new speci assign genus acetobact base result rrna gene sequenc two isol show highest sequenc similar acetobact tropicali nbrc acetobact senegalensi lmg howev calcul similar valu lower threshold speci demarc phylogenet analysi show branch two isol separ acetobact speci two isol constitut new speci genus acetobact genom dna isol ms su sequenc assembl genom isol analys result show highest averag nucleotid ident valu acetobact papaya jcm highest digit dna dna hybrid valu acetobact fallax lmg lower cutoff valu speci delin phylogenet tree base genom sequenc show lineag isol ms su close relat papaya jcm acetobact suratthaniensi tbrc separ branch two speci addit two isol could distinguish type strain close relat speci phenotyp characterist maldi tof profil therefor two isol ms su tbrc lmg ms su tbrc assign independ speci within genus acetobact name acetobact garcinia sp nov propos two isol | D000091;D029762;D010802 | T007;T002;T062;T078 |
34,662,263 | control peer associ permiss attitud drug use integr model explain illicit drug use china sinc synthet drug replac opioid becom popular illicit drug china object explain illicit drug use contemporari china research develop integr theoret model includ control theori differenti associ theori normal theori method studi draw first hand data collect drug user four compulsori drug detoxif institut china result low self control increas drug use frequenc heighten associ drug use friend permiss attitud drug use simultan howev famili attach indirect influenc drug use frequenc via permiss attitud drug use drug use friend conclus contribut result show influenc self control famili attach fulli mediat drug use friend permiss attitud drug use studi provid detail pictur mechan self social control influenc drug use frequenc contribut larger bodi scholarship integr criminolog theori understand drug use behavior china implic find scientif effect drug treatment program also discuss | D013287;D019966 | T131;T048;T033;T109 |
34,662,262 | neuromotor activ inhibit zebrafish earli life stage exposur environment relev concentr caffein caffein caf neuroact compound found surfac water concentr rang nanogram microgram may induc advers effect aquat vertebr thus aim studi evalu potenti caf affect fish earli life stage wide concentr rang includ occur level surfac water specimen zebrafish earli life stage expos caf h surviv development alter locomotor activ acetylcholinesteras activ evalu caf induc mortal embryo unabl hatch larva hatch lc h mgl tail deform observ organ expos concentr mgl edema found concentr mgl caf also decreas total swim time distanc move expos organ loec mgl locomotor inhibit may associ acetylcholinesteras inhibit observ concentr mgl therefor hazard caf fish popul deserv attent sinc unexpect effect neuro behavior paramet occur concentr often detect natur aquat ecosystem | D014874;D015027 | T131;T013 |
34,662,261 | influenc drink water qualiti format corros scale lead bear drink water distribut system lead drink water occur drink water distribut system dwds lead pipe use servic line use data gather differ canadian citi link drink water qualiti composit corros scale obtain exhum lead pipe servic municip data present encompass year span detail layer profil analysi solid present lead bear servic line differ layer within corros scale form insid lead pipe identifi thorough character result obtain clear show corros layer direct contact drink water rich lead oxid phase aluminosil contrast lead carbon main phase present corros scale direct contact metal lead pipe heterogen phase distribut correl radial distanc corros scale watersolid interphas water qualiti servic municip statist analysi suggest dissolv al mn cu ni accumul corros scale preferenti accumul specif element heavili depend distinct municip water qualiti | D060766;D014874 | T167;T131 |
34,662,256 | dbf depend kinas ddk ate post initi event dna replic dbf depend kinas ddk well establish essenti role origin dna replic phosphoryl activ replic mcm helicas also act respons mutagen dna repair well key step meiosi recent studi indic addit mcm helicas ddk phosphoryl sever substrat elong stage dna replic upon replic stress howev activ ddk essenti viabil dbf depend kinas also emerg key factor regul genom wide origin fire replic coupl chromatin assembl review summar recent progress understand divers role ddk | D018797;D004261;D029701 | T116;T045;T123 |
34,662,254 | presum recurr mewd follow covid vaccin present unusu case recurr multipl evanesc white dot syndrom mewd follow coronavirus covid vaccin | D000086402 | T005 |
34,662,252 | oxid degrad perturb physico chemic properti hemoglobin cigarett smoker threat differ biomolecul cigarett smoker develop structur modif hemoglobin hb modif enabl hb undergo higher rate auto oxid lead generat intracellular ros | D000074285 | T033;T098 |
34,662,248 | non target effect radiat person perspect role exosom evolv paradigm radiat induc non target effect nte implic varieti area relev radiat biolog evalu various cargo associ exosom signal work synergist initi propag non target effect includ genom instabl bystand effect | D055354;D000067128;D011832 | T026;T047;T037 |
34,662,246 | prenyl bibenzyl chines liverwort radula apiculata three new prenyl bibenzyl seven known congen purifi chines liverwort radula apiculata structur identifi analysi spectroscop data comparison report nmr data isol compound test sever human cancer cell line adriamycin serv posit control | D031883;D001632;D035926 | T002;T109 |
34,662,244 | network pharmacolog experiment investig rhizoma polygonati extract target kinas herbzym activ potent drug deliveri rhizoma polygonati huangj rp use long histori mani chemic compon induc anti cancer anti age anti diabet anti fatigu prevent diseas act nutrit sourc food investig rp extract combin kinas inhibitor anti cell growth blockad pathway target kinas experiment investig network pharmacolog analysi appli test potent kinas mediat signal herbzym activ determin substrat optic densiti measur extract process rp inhibit cell growth much greater manner alon appli combin inhibitor mtor egfr moreov process method rp mount tai rp mount tai play essenti role herbzym activ phosphatas suggest interfac also essenti addit chemic compon network pharmacolog analysi show chemic compon target network involv akt mtor consist experiment valid final egfr inhibitor could associ nano extract rp mount tai signific affect phosphatas herbzym activ vitro thus process extract rp mount tai may play dual role inhibit cell prolifer signal chemic compon nanoscal herbzym phosphatas activ inhibit kinas includ mtorakt potent drug deliveri kinas inhibitor | D031384 | T002 |
