PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,688,776 | inborn error immun recent progress recent advanc field inborn error immun iei wide scope includ progress mechan diseas diagnosi manag new gene defect affect immun respons continu report mani year note present iei might includ recurr infect case current diagnost method identifi molecular caus patient sever combin immunodefici progress immunopathogenesi explain mechan lead symptom autosom recess hyper ige syndrom emphasi research primari antibodi defici benefit antibiot prophylaxi reduc frequenc infect demonstr patient regimen rituximab azathioprin mycophenol proven effect chronic granulocyt interstiti pneumonia efficaci advers event hematopoiet stem cell transplant differ iei condit report well differ strategi improv outcom support use immunodefici immunodysregulatori syndrom recent pandem coronavirus diseas affect patient iei particular defici interferon mediat activ immun respons initi data suggest coronavirus diseas vaccin might elicit anti coronavirus diseas neutral antibodi respons patient iei condit | D000086382;D030342;D007153;D000081207 | T047;T067 |
34,688,774 | climat chang global issu allergi immunolog steadi increas global temperatur result combust fossil fuel accumul greenhous gase ghgs continu destabil ecosystem worldwid although annual emiss must halv reach net zero limit catastroph impact associ warm planet world effort curb ghg emiss fall short commit made pari agreement effect juli recent declar hottest month ever record year ramif chang global temperatur complex promot outdoor air pollut pollen exposur extrem weather event besid worsen respiratori health air pollut promot atopi suscept infect effect ghgs pollen affect frequenc sever asthma allerg rhiniti chang temperatur air pollut extrem weather event exert advers multisystem health effect disproport affect disadvantag vulner popul review articl updat allergist immunologist health impact climat chang alreadi evid daili practic also call action advocaci includ integr climat chang relat mitig educ adapt measur protect patient avert injuri planet | D000486 | T091 |
34,688,773 | postop pain relief follow lumbar erector spina plane block patient undergo percutan nephrolithotomi random control trial test whether lumbar erector spina plane block espb provid superior analgesia compar placebo patient undergo percutan nephrolithotomi pcnl use reduct postop opioid consumpt delay rescu analgesia demand reduct pain score outcom measur | D000074642;D009407 | T061 |
34,688,772 | nccn risk reclassif black men low intermedi risk prostat cancer genom test assess util genom test risk stratifi black patient low intermedi risk prostat cancer | D011471 | T191 |
34,688,770 | scope review econom burden non cancer genitourinari condit provid scope review econom burden non cancer genitourinari condit ncguc | D056887;D001750;D053201;D014549 | T048;T047;T046;T020 |
34,688,769 | thalamocort dysconnect lifelong prematur ejacul function mri studi detect seed base function connect fc various cortic sub region thalamus lifelong prematur ejacul lpe patient explor whether specif thalamocort network signific alter pe patient compar healthi control hcs method fifti non medic lpe patient age match hcs underw rest state function mri fc adopt identifi specif thalamocort connect thalamus cortic region interest ie motor cortexsupplementari motor prefront cortex tempor lobe posterior pariet cortex somatosensori cortex occipit lobe lpe patient regress analysi subsequ conduct assess relationship thalamocort connect prematur ejacul diagnost tool pedt score intravagin ejaculatori latenc time ielt | D002540;D009415;D061686;D013788 | T048;T023;T029 |
34,688,768 | foliar carbon dot amend modul carbohydr metabol rhizospher properti drought toler maiz seedl improv maiz drought toler great import scale product due food secur popul growth carbon dot cds synthes hydrotherm method citric acid ethylenediamin carbon sourc cds ml mgl spray th day old maiz zea may l drought stress soil moistur seven consecut day spray ultra pure water control physiolog paramet rhizospher properti maiz drought evalu foliar spray cds mgl could increas root exud eg succin acid fold pyruv acid fold betain fold modifi microbi communiti particular relat abund pseudomona sphingomona nitrospira conocyb signific increas respect alter microbi abund could improv soil avail nitrogen phosphorus respect increas plant water uptak chang exud synthesi microbi abund could driven signific increas net photosynthesi rate carbohydr content shoot root respect upon foliar applic cds meanwhil fresh weight shoot root increas dri weight shoot root increas respect result demonstr foliar applic cds could improv rhizospher environ enhanc maiz drought toler even growth therefor foliar applic cds would promis strategi sustain nano agricultur respons drought stress | D055864;D003313 | T070;T002;T168 |
34,688,767 | predict bioaccess lead urban suburban soil vis nir diffus reflect spectroscopi success use visibl near infrar vis nir reflect spectroscopi analysi requir select optim procedur data acquisit accur model approach studi vis nir nm wavelength appli detect differ form lead pb spectral activ soil constitu combin princip compon regress pcr partial least squar regress plsr vis nir model calibr three cloud differ soil spectral properti divid linear discrimin analysi lda categori pb contamin risk low health ecolog rang mg kg farm soil use calibr n pollut garden soil n new york citi use valid total bioaccess pb concentr examin plsr model compar support vector machin svm regress boost regress tree brt model perform model predict qualit evalu root mean squar error rmse residu predict deviat rpd coeffici determin r total pb best predict model obtain brt r rmse mg kg follow svm valid r rmse mg kg last plsr valid r rmse mg kg plsr techniqu accur calibr model bioaccess pb r valu rmse mg kg regress analysi indic bioaccess pb strong influenc organ content lesser extent fe concentr although plsr obtain lower accuraci model select mani characterist band thus provid accur approach pb pollut monitor | D007854;D012987 | T167;T131;T196 |
34,688,766 | compar effect alga macrophyt residu degrad biolog nitrogen fixat freshwat lake sediment degrad miner organ residu import factor drive biochem process lake ecosystem howev effect organ matter degrad biolog nitrogen fixat bnf freshwat lake sediment remain poor understood studi investig respons sediment nitrogen fixat degrad alga macrophyt residu continu flow mesocosm combin nifh sequenc analysi isotop trace result suggest activ nitrogen fixat sediment occur first two week rapid degrad organ residu degrad alga macrophyt residu quick increas nifh abund nitrogenas activ na sediment howev maximum na trigger alga degrad ng g day six time higher induc degrad macrophyt residu signific differ na sediment degrad potamogeton phragmit redund analysi rda show variat diazotroph communiti sediment signific p correl concentr nh over water fe ii content eh sediment overal bnf sediment quick respond degrad organ residu degrad alga stronger promot effect nitrogen fixat sediment macrophyt residu | D060106;D009586 | T040;T070;T083 |
34,688,765 | factor control spatial variabl soil aggreg associ organ carbon across semi humid watersh soil aggreg sa play crucial role soil organ carbon soc sequestr differ sa fraction contribut differ sequestr soc howev studi examin factor control sa fraction associ soc content across watersh soil sampl collect cm surfac layer cm subsurfac layer site across semi humid watersh km loess plateau china sampl separ macroaggreg microaggreg mi silt clay fraction sc wet siev soc content fraction determin object investig spatial variabl sa fraction associ soc content well main control across entir watersh explor linkag soil aggreg soc sequestr bulk aggreg soc content sa fraction show moder variabl coeffici variat geostatist analysi indic spatial pattern sa fraction soc content vari aggreg size combin spearman correl analysi structur equat model found soil textur import control spatial variabl sa fraction associ soc content veget dynam manag practic associ land use also import control mi associ soc content especi surfac layer howev sc associ soc content sensit eco hydrolog process relat topographi among land use grassland greatest soc sequestr potenti fine root herb wrap mi increas soc content within primari mechan respons soc sequestr grassland result indic use veget fine root system restor good strategi increas soc sequestr region | D002244;D012987 | T167;T121;T196 |
34,688,764 | microplast pelag dolphinfish coryphaena hippurus eastern pacif ocean implic fish health microplast pollut fish grow concern worldwid due implic human health microplast contamin impact investig wild caught commerci import dolphinfish coryphaena hippurus l eastern pacif ocean water suspect particl extract gill esophagus stomach intestin tract muscl c hippurus identifi microplast microscop inspect micro raman spectroscop analysi microplast particl extract gill esophagus stomach intestin tract muscl respect overal microplast detect fish piec per individu averag preval high incid occurr microplast c hippurus suggest pelag speci high risk exposur microplast pollut chemic composit microplast made polyest pes polyethylen terephthal pet polypropylen pp polystyren ps polyethylen polypropylen copolym pe pp polyethylen pe microplast fish mm mm respect microplast mm mm rough share equal remain molecular dock result impli interact four domin microplast polym pes pet pp ps cytochrom p would lead impair reproduct function c hippurus find provid insight harm microplast exposur along quantit inform occurr abund distribut microplast fish tissu ultim improv understand bioavail hazard microplast organ beyond human via food chain transfer | D000080545;D014874 | T131;T122 |
34,688,763 | heavi metal transport function mechan regul applic phytoremedi heavi metal pollut soil global problem serious impact human health ecolog secur phytoextract phytoremedi plant uptak transport heavi metal hms tissu aerial part environment friend method reduc total amount hms soil wide applic prospect howev molecular mechan phytoextract still investig uptak transloc retent hms plant main mediat varieti transport protein better understand accumul strategi hms via transport plant prerequisit improv phytoextract review biochem structur function hm transport famili plant systemat summar emphasi role phytoremedi accumul mechan regulatori pathway relat hormon regul reactiv oxygen speci ros hms concern transport describ detail scientif effort practic phytoremedi carri recent year suggest creation hyperaccumul transgen gene edit techniqu target transport regul ultim power path phytoremedi hm contamin soil | D019216;D012989 | T131;T196 |
34,688,762 | crop pattern optim coordin economi environ consid hydrolog uncertainti rapid growth popul economi shortag mismatch land water resourc deepen need crop pattern optim context sustain develop agricultur crop pattern optim pursu econom benefit consequ environment effect also deserv equal attent meanwhil climat chang increas complex balanc conflict econom environment system crop pattern optim therefor paper build multi object program model econom environment synergist optim crop pattern climat chang eeso cp cc model goal econom benefit increment environment pollut emiss reduct eeso cp cc model coupl non point sourc pollut input output model one dimension water qualiti model econom benefit function integr framework fuzzi method use solv optim model stochast uncertainti water suppli climat chang quantifi integr bayesian approach interv linear regress model appli jinxi irrig district jxid heilongjiang provinc northeast china result show adjust acreag rice corn soybean harmoni degre economi societi environ system increas compar current situat indic model tend achiev best possibl econom benefit ensur environment effect compar actual crop pattern pollut emiss reduc corn soybean respect howev led decreas econom benefit exchang show trade environment pollut reduct econom benefit improv output coeffici nitrogen phosphorus pollut optim optim output reduc compar standard crop pattern water resourc alloc vari differ climat chang condit howev amplitud variat modest indic model cope well chang environ develop model help achiev synergist develop econom benefit environment effect thus promot sustain develop irrig area improv cope capac agricultur water land climat chang crop pattern optim plan | D000383;D062070 | T090 |
34,688,761 | pangenom function investig dormanc biodegrad featur organ pollut degrad bacterium rhodococcus biphenylivoran tg environment bacteria contain wealth untap potenti form biodegrad gene leverag potenti often confound lack understand fundament surviv strategi like dormanc environment stress investig bacteri dormanc degrad relationship enabl improv bioremedi coupl genom function assess provid context key attribut organ pollut degrad strain rhodococcus biphenylivoran tg whole genom sequenc pangenom analysi function character perform elucid import gene gene product includ antimicrobi resist dormanc degrad rhodococcus genus strong potenti degrad dormanc demonstr use r biphenylivoran tg model identifi four resuscit promot factor rpf encod gene tg involv dormanc resuscit demonstr r biphenylivoran tg grow fourteen typic organ pollut exhibit robust abil degrad biphenyl sever congen polychlorin biphenyl induc tg dormant state demonstr pronounc differ morpholog activ togeth result expand understand genus rhodococcus relationship dormanc biodegrad presenc environment stressor | D004785;D011078;D012240 | T131;T007;T109 |
