PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,688,922 | examin associ amygdala volum anxieti symptom autism spectrum disord anxieti one common co occur condit peopl autism spectrum disord amygdala identifi associ anxieti popul without autism yet associ autism base relat small development constrain sampl leav question whether result hold differ development age larger robust sampl | D000067877 | T048 |
34,688,921 | matern error relat negat relationship offspr error relat negat negat parent style novel model intern psychopatholog risk enhanc error relat negat ern event relat potenti compon reflect neural sensit error threat theoriz repres endophenotyp intern psychopatholog ip test whether intergener transmiss ern pattern may confer risk intern symptom examin associ among matern offspr ern offspr intern symptom given role parent ip risk also explor matern negat parent style relat matern ern offspr intern symptom | D003865;D016487 | T048;T054 |
34,688,920 | matern immun activ hypothes human neurodevelop outstand question matern immun activ hypothesi lead model understand prenat influenc individu differ clinic syndrom neurodevelop experiment anim human research prolifer recent year sizabl research base sever meta analys demonstr general support associ prenat immun activ neurodevelop human research howev question remain natur immun activ network under mechan involv breadth impact across behavior phenotyp complement recent review result current review place particular emphasi better understand mechan may achiev greater attent address methodolog variat limit exist studi identifi area clinic research | D011297 | T037 |
34,688,919 | yeast express recombin sar cov receptor bind domain rbd n covid protein vaccin candid sar cov protein subunit vaccin current evalu multipl manufactur address global vaccin equiti gap need low cost easi scale safe effect covid vaccin paper report generat receptor bind domain rbd n yeast express construct produc recombin protein capabl elicit robust immun respons protect mice sar cov challeng infect rbd n antigen express yeast pichia pastori x ferment l scale protein purifi hydrophob interact chromatographi follow anion exchang chromatographi purifi protein character biophys biochem formul immunogen evalu mice sera evalu efficaci use sar cov pseudovirus assay rbd n protein express yield mgl ferment supernat two step purif process produc pure protein recoveri rate total yield purifi protein mgl ferment supernat protein character homogen monom show well defin secondari structur thermal stabl antigen adjuv alhydrogel presenc cpg immunogen induc high level neutral antibodi sar cov pseudovirus characterist rbd n protein base vaccin show candid anoth well suit rbd base construct technolog transfer manufactur entiti feasibl transit clinic evalu immunogen safeti human | D000086663;D015870;D000086402;D064370 | T116;T045;T123;T005;T200 |
34,688,918 | evalu efficaci immobil metal affin chromatographi imac host cell protein hcp remov anti scfv express escherichia coli host cell protein hcps process relat impur influenc product safeti efficaci hcps effect remov chromatograph step downstream purif process studi aim evalu efficaci immobil metal affin chromatographi imac separ hcps anti singl chain fragment variabl scfv express e coli studi explor differ purif condit includ nativ denatur hybrid affect hcp level purifi anti scfv furthermor effect nacl concentr wash buffer well imidazol concentr wash elut buffer purif yield hcp level purifi anti scfv evalu found increas imidazol concentr wash elut buffer nativ condit reduc yield anti scfv purif howev enhanc nacl concentr wash buffer purif nativ condit led signific increas amount anti scfv without chang protein puriti herein none imac purif method conduct solubl cytoplasm protein nativ condit could reduc amount hcp accept level hcp content lower ppm inclus bodi purifi hybrid condit furthermor increas imidazol concentr wash buffer purif hybrid condit led signific increas elut anti scfv concentr hcp content also increas condit overal purif hybrid condit use wash buffer contain mm imidazol result highest yield accept level hcp | D002846;D015870;D018719 | T116;T045;T192;T059;T126 |
34,688,917 | target white matter neuroprotect relaps prevent strategi treatment cocain use disord design mechan focus random clinic trial cocain use continu signific public health problem limit treatment option approv pharmacotherapi cognit behavior therapi cbt remain mainstay treatment prevent relaps howev peopl chronic cocain use display cognit impair associ poor respons cbt emerg evid anim human studi suggest peroxisom prolifer activ receptor gamma ppar agonist pioglitazon improv white matter integr essenti cognit function project determin whether adjunct use pioglitazon enhanc effect cbt prevent relaps earli phase recoveri cocain use disord paper describ design mechan focus phase random clinic trial aim first evalu effect pioglitazon target mechan relat white matter integr cognit function cocain crave second evalu extent improv target mechan predict cbt respons posit result support pioglitazon potenti cognit enhanc agent advanc later stage medic develop research | D003042;D066127 | T023;T121;T109;T131;T024 |
34,688,916 | pilot studi school lunchroom intervent predomin latinx sampl purpos studi assess feasibl environment school lunchroom intervent smarter lunchroom test initi efficaci within predomin latinx popul | D005522 | T095;T057 |
34,688,915 | design spine pain intervent enhanc care qualiti reduc expenditur trial spine care studi method lesson multi site pragmat cluster random control trial low back neck pain togeth spine pain among lead caus medic visit lost product disabl peopl episod spine pain self limit nevertheless healthcar spend condit extrem high focus care individu high risk progress acut chronic pain may improv effici altern postur therapi frequent use patient may prevent overus high cost intervent deliv equival outcom | D059350;D005102 | T047;T184;T081 |
34,688,913 | use comput eskap antibiot resist crisi sinc discoveri penicillin develop use antibiot promot safe effect control bacteri infect howev number antibiot resist case ever increas time thus drug discoveri process demand fast effici cost effect altern approach develop lead candid outstand perform comput approach appeal techniqu develop lead candid silico fashion review provid overview implement current silico state art techniqu includ machin learn ml deep learn dl drug discoveri also discuss develop quantum comput potenti benefit antibiot research current bottleneck limit comput drug discoveri advanc | D001185;D015195 | T066;T073;T090 |
34,688,912 | micro nanoformul paclitaxel base micell liposom cubosom lipid nanoparticl recent advanc challeng diterpenoid molecul paclitaxel ptx extract western yew tree taxus brevifolia promis anticanc drug specif clinic use ovarian breast cancer howev wider use hamper advers effect emerg resist cancer cell micell liposom cubosom lipid nanoparticl lnps potenti reduc even remov complic associ use ptx herein provid overview micro nanoformul ptx base micell liposom cubosom lnps improv therapeut effect drug vitro vivo | D053758;D017239 | T121;T073;T109 |
34,688,911 | toward institution quantum comput pharmaceut research innov pharmaceut compani start explor quantum comput qc articl provid collect industri perspect qc domain leader lead pharmaceut compani immedi nonfinanci benefit engag qc like financi return short term drug develop manufactur suppli chain potenti larg scientif benefit drug discoveri long term discuss requir activ institution qc creat understand qc among research manag deploy extern resourc identifi problem address qc deploy qc like similar trajectori comput aid drug design cadd artifici intellig ai respect | D000071220 | T062 |
34,688,908 | preval character clostridium perfringen isol differ chicken farm china clostridium perfringen c perfringen common pathogen microorgan present natur caus anim human diseas necrot enter ne poultri littl known current preval status c perfringen poultri farm differ type region china decemb august investig preval genotyp distribut drug resist c perfringen guangdong pingyin taian weifang total sampl collect process c perfringen isol among sampl determin posit c perfringen total isol c perfringen recov strain isol posit sampl isol identifi type other type f antimicrobi suscept test reveal isol resist least five class common use antibiot multilocus sequenc type mlst show repres isol divid sequenc type sts simpson divers index ds sts five farm isol classifi seven clonal complex cc cc isol farm concentr minimum span tree addit cloaca isol feed isol distribut st cc result indic c perfringen chicken come environ feed etc | D002645;D000072480 | T082;T083;T012 |
34,688,907 | character larg yellow croaker larimichthi crocea osteoprotegerin role innat immun respons vibrio alginolyticus osteoprotegerin opg member tumor necrosi factor receptor superfamili contribut inflamm apoptosi differenti howev function opg host immun system teleost remain unclear clone cdna lcopg gene larg yellow croaker lcopg mrna express analyz tissu upregul vibrio alginolyticus infect immun tissu monocytesmacrophag mom subsequ lcopg protein express purifi use prokaryot express system recombin lcopg protein rlcopg treatment suppress v alginolyticus induc pro inflammatori cytokin enhanc v alginolyticus induc anti inflammatori cytokin mrna express furthermor rlcopg decreas v alginolyticus induc mom apoptosi therefor result indic lcopg might play role immun respons v alginolyticus infect larg yellow croaker | D005393;D010473 | T013;T047 |
