PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,687,714 | mass spectrometri base phosphoproteom system biolog approach studi lymphocyt activ exhaust lymphocyt respond extracellular cue recogn clear foreign bodi function tight regul receptor mediat intracellular signal transduct pathway phosphoryl cascad result rewir transcript cell adhes metabol pathway lead chang downstream effector function includ cytokin secret target cell kill given pathway becom dysregul chronic diseas cancer auto immun diabet persist infect map cell signal dynam normal patholog state central understand modul immun system behavior despit recent advanc remain much learn studi cell signal system level applic global phospho proteom profil technolog potenti provid unpreced insight molecular network govern cell function includ captur spatiotempor dynam cell respons ensembl interact compon rather static view singl point time review describ innov experiment approach studi signal mechan tcr co stimulatori receptor synthet signal molecul chimer antigen receptor inhibitori receptor cell exhaust technic advanc mass spectrometri system biolog framework emphas pois identifi current unknown function relationship depend creat causal predict model expand tradit narrow reductionist len singular compon isol | D008213 | T043 |
34,687,712 | flank disord fold hub domain radic induc cell death affect transcript factor bind ensembl redistribut protein intrins disord essenti organ transcript regulatori interactom interactom major transcript factor well interact partner co exist order disord yet littl attent paid interplay investig order affect flank disord fold hub domain rst radic induc cell death rcd central larg interactom transcript factor show intrins disord c termin tail rcd rst shift conform ensembl toward pseudo bound state weak interact ligand bind pocket unfold excit state also access ms timescal independ surround disord region popul lower presenc flank disord addit lower transcript factor bind affin without affect dissoci rate constant accord similar bound state assess nmr extens dynam rcd rst domain modul flank disord suggest adapt mani differ transcript factor ligand studi illustr disord flank region tune fold function ensembl redistribut relev modular protein general mani play key role regul gene | D018506;D017510 | T044;T045 |
34,687,709 | prognosi metal concentr sediment water paraopeba river follow collaps b tail dam brumadinho mina gerai brazil januari b dam crrego feijo mine locat brumadinho municip mina gerai brazil collaps inject near mm iron fe manganes mn rich tail paraopeba river studi assess contribut tail contamin sediment water metal dataset built daili week sampl execut two year follow event site locat along paraopeba plus site locat confluenc main tributari result evidenc distinct contribut sector anomal km downstream dam natur km anomal sector present larg feal mnal ratio sediment thus rich tail natur sector present small ratio compar natur sediment stream flow discharg paraopeba caus pronounc drop feal mnal ratio anomal sector attribut mixtur contamin sediment main water cours uncontamin sediment inject tributari event non linear regress show feal mnal declin anomal sector relat tail mobil downstream concentr fe al sediment correl posit correspond concentr paraopeba water condit rais discharg rate variat water ph contribut tail fe correl demonstr direct relat establish mn concentr water stream discharg manganes associ fine particl tail mobil water column even low flow preliminari result season autoregress integr move averag model predict return paraopeba pre collaps condit year | D014867;D014874 | T131;T121;T197 |
34,687,708 | bind strength mercuri ii differ dissolv organ matter role dom properti sourc dissolv organ matter dom influenc environment fate toxic effect trace metal mercuri hg howev limit dom analyt techniqu lack sampl divers past studi remain unclear whether bind strength dom complex hg ii relat dom properti studi differ dom isol n various sourc use determin condit stabil constant logk dom hg complex use equilibrium dialysi ligand exchang edl method uv vis fluoresc spectrometri use evalu correl logk valu dom properti chromophor moieti aromat molecular weight result demonstr dom differ sourc present extens rang bind strength hg ii heterogen properti moreov dom chromophor includ aromat molecular weight critic indic dom hg affin ambient relev circumst signific higher terrestri dom led greater dom hg affin addit studi support uv vis fluoresc spectroscopi use estim dom composit bind strength hg ii furthermor observ relationship logk dom properti provid possibl pathway explan spatial co variat hg ii concentr dom charact observ previous field investig | D008628 | T131;T196 |
34,687,707 | differ characterist microbi divers special function microb rainwat topsoil new coronavirus epidem inner mongolia grassland grassland ecosystem vital terrestri ecosystem area sensit climat chang critic assess effect global climat chang china grassland account land area current limit inform microbi divers evolut differ grassland area particular microorgan ice nucleat activ ina potenti resourc potenti influenc regul region precipit climat use illumina miseq sequenc rrna v v hypervari region perform simpl droplet freez experi determin variat grassland microbi communiti speci composit communiti structur rainwat topsoil sampl hulunbuir grassland inner mongolia collect three year character domin bacteri genus rainwat massilia domin fungus cladosporium addit domin bacteria soil sphingomona domin fungus gibberella differ microbi communiti coronavirus diseas epidem pathogen microorgan exhibit inconsist respons environment chang low relat abund known high ina microorgan higher freez temperatur indic unknown high effici biolog ice nucleat particl may present found signific differ speci divers rich rainwat soil popul grassland area analyz sampl communiti structur research result reveal speci composit structur microbiota grassland ecosystem china indic environment media human activ may affect microbiota grassland area indic under microorgan high ina | D017934;D064307 | T032;T001;T028;T005 |
34,687,706 | rhizospher metabol effect phosphorus pool root zone submerg macrophyt isot kirkii presenc oxygen lake sediment reduc sediment oxygen demand potenti improv sediment phosphorus retent coupl nitrificationdenitrif howev releas oxygen root macrophyt previous measur high reduc sediment high reduc environ commerci garden soil sediment hyper eutroph lake use nine oxygen optod place onto scintil vial detect oxygen rhizospher isoet kirkii refer quillwort calcul rhizospher metabol use night time regress method design estim stream metabol reach scale incub sediment collect vial without macrophyt subject sequenti phosphorus extract lag period light avail increas oxygen concentr vari individu optod use improv accuraci metabol estim postul repres distanc root optod higher sediment oxygen demand lake sediment caus kirkii higher root oxygen releas plant grown garden soil may push plant lake sediment close abil surviv evid signific negat relationship root oxygen releas increas sediment oxygen demand indic photosynthesi decreas sediment oxygen demand increas plant would longer abl oxygen sediment surround root would like lead death final presenc quillwort lake sediment signific increas store metal oxid recalcitr phosphorus lake sediment garden soil | D010758;D064028 | T002;T196;T197 |
34,687,705 | asbesto mine wast impact sedimentolog evolut bcancour chain lake southern quebec canada centuri ce asbesto mine activ thetford mine region result accumul gigant miner wast pile bank bcancour river southern quebec canada river widen downstream mine site form chain lake success stater pond trout lake lake william lake joseph previous paleolimnolog investig reveal wast eros transport strong modifi pollut trout lake howev question remain extent mine contamin within bcancour river basin impact spatial scale aim address lack knowledg analyz sedimentolog evolut stater pond lake william joseph bcancour upstream refer site radiometr date pb cs c analys geochem composit icp aesicp ms comput tomographi magnet suscept loss ignit grain size perform sediment core retriev site contrast lake bcancour yet similar trout lake found stater pond lake william receiv high miner matter load sinc creation lake asbesto mine recent lake sediment downstream site high enrich magnesium chromium nickel comparison geochem signatur sedimentari sourc materi within drainag basin demonstr predomin origin mine wast eros issu stater pond lake trout william nowaday expos high sediment accumul rate cm yr g cm yr heavi metal enrich evid contamin also found lake joseph indic wast transport deposit km downstream mine site studi highlight high risk danger associ asbesto pollut aquat ecosystem | D001194;D017753;D060106;D014874 | T082;T083;T131;T197;T070 |
34,687,704 | alter microbiom aquat macroinvertebr riparian spider downstream municip wastewat effluent municip wastewat treatment plant wwtps contain numer contamin includ antimicrobi could affect composit benefici bacteri communiti associ host aquat organ also potenti effect transfer terrestri predat riparian spider five famili aquat macroinvertebr collect site upstream downstream two wwtps waterloo kitchen discharg grand river ontario canada whole bodi microbiota analyz follow extract pcr amplif sequenc bacteri dna use v v hypervari region rrna genet barcod chang relat abund major microbiom phyla observ downstream aquat insect except hydropsychida caddisfli exhibit littl site variat shannon alpha divers differ among site tetragnathida spider perlida hydropsychida heptageniida downstream waterloo wwtp alpha divers decreas spider downstream kitchen wwtp measur decreas perlida increas spider bray curti beta divers dissimilar among site invertebr taxa upstream site differ downstream waterloo spider perlida hydropsychida downstream kitchen spider perlida hydropsychida final effluent deriv bacteria found microbiom downstream spider aquat insect upstream overal result indic microbiom invertebr collect downstream differ collect upstream wwtps implic alter host health transport wwtp deriv bacteria aquat ecosystem | D064307;D013112 | T032;T001;T028;T204 |
