PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,687,852 | evalu potenti multi parametr mri use co regist histolog applic mous model glioblastoma convent mri fail detect region glioblastoma cell infiltr beyond contrast enhanc solid tumor region infiltr tumor cell often migrat along host blood vessel | D005909;D000081364 | T191;T060 |
34,687,851 | novel techniqu autom stiff measur emphas main wave coher wave auto select chase studi aim develop assess new autom process techniqu mr elastographi mre name coher wave auto select chase chase enabl automat select region interest roi stiff measur extract coher wave region chase roi improv reconstruct stiff direct filter orient along main wave pixel chase filter studi mre phantom liver four healthi volunt perform investig potenti chase studi assess chase accord three indic phantom studi agreement roi set chase expert observ nois depend effect chase stiff variabl within chase roi agreement roi set analyz cohen kappa coeffici nois depend analyz mean absolut percentag error mape within roi low amplitud high vibrat amplitud amplitud stiff variabl assess standard deviat sd within roi volunt studi agreement roi set stiff valu stiff variabl within chase roi assess use valu intraclass correl coeffici icc coeffici variat respect result show close agreement roi set stiff valu greater phantom volunt studi icc volunt studi mape within chase roi much smaller whole region phantom chase roi vs whole region amplitud vs moreov phantom volunt studi stiff variat within chase roi smaller elastogram process chase filter unprocess one result demonstr chase high robust nois potenti provid roi set stiff measur compar expert observ well improv reconstruct stiff | D054459 | T060 |
34,687,850 | mri base machin learn determin quantit qualit characterist affect surviv glioblastoma multiform current studi aim consid imag biomark extract mri imag explor effect glioblastoma multiform gbm patient surviv determin biomark help better manag diseas evalu treatment proven imag featur could use biomark purpos studi investig featur mri clinic featur biomark associ surviv gbm | D001932;D005909 | T191 |
34,687,849 | differenti detect metastat inflammatori lymph node use inflow base vascular space occup ivaso mr imag investig potenti valu inflow base vascular space occup ivaso mr imag differenti metastat inflammatori lymph node lns | D008198;D008279 | T170;T023;T059;T060 |
34,687,848 | multipl two dimension activ shape model framework right ventricular segment segment right ventricl rv mri short axi imag challeng due complex shape various appear among differ subject cross section activ shape model asm shown potenti segment complex structur includ rv two formul two three dimension model report trade accuraci complex formul work propos new framework model rv surfac use multipl contour inform multipl cross section imag incorpor model propos method test use cardiac mri imag human subject compar golden refer manual delin rv contour propos method result signific lower error almost one half convent asm especi apic slice mean absolut distanc propos method mm convent asm result error mm addit comput time propos method compar min previous report asm formul | D006352;D021621 | T062;T023;T073;T060 |
34,687,847 | pancreat solid pseudopapillari neoplasm confus us analyz point view mri base radiom construct mri base radiom logist model differenti solid pseudopapillari neoplasm spn three differenti diseas contain adenocarcinoma neuroendocrin tumor net cystadenoma pancrea | D008279;D009369 | T191;T170;T059;T060 |
34,687,846 | casa variant design lower genom wide target effect stringent pam recognit casa rna guid endonucleas wide use conveni multiplex gene edit low target effect minim target gene edit engin variant lbcasa term lb kr stringent pam recognit lower target capabl similar edit effici vivo compar lbcasa also demonstr lbcasa lachnospiracea bacterium extens gene edit activ mammalian cell similar lb kr design lbcasa variant term lb kr stringent pam sequenc chang yyn tyn c n c g also display lower target effect therebi enabl potenti target site select low target common tttv v g c pam determin whether type mutat homolog posit similar effect casa kr evalu base result genom wide target test kr display lower target effect collect find indic cas protein could design stringent pam recognit reduc target effect suggest promis practic approach minim target effect genom edit | D064130;D064113 | T040;T116;T123 |
34,687,845 | singl dose replic poxvirus vector base rbd vaccin drive robust humor cell immun respons sar cov infect coronavirus diseas covid pandem requir continu develop safe long last efficaci vaccin prevent respons major outbreak around world especi isol develop countri combat sever acut respiratori syndrom coronavirus sar cov character temperatur stabl vaccin candid toh vac use replic compet attenu vaccinia virus vector express membran tether spike receptor bind domain rbd antigen evalu effect dose escal administr rout vaccin safeti efficaci immunogen anim model vaccin induc high level sar cov neutral antibodi favor cell respons maintain optim safeti profil mice cynomolgus macaqu demonstr robust immun respons protect immun sar cov variant singl dose togeth find support develop novel versatil vaccin platform altern complementari approach current vaccin | D000086382;D014612 | T116;T047;T121;T129;T067 |
34,687,844 | phylogenom biogeographi catalpa bignoniacea reveal incomplet lineag sort three dispers event catalpa scop bignoniacea small genus spp tree disjunct distribut among eastern asia eastern unit state west indi catalpa bear beauti infloresc cultiv import ornament tree landscap garden timber howev phylogenet relationship biogeograph histori genus remain unresolv studi use larg genom dataset includ data chloroplast plastom nuclear genom singl copi nuclear gene reconstruct phylogenet relationship within catalpa test interspecif gene flow event within genus infer biogeograph histori phylogenet result indic catalpa monophylet contain two main clade section catalpa section macrocatalpa section catalpa divid three subclad relationship congruent chloroplast nuclear dataset posit c ovata differ like due incomplet lineag sort interspecif gene flow event includ c bungei ss vector inherit c duclouxii c fargesii support combin three speci recogn broad circumscrib c bungei sl biogeograph studi suggest three main dispers event two occur oligocen first dispers event occur southwestern north america mexico greater antill give rise ancestor section macrocatalpa second dispers event also occur southwestern north america mexico led central northern north america subsequ reach china bere land bridg also reach europ north atlant land bridg third dispers event took place miocen china north america gave rise clade compos c bignonioid c speciosa studi use phylogenom approach biogeograph method infer evolutionari histori catalpa highlight issu associ gene tree discord suggest incomplet lineag sort like play import role evolutionari histori catalpa | D029402 | T002 |
34,687,843 | mesozo origin coleoid cephalopod abrupt shift diversif pattern coleoid divers group cephalopod mollusk origin date mesozo diversif pattern unknown howev two hypothes propos first suggest increas diversif rate cretac paleogen extinct event k pg consequ empti habitat left ammonit belemnit second hypothesi propos mid cenozo increas diversif rate relat distribut chang ice age biotic interact test hypothes estim lineag time ltt gamma statist along model base diversif rate analys conduct date molecular phylogeni coleoid reconstruct use five molecular marker cytochrom b rrna cytochrom oxidas rhodopsin pax diverg time estim suggest coleoid origin mesozo era middl triassic main clade decapodiform octopodiform diverg cretaceousjurass period ltt gamma statist diversif rate infer bayesian analysi macro evolutionari mixtur bamm indic acceler diversif rate time sinc origin coleoid addit bamm allow us detect abrupt increas diversif rate k pg boundari result partial support hypothes analys indic coleoid diversif rate increas cenozo howev result also indic increas diversif rate k pg boundari propos radiat coleoid shape acceler diversif rate time includ except episod abrupt increas k pg boundari | D049830 | T204 |
34,687,842 | homoploid hybrid allopolyploid high ploidi level character evolutionari histori western north american quillwort isot complex polyploidi hybrid import process seed free plant evolut howev major gap lie understand process affect evolutionari histori high ploidi system heterospor lycophyt genus isot lineag mani putat hybrid high level polyploid taxa rang tetraploid dodecaploid use complex western north american isot understand role hybrid high level polyploidi generat maintain novel divers uncov process use restrict site associ dna sequenc radseq multipl allel singl low copi nuclear marker whole plastom cytolog genom size estim chromosom count reproduct status fertil steril dataset show hybrid occur easili speci complex bidirect ident differ cytotyp furthermor show fertil allopolyploid appear form repeat steril homoploid interploid hybrid propos low prezygot reproduct barrier high frequenc whole genom duplic allow high level polyploid system generat novel lineag mechan may import shape extant isot divers | D011003;D011123 | T049;T025;T081 |
34,687,841 | controversi associ gut urinari microbiota kidney stone format nephrolithiasi kidney stone one common chronic kidney diseas typic common among adult men compar adult women preval diseas increas influenc genet environment factor kidney stone main compos calcium oxal urinari oxal consid danger factor format besid divers lead reason progress nephrolithiasi gut urinari microbiom recogn major player develop prevent microb produc metabolit divers effect host biolog function therefor chang composit structur microbiom dysbiosi implic various diseas present review focus role gut urinari kidney stone format | D000069196;D007669;D064307 | T007;T047;T001;T032;T028 |
34,687,840 | g protein alpha subunit cgga mediat growth sporul penetr pathogen colletotrichum gloeosporioid colletotrichum gloeosporioid main pathogen caus rubber anthracnos bring huge econom loss natur rubber industri heterotrimer g protein play vital role signal transduct filament fungi g alpha subunit major compon g protein studi character group g subunit cgga c gloeosporioid homolog magb pyricularia oryza cgga encod amino acid protein galpha domain delet cgga result reduc veget growth conidia yield mutant produc fruit bodi cgga delet mutant also exhibit decreas conidi germin appressorium format signific moreov mutant obvious defici penetr lose virul complet transcriptom analysi show cgga could affect express mani gene relat carbohydr metabol amino acid metabol signal transduct etc conclus cgga regul growth asexu sexual sporul appressorium format penetr pathogen c gloeosporioid | D020231;D044385 | T004;T116;T126 |