34,688,906 | identif express analysi thyroid stimul hormon subunit effect gonad differenti relat gene express rice field eel monopterus albus thyroid stimul hormon tsh import glycoprotein hypothalam pituitari thyroid axi play crucial role synthesi releas thyroid hormon vertebr rice field eel monopterus albus protogyn hermaphrodit fish undergo sex revers function femal male ideal model investig regul sex differenti studi obtain cdna sequenc thyroid stimul hormon subunit tsh rice field eel contain complet open read frame encod putat protein amino acid multipl align protein sequenc show tsh high conserv teleost tissu distribut indic tsh show high express pituitari moder express brain region gonad intestin liver low express peripher tissu natur sex revers express tsh signific differ pituitari compar ovari express tsh increas signific gonad late intersexu male stage treatment differ dose triiodothyronin gg gg gg bodi weight serum free triiodothyronin ft increas sharpli express tsh inhibit signific pituitari although signific effect level serum e stimul releas serum kt high dose group also detect effect express gonad differenti relat gene rice field eel treatment inhibit express foxl cypaa dax stimul express soxa result indic tsh may involv sex differenti ths may play role regul male develop sex revers rice field eel | D006066;D012733 | T040;T023 |
34,688,905 | asthma ambulatori care qualiti foreign born latino children unit state foreign born latino children unit state us poor asthma outcom role routin care util outcom unclear object compar select ambulatori care util measur asthma foreign born latino us born latino non hispan white children | D001249;D007251 | T047 |
34,688,904 | role neuroglia neuropath pain depress patient neuropath pain induc nerv injuri usual present co morbid affect chang depress neuroglia report play import role develop mainten neuropath pain central peripher meanwhil studi show neuroglia particip develop depress howev specif role neuroglia neuropath pain depress review comprehens therefor summar recent find role neuroglia neuropath pain depress base review found bridg like role neuroglia neuropath pain co morbid depress review may provid therapeut implic treatment neuropath pain offer potenti help studi mechan futur | D003863;D009437;D009457 | T025;T048;T047;T184 |
34,688,899 | eeg spectral properti medit mind wander differ experienc medit novic previous literatur suggest individu medit train becom less distract medit practic studi assess whether putat differ subject experi medit medit non medit reflect eeg spectral modul purpos record electroencephalographi eeg rest two breath focus medit without experi sampl group adult particip year medit experi control group particip without medit experi experi sampl one medit condit allow us disentangl period breath focus mind wander ie moment distract driven task irrelev thought medit practic overal medit report greater level focus reduc mind wander medit practic control line report eeg spectral modul associ medit mind wander also differ signific medit control medit control show signific decreas individu alpha frequenc amplitud steeper f slope medit relat rest control medit show relat increas individu alpha amplitud mind wander relat breath focus period togeth result show subject experi medit mind wander differ medit novic reflect oscillatori non oscillatori properti eeg | D001288;D004569;D019122 | T034;T060;T041 |
34,688,896 | brain negoti diverg execut process demand evid network reorgan fleet brain state perform everyday context multipl network draw share execut resourc maintain attent regul arous solv problem time requir attent self regul appear competit brain attempt resolv conflict aris diverg process demand demonstr brain capabl manag multipl process via rapid cycl function brain state time typic regard treat brain complex system compris relationship within function network implement hidden markov model hmm electroencephalograph eeg data identifi nonlinear brain state intra internetwork synchroni produc better perform women subject task solv difficult problem autobiograph relev evalu stress prior work often found emot regul default mode network ern dmn activ conflict frontopariet network fpn abil facilit execut function necessari problem solv contrast discov fleet nonlinear state domin fpn ern internetwork synchroni support optimum perform general stress state domin ern dmn intranetwork synchroni import perform result impli brain may capabl resolv compet process network cooper dynam data suggest novel role dmn mechan integr extern threat intern self refer process evalu stress within observ popul | D004569;D008433 | T090;T034;T060 |
34,688,895 | cd express hematopoiet neoplasm beyond marker diagnosi b cell neoplasm cd ox express myeloid cell b cell subset cell normal neoplast non hematopoiet cell interact cdr suppress effect cell immun mediat respons aim review cd express role immun evas non b cell hematopoiet neoplasm acut myeloid leukemia cd seem relat worst outcom even diseas good prognosi possibl due immunosuppress effect plasma cell myeloma studi associ cd express worst prognosi possibl due suppress effect monocyt cell mediat immun respons other cd appear marker better outcom even show impact event free surviv ef studi evalu cd express cell neoplasm howev appear good immunophenotyp marker angioimmunoblast cell lymphoma conclus cd appear involv immun evas malign cell could affect surviv patient | D019337;D016393;D009101 | T191 |
34,688,894 | thorac irradi conform advanc techniqu systemat review treatment safeti irradi studi group italian associ radiat oncolog airo irradi rt treatment modal activ investig recurr lung cancer lung metastas appear previous irradi area literatur search accord prisma recommend meta analysi techniqu perform aim identifi possibl factor relat toxic incid sever g acut toxic patient studi met inclus criteria result show differ g acut toxic rate respect differ radiat techniqu cumul dose irradi total dose fraction factor eventu relat sever toxic describ frequent lack suffici descript treatment intent heterogen techniqu radiotherapi regimen make balanc risk benefit rt base publish data even difficult | D000069475 | T061 |
34,688,890 | pneumococc pneumonia among shipyard worker insid featur diseas onset sever outbreak pneumococc pneumonia among shipyard worker describ studi follow previous report group case aim elucid featur diseas onset | D011008;D011018 | T047 |
34,688,889 | hospit admiss refuge asylum seeker undocu migrant ten year retrospect studi worldwid popul forcibl displac peopl increas past decad approach million encompass million refuge asylum seeker research refuge migrant health remain scarc howev | D012036;D014171 | T098 |
34,688,888 | morpholog genet character phylogeni aplectana dayaoshanensi n sp nematoda ascaridida frog cosmocercoid nematod common parasit digest tract amphibian howev knowledg speci divers genet data molecular phylogeni superfamili cosmocercoidea far well understood present studi larg number cosmocercoid nematod collect fine spine frog sylvirana spinulosa smith anura ranida white spot thigh tree frog polyped megacephalus hallowel anura rhacophorida guangxi provinc china integr morpholog genet evid reveal nematod specimen new speci genus aplectana dayaoshanensi n sp cosmocercoidea cosmocercida molecular character small ribosom dna intern transcrib spacer larg ribosom dna dayaoshanensi n sp togeth chamaeleoni bayli collect hyperolius kivuensi ahl rwanda report first time moreov phylogenet analys use maximum likelihood ml infer base sequenc data respect support famili cosmocercida monophylet group famili kathlaniida paraphylet group phylogenet result reject monophyli genus aplectana present result contribut knowledg speci divers genet data cosmocercoid nematod preliminarili reveal phylogenet relationship major famili genera cosmocercoidea | D001001 | T011 |
34,688,887 | age impair fibrosi index sustain virolog respons direct act antivir chronic hepat c infect sustain virolog respons svr achiev case c type liver diseas direct act antivir daa therapi although liver fibrosi improv degre improv differ studi aim analyz factor involv improv liver fibrosi use fibrosi fib index | D000375;D016174;D000072230 | T040;T033;T005 |
34,688,886 | italica consortium multicentr collabor help shape manag patient hepatocellular carcinoma basi real world evid grow diffus digitalis informat promot creation analysi larg databas abl provid solid inform analys big data generat real world practic particular use know incid mortal dispar tempor trend diseas identifi risk factor predict futur scenario obtain input cost effect treatment benefit model design new studi monitor rare diseas although randomis control trial rcts repres gold standard generat evid new diagnost prevent therapeut procedur result integr real world data personalis patient manag inde substanti proport patient observ field practic characterist prevent access rcts includ form sub group small provid robust post hoc analys furthermor rcts resourc consum design maxim probabl success general perform expert centr high incom area exclud econom depriv region could complementarili contribut medic progress huge sourc real world data consider fuell creation italian liver cancer italica consortium aim merg data patient hepatocellular carcinoma hcc manag sever centr cooper permit analys multicentr larg cohort hcc patient sinc italica group progress expand current includ centr databas count patient articl describ histori italica consortium present scientif product whose result great contribut incess improv hcc manag | D006528;D008113 | T191 |