34,688,760 | impact river dam phosphorus migrat case pubugou reservoir dadu river china reservoir agricultur catchment retain larg proport inflow phosphorus p howev effect reservoir p cycl relat biogeochem process remain unclear therefor studi investig degre typic river transit reservoir southwest china retain inflow particul phosphorus pp dissolv total phosphorus dtp various form p sediment differ water season normal water season nws low water season lws high water season hws proport inflow pp dtp retain respect result could attribut absorpt dtp larg load intercept sediment dam intercept pp rank water season term proport load inflow tp retain lws p yr nws p yr hws p yr might due high p concentr mg l long hydraul retent time hrt lws long term high rate retent bioavail phosphorus bap sediment result could attribut combin effect fine sediment particl organ matter om addit hrt r p affect retent p signific p concentr r p dam intercept lws result high bap content mg kg sediment high p concentr mg l weak hydrodynam hrt over water therefor regulatori measur urgent demand lws prevent reservoir algal bloom | D045483;D014874 | T070;T131 |
34,688,759 | inter storm variat microplast concentr polym type stormwat outfal bioretent basin microplast mp common report pollut freshwat marin soil environ studi date report mp concentr polym type observ stormwat particular catchment separ storm sewer object studi determin microplast concentr polym fingerprint inter storm variat mp two stormwat outfal bioretent basin composit stormwat sampl collect site across three rain event catchment urban suburban land use particl collect separ two size class treat wet peroxid oxid densiti separ nacl buoyant particl fragment film sphere collect analysi attenu total reflect fourier transform infrar spectroscopi atr ftir signific differ observ total polym concentr profil sampl site potenti due differ land use within catchment sampl size class highest mp concentr observ sampl bioretent basin compar stormwat outfal sampl indic potenti green infrastructur captur mp size rang studi weak signific negat correl observ cumul rainfal cm mp concentr correl observ anteced dri day mp concentr data repres conserv measur mp concentr given fiber particl gml target target particl analyz atr ftir overal result present provid insight load charact size morpholog polym type buoyant mp particl stormwat may use design mitig strategi | D000080545;D014874 | T131;T122 |
34,688,758 | effect agricultur landscap structur insecticid residu pollen divers life histori trait red mason bee osmia bicorni agricultur landscap chang substanti recent decad shift domin small field divers crop system toward larg scale monocultur l landscap heterogen disappear studi artifici nest red mason bee osmia bicorni place l landscap type perimet oilse rape field repres differ oilse rape coverag orc land cover local landscap structur around nest characteris within radius use orc landscap characterist reduc non metric multidimension scale nmds two axe nmds characteris dataset primarili accord land fragment main crop wherea nmds captur preval natur area landscap pollen divers insecticid risk level pollen provis collect bee analys depend landscap structur test thereaft effect pollen divers insecticid risk landscap structur life histori trait bee sensit topic appli dursban ec determin pollen taxa rich singl nest rang pesticid detect pollen concentr ngg desmedipham bicorni forag rang relat larg indic landscap structur within radius around nest import speci pollen divers studi area minor import bee perform orc landscap structur signific affect life histori trait bee contamin pollen insecticid affect bee decreas mass newli emerg adult sensit dursban ec relat environment variabl | D029688;D007306;D010573 | T131;T002;T168 |
34,688,757 | calcium hypochlorit pretreat improv thermophil digest wast activ sludg upflow anaerob sludg blanket reactor anaerob wast activ sludg digest wide appli reduc sludg volum generat bioenergi form methan howev anaerob digest perform often challeng poor hydrolysi biomass cellular structur present studi feasibl use calcium hypochlorit ca clo improv thermophil digest studi two thermophil upflow anaerob sludg bed uasb reactor one one without ca clo pretreat oper day low high organ load rate olr condit correspond hydraul retent time hrt day day respect reactor achiev satisfi perform studi period low olr condit ca clo pretreat signific improv total volatil solid vs remov effici methan yield n mlg vs howev signific improv observ high olr condit gs gfervidobacterium predomin bacteria thermophil uasb reactor fed ca clo pretreat methanosarcina domin archaea reactor treatment mechan applic potenti use ca clo enhanc digest discuss | D019149;D012722 | T069;T074 |
34,688,756 | stereoselect toxic mechan neonicotinoid dinotefuran honeybe new perspect spatial metabolom studi develop stereoisomer neonicotinoid pesticid lower toxic key prevent global popul declin honeybe wherea littl known situ metabol regul honeybe respons stereoisomer pesticid herein demonstr integr mass spectrometri imag msi untarget metabolom method disclos disturb metabol express level spatial differenti honeybe api cerana associ stereoisomer dinotefuran method afford metabol network map capabl regard wide rang metabolit involv multipl metabol pathway honeybe metabolom result indic metabol pathway honeybe signific affect dinotefuran r dinotefuran tricarboxyl acid tca cycl glyoxyl dicarboxyl metabol various amino acid metabol msi result demonstr cross regul spatial differenti crucial metabolit involv tca cycl purin glycolysi amino acid metabol within honeybe taken togeth integr msi metabolom result indic higher toxic dinotefuran aris metabol pathway disturb inhibitori role energi metabol result signific reduc degrad rate detoxif mechan view spatial metabolom find provid novel perspect develop applic pure chiral agrochem | D006146;D009574 | T109 |
34,688,755 | iron coat biochar allevi acid accumul improv methan product ammonium enrich condit high stress ammonia nitrogen swine manur anaerob digest smad negat impact methan yield effect iron coat biochar smad differ ammonium stress investig iron coat biochar prepar c bc fe larg specif surfac area cm g accept ammonium adsorpt capac mgg smad bc fe addit effect broke thermodynam barrier butyr acet acceler propion degrad act temporari electron acceptor promot direct interspeci electron transfer initi smad stage ammonium stress sharpli increas mgl mgl methanogenesi effici decreas biochem methan potenti decreas nmlg vs nmlg vs kinet analysi show predict valu smad may calcul accur use logist function modifi gompertz equat studi provid basic theoret data import kinet paramet intens product iron coat biochar larg scale applic smad | D064751 | T104;T197 |
34,688,754 | speciat metal indigen plant grow post mine area dihydroxynicotianamin identifi abund cu zn ligand hypericum laricifolium ag cu pb zn found princip metal contamin post mine area peru hualgayoc cajamarca studi metal distribut amongst root stem leav four indigen hypertoler plant speci arenaria digyna puya sp hypericum laricifolium nicotiana thyrsiflora indic signific transloc zn tf cu tf aerial plant organ substanti water extract fraction metal except digyna root stem studi metal speciat ultrahigh perform size exclus fast sec hydrophil ion interact hilic liquid chromatographi dual icp induct coupl plasma electrospray esi orbitrap ms detect reveal presenc nicotianamin deoxymugin acid copper zinc complex root stem leav n thyrsiflora puya sp nicotianamin alon digyna previous unreport compound dihydroxi nicotianamin identifi abund cu zn ligand h laricifolium presenc arsenobetain arsenosugar confirm esi ms ag pb hard transloc leav found high molecular speci one pb contain speci co elut fast sec icp ms rhamnogalacturonan ii pb complex common found wall plant | D020902;D019216;D012989 | T131;T002;T196 |
34,688,753 | glutamyl tail length cofactor f methanogen archaea methanosarcina thermophila methanoculleus thermophilus cofactor f synthes mani differ organ redox cofactor play crucial role redox reaction catabol biosynthet metabol pathway consist deazaflavin structur link via lactat oligoglutam chain vari length present studi methanogen archaea methanosarcina thermophila methanoculleus thermophilus cultiv differ carbon sourc coenzym f composit assay revers phase ion pair high perform liquid chromatographi fluorometr detect regard overal cofactor f product distribut f glutamyl tail length methanosarcina thermophila cultiv methanol acet mixtur acet methanol abund cofactor f f wherebi last digit refer number express glutamyl rest contrast oblig co reduc methanoculleus thermophilus abund cofactor f f methanosarcina thermophila relat proport express f tail length chang batch growth three carbon sourc time f f decreas f f increas relat proport comparison total f content contrast methanoculleus thermophilus relat abund differ f cofactor remain stabl also possibl differenti two methanogen archaea base glutamyl tail length cofactor f cofactor f concentr could assign methanosarcina thermophila four variant trend posit correl dna concentr total concentr cofactor could shown except variant methanosarcinathermophila acet sole carbon sourc could shown concentr mcra gene copi number total concentr cofactor | D019638 | T194 |
34,688,752 | air pollut high intens interv exercis implic anti inflammatori balanc metabolom cardiovascular respons high intens interv exercis hiie effect non pharmacolog tool improv physiolog respons relat health hiie perform urban center howev exercis expos traffic relat air pollut trap associ metabol anti inflammatori imbal cardiovascular diseas paradox combin potenti conflict health effect thus aim studi determin effect hiie perform trap exposur serum cytokin non target metabolom cardiovascular paramet fifteen particip perform hiie chamber capabl deliv filter air fa condit non filter air trap condit pollut site adjac exposur chamber non target blood serum metabolom blood serum cytokin blood pressur analys collect fa trap condit baselin min exercis h exercis trap increas il concentr time h exercis p chang anti inflammatori balanc il tnf ratio contrast fa led increas il il tnf ratio p time respect enrich analysi show incomplet fatti acid metabol trap condit p min exercis also overact keton bodi metabol p min h exercis trap exercis induc acut decreas systol blood pressur sbp observ min impair h exercis p find reveal trap potenti attenu health benefit often relat hiie instanc anti inflammatori balanc impair accompani accumul metabolit relat energi suppli reduct exercis induc decreas sbp | D000397;D000076764 | T080;T069 |
34,688,751 | coupl decreas snow accumul increas light absorb particl acceler glacier retreat tibetan plateau glacier tibetan plateau tp experienc dramat retreat result serious environment ecolog consequ addit temperatur increas increas light absorb particl lap decreas precipit propos independ play import role reduc glacier accumul base investig effect extrem low precipit event tp surround region caus la nia octob april new mechan provid shown decreas precipit studi period lead low snow accumul high lap concentr snow glacier surfac tp phenomenon strong enhanc earlier acceler glacier melt critic region need consid futur relat studi | D046448;D012914 | T070 |
34,688,750 | occurr concentr size microplast highway runoff remov gross pollut trap bioretent sand filter stormwat treatment train microplast pollut stormwat serious threat environ gross pollut trap gpt bioretent treatment train shown previous treat inter alia particul stormwat pollut includ microplast particl larger studi carri investig whether stormwat treatment train also remov smaller size microplast particl highway runoff investig occurr concentr size microplast particl highway runoff polym type assign volum proport sampl nine rain event taken incom highway stormwat gross pollut trap effluent outflow bioretent system well non veget sand filter microplast analys carri use ftir ftir atr made possibl detect particl carbon black present found size microplast particl abund highway runoff concentr high variabl median particlesl minimum particlesl maximum particlesl domin polym type highway stormwat polypropylen pp ethylen propylen dien epdm rubber ethylen vinyl acet eva treatment train bioretent system treat size microplast particl signific better treatment train non veget sand filter median effluent concentr particlesl particlesl respect gpt signific impact treatment size microplast particl | D004785;D018508 | T131;T052;T057 |