34,687,839 | protein core genom corynebacterium ulceran respond pathogen reveal promis vaccin target diphtheria corynebacterium ulceran emerg pathogen abl transmit acut infect diphtheria human although well establish vaccin base toxin produc corynebacterium diphtheria anoth speci genus known caus diseas still vaccin formul describ c ulceran fact contribut increas case infect observ studi want provid inform genom level bacterium order suggest protein possibl vaccin target carri silico prospect vaccin candid revers vaccinolog target exhibit antigen potenti diphtheria found import virul factor adhes relat one respons pathogen host interact infect find diphtheria toxin main compon current avail vaccin studi provid detail inform exoproteom hypothet protein core genom c ulceran suggest vaccin target test vitro develop new vaccin diphtheria | D003354;D004165;D014612 | T129;T047;T121;T116 |
34,687,838 | global preval norovirus case acut gastroenter updat systemat review meta analysi worldwid respons toward acut gastroenter epidem well known absenc updat systemat review global norovirus epidemiolog case gastroenter exist aim conduct updat systemat review meta analysi studi assess norovirus preval among gastroenter patient worldwid | D017250;D005759;D029322 | T047;T005 |
34,687,837 | ocular microbi divers communiti structur function high altitud investig composit function ocular surfac microbiom healthi peopl differ altitud | D000531;D064307 | T032;T001;T028;T081 |
34,687,836 | meta analysi cross section studi frequenc risk factor associ canin morbillivirus infect china canin morbillivirus previous known canin distemp virus cdv pathogen infect dog worldwid caus fatal diseas cdv broad rang host infect least six order mammalian famili domest dog main host cdv play central role transmiss virus howev preval cdv infect china remain unknown sinc studi systemat analys preval cdv domest dog countri therefor conduct systemat review meta analysi frequenc cdv posit associ risk factor cdv chines domest dog | D004216;D004217;D018185 | T047;T005 |
34,687,833 | anti hyperuricem effect green alga enteromorpha prolifera polysaccharid via regul uric acid transport vivo novel polysaccharid obtain enteromorpha prolifera epp purifi diethylaminoethyl cellulos sephadex g chromatographi fourier transform infrar spectroscopi high perform liquid chromatographi nuclear magnet reson nmr spectroscopi employ analys structur epp main compris rhamnos glucuron acid galactos arabinos xylos molar ratio averag molecular weight kda seven major glycosid residu identifi nmr follow l araf l rhap l rhap galp glcpa glcpa xylp effect epp hyperuricem mice determin analys correl general physic paramet renal histopatholog renal gene express gut microbiom epp signific reduc serum uric acid ua serum blood urea nitrogen serum xanthin oxidas xod hepat xod well improv histolog paramet hyperuricem mice furthermor mrna protein express analys show upregul ua excret gene abcg oat npt downregul ua resorpt gene urat moreov epp maintain stabil intestin flora confirm parasutterella close relat regul hyperuricemia studi first demonstr anti hyperuricem activ epp highlight therapeut potenti hyperuricemia relat diseas | D010936;D011134 | T121;T109;T123 |
34,687,829 | effect second generat antipsychot withdraw occurr vacuous chew movement anim model review abrupt discontinu antipsychot associ increas risk advers event extrapyramid symptom human anim model vacuous chew movement may occur antipsychot discontinu aim assess vacuous chew movement discontinu second generat antipsychot anim model | D013375 | T048;T184 |
34,687,828 | dopamin sensit methamphetamin treatment prior instrument train delay transit habit femal rat earli instrument learn behavior goal direct sensit chang valu instrument outcom suffici repetit respond becom insensit chang outcom valu habitu previous found femal transit habit distinct rang train reinforc respons low level instrument train mark less shown support habitu respond male rat begin investig earli develop habit femal conduct seri experi pretreat femal rat methamphetamin meth aim sensit central dopamin major modul striatal function prior instrument nose poke train begin endpoint transit rang femal follow train test sensit reinforc devalu rd conduct repeat pair reinforc previous earn train lithium chlorid licl induc ill counterpoint seri similar experi conduct separ male rat addit order ascertain valid use nose poke instrument respons compar sensit devalu pavlovian approach toward food magazin nose poke respons femal vehicl group respond habitu manner train level reinforc respons wherea meth group remain sensit devalu suggest increas central dopamin delay habit format femal rat male rat vehicl group demonstr goal direct respond follow train reinforc respons margin goal direct respond meth pretreat male sensit devalu train level howev follow extend train reinforc respons meth pretreat male respond habitu manner indic increas central dopamin advanc habit format male rat overal result suggest meth pretreat maintain goal direct respond femal rat typic transit habitu control instrument behavior advanc habit format male rat given suffici instrument train addit found differenti rd sensit nose poke respons use instrument train compar pavlovian approach toward food magazin confirm distinct two behavior nose poke valid instrument respons | D003216;D006184;D012054 | T033;T061;T041;T055 |
34,687,826 | uncontrol eat healthi women limit influenc food cue reactiv food relat inhibitori control uncontrol eat general popul character over hedon hunger drawn toward palat food theoret result strong food reward signal relat poor abil exert inhibitori control food consumpt influenc inhibitori control food cue sensit relat continu urg eat remain unclear use fmri order investig neural mechan under food cue reactiv food specif respons inhibit go nogo task compar women report high n versus lowaverag n uncontrol eat across two session inter meal state consumpt high calor snack found effect individu differ uncontrol eat food consumpt interact food cue reactiv differ uncontrol eat food consumpt interact modul activ occipit pariet network extend left later superior occipit cortex visual cortex cuneal cortex precuneus respons inhibit non food stimuli area previous associ success nogo vs go trial yet behaviour perform go nogo task modul uncontrol eat food consumpt women lowaverag tendenc uncontrol eat may need cognit resourc support success respons inhibit non food stimuli food go block inter meal state wherea women high tendenc uncontrol eat show food consumpt howev consid current previous find seem individu differ uncontrol eat healthi women limit influenc food cue reactiv food relat inhibitori control | D003463;D005502 | T168;T078 |
34,687,825 | appetit behavior bodi composit school age year bi direct analys popul base birth cohort cross section studi consist associ appetit behavior child bodi mass index howev prospect studi investig associ appetit measur bodi composit direct aim investig bi direct relationship appetit behavior bodi composit school age children data children generat xxi birth cohort analyz appetit behavior assess year children eat behavior questionnair higher fat mass fat free mass measur tetrapolar bioelectr imped waist weight waist height ratio calcul fat fat free mass index waist weight waist height age sex specif z score calcul cross lag analys perform bodi composit appetit behavior revers measur magnitud direct associ fat mass waist height ratio predict greater food approach behavior enjoy food food respons desir drink emot over waist weight seem consequ child avid appetit eg enjoy food standard ci p child score food avoid behavior satieti respons standard ci p slow eat standard ci p predict lower fat free mass appetit behavior may sole predict weight status path associ bodi composit later appetit behavior may also true especi food approach behavior adipos tissu intervent aim prevent excess weight focus appetit behavior moreov children higher adipos pathway also seem regul appetit need consid intervent | D000089822;D005247 | T040;T098;T055 |
34,687,824 | eater profil associ factor pediatr patient pedianut cohort appetit trait multifactori origin associ environment genet factor could becom problemat lead feed eat disord fed dsm classif suitabl pediatr fed anoth way describ eat behavior distinguish clinic profil small eater big eater aim studi identifi socio demograph medic factor associ profil compar problemat non problemat profil pedianut studi analyz socio demograph medic famili histori data among children accord age group year n year n year n year n inform collect eat behavior made possibl defin small eater profil sep big eater profil bep use predefin grid bep frequent adolesc sep frequent children age year bep associ separ parent male oldest sibl p problemat bep associ eat watch televis girl sensori disord p sep associ whatev age non breastfeed chronic ill psycholog histori sensori disord languag delay year age group famili histori fed adolesc group p analysi factor associ eater profil open new perspect research risk factor associ eat trait warrant studi larger popul delin transit healthi problemat eat | D005247;D001068 | T040;T048;T047;T055 |
34,687,823 | social media influenc adolesc food choic mix studi systemat literatur review adolesc least one social media account presenc social media continu grow food beverag brand capit trend market product social media adolesc depend nutrit valu product market social media advertis influenc may contribut risk develop unfavor health outcom obes hypertens type diabet review aim investig social media food beverag advertis role influenc adolesc food choic apprais publish literatur systemat literatur review conduct report social media role adolesc food choic articl search cinahl pubm scholar journal use search term social media use food advertis adolesc food choic elig articl select base inclus criteria prisma guidelin follow studi qualiti assess use mix method apprais tool analysi conduct use narrat analysi identifi key find record six articl met inclus criteria studi reveal two major find adolesc like recal unhealthi food celebr influenc common compon advertis review suggest food beverag compani use social media market product target adolesc popul use celebr influenc promot unhealthi product appear common use tactic find healthcar profession consid screen adolesc routin social media use current eat habit educ adolesc parent famili health risk addit implement legisl polici may benefici prevent exposur | D003924;D061108 | T047;T170 |
34,687,818 | format mechan amorph drug nanoparticl use antisolv precipit method elucid vari prepar temperatur present studi focus effect prepar temperatur physicochem properti amorph drug nanoparticl clarifi format mechan amorph glibenclamid glb nanoparticl prepar c use two antisolv precipit method method n n dimethylformamid dmf solut glb ad aqueous solut contain hydroxypropyl methylcellulos hpmc obtain nano suspens method b nano b suspens obtain ad dmf solut contain glb hpmc water prepar temperatur c nano nano b show similar hpmc composit howev nano b contain larg amount hpmc compar nano temperatur c glassi natur nanoparticl core restrict diffus hpmc amorph glb nanoparticl aqueous phase indic glass transit temperatur g neat amorph glb c would consider decreas owe nanos water sorption amorph glb physic stabil amorph glb nanoparticl improv increas hpmc nanoparticl thus set prepar temperatur consid g antisolv satur amorph drug nanoparticl essenti develop stabl amorph drug nanoparticl | D053758 | T073 |