34,688,885 | impact hygrophila auriculata supplementari diet growth surviv biochem haematolog paramet fingerl freshwat fish cirrhinus mrigala hamilton present studi investig effect supplementari diet hygrophila auriculata growth surviv biochem haematolog paramet cirrhinus mrigala seawe administ fish possess initi averag weight g fish fed supplementari diet h auriculata exhibit signific differ p growth perform haematolog indic rbc count haematocrit volum haemoglobin wbc mcv mch mchc concentr contrast control period week also signific differ biochem paramet p fish supplement dietari h auriculata extract control group find suggest administr h auriculata extract posit effect immunolog indic immun system activ mrigal fish | D000821;D004032 | T168 |
34,688,884 | elimin giardia duodenali biv vivo use natur extract microbiom dietari supplement studi combin therapi sever natur product evalu vivo giardia duodenali infect model g duodenali infect mice treat follow distil water infect control c biointestil bio natur product cymbopogon martinii zingib officinal microbiomex mbx extract citrus sinensi citrus paradisi mbx bio camellia sinensi tea cpr black tea natur compound administ dose mgday compar g duodenali infect mice treat albendazol alb mgkgday metronidazol met mgkgday convent therapi use day one group remain un infect untreat control group c treatment start day infect day treatment day met anim follow day continu check presenc g duodenali faust method associ detect parasit pcr fece well presenc trophozoit intestin mucosa sacrific anim treat mbx bio mbx bio present undetect parasit load th day monitor anim treat cpr met alb continu releas cyst anim mbx mbx bio alb group consum lower feed mbx cpr met greater weight mbx mbx bio bio cpr c consum water compar infect group control mbx bio alon associ elimin g duodenali without appar advers effect anim group show better clinic perform relat high parasit load met alb cpr decreas number cyst indic limit therapeut failur | D064307 | T032;T001;T028 |
34,688,882 | prospect multi centric studi analyz pre transplant compat algorithm live relat donor kidney transplant indian set delhi approach sinc singl test alway accur sensit two test use increas precis evalu differ algorithm propos center leiden basel vienna minnesota etc intent develop optim algorithm india evalu pre transplant compat test live donor kidney transplant three test complement depend cyto toxic cross match cdcxm flow cytometri cross match fcxm anti hla antibodi screen perform confirm anti hla antibodi identif hai assay multi centric trial three transplant center india | D016030 | T061 |
34,688,881 | perceiv bodi imag distress liver tansplant recipi studi aim determin relationship percept self bodi imag level distress patient liver transplant surgeri | D001828;D066027 | T080;T101;T041 |
34,688,880 | reconstruct recycl nonauxotroph biosynthet pathway escherichia coli toward high effici product l citrullin l citrullin high valu amino acid promis applic medicin food industri construct high effici microbi cell factori l citrullin product still open issu due complex metabol flux distribut l arginin auxotrophi studi construct nonauxotroph cell factori escherichia coli high titer l citrullin product coupl modular engin strategi dynam pathway regul first biosynthet pathway l citrullin enhanc blockag degrad pathway introduct heterolog biosynthet gene corynebacterium glutamicum specif superior recycl biosynthet pathway design replac nativ linear pathway delet nativ acetylornithin deacetylas next carbamoyl phosphat l glutam biosynthet modul nadph generat modul efflux modul modifi increas l citrullin titer final toggl switch respond cell densiti design dynam control express argg gene reconstruct nonauxotroph pathway without extra supplement l arginin ferment final cit strain produc gl l citrullin l bioreactor yield gg glucos product g l h highest valu report microbi ferment studi demonstr success design cell factori high level l citrullin product also provid refer coupl ration modul engin strategi dynam regul strategi produc high valu intermedi metabolit | D053898;D048230 | T044;T007 |
34,688,879 | popul connect across high fragment distribut phylogeographi chalcophap dove chalcophap morpholog conserv genus ground walk dove distribut india mainland china south australia across western pacif vanuatu reconstruct evolutionari histori genus use dna sequenc data two nuclear gene one mitochondri gene sampl throughout geograph rang chalcophap find support three major evolutionari lineag phylogenet reconstruct correspond three current recogn chalcophap speci despit general concord identifi discord mitochondri nuclear ancestri subspeci c longirostri timorensi rais question evolutionari histori timor endem popul within three speci find evid isol distanc hierarch popul structur indic import role geographi diversif genus despit distribut broad across high fragment geograph region known hotspot avian diversif chalcophap dove show modest level phenotyp genet divers pattern potenti explain strong popul connect owe high overwat dispers capabl | D010856;D004272 | T123;T114;T012 |
34,688,878 | distribut seven apoc iii glycoform plasma vldl idl ldl hdl healthi subject glycosyl apoc iii modul function tg metabol variant associ atherogen lipid profil associ studi whole plasma rare individu lipoprotein fraction studi aim measur relat content apoc iii glycoform lipoprotein fraction potenti biomark tg metabol cardiovascular risk lipoprotein fraction separ differenti ultracentrifug plasma sampl healthi subject relat concentr seven apoc iii variant measur msia apoc iii apoc iii b apoc iii abund glycoform high interindividu variabl distribut glycoform across studi popul uniform proport lipoprotein fraction given subject two apoc iii variant apoc iii b apoc iii negat correl plasma vldl triglycerid irrespect vldl size associ increas ldl size transport ldl particl apoc iii b also show negat correl lipoprotein insulin resist score abl measur seven apoc iii glycoform lipoprotein fraction set basi futur studi explor role cardiovascular risk glycoform suggest less proatherogen role tg lipoprotein metabol signific apo ciii import role plasma tg metabol differ mechan also involv type type diabet mellitus differ glycosyl form apo ciii exist show differ role reason protein gain interest las year relationship apoc iii glycoform lipid lipoprotein metabol disord increas studi last year apo ciii glycoform previous analys plasma function main four glycoform assess varieti cohort present studi apoc iii glycoform measur lipoprotein fraction may clinic interest | D003924 | T047 |
34,688,877 | feasibl ultrasound guid insert peripher insert central cathet picc vascular surgeon bedsid trauma intens care unit studi analyz outcom ultrasound guid insert peripher insert central venous cathet picc experienc vascular surgeon bedsid trauma intens care unit icu compar outcom fluoroscopi guid picc perform radiologist intervent suit | D007362;D018084 | T060;T093;T073 |
34,688,875 | associ skelet muscl cardiovascular risk factor patient lower extrem arteri diseas sarcopenia defin low muscl mass low muscl strength low physic perform skelet muscl mass densiti strength invers associ cardiovascular risk factor aim determin relationship skelet muscl characterist strength mass area cardiovascular risk factor popul lower extrem arteri diseas lead | D000082742 | T033;T080 |
34,688,874 | vascular surgeri curriculum medic student nation target need assess present neither american colleg surgeon ac societi vascular surgeri svs provid curriculum recommend medic student rotat vascular surgeri servic sent target need assess vascular surgeon across countri order investig need structur curriculum medic student particip vascular surgeri rotat clinic clerkship | D002982;D004504;D020380;D013337 | T058;T065;T097 |
34,688,872 | risk factor intraop manag intoler flow revers tcar patient deem high risk carotid endarterectomi cea indic treatment carotid arteri stenosi cas transcarotid arteri revascular tcar demonstr safe effect altern tran femor carotid arteri stent tf cas compar cea approx patient undergo awak intervent toler intern carotid arteri ica clamp patient observ intoler flow revers tcar base data roadster trial studi review awak intervent trial assess factor associ intoler flow revers review case manag | D006439;D007430;D014656 | T058;T042;T061 |
34,688,871 | one step derivat dispers liquid liquid microextract hydroxychloroquin sulfat sensit accur determin use gc ms present studi novel analyt method determin hydroxychloroquin sulfat human serum urin sampl establish one step derivat dispers liquid liquid microextract dllme develop quantit determin hydroxychloroquin sulfat aqueous sampl hydroxychloroquin sulfat first hydrolyz convert benzoat deriv ad benzoyl chlorid chloroform also serv extract solvent signific paramet typevolum extract dispers solvent concentrationvolum sodium hydroxid typeperiod mix concentr derivat agent care optim one variabl time approach optimum dllme condit limit detect lod quantit loq dynam rang calcul gkg ppb respect recoveri studi conduct spike human serum urin sampl result rang low standard deviat develop method easili use hydroxychloroquin sulfat base sar cov malaria treatment studi | D000086382;D059627 | T047;T059;T067 |