34,662,243 | relationship peripher central auditori abil iron defici anemia adolesc girl studi evalu peripher hear central auditori process abil indian adolesc girl iron defici anemia ida | D000740;D013067 | T047;T041 |
34,662,242 | shot learn deform imag registr dct imag develop rapid accur deform imag registr dir approach onlin adapt radiotherapi | D000077321;D012119 | T039;T066 |
34,662,235 | comparison fall dizzi handicap vestibular diagnosi pauciti data direct compar fall rate dizzi handicap differ vestibular diagnos purpos studi compar fall rate dizzi handicap common vestibular diagnos encount among cohort vestibular patient singl institut | D000058;D004244 | T184;T037 |
34,662,233 | choos right tool genet engin clinic lesson chimer antigen receptor cell cell modif gene encod chimer antigen receptor car cell shown tremend promis treatment b cell malign success translat car cell therapi tumor type includ solid tumor next big challeng field advanc second next generat car cell compris multipl genet modif sophist method tool engin cell develop viral vector especi retrovirus lentivirus tradit use car cell engin due high transduct effici howev limit genet cargo high cost product good manufactur practic gmp condit high regulatori demand obstacl widespread clinic translat overcom limit differ nonvir approach explor preclin clinic level includ transposontransposas system mrna electropor nonintegr dna nanovector genom edit tool allow effici knockout particular gene andor site direct integr car andor transgen genom also evalu car cell engin review discuss develop viral nonvir vector use generat car cell focus advantag limit also discuss lesson learn clinic trial use differ genet engin tool special focus safeti efficaci | D009369;D000076962 | T192;T191;T116;T129 |
34,662,232 | success stori challeng ahead hematopoiet stem cell gene therapi hemoglobinopathi diseas model gene therapi relat novel field amount around four decad continu growth good bad moment current field enter clinic arena ambit fulfil promis perman fix incur genet disord hemoglobinopathi target diseas hematopoiet stem cell hscs target cell genet intervent major share research effort toward effici implement gene therapi dissect hsc biolog improv gene transfer gene express technolog evolv almost synchron manner point two field seem function intercal review focus specif develop gene therapi hemoglobin disord look gene addit gene correct strategi may domin field hsc direct gene therapi near futur transform therapeut landscap genet diseas | D018380;D006453 | T047;T061 |
34,662,229 | gene therapi made germani histor perspect analysi status quo recommend action german societi gene therapi gene therapi success appli treat sever inherit acquir disord although research develop suffici well fund germani output scientif public patent compar lead nation gene therapi countri lag notic behind regard number clinic studi commerci gene therapi product articl give histor perspect develop gene therapi germani analyz current situat standpoint german societi gene therapi dg gt defin recommend action would enabl countri generat biomed econom advantag innov sector instead mere import advanc therapi medicin product inter alia propos harmon simplifi regulatori licens process enabl faster access advanc therapi establish novel coordin support fund structur facilit network key player center would provid necessari infrastructur know translat cell gene therapi patient one hand pave way commerci promis innov technolog henc cours action would benefit german biotech pharma landscap also societi patient need new treatment option | D015316 | T061 |
34,662,227 | multimodular optim chemic regul cell switch demonstr flexibl interchang natur immun cell signal domain immun cell base therapi induc potent antitumor effect also often associ sever toxic previous develop pd base small molecul regul revers cell activ switch control activ cellular immunotherapi product chemic regul sh deliv inhibitori tail crash switch reli noncoval interact switch sh domain phosphoryl itam motif either chimer antigen receptor cell receptor interact immunoreceptor tyrosin base inhibit motifswitch motif itimitsm contain pd domain present crash switch induc robust inhibit cell signal crash mediat suppress cell activ revers small molecul induc switch proteolysi aim develop improv second generat switch system analyz possibl space immun cell receptor dock inhibitori signal domain allow control cell activ import analys demonstr inhibitori domain potent suppress antigen receptor signal primari human cell deriv inhibitori receptor pd btla endogen express cell includ itimitsm contain inhibitori domain deriv receptor present myeloid cell addit demonstr physic proxim inhibitori domain antigen receptor crucial effici suppress cell activ switch design employ sh domain direct interact itam motif antigen receptor effici revers inhibit cell function data demonstr flexibl interchang natur immun cell signal domain inform design synthet proxim base switch system superior dynam rang | D013601;D018909 | T025;T087 |
34,662,226 | capsid engin central nervous system direct gene therapi adeno associ virus vector close gap knowledg caus neurodegen disord pave way toward innov treatment strategi among gene therapi emerg top candid convent gene therapi genom edit approach develop great number human clinic trial ongo alreadi year ago first gene therapi neurodegen diseas spinal muscular atrophi type sma obtain market approv realiz innov strategi gene therapi deliveri tool key asset focus recombin adeno associ virus aav vector report strategi improv first generat vector current effort focus viral capsid modifi host vector interact aim increas efficaci target cell transduct simplifi vector administr reduc risk vector dose relat side effect | D002213;D019636 | T017;T047 |