34,687,817 | strategi osteoarthr therapi improv deliveri triptolid use liposom load dissolv microneedl array osteoarthr oa chronic diseas serious impair peopl physic function qualiti life triptolid tp promis anti inflammatori drug treatment oa limit clinic applic due sever system toxic poor solubl rapid elimin bodi extend applic prospect oa treatment develop liposom load dissolv microneedl dmn system effect deliv poor water solubl tp improv oa symptom incorpor tp dmns triptolid liposom tp lipo entrap effici prepar ethanol inject subsequ tp lipo concentr ultrafiltr tube mix hyaluron acid solut prepar dmns tp lipo load dmns tp lipo dmns show suffici mechan insert properti penetr rat skin drug distribut vivo show tp lipo dmns slow releas effect compar intra articular inject vivo pharmacodynam research show tp lipo dmns signific reduc knee joint swell level inflammatori cytokin tnf il il micro ct histolog evalu show tp lipo dmns effect reduc cartilag destruct allevi oa symptom result support tp lipo dmns may promis option oa treatment | D008081;D010003 | T047;T109 |
34,687,816 | innov vaccin platform infecti diseas scope covid pandem classic vaccin prove great efficaci elimin serious infecti diseas innov vaccin platform open new pathway overcom danger pandem via develop safe effect formul platform play key role either antigen deliveri system immun stimul induc innat adapt immun respons liposom lipid nanoparticl virus like particl nanoemuls polymer inorgan nanoparticl well viral vector belong nanoscal main categori innov vaccin current market clinic preclin phase paper review formul use vaccinolog discuss connect develop safe effect prophylact vaccin sar cov | D000086382;D003141;D014612 | T116;T047;T121;T129;T067 |
34,687,815 | reliabl releas test nanoparticl nanodi system innov sampl separ techniqu one critic qualiti attribut nanoparticl formul drug releas releas properti therefor well character predict discrimin method howev present still standard method releas test extend releas nanoformul dialysi techniqu wide use literatur suffer sever drawback burst releas formul mask slow permeat kinet free drug dialysi membran satur membran absenc agit membran studi releas profil poli lactic co glycol plga nanocapsul load tran retino acid character use innov sampl separ set nanodi system compar releas profil measur dialysi techniqu nanodi system show clear superior dialysi method abl accur character burst releas capsul furthermor discrimin differ tran retino acid nanoparticl formul | D053758;D011100 | T122;T073;T109 |
34,687,814 | biofilm inhibit activ donor nanosilica enhanc antibiot action nitric oxid emerg promis antibacteri agent donor compound explor investig role silica nanoparticl contain nitroprussid mpsi np donor agent methicillin sensit atcc atcc methicillin resist atcc atcc staphylococcus strain biofilm inhibit studi along antibiot activ combin standard antibiot ampicillin tetracyclin mpsi np exhibit thermal releas within h free nitroprussid releas dialysi assay indic assist releas mediat nanoparticl nanomateri show moder activ block biofilm product exhibit signific decreas number viabl bacteri cell fold staphylococcus aureus atcc staphylococcus epidermidi atcc remark even use mpsi np concentr antibacteri action combin ampicillin promot signific decreas mic resist strain aureus atcc fold epidermidi atcc fold carbopol base gel formul mpsi np ww prepar show zone inhibit mm epidermidi atcc topic use mpsi np combin antibiot might manag strategi prevent eventu treat complic resist bacteri infect | D055624;D013203 | T007;T047 |
34,687,813 | role physicochem properti grade hydroxypropyl methylcellulos vitro mucoadhes relationship physicochem properti hydroxypropyl methylcellulos hpmc compact vitro mucoadhes perform investig studi commerci grade hpmc k e e e km em km prepar compact surfac hydrophil hydrat behavior character vitro mucoadhes perform determin tensil strength compact differ region mucos membran buccal sublingu stomach intestin posit correl found viscos hpmc compact contact angl differ simul bodi fluid viscos hpmc compact vitro mucoadhes forc contact angl vitro mucoadhes forc hydrat increas increas viscos hpmc compact polar lipid content mucosa found import factor affect mucoadhes lower polar lipid amount mucos membran promot rate mucoadhes forc increas viscos hpmc mucoadhes mechan various grade hpmc compact studi use thermodynam analysi lifschitz van der waal lw interact lewi acid base ab interact total free energi adhes g tot provid predict overal tendenc mucoadhes deviat measur mucoadhes forc | D008747 | T130;T121;T109 |
34,687,812 | tdp essenti eph receptor class specif spinal motor axon trajectori limb neural circuit format neuron growth cone must guid precis neuron muscl target achiev activ membran bound guidanc receptor peripheri howev mechan regul tempor avail receptor remain larg unknown tar dna bind protein tdp propos bind mrnas guidanc receptor thus prompt us investig role axon guidanc spinal later motor column lmc neuron limb mesenchym first identifi tdp express lmc neuron stage axon growth limb use situ mrna hybrid loss gain tdp function chick lmc neuron redirect axon trajectori opposit effect mice spinal motor neuron specif tdp delet led misrout lmc axon ectop tdp express increas ephb protein level lmc neuron suggest tdp mediat lmc pathfind regul ephb express final tdp level influenc growth prefer lmc neurit ephrin b netrin semaphorin ligand result demonstr tdp essenti ephrinb ephb signal mediat axon trajectori select lmc subtyp limb | D001369;D004268;D036081 | T116;T123;T026;T192;T126 |
34,687,811 | electrophysiolog index impair respons inhibit salienc attribut substanc stimul depress use disord meta analysi impair inhibitori control reward system core featur under substanc use disord sud previous studi suggest regard impair respons inhibit salienc attribut syndrom irisa neural substrat two deficit function wide investig neuroimag studi impair prefront cortex limbic orbitofront network fronto insular pariet network observ previous event relat potenti erp studi also conduct explor eeg index relat abnorm brain function current meta analysi aim explor consist erp index reflect two aberr process pslow potenti sp salienc attribut error relat negat ern nogo nnogo p inhibitori control conflict monitor subgroup analys drug type drug use condit also conduct accord research studi found signific enhanc drug cue induc p amplitud attenu nogo n amplitud sud individu relat healthi control hc support dual model moreov drug cue induc p display time depend recoveri suggest potenti index treatment evalu conclus drug cue induc p nogo n demonstr high consist drug cue induc p use track chang function recoveri sud integr two erp compon could regard potenti biomark sud may provid new insight clinic treatment investig | D005071;D019966 | T033;T048;T042 |
34,687,810 | randomis methodolog develop studi investig plaqu remov efficaci manual toothbrush studi aim evalu plaqu remov efficaci toothbrush guid clinic model develop | D014099 | T061 |
34,687,809 | glucos metabol pseudomona aeruginosa cyclic produc polyhydroxyalkano rhamnolipid pseudomona aeruginosa import chassi product polyhydroxyalkano pha rhamnolipid rhl advanc understand biosynthesi metabol biocompound crucial increas yield c metabol flux ratio analysi c mfa techniqu estim vivo metabol flux ratio pha rhl essenti non growth associ product biotechnolog interest contain hydroxyalkano whose label pattern could access gc ms studi reveal relat contribut entner doudoroff ed pathway non oxid pentos phosphat pp pathway pha rhl product c mfa perform pseudomona aeruginosa lfm suppli label glucos bacteri strain lack function emp oxid pp branch label pattern measur experi u c glucos indic low flux though pp pathway optim design label experi show c glucos would best substrat enabl estim ed flux high accuraci result experi perform isotop indic two third glyceraldehyd phosphat recycl cyclic ed architectur suggest p aeruginosa util cycl regul nadphacetyl coa ratio pha rhl biosynthesi | D054813 | T109 |
34,687,808 | function px receptor hematopoiesi leukemogenesi adenosin triphosph atp accumul tissu injuri inflamm site px receptor atp gate ion channel known cytotox activ howev px receptor also play import role growth cancer immun regul function px receptor wide express murin human hematopoiet stem cell lineag includ monocyt macrophag mast cell b lymphocyt particip various physiolog patholog activ therefor surpris px receptor import normal hematopoiesi leukemogenesi summar biolog function px receptor normal hematopoiesi leukemogenesi particular found atp level dramat increas leukem bone marrow nich fate leukemia initi cell acut myeloid leukemia tight control px express atp px mediat signal pathway find strong indic px receptor may consid potenti biomark hematolog malign bone marrow nich antagonist may use leukemia treatment addit tradit chemotherapi | D006410 | T042 |
34,687,807 | hematopoiet stem progenitor cell outsid bone marrow bone marrow bm primari site adult blood product host major hematopoiet stem progenitor cell hspcs rare hspcs also found outsid bm steadi state time larg hematopoiet demand bm failur substanti product matur blood cell hspcs occur number tissu process term extramedullari hematopoiesi emh past decad understand bm hematopoiesi advanc drastic contrast littl focus studi extramedullari hspc pool contribut blood product summar current known extramedullari hspcs emh mice human describ evid exist extramedullari hspc pool steadi state discuss role hematopoiet stress respons highlight although emh human much less pronounc like physiolog distinct mice inform premalign malign chang final reflect open question field whether better understand emh particular human may relev clinic implic hematolog nonhematolog disord | D006411 | T042 |
34,687,805 | screen paroxysm atrial fibril primari care use holter monitor intermitt ambulatori singl lead electrocardiographi time detect atrial fibril af import increas risk thrombo embol event singl time point screen intervent fall short detect paroxysm af requir prolong electrocardiograph monitor usual use holter howev tradit h holter monitor less appropri screen purpos low diagnost yield intermitt ambulatori screen use singl lead electrocardiogram l ecg devic offer effici altern | D001281 | T047;T046 |
34,687,802 | ldl cholesterol target achiev heterozyg famili hypercholesterolemia patient accord escea lipid guidelin implic newer lipid lower treatment european guidelin escea treatment dyslipidaemia recommend aggress target low densiti lipoprotein cholesterol ldl c patient famili hypercholesterolemia fh current lipid lower treatment often inadequ achiev target | D000924;D019161;D006938 | T047;T121;T109 |
34,687,800 | subclin left ventricl impair follow breast cancer radiotherapi associ segment dose segment strain dysfunct cardiotox follow breast cancer radiotherapi rt repres one redoubt toxic global longitudin strain measur gls base speckl track imag sti allow detect left ventricular lv dysfunct subclin stage aim prospect studi detect patient risk cardiotox use echocardiograph paramet determin associ segment rt dose earli cardiac toxic | D001943;D018487 | T191;T046 |
