PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,687,569 | disturb alter forest soil microbiom billion microorgan perform critic ground function terrestri ecosystem larg invis nake eye support higher lifeform form symbiot relationship terrestri plant speci stabil soil facilit biogeochem cycl global increas frequenc disturb drive major chang structur function forest howev despit function signific disturb respons forest microbi communiti poor understood explor influenc disturb soil microbiom archaea fungi bacteria world tallest carbon dens forest mountain ash forest south eastern australia site identifi microbi oper taxonom unit cm cm depth soil respect extens data set found divers composit often cryptic communiti alter human natur disturb event instanc divers ectomycorrhiz fungi declin clearcut log divers archaea declin salvag log bacteri divers overal microbi divers declin number fire moreov identifi key associ edaph soil properti environment slope elev spatial variabl composit microbi communiti specif found soil ph manganes magnesium phosphorus iron nitrat associ composit microbi communiti period widespread degrad global forest ecosystem find provid import time insight disturb respons soil microbi communiti may influenc key ecolog function | D005390;D064307;D038821 | T004;T001;T032;T028;T067 |
34,687,568 | biosynthesi aminobutyr acid lactic acid bacteria surplus bread use bread make aim studi investig effect bread substrat aminobutyr acid gaba biosynthesi establish valor strategi surplus bread repurpos within food chain | D001939;D056546 | T007;T168 |
34,687,567 | effect human serum albumin fluoresc intens tumor imag properti ir dye ir lipophil dye excel optic tumor imag properti earli tumor diagnost although mechan tumor target fulli identifi view serum albumin play import role tumor accumul recogn mechan interact ir hsa studi explor effect albumin tumor target properti data demonstr ir tight adsorb hsa ratio form noncoval complex exhibit signific improv near infrar fluoresc imag tumor diagnosi capac process endogen fluoresc esteras activ hsa partial inhibit ir helic content hsa slight increas molecular dock simul display bind site ir hsa subdomain iia iib result indic hsa import factor mediat optic perform ir give higher tumor diagnosi capabl | D009369;D000075462 | T191;T121;T116 |
34,687,565 | heal surgic retreat four time point retrospect studi evalu outcom surgic retreat four time point month post oper search prognost factor may affect outcom | D018915;D012390 | T061 |
34,687,564 | antimicrobi effect melaleuca alternifolia tea tree essenti oil biofilm form multidrug resist cystic fibrosi associ pseudomona aeruginosa singl agent combin common nebul antibiot broth microdilut assay use determin minimum inhibitori concentr mic fraction inhibitori concentr indic fici tea tree oil tto tobramycin colistin aztreonam atm clinic cystic fibrosi associ pseudomona aeruginosa cfpa isol n minimum biofilm erad concentr mbec fraction biofilm erad concentr index fbeci also determin use similar microbroth dilut checkerboard assay biofilm form use mbec devic tto effect lower concentr multidrug resist mdr cfpa isol n biofilm compar plankton state mbec fold lower mic cfpa within biofilm less suscept atm colistin tobramycin compar plankton cell mbec fold fold fold higher mic respect combin essenti oil antibiot show indiffer relationship fici test plankton mdr cfpa isol n cfpa isol n biofilm combin ttoaztreonam ttocolistin show indiffer relationship mean fbeci respect wherea ttotobramycin show synergist relationship mean fbeci antibiofilm properti tto synergist relationship seen tto tobramycin cfpa vitro make inhal tto promis candid potenti therapeut agent | D003550;D031650;D009822;D020947 | T047;T121;T002;T109 |
34,687,563 | phenol rich extract acerola cashew appl mango product caus divers inhibitori effect cell damag enterotoxigen escherichia coli studi aim evalu inhibitori effect phenol rich extract acerola malpighia emarginata dc pea cashew appl anacardium occidental l pec mango mangifera indica l pem product distinct enterotoxigen escherichia coli etec strain capabl pea pec impair various physiolog function etec strain investig multiparametr flow cytometri procyanidin b myricetin p coumar acid major phenol compound pea pec pem respect pea pec lower minimum inhibitori concentr mic minimum bactericid concentr mbc mic mg ml mbc mg ml etec strain pem mic mic mg ml pea pec mg ml caus viabl count reduct p etec strain h exposur notabl log reduct caus mg ml h exposur etec strain pea pec mg ml led high size cell subpopul concomit impair cell membran polar permeabl well enzymat respiratori efflux activ pea pec effect inhibit etec multi target action mode disturb differ physiolog function | D031021;D054307;D004927;D031022 | T047;T007;T002;T168 |
34,687,562 | franz joseph gall god religion dieu et cerveau rien que dieu et cerveau franz joseph gall doctrin mani faculti mind correspond cortic organ led accus materi fatal even atheism yet littl written specif charg felt forc respond vienna visit german state pari publish book articl examin accus gall respons also look gall wrote cortic faculti god religion see intellig design function organ brain addit present glean privat thought god organ religion conclud gall sincer admir belief god creator enlighten scientist recogn need separ metaphys law natur present new scienc man | D010792 | T170 |
34,687,560 | benefit late read patch test depend allergen patient characterist patch test pt read recommend h h addit day read suggest although data effici patient select scarc investig posit reaction regard allergen baselin seri addit pt seri german contact dermat research group dkg ii characterist patient test | D000485;D017449 | T129;T047 |
34,687,559 | evalu neonat cerebr perfus use three dimension power doppler ultrasound volum despit improv preterm surviv neurolog morbid remain high fraction move blood volum fmbv quantifi neonat cerebr perfus calcul standardis measur amount move blood region interest correl tissu perfus anim studi howev feasibl reproduc yet assess newborn infant | D007234;D018608 | T033;T100;T060 |
34,687,558 | meta analysi systemat review preval graft failur mortal post oper thrombosi liver transplant recipi pre oper portal vein thrombosi studi seek evalu associ pre transplant portal vein thrombosi pvt overal surviv graft failur waitlist mortal post oper pvt liver transplant | D008107;D016031;D020246 | T033;T047;T061;T046 |
34,687,557 | evolutionari diverg embryo seed coat develop u triangl brassica speci illustr spatiotempor transcriptom atlas econom valuabl brassica speci includ six relat member u triangl despit agronom econom import brassica impact evolut relat recent domest event genet landscap seed develop comprehens examin speci present transcriptom atlas six speci u triangl produc uniqu resourc captur gene express data major subcompart seed unfertil ovul matur embryo seed coat comprehens dataset seed develop tetraploid ancestr diploid brassica provid new insight evolutionari diverg express bias gene subgenom level domest valu crop speci comparison gene express associ regulatori network metabol pathway oper embryo seed coat seed develop reveal differ storag reserv accumul fatti acid metabol among six brassica speci studi illustr genet underpin seed trait select pressur place seed product provid immens resourc continu investig brassica polyploid biolog genom evolut | D001937;D029688 | T002;T168 |
34,687,556 | burnout mft traine impact demand resourc burnout defin state physic mental emot exhaust caus involv emot demand work occup risk help profess signific negat consequ studi examin burnout among couplemarriag famili therapi cmft traine associ various demand resourc individu practic relat level well variabl specif traine status data came onlin studi cmft traine state enrol coupl famili therapi graduat program nationwid half particip report various level burnout indic issu burnout merit special attent cmft educ supervisor signific factor associ burnout relat train context includ supervis satisfact hour spent set caseload dissatisfact find implic supervis discuss context cmft train | D002055 | T048 |
34,687,555 | clinic util liquid biopsi breast cancer systemat review advanc genet sequenc techniqu along identif specif mutat structur chang multipl cancer gene make possibl identifi circul tumor cell cell free nucleic acid blood base biomark serv liquid biopsi lb great util diagnosi treatment follow patient neoplasm systemat review focus clinic util lb patient breast cancer bc articl publish includ databas search trip databas wos embas pubm scopus clinic key variabl studi public year countri number case primari studi design lb detect method gene found overal surviv diseas free surviv stage respons treatment clinic util bc molecular type system treatment methodolog qualiti primari studi articl retain repres patient main cohort studi major china japan primari studi describ clinic stage type system treatment use use biomark detect method dna type analysi quantif total cfdna pikca mutat frequent evid suggest clinic use applic bc though heterogen public suggest lb constitut part standard diagnost therapeut process bc | D001943;D000073888 | T191;T114;T123 |
34,687,554 | applic metal nanomateri treatment water water scarciti novel issu alreadi affect almost everi contin blue planet driven two primari sourc increas demand fresh water due increas popul overexhaust avail freshwat resourc past decad stress given extract fresh clean safe potabl elixir life bounti store sea water exploit various technolog nanomateri provid promis solut almost problem access order combat problem global freshwat scarciti desalin method marvel improv impact nanomateri differ metal nanomateri use serv purpos exampl silver iron zinc titanium dioxid addit natur synthet deriv polymer bionanomateri present paper brief account metal nanomateri use treatment water provid thorough investig research done till strive throw light various materi method base exploit nanotechnolog treatment water | D049329;D018508 | T052;T057;T073 |