34,662,224 | thc legal status widespread avail safeti concern delta tetrahydrocannabinol thc chemic function similar delta tetrahydrocannabinol thc primari psychoact cannabinoid cannabi plant current wide avail counter across unit state due unregul sale howev product question legal status base current us law thc consid schedul drug feder drug enforc administr dea despit design thc product eg gummi edibl oil vape larg unregul sold gas station onlin marketplac often outsid author dispensari market legal hemp product problem aris purpos misinterpret farm bill interpret legal non thc cannabinoid notabl thc widespread avail thc product without health consequ lack regul mean requir warn label packag protect place mandat laboratori analysi assur label accuraci product puriti thc produc physiolog toxicolog effect similar thc high dose exposur thc eg consum full bag thc gummi result recent report medic emerg includ call poison control center present emerg depart pediatr patient arriv unconsci unrespons sever state regulatori agenc call legisl regul thc littl progress occur nation thus far | D002186;D002188 | T167;T121;T002;T109 |
34,662,221 | genom edit er hibit fusion report cell line identif er modul via high throughput screen cetsa estrogen receptor er target intens pharmacolog intervent toxicolog biomonitor current method direct quantifi cellular level er involv antibodi base assay labor intens limit throughput studi generat post translat report cell line refer mcf er hibit fuse small pro luminesc nanoluciferas nluc tag hibit c terminus endogen er mcf cell tag allow luminesc detect quantif endogen er protein addit complementari nluc enzym fragment mcf er hibit cell line optim quantit high throughput screen qhts identifi compound reduc er level addit cell line optim qhts cellular thermal shift assay identifi compound bind thermal stabil er interrog mcf er hibit assay ncat pharmacolog collect npc approv drug identifi compound potent reduc thermal stabil er novel post translat report cell line provid uniqu opportun profil larg pharmacolog toxicolog compound librari effect er level well assess direct compound bind receptor thus facilit mechanist studi compound exert biolog effect er | D047628;D057166 | T192;T116;T059 |
34,662,220 | long term morpholog chang velum nasopharynx patient cleft palat investig long term morpholog chang soft palat length nasopharynx patient cleft palat hypothes would differ morpholog develop soft palat nasopharynx patient without cleft palat development chang would negat affect soft palat length pharyng depth ratio involv velopharyng closur patient cleft palat | D002971;D002972;D014681 | T047;T019 |
34,662,219 | outcom follow particip support base summer camp children stutter self help support activ often recommend peopl stutter grow interest understand whether experi might benefici children stutter purpos studi explor potenti impact particip camp say overnight support base summer camp experi children stutter measur chang score overal assess speaker experi stutter oas | D013342 | T048;T047;T184 |
34,662,218 | particip prefer reason want feedback individu genet research result hiv tb genom studi case studi botswana feedback individu result genom research ethic issu howev genet result african particip would like receiv remain unclear qualit studi conduct collect data adolesc parentscaregiv adolesc enrol genom studi botswana almost particip want receiv genet result parent caregiv want receiv result across categori genet condit discuss studi adolesc reluct receiv result sever non prevent unaction condit particip express differ reason want feedback result includ awar improv lifestyl accept one situat prepar futur find also reveal particip context relat empower import consid interpret prefer feedback result | D023281;D015658 | T091;T047 |
34,662,217 | tissu mobil doubl sourc vibrat semiocclud vocal tract exercis neck face surfac acceler studi purpos studi primarili aim observ possibl tissu mobil facial neck chest tissu caus differ doubl sourc vibrat semiocclud vocal tract exercis dsv sovt anoth goal inspect degre self perceiv sensat massag like sensat method fifti five particip engag set sever dsv sovt phonat silicon tube submerg cm water surfac b acapella choic devic c lip trill tongu trill self perceiv massag like sensat also assess exercis perform three loud level tissu mobil signal captur four acceleromet place four differ bodi region cheek b neck c thyroid cartilag suprastern notch result differenti effect dsv sovt tissu mobil four observ depend variabl tissu oscil modul frequenc amplitud jitter shimmer show signific three way interact general amplitud frequenc tissu oscil modul increas loud self perceiv massag like sensat show high signific differ dsv sovt conclus dsv sovt mobil tissu type exercis loud level bodi region produc effect tissu oscil variabl acapella devic produc largest amplitud vibrat lowest frequenc regular oscil tissu water resist therapi show irregular tissu oscil control variabl like relev obtain best outcom patient | D014732;D014833 | T070;T080 |
34,662,216 | two new coumarin branch zanthoxylum schinifolium two new coumarin isol methanol extract zanthoxylum schinifolium branch structur compound elucid isopentenyl benzoyl coumarin isopentenyl benzoyl coumarin base extens spectroscop analysi includ ir nmr ms inhibitori activ compound hela hepg cell line describ | D032106 | T002 |
34,662,215 | systemat review descend serotonerg project modul spinal nocicept chronic neuropath pain spinal cord stimul chronic neuropath pain debilit ordeal patient worldwid pharmacolog treatment efficaci still limit mani pharmacolog intervent neuropath pain often fail insight under mechan role identifi receptor utmost import import target improv treatment neuropath pain descend serotonerg system project modul nocicept signal dorsal horn also use last resort treatment like spinal cord stimul scs descend serotonerg project known involv pain reliev effect systemat review summar involv serotonerg system nocicept modul healthi adult rodent chronic neuropath rodent summar avail literatur serotonerg system scs treat neuropath rodent medlin embas pubm databas use search articl descend serotonerg modul nocicept signal spinal dorsal horn normal adult rat main inhibitori mediat hta htb htc ht ht receptor upon injuri neuropath rat descend serotonerg modul becom facilitatori via activ hta htb ht receptor analgesia due neuromodulatori intervent like scs restor inhibitori function descend serotonerg system involv ht ht ht receptor result systemat review provid insight suggest pharmacolog neuromodulatori treatment neuropath pain base target select serotonerg receptor relat descend modul nocicept signal spinal dorsal horn novel develop scs paradigm descend serotonerg system import target mechan base stimul induc analgesia | D009437;D062187 | T047;T184;T061 |