34,688,749 | probabl role cutibacterium acn gut polychaet capitella teleta capitella teleta marin polychaet feed refractori diet consist sediment shown contain uniqu gut microbiota compris microbi function group involv ferment result previous studi show c teleta core gut microbiota domin propionibacteria bacteria abund worm sediment fece order test hypothesi worm nutrit benefit gut microbiota identifi genet biochem character cutibacterium acn strain former propionibacterium acn isol gut c teleta show worm isol cutibacterium acn strain primarili belong phylotyp group ib like clonal popul also provid evid test strain produc propion vitamin b essenti host requir microbi metabolit presenc c acn c teleta uniqu worm cultur also found obtain geograph distant laboratori locat us europ moreov popul worm gut associ c acn increas follow antibiot treatment collect result studi demonstr c acn member worm core function microbiota like select favor physiolog chemistri host gut environ knowledg first report presenc c acn c teleta gut data strong suggest c acn bacterium previous studi opportunist pathogen like act symbiont c teleta provid host essenti nutrient surviv growth reproduct | D000069196;D064307;D011077 | T007;T001;T032;T204;T028 |
34,688,748 | ecosystem servic valuat china meta analysi although number studi ecosystem servic valu esv steadili increas larg variat inconsist pattern estim result motiv us systemat explor factor under discrep therefor studi aim explor role differ ecosystem ess valuat method econom develop esv employ meta analysi valuat research conduct china es base observ studi result show wetland ecosystem highest valu among seven major ecosystem regul water flow servic valuabl servic also provid matrix monetari valu differ categori ecosystem servic use quick tool predict esv china assess valu chang caus land use chang find esv estim follow equival factor method differ estim method indic research care select valuat method evalu ess econom develop level differ impact differ ess gross domest product gdp per capita high posit correl recreat servic valu correl habitat servic valu | D003247;D017753 | T082;T064;T078;T081;T070;T069 |
34,688,747 | aquat toxic aquat ecolog risk assess wastewat deriv halogen phenol disinfect byproduct increas number wastewat deriv aliphat phenol disinfect byproduct dbps discharg aquat environ discharg disinfect wastewat howev current avail aquat toxic data aquat ecolog risk inform limit especi wastewat deriv phenol dbps studi investig acut toxic phenol dbps select typic five group phenol dbps trihalo phenol dihalo nitrophenol dihalo hydroxybenzaldehyd dihalo hydroxybenzo acid halo salicyl acid aliphat dbps gobiocypri rarus also assess potenti aquat ecolog risk experiment result indic half lethal concentr lc valu trihalo phenol dihalo nitrophenol rang mgl dihalo hydroxybenzaldehyd mgl dihalo hydroxybenzo acid halo salicyl acid mgl toxic mode action moa identif result three method suggest clear consist moa obtain dbps current speci specif aquat toxic analysi result highlight aquat speci would consid sensit speci dbps howev crustacean fish sensit alga test compound last aquat ecolog risk assess result dbps reveal phenol aliphat dbps bromoacetamid bromodichloromethan low aquat ecolog risk dichloroacet acid dibromoacetonitril high aquat ecolog risk low environment concentr main reason high toxic phenol dbps trihalo phenol dihalo nitrophenol exhibit low ecolog risk ecolog risk may increas increas correspond environment concentr thus effort made determin potenti harm effect high toxic phenol dbps minim potenti ecolog risk take appropri measur | D004202;D014874;D018508 | T167;T131;T052;T057 |
34,688,746 | spray drift loss agricultur road import surfac water contamin direct drift surfac water spray drift consid major pesticid transport pathway surfac water current research legisl usual consid direct spray drift howev also spray drift road subsequ wash surfac water identifi possibl transport pathway hydraul shortcut storm drainag inlet channel drain ditch shown connect road surfac water thus increas risk drift wash surfac water howev import pathway never assess larger scale address knowledg gap studi agricultur catchment predomin arabl crop n vineyard n studi site assess occurr shortcut field map afterward model area road drain surfac water use high resolut digit elev model resolut multipl flow algorithm final model drift deposit drain road surfac water use spatial explicit georeferenc spray drift model result show site drift drain road much larger direct drift surfac water arabl land site drift road exceed direct drift factor vineyard site arabl land site drift drain road rather small appli amount compar typic total pesticid loss surfac water howev substanti drift drain road vineyard site found appli amount current literatur suggest major fraction drift deposit road wash rain event especi pesticid low soil adsorpt coeffici pesticid particular vineyard spray drift wash drain road therefor expect major transport pathway surfac water | D000383;D010575 | T131;T090 |
34,688,745 | n p co dope carbon fill carbon nitrid microtub promot photocatalyt hydrogen product carbon nitrid cn photocatalyt hydrogen product catalyst attract great attent suffer poor perform due unsatisfi energi band gap low separ effici photogener carrier herein creat simpl method construct novel cn base photocatalyst ie n p co dope carbon fill cn microtub present narrow band gap high separ effici photogener carrier good stabil novel structur tubular morpholog cn ensur narrow band gap n p co dope carbon facilit transfer photogener electron coupl two reduc energi band gap improv separ effici photocatalyt hydrogen evolut visibl light optim sampl present ultrahigh hydrogen evolut rate mol g h rank top level time tradit bulk cn addit also high reusabl good stabil four cycl experi studi provid new viewpoint design develop high effici photocatalyst hydrogen product | D002244;D009570 | T121;T196;T109 |
34,688,744 | field test surfac soil moistur map use sentinel radar data soil surfac moistur one key paramet describ hydrolog state assess potenti avail water irrig plant radar backscatt coeffici sensit soil moistur applic sentinel data may support soil surfac moistur map high spatial resolut detect spatial tempor chang field scale precis irrig manag map requir control soil water eros preferenti water flow improv irrig water effici minimis negat impact surfac ground water bodi direct observ soil surfac moistur cm thick perform experiment plot studi site russian scientif research institut irrig agricultur near villag vodnyy volgograd region soil surfac moistur retriev sentinel perform locat second set soil surfac moistur calcul soil sampl site use permitt model base estim soil surfac characterist reflect obtain neural network method sentinel observ b rough obtain geodata stereoscop survey unman aerial vehicl phantom pro raster set soil surfac moistur geodata obtain base reflect geodata raster set solv invers problem use permitt model consid soil textur experiment plot determin coeffici standard deviat obtain compar set soil moistur point geodata taken soil sampl site valu confirm satisfactori linear correl direct measur indirect model set comparison two set geodata indic satisfactori reproduct first set second set result develop method consid scientif methodolog basi new technolog soil surfac moistur monitor radar one basic characterist use precis irrig manag | D011825;D012987 | T167;T073 |
34,688,743 | poor conduct biochar boost extracellular electron transfer effici volatil fatti acid oxid via redox mediat mechan studi explor perform associ mechan biochar promot volatil fatti acid vfa oxid via extracellular electron transfer eet pathway found bioelectrochem system ad biochar suspens remark enhanc electr generat whatev acet propion use electron donor maximum current densiti biochar assist group reach higher control group lower electr resist anod biochar assist group potenti attribut form biofilm domin electro activ geobacteracea electron donor type depend domin genus specif biochar assist desulfuromona enrich acet electron donor relat abund geobact increas domin genus propion ad group electrochem analysi uncov biochar hard elev sludg electr conduct excel redox base electron exchang transfer capac like made biochar transient electron acceptor access anod support metabol electroact bacteria initi stage meanwhil porous surfac area biochar particl like provid bridg suspend sludg anod support direct evolut electroact bacteria anod dual function biochar achiev sustain vfa oxid via eet base pathway | D004583;D005232 | T123;T109;T196;T081 |
34,688,742 | coupl suspect non target analyt method screen organ contamin concern agricultur urban impact water optim applic long term exposur contamin emerg concern cec may pose risk human health ecosystem even low concentr river impact agricultur urban activ experi distinct environment pressur due receiv wastewat contain complex organ transform product tps studi develop region databas compos cec high concern guangxi south china optim comprehens analyt method simultan screen cec tps optim screen method appli surfac water sampl differ cross section river impact agricultur urban activ best result method optim achiev screen detect limit sdl rang ng l analyt accept recoveri rate rang rsd cec contain region databas detect least one sampl site studi river via suspect screen among contamin found sampl site also addit contamin tps tentat identifi via non target screen among tps report first time aquat environ triazin herbicid tps identifi sampl site ametryn atrazin pose relat high risk river ecosystem furthermor known analyt select standard order confirm combin screen method one fals posit occur non target screen method accord result suspect screen strategi provid valuabl confirm identif wide rang cec water non target screen provid refer research supplement region databas particular studi tps | D014874 | T131 |
34,688,741 | sourc trace potenti toxic element soil around typic coke plant industri area northern china coke plant substanti sourc potenti toxic element ptes soil studi examin concentr ptes soil physicochem properti pb isotop soil insid around coke plant industri citi northern china analyz spatial distribut ptes pollut risk area geo index enrich factor ef nemerow index quantit identifi contribut pte pollut sourc soil small medium scale plant work section result indic hg concentr insid plant cd concentr agricultur land around plant relat high comprehens analysi soil studi area perform use posit matrix factor model pb isotop pb pb trace method base mixsiar model analysi indic burn coal main sourc pb insid outsid coke plant pollut emiss sourc signific influenc soil outsid coke plant diesel vehicl gas tank coke oven sourc insid plant quench section atmospher deposit coke oven section diesel vehicl result pte pollut risk zone pb isotop trace indic pollut serious western part plant area coke gas product take place serious pollut outsid plant main distribut southeast studi provid theoret practic data indic contribut industri enterpris soil pollut help identifi pollut respons manag pollut sourc | D003077;D012987 | T167 |
34,688,740 | quantifi impact climat dynam land use chang water yield servic agro pastor ecoton northern china larg scale reveget practic last approxim two decad agro pastor ecoton northern china aenc impact hydrolog ecolog effect remain poor understood previous studi larg focus assess water yield servic wys base sever fix time point wherea time seri inform continu wys dynam reliabl valuabl decis make water sustain goal studi analyz interannu wys trend relat role driver last year base newli propos approach reveal past present futur impact reveget wys final result indic annual wys averag approxim mm exhibit increas trend mm year p climat land use chang respons wys variat respect wys pronounc mm year p lower afforest area nonafforest area precipit two region statist insignific differ p futur reveget scenario show great potenti shrinkag wys provis even approach maximum mm local scale even afforest induc reduct blue water benefit green water receiv equal attent specif attempt assess wys climat driven ecosystem servic use discontinu year studi period must taken extrem caution | D017753;D014867 | T070;T082;T121;T197 |
34,688,739 | model simul control biolog chemic p remov process membran bioreactor mbrs lab full scale applic state art phosphorus p remov domest wastewat requir counter eutroph receiv water bodi mandat regulatori framework sever countri discharg limit within mgpl oper higher sludg retent time srt higher biomass concentr convent activ sludg process casp membran bioreactor mbrs abl remov phosphorus without addit coagul full scale facil enhanc biolog phosphorus remov ebpr assist addit metal coagul ensur p remov mbrs success use super larg scale wastewat treatment facil capac paper document knowledg p remov model lab full scale submerg mbrs assess exist mathemat model p remov domest wastewat still limit studi involv integr model mbrs fullsup larg scale consid complex interact among biolog chemic addit filtrat foul paper analys design configur paramet affect biolog chemic p remov mbrs understand p remov process sensit implic model studi furthermor thorough review applic bio kinet chemic precipit model mbrs assess effect default stoichiometr kinet paramet extent paramet calibratedadjust simul p remov success also present brief overview comparison seven chemic precipit model along quick comparison commerci avail simul addit advantag associ chemic precipit p remov role chang relat abund microbi communiti respons p remov denitrif controversi role foul mitigationincreas discuss last encompass sever coagul dose control system applic pilot full scale facil save coagul optim p remov perform | D008567;D014865 | T074;T057 |