34,688,870 | craniopharyngioma craniopharyngioma rare epitheli tumour situat primarili sellarparasellar region occur along path craniopharyng duct whilst class histolog benign tumour unpredict growth pattern proxim vital structur includ optic chiasm hypothalamus pituitari gland render consider threat signific associ morbid increas mortal occur child adulthood clinic manifest broad common symptomssign secondari hypothalam pituitari dysfunct rais intracrani pressur visual compromis two distinct histolog subtyp adamantinomat papillari uniqu pattern age distribut genet molecular make increas understand genet pathogenesi includ braf mutat papillari subtyp catenin mutat adamantinomat research provid hope discoveri target medic therapi exploit molecular chang occur result alter primari treatment consist surgeri without radiotherapi intracyst aspir chemotherapi irradi altern option select patient long term manag experienc multidisciplinari team essenti given breadth complic includ hypothalam morbid visual compromis cognit neuropsycholog sequela impair qualiti life | D003397;D010911 | T191 |
34,688,869 | complementari integr medicin academ health educ analyz academ educ complementari integr medicin cim accord univers student health area | D000529;D055048 | T091;T061 |
34,688,864 | ophiopogon japonicus inhibit white spot syndrom virus prolifer vivo enhanc immun respons chines mitten crab eriocheir sinensi white spot syndrom virus wssv fatal pathogen threaten global crustacean industri commerci avail drug control herbal medicin wide use treat number viral infect could offer rich reserv antivir drug discoveri evalu inhibit activ herbal medicin wssv chines mitten crab eriocheir sinensi wssv infect model e sinensi first establish order determin antivir effect plant extract explor potenti action mechan result show highest anti wssv activ obtain treatment ophiopogon japonicus extract mgkg japonicus treatment decreas viral load dose depend manner signific improv surviv wssv challeng crab japonicus reduc express vital gene viral life cycl vivo particular immedi earli stage gene ie result indic japonicus could repress jak stat signal pathway block ie transcript moreov japonicus could modul certain immun gene myosin toll like receptor crustin prophenoloxidas interact wssv crab regul express pro autophag factor gabarap atg elev level antioxid enzym sod cat gsh suggest japonicus may induc autophagi attenu wssv induc oxid stress taken togeth japonicus could inhibit wssv prolifer improv surviv wssv challeng crab thus japonicus may potenti develop prevent therapeut agent wssv effect compound merit isol identif | D031441;D046848 | T002;T005 |
34,688,863 | influenc bamboo vinegar powder bvp enrich diet antioxid status immun level pro anti inflammatori cytokin modul asian sea bass late calcarif bloch vibrio anguillarum effect bamboo vinegar powder bvp growth immun diseas resist immun relat gene express juvenil asian sea bass barramundi late calcarif vibrio anguillarum investig v anguillarum infect fish fed g bvp kg diet exhibit signific growth albumin ab serum total protein tp globulin gb level similar enhanc lysozym lzm phagocyt pc anti proteas ap respiratori burst rb bactericid bc activ total immunoglobulin ig level observ fish fed g bvp kg addit use g bvp kg diet modul sever immun relat gene express vibrio diseas studi exhibit posit effect dietari g bvp kg diet hemato biochem immunolog respons enhanc immunocompet health status l calcarif v anguillarum infect | D001492;D005393;D010473;D014733;D014735 | T013;T047;T007 |
34,688,862 | effect glutamin ikkibnf b system enterocyt turbot scophthalmus maximus l stimul soya saponin soya saponin repres key anti nutrit factor contribut soybean meal induc enter glutamin effect fish intestin protect combat negat effect soya saponin nuclear transcript factor kappa b nf b system involv interact soya saponin glutamin goal present work clarifi relat molecular mechan use nf b kinas ikk inhibitor nf b ib nf b system primari cultur turbot scophthalmus maximus l intestin epitheli cell concurr administr mgml soya saponin sever level glutamin mm h subject real time pcr western blot assay compar cell treat soya saponin alon glutamin signific decreas express interleukin beta interleukin tumor necrosi factor gene signific reduc nuclear cytosol nf b p abund level dose depend manner increas ib protein level decreas phosphoryl regul ikk phosphoryl ikk level conclus vitro work confirm glutamin attenu soya saponin induc inflammatori respons turbot intestin moreov identifi molecular pathway glutamin first decreas p level prevent nuclear transloc addit glutamin reduc ib phosphoryl maintain level final glutamin decreas ikk express phosphoryl | D005412;D012503 | T013;T109 |
34,688,860 | tobacco smoke exposur fraction exhal nitric oxid level among us adolesc fraction exhal nitric oxid feno object guid clinic practic assess diagnosi treatment eosinophil airway inflamm feno valu may affect current smoke role tobacco smoke exposur tse understudi | D014028 | T033;T069 |
34,688,859 | metal organ framework promot high solid enzymat hydrolysi untreat corncob residu metal organ framework mof could serv effici matrix immobil cellulas high stabil porous morpholog herein zr base mof uio uio nh assist wt high solid hydrolysi untreat corncob residu crs low enzym load investig glucan hydrolysi yield increas separ ad gl uio uio nh fpug glucan cellulas dosag maximum hydrolysi yield reach fpug glucan presenc gl uio nh analysi free protein concentr cellulas activ suggest mof effect increas cellulas catalyt activ stabil thus boost crs enzymat hydrolysi effici addit uio nh immobil gave high catalyt activ abund anchor site nh group research present promis futur mof applic lignocellulos biomass bioconvers area requir immobil enzym | D002480;D000073396 | T116;T121;T126;T109 |
34,688,858 | nitrogen remov two strain aerob denitrif actinomycet denitrif capac carbon sourc metabol abil raw water treatment denitrif characterist actinomyet aquat ecosystem aerob condit well known two actinomyet strain separ annot streptomyc sp strain could reduc total nitrogen total organ carbon aerob condit nitrogen balanc analysi indic nitrogen translat gaseous nitrogen assimil biomass strain highest remov effici nitrat strain micro pollut water bodi respect moreov strain exhibit remark carbon metabol capac especi ester altogeth studi provid new perspect understand perform actinomyet aerob denitrif micro pollut water repar | D039903;D018508 | T052;T007;T057 |
34,688,857 | suicid prevent asian american youth articl drs meza bath discuss need cultur adapt suicid prevent effort mitig rise adolescentyoung adult suicid rate across multipl racial ethnic background agre author care consider cultur valu linguist context socioeconom status crucial equit suicid prevent measur would like briefli spotlight mental health asian american youth bring attent recogn need divers popul | D001213;D013405 | T033;T098 |
34,688,856 | editori grow high stigma context unseen driver neurodevelop health patholog grow research establish stigma play key role drive popul health inequ particular among minor group inde stigma relat gender raceethn sexual orient mental ill disabl link elev risk mental physic health problem rang depress cardiovascular diseas recent neuroimag studi point chang brain structur function particular stress respons brain network mediat link stigma risk mental disord exampl recent neuroimag research link racial discrimin elev neural respons threat black women unit state import stigma occur multipl level research date focus stigma experienc individu interperson level eg ident conceal victim howev structur stigma eg law social norm increas recogn critic social determin health peopl margin group howev structur stigma methodolog challeng studi level neurobiolog relat larg multisit studi need span differ sociopolit context innov studi hatzenbuehl et al issu journal examin first time impact structur stigma neurodevelop children studi pave way futur studi examin context particular stigmat context act unseen driver neurodevelop health patholog | D001523;D057545 | T033;T048 |
34,688,854 | sex specif effect social isol stress ketamin hippocamp plastic chronic social isol stress sis induc last negat effect brain includ memori deficit cognit impair mood alter depress anxieti symptom least part reflect reduc hippocamp function clinic preclin studi subanesthet dose nmda receptor antagonist ketamin ket shown rapid last antidepress effect anim studi shown biolog sex level gonad hormon alter behavior effect ket ovarian hormon increas sensit antidepress like effect ket sinc hippocampus play key role mediat effect sis consid ket low dose shown rescu behavior deficit isol rear studi aim assess effect isol stress pre post synapt hippocamp function male femal rat rear sis well determin whether physiolog deficit rescu singl inject sub anesthet dose ket spragu dawley rat rais wean either social isol sex cage mate week male femal rat either diestrus proestrus receiv singl inject ket mgkg three hour prior termin collect acut hippocamp slice ex vivo electrophysiolog field potenti record long term potenti ltp pair puls facilit ppf output assess canon ca ca dorsal hippocamp circuit data show sis inhibit hippocamp ltp without affect ppf male rat effect rescu ket femal rat isol stress alter ltp reduc ppf especi femal test diestrus effect rescu ket highest dose data thus suggest sex differ contribut pre postsynapt hippocamp compart respons stress ket | D012727 | T032 |