34,687,553 | poor protect potenti influenza nucleoprotein antibodi despit wide preval human expos influenza virus period infect due repeat exposur human popul common elev antibodi titer target conserv intern influenza virus nucleoprotein np despit presenc anti np antibodi human acut suscept drift influenza virus antigen differ surfac protein protect potenti human np antibodi unclear studi high level anti np antibodi np specif b cell detect adult human influenza infect mice confirm np major target humor immun sort singl b cell influenza expos human adult generat panel anti np monoclon antibodi mab major anti np human mab generat capabl engag cellular fc receptor bound np surfac influenza infect cell line vitro suggest anti np mab potenti mediat downstream fc effector function antibodi depend cellular cytotox antibodi depend phagocytosi howev human anti np mab protect vivo passiv transfer murin influenza challeng model futur vivo studi examin synergist effect anti np mab infus influenza specif mab warrant | D007252;D007251;D009976 | T129;T047;T121;T109 |
34,687,552 | usag cyanobacteria wastewat treatment prospect limit applic cyanobacteria execut various role treatment wastewat assembl superflu food thus produc valu biomass various applic besid enrich improv qualiti water photosynthet autotroph current cyanobacteria gain momentum remedi wastewat first enhanc content water photosynthesi perform bioremedi heavi metal second cyanobacteria play signific role distress biolog oxygen demand chemic oxygen demand turbid miner microb third use either axen cultur mix cultur offer distinct advantag last speci toler toward extrem temperatur low high acid ph high salt concentr heavi metal make outstand candid wastewat treatment plant suitabl immobil method must evolv better understand morpholog biochem paramet requir optimum growth easi method harvest biomass treatment requir trial larg scale basi requir launch full fledg basi wastewat treatment | D000458;D019216 | T007;T196 |
34,687,551 | common ugta polymorph clinic meaning impact appar oral clearanc dapagliflozin type diabet mellitus dapagliflozin inhibitor human renal sodium glucos cotransport sglt first approv treatment type diabet mellitus tdm dapagliflozin primarili metabol uridin diphosph glucuronosyltransferas ugta effect ugta polymorph dapagliflozin appar oral clearanc clf studi dapagliflozin popul pharmacokinet data ugta genotyp data ic rs rs rs rs ugta ugta phase studi conduct subject tdm n analysi covari ancova model account known covari influenc dapagliflozin clf appli data quantifi impact ugta polymorph relat wildtyp ugta genotyp analysi show geometr mean ratio dapagliflozin clf ugta polymorph studi within rang wildtyp ugta clf valu consequ polymorph ugta studi clinic meaning impact clf dapagliflozin | D003924;D000077203 | T047;T121;T109 |
34,687,550 | leverag survey claim data identifi high need medicar beneficiari nation health age trend studi multipl algorithm develop identifi character high need hn medicar popul howev vari compon yield differ popul develop vari purpos compar perform exist survey claim base definit identifi hn beneficiari predict poor outcom among communiti dwell popul | D015897 | T033 |
34,687,547 | silico genom wide gene base associ analysi reveal new gene predispos coronari arteri diseas genom wide associ studi gwas identifi singl nucleotid polymorph independ loci associ coronari arteri diseas cad howev full understand causal gene cad mechan action aim perform post gwas analysi identifi gene whose polymorph may influenc risk cad use uk biobank gwas summari statist perform gene base associ analysi found gene signific associ cad due within gene polymorph mani gene well known known cad gene furin sort show gene base associ variant low gwas signal gene base associ inflat strong gwas signal outsid gene sever known cad gene demonstr effect could explain variant variant within neighbor gene control express use sever bioinformat techniqu suggest potenti mechan under gene cad associ three gene cdk ncald arhgef previous associ cad role gene clarifi studi | D000483;D020022 | T032;T028 |
34,687,545 | cormatrix vessel reconstruct paediatr cardiac surgeri word caution aim retrospect studi determin cormatrix cm repres safe altern convent patch materi use congenit heart surgeri | D006348;D006330 | T019;T061 |
34,687,543 | standard workflow precis mid high throughput proteom blood biofluid accur discoveri assay workflow critic identifi authent circul protein biomark divers blood matric maxim common proteom workflow differ biofluid simplifi approach increas likelihood reproduc develop workflow accommod blood base proteom naiv plasma deplet plasma dri blood | D001769;D040901;D057188 | T091;T031;T077 |
34,687,541 | impact atrial fibril stroke risk factor left atrial blood flow characterist alter left atrial la blood flow characterist account increas cardioembol stroke risk atrial fibril af aim assess whether exposur stroke risk factor suffici alter la blood flow even presenc sinus rhythm sr | D020517;D001281;D020521 | T047;T023;T046 |
34,687,538 | reduc global longitudin strain marker earli detect fabri cardiomyopathi fabri cardiomyopathi fc character progress left ventricular hypertrophi lvh convent echocardiographi sensit detect preclin fc develop lvh aim investig whether myocardi deform analysi use detect preclin fc lvh | D009202;D017379 | T047 |
34,687,535 | surgic manag fail fontan circul result case patient year follow fontan patient known suffer clinic attrit year character fontan failur sought evalu clinic outcom fontan patient undergo surgic manag year singl centr experi | D018729;D006330;D016027 | T019;T042;T061 |
34,687,534 | dimension comput tomograph assess predict conduct block paravalvular leakag rapid deploy aortic valv replac complic like complet atrioventricular block cavb paravalvular leakag pvl follow rapid deploy aortic valv av replac rdavr remain unresolv select optim size valv might import minim incid complic sought determin impact prosthesi size relat anatom profil av occurr cavb pvl rdavr | D001024;D006350;D019918;D065467 | T074;T047;T061 |
34,687,532 | systemat review meta analysi effect portion size ingest frequenc energi intak bodi weight among adult random control feed trial energi intak product portion size ps energi content ingest event ingest frequenc number ingest event per unit time uncompens alter either ps would result chang energi intak bodi weight maintain time object meta analysi assess independ effect ps energi intak bodi weight among healthi adult random control trial rcts total articl identifi pubm web scienc cochran cinahl databas articl divid among research articl screen elig independ review exclus criteria includ popul unhealthi popul ie particip acut chronic diseas assess h wk durat trial investig energi intak bodi weight respect control feed trial ie fix energi intak manipul ps studi intervent ifp evalu separ bodi weight outcom twenti two studi ps ifp met inclus criteria insuffici number studi assess effect ps ifp bodi weight heterogen effect size among comparison consum larger portion size associ higher daili energi intak kcal n weight mean differ wmd ci n comparison increas frequenc ingest event associ higher energi intak kcal n result rcts support larger ps greater associ higher energi consumpt howev insuffici inform determin chronic effect bodi weight protocol regist intern prospect regist systemat review prospero crd | D002149;D064787 | T081 |
34,687,529 | comput tomographi cutan myiasi ornat box turtl terrapen ornata ornata juvenil intact femal ornat box turtl terrapen ornata ornata refer evalu right side appendicular swell nonrespons antimicrobi therapi comput tomographi ct reveal sever soft tissu swell limb neck multipl associ tortuous gas fill sinus tract extend cutan surfac contain oblong soft tissu attenu structur ct find consist migrat dipter larva surgic explor perform six sarcophagid larva superfamili oestroidea extract knowledg first case report veterinari medicin provid antemortem ct imag featur cutan myiasi reptil | D009198;D014426 | T047;T014 |
34,687,528 | present manag dental pad fractur two florida manate trichechus manatus latirostri florida manate trichechus manatus latirostri well develop keratin dental pad rostral aspect mouth assist mastic uniqu develop thought adapt respons high abras diet contain phytolith sediment may acceler dental wear may two florida manate present multipl fractur inferior dental pad fractur success manag nutrit modif dental pad trim vigil monitor behavior husbandri train sign spontan heal observ earli day initi present subsequ full resolut although surgic intervent plan spontan heal mitig signific health risk associ procedur author knowledg first report case dental pad fractur spontan heal resolut manate | D020457 | T015 |
34,687,527 | exocrin pancreat insuffici like syndrom four captiv tiger panthera tigri exocrin pancreat insuffici epi condit character decreas synthesi secret pancreat enzym result weight loss poor hair coat diarrhea diagnost test choic epi domest cat felin serum trypsin like immunoreact ftli paper detail four tiger panthera tigri clinic sign compat epi basi domest cat refer rang ftli assay four clinic affect tiger diagnost epi median gl rang gl four tiger rapid clinic respons pancreat enzym supplement serum clinic healthi tiger submit ftli assay compar purpos healthi tiger ftli assay also within rang diagnosi epi domest cat median gl rang gl howev clinic affect tiger signific lower serum ftli concentr healthi tiger p serum cobalamin detect limit affect healthi tiger ngl measur ftli appear use tool diagnosi epi like syndrom tiger speci epi like syndrom tiger may also associ cobalamin defici | D002371;D010188;D046010 | T015;T047 |
34,687,526 | detect ophidiomyc ophidiicola three file snake acrochordus granulatus import indonesia moscow zoo russia three file snake acrochordus granulatus deliv moscow zoo russia jakarta indonesia short arriv multipl white blister detect bodi three snake die within month arriv microscopi arthrospor mycelium seen exud lesion ophidiomyc ophidiicola isol two three snake identifi intern transcrib spacer sequenc dermatophyt test medium turn red posit cultur potenti employ detect ophidiicola causat agent snake fungal diseas first report ophidiicola russia second report case ophidiomycosi file snake possibl sourc ophidiicola snake import southeast asia discuss | D020036 | T004 |