34,688,738 | high throughput sequenc base direct detect sar cov fragment wastewat pune west india given larg number sar cov infect individu clinic detect prove challeng wastewat base epidemiolog paradigm would cover clinic escap asymptomat individu owe faecal shed virus hypothesis use wastewat valuabl resourc analys sar cov mutat circul wastewat pune region maharashtra india one affect covid pandem conduct studi open wastewat drain decemb march assess presenc sar cov nucleic acid detect mutat use artic protocol minion sequenc analysi reveal mutat across six sampl categoris type mutat report occurr mutat associ delta variant lineag march sampl simultan also report variant concern voc respons rapid increas infect studi also reveal four mutat n cr nsp cf nsp ldel current report wastewat clinic data india report worldwid novel mutat nsp gf map nsp region observ wastewat notabl pdel mutat detect decemb sampl report februari clinic data indic instrument wastewat data earli detect first studi india demonstr util sequenc wastewat base epidemiolog identifi mutat associ sar cov virus fragment wastewat earli warn indic system | D000086382;D000086402 | T047;T005;T067 |
34,688,737 | hurrican flood acut gastrointestin ill north carolina hurrican often flood home industri spread pathogen contact pathogen contamin water result diarrhea vomit andor nausea known collect acut gastrointestin ill agi hurrican matthew florenc caus record break flood north carolina nc octob septemb respect examin relationship hurrican flood agi nc first calcul percent zip code flood hurrican matthew florenc rate caus agi emerg depart ed visit calcul nc ed surveil system data use control interrupt time seri compar agi ed visit rate three week hurrican zip code third area flood predict rate hurrican occur base agi ed trend control agi ed visit rate unflood area examin altern case definit bacteri agi effect measur modif race age observ increas rate ratio rr ci agi ed visit rate hurrican matthew florenc effect particular strong among american indian patient patient age year older florenc elev among black patient hurrican florenc effect consist matthew effect possibl littl rain preced florenc heavi rain preced matthew restrict bacteri agi found rr ci increas agi ed visit rate florenc increas matthew hurrican flood associ increas agi ed visit rate although strength effect may depend total storm rainfal anteced rainfal american indian black peopl histor push less desir flood prone land may higher risk agi storm | D055867 | T070 |
34,688,736 | flood signal tree ring wood anatom paramet lagerstroemia speciosa implic develop flood manag strategi bangladesh bangladesh consist flood plain gang brahmaputra meghna river system gbm make countri one highest flood prone countri world due high rate discharg gbm caus summer monsoon snowmelt eastern himalaya southern tibetan plateau due climat chang bangladesh wit flood event perform multiproxi tree ring analysi investig impact extrem flood event tree growth xylem anatom paramet oxygen isotop composit tree ring cellulos tr bangladeshi moist tropic forest establish relationship water level region river tree ring paramet use pointer year analysi compar pointer year histor flood record cut threshold countri flood land area identifi three extrem flood event hereaft call flood year bangladesh superpos epoch analysi reveal signific chang tree ring width trw total vessel area tva vessel densiti vd tr flood year flood associ hypox soil condit reduc trw tva vari flood event contrast vd increas safeti mechan flood induc hydraul failur tree ring signific decreas flood year due amount effect region precipit bootstrap pearson correl analysi show wood anatom variabl encod stronger river level signal trw tr among wood anatom paramet vd show strong relationship r p water level manu river region river north eastern part bangladesh indic vd use reliabl proxi river level reconstruct analys suggest multiproxi tree ring analysi potenti tool studi tropic moist forest respons extrem flood event identifi suitabl proxi reconstruct hydrolog characterist south asian river | D055868;D031563 | T070;T002 |
34,688,735 | link sink interplay habitat structur ecolog constraint interact human influenc connect conserv tiger forest corridor global land use chang rapid infrastructur develop necessit identif conserv wildlif corridor connect corridor shape speci structur ecolog behavior constraint multi use landscap speci interact human could addit influenc connect use tiger panthera tigri case studi make simultan assess potenti connect habitat use examin link speci negat interact human central india assess potenti connect across sq km kanha pench forest corridor use graph theoret method combin indirect sign survey occup model examin habitat use evalu congruenc potenti connect next estim spatial probabl livestock depred applic multi state occup model interview base survey data local resid habitat use tiger negat associ forest fragment anthropogen disturb livestock depred posit associ size settlement area frequent tiger negat anthropogen disturb within forest found high congruenc connect habitat use r strong correl hold area high level livestock depred level result indic area high use tiger constrain limit connect higher chanc human tiger conflict area may ecolog trap speci interact human crucial mediat connect larg carnivor share habitat find present opportun consolid area carnivor conserv local livelihood need balanc framework also provid foundat spatial priorit incorpor plural dimens util connect conserv wide rang carnivor | D046010 | T015 |
34,688,734 | phthalat pollut migrat soil air veget system typic plastic agricultur greenhous northwestern china phthalat pollut plastic greenhous pgs arous concern howev mechan factor veget plant pgs vpgs accumul phthalat soil air unclear fill gap pgs shaanxi largest veget product provinc northwestern china select probe issu soil sampl air sampl vpg sampl collect winter summer median sum phthalat concentr pae pg soil air vpgs g kg ng g kg dri weight respect pae concentr pg environment media winter higher summer signific differ vpgs sum concentr bis ethylhexyl phthalat dehp di n butyl phthalat dnbp account pae soil vpgs dnbp dehp concentr vpgs signific correl air soil correl coeffici r air soil log transform soil air partit coeffici log k sa fugac fraction log ff dnbp decreas log k sa log ff dehp increas winter summer though dnbp soil volatil air dehp air sank soil within year issu caus air temperatur chang applic plastic film furthermor dnbp concentr vpgs posit correl k sa valu dnbp r dehp negat r therefor vpgs could uptak phthalat air soil especi edibl part leafi solanac vpgs appli phthalat free agricultur film precis manag adjust air temperatur pgs could consid ensur vpg safeti | D004051;D010795;D012989 | T131;T122;T109 |
34,688,733 | data driven applic mem base acceleromet leak detect water distribut network water scarciti global concern countri face extrem high medium high risk water stress era crisi water conserv absolut necess water distribut network wdns global experienc signific leak leak caus tremend financi loss unaccept environment hazard thus aggrav water scarciti situat minim damag adopt advanc technolog methodolog leak detect wdns absolut necessari regard investig applic cost effect mem base acceleromet experi conduct real network metal non metal pipe cours ten month acquir acceler signal analyz use monitor algorithm monitor index effici standard deviat everi leak leak case extract two individu knn decis tree two ensembl random forest adaboost decis tree base machin learn model develop accur classif leak leak case use extract featur separ model develop metal non metal pipe random forest outperform machin learn model overal accuraci reach metal pipe non metal pipe machin learn model valid use unseenunlabel case high effect detect leak studi demonstr applic mem base acceleromet leak detect establish real network base machin learn model therebi contribut research scarciti import area | D055617 | T170;T068 |
34,688,731 | infant preschool feed behavior chines famili systemat review systemat review conduct literatur feed behavior chines famili children year old forti relev public identifi publish chines english studi questionnair base use cross section research design approxim half studi report score feed practicestyl base likert scale half dichotom score percentag popul report frequent use behavior common report feed style chines caregiv local defin activ respons style somewhat resembl authorit parent common report feed practic prais encourag tri new food encourag balanc diet encourag healthi eat behavior show great deal varianc preval studi may least partial due differ methodolog behavior defin feed behavior vari frequenc depend child age although longitudin studi need better understand evolv time child bodi composit also associ feed behavior use although direct associ determin due cross section natur research still import gap literatur regard feed behavior non matern caregiv grandpar often play import role childcar china | D005247;D016487 | T040;T054;T055 |
34,688,730 | negat affect childhood advers adolesc eat follow stress obes common emerg adolesc associ serious health consequ emot eat consum calori fat sugar respons negat affect may promot obes howev evid mix whether negat affect increas obesogen eat earli life advers may shape malleabl neurobiolog system govern inhibitori control physiolog regul cope strategi eat behavior contribut greater obesogen eat respons negat affect therefor studi test whether childhood advers moder associ negat affect food consumpt divers sampl femal adolesc complet childhood advers assess femal adolesc year african american hispaniclatina non hispan white rate negat affect respons standard social stress paradigm consum buffet lunch evalu calori ad sugar solid fat consum result support negat affect exert main effect eat behavior howev negat affect childhood advers interact predict calori solid fat consum negat affect associ obesogen eat high advers exposur low advers exposur advers affect interact predict ad sugar consum find support eat pattern respons negat affect may differ childhood advers histori reduc children advers exposur bolster emot regul techniqu adolesc expos advers may provid pathway protect health well reduc maladapt eat pattern | D000076783 | T033 |
34,688,729 | predict valu evalu bias attent bias approach bias self regulatori control soft drink consumpt global consumpt soft drink increas rapid past year make major public health problem guid dual process model present studi aim provid comprehens investig role cognit bias evalu attent approach bias self regulatori control soft drink consumpt choic particip undergradu student year complet comput base measur three bias implicit associ task dot probe task approach avoid task self regulatori control gono go task soft drink consumpt choic measur use tast test take home beverag choic task respect evalu bias soft drink cue posit associ amount soft drink consum self regulatori control negat correl amount soft drink consum men interact cognit bias self regulatori control predict soft drink consumpt choic nonetheless result support applic dual process model soft drink consumpt automat evalu bias control process self regulatori control predict amount soft drink consum albeit independ certain individu futur research extend find habitu soft drink consum individu activ wish limit soft drink intak | D000070379 | T041 |
34,688,728 | alter larg scale function network adult posttraumat stress disord systemat review meta analysi rest state function connect studi posttraumat stress disord ptsd associ dysfunct larg scale brain function network reveal rest state function connect studi howev remain unclear network consist affect import role diseas trauma may play disrupt function network perform systemat review studi explor network alter use seed base function connect analysi compar individu ptsd control general well trauma expos nonexpos control specif quantit meta analysi conduct number studi appropri high found hypoconnect within default mode network dmn well affect network dmn specif associ traumat experi addit hyperconnect somatomotor network smn dmn smn specif relat ptsd result emphas effect trauma alter intrins brain network highlight diseas associ network alter may help us better understand neural mechan trauma ptsd | D013313 | T048 |
34,688,727 | effect treadmil exercis anim model parkinson diseas systemat review parkinson diseas pd progress disabl brain disord physic exercis shown allevi symptom pd consequ improv patient qualiti life exercis mechan involv benefici effect pd wide investig studi aim systemat review literatur use treadmil exercis pd anim model studi conduct accord prefer report item systemat review meta analys prisma search conduct medlin embas isi databas total studi includ dopaminerg system behavior neuroplast neuroinflamm mitochondria musculoskelet system outcom evalu select studi base systemat review center laboratori anim experiment syrcl rob tool methodolog reveal high risk bias lack inform studi design need attent data reproduc review guid futur studi aim fill exist gap regard effect treadmil exercis pd anim model | D010300 | T047 |