34,688,853 | infect endocard caus staphylococcus aureus transcathet aortic valv replac staphylococcus aureus sa extens studi causat microorgan surgic prosthet valv infect endocard ie howev scarc evid exist sa ie transcathet aortic valv replac tavr | D012042 | T170 |
34,688,851 | comput tomographi protocol evalu coronari arteri diseas transcathet aortic valv replac transcathet aortic valv replac tavr comput tomograph angiographi cta imag use evalu coronari arteri diseas cad | D065467 | T061 |
34,688,850 | global metabol regul vibrio parahaemolyticus polymyxin b stimul vibrio parahaemolyticus respons infect diseas peopl consum contamin seafood metabol regul profil respons colistin last treatment option multidrug resist gram negat bacteria remain unclear studi metabol regul profil v parahaemolyticus atcc polymyxin b stimul investig v parahaemolyticus expos polymyxin b result differenti transcrib gene includ signific regul gene signific regul gene v parahaemolyticus polymyxin b stimul cellular antioxid system prevent bacteria oxid stress activ synthesi nonessenti macromolecul reduc assembl modif lipopolysaccharid peptidoglycan resist attack antibiot promot find provid new insight polymyxin b relat stress respons v parahaemolyticus use develop novel drug infect | D000900;D011112;D014736 | T195;T007;T121;T116 |
34,688,849 | effici develop sorafenib tablet improv oral bioavail enabl coprecipit amorph solid dispers amorph solid dispers asd sorafenib sor hydroxypropyl methylcellulos acet succin hpmc prepar coprecipit use develop immedi releas tablet improv oral bioavail asd drug load hpmc grade exhibit superior physic stabil enhanc dissolut select tablet develop systemat character powder properti asd led choic dri granul process overcom poor flowabl asd design tablet formul evalu use materi spare expedit approach optim compact condit manufactur asd tablet low friabil rapid disintegr result sor asd tablet exhibit approxim higher relat bioavail dog market sor tablet product nexavar | D001682 | T081 |
34,688,848 | isotretinoin delonix polymer nanoparticl potenti skin follicular target acn treatment acn manag oral isotretinoin ist associ various untoward system effect topic formul irrit side effect delonix dlx natur galactomannan deriv delonix regia seed fabric nanoparticl topic skin deliveri studi aim develop ist dlx nanoparticl assess prospect acn treatment fluoresc dlx nanoparticl made lipophil bodipi dye ist dlx nanoparticl prepar character bodipi dlx nanoparticl skin distribut ist dlx nanoparticl vitro target assess pig ear skin inflammatori modul assess amj macrophag cell skin penetr irrit assess wistar rat ist dlx nanoparticl nm negat zeta potenti encapsul effici confoc show bodipi dlx nanoparticl accumul hair follicl compar bodipi solut ist dlx nanoparticl releas ist h increas ist fold hair follicl compar ist solut ist dlx nanoparticl suppress il express cell reduc photo irrit wistar rat compar ist solut conclus ist dlx nanoparticl may target deliv adequ ist skin layer associ acn avoid system penetr modul inflammatori pathogen acn stage prevent ist topic photo irrit | D000152;D007887;D053758 | T047;T002;T073 |
34,688,847 | rf puls design optim reduc field view imag two dimension spatial select radiofrequ drf excit puls wide use reduc field view fov target high resolut diffus weight imag dwi especi anatom small region spinal cord prostat reduct fov achiev drf puls signific improv plane reson artifact singl shot echo planar imag ss epi howev long durat drf puls creat sensit plane reson effect especi reson field doubl respect work propos paramet base optim approach design drf puls blip along slice select axi goal maxim slab sharp minim reson effect mri scanner separ extens bloch simul perform evalu reson robust drf puls three differ metric propos quantifi similar actual ideal excit profil base signal within outsid target reduc fov region addit simul digit brain phantom perform visual comparison purpos result show maintain sharp profil primari design requir necessit usag relat high slab sharp time bandwidth product tbw around contrast reson robust primari design requir requir usag moder slap sharp tbw around | D038524;D017352 | T060 |
34,688,846 | carotid arteri wall mri apolipoprotein e defici mous use dant prepar variabl flip angl rapid acquisit relax enhanc optim sequenc combin delay altern nutat tailor excit dant prepar modul variabl flip angl rapid acquisit relax enhanc vf rare sequenc dant vf rare investig feasibl vessel wall imag apolipoprotein e defici apo mous tesla | D001057;D002339;D018810 | T116;T023;T060;T123 |
34,688,843 | experiment challeng model prostat cancer heterogen tumor heterogen play key role prostat cancer prognosi therapi select relaps acquisit treatment resist prostat cancer present heterogen divers inter intra tumor inter patient level influenc multipl intrins andor extrins factor recent studi start character complex prostat tumor differ tier heterogen review discuss common factor contribut tumor divers moreov focus descript vitro vivo approach well high throughput technolog help model intra tumor divers understand tumor heterogen challeng present guid enhanc patient risk stratif aid design precis therapi ultim help beat chameleon like diseas | D018740 | T032 |
34,688,838 | genotox impact aluminum contain nanomateri human intestin hepat cell exposur consum aluminum contain nanomateri al nms area concern public health agenc avail data genotox al al nms inconclus rare present studi investig vitro genotox potenti intestin liver cell model compar ionic form alcl intestin caco hepat heparg cell expos al al nms gcm cytotox oxid stress apoptosi measur use high content analysi genotox investig hax label alkalin comet micronucleus assay moreov oxid dna damag carcinogen properti assess use fpg modifi comet assay cell transform assay bhas cell respect three form al induc chromosom damag howev although product oxid stress detect al nms induc oxid dna damag caco cell like relat ion releas cell media consider dna damag observ al nms cell line comet assay like due interfer nms genotox effect observ alcl none al compound induc cytotox apoptosi hax cell transform | D004249 | T049 |
34,688,837 | cfu assay histor singl cell assay offer modern insight clonal hematopoiesi hematopoiet stem cell hscs studi extens sinc initi function descript dr jame till dr ernest mcculloch develop first vivo clonal strategi term spleen coloni form unit cfu assay assess function capac bone marrow deriv hematopoiet progenitor singl cell level transplant bone marrow cell analysi result cellular nodul spleen cfu assay reveal self renew clonal differenti capac hematopoiet progenitor develop use assay identifi high prolif self renew differenti hscs possess clonal multilineag differenti cfu strategi also adapt interrog singl purifi hematopoiet stem progenitor cell popul advanc knowledg hematopoiet hierarchi review explor major discoveri made cfu assay consid modern use recent improv compar common use long term transplant assay determin continu valu cfu assay understand hsc biolog hematopoiesi | D000082182 | T033;T047 |
34,688,836 | high fat diet aggrav coliti associ carcinogenesi evad ferroptosi er stress mediat pathway ferroptosi type program cell death caus lipid peroxid recent observ coliti whether high fat diet hfd affect ferroptosi whether contribut coliti associ carcinogenesi cac explor found iron lipid peroxid ferroptot marker elev aomdss azoxymethanedextran sulfat sodium induc mous cac model transmiss electron microscopi also confirm occurr ferroptosi colon tissu treatment ferroptosi inhibitor ferrostatin increas incid cac compar iso calor control mice hfd mice exhibit increas tumor number higher degre dysplasia follow repress lipid peroxid ferroptosi marker express mous colon tissu furthermor ferroptosi marker negat correl tumor number mice vitro lipid mixtur block ferroptosi various colorect cancer cell line inhibit gsh degrad negat regul chac target er stress signal final ferroptosi induc part abolish pro tumor effect hfd cac vivo collect find suggest hfd aggrav cac evas ferroptosi er stress mediat pathway provid new perspect cac prevent futur | D003092;D000079403 | T043;T047 |
34,688,833 | r ketamin amelior progress experiment autoimmun encephalomyel mice multipl sclerosi ms immun mediat neurolog diseas attack central nervous system includ spinal cord brain experiment autoimmun encephalomyel eae common use model ms depress preval comorbid ms patient previous demonstr r ketamin would novel antidepress without side effect ketamin studi undertaken investig whether r ketamin could attenu diseas progress eae mous model r ketamin mgkgday day signific attenu reduct bodi weight eae model mice compar salin treat mice furthermor r ketamin amelior clinic eae score compar salin treat mice moreov r ketamin signific attenu mark increas patholog score microgli activ blood brain barrier integr spinal cord compar salin treat mice conclus current studi suggest r ketamin could amelior eae clinic score patholog chang spinal cord eae mice therefor like r ketamin would new potenti prophylact drug ms | D004681;D007649;D009103 | T047;T050;T121;T109 |