34,687,525 | coelom steatiti tentacl snake erpeton tentaculatum retrospect studi reveal seven case coelom steatiti adult tentacl snake erpeton tentaculatum includ two male five femal may august common clinic sign includ death unusu float general weak inappet reduc bodi condit coelom distens reproduct patholog femal hematolog one specimen reveal mark monocytosi lymphocytosi mild heterophilia chronic activ inflamm gross examin identifi variabl degre intracoelom fat necrosi snake consist histopatholog featur includ necrot adipocyt lipid saponif lipofuscinceroid deposit granulomat inflamm multinucl giant cell langhan type three femal exhibit intralesion yolk fluid associ periovarian steatiti hepat lipidosi second frequent patholog find thaw frozen lesser sand eel ammodyt tobianus fed period store vacuum seal open packet c frozen death last specimen vitamin e concentr peroxid valu diet analyz seal open frozen batch respect vitamin e concentr mg g compar mg g averag fresh raw mix eel speci sampl peroxid valu meqkg exceed accept peroxid valu meqkg fish oil case studi repres first report coelom steatiti tentacl snake unconfirm etiolog putat associ feed long term frozen store sand eel diet contain low vitamin e concentr fish oil high peroxid valu time analysi | D017812;D013231 | T047;T014 |
34,687,524 | use ephedrin treat anesthesia associ hypotens pinnip hypotens common advers effect general anesthesia histor difficult measur pinnip speci due technic challeng retrospect case review found seven pinnip case demonstr anesthesia associ hypotens diagnos direct blood pressur measur general anesthesia marin mammal center sausalito ca case includ five california sea lion csl zalophus californianus one hawaiian monk seal hms neomonachus schauinslandi one northern eleph seal nes mirounga angustirostri patient induc use inject opioid benzodiazepin anesthet includ propofol alfaxalon exclud hms patient requir supplement isofluran mask achiev anesthet plane allow intub patient maintain inhal isofluran oxygen durat anesthet event patient concurr administ continu iv fluid four patient receiv fluid bolus prior administr ephedrin hypotens anesthet patient treat iv ephedrin mgkg averag initi systol sap mean map arteri blood pressur csl prior ephedrin administr mmhg mmhg respect averag sap map csl increas mmhg mmhg respect within ephedrin administr nes initi blood pressur measur sapdiastol map mmhg increas mmhg within initi hms blood pressur mmhg increas mmhg within follow ephedrin administr patient recov anesthesia result support efficaci iv ephedrin treatment anesthesia associ hypotens pinnip | D004809;D007022 | T033;T121;T109 |
34,687,523 | efficaci human recombin granulocyt coloni stimul factor g csf filgrastim neupogen neutropen cetacean neutrophil one initi cell line protect pathogen concentr blood low anim high suscept infect neutropenia report cetacean secondari administr system sulfa antibiot antifung medic sever overwhelm infect filgrastim administ treat neutropenia period cetacean compris four speci beluga delphinapterus leuca n bottlenos dolphin tursiop truncatus n killer whale orcinus orca n short fin pilot whale globicephala macrorhynchus n rang age wk seven studi anim receiv multipl dose anim respond least one dose gkg parenter filgrastim character increas peripher immatur band neutrophil segment neutrophil case neutrophil count increas within h singl dose durat respons vari least wk eight anim remain anim advers reaction observ case | D016179;D009503 | T129;T047;T116 |
34,687,522 | outcom transplacent transmiss toxoplasma gondii chronic infect femal red ruf lemur varecia rubra ten red ruf lemur varecia rubra two adult femal eight offspr evalu case seri two adult femal diagnos chronic latent toxoplasmosi base serolog test first femal lemur two success pregnanc first pregnanc result transplacent transmiss toxoplasma gondii surviv offspr diagnos congenit toxoplasmosi base serolog test compat ophthalm lesion two deceas offspr dissemin nonsuppur inflamm intralesion protozo organ consist gondii confirm polymeras chain reaction second pregnanc result transplacent transmiss second chronic infect adult femal lemur one pregnanc result singl stillborn fetus without evid transplacent transmiss gondii treatment trimethoprim sulfamethoxazol folin acid administ first adult femal one offspr treatment given second adult femal surviv lemur complic associ toxoplasmosi case seri demonstr chronic latent infect reproduct femal red ruf lemur gondii may result variabl outcom transplacent transmiss dissemin fetal infect stillbirth transplacent transmiss congenit infect surviv lack transplacent transmiss healthi offspr inform gain case may help guid recommend breed critic endang speci | D007900;D007901;D014122 | T204;T015 |
34,687,521 | vitamin status indoor hous hoffmann two to sloth choloepus hoffmanni pilot studi disord calcium homeostasi report frequenc two to sloth yet littl investig perform vitamin miner metabol speci studi evalu biomark involv vitamin calcium metabol group nine manag hoffmann two to sloth choloepus hoffmanni correl diet analysi serum analyz vitamin metabolit miner calcium ca phosphorus p magnesium mg parathyroid hormon pth ioniz calcium ica diet analyz proxim nutrient miner vitamin feed intak estim averag valu report metabolit includ oh oh oh ngml pgml ngml respect averag pth pmoll averag ica mmoll valu report ca p mg within expect rang dietari concentr ngg averag daili intak per sloth iukg bodi weight detect level vitamin metabolit oh oh oh found diet serum data serv start point futur investig vitamin metabol calcium homeostasi two to sloth improv health manag set | D012896 | T015 |
34,687,520 | use symmetr dimethylarginin detect renal lesion fish preliminari studi brook trout salvelinus fontinali symmetr dimethylarginin sdma earli marker renal lesion mammal object studi establish refer interv sdma healthi brook trout salvelinus fontinali mitchil assess sensibl marker renal patholog plasma sdma quantifi liquid chromatographi mass spectrometri adult brook trout includ fish display renal histolog lesion five fish display chronic nonact microscop granuloma fish size p weight p statist differ among group sdma valu p howev brook trout without microscop renal lesion tend lower sdma valu lesion mean gdl lesion mean gdl refer interv confid interv ci sdma concentr brook trout rang gdl ci gdl ci valu higher previous report vertebr speci research need evalu use sdma marker renal function fish | D001120;D014337 | T116;T121;T109;T123;T013 |
34,687,519 | immobil mouflon ovi orientali musimon use medetomidin ketamin morphin dexmedetomidin ketamin morphin studi aim evalu efficaci two protocol immobil mouflon ovi orientali musimon six mouflon immobil twice use im medetomidin mgkg ketamin mgkg morphin mgkg mkm dexmedetomidin mgkg ketamin mgkg morphin mgkg dkm anesthet time record inject initi drug effect sternal recumb later recumb unrespons extern stimuli recoveri follow atipamezol im administr cardiopulmonari variabl hr beatsmin rr breathsmin mean systol diastol noninvas blood pressur map sap dap mm hg oxygen hemoglobin satur spo expir end tidal carbon dioxid p e co rectal temperatur c monitor record statist signific differ detect protocol time point signific differ detect measur variabl time point protocol howev signific decreas noninvas blood pressur variabl sap map dap rr detect time chemic immobil protocol provid least min immobil mouflon allow minor procedur tracheal intub | D020927;D007649 | T121;T109 |
34,687,518 | isofluran anesthesia budw pray mantis parasphendal agrionina pray mantis gain increas popular pet may anesthet allow morpholog identif clinic procedur aim studi evalu effect anesthet relat complic isofluran oxygen client own budw mantis parasphendal agrionina undergo photograph identif manti place self construct anesthet chamber expos mixtur approxim isofluran oxygen anesthet induct achiev time anesthet induct time recoveri anesthesia qualiti anesthesia base score right reflex front leg withdraw muscular tone evalu record well occurr undesir effect mantis immobl loss right reflex myorelax achiev within minut begin isofluran exposur last time suffici allow complet procedur howev mantis age mo longer time anesthet induct well shorter time recoveri mantis age mo p complic observ mantis return owner even | D000758;D000777;D018685;D007530;D020050 | T121;T109;T039;T204;T122;T061 |
34,687,517 | comparison tiletamin zolazepam combin dexmedetomidin xylazin chemic immobil wild fallow deer dama dama studi compar dexmedetomidin xylazin combin tiletamin zolazepam chemic immobil wild fallow deer dama dama prospect random blind clinic studi forti fallow deer divid two group tiletamin zolazepam xylazin tzx tiletamin zolazepam dexmedetomidin tzd tzx group immobil mgkg xylazin mgkg tiletamin zolazepam wherea tzd group immobil gkg dexmedetomidin mgkg tiletamin zolazepam dart induct time record immobil heart rate respiratori rate bodi temperatur hemoglobin oxygen satur blood lactat concentr qualiti immobil record drug administr time achiev sternal recumb stand also record tzd group show signific shorter induct time tzx group tzd group signific higher qualiti immobil score tzx group tzd group signific lower lactat level mmoll tzx group mmoll tzd group time sternal recumb tzx group tzd group time quadruped stand tzx group tzd group p dexmedetomidin combin tiletamin zolazepam viabl altern xylazin chemic immobil fallow deer | D020927;D013992 | T121;T109 |
34,687,516 | endoparasit synanthrop feral pigeon columba livia domestica southern ecuador parasit infect frequent cosmopolitan feral pigeon columba livia domestica live citi littl known effect parasit urban feral pigeon popul survey conduct evalu occurr endoparasit risk factor feral pigeon citi loja southern ecuador august octob total fecal sampl peripher blood smear collect examin mcmaster flotat method giemsa stain respect preval gastrointestin parasit parasit includ ascaridia columba capillaria sp eimeria sp unidentifi coccidia unidentifi nematod egg presenc intracellular gamont haemoproteus sp found examin blood smear frequenc intens nematod differ accord site haemoproteus infect frequent individu low bodi mass index research undertaken understand parasit infect effect cosmopolitan synanthrop feral pigeon | D001715;D007411;D009348 | T204;T047 |