34,687,703 | reduc mitochondri dna copi number occup worker bromin flame retard manufactur plant decabromin diphenyl ether bde substitut decabromodiphenyl ethan dbdpe two flame retard similar structur wide use various industri product accumul potenti toxic human health alreadi arous attent research show may affect mitochondri function therefor studi focus popul high exposur bromin flame retard bfrs relat chang mtdna copi number mtdnacn whole blood blood sampl collect three group peopl shandong provinc includ bde occup exposur worker bde manufactur plant dbdpe occup exposur worker dbdpe manufactur plant non bfrs occup exposur resid bfrs contamin area measur level bde dbdpe serum sampl mtdnacn whole blood sampl analyz data multipl linear regress averag concentr bde dbdpe bde dbdpe bde occup worker ngg lw respect averag concentr bde dbdpe bde dbdpe dbdpe occup worker ngg lw respect averag concentr bde dbdpe bde dbdpe non bfrs occup exposur resid ngg lw respect relat mtdnacn bde occup worker dbdpe occup worker non bfrs occup exposur resid fold increas bde dbdpe concentr separ associ decreas mtdnacn therefor studi impli bfrs may affect mitochondri function increas bfrs exposur emerg recent year relationship bfrs exposur mitochondri function need studi | D005411 | T120 |
34,687,702 | polym amend regul cadmium migrat cadmium contamin cotton field insight genet adapt phenotyp plastic polym materi wide use remedi soil heavi metal contamin good perform absorpt metal ion reveal effect polym amend pa remedi cadmium contamin cotton field cadmium cd fraction soil cd concentr cotton organ bioconcentr factor bcf cd transloc factor tf cd antioxid capac photosynthesi function leav evalu combin transcriptom metabolom analys barrel experi field flower boll form stage cotton result show cotton improv toler cd self regul cd contamin soil express oxoglutar acid jasmon acid regul applic pa improv photosynthet rate chlorophyl content chlorophyl fluoresc antioxid enzym activ function leav regul express jasmon acid regul express stearic acid reduc exchang cd concentr soil reduc transport cd root boll therebi balanc genet adapt phenotyp plastic cotton achiev cell structur leav restor studi deepen understand molecular mechan pa remedi cd contamin cotton field provid guidanc remedi heavi metal contamin farmland soil agricultur safeti drip irrig | D002104;D011108 | T131;T104;T122;T196 |
34,687,701 | post translat regul proteolyt activ metalloproteinas adamt disintegrin like metalloproteas domain thrombospondin type motif adamt secret proteas recent implic pathogenesi pulmonari arteri hypertens pah howev substrat repertoir adamt regul activ incomplet understood although consid proteoglycanas high sequenc similar close phylogenet relationship proteoglycan degrad proteas adamt well tight genet linkag adamt human chromosom aggrecanas activ report weak sever post translat factor known regul adamt proteas autolysi inhibit endogen inhibitor receptor mediat endocytosi impact adamt unknown show adamt undergo autolysi six differ site within spacer domain also found contrast adamt adamt level regul low densiti lipoprotein receptor relat protein lrp mediat endocytosi addit adamt lack signific activ proteoglycan aggrecan versican biglycan instead found adamt cleav osteopontin phosphoprotein whose express upregul pah multipl adamt cleavag site identifi use liquid chromatographi tandem mass spectrometri osteopontin cleavag adamt effici inhibit timp endogen inhibitor adamt well timp previous report inhibitori activ adamt proteas differ post translat regul substrat repertoir differenti adamt famili member may help elucid role pah | D011499;D059748 | T040;T044 |
34,687,700 | itih novel serum biomark earli gastric cancer diagnosi gastric cancer gc one lethal form cancer due absenc tool earli detect explor critic biomark earli diagnosi | D013274 | T191 |
34,687,699 | activ infer select attent cocktail parti problem paper introduc new generat model activ infer account preparatori select attent context classic cocktail parti paradigm setup pair word present simultan left right ear instruct spatial cue direct attent left right use generat model test compet hypothes way human listen direct preparatori select attent show assign low precis word attend relat unattend locat explain listen report word compet sentenc model tempor chang sensori precis need account faster reaction time longer cue target interv necessari explain ramp effect event relat potenti erp resembl conting negat variat cnv preparatori interv simul reveal differ process like underli improv reaction time ramp erp associ spatial cue | D013067 | T041 |
34,687,698 | systemat review meta analysi alter electrophysiolog marker perform monitor obsess compuls disord ocd gill de la tourett syndrom gts attent deficithyperact disord adhd autism alter perform monitor implic obsess compuls disord ocd gill de la tourett syndrom gts attent deficithyperact disord adhd autism conduct systemat review meta analysi electrophysiolog correl perform monitor error relat negat ern error posit pe feedback relat negat frn feedback p individu ocd gts adhd autism compar control particip associ correl symptomstrait condit meta analys studi particip show increas ern ocd hedg g cis gts g cis ocd also show increas pe g cis frn g cis adhd autism show reduc ern adhd g cis autism g cis adhd also show reduc pe g cis find suggest overlap electrophysiolog marker perform monitor alter four common neurodevelopment condit increas amplitud marker ocd gts decreas amplitud adhd autism implic find term share distinct perform monitor alter across neurodevelopment condit discuss prospero pre registr code crd | D001289;D001321;D009771;D005879 | T048;T047 |
34,687,695 | midterm outcom cardiac magnet reson imag follow multisystem inflammatori syndrom children midterm follow visit perform median month iqr month patient multisystem inflammatori syndrom children resolut left ventricular dysfunct resolut coronari aneurysm cardiovascular magnet reson imag patient late gadolinium enhanc | D008279 | T170;T059;T060 |
34,687,694 | implement nutrit care bundl improv weight gain extrem preterm infant week postmenstru age evalu effect nutrit care bundl improv growth prematur infant neonat hospit | D064872;D047928 | T046;T061 |
34,687,692 | socioeconom status vision care servic ontario canada popul base cohort studi test associ materi depriv util vision care servic young children | D012923 | T080;T098 |
34,687,691 | volumetr capnographi week postmenstru age bronchopulmonari dysplasia preterm infant assess feasibl volumetr capnographi spontan breath preterm infant week postmenstru age pma associ clinic marker lung diseas includ durat respiratori support bronchopulmonari dysplasia bpd | D019296;D007234;D012121;D012720 | T100;T060;T081;T061;T033;T080 |
34,687,690 | matern exposur air pollut associ neonat jaundic retrospect cohort studi evalu associ matern ambient pollut exposur neonat jaundic multipl pollut speci examin sex differ | D000393;D000397;D051556;D007567 | T047;T184;T131;T080;T069 |
34,687,688 | feed growth outcom infant type c esophag atresia undergo earli primari repair describ growth feed outcom patient type c esophag atresia underw earli primari repair identifi predictor poor growth | D002657 | T040;T039 |
34,687,687 | health risk sulfentrazon exposur zebrafish embryo larva develop environment concentr knowledg negat effect mechan sulfentrazon sul aquat earli life stage still limit investig lethal sub lethal effect sul zebrafish embryo larva develop result demonstr h h lc sul embryon zebrafish mgl lc mgl embryo expos sul high concentr sul delay yolk sac absorpt disord hatch heart rate zebrafish embryon stage mgl sul phenotyp chang embryon develop decreas bodi weight larva exposur rna seq identifi differenti express gene larva embryo expos mgl mgl mgl sul found transcript profil involv heart develop endocrin disrupt simultan influenc differ concentr sul adrenerg signal cardiomyocyt cardiac muscl contract cell adhes molecul steroid biosynthesi biochem analysi show sul increas level e tsh induc activ mitochondri complex iv cytochrom c oxidas ca atpas total na k atpas ca mg atpas decreas atp format embryo expos sul comprehens analysi demonstr sul caus signific alter transcript level activ key element involv heart develop endocrin disrupt exposur indic long term sul exposur might caus negat effect zebrafish dose presum observ advers effect level earli life develop result infer environment concentr sul might caus potenti cardiac endocrin health risk zebrafish later life stage also facilit better understand sub lethal effect molecular mechan sul aquat organ | D014874;D015027 | T131;T013 |
34,687,686 | pharmaceut person care product aquat environ remov alga base system consumpt pharmaceut person care product ppcps wide increas yet ppcps consum human excret unmetabol moreov ppcps fulli remov wastewat treatment plant wwtps releas ppcps natur water bodi affect aquat ecosystem potenti human studi sought review occurr ppcps natur water bodi global assess effect import factor flux pollut receiv waterway highest ibuprofen concentr ngl tap water report nigeria highest naproxen concentr ngl report groundwat well penn state usa moreov ppcps affect aquat organ fish instanc ngg atenolol detect p lineatus amongst differ technolog elimin ppcps alga base system environment friend effect photosynthet abil alga absorb co flexibl grow differ wastewat triclosan less trimethoprim remov nannochlori sp green alga moreov variabl concentr ppcps might advers affect growth product alga exposur alga high concentr ppcps reduc content chlorophyl protein due produc reactiv oxygen speci ros affect express gene chlorophyl rbcl psba psab psbc | D003358;D004364 | T167;T121;T073 |
34,687,685 | distribut behavior budget pb suspend particl changjiang estuari adjac east china sea content isotop budget pb suspend particul matter spm changjiang estuari adjac east china sea ec determin investig biogeochem cycl particul pb coastal sea content particul pb rang gg februari winter gg august summer except surfac water particul pb content august higher februari lower water particul pb th spm decreas gradual estuari toward sea indic lithogen origin changjiang river particul pb display abnorm high concentr februari surfac water result atmospher deposit anthropogen pb winter pb pb pb pb surfac water north estuari higher background valu suggest anthropogen disturb pb particul pb content changjiang river estuari increas due pollut pb also scaveng organ matter lead higher pb content water high product budget particul pb northern ec establish changjiang river contribut particul pb input summer winter half year respect particul pb deposit estuari adjac coastal sea summer export southward coastal current winter | D063366;D014874 | T070;T131 |