34,688,832 | anti inflammatori antioxid effect astaxanthin follow spinal cord injuri rat anim model spinal cord injuri sci sever debilit problem lead substanti decreas qualiti life spinal cord injuri inflamm oxid stress play key role initi secondari injuri cascad lead progress tissu degrad extrem function deficit given primari mechan injuri spinal cord rare repair pharmacolog intervent may improv neurolog outcom caus secondari injuri astaxanthin ast consid xanthophyl carotenoid potent antioxid anti inflammatori properti various pharmacolog activ present studi aim first assess protect effect ast defin ast mechan action rat model sci base result von frey test ast treatment signific allevi sci induc neuropath pain compar control group p express analysi western blot show reduc express level cox tnf il il follow ast treatment p activ antioxid enzym evalu use elisa therefor elisa experi show signific reduct level oxid stress sci rat follow ast treatment p furthermor histopatholog evalu reveal myelin white matter motor neuron number signific preserv treatment ast p conclus studi show ast could improv sci anti inflammatori antioxid effect lead decreas tissu damag mechan pain sci | D000975;D013119 | T044;T121;T123;T039;T037 |
34,688,831 | neuroprotect anti neuropath action puls magnet field low frequenc rat chronic peripher neuropath pain manag chronic peripher neuropath pain condit convent treatment still limit present studi aim determin anti neuropath action puls magnet field pmf treatment therapeut effect daili pmf treatment week investig examin pain behavior hyperalgesia allodynia electrophysiolog paramet amplitud compound action potenti cap sciatic nerv conduct veloc sncv histopatholog chang rat chronic constrict injuri cci peripher central pro inflammatori cytokin tnf il il chemokin ccl cxcl angiogen factor vegf bfgf sciatic nerv spinal cord tissu also measur determin possibl molecular action mechan pmf treatment hyperalgesia allodynia observ first week last week cci pmf treatment caus time depend anti hyperalges anti allodyn effect pmf treatment allevi histopatholog consequ cci sciatic nerv signific improv amplitud cap sncv pmf treatment inhibit pro inflammatori molecul promot anti inflammatori cytokin neural tissu pmf treatment also suppress vegf level enhanc bfgf level neural tissu result present studi suggest daili pmf treatment may neuroprotect anti neuropath pain action rat cci induc neuropathi due modul effect neuro inflammatori neuro angiogen mediat central peripher neural tissu | D060526;D009437;D018696 | T047;T121;T184;T169;T070 |
34,688,830 | young older adult exhibit expans cdra ccr cd follicular helper cell respons tetanus vaccin subset cd cell known follicular helper tfh provid co stimul signal requir establish long term humor immun recent studi shown reduc frequenc function popul older adult comparison young adult respons vaccin evalu whether memori generat circul tfh ctfh cell contribut phenomenon memori subpopul ctfh activ degre evalu ex vivo vitro respons model antigen tetanus toxoid tt first dose tetanus vaccin report lower frequenc ctfh vaccin older adult compar young adult moreov wherea ctfh older adult prefer expand effector memori phenotyp young adult experienc tempor increas ccr cdra ctfh cell also display higher level cd cdl cxcr bcl upon antigen encount phenotyp confirm use automat algorithm conclus result suggest age relat loss heterogen expans differenti memori cell within ctfh compart could affect respons older individu vaccin make phenotyp characterist featur immunosenesc | D000367;D000084522;D013745 | T116;T121;T079;T025;T129 |
34,688,829 | withdraw temporari mechan circulatori support patient capac littl known real time decis make process patient capac choos withdraw temporari mechan circulatori support mcs | D015199;D011788 | T061;T078 |
34,688,828 | microrna b amelior hepat inflamm via suppress stat alcohol associ liver diseas alcohol associ liver diseas ald induc chronic excess alcohol consumpt result clinic manifest steatosi inflamm cirrhosi microrna b mir b main express hepat nonparenchym cell express level vari differ diseas studi aim determin role mir b mous model alcohol associ liver diseas wild type wt mir b knockout mir b mice fed lieber decar liquid diet contain alcohol day follow gavag singl dose ethanol gkg bodi weight histolog immunoblot biochem analys conduct comparison mir b express decreas liver chronic plus bing ethanol fed mice analysi reveal alcohol exposur exacerb hepat injuri signific increas serum alanin aminotransferas alt aspart aminotransferas ast level decreas surviv rate mir b mice result luciferas assay indic mir b negat regul signal transduc activ transcript stat deplet mir b led increas stat notic inflamm liver wherea overexpress mir b downregul stat proinflammatori cytokin express primari mous periton macrophag taken togeth result demonstr novel associ mir b ald mir b play hepatoprotect role alcohol induc inflamm liver injuri target stat | D008108;D035683 | T047;T114;T123 |
34,688,827 | exposur acut stress affect retriev group relat bias healthi men individu tendenc show enhanc vigil group member stress regul hypervigil toward threaten stimuli shown promot reinstat group relat bias previous studi conduct women current studi examin exposur acut stress affect retriev group relat extinct bias male particip result show men exert specif group relat bias begin extinct train index higher skin conduct respons scrs toward group face stress led return extinguish group bias specif stress group show higher scrs toward group face retriev compar control group bias index negat relat post stress cardiovascular recoveri result indic import interact stress intergroup bias fear condit along potenti modul sex | D003214;D005108 | T041 |
34,688,826 | chang brain activ relat episod memori retriev adult singl domain amnest mild cognit impair present fmri studi aim character perform brain activ chang relat episod memori retriev adult singl domain amci sdamci relat cognit unimpair adult particip perform oldnew recognit memori task word bold signal acquir sdamci group show lower hit correct recognit old word lower abil discrimin old new word higher error longer reaction time hit group also display brain hypoactiv left precuneus left midcingul cortex success recognit old word chang brain activ suggest presenc neural dysregul brain region involv success episod memori retriev moreov hypoactiv brain area discrimin group moder sensit specif valu suggest might constitut potenti neurocognit biomark sdamci | D060825;D061212 | T048;T041 |
34,688,823 | molecular mechan thermodynam studi rosuvastatin interact human serum albumin use surfac plasmon reson method combin multi spectroscop molecular model approach rosuvastatin ros anti cholesterol drug belong statin drug multi spectroscop approach combin molecular model techniqu use assess ros associ human serum albumin hsa besid hsa immobil surfac plasmon reson spr chip use obtain kinet paramet ka kd k fluoresc quench titrat reveal ros interact hsa via dynam exotherm enthalpi driven mechan hydrogen bond van der waal interact preval bond forc contribut ros hsa complex format ros bind hsa alter hsa conform spr result indic ros hsa strong interact possess equilibrium constant k k competit analysi site marker show ros higher tendenc bind warfarin bind site site iia may explain warfarin higher anticoagul effect ros user fret analysi indic non radiat energi transfer occur ros hsa accord molecular dock studi ros prefer bind site ib iia ros hsa complex stabil due hydrogen bond interact presenc hydrogen bond donor acceptor well aromat ros moieti facilit interact | D000075462;D020349 | T116;T121;T063 |
34,688,820 | interact genet polymorph fto mcr mthfr gene adher mediterranean diet relat obes investig potenti interact genet background adher mediterranean diet macronutri intak physic activ regard obes sampl healthi adult | D038441 | T061 |
34,688,819 | genom wide identif nitrat transport nrt gene famili function analysi menrt cassava manihot esculenta crantz nitrat transport nrt protein play import role nitrat uptak util plant nrt famili identifi function character mani plant howev systemat identif nrt famili member report cassava manihot esculenta crantz studi six menrt gene identifi cassava genom name menrt accord chromosom locat phylogenet tree show nrt protein divid four main subgroup support gene structur conserv motif six menrt gene random distribut chromosom lg lg lg lg two tandem duplic gene menrtmenrt pair segment duplic gene menrtmenrt detect subsequ express profil menrt gene eight differ tissu respons nitrat defici treatment analyz result show menrt gene differenti express pattern menrt gene induc nitrat defici menrt highest express level treatment arabidopi transform menrt gene show higher fresh weight wild type plant respons n starvat suggest menrt play import role adapt low nitrogen taken togeth result provid refer analys molecular function menrt gene famili also candid gene develop nitrogen effici crop | D018506;D010802 | T062;T045;T078 |
34,688,818 | associ genet variant oxid stress relat gene osteoporot bone fractur hortega follow studi wide accept etiopathogenesi hypothesi origin osteoporosi complic consequ bone age environment factor togeth genet predisposit evid suggest oxid stress crucial bone patholog associ age aim studi determin whether genet variant oxid stress relat gene modifi risk osteoporot fractur analys patient control hortega sampl year follow studi genotyp allel distribut snps gene involv oxid stress result show carrier variant allel snp rs within txnrd princip genet risk factor associ osteoporot fractur variant allel rs mpr rs txnrd rs gpx rs txn rs gpx polymorph import genet risk factor fractur studi provid inform genet factor associ oxid stress involv risk osteoporot fractur reinforc hypothesi genet factor crucial etiopathogenesi osteoporosi complic | D020641 | T086 |