34,687,799 | effect intraspecif chemic cue behaviour bloodfin tetra aphyocharax anisitsi ostariophysi characida chemic communic induc multitud behaviour detect fish olfactori system parent care predat alarm signal forag school reproduct migrat chemic cue provid inform visual trait fish respond chemic cue without addit sensori cue way pheromon play essenti role fit fish given aphyocharax anisitsi inhabit environ character cloudi high veget water interest evalu olfactori contribut communic investig relev chemic cue type behaviour trigger anisitsi two experiment context non social olfactori context conspecif chemic cue social context conspecif femal male presenc non social context experi suggest male anisitsi respond male femal chemic cue even absenc sensori input high olfactori sensit characid general anisitsi particular could facilit vital function forag conspecif recognit habitat impos sever restrict visual system | D060126 | T013 |
34,687,798 | serratia marcescen outbreak covid intens care unit factor specif covid unit facilit bacteri cross contamin covid patient covid dedic unit creat earli pandem despit need factor specif unit possibl increas risk bacteri cross contamin covid patient report serratia marcescen outbreak covid intens care unit later discuss factor specif covid unit may facilit bacteri cross contamin unit rais awar issu | D000086382;D003428;D016868 | T047;T067 |
34,687,797 | predict dmri signal neural architectur search grow interest neurosci communiti estim map microscop properti brain tissu non invas use magnet reson measur machin learn method activ investig predict signal measur diffus magnet reson imag dmri | D038524;D016571 | T170;T060 |
34,687,796 | transcript factor sp regul ski mediat astrocyt prolifer vitro transcript factor bind specif sequenc upstream end target gene ensur proper spatiotempor express target gene studi aim demonstr transcript factor sp regul express ski gene specif bind site sp thus enabl ski regul astrocyt prolifer upstream regul mechan astrocyt prolifer explor regul format glial scar specif time space spinal cord injuri jaspar ucsc databas use predict transcript factor bind threshold gradual reduc screen transcript factor upstream ski lead identif sp next analyz correl express sp ski normal astrocyt reactiv astrocyt well chang astrocyt prolifer confirm sp regul ski astrocyt prolifer astrocyt transfect sirna target sp astrocyt prolifer analyz final dual luciferas report assay chromatin immunoprecipit chip assay confirm promot region ski contain specif sp bind site first sp identifi confirm play import role astrocyt prolifer regul ski express result may help identifi novel target treatment spinal cord injuri | D001253;D013119 | T025;T037 |
34,687,795 | alter visuospati process schizophrenia event relat potenti microst analysi compar patient without hallucin healthi control patient schizophrenia present various symptom relat differ domain abnorm auditori visual percept part general problem nevertheless relationship lifetim histori auditori verbal hallucin avh one preval symptom schizophrenia visuospati deficit remain unclear studi aim investig differ hemispher involv visuospati process healthi control hcs schizophrenia patient without avh hcs n schizophrenia patient avh avh group n schizophrenia patient without hallucin nh group n particip choic reaction task later stimuli event relat potenti erp microst approach use analyz erp differ condit group schizophrenia patient without hallucin slower respons hcs earli visual n contralater stimul side promin group particip decreas amplitud patient schizophrenia especi avh group right hemispher amplitud pb cognit evalu compon also decreas schizophrenia compar avh hc group patient nh group alter microst pattern pb replac novelti compon pa although differ patient group base presenc avh find indic patient specif visuospati deficit associ lifetim histori hallucin patient avh show earli visual compon alter right hemispher without avh promin visuospati impair | D012559 | T048 |
34,687,794 | metabol brain network surgic outcom tempor lobe epilepsi graph theoret studi base f fluorodeoxyglucos pet drug resist tempor lobe epilepsi tle potenti candid surgeri howev near one third subject poor surgic prognosi studi under neuromechan relat surgic prognosi use graph theori base metabol brain network sixti four unilater tle subject preoper f fluorodeoxyglucos fdg pet scan retrospect enrol divid ia engel class ia n non ia engel class ib iv n group accord year follow unilater anterior tempor lobectomi atl metabol brain network construct chang metabol connect ia non ia detect compar match healthi control hcs network properti includ small world global effici calcul hub node also identifi group respect non ia group exhibit increas connect contralater fusiform gyrus contralater lingual gyrus ia show decreas connect main among bilater frontal tempor pariet cortex graph theoret analysi reveal non ia group show increas small world p compar hcs elev global effici p decreas l p p compar ia group ia group show reduc c p p increas small world p compar hcs furthermor disrupt hub node distribut pattern midcingul gyrus disappear also found non ia group compar ia group result reveal elev network integr metabol connect redistribut hub node pattern associ ongo postop seizur subject intract tle | D004833;D019788 | T130;T047;T109 |
34,687,789 | candid sex associ gene identif trachinotus ovatus carangida use integr slaf seq bulk segreg analysi approach difficult distinguish sex trachinotus ovatus base appear littl data sex determin gene avail speci generat f individu use parent r r dna sampl collect individu sex aggreg sex specif dna pool specif locus amplifi fragment sequenc integr bulk segreg analysi detect candid sex associ gene approxim high qualiti singl nucleotid polymorph snp marker high qualiti insert delet indel marker generat six candid region within chromosom encompass candid gene identifi close relat sex base annot six gene evm evm evm evm evm evm predict close associ sex result present effici genet map approach lay foundat molecular sex discrimin ovatus | D020641 | T086 |
34,687,785 | sar cov microfluid antigen point care test emerg room patient covid pandem emerg room point care antigen test sar cov antigen expedit clinic strategi patient manag test consecut patient italian second wave peak use recent lumiradx microfluid assay assay show high concord sensit specif compar molecular test high valuabl | D000086382;D000086402 | T047;T005;T067 |
34,687,784 | optim magnet bead base nucleic acid extract sar cov test use readili avail reagent covid pandem highlight need generic reagent flexibl system diagnost test magnet bead base nucleic acid extract protocol use well plate open liquid handler readili amen meet need one approach rigor optim minim cross well contamin maintain sensit | D000086382;D009696 | T123;T047;T114;T067 |
34,687,783 | unresolv inflamm hospit associ post discharg institution mortal geriatr rehabilit inpati resort cohort inflamm contribut advers health outcom communiti dwell popul littl known inflamm hospit older adult associ advers outcom studi aim evalu associ inflammatori marker c reactiv protein crp albumin measur acut geriatr rehabilit hospit institution mortal geriatr rehabilit inpati | D007297;D010351 | T058;T101 |
34,687,782 | risk factor covid subject without mental disord subject mental disord higher risk various pandem specif studi concern screen compar risk factor covid subject without mental disord role differ class mental disord respect covid | D000086382;D001523 | T048;T047;T067 |
34,687,781 | cross section studi psycholog status hospit worker late stage covid outbreak hospit worker intens psycholog pressur sinc covid outbreak analyz psycholog status hospit staff late period covid provid basi construct global health care covid outbreak | D000086382 | T047;T067 |
34,687,780 | prefront transcrani magnet stimul depress us militari veteran naturalist cohort studi veteran health administr repetit transcrani magnet stimul tms evid base treatment pharmacoresist major depress disord mdd howev evid veteran mix end va implement nationwid tms program includ evalu clinic outcom within naturalist design tms hypothes safe provid clinic meaning reduct mdd posttraumat stress disord ptsd symptom | D003865;D013313;D014728 | T048;T098 |
34,687,779 | exogen hesperidin chlorogen acid allevi oxid damag induc arsenic toxic zea may regul water status antioxid capac redox balanc fatti acid composit arsenic toxic problem need solv term human health agricultur product vast major world presenc caus biomass loss disrupt balanc biochem process plant prevent growthwat absorpt root accumul edibl part plant enter food chain critic method combat toxic use biosaf natur bioactiv compound hesperidin hp chlorogen acid ca end studi physiolog biochem effect hp ca investig zea may arsenat stress relat water content osmot potenti photosynthesi relat paramet suppress stress determin stress decreas activ antioxid system increas level satur fatti acid gene express pht transport involv uptak transloc arsenat expos stress hp ca improv capac superoxid dismutas sod catalas cat peroxidas pox glutathion transferas gst glutathion peroxidas gpx ros accumul h lipid peroxid tbar effect remov phenol compound contribut maintain cellular redox status regul enzymenon enzym activitycont involv asa gsh cycl hp ca revers advers effect excess metal ion accumul regul express pht pht gene respons stress exogen appli hp ca effect maintain membran integr regul saturatedunsatur fatti acid content howev combin applic hp ca show synergist protect activ stress negat effect antioxid capac maiz leav result hp ca great potenti provid toler maiz stress reduc oxid injuri preserv biochem reaction photosynthesi | D001151;D006569 | T121;T109;T131;T127;T196 |
34,687,778 | polychlorin dibenzo p dioxin dibenzofuran lotus lake histor pollut chlor alkali industri occurr organ distribut health risk dietari intak studi organ distribut exposur risk dietari intak polychlorin dibenzo p dioxin dibenzofuran pcddfs investig lotus collect ya er lake lake hubei provinc central china histor pollut chlor alkali industri highest concentr pcddfs found main fibrous lotus root mean valu pgg pgg respect investig sampl octa cdd ocdd octa cdf ocdf predomin congen pcddfs respect follow hpcdf distribut ratio pcddfs adjac lotus organ indic pcddfs accumul easili edibl organ lotus seed membran leav teq edibl lotus organ probabl daili intak pdi lotus product resid calcul toxic equival lotus fruit part reach mean pg teq g dw mean week intak lotus product adolesc live around ya er lake pg teqkg bwweek result suggest long term consumpt lotus product ya er lake present health hazard resid | D001572;D004147;D011078;D000072317 | T131;T121;T109 |
34,687,777 | landscap composit drive impact artifici light night insectivor bat among preval sourc biodivers declin artifici light night alan emerg threat global biodivers much knowledg alreadi gain reduc impact howev spatial variat alan effect biodivers interact landscap composit remain littl studi though utmost import identifi lightscap need action sever studi shown local scale tree cover intensifi posit negat effect alan biodivers none landscap scale studi wider rang landscap composit around lit site hypothes magnitud alan effect depend landscap composit speci toler light take case insectivor bat vari sensit alan investig speci specif activ respons alan bat activ record along gradient light radianc ensur larg variabl landscap composit around sampl site among bat taxa studi radianc decreas activ two group slow fli gleaner guild myoti plecotus spp one speci aerial hawk guild pipistrellus pipistrellus increas activ two speci aerial hawk guild pipistrellus kuhlii pipistrellus pygmaeus among five effect magnitud four driven landscap composit five speci alan effect detect particular landscap composit make main effect radianc undetect without account interact landscap specif effect strongest non urban habitat guild result highlight import priorit alan reduct effort non urban habitat import account landscap composit studi alan effect bat avoid miss effect | D002685 | T015 |