34,687,684 | rapid detoxif microcystin lr select catalyt hydrogen adda moieti use tio support pd catalyst hepatotox microcystin lr mc lr main caus adda moieti studi use tio support pd catalyst select hydrogen cc bond adda moieti achiev rapid detoxif mc lr water ambient condit mc lr remov within min catalyt hydrogen pd tio catalyst dosag normal rate constant l mg cat min signific effici catalyt treatment method reaction proceed high select manner toward catalyt hydrogen cc bond mdha moieti subsequ conjug doubl bond adda moieti yield two intermedi one final product upon catalyt hydrogen min pd tio toxic mc lr assess protein phosphatas activ assay drastic decreas demonstr effect detoxif influenc catalyst support pd content initi mc lr concentr reaction ph catalyt stabil examin surfac adsorpt cation pd play crucial role reaction kinet result suggest catalyt hydrogen high effect safe strategi detoxifi mc lr select reaction | D018508 | T052;T057 |
34,687,683 | post fabric structur chang enhanc photodegrad activ semiconductor zeolit composit toward noxious contamin review articl provid recent progress semiconductor base zeolit photoact materi applic noxious contamin remov rapid expand industri global caus serious threat environ water bodi semiconductor zeolit photocatalyst implement water qualiti managementsustain exclus properti zeolit materi elabor role photocatalysi process photoact materi properti like singl atom catalyst sac distribut metal zeolit crystal elabor along role catalyt reaction differ prepar semiconductor zeolit composit tio zeolit binari ternari composit feagbismuth modifiedznoznsniog c n core shellquantum dot modifi zeolit composit systemat summar research progress morpholog structur effect degrad mechan recapitul tabul form degrad optim paramet catalyst dose pollut concentr ph light sourc intens also provid signific zeolit framework structur properti semiconductor zeolit photoact materi enhanc degrad effici explor analysi intermedi product norfloxacin tcdd tetrachlorodibenzo p dioxin tcdf tetrachlorodibenzofuran diclofenac contamin systemat repres structur identifi gc mshplc ms techniqu | D017641 | T197 |
34,687,682 | green initi oil sand cleanup use chitosanrhamnolipid complex dispers ph stimulus respons releas oil affect vulner shorelin environ oil spill happen coastal water strand oil shorelin persist pose long term influenc intertid ecosystem weather therefor shorelin cleanup techniqu requir remov oil shorelin environ studi new shorelin cleanup initi use chitosanrhamnolipid csrl complex dispers ph stimulus respons develop oil sand cleanup result factori singl factor design reveal csrl complex dispers maintain high remov effici oil sand differ level oil content comparison use rhamnolipid alon howev increas salin negat affect remov effici electrostat screen effect high ionic strength hinder format csrl complex thus reduc remov effici ph respons characterist chitosan allow easi separ water oil wash effluent chitosan polyelectrolyt aggreg precipit due deproton amino group adjust ph wash effluent microscop imag demonstr chitosan aggreg wrap around oil droplet settl bottom togeth thus achiev oil water separ ph stimulus respons may help achiev easi oil water separ wash find import implic develop new strategi oil spill respons | D048271;D010578;D059392;D014874 | T131;T069;T121;T109 |
34,687,681 | photolysi induc advanc reduct process remov tribromophenol reduct process import type pollut remov technolog particular organ halogen anion pollut common present wastewat studi novel advanc reduct process arp induc photolysi develop remov tribromophenol tbp uvno format acid fa process achiev remov improv debromin tbp initi tbp concentr mm howev coexist advers affect reduct remov compon acid condit ph studi benefit remov debromin tbp cl promot remov uvno fa howev decreas debromin effect tbp humic acid typic dissolv organ matter suppress remov tbp degrad debromin experiment condit methyl viologen signific inhibit perform arp verifi role co arp insuffici reduct reduct observ differ condit greater amount nh form influenc tbp data also indic much remov convert noteworthi due reduct radic generat oxid fa oxid reduct product tbp detect effluent result studi provid potenti technolog reduct remov organ halogen rich wastewat | D000090422;D014874 | T131;T109 |
34,687,680 | cs select adsorpt revers ca illit ca vermiculit understand predict cs behavior soil groundwat cs adsorpt properti illit vermiculit investig various ph condit cs concentr cs adsorpt desorpt experi conduct ca homoion illit ca vermiculit cacl solut ionic strength moll respect focus cation exchang cs proton calcium thermodynam equilibrium ca illit display affin cs ca vermiculit cs adsorpt non linear clay miner multi site exchang model approach adopt interpret model adsorpt isotherm miner reactiv describ sorption site properti express exchang capac ionic select high select low capac site shown control cs uptak concentr moll ca illit ca vermiculit three high capac site domin cs adsorpt higher concentr cs adsorpt revers demonstr illit ca concentr rang moll partial irrevers cs adsorpt onto vermiculit cs concentr greater moll relat interlay collaps revers adsorpt may occur long interlay space stay open irrevers adsorb fraction quantifi taken account model approach calcul select coeffici site | D008903 | T197 |
34,687,679 | layer filter paper silver nanoparticl zif composit effici multi mode enrich sensit ser detect thiram ser substrat fpagzif compos filter paper fp silver nanoparticl agnp zeolit imidazol framework zif film arrang layer structur develop sensit detect pesticid thiram various sampl role compon analyt adsorpt raman signal enhanc studi use pesticid intermedi aminothiophenol atp probe substrat show high adsorpt optim ser respons thick metal organ framework mof coat nm differ previous report plasmon particl mof composit substrat thinnest mof coat produc strongest ser signal detect limit atp improv fold fpagzif pm compar fpag nm import fpagzif porous flexibl properti effici captur pesticid thiram differ real sampl use soak filtrat swab oper subsequ ser detect thiram show advantag low detect limit soak lod nm lake water fast detect filtrat within min peach juic suitabl curv surfac analysi swab lod ngcm appl peel respect substrat also display good reproduc high stabil size select respons thiram detect layer plasmon particlemof hybrid may hold great promis toxic analysi environ food | D053768;D017641 | T073;T197 |
34,687,678 | electrochem degrad perform mechan dibutyl phthalat hydrophob pbo electrod polytetrafluoroethylen ptfe dope pbo anod high hydrophob fabric electrodeposit method process vertic align tio nanotub tio nts form anod oxid ti plate intermedi layer pbo electrodeposit character electrod indic ptfe success introduc electrod surfac tio nts complet cover pbo particl gave larg surfac area also limit growth crystal particl compar convent tipbo titio ntspbo electrod titio ntspbo ptfe electrod enhanc surfac hydrophob higher oxygen evolut potenti lower electrochem imped activ site generat hydroxyl radic oh enhanc addit ptfe nanoparticl electrocatalyt perform three electrod investig use dibutyl phthalat dbp model pollut effici dbp remov three electrod order titio ntspbo ptfe titio ntspbo tipbo degrad process follow pseudo first order kinet model well rate constant h three electrod respect lowest energi consumpt kwh g obtain h dbp treatment use titio ntspbo ptfe compar titio ntspbo kwh g tipbo kwh g electrod moreov effect current densiti initi ph electrolyt concentr investig final product dbp degrad process verifi base gas chromatographi mass spectrometri analysi possibl degrad pathway describ | D003993;D014874 | T131;T121;T109 |
34,687,677 | polychlorin biphenyl pcb concentr profil marin mammal north atlant ocean polychlorin biphenyl pcbs provid crucial inform bioaccumul biomagnif pop marin mammal muscl tissu sampl obtain detail pcb congen specif analysi pcbs speci marin mammal strand across coast uk least pcb congen found individu highest concentr pcbs record killer whale mgkg lipid highest toxic equival risso dolphin pgg teq wet concentr pcbs major sampl exceed toxic threshold mgkg lipid marin mammal highlight health risk face pcb exposur mani pcb profil fit typic aroclor signatur instead indic pattern congen resist biotransform elimin howev studi identifi novel pcb signatur sei whale yet previous observ marin mammal whale pcb profil includ lighter inadvert pcb congen pcb suggest main sourc exposur atmospher deposit rather terrestri discharg seven subsampl chosen chiral analysi pcb enantiom fraction ef c pcbs non racem suggest may enantiom select metabol marin mammal although shift literatur toward emerg pollut studi act stark remind pcbs continu pose signific risk wildlif | D010872;D004785;D011078 | T131;T015;T109 |
34,687,676 | effect electr stimul train bodi composit paramet spinal cord injuri systemat review determin effect neuromuscular electr stimul nmes function electr stimul fes train differ bodi composit paramet individu spinal cord injuri | D004599;D055070;D013119 | T037;T061 |
34,687,675 | reliabl valid respons spinal cord independ measur th version multicultur setup examin fourth version spinal cord independ measur reliabl valid | D004185;D013119 | T037;T060 |
34,687,674 | hypothalam cellular molecular plastic link sexual experi male rat mice male sexual behavior subject learn result increas effici experienc male compar naiv one improv behavior paramet underpin cellular molecular chang neural circuit control sexual behavior particular hypothalam medial preoptic area review provid updat mechan relat sexual experi male rodent emphas differ rat mice | D011301;D012726 | T023;T054 |