34,687,515 | retrospect review ophidiomycosi ophidiomyc ophiodiicola smithsonian nation zoolog park retrospect review system local mycot infect captiv snake confirm via biopsi necropsi perform smithsonian nation zoolog park quantit polymeras chain reaction qpcr confirm infect ophidiomyc ophiodiicola oo n mycot infect infect oo even distribut period lack sex predilect period preval complet snake necropsi biopsi case oo posit speci affect includ green anaconda eunect murinus n garden tree boa corallus hortulanus n fals water cobra hydrodynast giga n yellow anaconda eunect notaeus n eastern milksnak lampropelti triangulum n brazilian rainbow boa epicr cenchria cenchria n eastern diamondback rattlesnak crotalus adamanteus n histopatholog demonstr one follow heterophil necrot epiderm without granulomat dermat n granulomat pneumonia n granulomat endophthalm n subcutan intramuscular fungal granuloma n studi document presenc ophidiomycosi captiv collect almost year despit current literatur design recent emerg pathogen | D017812;D009181;D020036 | T004;T047;T014 |
34,687,514 | influenc anesthesia without medetomidin cardiac structur function sanctuari captiv chimpanze pan troglodyt depend time assess anesthet agent specif medetomidin negat affect cardiac function great ape aim studi determin influenc tiletamin zolazepam tz without medetomidin cardiac structur function healthi chimpanze pan troglodyt period relat blood pressur stabil twenti four chimpanze live african wildlif sanctuari undergo routin health assess stratifi age sex bodi mass random anesthet use either tz mgkg n seven male six femal combin tz mgkg medetomidin tzm mgkg n five male six femal health check regular heart rate blood pressur read taken standard echocardiogram perform min induct data compar two anesthet group use independ sampl mann whitney u test although heart rate mean sd tz bpm tzm bpm p cardiac output tz lmin tzm lmin p mitral wave veloc tz cms tzm cms p lower tzm group statist signific differ cardiac structur remain function variabl group furthermor statist differ systol tz mmhg tzm mmhg p diastol blood pressur tz mmhg tzm mmhg p group echocardiogram studi shown period relat blood pressur stabil first min induct differ measur cardiac structur function protocol use tz without medetomidin healthi chimpanze | D000758;D000777 | T039;T121;T061 |
34,687,513 | comparison subcarapaci sinus brachial vein phlebotomi site blood collect free rang gopher tortois gopherus polyphemus pair blood sampl collect brachial vein subcarapaci sinus wild gopher tortois gopherus polyphemus comparison hematolog plasma biochem vitamin miner protein electrophoresi paramet general linear model repeat measur design comparison reveal higher brachial vein mean valu paramet signific p paramet signific lower brachial vein mean note two paramet coeffici variat brachial vein sampl lower paramet signific lower valu paramet paramet lower coeffici variat subcarapaci sinus sampl signific differ note four paramet lower coeffici variat higher mean valu paramet brachial vein sampl attribut greater hemodilut subcarpaci sampl lymph compar pair brachial vein sampl address clinic relev reliabl paramet rang obtain pair phlebotomi site compar valu obtain select investig gopher tortois desert tortois gopherus agassizii clinicopatholog although statist signific differ detect avail data demonstr mean standard deviat valu andor rang phlebotomi site studi similar report select studi base result util either set studi valu assess gopher tortois popul individu gopher tortois would accept clinic manag decis also advis investig develop institut blood paramet rang healthi individu phlebotomi site possibl addit maintain standard sampl collect handl protocol | D046348;D009174;D014426 | T015;T007;T014 |
34,687,512 | optim platelet rich plasma concentr protocol south american sea lion otaria flavescen acceler heal wild captiv south american sea lion otaria flavescen key tool help minim infect complic associ open wound dental diseas ocular patholog platelet rich plasma prp autogen sourc growth factor base platelet concentr obtain centrifug whole blood collect sodium citrat anticoagul current well defin prp concentr protocol human domest companion anim speci howev clear centrifug protocol obtain prp marin mammal speci studi aim optim platelet concentr protocol base whole blood centrifug use speed rang rpm time rang min blood drawn seven adult south american sea lion place ml sodium citrat tube centrifug follow differ centrifug protocol prp design lower third fraction centrifug plasma platelet count perform use flow cytometri statist analysi carri establish well defin protocol effici prp product transmiss electron microscopi tem analysi perform evalu possibl platelet degranul differ centrifug protocol measur platelet area maximum concentr platelet prp fold higher number platelet equal volum whole blood signific differ concentr obtain found centrifug protocol evalu use differ speed time combin best one step centrifug protocol result use rpm speed min highest fold increas achiev use two step centrifug protocol combin effici one step centrifug protocol rpm min second centrifug use rpm speed min tem analysi confirm platelet complet maintain integr propos protocol | D053657;D046070 | T015;T031 |
34,687,511 | optim fecal flotat marin parasitolog determin specif graviti helminth egg pinnip recent studi sought optim fecal flotat procedur improv detect helminth egg terrestri domest speci unclear howev whether effort optim applic parasit speci marin environ verif veterinari diagnost procedur clinic import hypothes egg belong parasit pinnip would differ specif graviti spg belong terrestri host fecal sampl collect strand pinnip repres three speci zalophus californianus phoca vitulina mirounga angustirostri modifi doubl centrifug flotat perform g sampl among california sea lion sampl trematod ascarid cestod egg detect individu respect sugar gradient modifi centrifug flotat conduct subset sampl california sea lion evalu distribut egg fraction repres vari spg higher number ascarid egg found fraction repres lower spg wherea trematod egg belong genus zalophotrema found signific higher number fraction repres p conclus spg trematod ascarid cestod egg pinnip appear similar terrestri host numer factor may affect abil detect use tradit diagnost approach explor natur variabl note may lead improv diagnost marin parasitolog | D010872;D006376;D046049;D046070 | T204;T015 |
34,687,510 | treatment mycobacteriosi caus mycobacterium avium ssp hominissui group captiv lowland tapir tapirus terrestri tapir taxonom group high suscept mycobacteri diseas howev success therapi document sporad treatment mycobacteriosi diagnos three one male two femal lowland tapir tapirus terrestri zoo germani report two anim show chronic mild respiratori sign convent therapi improv condit cultur broncho alveolar lavag bal sampl posit mycobacterium avium ssp hominissui upon airway endoscopi bronchial edema increas mucus product visibl initi three infect tapir receiv oral antimycobacteri therapi consist mgkg bodi weight isoniazid mgkg rifampicin mgkg clarithromycin qh base therapeut drug level monitor dose rifampicin adjust mgkg femal male respect treatment three drug continu mon six month treatment clinic condit resolv repeat bal sampl three tapir test negat mycobacteria cultur approach treatment protocol minim side effect suitabl control infect nontubercul mycobacteria lowland tapir report | D009161;D009164 | T007;T047 |
34,687,509 | perinat centrilobular hepat necrosi giant panda ailuropoda melanoleuca retrospect studi six giant panda cub ailuropoda melanoleuca born zoolog institut stillborn die age h two six cub panhepat centrilobular hepat necrosi chn granulocyt extramedullari hematopoiesi gem posit liver cultur staphylococcus speci termin liver failur anoth low weight cub administ oxygen therapi immedi birth develop hyalin membran air space hepat necrosi restrict hilar region retrospect analysi liver lung lesion pulmonari microanatomi blood gas barrier ultrastructur hepat myofibroblast prolifer conduct six cub neonat chn concurr sever periport gem accompani sever myofibroblast prolifer pulmonari blood gas barrier mark increas one cub chn development lung one cub late saccular stage lowest weight cub earli saccular stage consist immatur pneumonia compar neonat respiratori distress syndrom rds stage lung develop elimin primari factor lead chn pathogenesi chn neonat propos transform hepat stellat cell myofibroblast initi blockag microvascular constrict hepat sinusoid result insuffici perfus cellular hypoxia hepatocyt surround central vein acinar zone | D001503 | T015 |
34,687,508 | retrospect studi brain lesion captiv nondomest felid retrospect studi identifi character brain lesion captiv nondomest felid larg cat sanctuari necropsi report januari decemb examin gross imag microscop slide review individu cat avail total cat met follow inclus criteria complet necropsi report avail brain examin grossli microscop age mon cat cat determin brain lesion eleven differ felid speci well one captiv bred hybrid liger includ studi tiger panthera tigri lion panthera leo common speci lesion group six etiolog categori neoplast vascular inflammatori infecti congenit idiopath metabol includ categor lesion previous undescrib amphophil globul cerebr cortex mani cat without brain lesion lion tiger brain cerebr cortex avail histolog examin globul associ clinic diseas histopatholog gross brain chang document studi provid insight specif diseas patholog process affect brain captiv larg cat popul | D045989;D008045;D046010 | T015 |