34,687,776 | igf driven induct gpcr kinas primari affer neuron promot resolut acut hyperalgesia dynam regul g protein coupl receptor gpcr kinas grk express restor cellular function protect overstimul via gpcr non gpcr signal primari affer neuron grk negat regul nocicept tone present studi test hypothesi induct grk primari affer neuron contribut resolut acut pain tissu injuri grk express dorsal root ganglion drg analyz day incis intraperiton administr grk inhibitor perform day post incis male spragu dawley rat underw plantar incis analyz pain relat behavior effect grk inhibitor separ grk express analyz inject insulin like growth factor igf rat hind paw addit igf receptor igfr inhibitor administ plantar incis rat determin effect incis induc hyperalgesia grk express plantar incis induc increas grk drg day day post incis acut hyperalgesia plantar incis disappear day post incis intraperiton inject grk inhibitor time reinstat mechan hyperalgesia although grk inhibitor produc hyperalgesia naiv rat incis igf express increas paw drg intraplantar inject igf increas grk express ipsilater drg igfr inhibitor administr prevent induct grk resolut hyperalgesia plantar incis find demonstr induct grk express driven tissu igf potent analges effect produc resolut hyperalgesia tissu injuri dysregul igf grk signal could potenti lead failur spontan resolut acut pain henc develop chronic pain surgeri | D054769;D006930;D007334;D009475 | T116;T184;T123;T025;T126 |
34,687,770 | extracellular vesicl cardiovascular diseas biolog function therapeut implic extracellular vesicl ev includ exosom microvesicl lipid bilay particl natur releas cell exosom form intralumin vesicl ilv multivesicular endosom mves releas extracellular space upon mve plasma membran fusion microvesicl generat direct outward bud plasma membran exosom microvesicl membran orient differ yet overlap size cargo content select pack depend sourc cell type function state exosom microvesicl transfer bioactiv rnas protein lipid metabolit donor recipi cell influenc biolog properti latter last decad potenti role effect inter tissu communic cardiovascular physiolog patholog increas appreci addit ev attract sourc biomark diagnosi prognosi diseas acquir complex cargo cellular process intim link diseas pathogenesi furthermor ev obtain various stemprogenitor cell popul test cell free therapi various preclin model cardiovascular diseas demonstr unequivoc encourag benefit summar find recent research biolog function ev ischem heart diseas heart failur potenti novel diagnost biomark therapeut opportun | D002318;D055252;D055354;D000067128 | T026;T047 |
34,687,769 | therapeut antibodi natur patholog barrier strategi overcom antibodi base therapeut becom major class therapeut recombin antibodi approv review eu us therapeut class experienc remark expans expect acceler due extraordinari global respons sar cov pandem public disclosur hundr anti sar cov antibodi main deliv intraven altern deliveri rout emerg improv antibodi therapeut index patient comfort major hurdl antibodi deliveri efficaci well develop altern administr rout understand differ natur patholog barrier antibodi face soon enter bodi moment bind target antigen review discuss well known investig extracellular cellular barrier face antibodi also discuss strategi develop recent year overcom barrier increas antibodi deliveri site action better understand biolog barrier antibodi face allow optim antibodi deliveri near target open way develop improv therapi less system side effect increas patient adher treatment | D000086382;D000086402 | T047;T005;T067 |
34,687,766 | tgf stimul nfatc atf protein interact matrix metalloproteinas express human breast cancer cell activ transcript factor atf induc stress gene stimul transform growth factor beta tgf protract relentless manner human mammari cancer cell hbc cell mda mb molecular mechan behind stabl express atf via tgf mda mb cell unknown studi found tgf stimul express nuclear factor activ cell nfatc mda mb cell provid evid interact atf function character nfatc associ atf determin silenc nfatc use sirna knock nfatc decreas express atf target gene mmp matrix metalloproteinas critic invas gene hbc cell chromatin immunoprecipit reveal tgf promot nfatc bind nfatc atf complex bind mmp promot region wherea silenc nfatc decreas bind hbc cell thus uncov mechan interact nfatc atf regul tgf nfatc act pivot factor provid atf stabil drove mmp transcript target nfatc block associ atf could therefor help slow progress breast cancer | D015972 | T045 |
34,687,765 | genom wide character express analysi cystathionin synthas gene plant develop abiot stress cotton gossypium spp cystathionin synthas cbs domain contain protein cdcps form larg famili play role develop via regul thioredoxin system well abiot biotic stress respons plant howev comprehens studi cbs gene remain elus cotton identifi cbs gene plant speci phylogenet analysi categor cbs gene four group whole genom segment dispers duplic event contribut ghcbs gene famili expans moreov orthologousparalog gene among three cotton speci g hirsutum g arboreum g raimondii detect synten map among eight plant speci strong purifi select dicotyledon monocotyledon cbs gene cis element relat plant growth develop abiot hormon respons observ transcriptom data qrt pcr valid ghcbs gene indic critic role ovul develop gene show high enrich ghcbs ghcbs ghcbs ghcbs ghcbs ghcbs ghcbs ghcbs gene regul various abiot hormon treatment differ time point involv ovul fiber develop provid key gene futur cotton breed program addit transgen tobacco plant overexpress ghcbs transient exhibit higher water chlorophyl content indic improv toler toward drought stress overal studi provid character ghcbs gene plant growth abiot hormon stress therebi intim signific cotton molecular breed resist cultivar | D003541;D018506;D018745;D003368 | T116;T002;T045;T028;T126 |
34,687,764 | align silk fibroinpoli hydroxybutyr nanofibr scaffold seed adipos deriv stem cell tendon tissu engin work investig tenogen differenti adipos deriv mesenchym stem cell admsc seed onto silk fibroinpoli hydroxybutyr sfphb scaffold align topographi high mechan strength electrospin process optim use respons surfac method rsm sfphb nanofibr matric total polym concentr sf phb flow rate mlh collector rotat speed rpm appli voltag kv collector distanc cm obtain averag fiber diamet nm nanofib align within rang sf reinforc reduc crystallin phb elast modulus found mpa scaffold show bacteriostat effect day cell cultur studi perform rat radmsc absenc presenc tenogen differenti factor gdf result demonstr sfphb scaffold allow cell prolifer differenti tenocyt howev signific effect gdf differenti cell observ find indic align sfphb scaffold signific potenti use tendon tissu engin | D005349;D006885;D011091 | T116;T122;T109;T123 |
34,687,763 | character potenti cellulos fiber cattail fiber studi micronano structur properti explor applic prospect cattail fiber cfs natur composit field import sustain develop new green light weight function biomass materi studi physic chemic properti micronano structur mechan characterist cfs investig cfs low densiti kg result transmiss electron microscopi tensil test data indic cattail trunk fiber ctf bundl compos parenchyma cell solid stone cell demonstr high specif modulus mpam kg high elong break turn cattail branch fiber cbf bundl compos parenchyma cell specif half honeycomb shape inner diaphragm divid cell open caviti structur featur endow ctf bundl stabl structur good oil absorpt storag capac chemic compon fourier transform infrar spectroscopi analys show cfs higher lignin content wax content conduc improv corros resist thermal stabil lipophil hydrophob properti cf final thermogravimetr analysi indic final degrad temperatur c benefici increas process cfs reinforc composit | D002482;D049329;D032401 | T002;T073;T109;T123;T122 |
34,687,762 | fluoxetin sertralin base multitarget inhibitor cholinesteras monoamin oxidas ab treatment alzheim diseas synthesi pharmacolog molecular model studi potenti therapi alzheim diseas ad cholinesteras che monoamin oxidas mao key enzym regul level acetylcholinesteras ach butyrylcholinesteras bche monoamin aim current research synthesi multi target compound concomit inhibit ches mao seri fluoxetin sertralin hybrid design evalu multi target inhibitor ches hmao vitro enzym inhibit studi demonstr number compound display excel inhibit submicromolar nanomolar rang howev compound possess excel concomit inhibitori activ ches hmao ab enzym thus emerg optim multi target hybrid vivo acut toxic studi show safeti synthes compound mgkg dose examin brain tissu swiss albino mice suggest select activ mao b inhibitor propens block mao b activ could respons neurodegen effect mice vitro inhibitori manner interact multipot compound four target confirm molecular dock investig | D002800;D005473;D008996;D020280 | T121;T109 |
34,687,761 | new find gfp like protein applic fluoresc tag fibrillogenesi oligomer amorph aggreg green fluoresc protein gfp common use fluoresc tag biosensor cell biolog medicin howev propens gfp like protein aggreg consequ intermolecular interact applic thorough examin work altern aggreg pathway superfold green fluoresc protein sfgfp demonstr use spectroscop microscop studi sampl prepar equilibrium microdialysi besid oligomer nativ monom show first time condit specif format sfgfp either amyloid fibril increas temperatur acid amorph aggreg physiolog condit type sfgfp aggreg lost green fluoresc toxic cell thus use gfp like protein fluoresc tag one take account high abil form aggreg lost uniqu visibl fluoresc cellular environ affect cell viabil moreov result work cast doubt correct data fibrillogenesi various amyloidogen protein obtain use fusion gfp like protein | D017930;D066329;D055503 | T116;T028;T067 |
34,687,760 | lipas immobil novel class zr mofelectrospun nanofibr polym biochem character effici biodiesel product studi due favor properti mof compound fibrous materi new nanostructur zr mofpvp nanofibr composit synthes electrospin procedur relat featur sampl character relev analyz includ sem bet surfac area analysi xrd ftir spectroscopi final product show signific properti small particl size distribut larg surfac area high crystallin strategi produc nanostructur could lead new compound novel altern materi biolog applic lipas mg success immobil mention nanofibr composit biochem character lipas activ free immobil lipas consid measur absorb pnpp mm trishcl buffer ph triton x c min differ concentr glutaraldehyd differ crosslink time differ time immobil differ enzym load differ ph valu optim result show optim immobil condit achiev glutaraldehyd h crosslink time h immobil time use mg prote support ph immobil enzym also total stabl min incub c free enzym show maximum activ ph optim ph immobil lipas shift ph unit alkalin area immobil lipas show fold higher stabil free enzym c dival metal ion includ cu co mg hg mn enhanc enzym activ immobil enzym maximum biodiesel product r communi oil obtain h incub lipas mg immobil lipas display high potenc biodiesel product h incub result indic high potenc zr mofpvp nanofibr composit effici lipas immobil | D004800 | T130;T116;T126 |