34,687,673 | mathemat model retin pigmentosa trophic factor hypothesi retin pigmentosa rp term use denot group inherit retin degen condit caus progress sight loss individu condit lose light sensit photoreceptor cell known rod cone period year decad degener start retin peripheri spread peripher central time rp rod cone dystrophi mean rod health function affect earlier sever cone rod degener due under mutat wherea reason cone degener unknown number mechan propos explain secondari cone loss spatio tempor pattern retin degener rp one promis trophic factor hypothesi suggest rod produc factor necessari cone surviv rod degener cone degener follow paper formul analys mathemat model human rp trophic factor hypothesi model construct system reaction diffus partial differenti equat one spatial dimens solv analys use combin numer analyt method predict condit cone degener follow loss patch rod retina critic trophic factor treatment rate requir prevent cone degener follow rod loss spatio tempor pattern cone loss would result trophic factor mechan alon respons retin degener | D012162;D012174 | T047;T046 |
34,687,670 | qualiti activ pharmaceut ingredi present algerian soil control impur ciprofloxacin metronidazol fluconazol medicin qualiti defin aptitud meet certain requir declar regulatori author among impur control constitut major fear pharmaceut manufactur effici safeti term nowaday mani develop countri presenc poor qualiti drug common reason increas control institut includ impur repres serious public health problem threaten efficaci safeti medicin nocuous repercuss health object studi verifi impur certain api ciprofloxacin metronidazol fluconazol actual collect algerian soil meet impur requir | D004340;D008795 | T121;T068;T109 |
34,687,667 | ration dispar health care implic radiolog clinic practic guidelin examin relationship ration health care resourc dispar health care deliveri specif implic radiolog resourc alloc framework acr appropri criteria explor ration context manifest radiolog review ration taken mani form ration influenc develop dispar access outcom within health care specif within context radiolog describ relationship ration health care deliveri dispar manifest coronavirus diseas pandem correct measur propos establish ration framework facilit equit pandem relat resourc distribut offer suggest regard solut might brought radiolog resourc alloc scheme help mitig dispar radiolog care futur | D015276;D054625;D011871 | T058;T080;T091 |
34,687,666 | navig clue success academia academ success achiev take divers form depend ask suggest happi impact longev achiev profession effort support balanc toil joy one chosen path | D006240 | T041 |
34,687,665 | sinusoid transform visual field basi period map area v retinotop map mani visual area thought follow fundament principl describ primari visual cortex v nearbi point retina map nearbi point surfac v orthogon axe retin surfac repres along orthogon axe cortic surfac demonstr strike departur map secondari visual area v tree shrew best describ sinusoid transform visual field sinusoid topographi ideal achiev uniform coverag elong area like v predict mathemat model design wire minim provid novel explan period band pattern intra cortic connect function respons properti v tree shrew well sever speci find suggest cortic circuit flexibl implement solut sensori surfac represent dramat consequ larg scale cortic organ | D014793;D014794 | T082;T023;T029 |
34,687,664 | forebrain neural substrat behavior thermoregul thermoregulatori behavior basic motiv behavior bodi temperatur homeostasi despit fundament import forebrain region defin neural popul requir process yet establish show vgat express neuron later hypothalamus lh vgat neuron requir divers thermoregulatori behavior popul activ lh vgat neuron increas thermoregulatori behavior bidirect encod thermal punish reward p r although popul also regul feed calor reward inhibit parabrachi input select impair thermoregulatori behavior encod thermal stimulus lh vgat neuron furthermor two photon calcium imag reveal subpopul lh vgat neuron bidirect encod thermal p r engag thermoregulatori behavior larg distinct calor reward encod lh vgat neuron data establish lh vgat neuron requir neural substrat behavior thermoregul point key role thermal p r encod lh vgat subpopul thermoregulatori behavior | D007026;D016548 | T023;T029 |
34,687,663 | visual thalamocort mechan wake state depend activ alpha oscil brain exhibit distinct pattern recurr activ close relat behavior state neural mechan underli state depend activ awak anim incomplet understood demonstr two type state depend activ rapid arousalmov relat signal hz alpha like rhythm primari visual cortex v mice strong correl activ visual thalamus inactiv v interrupt arousalmov signal visual thalam neuron abolish hz oscil silenc visual thalamus similar erad alpha like rhythm perturb arousalmov relat activ v intracellular record thalam neuron reveal hz oscil associ rhythmic low threshold ca spike result indic thalamocort interact ionotrop signal togeth cell intrins properti thalamocort cell play crucial role shape state depend activ v awak anim | D013788;D014851 | T023;T041 |
34,687,659 | right intern thorac arteri patenc affect target choic conduit configur although coronari arteri bypass graft use bilater intern thorac arteri ita maxim long term surviv knowledg effect differ right ita rita inflow configur graft patenc limit compar rita occlus among configur identifi risk factor adjust outflow coronari target locat | D008323 | T023 |
34,687,658 | digoxin associ greater transplant free surviv high vs low risk interstag patient digoxin associ reduc interstag mortal patient function singl ventricl aortic hypoplasia ductal depend system circul neonat type stage palliat oper postop extracorpor membran oxygen discharg opiat digoxin discharg postop arch obstruct moder sever tricuspid regurgit without oxygen requir extra oxygen requir discharg patient moder sever tricuspid regurgit score stratifi patient risk death transplant dtx basi clinic factor studi investig suspect variabl transplant free surviv benefit digoxin high risk vs low risk patient | D018636;D058327;D053610;D014262 | T047;T121;T109;T131;T061 |
34,687,655 | spontan remiss cush diseas systemat review spontan remiss rare cush diseas describ one illustr case provid systemat review case previous report literatur case report year old woman diagnos cush diseas underw month isol metyrapon treatment two month end treatment admit acut kidney failur anoth month june evid hypercortisol either clinic biochem hypocortisol time write year later still remiss case report literatur patient report includ present case femal median age year ten radiolog visibl tumor microadenoma macroadenoma mean time diagnosi spontan remiss month shorter macroadenoma month microadenoma month treatment spontan remiss treatment steroidogenesi enzym inhibitor bilater adrenalectomi adren autotransplant partial bilater adrenalectomi incomplet pituitari surgeri pituitari tumor apoplexi frequent incrimin event radiolog document patient mean remiss follow month rang month recurr occur n patient although sever mechan respons phenomenon propos clinic subclin pituitari tumor apoplexi latter sometim present atyp seem frequent incrimin event doctor awar regular follow mandatori due unpredict | D012075 | T070 |
34,687,654 | design rational phase studi neurotoxin botulinum toxin type prevent post oper atrial fibril nova studi post oper af poaf common complic follow cardiac surgeri occur patient undergo bypass andor valv surgeri poaf associ longer intens care unithospit stay increas healthcar util increas morbid mortal inject botulinum toxin type epicardi fat pad result reduct af anim model two clinic studi cardiac surgeri patient without new safeti observ | D001281;D019274;D006348 | T116;T047;T121;T109;T129;T046;T131;T061 |
34,687,653 | conceptu util translat clinic genom research prior integr clinic care novel medic innov typic assess term balanc benefit risk often refer util member multidisciplinari research team may conceptu assess util differ way implic within translat genom communiti evid base upon clinic guidelin group healthcar payer make decis ambigu conceptu util translat genom research lead communic challeng within research team studi design meet stakehold need seek address ambigu challeng describ conceptu understand util use term scholar field philosophi medicin social scienc decis psycholog health econom illustr applic field orient translat genom research use exampl clinic sequenc evid generat research cser consortium provid recommend increas clariti cohes futur research given differ understand util align greater lesser degre import stakehold view precis use term help research better integr multidisciplinari investig communic stakehold | D003210;D023281;D057170 | T091;T062;T041 |
34,687,652 | cold exposur protect neuroinflamm immunolog reprogram autoimmun energet cost impact metabol activ state immun immun mediat diseas unclear lyc hi monocyt key effector cns autoimmun elus role prime naiv autoreact cell provid unbias analysi immun chang various compart cold exposur show energet cost stimulus mark amelior activ experiment autoimmun encephalomyel eae cold exposur decreas mhcii monocyt steadi state various inflammatori mous model suppress cell prime pathogen modul monocyt genet antibodi mediat monocyt deplet adopt transfer th th polar cell eae abolish cold induc effect cell eae respect find provid mechanist link environment temperatur neuroinflamm suggest competit cold induc metabol adapt autoimmun energet trade benefici immun mediat diseas | D004681;D000090862 | T033;T047;T050 |
34,687,651 | histor experi mass drug administr malaria control elimin challeng china experi narrat review decad effort malaria still major public health problem mani countri especi sub saharan africa mass drug administr mda one intervent use control malaria china largest popul countri world recent achiev malaria elimin mda within strategi therefor know histori use mda advantag challeng crucial better implement mda compon malaria control elimin strategi narrat review focus use mda past present experi success fail mda intervent control malaria africa asia south pacif region challeng face well china experi malaria control elimin direct search use key word phrase conduct use web search engin googl googl scholar peer review journal websit pubm databas main screen articl mda studi posit negat result world health organ guidelin mda relat report also summar histor field experi mda malaria control provid inform perspect challeng mda follow spirit innov comprehens strategi mda core addit measur compens one anoth shortag base differ malaria transmiss set stratif could highlight futur malaria control elimin strategi help achiev vision malaria free world | D008288;D000074381 | T047;T061 |