34,662,212 | analysi six tonb gene homolog bacteroid fragili reveal tonb essenti surviv experiment intestin colon intra abdomin infect opportunist anaerob pathogen commens human larg intestin tract bacteroid fragili strain r contain six predict tonb protein term tonb four exbb ortholog exbb five exbd ortholog exbd inner membran tonbexbbexbd complex harvest energi proton motiv forc p tonb c termin domain interact transduc energi outer membran tonb depend transport tbdts howev tonb role activ near one hundr tbdts nutrient acquisit b fragili intestin colon extraintestin infect establish studi show growth abolish tonb mutant heme vitamin b fe iii ferrichrom starch mucin glycan n link glycan use substrat growth vitro genet complement tonb mutant tonb gene restor growth substrat tonb tonb tonb tonb tonb singl mutant show growth defect indic function compens lack tonb demonstr tonb alon drive tbdts involv transport essenti nutrient tonb mutant sever growth defect mous model intestin colon compar parent strain intestin growth defect enhanc tonb tonb doubl mutant strain complet lost abil colon mous intestin tract compar parent strain tonb tonb tonb tonb mutant signific affect intestin colon moreov surviv tonb mutant strain complet erad rat model intra abdomin infect taken togeth find show tonb essenti surviv vivo genet organ tonb tonb tonb tonb tonb gene ortholog indic may interact periplasm nonreceptor outer membran protein physiolog relev defin anaerob ferment metabol yield lower p aerob respir b fragili reduc redox state periplasm space contrast oxid environ aerob remain determin divers system tonbexbbexbd ortholog encod b fragili increas sensit pmf relat aerob bacteria allow harvest energi anaerob condit | D005810 | T028 |
34,662,211 | host host group streptococcus transmiss caus infect lamina propria epithelium upper respiratori tract myd defici mice understand protect immun respons onset group streptococcus respiratori infect investig whether myd ko mice suscept acut infect transmiss commingl mice intranas group streptococcus gas inocul myd recipi mice increas gas load nasal caviti throat reach mean throat colon cfuswab mean gas load cfu nasal caviti day beyond day myd recipi mice becam moribund mean cfuswab cfu gas throat nasal caviti respect system gas infect occur coupl day upper respiratori infect gas infect lip gingiv sulcus incisor teeth lamina propria turbin nasal caviti nasopharyng tract epithelia cblj recipi mice low level gas nasal caviti throat direct nasal gas inocul myd mice caus gas infect main lamina propria turbin contrast cblj mice gas inocul gas bacteria nasal caviti lamina propria turbin thus myd mice high suscept acut lethal gas infect transmiss myd signal critic protect respiratori tract lamina propria nasal nasopharyng epithelia gas infect | D054884 | T040 |
34,662,210 | glycoprotein scaveng receptor cystein rich domain promot adhes staphylococcus aureus pseudomona aeruginosa contact len polym contact lens biomateri worn eye correct refract error bacteri adhes colon lens result advers event microbi kerat adsorpt tear protein contact len materi enhanc bacteri adhes glycoprotein gp tear compon known promot microbi colon oral caviti howev investig contact len relat advers event therefor studi examin adsorpt gp recombin express scaveng receptor cystein rich srcr gp domain two common contact len materi etafilcon lotrafilcon b concomit effect adher clinic isol microbi kerat causat agent pseudomona aeruginosa pa pa staphylococcus aureus sa usa across strain materi srcr gp enhanc adher bacteria dose depend manner howev srcr gp modul lysozym lactoferrin effect bacteri adhes contact len gp bind serin rich surfac protein srap signific enhanc bind usa srcr gp coat lens addit srcr gp coat surfac signific diminish biofilm srap mutant srap reduct biofilm sortas mutant srta indic like involv addit surfac protein final bind affin srcr gp srap determin use surfac plasmon reson spr complet srap bind region display nanomolar affin wherea smaller fragment adher micromolar affin studi conclud gp srcr domain play import role bacteri adhes contact len | D001422;D003261;D011108;D054730 | T116;T082;T123;T074;T104;T122;T040 |
34,662,198 | vitro suscept typhoid nontyphoid extend spectrum lactamas produc salmonella ceftolozanetazobactam typhoid nontyphoid salmonella includ top drug resist threat describ us center diseas control prevent urgent need look altern antibiot treatment salmonella infect use broth microdilut test examin vitro suscept typhoid nontyphoid salmonella includ isol posit extend spectrum lactamas esbl ceftolozanetazobactam six antibiot typhoid nontyphoid salmonella isol test suscept ceftolozanetazobactam base overal mic valu salmonella isol suscept ceftolozanetazobactam mgl compar agent ampicillin mgl levofloxacin mgl azithromycin mgl ceftriaxon mgl chloramphenicol mgl trimethoprimsulfamethoxazol mgl comparison activ antimicrobi agent nontyphoid salmonella isol accord serogroup show ceftolozanetazobactam highest activ salmonella serogroup g q isol wherea lowest activ observ serogroup e isol esbl produc salmonella isol nontyphoid ctx produc ctx produc sensit ceftolozanetazobactam albeit mic valu higher mgl non esbl produc mgl summari data indic ceftolozanetazobactam activ strain typhoid nontyphoid salmonella also esbl produc salmonella | D000900;D024881;D010397 | T032;T195;T121;T109 |