34,688,726 | sar cov detect air sampl insid heat ventil air condit hvac system covid surveil student dorm covid pandem affect univers institut caus campus shutdown transit onlin teach model detect infect might spread campus pursu research toward detect sar cov air sampl insid student dorm | D000086382;D000086402 | T047;T005;T067 |
34,688,725 | effect silver nanoparticl chlorin reaction time regul emerg disinfect product format silver nanoparticl agnp use mani industri multipl applic inevit releas agnp surfac water sourc format kinet disinfect product dbps presenc agnp investig chlorin experi carri raw water canal songkhla thailand analyz format potenti fp trihalomethan fp thmfp iodo trihalomethan fp thmfp haloacetonitril fp hanfp trichloronitromethan fp increas agnp concentr mgl led higher specif format rate chloroform describ zero first order kinet increas specif format chloroform increas chlorin contact time could enhanc thmfp rate maximum thmfp concentr test agnp agnp content signific influenc thmfp hanfp concentr speciat thmfp hanfp increas short chlorin time most complet format h rate decreas reaction proceed level thms mani emerg dbps relat presenc agnp chlorin water chlorin reaction time thmfp higher impact integr toxic risk valu itrv thmfp hanfp chlorin water agnp chlorin reaction time effect increas itrv thmfp level agnp water treatment plant control dbps caus possibl health risk water consumpt optim water distribut time | D004202;D053768;D014874;D018508 | T052;T057;T073;T167;T131 |
34,688,724 | remot sens framework map potenti toxic element agricultur soil humid tropic soil contamin potenti toxic element ptes one greatest threat environment degrad know ptes accumul soil mitig advers effect plant anim human health evalu potenti use long term remot sens imag reveal bare soil detect map ptes agricultur field studi soil sampl collect superfici layer cm km agricultur area locat paulo state brazil test soil synthet imag sysi use landsat tmetmetm landsat oli sentinel imag three product differ spectral tempor spatial resolut time seri multispectr imag use reveal area bare soil spectra use predictor soil chromium iron nickel zinc content observ strong linear relationship r select ptes near infrar nir shortwav infrar swir band sentinel ensembl year data landsat tm year data landsat oli year data clearest discrimin soil ptes obtain sysi use long term landsat collect year satellit data could effici detect content ptes soil due relat soil attribut parent materi therefor distinct satellit sensor could map ptes tropic assist understand spatial dynam environment effect | D012987;D012989 | T167;T131 |
34,688,723 | long term air pollut covid mortal rate california find springsumm winter surg covid grow number studi report associ air pollut covid mortal ecolog studi counti region level disregard import local variabl reli data first month pandem use covid death identifi death certif california evalu whether long term ambient air pollut relat week covid mortal census tract level first month pandem week covid mortal census tract calcul base geocod death certif data annual averag concentr ambient particul matter pm pm nitrogen dioxid ozon assess census tract use invers distanc squar weight base data ambient air qualiti monitor system negat binomi mix model relat week census tract covid mortal count natur cubic spline calendar week includ adjust potenti confound census tract demograph socioeconom factor random effect census tract counti offset census tract popul data analyz two studi period springsumm march octob winter octob march mean standard deviat concentr gm pm gm pm ppb ppb springsumm adjust rate ratio per standard deviat increas confid interv pm pm associ replic winter although attenu pm pm studi find support relat long term ambient air pollut exposur covid mortal communiti histor high pollut level might higher risk covid mortal | D000393;D000397;D000086382 | T047;T131;T067;T080;T069 |
34,688,722 | immunomodul heavi metal contribut factor inflammatori diseas autoimmun reaction cadmium exampl cadmium cd repres uniqu hazard long biolog half life human year metal accumul organ caus continuum respons organ diseasefailur extrem outcom cellular molecular alter target tissu relat immun modul potenti cd metal may caus advers respons compon immun system function mediat effector cd tissu toxic combin cd induc alter homeostat repar activ may contribut tissu dysfunct work current knowledg concern inflammatoryautoimmun diseas manifest found relat cadmium exposur summar along epidemiolog evid anim vitro data present focus cellular molecular immun mechan potenti relev diseas suscept diseas promot facilit develop pre exist patholog | D001327;D056747 | T047;T061 |
34,688,721 | earli diastol strain rate relat long term prognosi follow isol coronari arteri bypass graft ratio earli mitral inflow veloc earli diastol strain rate eesr novel echocardiograph measur estim earli left ventricular lv fill pressur hypothes eesr predictor outcom follow coronari arteri bypass graft cabg superior convent use ee | D008943;D018487 | T023;T046 |
34,688,719 | new evid direct oral anticoagul therapi cardiac valv calcif renal preserv inflammatori modul rivaroxaban direct inhibitor activ factor x fxa anti inflammatori protein exert protect effect cardiac valv vascular endothelium compar effect warfarin rivaroxaban inflamm biomark contribut heart valv calcif progress renal preserv popul atrial fibril af patient chronic kidney diseas ckd stage b | D000925;D001281;D002114;D006351;D007249;D020521 | T023;T047;T121;T046 |
34,688,718 | high flexibl porous silk fibroin microneedl wrap perivascular drug deliveri various perivascular drug deliveri techniqu demonstr local post treatment intim hyperplasia vascular inflammatori respons caus endotheli damag although perivascular devic focus control deliveri durat anti prolifer drug confin unidirect deliveri drug target tissu becom increas import addit care attent also paid lumin stabil adequ exchang vascular protein cell blood vessel extravascular tissu avoid side effect long term applic perivascular devic high flexibl porous silk fibroin microneedl wrap silk mn wrap propos direct inject antiprolif drug anastomosi site ensur suffici vascular exchang drug embed silk mns transfer mold high flexibl porous silk wrap enhanc cell compat molecular permeabl flexibl silk mn wrap guarante structur integr blood vessel silk wrap success support silk mns induc multipl mn penetr target tissu day silk mn wrap signific inhibit intim hyperplasia reduct neointim format | D016503;D005349 | T116;T074;T123 |
34,688,717 | facil prepar novel modifi biochar base supramolecular self assembl g c n enhanc visibl light photocatalyt degrad phenanthren ration design novel environment friend photocatalyt composit persist pollut remov energi product catalyt applic attract widespread interest studi new composit compos koh modifi biochar g c n differ morpholog success prepar facil supramolecular self assembl thermal poli condens method character result prepar composit suggest koh modifi biochar well combin g c n differ morpholog synthes catalyst use degrad phenanthren visibl light radiat bcg c n perform best remov phenanthren first order reaction rate constant h time higher g c n bcg c n still exhibit high photocatalyt activ four cycl radic quench result show superoxid radic hydroxyl radic oh hole h could use activ speci redox reaction phenanthren base explor result gas chromatographi mass spectromet gc ms possibl reaction pathway phenanthren degrad also propos studi provid novel strategi fabric various high perform photocatalyst remov persist organ pollut | D002606;D010616 | T121;T196;T109 |
34,688,716 | effect nano microplast kidney physicochem properti bioaccumul oxid stress immunoreact potenti toxic nanoplast nps microplast mps rais concern howev knowledg effect npsmps health mammal still limit investig alter physicochem properti polystyren nps ps nps nm mps ps mps nm nm gastrointestin tract moreov investig uptak bioaccumul toxic effect plastic particl kidney mice result reveal digest promot aggreg ps nps ps mps increas zeta potenti valu ps nps ps mps bioaccumul kidney aggreg nm ps mps exacerb biotox ps nps ps mps caus mice weight loss increas death rate signific altern sever biomark result histolog damag kidney also found exposur ps nps ps mps induc oxid stress develop inflamm find provid new insight toxic effect nps mps mice | D000080545;D014874 | T131;T122 |
34,688,715 | remov uranium vi aqueous solut anaerob digest sewag sludg hydrotherm pretreat anaerob digest ad hydrotherm ht pretreat sequenti ht ad treatment novel technolog sludg manag ht ad sludg rich function group applic pollut sorbent might win win strategi studi investig remov uranium vi water use ht ad sludg affect solut ph temperatur ion strength reusabl heavi metal risk ht ad sludg also assess batch sorption experi demonstr even acid initi ph maximum adsorpt ht ad sludg uranium vi reach mgg higher carbon base materi inner sphere sphere complex uranium vi ht ad sludg domin adsorpt ph rang respect ftir xps analysi indic primari mechan uranium vi adsorpt ht ad sludg surfac complex electr attract uranium vi function group eg coo ht ad sludg remov rate uranium vi ht ad sludg decreas consecut adsorpt cycl leach experi show less total heavi metal releas ht ad sludg research prove ht ad sludg use effici uranium vi adsorb good reusabl environment safeti | D014501 | T196 |
34,688,714 | adsorpt behavior cs natur soil batch experi model base quantif differ adsorpt site understand adsorpt behavior radiocesium rcs natur soil crucial remedi evalu radioact contamin site studi investig adsorpt behavior cs onto natur soil collect beij batch adsorpt experi sequenti extract multi site adsorpt model built quantit analyz adsorpt capac soil clay miner predict cs adsorpt ratio differ adsorpt site linear program calcul show illitesmectit mixtur illit main clay miner composit batch adsorpt experi result show soil adsorpt cesium ion exotherm process order influenc competit cation competit adsorpt strength cs k mg ca na ha humic acid littl effect soil adsorpt sem ed analysi show cs main distribut surfac ps soil particl base result adsorpt cs onto clay miner soil well predict linear program calcul multi site adsorpt model multi site adsorpt model quantit describ predict adsorpt behavior cs differ clay site soil fray edg site fes soil effect fix trace rcs higher concentr cesium ion main adsorb ps tii sequenti extract experi prove adsorpt form cesium soil trace high concentr condit | D012987;D012990 | T167;T131 |
34,688,713 | high perform electrochem sens hazard pesticid paraoxon use bivo nano dendrit equip catalyt strip paraoxon one pesticid induc toxic nervous system live organ work focus synthes catalyst bismuth vanad properti sens presenc organophosphorus compound character various character method structur studi done xrd uv spectroscopi ftir spectroscopi morpholog studi carri sem tem element analysi use xps spectra propos electrocatalyst success appli activ electrod materi modifi screen print carbon electrod electrochem sensor applic result studi indic bismuth vanad modifi electrod exhibit four electron transfer process reduct nitro group lead superior electrochem sens perform ethyl paraoxon detect limit good sensit cm excel reproduc repeat stabil select common interfer furthermor practic applic success carri use propos modifi strip determin paraoxon presenc river water sampl satisfactori result propos catalyst act desir candid rapid electrochem sensor | D010261;D010575 | T131;T109 |
34,688,703 | lanthanum chlorid induc autophagi primari cultur rat cortic neuron aktmtor ampkmtor signal pathway autophagi lysosom depend degrad pathway occur eukaryot cell autophagi ensur balanc surviv mechan cell harm stress excess weak autophagi lead abnorm function death case lanthanum la rare earth element ree damag central nervous system cns promot learn memori dysfunct howev under mechan fulli elucid la induc oxid stress inhibit nrfare aktmtor signal pathway activ jnkc jun jnkfoxo signal pathway result abnorm induct autophagi rat hippocampus addit la activ pink parkin signal pathway induc mitochondri autophagi howev relationship la autophagi rat neuron cellular level explor previous aim studi explor advers effect la primari cultur rat neuron expos mmoll mmoll mmoll mmoll lanthanum chlorid lacl result show la upregul p ampk inhibit level p akt p mtor increas level autophagi relat protein beclin lcb ii downregul express p bcl p upstream downstream intervent agent autophagi use detect autophagi flux verifi accuraci result electron microscopi result show signific increas number autophagosom lacl expos group find impli lacl inhibit aktmtor signal pathway activ ampkmtor signal pathway result abnorm autophagi primari cultur rat cortic neuron addit lacl induc neuron damag excess autophagi | D009474 | T025 |
34,688,702 | evalu flair hyperintens optic nerv optic nerv head visual paramet idiopath intracrani hypertens tflair hyperintens optic nerveopt nerv head describ sensit find idiopath intracrani hypertens use post contrast tflair imag purpos studi assess whether hyperintens non enhanc tflair imag occur like diseas patient control evalu relationship flair signal visual paramet materi method retrospect case control studi perform patient idiopath intracrani hypertens control underw orbit mri three neuroradiologist review flair imag subject evalu hyperintens signal within optic nervesopt nerv head use point likert scale quantit assess optic nerv signal use region interest perform clinic paramet extract diagnost perform evalu spearman correl calcul assess relationship flair signal visual outcom | D019586;D009898;D011559 | T033;T023;T047 |