34,687,650 | redescript simulium gomphostilbia omutaens ogata sasa diptera simuliida japan phylogenet relationship member batoens speci group simulium gomphostilbia omutaens ogata sasa name speci simulium batoens speci group subgenus gomphostilbia enderlein record honshu kyushu japan repres northernmost distribut speci group member distribut orient region speci member simulium omutaens subgroup uniqu among seven subgroup batoens speci group pupal gill one long filament seven short filament similar arrang pupal gill filament zonatum subgroup epistum speci group subgenus speci fulli redescrib base adult pupal exuvia matur larva similar speci decuplum subgroup base adult morpholog characterist although pupal gill latter subgroup mark differ short filament close relationship decuplum subgroup support dna analysi use coi gene sequenc genet distanc hand genet distanc g omutaens speci zonatum subgroup studi show similar arrang pupal gill two differ speci group rare seen evolv independ occurr necessarili reflect phylogenet relationship | D031787;D012843 | T204;T002 |
34,687,649 | associ anthelmint treatment malaria preval incid parasitemia systemat review meta analysi chronic helminth infect alter host immun respons affect malaria infect conduct systemat review meta analysi find impact anthelmint treatment malaria preval incid parasitemia nine electron databas search th juli th june relev studi perform meta analysi malaria preval incid parasitemia qualit synthesi effect anthelmint treatment seventeen relev paper includ associ anthelmint treatment malaria preval chang parasitemia end follow period pool ci p valu smd ci p valu respect defin time point analysi pool analysi three studi demonstr associ malaria incid anthelmint treatment rate ratio ci p valu studi encourag anthelmint treatment countri high burden co infect anthelmint treatment associ chang malaria preval incid parasitemia | D000871;D008288 | T047;T121 |
34,687,648 | molecular evid support valid three parabrachiella speci infect mugilid parasit copepod genus parabrachiella compos speci found south america find new specimen parabrachiella mugili turkey allow us compar nucleotid sequenc mitochondri cytochrom c oxidas subunit coi gene speci south american parabrachiella exili parabrachiella platensi speci parasit mugilid addit specimen parabrachiella fasciata parabrachiella orali parabrachiella dispar chile parabrachiella chevreuxi argentina includ comparison result confirm three parabrachiella speci parasit mugilid identifi morpholog valid entiti howev p exili recent synonym p mugili latter speci show great genet distanc p exili closer parabrachiella fasciata speci long posterior process parabrachiella exili p platensi parasit mugil cephalus mugil liza respect low genet distanc parabrachiella kabatai parasit isacia conceptioni low genet distanc p fasciata p platensi p exili addit three parasit copepod south america short round posterior process compar speci long posterior process speci long posterior process cluster togeth pacif ocean clade p hugu north pacif ocean except p chevreuxi found south atlant ocean studi add seven new sequenc make total nine sequenc south american speci parabrachiella | D033342;D023701 | T204;T013 |
34,687,647 | effect algin nanoparticl immunogen excretori secretori antigen acut toxoplasmosi murin model efficaci algin nanoparticl alg nps vaccin deliveri excretori secretori antigen esa virul strain toxoplasma gondii evalu swiss albino mice intraperiton immun three dose either vivo vitro prepar esa vaccin g week interv challeng tachyzoit rh hxgprt toxoplasma gondii strain four week later mice mortal tachyzoit number periton fluid impress smear viabil ultrastructur tachyzoit chang measur immunolog marker histopatholog chang liver spleen studi comparison alum adjuv esa infect control subgroup vivo prepar alg nps load esa vaccin subgroup induc signific reduct mice mortal tachyzoit count periton fluid impress smear viabil scan electron microscopi reveal tachyzoit deform multipl irregular transmiss electron microscopi show tachyzoit distort disrupt plasma membran loss nuclear integr absenc dens granul extens vacuol statist signific increas level ifn anti toxoplasma igg note histopatholog result record amelior patholog chang induc toxoplasma infect liver spleen scanti parasit therefor alg nps prove effect enhanc esa antigenc recommend test potenti drug carrier anti toxoplasma agent enhanc therapeut efficaci | D053758;D016052;D014122;D014123;D014124 | T047;T121;T073;T129;T204 |
34,687,646 | comparison multi epitop recombin antigen dipol hydatid fluid diagnosi patient cystic echinococcosi use serolog test contain multipl immunodomin antigen rather singl antigen potenti improv diagnost perform cystic echinococcos ce complement tool clear inconclus imag data compar evalu diagnost valu hydatid fluid hf recent describ recombin multi epitop antigen dipol igg elisa clinic defin cohort ce patient serum sampl ce patient collect surgic percutan aspir inject reaspir pair procedur addit serum sampl patient parasit infect n healthi individu n also includ studi control investig associ genotyp parasit dipol cyst materi ce patient sequenc term overal sensit hf higher dipol respect howev sensit hf higher dipol patient activ transit cyst respect sensit dipol inact cyst higher compar hf respect sensit dipol depend cyst stage statist signific p term specif dipol found better hf respect genotyp major patient show g genotyp patient harbor g gg cyst genotyp posit antigen patient g genotyp seroposit hf dipol overal sensit high specif dipol suggest recombin protein contain immunodomin epitop potenti substitut hf serolog test diagnosi ce | D004443;D048209 | T204;T047 |
34,687,644 | drug associ altern complementari therapi neglect tropic diseas present paper aim establish differ treatment neglect tropic diseas survey drug conjug possibl fix dose combin fdc use obtain altern safer effect treatment sourc databas use scienc direct pubmedmedlin interv drug key word diseas like schistosomiasi praziquantel malaria artesun chaga diseas benznidazol filariasi diethylcarbamazin ivermectin albendazol work object intens analysi articl document use increas qualiti studi consensus harmon therapeut histor articl result effect ntd control achiev differ public health approach combin intervent guid epidemiolog locat avail appropri measur detect prevent control diseas also possibl verifi fdcs promot simplif therapeut regimen promot better patient complianc enabl reduct develop parasit resist requir studi aim resist strain sinc combin api usual act differ mechan differ target site addit elimin process develop new drug base identif valid activ compound complex long process requir strong long term invest advantag fdcs relat product gain gain industri plant favor encourag r new fdcs ntds also diseas requir use one drug | D000529;D004364;D012552 | T091;T047;T121;T061 |
34,687,643 | develop molecular biolog identif tool mycetoma causat agent updat mycetoma chronic granulomat inflammatori diseas caus either bacteria fungi bacteri mycetoma actinomycetoma caus various causat agent genera nocardia streptomyc actinomadura hand fungal mycetoma eumycetoma common caus causat agent belong genera madurella scedosporium falciformispora earli accur diagnosi causat organ guid proper patient manag treatment allow rapid accur speci identif differ molecular techniqu develop past decad techniqu protein base maldi tof ms well dna base sequenc pcr isotherm amplif method review provid overview differ molecular techniqu current use identifi knowledg gap need address implement molecular diagnost mycetoma differ clinic set | D020461;D008271 | T004;T047 |
34,687,642 | trypanosoma cruzi dna desmodus rotundus common vampir bat histiotus montanus small big ear brown bat chile protozoan trypanosoma cruzi causat agent chaga diseas transmit infect fece consumpt blood suck triatomin insect sever mammalian order includ chiroptera chile distribut sever insectivor one hematophag bat speci overlap triatomin vector cruzi infect status local chiropteran unknown live captur bat two protect area chile collect plagiopatagium tissu fece perian swab sampl search cruzi dna real time pcr assay use speci specif primer pan de azcar island examin roost desmodus rotundus common vampir bat sampl tissu individu detect cruzi dna five las chinchilla nation reserv examin two roost histiotus montanus small big ear brown bat collect fece perian swab sampl eight individu detect cruzi dna four first report cruzi dna evid bat speci chile vector born oral transmiss potenti infect rout explain result investig need better understand role bat cruzi transmiss cycl | D014355;D002685;D014349 | T204;T015;T047 |
34,687,641 | comparison elisa use recombin lipl sonic antigen leptospira detect bovin leptospirosi leptospirosi one wide distribut zoonosi world bovin leptospirosi serious problem bovin product caus reproduct loss aim work compar recombin lipl sonic antigen detect anti leptospira igg antibodi bovin serum use elisa microscop agglutin test mat use gold standard sonic antigen cultur leptospira interrogan serogroup icterohaemorrhagia serovar copenhageni strain use eelisa rlipl relisa perform assay evalu use serum sampl bovin mat posit mat negat optim cut point recommend receiv oper characterist roc curv analysi sensit specif valu respect eelisa respect relisa valu area roc curv ci eelisa ci relisa roc curv rlipl sonic antigen show statist signific differ z p three way comparison show statist signific differ sensit specif relisa eelisa result show eelisa specif sensit relisa differ perform eelisa relisa ci sensit ci specif result show eelisa better diagnost perform relisa detect anti leptospira igg antibodi bovin serum | D007919;D007922 | T007;T047 |