34,662,197 | linear regress equat predict lactam macrolid lincosamid fluoroquinolon mic molecular antimicrobi resist determin streptococcus pneumonia antimicrobi resist streptococcus pneumonia repres threat public health monitor dissemin resist strain essenti guid health polici multipl variabl linear regress model use determin contribut molecular antimicrobi resist determin antimicrobi mic penicillin ceftriaxon erythromycin clarithromycin clindamycin levofloxacin trimethoprim sulfamethoxazol train data set consist canadian pneumonia isol obtain use generat multipl variabl linear regress equat antimicrobi regress equat appli valid data set canadian n us n n isol mic lactam antimicrobi fulli explain amino acid substitut motif region penicillin bind protein pbpa ppbb pbpx accuraci predict mic within doubl dilut phenotyp determin mic penicillin ceftriaxon erythromycin clarithromycin clindamycin levofloxacin trimethoprim sulfamethoxazol overal sensit specif accuraci predict mic phenotyp determin mic similar phenotyp mic comparison studi abil acquir detail antimicrobi resist inform direct molecular determin facilit transit routin phenotyp test whole genom sequenc analysi fill surveil gap era increas relianc nucleic acid assay diagnost better monitor dynam pneumonia | D000900;D000890 | T195;T121 |
34,662,196 | analog marinopyrrol show enhanc observ vitro potenc acut toxoplasma gondii infect apicomplexan parasit toxoplasma gondii causat agent toxoplasmosi global distribut infect sever clinic consequ immunocompromis individu develop fetus avail treatment associ potenti sever advers effect marinopyrrol compound discov marin streptomyc speci previous found exhibit potent antimicrobi activ prompt interest explor efficaci toxoplasma gondii found marinopyrrol high potent anti toxoplasma molecul vitro maxim inhibitori concentr ic correspond higher potenc current standard care pyrimethamin howev addit serum led abrog potenc toxic human cell line observ yet applic marinopyrrol vivo lethal acut infect model facilit signific enhanc surviv dose mgkg test seri marinopyrrol analog rl rl rl demonstr signific increas potenc vitro ic valu rang fold increas relat pyrimethamin detect cytotox observ human foreskin fibroblast cytotox hepg cell rang correspond fold select parasit host cell analog addit show reduc sensit serum rl potent inhibit vitro generat bradyzoit taken togeth data support develop marinopyrrol analog promis anti toxoplasma molecul combat preval infect | D000981;D014122;D014123 | T204;T047;T121 |
34,662,195 | updat analysi surfac carbohydr gene cluster divers panel acinetobact baumannii isol enhanc util genet divers panel acinetobact baumannii isol report recent galac cowork r galac e snesrud f lebreton j stam et al antimicrob agent chemoth e https doiorgaac identifi novel kl ocl gene cluster direct biosynthesi capsular polysaccharid outer core lipooligosaccharid respect reexamin nine kl one ocl previous record novel identifi nine novel kl two ocl found | D040981 | T007 |
34,662,194 | appli cefepim popul pharmacokinet critic ill patient receiv continu renal replac therapi patient admit intens care unit icu may need continu renal replac therapi crrt due acut kidney injuri worsen under chronic kidney diseas affect antimicrobi exposur may signific impact treatment aim develop cefepim pharmacokinet pk model crrt icu patient generat posterior predict group assess therapi outcom adult patient admit icu receiv cefepim concentr measur crrt includ three differ data set two data set sampl collect predialyz postdialyz port effluent fluid differ time within dose interv third data set cefepim plasma concentr measur part clinic servic patient demograph cefepim regimen concentr crrt paramet therapi outcom record npag use popul pk posterior predict total patient includ cefepim describ five compart model crrt flow rate describ rate cefepim transfer compart posterior predict generat third data set median rang f mic f mic mortal rate differ target attain term clinic cure day mortal model use precis dose tool crrt patient futur studi may address pkpd target larger popul | D058186;D000079664 | T061;T047;T037 |
34,662,192 | metabol excret mass balanc c rezafungin anim human rezafungin novel echinocandin develop treatment candidemia invas candidiasi prevent invas fungal diseas caus candida aspergillus pneumocysti spp recipi blood marrow transplant studi use c radiolabel rezafungin conduct rat monkey human character mass balanc excret pharmacokinet c rezafungin evalu relat amount rezafungin metabolit compar parent drug fecal excret main rout elimin rat monkey human radioact primarili excret unchang drug averag total recoveri rat h monkey h human cumul recoveri radioact first day fece urin estim mean overal recoveri day fece urin clinic pharmacokinet rezafungin follow singl mg intraven infus ci c rezafungin similar plasma plasma total radioact whole blood total radioact unchang rezafungin repres major total radioact plasma partit total radioact red blood cell neglig across speci rezafungin primarili metabol hydroxyl terphenyl pentyl ether side chain excretionmass balanc metabol pk studi clinic observ consist find rat monkey demonstr minim metabol slow elimin rezafungin intraven administr fecal excret major rout elimin | D000935;D058365 | T195;T047;T121 |
34,662,191 | phage activ plankton biofilm staphylococcus aureus periprosthet joint infect isol recent report success treatment case periprosthet joint infect pji phage phage activ bacteria caus pji systemat evalu examin vitro activ seven phage clinic isol staphylococcus aureus recov april februari subject pji phage assess plankton biofilm phenotyp activ individu phage demonstr bacteri isol plankton state biofilm form isol plankton phage suscept suscept phage correl small coloni variant phenotyp plankton biofilm bacteria correl antibiot suscept plankton phage suscept biofilm phage suscept strength biofilm format note select condit result demonstr phage infect aureus caus pji plankton biofilm phenotyp thus worthi investig altern addit antibiot set | D001435;D016459;D013203 | T047;T046;T005 |
34,662,190 | secondari analysi systemat review antifung noninferior trial risk erod effect biocreep noninferior random control trial rct effect may erod result favor activ control time decreas effect control arm use serial trial analyz antifung noninferior rcts ni rcts scenario secondari analysi systemat review exploratori analysi suggest eros risk effect antifung noninferior trial uncommon find limit small sampl size overal risk bias | D000935 | T195;T121 |