34,688,815 | explor weight scheme base allel frequenc annot weight burden associ analysi complex phenotyp weight burden analysi incorpor variant differ frequenc annot combin test associ gene phenotyp howev systemat explor weight scheme provid maximum power detect associ assess differ weight scheme use number gene exom wide evid associ common phenotyp obtain exom sequenc uk biobank particip find mark differ optim weight scheme gene respect allel frequenc annot impli one size fit scheme general optim seem help weight rare variant high common one give loss function variant higher weight protein alter variant assign higher weight protein alter variant predict sever effect howev data current avail seem possibl make specif recommend research conduct use uk biobank resourc | D005787;D008957 | T081;T170;T078 |
34,688,813 | cypa cypa cypa genet polymorph recipi rather donor influenc tacrolimus concentr earli stage liver transplant purpos studi investig effect cypa cypa cypa genet polymorph liver transplant recipi donor tacrolimus concentr earli stage liver transplant | D016031 | T061 |
34,688,811 | cb receptor antagonist revert effect cannabidiol cue stress induc reinstat cocain seek behaviour mice pharmacolog treatment yet approv patient cocain use disord cannabidiol constitu c sativa plant shown promis result rodent model drug addict howev specif effect mechan action cannabidiol rodent oper model extinct base abstin drug seek relaps remain unclear cannabidiol mgkg ip inject extinct train male cd mice previous train self administ cocain mgkginfus evalu reinstat cocain seek induc cue stress stimuli footshock found cannabidiol mgkg modul extinct learn cannabidiol mgkg treatment increas level cb receptor protein found prelimb orbitofront region prefront cortex ventral striatum effect parallel reduct striatal fosb accumul increment glur ampa receptor subunit furthermor cue induc reinstat cocain seek attenu cannabidiol unexpect cannabidiol mgkg facilit stress induc restor cocain seek behaviour ascertain particip cb receptor behaviour chang administ cb antagonist mgkg reinstat session attenu cue induc reinstat facilit stress induc reestablish abolish cannabidiol mgkg treat mice result reveal seri complex cb relat chang induc cannabidiol vari impact reinstat cocain seek behaviour could limit therapeut applic | D003463;D058999 | T033;T078 |
34,688,810 | aberr larg scale brain modul deficit non deficit schizophrenia schizophrenia heterogen psychiatr diseas deficit schizophrenia ds clinic subgroup primari endur negat symptom although previous neuroimag studi identifi function connectom alter schizophrenia modular organ ds nondeficit schizophrenia nds remain poor understood therefor studi aim investig modular level alter ds patient compar nds healthi control hc group | D063132;D000082702;D012559 | T091;T017;T029;T048 |
34,688,809 | radiotherapi treatment optic nerv sheath meningioma systemat review meta analysi manag optic nerv sheath meningioma onsm suffer signific shift due new radiat techniqu howev conclus inform approach present better result literatur meta analysi aim evalu outcom differ radiotherapi rt modal manag onsm | D008577;D008579;D019574 | T191 |
34,688,808 | deep learn model automat contour cardiovascular substructur radiotherapi plan ct imag dosimetr valid reader studi base clinic accept test larg radiotherapi rt plan imag dataset consist contour cardiovascular structur essenti robust cardiac radiotox research thorac cancer studi aim develop valid high accur automat contour model heart cardiac chamber great vessel rt plan comput tomographi ct imag use dose volum paramet estim | D002289;D000077321;D008175 | T191;T066 |
34,688,807 | proton reirradi recurr new primari breast cancer set prior breast irradi late local recurr second primari breast cancer increas common proton beam therapi pbt reirradi rert may allow safer deliveri second definit radiotherapi rt cours analyz outcom patient recurr new primari breast cancer underw rert | D001943;D061766;D000069475 | T191;T061 |
34,688,806 | microrna b p target purinerg px receptor regul central poststrok pain rat central poststrok pain cpsp neuropath pain syndrom usual occur cerebrovascular accid current pathogenesi cpsp fulli understood purinerg px receptor pxr implic neuropath pain includ cpsp herein demonstr level microrna b p mir b p target pxr transcript signific downregul ventral posterolater nucleus thalamus vpl cerebrospin fluid csf plasma cpsp rat express level mir b p negat correl sever allodynia genet knockdown pxr vpl protect cpsp rat allodynia similar genet overexpress mir b p vpl revers allodynia establish cpsp rat via downregul pxr express treatment use gabapentin cpsp rat signific restor decreas mir b p express vpl csf plasma block allodynia cpsp rat administr mir b p inhibitor vpl abolish antiallodyn activ gabapentin mechan associ pxr express involv endogen opioid system human patient cpsp show decreas plasma level mir b p compar control particip logist regress analysi patient cohort show determin plasma level mir b p may use cpsp diagnosi treatment | D035683;D009437 | T047;T114;T184;T123 |
34,688,803 | induct apoptosi eleutherin bulbosa mill urb bulb extract optimis extract condit human retinoblastoma cancer cell weri rb bulb eleutherin bulbosa mill urb indigen medicin plant tradit use among dayak peopl manag diabet breast cancer hypertens stroke fertil problem women bulb report potent cytotox potenti limit under mechan | D008517 | T061 |
34,688,802 | hura crepitan stem bark extract potenti remedi sub acut liver damag hura crepitan common use treat liver diseas nigeria ghana previous studi support ethnomedicin use protect liver present studi aim assess effect h crepitan stem bark subacut carbon tetrachlorid ccl induc liver damag rat | D008517 | T061 |
34,688,797 | pseudevernia furfuracea inhibit migrat invas colorect carcinoma cell line pseudevernia furfuracea l zopf common lichen speci tradit use worldwid treat various medic condit among intestin issu cancer studi focus main cytotox potenti lichen whilst antimigratori antiinvas properti often disregard migrat invas cancer cell pivot process cancer metastasi wherein cancer cell abl migrat individu form coher mass one success strategi anticanc treatment target wnt catenin signal pathway aberr activ colorect carcinoma well lower level migratoryinvas marker | D008011 | T002 |
34,688,796 | effect air purifi intens care unit intervent studi effect design oper intens care unit icu ventil system import prevent hospit acquir infect air purifi may contribut | D061808;D003428 | T047;T073 |
34,688,795 | establish prognost model ten transcript factor gastric cancer transcript factor tfs play import role tumor integr analyz gpl platform gastric cancer gc microarray identifi independ prognost tfs construct gc prognost model use gse verif set kaplan meier curv show signatur distinguish surviv rate gc patient p auc valu respect compar clinicopatholog characterist signatur independ prognost factor p nomogram establish base model five year calibr curv verifi predict nomogram almost consist actual surviv rate c index indic moder prognost abil analysi target gene tfs show close relat progress gc extern databas rt pcr show rna protein express tfs consist analysi | D013274 | T191 |
34,688,794 | scope review decad outcom nonsurg root canal treatment nonsurg retreat apexif studi part process general result despit initi standard report varianc studi design outcom assess tool use persist literatur review scope exist literatur endodont outcom studi futur develop core outcom set | D056624;D003786 | T030;T061 |
34,688,793 | scope review decad outcom nonsurg root canal treatment nonsurg retreat apexif studi part outcom measur inconsist definit endodont outcom terminolog jeopard evalu propos intervent patient care qualiti scope review aim provid groundwork develop set basic outcom endodont | D056624;D011788 | T061;T078 |
34,688,792 | scope review four decad outcom nonsurg root canal treatment nonsurg retreat apexif studi part propos framework standard data collect report endodont outcom studi despit initi standard improv report rapid grow endodont outcom research studi issu relat miss ambigu inform still great concern articl propos framework standard data collect compil checklist report various studi design endodont outcom | D056624;D003786 | T030;T061 |
34,688,790 | blood deriv extracellular vesicl regen medicin therapeut regen promis nanos extracellular vesicl ev secret cell wide explor recent capac ev purifi blood elicit regen effect begun evalu blood might readili avail sourc ev avoid need extens cell cultur specif issu complic use biofluid area assess evid blood contain regen materi progress made toward deliv blood deriv ev regen therapeut difficulti relat complex blood promis hydrogel base deliveri ev | D000067128;D044968 | T091;T026 |
34,688,789 | shape gut microbiota bioactiv phytochem emerg approach prevent treatment human diseas human digest tract cottag trillion live microorgan regul health ill healthi gut microbiota gm necessari prevent microbi growth bodi growth obes cancer diabet enhanc immun equilibrium gm composit presenceabs critic speci enabl specif respons essenti host better health condit research evid reveal dietari plant bioactiv phytochem bps play extens critic role shape gm get benefici health effect bps also known improv gastrointestin health reduc risk sever diseas modul gm mediat cellular molecular process regular intak bps rich veget fruit herbal prepar promot probiot bacteria includ bifidobacteria lactobacillus speci inhibit unwant gut resid develop escherichia coli salmonella typhimurium etc upon consumpt bps contact gm get transform absorb gastrointestin tract biotransform bps gm link enhanc bioactivitytox diminish bps compar parent phytochem therefor current review focus role bps shape gm prevent treatment human diseas | D003920;D000069196;D009369;D009765 | T191;T007;T047;T001 |