34,687,759 | vanillin chitosan miscibl hydrogel blend prospect print biomed applic present studi chitosan cs react vanillin schiff base reaction form vanillin cs vac deriv ftir h nmr spectra confirm derivat cs enhanc swell behavior long establish xrd measur state semicrystallin natur vac deriv step blend cs vac prepar ratio csvac ww format hydrogen bond notic ftir xrd measur structur optim perform within framework densiti function theori interact energi e int calcul collect result along viscos measur sem imag prove miscibl csvac blend optimum csvac ratio ink print applic prepar differ concentr wv wv wv wv augment sampl viscos valu influenc polymer concentr assess thereaft print applic conduct | D001709;D066330 | T091;T073 |
34,687,758 | hydroxyl singl wall carbon nanotub inhibit fibril disrupt pre form proto fibril patholog aggreg amyloid polypeptid associ numer degen diseas prevent aggreg clear amyloid deposit consid promis strategi amyloidosi capac cross blood brain barrier good biocompat hydroxyl singl wall carbon nanotub swcnt oh shown excel anti amyloid properti systemat studi swcnt oh effect fibril peptid util atom discret molecular dynam dmd simul result demonstr isol peptid first nucleat unstructur oligom follow coil sheet conform convers oligom least six peptid elong later surfac preform sheet could catalyz unstructur monom small oligom convert sheet format via dock lock fibril growth secondari nucleat process eventu peptid would self assembl well order cross structur regardless isol monom well defin cross assembl would attach surfac swcnt oh adopt unstructur format indic swcnt oh inhibit fibril also destroy pre form proto fibril overal studi display complet pictur fibril mechan amyloid inhibitori mechan swcnt oh offer new insight de novo design anti amyloid inhibitor | D016229;D010446 | T116 |
34,687,756 | pan cancer analysi experi cell line reveal slight elev express dlgap involv clear cell renal cell carcinoma progress disc larg associ protein dlgap kinetochor fiber bind protein function oncoprotein mani cancer howev express pattern pan cancer includ clear cell renal cell carcinoma ccrcc analyz herein aim evalu express common cancer especi ccrcc | D018450;D015972 | T033;T046;T045 |
34,687,754 | microplast pollut mountain terrain foothil review sourc extract distribut microplast remot area microplast mp pollut critic environment concern exist within differ mountain ecosystem compart review paper highlight sourc sampl distribut behavior mps mountain terrain foothil atmospher transport tourism major sourc mp pollut mountain ecosystem snow sampl provid maximum concentr mps compar stream ice core sampl precipit event consider influenc mp deposit fallout mountain glacier pe pp ps polyest pvc common plastic polym divers shape fiber fragment film pellet ecolog concern stress due mp accumul natur ecosystem also discuss consider focus mp transport distribut dynam higher altitud prospect futur research remark knowledg gap observ regard mp pathway mountain ecosystem assess microplast associ addit heavi metal toxic chemic includ evid nano size plastic furthermor studi ecolog biolog risk pose mps remot mountain sever limit respect global climat chang biodivers loss influenc ecosystem servic | D000080545;D014874 | T131;T122 |
34,687,753 | detect trizol contamin wast water use biocatalyst effect biodegrad potenti flubendiamid flubendiamid new class chemic pesticid broad spectrum activ lepidopteran pest due limit approach high specif toward various non target organ unrestrict applic pesticid promin altern organochlorin organophosph pesticid caus serious environment pollut studi wastewat use determin microbi strain pesticid degrad fungi microbi popul flubendiamid resist fungal strain character use enrich medium aerob bacteria log cfuml nitrifi bacteria cfuml lactobaillus log cfuml actinomycet log cfuml fungi log cfuml detect promin fungi genera fusarium trichoderma cladophialophora paecilomyc talaromyc penicillium aspergillus candida phyllosticta mycosphaerella ochroconi mucor minimum inhibitori concentr rapid grow organ fr reveal abil toler mgl flubendiamid concentr morpholog biochem molecular analysi reveal strain aspergillus terreus fr residu pesticid detect use high perform liquid chromatographi hplc high perform liquid chromatographi analysi reveal pesticid remov effici observ strain fr optim cultur condit h ph c mgl pesticid concentr strain fr degrad pollut wastewat improv water qualiti terreu sfr indigen fungus abil degrad trizol pesticid wastewat signific | D010575;D062065 | T131;T069;T083 |
34,687,752 | exposur particul matter direct indirect role covid pandem know transmiss factor natur environ favor spread viral infect crucial stop outbreak develop effect prevent strategi work aim evalu role particul matter pm covid pandem focus especi pm vector sar cov exposur pm relat new case clinic sever peopl infect sar cov explain oxid stress inflammatori respons generat particl enter respiratori system well role pm express ace respiratori cell human host addit differ author detect sar cov rna pm sampl outdoor indoor environ result various studi lead hypothesi aerosol emit infect person could deposit suspend particl sometim natur especi anthropogen origin form basal pm howev viabil virus pm yet demonstr pm confirm vector transmiss prevent strategi ought adapt pm sampl outdoor environ could becom indic viral load specif area | D000086382;D052638 | T167;T131;T047;T067 |
34,687,751 | arsenic trace metal concentr differ veget type assess health risk consumpt level trace metal loid tms veget type includ leafi veget purslan purpl basil parsley fruit veget pepper tomato eggplant cucumb zucchini green bean melon maiz grown malatya provinc turkey investig non carcinogen health risk consumpt crop assess level tms measur induct coupl plasma optic emiss spectrometri mean level ni cu cd cr zn crop maximum permiss concentr mpcs pb pepper mgkg fw eggplant mgkg fw green bean mgkg fw slight exceed mpcs mgkg fw leafi veget relat higher concentr al ba cr cu fe mn compar fruit veget maiz estim daili intak valu tm estim crop found toler daili intak valu target hazard quotient tms crop exceed accept non carcinogen risk level howev hazard index hi valu tomato found threshold valu indic non carcinogen risk consum due intak combin tms tomato thq valu co pb contribut hi valu tomato respect high daili consumpt amount tomato like result high hi valu find obtain studi reveal even level tms veget safe attent paid non carcinogen risk associ tms result high veget intak | D001151;D019216;D012989 | T131;T121;T196 |
34,687,750 | design health impact function assess margin chang outdoor fine particul matter estim health benefit improv ambient air qualiti requir character magnitud shape associ margin chang exposur margin chang risk uncertainti sever attempt made requir differ assumpt includ log linear integratedexposur respons ier globalexposuremortalitymodel gemm paper develop improv relat risk model suitabl use health benefit analysi incorpor featur exist model address limit model model deriv relat risk function within meta analyt framework quantiti direct applic benefit analysi incorpor fusion algebra function use previous model assum constant deriv concentr low exposur like model declin deriv moder exposur observ cohort studi deriv declin invers concentr high global exposur similar manner gemm model properti illustr exampl fit data six specif caus death previous examin globalburdenofdiseas program ambient fine particul matter pm test case analysi assum benefit analysi burden analysi reduct countri specif fine particul matter concentr correspond estim global attribut death use fusion model found lie ier model gemm estim similar base model | D000393;D000397 | T131;T069;T080 |
34,687,749 | pediatr refer interv routin biochem marker use siemen healthin atellica ch assay healthi children adolesc pediatr refer interv essenti test interpret develop newer analyt system de novo refer interv establish necessari import current studi pediatr refer interv determin analyt use siemen healthin atellica ch assay calip cohort healthi children adolesc | D001774;D016208;D012727 | T032;T170;T059 |
34,687,748 | etiolog chronic atrioventricular block young adult public univers hospit india young adult chronic atrioventricular av block scant systemat document india prospect studi includ patient year old present av block without revers caus patient age year male patient complet av block narrow qrs escap rhythm rate beatsmin three patient ana posit patient anti ds dna posit esr crp level mild elev patient respect rest test unremark despit perform multipl test etiolog remain idiopath | D054537;D010138 | T074;T047 |
34,687,747 | inhibit return time laps brain rhythm grip forc control spatial attent inhibit return ior observ slow respons target cu posit cue target interv longer ms enough time disengag previous cu locat inhibitori effect observ studi aim understand whether mechan under ior act perceptualattent later respons execut stage offer diverg result though focus brain respons cue target interv offer signific inform natur ior studi investig neural activ interv studi suggest generat inhibitori tag spatial coordin previous attend posit turn inhibit motor program toward posit cue target task administ studi rhythmic activ eeg signal entir cue target interv measur determin whether ior refer earli late respons process stage visual guid forc variat isometr contract instead key press respons requir reduc effect motor respons initi result indic promin involv fronto pariet occipit cortic area post cue appear peculiar theta band modul character posterior pariet cortex theta activ region enhanc post cue onset decreas time enhanc target appear unexpect locat rather cu posit suggest mechan generat ior sequenti affect perceptualattent process motor prepar rather respons execut | D001288;D003463 | T041;T078 |
34,687,746 | oncogen kit induc replic stress confer cell cycl checkpoint vulner melanoma acral mucos melanoma aris sun protect site disproportion impact darker skin individu exact higher mortal common type cutan melanoma genet acral mucos melanoma harbor alter kit typic cutan melanoma kit mutat melanoma remain larg treatment resist set creat faith murin kit driven allograft model defin newer therapeut strategi use preval human kit ke activ mutat murin mkit ke cellular avatar show featur transform vitro tumorigen immunocompet cblj mice mkit ke cell prolifer rapid exhibit greater chromosom aberr sustain three dimension spheroid expans aggress tumor growth cblj mice compar vector control cell verifi function depend cell kit ke genet pharmacolog suppress use cell perform screen kinas inhibitor identifi select vulner chkatr inhibit kit ke activ cell mechanist subsequ show kit ke induc signific increas level replic stress compar murin vectorcontrol cell result showcas allograft model human kit driven melanoma uncov unappreci role replic stress kit melanomagenesi implic possibl therapeut strategi chkatr inhibitor | D008545;D012878 | T191 |