34,662,188 | critic ill patient multidrug resist acinetobact baumannii respiratori infect success treat intraven nebul bacteriophag therapi hospit patient risk develop serious multidrug resist bacteri infect risk heighten patient mechan ventil immunocompromis andor chronic comorbid report case year old critic ill patient multidrug resist acinetobact baumannii mdr respiratori infect success treat antibiot intraven nebul bacteriophag therapi | D000151;D040981;D003428;D000071059;D012141 | T007;T047;T061 |
34,662,187 | role mprf mutat seesaw effect daptomycin resist methicillin resist staphylococcus aureus isol emerg daptomycin resist dap r staphylococcus aureus strain becom global problem point mutat mprf main caus daptomycin dap treatment failur howev impact specif point mutat methicillin resist aureus mrsa strain associ dap resist seesaw effect distinct beta lactam remain unclear studi use three seri clinic mrsa strain three distinct mutat mprf allel clone complex cc explor seesaw effect combin effect dap plus beta lactam construct mprf delet complement strain sa determin mprf sa mprf sl one novel mutat mprf idel within bifunct domain lead dap resist compar wild type mprf clone dap suscept dap strain three mprf mutat confer seesaw effect distinct beta lactam sa mprf strain mutat mprf idel sl alter cell surfac posit charg p suscept beta lactam increas signific dap r cc strain seesaw effect found associ distinct mutat mprf allel categori beta lactam synergist activ dap plus oxacillin detect dap r mrsa strain continu progress understand mechan restor suscept beta lactam antibiot mediat mprf mutat impact beta lactam combin therapi provid fundament insight treatment mrsa infect | D019881;D001426;D017576;D055624 | T116;T007;T123;T195;T126 |
34,662,186 | antifung therapi azol induc syndrom acquir appar mineralocorticoid excess literatur databas analysi aim estim risk vari antifung therapi azol caus syndrom acquir appar mineralocorticoid excess ame real world practic first conduct disproport analysi base data fda advers event report system faer databas character signal differ triazol relat ame second systemat review conduct clinic featur ame case report clinic practic describ faer databas identifi case triazol ame posaconazol ror ci itraconazol ror signific increas risk ame event fluconazol voriconazol isavuconazol affect mineralocorticoid excess target eighteen studi case rais evid ame follow posaconazol itraconazol treatment anoth case identifi analysi descript clinic featur faer databas averag age patient year year ame main occur patient posaconazol concentr gml mean gml rang gml less like occur level gml median time event onset week advers event occur within month posaconazol present studi support recent find posaconazol itraconazol three azol antifung investig associ ame effect dose depend allow dose de escal strategi substitut fluconazol isavuconazol voriconazol resolv advers effect | D000935;D043204 | T195;T047;T121 |
34,662,185 | pharmacokineticspharmacodynam caspofungin plasma periton fluid liver transplant recipi weaker diffus echinocandin periton fluid pf could promot candida resist isol aim studi analyz pharmacokinet pk pharmacodynam pd caspofungin plasma pf sampl liver transplant recipi liver transplant patient receiv caspofungin postop prophylaxi caspofungin concentr quantifi plasma pf sampl day data analyz use nonlinear mix effect model mont carlo simul area curv auc valu plasma pf simul three dose regimen probabl target attain ptas calcul use area unbound plasma concentr time curv h steadi state f auc mic ratio mic rang mgl patient includ monitor week candida colon candida infect twenti patient includ median daili dose caspofungin mgkg plasma n pf n concentr steadi state avail two compart model first order absorpt elimin describ two compart model first order absorpt elimin produc effect pkpd relationship plasma achiev pta mic rang mgl candida albican candida glabrata pf ptas optim mic mgl patient weigh kg three dose regimen among patient colon mic valu maxim concentr c max plasma pf pf concentr caspofungin low simul show ptas candida spp pf optim might suggest potenti risk resist | D001202;D016031 | T046;T031;T061 |
34,662,184 | potenc omadacyclin mycobacteroid abscessus clinic isol vitro mous model pulmonari infect incid nontubercul mycobacteri diseas unit state rise surpass tuberculosi notabl among nontubercul mycobacteria mycobacteroid abscessus emerg environment opportunist pathogen capabl caus chronic infect abscessus diseas difficult treat current treatment recommend includ repurpos antibiot sever associ undesir side effect studi evalu activ omadacyclin new tetracyclin deriv abscessus use vitro vivo approach omadacyclin exhibit mic gml panel contemporari abscessus clinic isol sever resist antibiot common use treatment abscessus diseas omadacyclin combin clarithromycin azithromycin cefdinir rifabutin linezolid also exhibit synerg sever abscessus strain exhibit antagon combin addit nine antibiot also common consid treat abscessus diseas concentr depend activ omadacyclin observ time kill assess efficaci omadacyclin evalu mous model lung infect four abscessus strain dose equival mg standard oral human dose use compar untreat control group within week treatment log fewer abscessus cfu observ lung mice treat omadacyclin treatment outcom biphas bactericid activ observ first week treatment four abscessus strain | D009165;D000073358 | T007;T047 |
34,662,183 | vitro activ ceftibutenvnrx urinari tract infect isol antimicrobi resist enterobacteral ceftibutenvnrx cephalosporinboron lactamas inhibitor combin develop oral treatment complic urinari tract infect caus enterobacteral produc serin lactamas ambler class c vivo vnrx vnrx etzadroxil cleav activ inhibitor vnrx assess vitro activ ceftibutenvnrx urinari isol enterobacteral global cultur collect isol test preselect possess multidrug resist mdr phenotyp includ nonsuscept amoxicillin clavulan resist levofloxacin mic determin clsi broth microdilut vnrx test fix concentr gml ceftibutenvnrx inhibit isol test mic gml mic esbl n serin carbapenemas n acquir ampc posit n isol subset gml respect concentr gml ceftibutenvnrx inhibit isol test esbl posit isol serin carbapenemas posit isol acquir ampc posit isol ceftibutenvnrx concentr gml inhibit isol suscept defin clsi eucast breakpoint criteria nitrofurantoin trimethoprim sulfamethoxazol andor fosfomycin part mdr phenotyp oral agent common prescrib treat uncompl urinari tract infect potenc ceftibutenvnrx mic gml similar within one doubl dilut intraven agent ceftazidim avibactam mic gml meropenem vaborbactam mic gml continu investig ceftibutenvnrx warrant | D000900;D014552 | T195;T047;T121 |