34,688,699 | teprotumumab efficaci safeti durabl longer durat thyroid eye diseas treatment optic x studi evalu teprotumumab safetyefficaci patient thyroid eye diseas ted nonrespons experienc diseas flare | D005094;D049970 | T047 |
34,688,690 | identif character cd nile tilapia oreochromi niloticus cd type transmembran glycoprotein act pleiotrop function receptor mammalian immun respons system main present surfac cell associ immun system essenti classif b cell studi identifi cd homologu nile tilapia oreochromi niloticus open read frame oncd bp encod amino acid deduc amino acid sequenc contain signal peptid region transmembran region conserv portion cytoplasm region express analysi indic oncd exhibit constitut express test tissu highest express thymus analysi oncd transcript classifi igm igm lymphocyt anterior kidney spleen peripher blood igm lo igm hi lymphocyt peripher blood indic oncd high express igm lymphocyt especi igm hi b lymphocyt furthermor oncd express regul signific anterior kidney spleen follow challeng aeromona hydrophila streptococcus agalactia vivo vitro likewis igm b lymphocyt sort peripher blood upon stimul lps recombin oncd protein bacteria bind activ taken togeth result reveal oncd particip host defens pathogen infect may play import role tilapia b cell | D023681;D005393;D013290 | T013;T047 |
34,688,689 | transcript repress stochast gene express pattern cell fate specif develop often driven signal lineag specif cue yield high uniform reproduc outcom develop also involv mechan generat nois gene express random pattern across tissu cell sometim random choos two cell fate mechan call stochast cell fate specif process diversifi cell type otherwis homogen tissu stochast mechan extens studi prokaryot noisi gene activ play pivot role control cell fate eukaryot transcript repress stochast limit gene express generat random pattern specifi cell fate review current understand repress mechan produc random pattern gene express cell fate fli plant mice human | D018507;D018506;D010944;D014158 | T002;T045 |
34,688,688 | cell wall stress stimul activ protein kinas stkp streptococcus pneumonia lead multipl phosphoryl streptococcus pneumonia opportunist human pathogen encod singl eukaryot type serthr protein kinas stkp function counterpart protein phosphatas phpp signal enzym play critic role coordin cell divis growth pneumococci studi determin proteom phosphoproteom profil relev mutant comparison wild type provid repres dataset novel phosphoacceptor site stkp depend substrat stkp phosphoryl key protein involv cell divis cell wall biosynthesi unencapsul laboratori strain rx encapsul virul strain furthermor show stkp play import role trigger adapt respons induc cell wall direct antibiot phosphoryl sensor histidin kinas walk downregul protein walrk core regulon suggest crosstalk stkp walrk two compon system analysi proteom profil led identif gene cluster regul catabolit control mechan indic tight coupl carbon metabol cell wall homeostasi imbal steadi state protein phosphoryl mutant well antibiot treatment accompani accumul global spx regul indic spx mediat envelop stress respons summari stkp relay perceiv signal cell wall status key cell divis regulatori protein control cell cycl cell wall homeostasi | D013312 | T121;T039;T046;T032;T040 |
34,688,685 | vitro model charg particl therapi uncertainti opportun radiat therapi critic compon oncolog manag half cancer patient requir radiotherapi point diseas cours last decad increas interest charg particl therapi due advantag physic radiobiolog properti therapeut use proton beam therapi pbt expand worldwid howev remain larg gap knowledg radiobiolog mechan underli key aspect pbt variat relat biolog effect rbe radioresist dna damag respons repair pathway well immunolog effect addit emerg techniqu ultra high dose rate flash radiotherapi potenti reduc normal tissu toxic excit develop depth studi need postul biochem mechan underpin flash effect oxygen deplet hypothesi well relat contribut immun respons tumor microenviron investig also requir ensur flash effect diminish lost pbt current method evalu biolog effect charg particl therapi reli heavili cell cultur system andor anim model howev method well recogn limit limit translat find bench bedsid advent novel three dimension vitro tumor model offer physiolog relev high throughput vitro system studi tumor develop well novel therapeut approach pbt advanc cell cultur method togeth knowledg diseas mechan biomark genom data use design person model close recapitul tumor microenvironment factor promot particular diseas phenotyp move model pbt age precis medicin | D011829 | T081 |
34,688,683 | erythrocyt membran camouflag gefitinibalbumin nanoparticl tumor imag target therapi lung cancer convent chemotherapeut drug may caus serious side effect hepatotox renal toxic due lack target affect therapi outcom prognosi patient therefor biomimet nanoparticl long blood circul activ target attract increas attent work fabric biomimet r rbc gef nps nano system encapsul gefitinib load albumin nanoparticl gef nps insid crgd modifi red blood cell rbc membran complet rbc membran structur membran protein enabl nps escap phagocytosi macrophag addit crgd moieti signific improv tumor cell target uptak r rbc gef nps inhibit growth cell vitro dose time depend manner induc apoptosi cell cycl arrest g phase likewis r rbc gef nps also decreas tumor weight volum mice inject cell prolong surviv time addit tc label r rbc gef nps select accumul tumor tissu vivo enabl real time tumor imag final blood histolog analys show r rbc gef nps caus obvious system toxic taken togeth biomimet r rbc gef nps promis therapeut formul treatment lung cancer | D004337 | T122 |
34,688,682 | composit structur elucid bovin milk glycosaminoglycan anti adipogen activ via modul ppar cebp structur function relat glycosaminoglycan bovin milk bmgag studi detail present studi bmgag isol structur character chondroitin sulphat one major gag present di disb glca galnac follow di hexua galnac bmgag exhibit mark anti adipogen effect l cell without affect cell viabil concentr use triglycerid content treat bmgag signific decreas assess oil red stain peroxisom prolifer activ receptor ppar ccaatenhanc bind protein cebp critic transcript factor adipogenesi show signific decreas gene protein level sterol regulatori element bind protein c srebp c promot adipocyt differenti enhanc activ ppar invers affect bmgag fatti acid synthas fas express modul thus present work among first demonstr anti adipogen activ bmgag modul adipogenesi relat marker protein henc bmgag may use supplementtherapeut manag obes | D006025;D009765 | T047;T121;T109;T123 |
34,688,678 | dual respons nisin load chondroitin sulfat nanogel treatment bacteri infect soft tissu chondroitin sulfat nisin nanogel cs n ngs prepar electrostat interact nisin deliveri antibacteri agent treatment bacteri infect caus clinic strain methicillin resist methicillin sensit staphylococcus aureus aureus physic properti cs n ngs evalu use fourier transform infrar spectroscopi dynam light scatter field emiss scan electron microscopi averag diamet obtain cs n ngs nm stabil nanogel assess zeta potenti measur enzym ph respons cs n ngs due presenc suscept bond chondroitin sulfat result effect control releas nisin simul infecti medium also abil prepar cs n ngs erad clinic methicillin resist aureus strain confirm broth microdilut method bmd cytotox analysi carri human dermal fibroblast hdf cell mtt assay method base result versatil drug carrier could effici deliv cation antimicrobi peptid natur antibiot growth inhibit methicillin resist aureus strain destroy bacteria treatment subcutan infect caus methicillin resist aureus strain | D000080385 | T122 |
34,688,677 | structur character water solubl polysaccharid angelica dahurica antitumor activ h tumor bear mice novel angelica dahurica polysaccharid adp mw da isol content total sugar uron acid adp structur characterist indic adp acid polysaccharid consist rhamnos arabinos galactos glucos mannos glucuron acid galacturon acid moreov manp galp galp glcp araf galp adp relat molar ratio vivo experi suggest adp signific inhibit tumor growth mice increas activ spleen lymphocyt natur killer nk cell improv cytokin level il tnf proport lymphocyt subset peripher blood tumor cell progress arrest g phase apoptosi rate tumor cell dose mgkg consist result patholog observ summari studi might provid theoret basi applic function food contain angelica dahurica polysaccharid | D000970;D011134 | T121;T109 |
34,688,671 | depress symptom chronic lung diseas middl age older chines adult prospect bidirect associ mediat analysi investig prospect bidirect associ depress symptom chronic lung diseas cld explor biolog behavior relev mediat bidirect associ among chines middl age older popul china health retir longitudin studi | D003863;D008171 | T048;T047;T184 |
34,688,670 | inspiratori muscl weak cardiovascular diseas implic cardiac rehabilit exercis limit cardin manifest mani cardiovascular diseas cvd associ poor prognosi increas well understood exercis base cardiac rehabilit cr intervent portend favor clinic outcom includ improv exercis capac etiolog exercis limit cvd multifactori typic govern termin sensat pain fatigu andor breathless known perhap underestim complic cvd contribut breathless exercis intoler patient inspiratori muscl dysfunct exampl inspiratori muscl dysfunct encompass loss muscl mass andor pressur generat capac occur patient chronic heart failur associ breathless exert intoler wors surviv patient popul review defin inspiratori muscl weak detail preval rang cvds discuss inspiratori weak impact physiolog function clinic outcom patient cvd often refer cr also evalu avail evid address effect exercis base cr without concurr specif inspiratori muscl train imt inspiratori muscl function general physiolog function clinic outcom patient cvd final consid whether assess global respiratori muscl function becom standard part patient intak assess phase ii cr program give practic guidanc implement measur well imt part phase ii cr | D000072038;D002318 | T047;T061 |
34,688,669 | transcathet valv valv implant degener surgic aortic mitral bioprosthesi current state futur perspect use bioprosthet valv treat patient sever valv diseas increas last decad consequ grow number patient fail surgic bioprosthesi expect near futur set valv valv viv transcathet aorticmitr valv replac tavr tmvr emerg altern redo surgeri despit increas experi viv procedur develop techniqu face sever specif challeng main relat uniqu anatom physiolog characterist viv tavrtmvr subsequ various approach propos overcom viv relat complic pitfal grow bodi evid current avail concern earli long term clinic outcom patient undergo viv tavrtmvr data comprehens evalu heart team decis make process involv patient fail surgic bioprosthes review aim delin technic challeng risk associ viv tavr viv tmvr provid updat overview main clinic result summar futur perspect evolv field | D001024;D001705;D006350;D019918 | T074;T047;T061 |
34,688,666 | identif substrat like cleavag resist thrombin inhibitor saliva flea xenopsylla cheopi salivari gland flea xenopsylla cheopi vector plagu bacterium yersinia pesti express protein peptid thought target hemostat inflammatori system mammalian host past transcriptom analys salivari gland tissu reveal presenc two similar peptid xc xc extens similar deposit sequenc show peptid specif inhibit coagul plasma amidolyt activ thrombin xc smaller two peptid fast tight bind inhibitor thrombin dissoci constant less pm xc exhibit similar select well kinet bind properti crystal structur xc complex thrombin show despit substrat like bind mode xc detect cleav thrombin interact thrombin surfac enzym catalyt site fibrinogen bind exosit low rate hydrolysi verifi solut experi xc show substrat larg intact h incub thrombin c low rate xc cleavag thrombin may attribut specif chang catalyt triad observ crystal structur complex extens interact prime site may stabil bind cleavag product base increas arteri occlus time tail bleed time blood coagul paramet rat model thrombosi xc could valuabl anticoagul | D013917 | T116;T121;T126 |
34,688,664 | regul mitochondri cargo select autophagi posttransl modif mitochondria import organell eukaryot turnov qualiti control mitochondria regul transcript posttransl level sever cellular mechan remov defect mitochondri protein mediat mitochondria resid proteas proteasom degrad individu protein clearanc bulk mitochondria occur via select form autophagi term mitophagi yeast develop metazoan cell eg oocyt reticulocyt mitochondria larg remov ubiquitin independ mechan case regul mitophagi mediat via phosphoryl mitochondria anchor autophagi receptor hand ubiquitin depend recruit cytosol autophagi receptor occur situat cellular stress diseas dysfunct mitochondria would caus oxid damag mammalian cell well studi ubiquitin depend mitophagi pathway induc mitochondri depolar regul mitochondri protein kinas pink upon activ recruit ubiquitin ligas parkin review mechan mitophagi emphasi posttransl modif regul various mitophagi pathway describ autophagi compon involv particular emphasi posttransl modif detail phosphoryl mediat pink parkin mediat ubiquityl mitochondri protein modul deubiquityl enzym also discuss role accessori factor regul mitochondri fissionfus interplay pro antiapoptot bcl famili member comprehens knowledg process mitophagi essenti understand vital mitochondri turnov health diseas | D063154;D063306;D015398;D054875 | T043;T044 |