34,687,745 | vemurafenib drive epitheli mesenchym transit gene express braf inhibitorresist braf nras qk melanoma enhanc tumor growth metastasi bioluminesc murin model braf inhibitor brafi resist compromis long term survivorship patient malign melanoma mutant nras major mediat brafi resist studi employ phenotyp transcriptom analysi isogen melanoma cell differ nras mutat status brafi sensit braf nras q vs brafi resist braf nras qk show brafi vemurafenib treatment select target braf nras qk cell upregul epitheli mesenchym transit emt gene express paradox promot invas metastasi vitro vivo first nanostr ncounter transcriptom analysi identifi upregul specif gene express network emt emt metastasi function nras qk status strike brafi treatment exacerb upregul gene promot emt braf nras qk cell oppos downregul emt driver gene braf nras q genotyp detect emt focus rt profil qpcr array analysi braf nras qk cell brafi treatment enhanc prolifer invas togeth activ phosphoryl protein kinas b ser oppos phenotyp effect observ braf nras q cell display downregul phosphoryl protein kinas b phosphoryl extracellular signal regul kinas scid mous bioluminesc melanoma metastasi model brafi treatment enhanc lung tumor burden impos braf nras qk cell block braf nras q metastasi preclin data document brafi driven enhanc tumorigenesi metastasi brafi resist human braf nras qk melanoma find potenti clinic implic patient nras driven brafi resist tumor receiv brafi treatment | D008545;D048493 | T191;T116;T126 |
34,687,744 | adipocyt deriv ctrp exhibit anti inflammatori effect via lamp stat axi psoriasi psoriasi system diseas associ metabol disord may contribut abnorm adipokin level howev under mechan larg unknown investig role adipokin ctrp pathogenesi psoriasi comorbid circul ctrp level patient psoriasi signific lower healthi control negat correl metabol risk factor rescu ctrp level glp receptor agonist exendin diet induc obes mice could allevi sever psoriat symptom imiquimod induc mous model topic applic ctrp also exert protect effect imiquimod induc normal diet mice moreov ctrp could direct inhibit inflammatori respons psoriat keratinocyt block phosphoryl signal transduc activ transcript via lamp vitro identifi critic psoriat cytokin includ il tnf impair adipocyt differenti suffici ctrp secret sum studi reveal adipocyt dysfunct low level ctrp caus il exacerb psoriasi progress relat metabol syndrom impli mechan under vicious cycl psoriasi metabol disord pharmacolog agent improv ctrp level obes patient psoriasi may consid potenti strategi psoriasi treatment | D020381;D011565 | T116;T047;T123;T129;T192 |
34,687,743 | methylom transcriptom analysi normal human scar cell reveal role foxf scar mainten scar maintain life increas size period growth puberti epigenet chang fibroblast injuri may underpin mainten growth scar studi combin methylom transcriptom data normotroph matur scar contralater uninjur normal skin fibroblast identifi potenti regul scar mainten total signific differenti express signific differenti methyl promot identifi gene signific differenti methyl express two transcript factor foxf mkx select analysi immunocytochemistri qpcr suggest foxf mkx elev express scar fibroblast use rna sequenc foxf knockdown shown signific reduc express extracellular matrixrel gene wherea mkx appear affect similar pathway final foxf knockdown also shown signific decreas collagen product scar keloid fibroblast studi provid insight mainten normotroph scar suggest foxf import regul process target gene respons mainten scar phenotyp may amelior scar appear improv patient outcom futur | D017439;D007627 | T020 |
34,687,742 | plcpkc downstream signal control cutan cell lymphoma develop progress develop mechanist rational improv clinic manag cutan cell lymphoma consider genet biolog evid malign network signal mechan high influenc deregul tcrplc activ control biolog lesion addit activ signal transduc activ transcript associ clinic progress although alter respons fulli elucid studi plc depend mechan mediat stat activ control tumor growth progress downstream plc pharmacolog inhibit genet knockdown protein kinas c theta pkc inhibit signal transduc activ transcript activ impair prolifer promot apoptosi cutan cell lymphoma cell pkc depend transcriptom mycosi fungoidesszari syndrom cell reveal potenti effector gene control cytokin signal tp actin cytoskeleton dynam consist vivo chicken embryo model xenograft mycosi fungoid cell show pkc blockag abrog tumor growth spread distant organ final express number pkc target gene found mycosi fungoid cell signific correl prkcq pkc human mycosi fungoid sampl summari pkc play central role activ malign cutan cell lymphoma mechan via multipl rout includ restrict stat mechan may turn serv target specif therapi | D016410;D009182;D012878 | T191 |
34,687,741 | implic stabl increas adenoma detect rate need continu measur measur adenoma detect rate adr resourc intens benefit continu measur colonoscopist high adr unclear examin adr trend center determin whether continu measur consist high adr warrant | D000236;D015179 | T191 |
34,687,735 | fit thermodynam base model incorpor paramet sensit improv perform evolutionari algorithm detail comprehens transcript regul critic understand genet control develop diseas across mani differ organ fulli investig complex molecular interact control precis express gene mani group construct mathemat model complement experiment approach critic step studi choos appropri paramet estim algorithm enabl detail analysi paramet contribut model studi develop novel set evolutionari algorithm use pseudo random sobol set construct initi popul incorpor paramet sensit adapt mutat rate use local global hybrid strategi comparison perform new algorithm number current state art global paramet estim algorithm rang continu test function well synthet biolog data repres model gene regulatori system reveal improv perform new algorithm term runtim error reproduc addit analyz abil algorithm fit dataset vari qualiti provid experimentalist guid algorithm perform across rang noisi data result demonstr improv perform new set paramet estim algorithm facilit meaning integr model paramet predict understand molecular mechan gene regul | D000465;D008954 | T170;T075 |
34,687,733 | symptomolog follow mrna vaccin sar cov despit demonstr efficaci vaccin sever acut respiratori syndrom coronavirus sar cov causat agent coronavirus diseas covid widespread hesit vaccin persist improv knowledg regard frequenc sever durat vaccin associ symptom may help reduc hesit prospect observ studi studi healthcar worker receiv dose pfizer biontech sar cov mrna vaccin complet post vaccin symptom survey dose dose defin appreci post vaccin symptom least moder sever last least day found symptom frequent follow second vaccin dose first vs p symptom resolv within day common symptom inject site pain follow fatigu malais overal particip experienc appreci symptom dose dose multivari analys femal sex associ greater odd appreci symptom dose ci dose prior covid also associ appreci symptom follow dose younger age histori hypertens associ appreci symptom dose conclud post vaccin symptom report mild last day appreci post vaccin symptom associ femal sex prior covid younger age hypertens inform aid clinician advis patient safeti expect symptomatolog associ vaccin | D000086382;D000086402 | T047;T005;T067 |
34,687,732 | prenat cannabi use disord futur risk road traffic injuri canadian children extent child traffic injuri may attribut parent use cannabi drive unknown investig whether prenat cannabi use disord may predict futur road traffic injuri children conduct cohort studi children quebec canada year follow main exposur measur matern cannabi use disord pregnanc main outcom measur futur hospit transport relat injuri children birth use cox proport hazard regress model adjust potenti confound estim hazard ratio confid interv ci associ prenat cannabi use disord transport relat injuri children matern cannabi use disord birth associ time risk hospit futur motor vehicl crash injuri children ci risk increas child age prenat cocain opioid drug use disord associ pediatr transport relat injuri matern cannabi use disord birth may earli predictor childhood injuri motor vehicl crash | D002188;D002189;D019966 | T047;T121;T002;T109;T167;T048;T033 |
34,687,731 | impact prescript drug monitor program polici chang counti opioid safeti coalit prescrib overdos outcom california california receiv fund implement prescript drug overdos prevent initi year program reduc death involv prescript opioid leverag improv california prescript drug monitor program pdmp ie mandatori pdmp registr prescrib pharmacist support counti opioid safeti coalit use statewid data evalu initi impact opioid prescrib overdos rate prescrib data obtain california pdmp fatal non fatal overdos data obtain california depart public health outcom month opioid prescrib rate opioid overdos rate model use general linear mix model exposur mandatori pdmp registr presenc counti coalit initi support counti coalit mandatori pdmp registr associ decreas ci opioid prescrib rate month counti coalit associ decreas ci opioid prescrib rate receiv initi support associ addit decreas ci mandatori pdmp registr counti coalit associ decreas ci decreas ci respect prescript opioid overdos death intervent also associ signific fewer death involv opioid signific associ non fatal overdos rate find add knowledg avail guid polici prevent high risk prescrib opioid overdos studi need coalit mandatori pdmp registr may import compon effort | D062787;D000073958 | T058;T037 |
34,687,730 | life simpl risk stroke finnish men prospect cohort studi popul wide prevent measur constitut import approach toward reduc stroke risk associ burden sought examin associ american heart associ aha life simpl ls score risk stroke men | D002545;D002318;D020521 | T047;T046 |
34,687,729 | prevent paradox stroke multipl potenti risk factor use data popul base cohort studi previous studi found prevent paradox associ stroke event singl specif risk factor indic popul base strategi may effect high risk base strategi prevent test hypothesi prevent paradox appli focus multipl potenti risk factor simultan studi cohort includ individu japan age year time depend cox proport hazard model use identifi primari risk factor associ stroke onset classifi particip base risk factor two distinct way classifi high risk group particip accord singl specif risk factor larg associ stroke sex age classifi high risk group particip accord risk factor includ hypertens hyperglycemia andor dyslipidemia compar proport total number particip develop stroke group assess prevent paradox found hypertens primari risk factor stroke incid regardless sex age percentag patient singl specif risk develop stroke percentag patient risk factor find lead conclus prevent paradox hold multipl stroke risk factor associ suggest high risk base strategi focus patient multipl risk factor may effect prevent stroke | D006973;D020521 | T047 |