34,687,507 | review mortal tentacl snake erpeton tentaculatum multi institut zoolog collect tentacl snake erpeton tentaculatum vivipar aquat snake desir speci exhibit zoolog collect uniqu appear feed strategi despit presenc zoo collect past yr comprehens review mortal morbid speci publish studi retrospect review patholog report tentacl snake multi institut zoolog collect new york wildlif conserv societi bronx central park zoo half death due infecti diseas n half n due fungal dermat fungal histomorpholog consist paranannizziopsi spp case death due bacteri infect also relat common n one third intralesion bacilli consist mycobacterium spp n common comorbid includ gastrointestin parasit n renal patholog n lipid accumul hepatocyt n retrospect review suggest manag infecti diseas play role long term care surviv captiv tentacl snake | D017812;D003881;D020036 | T004;T047;T014 |
34,687,506 | review histolog lesion mortal rio cauca caecilian typhlonect natan year period rio cauca caecilian typhlonect natan uniqu fulli aquat speci amphibian order gymnophiona hous sever zoolog institut aquaria limit inform avail regard health diseas retrospect studi evalu common patholog find caus mortal rio cauca caecilian three differ institut period comparison previous medic health survey conduct evalu accord age class sex determin whether primari caus mortal common histolog find remain similar time institut mortal includ male femal undetermin sex major examin individu adult follow juvenil neonat undetermin age class thirteen individu euthanat adult femal repres largest group adult common lesion contributor death renal diseas follow skin diseas includ oomycet dermat saprolegnia sp common find includ bacteri dermat gastrointestin nematodiasi adren hyperplasia retrospect studi provid use refer help guid veterinari care manag decis collect manag plan caecilian speci manag care | D000663 | T011 |
34,687,505 | use tricain methanesulfon clove oil phenoxyethanol immers euthanasia unga cichlid sarotherodon linellii fish may warrant euthanasia varieti reason euthanasia may difficult accomplish confirm fish recov deep anesthesia even cardiac respiratori arrest efficaci three type anesthet evalu compar suitabl euthanasia unga cichlid sarotherodon linellii thirti cichlid random assign immers one three anesthet solut tricain methanesulfon ms phenoxyethanol pe clove oil co dose mgl mll mgl respect opercular rate caudal fin stroke rate quantifi time cessat physiolog measur cpm includ caudal fin stroke reaction extern stimuli right reflex swim opercul record vari anesthet induct time observ three euthanasia solut time cpm pe group occur signific slower rate ms group p cost euthanasia per cichlid calcul econom viabl option pe seven time price pe ms expens min immers euthanasia solut presenc audibl heartbeat identifi cichlid immers pe immers co ms indic reliabl euthan therefor two step protocol recommend cichlid euthanasia heavi anesthesia via immers follow intraven intracardiac inject euthanasia solut secondari method euthanasia | D000777;D023681 | T039;T121;T013 |
34,687,504 | biomark gastrointestin diseas cheetah acinonyx jubatus gastrointestin diseas common clinic problem captiv cheetah acinonyx jubatus report gastriti affect vast major captiv popul cheetah pancreat acut chronic enter also report issu pose signific long term health welfar implic cheetah cobalamin folat methylmalon acid mma gastrin felin pancreat specif lipas immunoreact fpli felin trypsin like immunoreact ftli immunoassay import biomark gastrointestin diseas domest cat goal studi determin immunoassay valid domest cat could use clinic cheetah establish refer interv ri biomark cheetah cohort clinic healthi cheetah select three zoolog institut basi free clinic gastrointestin diseas extra gastrointestin diseas could affect biomark well bank frozen serum cheetah biomark ri domest cat ri comparison parenthes follow cobalamin pgml pgml folat ngml ngml mma nml nml fpli gl gl gastrin pgml pgml studi show ri gastrointestin biomark notabl differ even speci close relat domest cat cheetah addit found ftli assay cross immunoreact cheetah conclus studi emphas import develop speci specif ri biomark assay use caution extrapol ri speci | D002612;D002371;D005756 | T015;T047 |
34,687,503 | evalu pharmacokinet behavior tulathromycin draxxin florida manate trichechus manatus latirostri undergo medic rehabilit florida manate trichechus manatus latirostri frequent present rehabilit care facil various condit includ boat strike trauma cold stress syndrom brevetoxicosi throughout cours treatment antimicrobi use treat respiratori diseas frequent warrant date clinician extrapol dosag base establish inform avail bovin equin medicin rout administr efficaci treatment interv consider deal critic wild anim use tulathromycin triamilid antibiot studi multipl domest speci econom import includ cattl small rumin swine reveal efficaci respiratori diseas given inform antibiot also use manate posit clinic outcom studi employ spars sampl evalu bank plasma sampl various time interv post tulathromycin administr obtain clinic treatment cours nine anim rehabilit preliminari pharmacokinet analysi follow administr singl dose estim half life h volum distribut per fraction absorb vzf lkg pharmacokinet behavior tulathromycin florida manate use optim dosag regimen speci | D020457 | T015 |
34,687,502 | pharmacokinet subcutan alpha lipoic acid propos therapeut aid domoic acid intox california sea lion zalophus californianus domoic acid da potent neurotoxin produc certain marin alga caus neurolog cardiac dysfunct activ glutam receptor glutam receptor overexcit result continu cellular activ oxid damag cell death da toxicosi caus disorient seizur antiseizur medic primari treatment alpha lipoic acid ala power antioxid glutathion precursor wide use human dog cross blood brain barrier provid antioxid avail brain tissu hundr strand california sea lion csl zalophus californianus diagnos annual da toxicosi thus appropri anim establish ala dose recommend treatment object studi determin popul pharmacokinet singl mgkg dose ala administ subcutan interscapular region healthi rehabilit csl blood collect two time point min h administr serum ala concentr measur liquid chromatographi mass spectrometri paramet evalu use nonlinear mix effect model ala rapid absorb dose peak within minut min mgkg respect follow initi steep distribut phase prolong elimin phase peak concentr c max ngml mgml dose ngml mgml dose serum csld da toxicosi treat mgkg ala measur level ala also measur cerebrospin fluid two treat csls therapeut effect note c max ngml human thus csls mgkg administ subcutan daili may suffici achiev therapeut level speci determin efficaci optim dose interv durat requir addit investig | D046070;D008063 | T015;T127;T121;T109 |
34,687,501 | preval antimicrobi resist pattern salmonella spp two free rang popul eastern box turtl terrapen carolina carolina salmonellosi import zoonot infect exposur pet reptil implic sever human outbreak although sever studi report low preval salmonella free rang chelonian may serv reservoir spring summer free rang eastern box turtl terrapen carolina carolina popul illinoi rural tennesse urban collect canin visual search cloacal swab sampl collect turtl select enrich tetrathion broth plate select differenti media isol salmonella spp genus confirm via maldi tof ms antibiot sensit perform isol serotyp nation veterinari servic laboratori turtl sampl salmonella spp detect nine individu ci isol includ five differ serovar anatum n newport n thompson n bareilli n hartford n salmonella spp detect six anim ci three ci signific differ preval state p illinoi locat p season p year p sex p age class p health salmonella posit negat turtl signific differ assess hematolog plasma biochemistri p indic asymptomat carrier status low preval detect studi like conclud free rang eastern box turtl play minim role spread salmonella howev identifi serotyp potenti human anim pathogen document preval salmonella serotyp anim indic further understand spread human anim agricultur environ | D014426 | T014 |
34,687,499 | endoparasitoid use egg surfac protein regul host immun respons proteom analysi identifi egg surfac protein endoparasitoid cotesia chiloni protein contain conserv enzymat domain constitut larg proport egg surfac compon protein superoxidas dismutas homolog c rubecula kda protein immunoevas protein classic parasit factor known function host immun regul melan assay reveal novel egg surfac protein c chiloni egg surfac serpin domain contain protein function c chiloni venom serpin suppress host melan dose depend manner c chiloni egg surfac serpin domain contain protein main transcrib c chiloni oocyt follicular cell locat anterior posterior side matur egg surfac addit use lc msms identifi bind protein sourc c suppressali plasma locat eggshel surfac c chiloni includ immun relat protein result indic c chiloni use egg surfac protein reduc immun respons host also impli endoparasitoid egg surfac protein might new parasit factor involv host immun regul | D015843;D014863 | T204;T116;T121;T123 |
34,687,497 | long last implic embryon exposur alcohol insight zebrafish research harm consumpt ethanol associ signific health problem social burden drug activ complex network reward mechan habit format learn suppos contribut consumpt increas high frequent amount ultim lead addict context fetal alcohol spectrum disord fetal alcohol syndrom fas consequ harm use alcohol pregnanc affect embryon develop fetus fas easili reproduc zebrafish expos embryo differ concentr ethanol water regard aim present review discuss late patholog implic zebrafish expos ethanol embryon stage provid inform context human fetal alcohol spectrum disord experiment fas zebrafish associ impair metabol morpholog neurochem behavior cognit domain mani pathway affect ethanol zebrafish least one ortholog human collabor wider adopt zebrafish studi alcohol disord fact zebrafish present valid requir studi condit contribut use speci research addit studi rodent | D063647;D015027 | T013;T047;T019 |