34,688,663 | intrins kinas activ brd span bd b bid domain bromodomain protein brd transcript epigenet regul therapeut target mani cancer inflammatori diseas brd play import role transcript activ kinas phosphoryl carboxi termin domain ctd rna polymeras ii pol ii proto oncogen c myc transcript factor taf cdk brd also passiv scaffold recruit transcript factor despit well establish function littl character brd biophys properti kinas activ report kd mous brd exist extend dimer conform sediment coeffici high friction ratio delet conserv b motif aa disrupt brd dimer brd kinas activ map amino acid span bromodomain b motif bid domain bd b bid contribut vivo phosphoryl substrat assess analyt ultracentrifug brd direct bind purifi pol ii ctd import conserv motif brd essenti phosphoryl pol ii ctd phosphoryl taf map bind site motif peptid viral mlv integras mlvin protein cellular histon lysin methyltransferas nsd shown nmr bind extra termin et domain also phosphoryl brd thus brd multipl distinct substrat bind site common kinas domain result provid new insight structur kinas function brd | D055503 | T067 |
34,688,662 | natur occur cancer associ mutat disrupt oligomer activ protein arginin methyltransferas prmt protein arginin methyl posttransl modif catalyz protein arginin methyltransferas prmt enzym famili dysregul protein arginin methyl link cancer varieti human diseas prmt predomin prmt isoform mammalian cell act pathway regul transcript dna repair apoptosi cell prolifer prmt dimer format requir methyltransferas activ mediat interact structur call dimer arm one monom surfac rossman fold monom given link prmt dysregul diseas link prmt dimer activ search catalogu somat mutat cancer cosmic databas identifi potenti inactiv mutat occur prmt dimer arm identifi three mutat correspond wl yn mv substitut human prmtv isoform wl yn mv rat prmtv use combin site direct mutagenesi analyt ultracentrifug nativ page activ assay found conserv substitut surpris disrupt oligom format substanti impair adenosyl l methionin adomet bind methyltransferas activ molecular dynam simul suggest substitut introduc novel interact within dimer arm lock conform conduc dimer format find provid clear putat rational contribut mutat impair arginin methyl cell correspond health consequ | D056004;D020125;D009369;D011484;D012097 | T044;T191;T116;T066;T045;T123;T126 |
34,688,659 | neuron specif ablat eifa deoxyhypusin synthas lead impair growth viabil neurodevelop cognit function mice eukaryot initi factor eifa essenti protein requir uniqu amino acid hypusin activ hypusin form exclus eifa post translate via two enzym deoxyhypusin synthas dhps deoxyhypusin hydroxylas gene encod protein eifa dhps dohh requir mous embryon develop variant eifa dhps recent identifi genet basi under certain rare neurodevelopment disord human investig role eifa dhps brain develop generat four condit ko mous strain use emx cre camka cre strain examin effect tempor region specif delet eifa dhps condit delet dhps eifa emx promotor driven cre express e cortex hippocampus led gross defect forebrain develop reduc growth prematur death hand condit delet dhps eifa camka promot driven cre express postnat main ca region hippocampus lead global development defect rather ko anim exhibit sever impair spatial learn contextu learn memori subject morri water maze contextu learn test model dhps ko mice display sever impair eifa ko counterpart observ defect brain global develop cognit function like result translat error due defici activ hypusin eifa studi underscor import role eifa dhps neurodevelop | D003071;D055495 | T040;T041 |
34,688,657 | intellectu disabl associ mutat ceramid transport protein gene cert lead aberr function subcellular distribut lipid molecul ceramid transport endoplasm reticulum golgi apparatus sphingomyelin product via ceramid transport protein cert encod cert hyperphosphoryl cert serin repeat motif srm decreas function form inherit intellectu disabl id associ serin leucin substitut srm sl mutat glycin arginin substitut outsid srm gr mutat cert howev unclear mutat outsid srm disrupt control cert function current investig identifi new cert variant dupaa patient mild id result frameshift c terminus cert howev famili analysi reveal dupaa variant associ id allow us util diseas match negat control cert variant associ id biochem analysi show gr sl dupaa impair srm hyperphosphoryl render cert variant excess activ addit sl gr mutat dupaa caus protein distribut punctat subcellular manner basi find infer major id associ cert variant may impair srm phosphoryl depend repress result increas sphingomyelin product concurr cert subcellular redistribut | D020125;D021381 | T043;T044;T045 |
34,688,656 | mechanist role tyrosin phosphoryl revers amyloid autoinhibit endosom membran associ alix human apoptosi link gene interact protein x alix versatil adapt protein regul essenti cellular process shuttl late endosom membran cytosol determin interact src kinas investig molecular basi transit effect tyrosin phosphoryl interplay structur assembl intramolecular intermolecular interact alix evidenc transmiss electron microscopi fluoresc circular dichroism spectroscopi prolin rich domain alix encod bind epitop multipl cellular partner form rope like sheet rich revers amyloid fibril dissolv upon src mediat phosphoryl restor protein tyrosin phosphatas b mediat dephosphoryl conserv tyrosin residu analys bro domain alix solut nmr spectroscopi elucid conform chang origin phosphoryl src establish bro bind hyperphosphoryl prolin rich domain analog late endosom membran via high basic surfac result uncov autoinhibit mechan reloc alix cytosol divers role play tyrosin phosphoryl cellular membran function alix | D000682;D002135;D018797;D056827;D011992;D007425 | T192;T116;T026;T123 |
34,688,655 | sialidas neu direct interact juxtamembran segment cytoplasm domain mucin inhibit downstream pik akt signal extracellular domain ed membran span sialoglycoprotein mucin muc vivo substrat lysosom sialidas neuraminidas neu engag muc ed cognat ligand pseudomona aeruginosa express flagellin increas neu muc associ neu mediat muc ed desialyl unmask cryptic bind site ligand howev mechan intracellular neu might physic interact surfac express muc ed substrat unclear use reciproc coimmunoprecipit vitro bind assay human airway epitheli cell system show neu associ muc cytoplasm domain cd muc ed prior pharmacolog inhibit neu catalyt activ use neu select sialidas inhibitor c butyl amid deoxi dehydro n acetylneuramin acid diminish neu muc cd associ addit glutathion transferas gst pull assay use delet mutant muc cd map neu bind site membran proxim aa muc cd cell free system found purifi neu interact immobil gst muc cd purifi muc cd associ immobil xhis neu indic neu muc cd interact direct independ chaperon protein protect proteincathepsin howev neu muc cd interact requir neu mediat muc ed desialyl final demonstr overexpress either wt neu catalyt dead neu gv mutant diminish associ establish muc cd bind partner pik muc cd reduc downstream akt kinas phosphoryl result indic neu associ juxtamembran region muc cd inhibit pik akt signal independ neu catalyt activ | D015398 | T043;T044 |
34,688,654 | kras regul kinom identifi wee erk coinhibit potenti therapeut strategi kras mutant pancreat cancer oncogen kras drive cancer growth activ divers signal network fulli delin set establish system wide profil kras regul kinas signal network kinom kras mutant pancreat ductal adenocarcinoma pdac knock kras express panel six cell line appli multiplex inhibitor beadm monitor chang kinas activ andor express hypothes deplet kras would result downregul kinas requir kras mediat transform upregul kinas could potenti compens deleteri consequ loss kras identifi upregul downregul kinas common across panel cell line agreement hypothesi upregul kinas establish role cancer driver eg src tgf ilk pharmacolog inhibit one upregul kinas ddr suppress pdac growth interest downregul kinas establish driver role cell cycl progress particular mitosi eg wee aurora plk consist crucial role downregul kinas promot kras driven prolifer found pharmacolog inhibit wee also suppress pdac growth unexpect paradox activ erk upon wee inhibit led us inhibit wee erk concurr caus potent growth suppress enhanc apoptot death compar wee inhibit alon conclud system wide delin kras regul kinom identifi potenti therapeut target kras mutant pancreat cancer | D021441;D009154;D010190;D016283 | T191;T116;T126;T045 |
34,688,653 | identif difructos dianhydrid synthasehydrolas oral bacterium establish novel glycosid hydrolas famili fructooligosaccharid anhydrid wide use health promot food prebiot various enzym act fructofuranosyl linkag natur fructan polym use produc function compound howev enzym hydrolyz form fructofuranosyl linkag less studi identifi bbde gene product bifidobacterium dentium fructofuranosidas difructos dianhydrid synthasehydrolas bifidobacterium dentium ffase enzym fructofuranosidas arabinofuranosidas activ anom retain manner ffase homolog known enzym suggest member novel glycosid hydrolas famili caramel fructos sugar incub ffase convers frup fruf fruf frup diheterolevulosan ii fruf fruf inulobios fruf fruf difructos dianhydrid dfa observ reaction equilibrium inulobios dfa bias toward latter promot intramolecular dehydr condens reaction thus name enzym dfa synthasehydrolas crystal structur ffase complex fruf araf determin resolut model dfa molecul activ site mutat analysi also identifi critic residu catalysi substrat bind hexamer structur ffase reveal connect catalyt pocket larg intern caviti via channel molecular dynam analysi impli stabl bind dfa inulobios activ site surround water molecul taken togeth result establish dfa synthasehydrolas member new glycosid hydrolas famili gh | D008958 | T170 |
34,688,651 | atrial function paroxysm af patient without heart failur preserv eject fraction data af risk studi atrial fibril af heart failur preserv eject fraction hfpef cardiovascular condit often coexist strain phase left right atria impair paroxysm af patient hfpef without hfpef spite compar global longitudin strain left ventricl atrial function may differenti paroxysm af patient hfpef without hfpef | D001281;D006333 | T047;T046 |
34,688,650 | real world antithrombot treatment variabl patient undergo peripher vascular intervent insight vqi registri undergo peripher vascular intervent pvi guidelin indic use dual antiplatelet therapi dapt reason class iib recommend reach highest level evid largest effort date found antithrombot prescript domin singl antiplatelet therapi sapt pvi switch dapt follow pvi patient still remain therapi high site variabl prescript rate median odd ratio confid interv much explain patient provid factor reveal need creation integr newest trial data intervent health system practic level help physician determin optim medic therapi follow pvi | D005343;D010975 | T121 |
34,688,649 | cardiovascular risk factor profil north south indian pakistani american masala studi south asian unit state disproportion high burden cardiovascular diseas compar raceethn group heterogen popul evalu differ preval adjust odd cardiovascular risk factor includ diabet hypertens dyslipidemia obes north indian south indian pakistani immigr unit state mediat atherosclerosi south asian live america masala studi given cultur differ among resid indian region exampl dietari pattern categor indian particip north south indian particip north indian women south indian women pakistani women unadjust diabet obes preval highest pakistani particip respect hypertens preval highest north indian particip dyslipidemia preval highest south indian pakistani particip south indian particip higher odd dyslipidemia ci compar north indian particip fulli adjust model differ cardiovascular risk factor observ across south asian american subgroup identifi determin suboptim cardiovascular health within south asian american subgroup may help better tailor cardiovascular diseas prevent strategi | D050197;D002318 | T047;T046 |
34,688,648 | sustain green nanoadsorb remedi pharmaceut water wastewat critic review last three decad pharmaceut research increas tremend offer safe healthi life howev high consumpt harm drug risen devast impact ecosystem therefor worldwid paramount concern effect clean pharmaceut contamin water stream ensur safer environ healthier life nanotechnolog enabl produc new high technic materi membran adsorb nano catalyst function surfac coverag reagent effect water wastewat cleanup process nevertheless nano sorbent materi regard appropri treatment technolog water wastewat facil applic larg number adsorb sever convent techniqu oper domest wastewat treatment ineffici pharmaceut remov altern adsorpt techniqu play pivot role water wastewat treatment long rise attract proport continu emerg new micropollut aquat environ new discoveri sustain low cost adsorb recent advanc adsorpt techniqu wastewat treatment nanoadsorb great increas due low product cost sustain better physicochem properti high remov perform pharmaceut herein review critic evalu perform sustain green nanoadsorb remedi pharmaceut pollut water influenti sorption paramet interact mechan also discuss moreov futur prospect nanoadsorb remedi pharmaceut also present | D014874;D018508 | T131;T052;T057 |