34,687,728 | risk factor multipl metabol syndrom compon obes non obes japanes individu mani studi report even non obes individu multipl metabol syndrom met compon hypertens hyperglycemia lipid abnorm higher cardiovascular diseas mortal rate incid howev risk factor multipl met compon non obes individu suffici clarifi studi compar risk factor includ overal lifestyl habit multipl met compon possess obes non obes individu cross section studi conduct use data specif health checkup individu age year belong health insur societi five manufactur compani japan multipl logist regress analysi conduct non obes obes group multipl met compon object variabl attribut bodi weight chang lifestyl habit smoke exercis diet drink sleep explanatori variabl group men older age current smoke weight gain kg sinc age slow walk speed fast eat speed greater amount alcohol consumpt risk factor multipl met compon odd ratio risk factor except walk speed eat speed tend higher non obes individu obes individu risk factor specif obes individu lack regular exercis result suggest almost risk factor possess multipl met compon common obes non obes individu risk level risk factor tend higher non obes individu | D024821 | T047 |
34,687,727 | daili transient coat intestin lead weight loss improv glucos toler roux en gastric bypass surgeri rygb shown gold standard treatment obes associ type diabet td howev mani td patient qualifi reluct proceed surgeri due potenti risk perman chang gi anatomi previous describ novel oral formul luci provid transient coat proxim bowel mimic effect rygb herein aim investig outcom chronic luci administr weight glucos homeostasi | D001786;D007422 | T023;T109 |
34,687,726 | gerosci motiv approach treat alzheim diseas senolyt move clinic trial pathogen process drive alzheim diseas ad complex incomplet understand under diseas mechan present insurmount obstacl develop effect diseas modifi therapi advanc chronolog age greatest risk factor develop ad interven biolog age may alter diseas progress repres novel complementari approach current strategi toward end cellular senesc emerg promis target complex stress respons harbor damag cell cell cycl arrest apoptosi resist cell state senesc cell accumul age notori secret molecul contribut chronic tissu dysfunct diseas thus benefit cell surviv senesc fate counter toxic secretom remov senesc cell improv brain structur function rodent model risk develop ad advanc tau patholog present review describ path translat promis treatment strategi ad clinic trial review evid senesc cell accumul human brain consider strategi senesc target trial specif ad approach detect senesc brain cell biofluid summar goal first senolyt trial treatment ad nct nct articl part special issu senolyt edit joao passo diana jurk | D000375;D000544 | T040;T033;T048;T047 |
34,687,723 | repair broken heart pluripot stem cell deriv cardiomyocyt heart regener address central problem cardiolog irrevers loss myocardium eventu lead heart failur true restor heart function achiev remuscular ie replac lost myocardium new forc develop heart muscl avail princip unlimit human cardiomyocyt pluripot stem cell one option remuscular injur heart produc larg number cardiomyocyt plusminus cardiovascular cell type progenitor ex vivo appli heart either inject applic patch excit progress past decad led first clinic applic import question remain academ increas corpor activ ongo answer optim approach final develop true regen therapi heart failur | D006333;D039904 | T025;T047;T046 |
34,687,722 | impact chromosom organ epigenet drift domain stabil reveal physic base simul examin relationship size domain epigenet mark stabil domain use theoret model captur physic mechan govern mainten epigenet modif focus studi histon h lysin trimethyl one common consequenti epigenet mark role chromatin compact gene repress model combin effect methyl spread methyltransferas chromatin segreg heterochromatin euchromatin preferenti heterochromatin protein hp bind model indic although larg methyl domain pass success one chromatin generat next small alter methyl sequenc maintain chromatin replic use predict model investig size requir epigenet domain persist chromatin generat surround much larger domain opposit methyl compact state find critic size threshold hundr nucleosom scale epigenet domain reliabl maintain generat precis size threshold differ heterochromat euchromat domain result consist natur alter epigenet sequenc occur embryon develop due age relat epigenet drift | D000090266;D044127;D040961;D006570 | T026;T116;T045 |
34,687,721 | comput model e cadherin cluster forc e cadherin play critic role format cell cell adhes sever physiolog function includ tissu develop repair homeostasi format cluster e cadherin involv extracellular adhes tran later cis associ e cadherin ectodomain stabil intracellular bind actomyosin cytoskeleton bind provid forc adhes requir mechanotransduct howev exact role cytoskelet forc cluster e cadherin well understood gain insight mechan develop comput model base brownian dynam model e cadherin transit structur function state abl bind unbind e cadherin andor opposit cell tran cis interact also creat dynam link actomyosin cytoskeleton result show actomyosin forc govern fraction e cadherin cluster size number cluster low forc pn larg number small e cadherin cluster form less five e cadherin higher forc probabl form fewer larger cluster increas find support idea forc reinforc cell cell adhes consist differ cluster size previous observ apic later junction epitheli tissu | D015820;D040542 | T044;T116;T123 |
34,687,720 | optim microtubul arrang rapid cargo captur cellular function autophagi cell signal vesicular traffick involv retrograd transport motor driven cargo along microtubul typic newli form cargo engag slow undirect movement point origin attach microtubul cell type cargo destin deliveri perinuclear region reli captur dynein enrich load zone locat near microtubul plus end system includ extend cell region neurit fungal hypha effici initi diffus load process depend axial distribut microtubul plus end relat initi cargo posit use analyt mean first passag time calcul numer simul model diffus captur process tubular cell explor spatial arrang microtubul plus end affect effici retrograd cargo transport model delin key featur optim microtubul arrang minim mean cargo captur time name show configur singl microtubul plus end abut distal tip broad distribut plus end allow effici captur varieti differ scenario retrograd transport live cell imag microtubul plus end aspergillus nidulan hypha indic distribut exhibit optim qualit featur result highlight import coupl effect distribut microtubul tip retrograd cargo transport provid guid principl spatial arrang microtubul within tubular cell region | D001233;D008870 | T004;T026 |
34,687,719 | hdanm new comprehens dynam model protein hing hing motion essenti mani protein function dynam import understand under biolog mechan way motion repres various comput method differ signific focus specif class motion develop new hing domain anisotrop network model hdanm base prior identif flexibl hing rigid domain protein structur subsequ generat global hing motion yield set motion relat translat rotat rigid domain modul control deform flexibl hing lead restrict specif view motion hdanm first model knowledg combin inform protein hing domain model characterist hing motion protein motion predict new elast network model provid import conceptu advantag understand under biolog mechan matter fact generat hing movement found resembl expect mechan requir biolog function divers protein anoth advantag model domain level coars grain make signific comput effici enabl generat hing motion within even largest molecular assembl cryo electron microscopi hdanm also comprehens perform way well known protein dynam model anisotrop network model rotat translat block nonlinear rigid block normal mode analysi depend definit flexibl rigid part protein structur whether motion extrapol linear nonlinear fashion furthermor result indic hdanm produc realist motion compar anisotrop network model hdanm open sourc softwar freeli avail host user friend websit | D000465;D011506 | T116;T170;T123 |
34,687,718 | mesoscal mechan model cellular interact comput model cell mechan allow precis interrog cell shape chang morpholog chang requir cell surviv divers tissu environ present mesoscal mechan model cell substrat interact use level set method base experiment measur paramet implement viscoelast mechan equival circuit accur model whole cell deform import varieti cellular process effect model shape chang cell interact substrat includ receptor mediat adhes govern catch slip bond behavior effect adhes explor subject cell varieti differ substrat includ flat curv deform surfac final increas accuraci simul includ deform nucleus cell model set foundat explor comput analys multicellular interact | D002450;D002467 | T043;T026 |
34,687,717 | long rang dna water interact dna function aqueous environ adopt differ conform depend hydrat level dynam hydrat water hydrat dna lead rotat oscil dipol turn give rise strong megahertz terahertz absorpt investig impact hydrat dna dynam spectral featur water molecul influenc dna howev extrem challeng strong absorpt water megahertz terahertz frequenc rang respons employ high precis megahertz terahertz dielectr spectromet assist molecular dynam simul investig dynam water molecul within hydrat shell dna well collect vibrat motion hydrat dna vital dna conform function result reveal dynam water molecul dna solut heterogen exhibit hierarchi four distinct relax time rang ps ns hydrat structur dna chain extend far surfac low frequenc collect vibrat mode hydrat dna identifi found sensit environment condit includ temperatur hydrat level result reveal critic inform hydrat dna dynam dna water interfac impact biochem function reactiv dna | D056004;D014867 | T044;T066;T121;T197 |
34,687,716 | influenc sexual dimorph venom composit bothrop asper crotalus simus serpent viperida potenti implic snake antivenom product work aim bring insight potenti sexual dimorph differ venom composit bothrop asper crotalus simus expand knowledg venom variabl might improv antivenom design biolog character venom sex speci show signific qualit differ consider sexual venom variat speci relev choos snake donor venom product | D017837;D003435;D017819 | T116;T109;T123;T131;T014 |
34,687,715 | combin ancestr reconstruct fold landscap simul engin heterolog protein express oblig symbiont typic exhibit high evolutionari rate consequ protein may differ consider modern ancestr homolog term sequenc properti thus provid excel model studi protein evolut also oblig symbiont challeng cultur lab protein uncultur organ must produc heterolog host use recombin dna technolog oblig symbiont thus replic fundament scenario metagenom studi aim function character biotechnolog exploit protein bacteria soil use thioredoxin candidatus photodesmus katoptron uncultur symbiont flashlight fish explor evolutionari engin aspect protein fold heterolog host symbiont protein standard thioredoxin term structur stabil redox activ howev fold outsid origin host sever impair shown slow refold vitro ineffici express e coli lead most insolubl protein contrast resurrect precambrian thioredoxin express effici e coli plausibl reflect ancient adapt unassist fold use statist mechan model fold landscap guid back ancestor engin symbiont protein remark find effici heterolog express correl vitro ie unassist fold rate ancestr express effici achiev back ancestor replac result demonstr minim perturb sequenc engin approach rescu ineffici heterolog express may potenti use metagenom effort target recent adapt | D017510 | T044 |
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