34,687,495 | develop evalu multiplex qpcr assay rapid diagnost emerg sporotrichosi sporothrix schenckii relat speci agent human anim sporotrichosi routin diagnos use classic mycolog approach unspecif due overlap phenotyp frequenc preval sporotrichosi increas worldwid develop specif sensit cost effect diagnost tool essenti understand distribut pattern map affect area promot specif public health strategi mitig futur outbreak polymorph among tubulin gene exploit speciat brasiliensi schenckii globosa one tube multiplex probe base qpcr assay panel sporothrix reveal specif auc ci p without cross react medic relev fungi human felin murin dna speciat via multiplex qpcr match phylogenet identif kappa ci good agreement support use reliabl altern dna sequenc remark lower limit detect copi target speci proof concept use swab wound exud cat suspect sporotrichosi reveal overwhelm occurr brasiliensi specimen sensit ci specif ci comparison cultur qpcr show larger area curv auc ci p youden index support qpcr essenti tool accur detect sporothrix dna direct clinic sampl thus acceler diagnosi sporotrichosi moreov multiplex qpcr system potenti increas diagnost capac sporothrix affect area help local anim health agent veterinarian quick identifi isol new case like benefit thousand patient infect everi year worldwid | D002371;D013175;D013174 | T004;T047 |
34,687,494 | gastrointestin transit contractil diabet constip wireless motil capsul studi diabet patient healthi control diabet constip tradit attribut slow colon transit despit limit evid half patient find treatment unsatisfactori improv treatment need better diagnost understand condit | D053704 | T060 |
34,687,493 | sar cov superinfect reinfect three differ strain report corona virus diseas covid case unpreced viral complex first sever episod two differ sever acut respiratori syndrom coronavirus sar cov strain superinfect identifi within week three month discharg patient readmit infect nosocomi outbreak differ strain suffer second milder covid episod | D000086382;D015163 | T047;T067 |
34,687,490 | right medial tempor lobe structur particular impact earli stage affect pictur process human vision priorit emot stimuli reflect stronger electrocort activ respons emot neutral stimuli measur surfac head feedback project brain structur deep within medial tempor lobe mtls particular amygdala thought give rise phenomenon although causal evid rare given mani pathway involv visual process influenc mtl structur could restrict specif time window therefor delin tempor dynam impact right mtl structur affect pictur process investig event relat potenti erp patient femal right mtl resect individu match healthi particip view negat neutral scene group differ signific earli mid latenc process stage patient right mtl resect unlik control show p ms margin n ms emot modul mid latenc earli posterior negat ms emot modul ipsi resect right hemispher smaller patient control group differ left hemispher late pariet posit ms ms group similar emot modul result demonstr right mtl structur attenu particular earli process affect negat scene theoret consist initi amygdala depend feedforward sweep visual emot process whose absenc success compens find specifi impact right mtl structur emot pictur process highlight valu time resolv measur affect neurosci | D001931;D004569 | T062;T034;T060 |
34,687,489 | preval sever addict gabamimet drug elder german general hospit popul focus gabapentinoid benzodiazepin z hypnot drug gabapentinoid gpt report increas misus opioid polydrug user addict potenti gpt outsid popul remain understudi investig compar gpt abus depend liabil common prescrib central nervous system act medic therefor warrant provid comparison gpt abusedepend gabamimet within elder popul | D001569;D009293 | T048;T121;T109 |
34,687,488 | clinicopatholog featur resist mechan hip alk rearrang lung cancer multicent studi anaplast lymphoma kinas alk rearrang non small cell lung cancer nsclc respond well alk tyrosin kinas inhibitor tkis echinoderm microtubul associ protein like eml alk rearrang nsclc account major patient howev studi evalu alk tkis treatment patient huntingtin interact protein hip alk fusion retrospect studi evalu clinicopatholog characterist genom featur respons alk tkis resist mechan case hip alk fusion five chines center patient receiv crizotinib chines center object respons rate case confid index ci median progress free surviv month ci na month median overal surviv month ci na month one patient receiv first line lorlatinib treatment achiev partial respons month despit small sampl size hip alk h variant common variant four case associ better outcom among case eight patient avail specimen genet test alk tkis treatment four patient undergo biopsi alk tkis failur common coexist gene tp among patient two four patient crizotinib failur harbor acquir alk mutat eg lvqk lm brigatinib treatment appear effect patient fail crizotinib treatment lvqk mutat might relat increas bind affin mutant although hip alk rearrang nsclc appear initi respond well alk tkis crizotinib resist may correl akap braf fusion alk compound mutat lvqk alk lm mutat larger studi need evalu signific hip alk rearrang nsclc | D019008;D015321 | T042;T038;T045 |
34,687,487 | monomer c reactiv protein via endotheli cd neurovascular inflamm apo genotyp depend pattern risk factor alzheim diseas chronic peripher inflamm endothelia brain capillari bed could play role apolipoprotein e apo mediat risk alzheim diseas ad risk use human brain tissu demonstr interact endotheli cd monomer c reactiv protein mcrp versus apo link shorten neurovasculatur ad patholog cognit use apo knock mice discov intraperiton inject mcrp via bind cd endotheli surfac increas cd phosphoryl pcd lead cerebrovascular damag extravas lymphocyt apo brain mcrp bound endotheli cd dose time depend manner knockdown cd signific decreas mcrp bind alter express vascular inflammatori factor includ vwf nf b p eno rnaseq reveal endotheli pathway relat oxid phosphoryl ad pathogenesi enhanc endotheli pathway involv epigenet vasculogenesi inhibit apo first report provid evid apo mcrp cd pathway cross talk peripher inflamm cerebrovasculatur lead ad risk | D005838 | T032 |
34,687,486 | shareabl antibacteri osteoblast prolifer activ zinc dope hydroxyapatit nanoparticl vitro four type zinc zn dope hydroxyapatit zn hap nanoparticl prepar use calcium nitrat tetrahydr anti sinter agent calcin c hr prevent calcin induc aggreg zn content nanopowd determin zn ca zn use induct coupl plasma atom emiss spectroscop analysi base x ray diffract analysi product shown possess apatit structur without crystallin impur cell paramet zn hap nanoparticl decreas increas zn content hap structur tendenc impli zn ion substitut ca site hap crystal lattic investig biolog effect zn hap nanoparticl cell prolifer activ mct e osteoblast antibacteri activ escherichia coli evalu vitro accord result obtain zn hap nanoparticl contain zn ion notic shown shareabl conflict activ mgml | D017886;D053758 | T073;T121;T122;T197 |
34,687,485 | updat review prognost factor mycosi fungoid new skin lymphoma trial ten year surviv rate mycosi fungoid mf broad vari howev standard prognost index avail presum due low preval heterogen diagnost challeng mf recent studi focus identifi object prognost indic use differ paramet surviv determin cutan lymphoma intern prognost index clipi prospect cutan lymphoma intern prognost index proclipi repres prototyp studi identifi prognost factor seek improv manag outcom earli stage mf detect factor stratifi mf patient accord diseas progress risk may help manag patient effici | D009182;D012878 | T191 |
34,687,484 | chang stabl chromatin access support transcript overhaul neural stem cell activ alter age neural stem cell nscs adult age brain larg quiescent requir transcript reprogram enter cell cycl howev mechan under chang alter age remain undefin identifi chromatin access differ primari neural stemprogenitor cell quiescent activ state distinct cellular state exhibit share uniqu chromatin profil associ gene regul access chromatin state specif activ quiescenc activ enhanc bound key pro neurogen quiescenc factor contrast share site enrich core promot element associ translat metabol unexpect integr analysi find mani site becom access nsc activ link gene repress associ pro quiescenc factor reveal novel mechan may preserv quiescenc entri furthermor report age nscs chromatin region associ metabol transcript function bound key pro quiescenc transcript factor lose access suggest novel mechan age associ nsc dysfunct togeth find reveal access chromatin state regul transcript switch nsc quiescenc activ switch affect age | D015533 | T045 |
34,687,483 | effect differ concentr chlorhexidin microbi colon doubl blind random control studi studi aim determin effect chlorhexidin concentr use reduc microbi colon patient mechan ventil examin effect oral care use differ concentr integr oral mucous membran | D002710;D012121 | T061;T121;T109 |
34,687,482 | inhibit fucoidan breast cancer cell potenti enhanc sensit chemotherapi regul autophagi fucoidan marin origin sulfat polysaccharid gain attent anticanc activ howev inhibitori effect fucoidan breast cancer regul autophagi mechan clear chemotherapeut sensit fucoidan larg unknown present studi anticanc potenti fucoidan reveal mcf mda mb cell addit also studi chemotherapeut sensit fucoidan combin chemotherapeut drug doxorubicin adm cisplatin ddp fucoidan breast cancer cell two kind human breast cancer cell cell viabil determin dimethyl thiazolyl diphenyl h tetrazolium bromid mtt assay apoptosi examin flow cytometri transfect assay use examin autophagi flow western blot use examin express relat protein result suggest fucoidan could induc autophagi might enhanc sensit breast cancer cell chemotherapeut drug mechanist fucoidan induc autophagi breast cancer cell regul torpsktfeb pathway conclus research reveal fucoidan could induc autophagi breast cancer cell mediat torpsktfeb pathway thus inhibit tumor develop furthermor fucoidan might enhanc sensit breast cancer cell adm ddp enhanc relat autophagi | D000970;D001943 | T191;T121;T109 |
34,687,480 | surgic techniqu long term outcom pediatr live donor domino liver transplant patient mapl syrup urin diseas nativ liver patient mapl syrup urin diseas msud st recipi use graft non msud patient end stage liver diseas nd recipi studi aim demonstr optim oper procedur long term outcom nd recipi | D019520 | T098 |