34,688,647 | associ patern serum dioxin like polychlorin biphenyl concentr ivf success pilot studi dioxin like polychlorin biphenyl dl pcbs environment pollut associ impair semen qualiti howev research potenti impact patern exposur dl pcbs risk advers pregnanc outcom limit examin relationship serum dl pcb concentr ivf outcom among male seek fertil treatment concentr serum dl pcbs analyz high resolut gas chromatographi coupl high resolut mass spectrometri modifi poisson regress adjust confound use assess bivari associ estim risk ratio rrs dl pcbs binari ivf outcom median concentr th th percentil sum dl pcbs dl pcbs obtain patient ngg lipid statist signific associ dl pcb level embryo qualiti found howev men high serum pcb concentr present probabl high qualiti embryo rr ci wherea opposit trend observ men lower serum level pcb rr ci present increas odd high qualiti embryo serum concentr pcb pcb associ decreas implant rate p moreov pcb non ortho pcbs signific associ lower likelihood clinic pregnanc p lower likelihood live birth associ higher level pcb pcb pcb record signific differ non ortho pcbs mono ortho pcbs dl pcbs p find suggest patern dl pcb exposur concept may relat pregnanc endpoint howev dl pcb measur limit male partner therefor propos futur studi larger popul size includ matern patern factor | D004147;D004785;D011078 | T131;T109 |
34,688,646 | goethit modifi biochar simultan mitig arsenic cadmium accumul paddi rice oryza sativa l cadmium cd arsenic contamin paddi soil serious global issu opposit geochem behavior cd paddi soil rice plant oryza sativa l cultiv cd contamin paddi soil regard one main dietari caus cd entri human be studi aim determin impact goethit modifi biochar gb bioavail cd cd pollut paddi soil contrari control biochar bc amend applic gb amend signific imped accumul cd rice plant result confirm obvious reduct cd content rice grain respect soil supplement gb amend bc applic minim cd uptak rice grain compar control exhibit littl impact accumul rice grain sequenti extract result display increas immobil cd fraction soil decreas bioavail fraction element gb treatment fe plaqu format root surfac signific variabl p among amend gb treatment signific increas fe content g kg root fe plaqu ultim enhanc sequestr cd fe plaqu minim transport cd rice plant moreov gb treatment signific chang relat abund microbi communiti rice rhizospher minim metal loid mobil soil relat abund acidobacteria firmicut verrucomicrobia increas gb treatment bacteroidet choloroflexi decreas find confirm improv rice grain qualiti regard enhanc amino acid content gb applic overal result studi demonstr gb amend simultan allevi cd concentr edibl part rice plant provid new valuabl method protect public health effect remedi co occurr cd paddi soil | D001151;D012275;D012989 | T121;T002;T168;T131;T196 |
34,688,645 | silicon base addit heavi metal remedi soil toxicolog effect remedi techniqu perspect chemic fertil gain increas attent center much research indic complex benefici harm effect chemic fertil might caus environment hazard biospher especi agricultur ecosystem applic silicon si fertil agricultur prove abl creat good econom environment benefit si second abund earth crust element si fertil improv soil qualiti allevi biotic abiot crop stress great signific understand function si fertil agricultur util environment remedi paper review si base fertil farmland use summar prior research relev character soil qualiti improv pollut remedi effect use agricultur enhanc plant silicon uptak mediat plant salt drought stress remedi heavi metal al cd cu zn cr articl also summar detoxif mechan silicon effect plant physiolog activ photosynthesi transpir fertil materi crop fertil manag also consid foliar spray effect method improv crop growth yield reduc biotic abiot stress silicon nanoparticl materi provid potenti great potenti prospect investig research prospect better understand silicon impact environ whether benefici addit | D019216;D012989 | T131;T196 |
34,688,644 | pretreat sludg sodium iron chlorophyllin h enhanc bioga product anaerob digest studi investig novel sodium iron chlorophyllin h sic h sludg pretreat strategi anaerob digest enhanc methan product effici mechan propos strategi enhanc sludg biodegrad explor sic h pretreat could enhanc oxid perform sludg floc disintegr dissoci tb ep ep increas scod mgl increas solubil releas ep pretreat facilit bioga product l kg vs fold control signific higher pretreat result excit emiss matrix parallel factor eem parafac analysi show sic h pretreat enhanc dissoci tb ep fraction especi protein like solubl microbi product like substanc electron paramagnet reson epr result provid evid homolyt catalysi h generat oh product high valent por fe iv intermedi synergist effect reactiv oxygen speci oh h ho por fe iv enhanc ep disintegr sic h pretreat mix acid type ferment provid continu vfas suppli enrich chloroflexi actinobacteria multipl methanosaeta also promot methan product research provid feasibl pretreat strategi increas sludg biodegrad enhanc bioga product anaerob digest process | D056804;D012722 | T069;T109 |
34,688,643 | regulatori academ studi deriv refer valu human health case bisphenol close structur analog bisphenol bp bpa recogn endocrin disrupt chemic substanc high concern european union highlight need assess extent similar two compound care scrutin bps potenti toxic human health analysi aim investig human health toxic data regard bps find point departur deriv human guidanc valu systemat transpar methodolog appli determin whether european intern refer valu establish bps absenc valu scientif literatur human health effect evalu focus human epidemiolog anim experiment studi result analyz target organsystem male femal reproduct mammari gland neurobehavior metabolismobes academ experiment studi analyz compar regulatori data includ subchron studi extend one generat reproduct studi contrast regulatori studi perform dose level mgkg bwday rang academ dataset specif target organ system show advers effect bps much lower dose gkg bwday larg dispar lowest observ advers effect level loael deriv regulatori academ studi observ bps bpa toxicokinet data bps anim human studi also analyz show fold higher oral bioavail compar bpa pig model similar differ two bisphenol particular higher bioavail bps activ non conjug form potenti impact human health discuss base avail experiment data better human protect propos deriv human refer valu exposur bps n l oael determin academ studi | D052244;D013450 | T131;T039;T121;T109 |
34,688,642 | eco friend wood adhes base waterborn polyurethan graft gelatin deriv chromium shave wast environment friend wood adhes develop waterborn polyurethan wpu graft gelatin g investig research first g extract chromium shave wast mix prepolym emuls wpu synthesi graft copolym wpug via solvent free emuls copolymer synthes copolym character use mechan properti test tga ft ir analysi technolog result indic wpug good overal perform specif contact angl reach tensil strength reach mpa temperatur maximum weight loss greater c wpug adhes excel bond power mechan properti dri bond strength reach mpa ratio free amino group g isocyan group wpu r valu prepar graft copolym satisfi need environ friend wood adhes also effect improv recycl chromium shave wast | D000269;D011140 | T167;T122;T073;T109 |
34,688,641 | honey bee biomonitor variabl element composit individu bee homogen pool sampl honey bee alreadi use monitor metal pollut environ coupl decad first studi analyz element composit individu honey bee one apiari hive use test hive hive differ locat highest hive variabl observ al x li x v x x cd x element cu k mg na p zn smallest hive x x x x x x x respect well hive variabl x x x x x x x respect observ nonetheless hive variabl statist signific analyz element prove differ signific influenc comparison element concentr bee differ locat one hive mesi apiari signific lower concentr al hive mg kg u hive mg kg time differ hive apiari show higher concentr element al hive mg kg u hive mg kg compar anoth locat thermal power plant al mg kg u mg kg therefor use honey bee biomonitor recommend larger number hive sampl locat provid adequ dataset reliabl interpret result compar individu bee element concentr na mg p k fe cu zn negat correl found dri mass bee concentr element negat correl could consequ higher honey nectar content sampl bee howev also consid use honey bee bioindic | D006722 | T168 |
34,688,640 | understand chang biocrust communiti follow phosphat mine negev desert biocrust key ecosystem engin destroy due anthropogen disturb trampl agricultur mine hyper arid region negev desert phosphat mine six decad alter natur landscap larg spatial scale recent year restor orient practic mandat mine site howev impact practic ecosystem particular biocrust layer test evalu post mine biocrust bacteri communiti compar undisturb refer biocrust collect sampl four mine site restor differ year correspond refer site hypothes post mine bacteri communiti would differ signific refer communiti given slow regener biocrust also hypothes bacteri communiti would vari among post mine plot base restor age test hypothes assess abund divers bacteri communiti sequenc rdna photosynthet potenti quantifi abund cyanobacteria chlorophyl bacteri divers lower communiti composit differ signific post mine refer biocrust addit cyanobacteria abund chlorophyl content lower post mine biocrust indic lower photosynthet potenti howev signific chang bacteri communiti detect regardless restor age suggest practic implement negev mine may support recoveri biocrust bacteri communiti particular cyanobacteria thus activ restor measur need acceler regener time biocrust hyper arid negev mine | D000458;D017753 | T070;T007;T082 |
34,688,639 | global transmiss new coronavirus variant coronavirus diseas covid caus tremend loss world studi address impact diffus five major new coronavirus variant name alpha beta gamma eta delta lineag result studi indic africa europ affect new coronavirus variant compar contin compar analysi indic vaccin contain spread virus contin non pharmaceut intervent npis restrict gather close public transport effect curb pandem especi dens popul contin accord global predict system covid pandem diffus delta lineag us show season oscil characterist first wave occur octob record follow small resurg april record second wave reach case octob studi rais awar new coronavirus variant among public help govern make appropri direct cope new coronavirus variant | D000086382;D058873 | T047;T067 |
34,688,638 | short term chang meteorolog condit suicid systemat review meta analysi suicid lead caus death particular young adult suicid behaviour influenc wide rang person social cultur factor emerg evid suggest daili chang meteorolog condit includ temperatur increas risk suicid | D013405 | T033 |
34,688,637 | review role differ ephrin glioma glioma tumor glial cell common malign tumor brain ephrin protein ligand act tyrosin kinas receptor famili eph receptor glioma invers relationship identifi ephrin ligand epha receptor ie decreas express ephrin increas express epha forc express ephrin decreas prolifer glioma intern epha receptor ligand ephrin independ effect epha receptor oncogen natur bind epha ephrin decreas glioma prolifer increas epha may import enhanc cellular prolifer migrat glioblastoma fgfr mapk akt signal pathway decreas express epha may crucial increas cellular prolifer thus ephrin act tumor suppressor glioma negat regul express egfr higher express level ephb ligand ephrin b may decreas cell adhes increas invas capac glioma hif ephb paxillin signal also key role ephrin b ephb promot migrat invas confer resist glioma cell ephrin b contribut pathogenesi glioma promot angiogenesi vegf increas ephrin b may also import increas tumorigen glioma present review describ role differ ephrin pathogenesi glioma | D036342 | T116;T123 |
34,688,635 | kdmd inhibit transcript activ fkbp suppress express ef colorect cancer male colorect cancer crc remain frequent diagnos malign also major contributor cancer relat death throughout world first reveal role histon lysin specif demethylas kdmd crc male kdmd express tumor adjac tissu male crc patient investig use immunohistochemistri rt qpcr correl express patient prognosi analyz downregul kdmd crc patient associ poor prognos overexpress kdmd signific inhibit growth metastasi crc vitro vivo downstream mechan kdmd crc investig use bioinformat analysi regulatori relationship confirm chip qpcr luciferas report assay kdmd suppress ef express mediat hkme demethyl ef high express crc promot express fkbp transcript level bind fkbp promot final rescu experi reveal overexpress fkbp signific revers inhibitori effect kdmd crc growth metastasi collect kdmd exert anti tumor anti metastat crc demethyl ef suppress fkbp transcript might repres novel target crc treatment male | D015972 | T045 |
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