34,687,640 | first identif telomer dna sequenc trichomona vaginali trichomoniasi common nonvir sexual transmit diseas caus trichomona vaginali serious threaten human reproduct health telomer specialis dna protein complex end chromosom protect function aim present studi identifi characteris telomer dna vaginali previous report multipl molecular method includ sequenc bal nucleas bal nucleas assay fluoresc situ hybridis fish southern blot found numer repeat unit ttttaggg vaginali genom dna digest nucleas combin xbai restrict enzym ttttaggg n tandem repeat also high sensit bal exonucleas digest confirm ttttaggg n repeat locat end vaginali chromosom fish restrict enzym digest combin southern blot use digoxigenin label ttttaggg probe show vaginali telomer dna length vari kb first report telomer dna sequenc vaginali includ length distribut chromosom find lay foundat studi telomer mainten mechan vaginali | D014245;D014246 | T204;T047 |
34,687,639 | role manganes dysregul neurolog diseas emerg evid manganes essenti trace metal dysregul manganes seen broad spectrum neurolog disord reflect import brain develop key neurophysiolog process histor observ acquir mangan miner peopl misus drug provid earli evid brain toxic relat manganes exposur identif inherit manganes transportopathi caus neurodevelopment neurodegen syndrom corrobor neurotox potenti element moreov manganes dyshomoeostasi also implic parkinson diseas neurodegen condit alzheim diseas huntington diseas ongo futur research facilit develop better target therapeut strategi current avail manganes associ neurolog disord | D020149;D019636;D010300 | T047;T037 |
34,687,638 | neocort develop epilepsi insight focal cortic dysplasia brain tumour past decad consider advanc understand genet morphogen process under cortic malform development brain tumour focal malform caus somat postzygot variant gene relat cell growth ie mtor pathway focal cortic dysplasia type acquir neuron progenitor neurodevelop comparison development brain tumour result somat variant gene relat cell prolifer eg map kinas pathway ganglioglioma affect prolifer glioneuron precursor time genet event specif gene involv neurodevelop drive natur size lesion whether development malform brain tumour also emerg evid epigenet process underli molecular memori epileptogenesi knowledg togeth facilit understand patient lesion epilepsi could form basi move toward precis medicin challeng cohort patient | D001932;D004827;D018303;D054220;D019579 | T191;T047;T023;T019;T033;T024 |
34,687,637 | alzheim diseas associ syndrom genet form dementia adult syndrom develop neuropatholog hallmark alzheim diseas high risk develop earli onset dementia lead caus death popul diagnosi dementia remain clinic challeng lack valid diagnost criteria popul symptom overshadow intellectu disabl associ syndrom peopl syndrom fluid imag biomark shown good diagnost perform strike similar tempor chang respect sporad autosom domin alzheim diseas import treatment prevent alzheim diseas even though adult syndrom could optim popul conduct alzheim diseas prevent trial unpreced research activ syndrom rapid chang bleak scenario translat diseas modifi therapi could benefit popul | D000544;D004314;D008607 | T048;T047 |
34,687,636 | safeti toler activ mesenchym stem cell versus placebo multipl sclerosi mesem phase randomis doubl blind crossov trial mesenchym stem cell mscs also known mesenchym stromal cell propos promis therapeut option peopl multipl sclerosi basi immunomodulatori neuroprotect properti mesenchym stem cell multipl sclerosi mesem studi devis evalu safeti toler activ autolog mscs deriv bone marrow infus intraven patient activ multipl sclerosi | D054220;D059630;D009103 | T025;T047;T019 |
34,687,635 | apixaban versus anticoagul anticoagul associ intracerebr haemorrhag patient atrial fibril netherland apach af randomis open label phase trial patient atrial fibril surviv anticoagul associ intracerebr haemorrhag decis must made whether restart perman avoid anticoagul best long term strategi prevent recurr stroke vascular event apach af aim estim rate non fatal stroke vascular death patient treat apixaban compar anticoagul avoid inform design larger trial | D001281;D020521 | T047;T046 |
34,687,634 | safeti efficaci losartan reduct brain atrophi clinic diagnos alzheim diseas radar trial doubl blind randomis placebo control phase trial drug modifi angiotensin ii signal could reduc alzheim diseas patholog thus decreas rate diseas progress investig whether angiotensin ii receptor antagonist losartan compar placebo could reduc brain volum loss measur diseas progress clinic diagnos mild moder alzheim diseas | D000544;D019808 | T048;T047;T121;T109 |
34,687,616 | clinic patholog featur renal present polycythemia vera polycythemia vera pv common type philadelphia chromosom negat chronic myeloprolif disord pv associ kidney diseas rare report remain poor understood observ chronic kidney diseas could risk factor poor prognosi pv | D005922;D011087;D051436 | T191;T047 |
34,687,611 | mode speciat recent radiat open ocean phytoplankton despit enorm ecolog import marin phytoplankton surpris littl known new phytoplankton speci origin evolv open ocean absenc appar geograph barrier typic act isol mechan speciat investig mechan open ocean speciat combin fossil climat record late quaternari genom wide evolutionari genet analys speciat ubiquit abund pelag coccolithophor genus gephyrocapsa includ g huxleyi former known emiliania huxleyi base analysi sequenc genom report best fit scenario speciat event analyz includ extend period complet isol follow recent holocen secondari contact support role geograph oceanograph barrier popul diverg speciat consist fossil data reveal consider diachron speci first occurr time speciat event coincid glacial phase glacial interglaci cycl suggest stronger isol ocean basin increas segreg ecolog nich glaciat import driver speciat marin phytoplankton similar across multipl speciat event impli general infer speciat scenario marin phytoplankton | D058087;D010839 | T204;T002 |
34,687,610 | new westward migrat rout asian passerin bird evolut migrat rout bird remain poor understood chang migrat strategi rare observ contemporari timescal richard pipit anthus richardi migratori songbird breed siberian grassland winter southeast asia recent becom regular autumn winter visitor western europ examin whether chang occurr mere reflect increas number vagrant lost individu like manag return breed ground repres new migratori strategi show richard pipit southwestern europ true migrant mark individu return southern franc subsequ winter geo local track reveal origin western edg known breed rang make astonish km journey central asia across eurasia unusu longitudin westward rout among siberian migratori bird climat nich model use citizen scienc bird data suggest winter nich suitabl increas southwestern europ may led increas winter surviv eventu success return journey reproduct individu initi reach europ autumn vagrant illustr vagranc may underestim role emerg new migratori rout adapt global chang migratori bird whatev under driver mechan constitut one document contemporari chang migrat rout first longitudin shift long distanc migratori bird | D046109;D020308 | T012 |
34,687,609 | multispeci bco beak color polymorph darwin finch radiat carotenoid base polymorph widespread popul bird fish reptil general littl known factor affect mainten popul report combin field molecular genet investig nestl beak color polymorph darwin finch beak pink yellow yellow recess show polymorph aros galpago half million year ago mutat associ regulatori chang bco gene share descend speci polymorph probabl balanc polymorph maintain ecolog select associ surviv diet cactus finch frequenc yellow genotyp correl cactus fruit abund greater hatch success may alter introgress hybrid polymorph hidden adult may far common current recogn contribut diversif way yet discov | D001502;D046369 | T023;T012 |
34,687,608 | turnov fear engram cell repeat experi spars popul neuron activ learn event identifi memori engram cell howev cell recruit support memori experi repeat scarc explor evid previous studi provid contradictori view address question employ learn depend cell label later amygdala la appli electrophysiolog record spine imag optogenet tool label neuron without retrain found engram cell establish origin fear learn becam dispens memori retriev specif relearn correl reduct synapt transmiss loss dendrit spine neuron despit decreas connect direct activ neuron result fear memori recal identifi repeat memori encod neuron activ relearn result suggest shift neuron ensembl encod fear memori la relearn disconnect exist engram neuron establish origin experi | D066272;D005239 | T023;T041 |
34,687,605 | abil frailti measur predict short term outcom older patient admit post acut inpati rehabilit evalu abil common use frailti measur predict short term clinic outcom older patient admit post acut inpati rehabilit | D015673;D000073496 | T033;T047;T184;T046 |
34,687,604 | induc intra intermolecular templat switch therapeut mechan rna virus viral rna depend rna polymeras rdrps target broad spectrum antivir therapeut agent recent demonstr incorpor triphosph pyrazin carboxamid ribonucleotid nascent rna increas paus backtrack poliovirus rdrp monitor enterovirus rdrp dynam rna synthesi use magnet tweezer identifi backtrack state intermedi use rdrp copi back rna synthesi homolog recombin cell base assay rna sequenc rna seq experi demonstr pyrazin carboxamid ribonucleotid stimul process infect result suggest pyrazin carboxamid ribonucleotid induc lethal mutagenesi chain termin function promot templat switch format defect viral genom conclud rdrp catalyz intra intermolecular templat switch induc pyrazin carboxamid ribonucleotid defin addit mechanist class antivir ribonucleotid potenti broad spectrum activ | D011995 | T045 |