34,662,182 | evalu cap dose telavancin regimen compar standard dose larg communiti teach hospit telavancin lipoglycopeptid antibiot tradit dose mgkg base total bodi weight associ toxic limit use studi support use cap dose regimen mg obes patient associ equal efficaci fewer advers effect compar tradit dose | D000617;D000900 | T195;T121;T109 |
34,662,181 | efficaci acid oxid solut mycobacterium ulceran treatment chronic wound acid oxid solut aoss broad spectrum microbicid activ without disturb granul tissu format develop found aoss effici kill mycobacterium ulceran causat agent buruli ulcer abl surviv harsh decontamin treatment topic ao treatment buruli ulcer lesion may support recommend antibiot therapi oral rifampin clarithromycin prevent contamin environ mycobacteria control secondari infect preval wound manag problem resourc poor set buruli ulcer endem | D054312;D019911 | T007;T047 |
34,662,161 | social vulner prematur cardiovascular mortal among us counti substanti differ exist unit state counti regard prematur year age cardiovascular diseas cvd mortal whether under social vulner counti influenc prematur cvd mortal uncertain | D000091482 | T033 |
34,662,151 | identifi equit screen mammographi strategi black women unit state use simul model screen mammographi guidelin explicit consid racial differ breast cancer epidemiolog treatment surviv | D001741;D008327 | T060;T098 |
34,662,145 | pediatr cancer data common feder democrat data childhood cancer research intern pediatr oncolog communiti long histori research collabor unit state launch children cancer data initi put focus develop rich robust data ecosystem pediatr oncolog spirit present experi construct pediatr cancer data common pcdc highlight signific effort fight pediatr cancer improv outcom provid essenti inform creat resourc diseas area univers chicago pcdc team work intern research communiti sinc build data common children cancer identifi six critic featur success data common design implement establish need data common develop deploy technic infrastructur establish implement govern make data common platform easi intuit research social data common creat work knowledg expertis research communiti plan longev sustain data common critic conduct research larg patient cohort ultim lead improv outcom children cancer valu connect high qualiti clinic phenotyp data extern sourc data genom proteom imag data next step pcdc includ creat inform invest data share cultur develop sustain method data collect share standard genet biomark report incorpor radiolog molecular analysi data build model electron patient consent method process describ extend clinic area provid blueprint other wish develop similar resourc | D035843;D009369 | T062;T191 |
34,662,144 | genom assembl transcriptom colletotrichum sublineola csgl new resourc studi anthracnos diseas sorghum colletotrichum speci global distribut well known member destruct phytopathogen genus caus anthracnos diseas wide varieti crop fruit colletotrichum sublineola causal agent anthracnos diseas sorghum caus loss yield use pacbio sequenc combin rna seq generat chromosom level assembl annot colletotrichum sublineola strain csgl formula see text copyright author open access articl distribut cc nc nd intern licens | D020231;D045868 | T004;T002 |
34,662,142 | scaffold deep learn framework generat coordin drug like molecul desir scaffold prerequisit therapeut drug design discoveri identifi novel molecul develop lead candid desir biophys biochem properti deep generat model demonstr abil find molecul explor huge chemic space effici effect way generat new molecul desir target properti constrain critic fucntion group core scaffold generat process end develop domain awar generat framework call scaffold take coordin desir scaffold input generat coordin novel therapeut candid output alway preserv desir scaffold generat structur demonstr framework generat predomin valid uniqu novel experiment synthesiz molecul drug like properti similar molecul train set use domain specif data set generat coval noncoval antivir inhibitor target viral protein measur success framework generat therapeut candid generat structur subject high throughput virtual screen via dock simul show favor interact sar cov main proteas mpro nonstructur protein endoribonucleas nsp target import deep learn model perform well relat small structur train data quick learn general new scaffold highlight potenti applic domain generat target specif candid | D000086382;D000077321;D004364 | T047;T066;T121;T067 |
34,662,140 | hidden halogen bond abil fluorin manifest hydrogen bond configur hydrogen fluorid elucid intermolecular interact coval bond fluorin atom similar differ halogen atom help better unifi understand present studi case hydrogen fluorid theoret studi viewpoint use techniqu electron densiti analysi molecular dynam liquid other shown extra point model locat addit charg site line extend within coval bond adopt halogen bond system key generat proper stabil direct work well also case signific bent hydrogen bond configur characterist intermolecular interact hydrogen fluorid reason well reproduc mean manifest latent halogen bond abil hidden strong electroneg natur | D005461;D006219 | T196;T123 |
34,662,137 | hierarch color structur three dimension print invers opal structur color recur solut biolog system control visibl light natur basic structur color result light interact repetit nanopattern complex interact strike result achiev organ incorpor addit hierarch structur artifici reproduct singl level structur color achiev use repetit nanostructur flat sheet invers opal popular simpl reliabl fabric process control photon structur sever length scale use combin direct laser write nanospher assembl produc freeform hierarch construct invers opal high intens structur color report first print stack overhang slant microstructur invers opal among characterist hierarch photon structur exhibit geometr tunabl color focal plane depend pattern arbitrari align microstructur facet self assembl lattic base result novel concept multilevel inform encod system present | D049329;D017785 | T167;T073 |