34,687,477 | barrier enabl face region rural school support student mental health mix method systemat review australian polici report recommend school leverag better support student mental health focus region rural area student poorer mental health outcom design solut address system gap decis maker requir understand barrier facilit experienc region rural school howev current literatur focus metropolitan school neglect explor facilit | D008603;D012574 | T092;T073;T041 |
34,687,476 | heart failur recov eject fraction hfrecef new entiti improv cardiac outcom aim studi better character heart failur hf recov eject fraction hfrecef undul ef hfuef regard hospit due congest hf chf adequ electr therapi aet mortal compar hf reduc ef hfref mid rang ef hfmref preserv ef pef | D017147;D013318 | T034;T033;T074;T201 |
34,687,474 | social affili moder link depress symptom heart rate variabl healthi middl age older individu intens ecolog momentari assess studi depress symptom associ lower cardiac autonom control thus contribut cardiovascular diseas especi among older adult interperson factor found attenu physiolog stress respons littl known whether factor eg perceiv affili would moder relat depress symptom cardiovascular activ present research aim investig interplay depress symptom momentari assess interperson percept cardiac vagal tone index heart rate variabl hrv sampl consist late middl age older communiti dwell particip male mean age year particip report depress symptom person characterist questionnair percept interperson affili ambulatori hrv contextu variabl record use ecolog momentari assess portabl electrocardiogram ecg monitor devic throughout week maximum seven time daili multilevel analys found depress symptom correl lower hrv wherea momentari interperson percept higher affili associ elev hrv signific associ reveal depress symptom momentari affili percept hrv individu involv social interact higher affili effect depress symptom reduc hrv attenu find suggest effect subthreshold depress symptom vagal control heart could alter qualiti interperson experi | D000072860;D000083505 | T033;T054;T060 |
34,687,472 | phenotyp genotyp parallel evolut parapatr ecotyp senecio independ repeat adapt popul similar environ often result evolut similar form phenomenon creat strong correl phenotyp environ refer parallel evolut howev still larg unawar dynam parallel evolut well interplay phenotyp genotyp within natur system examin phenotyp genotyp parallel evolut multipl parapatr dune headland coastal ecotyp australian wildflow senecio lautus observ clear trait environ associ system replic popul evolv along phenotyp evolutionari trajectori similar phenotyp arisen via mutat chang occur differ gene although mani share biolog function result shed light replic adapt manifest phenotyp genotyp level within popul highlight lautus one strike case phenotyp parallel evolut natur | D012674 | T002 |
34,687,471 | role abscis acid modul drought acclim agronom characterist n oxalyl l diaminopropion acid odap accumul grass pea lathyrus sativus l n oxalyl l diaminopropion acid odap physiolog indic respons dri soil howev abscis acid aba modul odap accumul relat agronom characterist drought stress grass pea lathyrus sativus l continu unclear present studi aim evalu effect aba addit drought toler agronom characterist odap content grass pea drought stress | D027807 | T002 |
34,687,470 | link justic sensit moral reason moral emot moral ident middl childhood associ moral relat trait justic sensit js tendenc negat respond injustic moral develop larg unknown may decemb year old sd girl transgend gender nonconform germani rate js moral reason emot ident parent teacher rate children theori mind tom empathi victim js care justic predict attribut posit emot norm transgressor structur equat model altruist js care justic predict less attribut posit emot stronger moral ident unless tom consid particular altruist js show associ advanc moral develop henc moral relat trait deserv attent moral develop research | D009014;D012935 | T080;T078 |
34,687,469 | predict maxim costal cartilag graft size laryngotrach reconstruct current method assess rib cartilag dimens laryngotrach reconstruct ltr inexact make surgic plan difficult purpos studi determin appropri rib costal cartilag graft ltr minim number rib harvest improv surgic outcom | D066186 | T024 |
34,687,468 | locoregion recurr skin spare nippl spare mastectomi skin nippl spare mastectomi ssmsnsms present altern patient requir mastectomi better aesthet result aim evalu locoregion recurr lrr rate predict factor | D015413;D015414 | T061 |
34,687,465 | novel adenoidectomi train system young resid find mirror guid adenoidectomi difficult inexperienc traine must learn focus headlight beam work upsid backward small space thorough ablat adenoid tissu new skill present adenoidectomi train system low cost easi construct focus basic adenoidectomi skill | D000234;D013337 | T097;T023 |
34,687,464 | lactat pyruv level correl lactat dehydrogenas gene express glucos consumpt tamoxifen resist mcf cell use capillari electrophoresi contactless conduct detect ce c breast cancer second lead caus cancer death women lung cancer first line treatment metastat breast cancer premenopaus women reli tamoxifen develop tamoxifen resist fulli understood studi capillari electrophoresi capacit coupl contactless conduct detector develop monitor chang lactat pyruv level supernat media three model develop mcf tamoxifen resist cell correl metabolit chang lactat dehydrogenas gene express glucos consumpt electrophoret separ achiev revers electroosmot flow condit linear rang mm correl coeffici limit detect lactat pyruv respect inter intrarun accuraci rang precis cv method complet valid result agreement obtain use lactat glucos assay kit result reveal signific increas lactat pyruv product three tamoxifen resist mcf cell model compar control cell increas correl increas lactat dehydrogenas gene express increas glucos consumpt | D001943;D019289 | T191;T121;T109;T123 |
34,687,463 | dramat effect black soldier fli larva fungal communiti compost black soldier fli larva bsfl offer good prospect product cheap high qualiti dietari protein insect abl consum low qualiti substrat includ food wast properti safeti compost obtain larg determin microbiom howev bacteri compon bsfl compost microbiom much studi littl known fungal compon plant base rear substrat biomass metabol activ fungi often exceed biomass activ prokaryot purpos studi investig fungal communiti compost produc bsf larva rear food wast substrat | D000076282;D004175;D000072761;D012037 | T057;T167;T004;T204;T068 |
34,687,461 | earli erp function index later effect peripher present emot face scrambl larg bodi research suggest earli event relat potenti erp p n potenti attent repres stimulus amplif howev recent account suggest p associ inhibit irrelev visual field evidenc pronounc ipsilater p sustain attent peripher present stimuli current eeg studi investig issu reveal later erp find modul face emot inform therefor particip ask fixat center screen pay sustain attent either right left visual field angri neutral face fourier phase scrambl version present found bilater p stimuli relat increas delay ipsilater p amplitud face scrambl explor independ compon analys dissoci earlier later larger contralater p later bilater p contrast n show contralater enhanc stimuli pronounc neutral face attend left hemifield final increas contralater alpha power found attend hemifield signific relat poststimulus erp result provid evid general inhibitori role p suggest stimulus specif relat enhanc ipsilater p irrelev visual hemifield later n howev associ stimulus amplif function facial featur | D005149 | T033 |
34,687,459 | basal forebrain magnocellular cholinerg system damag mice follow neonat hypoxia ischemia neonat hypox ischem encephalopathi hie caus lifelong neurolog disabl despit use therapeut hypothermia memori deficit execut function remain sever affect cholinerg neurotransmiss basal forebrain neocortex hippocampus central higher cortic function examin basal forebrain light microscopi report loss cholin acetyltransferas posit chat neuron postnat day p ipsilater medial septal nucleus msn neonat hypoxia ischemia hi mice loss chat neuron ipsilater nucleus basali meynert nbm striatum ipsilater striatal nbm chat neuron abnorm alter immunoreact chat shrunken crenat soma dysmorph appear dendrit use confoc imag reconstruct nbm chat dendrit hi mice shorter sham p loss chat neuron msn direct correl loss ipsilater hippocamp area nbm striatum percentag abnorm chat neuron correl loss ipsilater cerebr cortic striatal area respect acetylcholinesteras ach activ increas adjac ipsilater cerebr cortex hippocampus increas linear relat loss cortic hippocamp area number size cathepsin lysosom increas larg neuron ipsilater nbm neonat hi abnorm found throughout major cholinerg system relationship amount forebrain area loss also upregul cathepsin particl within nbm cholinerg neuropatholog may underli perman dysfunct learn memori execut function neonat brain injuri | D066187 | T023 |
34,687,458 | identifi patient center outcom measur compar effect treatment trial myasthenia gravi data regard compar effect myasthenia gravi mg treatment avail use patient input identifi patient center outcom measur pcom promis mg compar effect trial mg treatment | D009157;D011788 | T047;T078 |
34,687,457 | loss function arabidopsi f box protein hypersensit aba enhanc drought toler delay germin aba phytohormon involv divers plant event seed germin drought respons f box protein function substrat receptor scf complex respons ubiquitin target protein trigger subsequ degrad mediat ubiquitin proteasom system isol gene name arabidopsi f box protein hypersensit aba afa upregul aba afa interact adaptor protein scf complex impli role substrat receptor complex loss function mutant afa seedl exhibit aba hypersensit includ delay germin presenc aba moreov loss afa led increas drought toler adult plant microarray data aba treatment indic gene upregul downregul respect three time afa relat wild type among upregul gene afa express induc three time presenc aba repress extent data indic afa involv downregul mani aba induc gene accord aba hypersensit phenotyp afa epistasi analysi show afa could play role upstream abi abi aba signal germin inhibit collect find suggest afa novel f box protein negat regul aba signal | D017360;D029681;D044783 | T116;T002 |