34,687,603 | increas actla occup within mswisnf chromatin remodel drive human squamous cell carcinoma mammalian swisnf baf chromatin remodel play dosag sensit role mani human malign neurolog disord gene encod baf subunit actin like actla amplifi earli develop mani squamous cell carcinoma sccs oncogen role remain unclear demonstr actla overexpress lead stoichiometr assembl baf complex drive interact engag specif regulatori region genom normal epitheli cell actla substoichiometr baf subunit howev increas actla level ectop express scc cell led near satur actla within baf complex increas actla occup enhanc polycomb opposit genom wide activ scc gene facilit co depend load baf tead yap complex chromatin mechan appear critic function molecular gate scc initi mainten therebi explain specif role actla amplif sccs | D042002 | T045 |
34,687,602 | har benefit avail target therapi acut myeloid leukaemia research result regulatori approv nine agent acut myeloid leukaemia indic us food drug administr sinc bcl inhibitor venetoclax two flt inhibitor midostaurin gilteritinib two idh inhibitor ivosidenib idh inhibitor enasidenib idh inhibitor anti cd antibodi drug conjug gemtuzumab ozogamicin oral poor absorb hypomethyl agent azacitidin liposom formul cytarabin daunorubicin ratio cpx hedgehog signal pathway inhibitor glasdegib absorb oral formul hypomethyl agent decitabin approv treatment myelodysplast syndrom chronic myelomonocyt leukaemia might use altern parenter hypomethyl agent sever approv singl agent therapi specif combin narrow indic thus offer poor treatment valu review discuss ongo research combin contain commerci avail target therapi acut myeloid leukaemia | D000970;D015470 | T191;T121;T109 |
34,687,601 | consensus diagnosi manag cush diseas guidelin updat cush diseas requir accur diagnosi care treatment select long term manag optimis patient outcom pituitari societi conven consensus workshop compris academ research clinic expert discuss applic recent evid clinic practic advanc virtual meet data present screen diagnosi surgeri medic radiat therapi diseas relat treatment relat complic cush diseas summaris record lectur review particip meet concis summari record lectur present follow small group breakout discuss consensus opinion group collat draft document review approv particip recommend regard use laboratori test imag treatment option present along algorithm diagnosi cush syndrom manag cush diseas topic consid import address futur research also identifi | D003480;D047748 | T047 |
34,687,600 | new model palliat approach care australia inconsist provis palliat end life palliat care across australia particular region rural remot area systemat solut help address identifi gap improv access qualiti care support patient famili carer end life far west new south wale nsw palliat end life model care systemat solut rural remot palliat approach care model enabl consist contextu adapt patient focus palliat approach care everyon receiv care need appropri skill inform clinician time manner close home possibl | D010166;D019035 | T058;T073;T093;T061 |
34,687,599 | assess explor forens nurs concept undergradu nurs curricula mix method studi purpos studi assess import explor inclus forens nurs concept undergradu nurs curricula | D004508;D013338 | T097;T065 |
34,687,598 | long term use proton pump inhibitor advers affect miner vitamin metabol bone turnov bone mass bone strength notwithstand proton pump inhibitor ppis one excel option differ anti secretori therapi term improv symptomat outcom numer epidemiolog cohort studi provid evid associ long term proton ppis use increas fractur risk among user present attempt aim summar effect long term use ppis musculoskelet system consid recent claim differ research group understand risk osteopenia osteoporosi determin risk factor associ complic extract data various systemat review meta analys cross section studi prospect studi case control studi cohort studi vivo vitro studi observ consequ long term ppis use patient bone health recent find suggest long term use ppis play introductori cabalist role develop osteoporosi most hip fractur disturb numer biolog pathway thus abl set link prescript ppis bone loss frequent administr ppis associ signific wors outcom bone miner densiti bmd profil produc negat impress bone health sinc limit data determin associ ppis use chang bmd recommend studi find dissert | D015519;D010024 | T081;T047;T201 |
34,687,597 | lipas elev serum covid patient frequenc extent increas clinic valu previous studi report lipas elev serum covid patient tri establish causal link sar cov infect pancreat damag howev degre preval hyperlipasemia uniform across studi | D000086382 | T047;T067 |
34,687,596 | pattern pain complaint insomnia symptom associ abus supervis norwegian work popul latent class analysi previous find suggest abus supervis ie subordin percept supervisor behaviour hostil exclud physic aggress may increas risk health complaint addit recent data suggest fkbp genotyp rs import regul cortisol releas influenc outcom ad complex differ health complaint often co occur present studi aim uncov pattern pain complaint insomnia symptom use latent class analysi determin whether abus supervis fkbp rs associ pattern examin interact abus supervis fkbp genotyp regard pain insomnia symptom | D007319 | T048;T047;T184 |
34,687,595 | evalu circul dickkopf prognost biomark ovarian cancer patient dickkopf dkk secret protein known suppress differenti activ bone build osteoblast act inhibitor wnt signal solubl dkk sdkk propos prognost biomark wide rang malign howev clinic relev sdkk potenti blood base marker ovarian cancer unknown | D010051;D010534 | T191 |
34,687,593 | youtub tm adequ sourc oral hygien educ orthodont patient present studi aim assess qualiti reliabl content inform provid youtub tm video oral hygien orthodont treatment reveal efficaci video patient help dentist use platform sourc guid patient accur | D061108 | T170 |
34,687,592 | cross cultur adapt turkish version parent caregiv percept questionnair p cpq parent caregiv percept questionnair p cpq one scale use evalu qualiti life children dental cari import factor affect oral health relat qualiti life aim translat turkish evalu psychometr properti p cpq evalu dental cari status year old children | D017028;D003731 | T047;T098;T099;T097;T033 |
34,687,591 | quantif marin benthic communiti metabarcod dna metabarcod method implement studi aim detect quantifi marin benthic biodivers survey univers barcod amplifi sequenc environment dna quantifi biodivers dna metabarcod relat number dna sequenc speci biomass andor abund requir howev relationship complic mani factor often unknown studi valid estim biomass abund molecular approach tradit morpholog approach abund biomass quantifi sampl benthic intertid mudflat use tradit morpholog approach compar frequenc occurr relat read abund estim molecular approach relationship biomass relat read abund found two wide dispers annelid taxa pygospio scoloplo none taxon howev show relationship discuss quantif abund biomass use molecular approach hamper ecolog dna ie process determin amount dna environ includ ecolog benthic speci well composit natur sequenc data | D058893;D000080309 | T062;T087;T114 |
34,687,590 | chromosom scale genom assembl annot spring orchid cymbidium goeringii cymbidium goeringii common known spring orchid long favour horticultur purpos asian countri popular orchid much demand improv develop valuabl varieti refer genom publish despit popular conserv effort report de novo assembl c goeringii genom largest among orchid publish date use strategi combin short long read sequenc chromosom conform captur hi c inform total length scaffold gb n scaffold size mb total protein code gene annot gb genom repetit sequenc identifi construct pseudomolecular chromosom use hi c incorpor scaffold chromosom identifi expand contract gene famili c goeringii diverg close relat also identifi new gene famili resist gene analogu chang within mad box gene control divers set development process orchid evolut high qualiti chromosom level assembl c goeringii provid platform elucid genom evolut orchid mine function gene agronom trait develop molecular marker acceler breed well acceler conserv effort | D029595;D000069600 | T040;T002 |
34,687,589 | systemat character absorb compon ligustri lucidi fructus metabol pathway rat plasma ultra high perform liquid chromatographi q exact orbitrap tandem mass spectrometri combin network pharmacolog ligustri lucidi fructus dri matur fruit ligustrum lucidum ait effect nourish liver kidney herein accur sensit method establish separ identif absorb constitu metabolit ligustri lucidi fructus rat plasma base ultra high perform liquid chromatographi q exact orbitrap tandem mass spectrometri total prototyp constitu metabolit identifi character administ plasma possibl metabol pathway constitu main involv hydroxyl sulfat demethyl glucuronid besid network pharmacolog investig illumin potenti mechan treatment liver injuri biolog target regul relat pathway network pharmacolog analysi show target compon target regul pathway dock result show key target compon close relat liver injuri overal studi clear present metabol process ligustri lucidi fructus gave comprehens metabol profil ligustri lucidi fructus vivo first combin network pharmacolog molecular dock discov potenti drug target disclos biolog process ligustri lucidi fructus viabl step toward uncov secret mask studi tradit chines medicin | D000091484 | T062;T170 |
34,687,587 | rejuven earlob esthet dermal filler extern ear play signific aesthet role appear face chronolog extrins age effect ear lobe get pronounc sinc routin surgic aesthet procedur face address morpholog chang ear adorn jewelri pierc caus sag ear lobe stretch ear pierc dermal filler offer viabl option ear lobe rejuven increas volum address morpholog chang minim advers effect downtim associ surgeri | D003357;D000067548;D015595 | T033;T042;T122;T061 |
34,687,586 | extract purif cation exchang supermacropor cryogel physico chemic character conglutin lupin seed lupinus albus l studi focus extract purif physicochem character conglutin protein present lupin seed properti reduc blood glucos level total protein extract alkalin salin solvent follow isoelectr precipit chromatograph purif precipit fraction perform use cation exchang supermacropor cryogel column electrophoresi elut fraction chromatographi present singl band kda non reduc condit two band kda reduc condit confirm success purif protocol liquid chromatographi tandem mass spectrometri analysi confirm ident protein conglutin purifi conglutin isoelectr point sheet prevail secondari structur denatur temperatur close c outcom work show conglutin obtain high degre puriti propos purif protocol simpl easili scale | D031297 | T002 |