34,662,134 | approach superfold thick limit carbon nanofib membran transform water solubl pva recent progress flexibl electron attract tremend attent howev still difficult prepar superfold conduct materi good biocompat high sens sensit larg specif surfac area expect biomimet method water solubl precursor like poli vinyl alcohol pva electrospin util solv problem inspir multistag water manag process spider spin draglin silk establish combin biomimet techniqu hydrocolloid electrospin coupl temperatur gradient dehydr carbon techniqu pva driven superfold carbon nanofib membran pva sfcnfms prepar possess micropor ratio g specif surfac area also withstand real fold cycl approach thick limit without structur fractur furthermor membran provid high sensit sens superior biocompat interfac molecular mechan improv carbon convers fold mechan obtain three level dispers stress pva sfcnfms propos | D057139;D011142 | T121;T122;T073;T109 |
34,662,130 | dna origami voltag sensor transmembran potenti singl molecul sensit signal transmiss neuron goe along chang transmembran potenti report differ approach includ optic voltag sens dye genet encod voltag indic evolv present dna nanotechnolog base system demonstr function liposom use dna origami incorpor optim differ properti membran target voltag sens modular sens unit use hydrophob red dye anchor membran anion green dye dna connect nanostructur membran dye anchor voltag induc displac anion donor unit read fluoresc reson energi transfer fret chang singl sensor attach liposom fret chang mv observ work mechan sensor ration molecular dynam simul approach hold potenti applic nongenet encod membran sensor | D031541;D036103 | T059;T090 |
34,662,128 | metal organ spin transistor organ molecul specif bio organ system attract applic due low cost variabl environment friendli facil manufactur bottom fashion howev due relat low conduct actual applic limit chiral metallo bio organ crystal hand improv conduct addit interest magnet properti develop spin transistor use crystal base chiral induc spin select effect devic featur memristor type behavior depend trap charg spin spin properti monitor hall signal extern magnet field spin transistor exhibit nonlinear drain sourc current multilevel control state generat magnet sourc vari sourc magnet enabl six level readout two termin devic simplic devic pave way technolog applic organ electron bioelectron | D004581;D008280 | T090 |
34,662,127 | bacteri biosynthet p enzym pikc dn potenti biocatalyst prepar human drug metabolit human drug metabolit hdms import chemic wide use drug relat studi howev acquir enzym deriv regio stereo select modifi compound chemic approach complic pikc biosynthet p enzym involv pikromycin biosynthesi bacterium streptomyc venezuela identifi mutant pikc dn potenti biocatalyst broad substrat scope diversifi product profil high catalyt effici prepar hdms remark pikc dn mediat drug metabol reaction use low cost h direct electron oxygen donor | D006861;D004364 | T130;T121;T197 |
34,662,126 | interfaci steric molecular bond effect contribut stabil neutral charg nanoemuls cosmet pharmaceut food applic mani activ ingredi limit bioavail aqueous environ context nanoemuls provid mechan encapsul protect transport dispers oil droplet order nanomet diamet owe long term stabil emulsifi common charg recent applic util nonion speci stabil agent due enhanc biosafeti dlvo name derjaguin landau verwey overbeek theori central descript colloid stabil emphas repuls electrostat forc extend dlvo theori also account steric effect past studi nanoemuls larg employ charg surfact polyelectrolyt make difficult decoupl electrostat steric effect relat droplet stabil better understand steric molecular factor contribut stabil uncharg droplet creat nanoemuls sodium dodecyl sulfat sds poli n vinylacetamid pnva though sds anion pnva coat droplet surfac potenti nanoemuls mv despit minim electrostat contribut nanoemuls stabl upward month interest dynam employ dynam light scatter vibrat sum frequenc scatter spectroscopi calcul interact pair potenti use extend dlvo theori learn thick pnva layer play critic role stabil uncharg nanoemuls beyond steric molecular conform pnva strand also contribut droplet stabil adsorb pnva strand shown form stratifi rigid polym network prevent nanoemuls rapid destabil | D045703;D013501 | T167;T120;T122 |
34,662,125 | imag autotaxin vivo f label positron emiss tomographi ligand autotaxin atx secret phosphodiesteras implic remark wide array patholog especi fibrosi cancer atx inhibitor enter clinic arena valid probe positron emiss tomographi pet current lack aim develop suitabl atx target pet radioligand synthes focus librari fluorin imidazo pyridin deriv determin inhibit constant confirm bind mode crystallograph analysi base promis vitro properti compound c f h j radiofluorin also deuter analog f j design f atx f design prove high stabl vivo radiodefluorin compar f c f f f h f j result along vitro vivo studi toward atx mous model lps induc liver injuri suggest f atx suitabl pet probe non invas quantif atx | D049268 | T060 |
34,662,123 | optic modul hfs base synaps artifici vision system simul human brain neuron synapt devic could effect strategi break notori von neumann bottleneck memori wall herein opto electron synaps base layer hafnium disulfid hfs transistor investig basic function biolog synaps realiz optim modifi puls light condit furthermor pixel imag chip also develop two pixel visual inform illumin diagon pixel imag array appli light puls nm differ puls frequenc mimick short term memori long term memori characterist human vision system addit opticallyelectr driven neuromorph comput demonstr machin learn classifi hand written number accuraci work import step toward artifici neural network compris neuromorph vision sens train function | D016571 | T170 |
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