34,688,788 | character thermophil facult anaerob bacterium paenibacillus sp strain da c exhibit xylan degrad anaerob condit screen identif studi function properti cellulolyt xylanolyt bacteria crucial construct applic bioprocess thermophil facult anaerob xylanolyt bacteri strain da c jcmdsm exhibit effici xylan degrad newli isol compost strain da c complet degrad beechwood xylan within day anaerob condit rrna gene sequenc homolog phylogenet tree analysi strain da c close relat paenibacillus cisolokensi xylanibacillus composti howev averag nucleotid ident digit dna dna hybrid valu base genom inform carbon sourc util properti indic strain da c belong paenibacillus rather xylanibacillus gene number xylanas endoglucanas strain da c x composti differ howev strain da c higher abund l arabinofuranosidas xylosidas glucosidas x composti strain da c show decreas xylan corn hull degrad abil growth xylan medium aerob condit quantit pcr show high express xylan cellulos degrad gene anaerob condit gene repress aerob condit indic strain da c control polysaccharid degrad depend aerat condit strain da c new speci paenibacillus uniqu polysaccharid degrad system | D056507;D014990 | T007;T109 |
34,688,787 | valoris wast cook oil use mix cultur short medium chain length polyhydroxyalkano effect concentr temperatur ammonium product polyhydroxyalkano phas wast cook oil wco mix cultur investig present studi increas wco concentr temperatur ammonium avail pha product done two step first step mix cultur enrich pha accumul bacteria activ sludg sequenc batch reactor oper feast famin mode second step pha accumul enrich mix cultur assess batch reactor enrich step two substrat wco nonano acid use enrich pha accumul step wco use possibl enrich mix cultur pha accumul bacteria use wco substrat due develop filament bacteria caus foam format bulk reactor howev result show mix cultur continu fed nonano acid enrich pha accumul bacteria enrich cultur accumul scl mcl pha use wco substrat maximum pha accumul capac mix cultur wco cdw increas temperatur wco concentr gl increas pha accumul capac mix cultur ratio scl pha mcl pha presenc ammonium increas pha accumul cdw compar complet absenc ammonium cdw thermal character pha exhibit advantag properti scl mcl pha ie higher melt temperatur similar scl pha lower degre crystallin similar mcl pha first studi report potenti open mix cultur produc scl mcl pha wco thus contribut understand sustain polym product | D064751;D054813 | T104;T197;T109 |
34,688,785 | apoptosi versus surviv african hors sick virus serotyp infect hors peripher blood mononuclear cell expand previous work studi use transcriptom analysi rna sequenc investig various factor contribut either induc apoptosi result cell death promot surviv african hors sick virus serotyp ahsv infect hors peripher blood mononuclear cell pbmc h apoptosi host defens mechan prevent virus replic accumul spread progeni virus ahsv infect pbmc kill via intrins perforingranzym pathway apoptosi attenu ahsv attahsv vivo primari secondari immun respons train innat immun play import role circumv viral interfer result elimin ahsv infect pbmc intrins extrins pathway apoptosi virul ahsv virahsv vitro secondari immun respons oxid stress conjunct ire pro apoptot signal play major role induct intrins pathway apoptosi cytotox lymphocyt induc perforingranzym extrins pathway apoptosi contrast ahsv infect pbmc surviv virahsv vitro primari immun respons allow unrestrain viral replic virahsv interfer innat immun respons result impair nk cell respons delay immun respons togeth antioxid defens system promot ahsv infect pbmc surviv | D000355;D000356 | T047;T005 |
34,688,784 | character genom analysi novel vibrio parahaemolyticus phage vbvppde novel phage vbvppde infect vibrio parahaemolyticus isol sewer huangsha aquat market guangzhou transmiss electron microscopi indic de icosahedr head nm diamet short non contractil tail nm genom de doubl strand linear dna length bp gc content total putat open read frame orf predict could divid six modul dna metabol lysi packag structur addit function hypothet protein taxonom analysi reveal phage belong genus maculvirus autographivirina subfamili podovirida famili de short latent period min burst size pfucel optimum temperatur ph rang c c respect complet inactiv min ultraviolet irradi transfer rna trna virul associ antibiot resist gene identifi bacteri challeng test reveal de certain inhibitori effect v parahaemolyticus within h character genom analysi vitro antibacteri assay de enhanc understand phage biolog divers | D001435;D017902;D014736 | T007;T005 |
34,688,783 | character small interf rnas deriv pepper mild mottl virus infect pepper plant high throughput sequenc pepper mild mottl virus pmmov infect pepper plant induc sever yield loss china howev molecular interact pmmov pepper plant larg unknown rna silenc eukaryot conserv mechan virus mediat virus deriv small interf rnas vsirna plant studi profil vsirna pmmov infect pepper plant obtain high throughput sequenc result show vsirna predomin nucleotid nts length u bias termin singl nucleotid resolut map reveal vsirna heterogen distribut throughout pmmov genom rnas hotspot sens antisens strand main locat rdrp cp code region host transcript target vsirna predict main involv physiolog pathway relat stress respons cell regul metabol process addit pmmov infect induc signific regul caagoab cadcl cardr gene transcript pepper plant import compon involv antivir rna silenc pathway taken togeth result suggest possibl role vsirna pmmov pepper interact | D010935;D012367 | T047;T114 |
34,688,782 | new tetra segment splipalmivirus divid rdrp domain cryphonectria natercia fungus found chestnut cork oak tree europ posit sens singl strand ss rna virus divid rna depend rna polymeras rdrp domain report divers filament ascomycet sinc virus term splipalmivirus polynarnavirus character larg sequenc level ill defin biolog cryphonectria natercia one virus report ascomycet fungus potenti plant pathogen chestnut oak tree molecular character multipl virus singl portugues isol c c natercia take metatranscriptom convent doubl strand rna approach among novel splipalmivirus cryphonectria natercia splipalmivirus cnspv novel fusagravirus cryphonectria natercia fusagravirus cnfgv studi focus former virus cnspv tetra segment ssrna genom rna rna observ splipalmivirus report rdrp domain separ encod rna motif f b rna motif c hypothet protein encod proxim open read frame rna show similar counterpart conserv splipalmivirus rna encod protein rna encod protein show similar known protein blastp search tetra segment natur confirm conserv termin sequenc four cnspv segment rna rna coexist singl conidi isol test experiment introduct cnspv along cnfgv virus free strain c c natercia veget incompat c result phenotyp alter suggest asymptomat infect protoplast fusion assay indic consider narrow host rang cnspv restrict speci c natercia c carpinicola studi contribut better understand molecular biolog properti uniqu group virus | D001203;D029963;D012328;D014780 | T004;T002;T005 |
34,688,781 | quantif intrahepat cccdna hbv associ hepatocellular carcinoma improv ddpcr method quantif intrahepat coval close circular dna cccdna import assess effici anti hbv therapi exonucleas treatment essenti real time quantit pcr qpcr droplet digit pcr ddpcr measur improv specif cccdna quantif research compar limit detect lod qpcr ddpcr evalu digest effici three exonucleas treatment psad exonucleas iii exonucleas measur cccdna cell clinic sampl ddpcr demonstr lod ddcpr copiesreact much lower qpcr copiesreact indic ddpcr sensit qpcr meanwhil compar psad exo iii ung exonucleas treatment combin ddpcr effect detect intrahepat cccdna clinic sampl final median intrahepat cccdna copi cell pair hcc sampl determin improv ddpcr method therefor develop optim ddpcr method use absolut quantif low level intrahepat cccdna precis | D006528;D008113 | T191 |
34,688,780 | leadership divers scienc women editor dental journal underrepres compar women editor medic journal increas number women enter dentistri medicin anticip global leadership posit repres demograph studi proport women editor promin medic dental journal compar | D007857;D010506 | T170;T073;T054;T078 |
34,688,779 | web base intervent improv evid practic gap minim intervent dentistri find dental practic base research network determin whether evid practic gap epg minim intervent dentistri mid improv tailor web base intervent specif clinic situat might imped implement mid | D000079382;D000071836 | T058;T033 |
34,688,778 | effect implant locat oper accuraci implant scan use combin heal abut scan bodi system investig effect implant locat oper accuraci implant scan conduct combin heal abut scan bodi cha sb system | D015921;D003761 | T074;T061 |
34,688,777 | glucocorticoid inhibit human hematopoiet stem cell differenti toward common ilc precursor innat lymphoid cell ilc compris cytotox natur killer nk cell helper ilc hilc human hilc develop less character compar nk cell although ilc development relat report immunosuppress drug glucocorticoid gcs regul ilc function whether control ilc differenti hematopoiet stem cell hscs unknown | D005938;D007113 | T032;T039;T109;T125 |
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