34,687,456 | chronic lymphocyt thyroid aggress pediatr differenti thyroid cancer hashimoto thyroid ht common caus hypothyroid among adult differenti thyroid cancer dtc ht appear associ less sever diseas burden absenc inform regard ht diseas burden among children dtc assess relationship pediatr dtc sever ht | D000230;D050031;D013964 | T191;T047 |
34,687,455 | effect low temperatur microwav treatment wheat germ wheat germ great potenti byproduct food formul outstand nutrit valu allow valor need inactiv endogen enzym lipas avoid lipid oxid present studi effect microwav enzym activ well function physic properti wheat germ evalu microwav treatment perform c min | D008872;D014908 | T070;T002;T057;T168 |
34,687,453 | proteom analysi reveal digest resist protein colostrum associ inflammatori cytotox respons intestin epitheli cell although human milk feed reduc risk necrot enterocol nec preterm infant compar formula feed exact risk reduct mechan remain unknown nec occur distal small intestin digest occur appli proteom examin extent colostrum protein surviv simul infant vitro digest thus potenti exert biolog function | D003126;D020345 | T047;T031 |
34,687,452 | compar studi physicochem micellar solubil perform monoglucosyl rebaudiosid rebaudiosid rebaudiosid ra monoglucosyl deriv like rebaudiosid rd popular stevia glycosid possess poor solubl water limit applic edibl surfact applic micellar solubil drug deliveri meanwhil effect monoglucosyl attach ra moieti remain unclear | D045786;D036625 | T002;T109 |
34,687,451 | fisher inform function score binari ideal point item respons model cautionari tale articl examin fisher inform function explor implic score binari ideal point item respons model model typic appear bimod ident equal ideal point articl show inher properti ideal point irt model either properti indetermin thus violat likelihood regular condit model indeterminaci resolv generat effect unimod albeit violat regular condit case diverg reason ideal point irt model exhibit behaviour user exercis caution reli asymptot particular shorter assess use simul plausibl valu predict fulli bayesian estim recommend score | D011594 | T060 |
34,687,450 | hard becom mother moral economi postpon motherhood neoliber chile delay childbear one promin transform contemporari fertil reproduct pattern articl provid novel approach understand women postpon motherhood children later life draw life stori interview women santiago de chile argu transit motherhood shape moral economi women postpon childbear enabl becom good mother context social fertil redefin neoliber intens mother lone motherhood find women delay childbear achiev profession financi mileston allow fulfil normat condit children find suggest women postpon transit motherhood reject childbear tradit gender role rather aspir becom good mother context character institut precari relat insecur increas demand mother find challeng preval interpret women children later life extend account gender norm social fertil contest natur autonomi drive chang women live | D009014;D009035 | T092;T099;T078 |
34,687,448 | social charact interdepend dualiti directed david riesman explor direct characterolog form suit corpor capit rise servic sector becam one influenti sociolog analys twentieth centuri yet sociologist interest contemporari fate disposit qualiti suit mutual adjust confront paradox age increas interdepend appar conduc susten directed wit rise concern resurg social sectarian account tension reli upon structuralist explan late modern disrupt impact psychologist account group allegi contrast develop meso level analysi highlight increas consequenti dualiti heart directed qualiti associ characterolog form still facilit select form mutual demand place upon peopl current era also prompt grow level resent antagon | D010551;D012961 | T090;T054;T041 |
34,687,446 | long term safeti toler fremanezumab migrain prevent treatment japanes outpati multicent random open label studi earli discontinu poor adher common limit convent prevent migrain medic limit long term efficaci therefor migrain prevent medic favor long term safeti warrant | D008881;D010045 | T047;T101 |
34,687,445 | review post treatment lyme diseas syndrom chronic lyme diseas practic immunologist lyme diseas infect caus borrelia burgdorferi sensu lato transmit human bite infect ixod tick major patient recov without complic antibiot therapi howev minor patient accompani non specif symptom persist month follow complet therapi constel symptom fatigu cognit dysfunct musculoskelet pain persist beyond month associ disabl term post treatment lyme diseas syndrom ptlds subset broader term chronic lyme diseas chronic lyme diseas broad vagu defin term use describ patient non specif symptom attribut presum persist borrelia burgdorferi infect patient may may evid either previous current lyme diseas diagnos chronic lyme diseas ptlds becom increas relev practic immunologist due referr consult intraven immunoglobulin ivig treatment review aim explor relationship chronic lyme diseas post treatment lyme diseas syndrom immun system review current literatur issu convent altern diagnost test lyme diseas hypothesi b burgdorferi infect persist despit appropri use recommend antibiot current theori regard b burgdorferi role caus immun dysregul protract symptom use ivig treatment lyme diseas | D025065;D018884;D008193;D000077342 | T204;T007;T047 |
34,687,444 | mortal hereditari angioedema worldwid review real world data literatur studi aim review global mortal secondari laryng edema patient diagnos hereditari angioedema relat year well describ epidemiolog clinic find associ outcom extens search literatur made pubm scopus embas identifi mortal rate secondari laryng edema patient hereditari angioedema search carri septemb april keyword base mesh term search three databas filter languag use find articl english limit year public total twenti three articl fulfil inclus criteria review data extract analyz studi includ patient death asphyxia due laryng edema one hundr three death close relat describ secondari caus main find summar tabl year place public number patient death laryng edema patient previous diagnos death age death rate laryng edema averag one death everi patient eight studi report death relat everi patient studi one relat die percentag among death general associ laryng edema evalu three studi high frequenc outcom suggest death still occur improv hereditari angioedema treatment still need met | D054179;D007819 | T047;T046 |
34,687,443 | sirt regul neuron excit alzheim diseas model oxid stress depend manner mitochondri deacetylas sirtuin sirt shown regul metabol antioxid function previous studi report sirt mediat chang neuron excit howev under mechan unclear show sirt defici result neural hyperact decreas surviv rate increas oxid stress cultur neuron superoxid dismutas mimet reduc oxid stress suppress neuron hyperact cultur neuron treat sirt activ reduc level reactiv oxygen speci ros hyperact neuron increas level ros restor neuron hyperact util two photon vivo brain imag show inhibit sirt result elev neuron excitatori anim model alzheim diseas earli stage wherea suppress ros level revers find demonstr oxid stress depend role sirt regul neuron excit alzheim diseas | D000544;D056566 | T048;T047;T116;T126 |
34,687,440 | pharmacolog diosmin citrus flavon glycosid updat review flavonoid phytochem well known benefici pharmacolog properti diosmin flavon glycosid deriv hesperidin flavanon abund found citrus fruit daflon oral phleboton flavonoid combin contain diosmin hesperidin common use manag blood vessel disord oral administr diosmin convert diosmetin subsequ absorb esterifi glucuronid conjug excret urin pharmacolog effect diosmin investig sever vitro vivo studi found possess anti inflammatori antioxid antidiabet antihyperlipidem antifibrot effect differ diseas model diosmin also demonstr multipl desir properti sever clinic studi moreov toxicolog studi show diosmin favor safeti profil accord diosmin potenti effect safe treatment mani diseas howev diosmin exhibit inhibitori effect differ metabol enzym encourag investig potenti therapeut effect safeti differ diseas clinic trial take potenti interact consider | D002957 | T002;T168 |
34,687,439 | train covid lockdown knowledg belief practic athlet countri six contin object explor train relat knowledg belief practic athlet influenc lockdown respons coronavirus diseas covid pandem caus sever acut respiratori syndrom coronavirus sar cov | D000086382 | T047;T067 |
34,687,438 | extracellular buffer supplement improv exercis capac perform comprehens systemat review meta analysi extracellular buffer supplement sodium bicarbon sb sodium citrat sc sodiumcalcium lactat slcl ergogen supplement although question remain factor may modifi effect | D017079;D058573 | T039;T121;T201 |
34,687,436 | glioma molecular signatur crossroad tumor microenviron patient glioblastoma averag surviv time current treatment short main due recurr resist therapi insuffici treatment success larg part due tremend molecular heterogen glioma affect overal prognosi respons therapi play vital role glioma grade addit tumor microenviron major player glioma develop resist therapi activ communic glioma cell local neighbor healthi cell immun environ promot cancerogen process contribut establish glioma stem cell drive therapi resist besid genet alter primari tumor tumor releas factor cytokin protein extracellular vesicl environment influenc like hypoxia provid tumor cell abil evad host tumor surveil machineri promot diseas progress moreov increas evid player affect molecular biolog properti glioma enabl inter cell communic support pro cancerogen cell properti identifi character complex mechan inevit necessari adapt therapeut strategi develop novel measur provid updat junction constant traffic biomolecul add complex manag glioblastoma | D001932;D005909;D005910 | T191 |
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