34,687,585 | sar cov infect among hospitalis pregnant women impact differ viral strain covid sever itali nation prospect popul base cohort studi primari aim articl describ sar cov infect among pregnant women wild type alpha variant period itali secondari aim compar impact virus variant sever matern perinat outcom | D000086382;D011251;D000086402 | T047;T005;T067 |
34,687,584 | kidney transplant outcom children adolesc system lupus erythematosus literatur support equival kidney transplant outcom adult system lupus erythematosus sle compar without sle howev conflict scant data kidney transplant outcom well controversi optim time transplant children adolesc sle | D016030 | T061 |
34,687,583 | identif subcellular local function comparison novel yap splice isoform mous embryon stem cell hippo signal pathway involv mani biolog process includ fate decis embryon stem cell esc yes associ protein yap function key effector hippo pathway role esc still controversi far two isoform yap identifi overlap distinct function identifi six novel isoform mous yap bring total number isoform eight accord differ first exon divid two subtyp b isoform isoform b exhibit differ subcellular local moreov isoform fulli revers impair self renew phenotyp induc yap knockout ko upon overexpress isoform moder promot mesc self renew mark delay differenti contrari signific pro self renew phenotyp observ isoform b overexpress wildtyp wt mesc express yap ko cell line find help clarifi role yap mesc also lay foundat advanc function research yap process | D001686;D000066450 | T070;T038;T025 |
34,687,582 | demograph infer climat nich model shed light evolutionari histori emblemat cold adapt apollo butterfli region scale cold adapt speci escap climat warm latitudin andor altitudin rang shift current occur southern europ isol mountain rang within sky island studi genet structur apollo butterfli five sky island franc infer demograph histori sinc last interglaci use singl nucleotid polymorph ddradseq snps auvergn alp popul show strong genet differenti alpin massif although separ deep valley combin three complementari demograph infer method speci distribut model sdms show lig period high unfavour apollo probabl surviv small popul highest summit auvergn popul shift downslop expand eastward lig lgm throughout larg climat suitabl rhne valley glaciat summit auvergn alp auvergn alp popul start diverg lgm remain larg connect till mid holocen popul declin auvergn gradual start kya vs ya much stronger current popul size ten time lower alp alp low genet structur limit evid isol distanc suggest nonequilibrium metapopul function core apollo popul experienc cycl contract expans climat fluctuat larg interconnect popul overtim accord metapopul pulsar function studi demonstr power combin demograph infer sdms determin past futur evolutionari trajectori endang speci region scale | D002080 | T204 |
34,687,581 | effect mind base intervent psychotherapi process systemat review field psychotherapi scientif research highlight import empathi therapeut allianc regard effect better result psycholog treatment recent year mind base intervent mbis shown effect increas empathi therapeut allianc could affect patient symptomatolog studi conduct systemat review effect mbis appli psychotherapist improv empathi therapeut allianc patient symptomatolog sixteen studi evalu impact mbi variabl identifi six includ measur evalu patient whose psychotherapist receiv mbi risk bias includ studi analys follow methodolog standard found differ design methodolog studi includ review includ control group result show limit increas empathi measur psychotherapist mbi howev result therapeut allianc conclus well improv percept patient symptomatolog conclud mbis benefici effect psychotherapeut practic develop psychotherapist empathi futur research would requir new studi higher methodolog qualiti effect mbis empathi therapeut allianc patient symptomatolog relationship analyz | D064866;D000078462 | T041;T078 |
34,687,580 | dna methyl sexual dimorph new insight mealybug dna methyl ancient epigenet pathway found across eukaryot nevertheless target dna methyl within genom evolv extrem rapid arthropod display mani exampl mealybug planococcus citri evolv methyl promot sequenc associ gene silenc mammal issu molecular ecolog bain et al thorough characteris mealybug methyl explor potenti function gene express spectacular sexual dimorph characterist speci result provid new insight complex relationship dna methyl gene express highlight rapid differ methyl system evolv | D001181;D019175 | T044;T204 |
34,687,579 | risk predict metastasi clear cell renal cell carcinoma use digit multiplex ligat depend probe amplif precis quantif copi number alter cnas tumor genom difficult appli comprehens copi number analysi method digit multiplex ligat depend probe amplif digitalmlpa target gene copi number analysi clear cell renal cell carcinoma ccrcc copi number status chromosom arm gene determin ccrcc sampl chromosom p loss q gain known earli chang ccrcc develop well loss p q detect respect gene express analysi signific posit correl detect term q loss determin use digitalmlpa downregul mrna express ratio hifa lhgdh p respect patient earli metastasi n show cnas arm median wherea metastasi free patient n show signific less arm arm median p particular biallel delet cdknab associ multipl cnas arm tumor togeth sequenc level mutat gene vhl pbrm setd bap perform multipl correspond analysi identifi associ p loss q loss earli metastasi p analysi indic associ p loss p loss poor surviv p find suggest cnas essenti role aggress ccrcc show approach measur cna digitalmlpa facilit select patient may develop metastasi | D056915 | T086;T045 |
34,687,578 | function role graft infiltr lymphocyt earli phase post transplant mous cardiac transplant model immunolog behavior graft infiltr lymphocyt gil determin graft fate ie reject accept nevertheless function alloreact phenotyp gil various time earli post transplant phase fulli elucid examin immunolog activ earli phase gil use murin model cardiac transplant gil h allograft h allograft show robust activ produc proinflammatori cytokin particular signific increas cd bet nur cell detect h allograft furthermor isol gil use reconstitut balbc rag c brg mice brg mice reconstitut h gil display donor specif immun reactiv reject donor strain cardiac allograft convers h gil exhibit weak anti donor reactiv reject allograft find confirm transplant cardiac allograft brg mice h post transplant transplant allograft continu function day despit presenc cd gil conclus immunolog behavior gil consider differ time earli post transplant phase better understand function role earli phase gil may clarifi fate determin process graft site microenviron | D016027 | T061 |
34,687,577 | tarnish silver spoon trade prenat growth telomer length wild boar life histori theori predict trade growth rate lifespan reflect telomer length biomark somat state investig correl telomer length earli life growth wild boar piglet sus scrofa kept semi natur condit high food avail examin hypothesi increas pre postnat growth lead telomer length attrit high suppli nutrient may provid possibl compens telomer loss via telomer repair mechan predict data show clear negat correl birth bodi mass initi telomer length heavier neonat shorter telomer birth find influenc mother initi telomer length bodi mass birth correl bodi mass later life postnat growth rate affect telomer length observ increas telomer length postnat develop suggest high food avail allow piglet invest growth telomer restor increas telomer length durat studi accompani telomeras activ thus telomer elong caus either altern mechan short puls telomeras activ miss taken togeth studi suggest trade invest growth telomer mainten even birth possibl compens telomer attrit growth high amount avail energi | D012834;D059506 | T049;T196 |
34,687,575 | diagnosi treatment cryptococc osteomyel pediatr lung transplant patient asymptomat pulmonari nodul may appear point lung transplant differenti diagnosi broad includ serious life threaten diseas entiti | D016040;D014057 | T060;T061 |
34,687,573 | health literaci communic decis make outcom among cancer patient famili clinician india multicentr cross section qualit studi cancer patient india prefer full inform regard diagnosi prognosi evid suggest poor insight studi aim identifi role health literaci among adult patient live cancer famili health profession decis make treatment outcom india | D057220;D009369 | T191;T041 |
34,687,571 | n myc downstream regul famili member ndrg enrich myelin oligodendrocyt impact myelin degrad respons demyelin n myc downstream regul gene famili member ndrg gene whose mutat result peripher neuropathi central manifest previous studi character ndrg role schwann cell detect central nervous system symptom identif ndrg gene silenc white matter multipl sclerosi brain rais question regard role oligodendrocyt show ndrg enrich oligodendrocyt myelin prepar character express use novel report mous tgndrg egfp report ndrg express development myelin remyelin cuprizon induc demyelin adult corpus callosum transcriptom ndrg egfp cell support identif late myelin oligodendrocyt character express gene regul lipid metabol bioenerget also generat lineag specif condit knockout olig cre ndrg flfl line studi function null mice develop normal despit similar number progenitor cell wild type fewer matur oligodendrocyt lower level myelin protein control therebi suggest ndrg import mainten late myelin oligodendrocyt addit control ndrg null mice subject cuprizon induc demyelin observ higher degre demyelin mutant togeth data identifi ndrg import molecul adult myelin oligodendrocyt whose decreas level normal appear white matter human ms brain may result greater suscept myelin damag | D009103;D009186 | T026;T047;T024 |
34,687,570 | steroid free mainten immunosuppress use alemtuzumab pediatr kidney transplant long term longitudin follow scarciti long term data steroid free immunosuppress use alemtuzumab pediatr kidney transplant ktx studi examin long term outcom alemtuzumab without steroid mainten therapi pediatr ktx | D016030 | T061 |
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