PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,687,285 | comparison two definit bronchopulmonari dysplasia prematur infant bronchopulmonari dysplasia bpd common respiratori diseas prematur infant still differ understand definit bpd therefor studi intend compar main clinic result health econom expenditur differ bpd definit | D001997;D007235 | T047 |
34,687,284 | comparison inhal mannitoldornas alfa combin daili dornas alfa alon children cystic fibrosi inhal recombin human deoxyribonucleas dornas alfa osmot agent inhal mannitol use improv clearanc secret cystic fibrosi cf patient aim evalu long term clinic effect ad dri powder inhal dpi mannitol subject cf take daili dornas alfa | D003550 | T047 |
34,687,283 | systemat assess quaternari ammonium compound potenti elicit development reproduct effect quaternari ammonium compound quat common found clean product disinfect hand sanit person care product use year consid safe use accord direct recent paper report reduc fertil neural tube defect rodent low level exposur determin quat interfer mammalian reproduct develop conduct method assess avail data | D004202;D000644 | T167;T131;T109 |
34,687,282 | screen diabet retinopathi fluorescein angiographi patient type diabet adolesc adult life retrospect studi past year clinic practic tertiari belgian centr aim present studi describ preval progress dr diagnos fluorescein angiographi fa patient type diabet td year follow relationship glycat haemoglobin hbac | D003922;D003930 | T047 |
34,687,281 | risk factor bleed hepatocellular adenoma unit state cohort known risk factor hepatocellular adenoma hca bleed size cm growth rate visibl vascular exophyt lesion catenin sonic hedgehog activ hcas studi base european cohort object studi identifi addit risk factor hca bleed us cohort | D018248;D006528;D008113 | T191 |
34,687,280 | clinic characterist peopl cystic fibrosi frequent fungal infect individu cystic fibrosi cf fungal airway infect may present fungal bronchiti allerg bronchopulmonari aspergillosi abpa may appear unaffect despit fungal detect sought character peopl cf frequent detect fungi airway sampl determin clinic outcom | D001229;D003550 | T047 |
34,687,278 | moder effect econom status associ earli life famin exposur mafld adulthood doubl burden malnutrit dbm china result high preval diet relat non communic diseas aim studi analys moder econom status associ earli famin exposur metabol dysfunct associ fatti liver diseas mafld adulthood | D050171;D011297 | T047;T037;T046 |
34,687,277 | descript risk factor analysi infantil cataract nation birth defect prevent studi use nation birth defect prevent studi nbdps data sought estim birth preval describ clinic characterist examin risk factor infantil cataract calcul birth preval use number nbdps elig cataract case live birth studi area describ case infant presenc associ ipsilater eye defect i non eye relat major birth defect use matern exposur inform collect via telephon interview conduct logist regress analys among interview case control birth preval infantil cataract live birth unilater cataract often associ i infant bilater cataract often preterm full term low birth weight non eye relat major birth defect unilater cataract posit associ matern nullipar adjust odd ratio aor confid interv ci refer multipar wherea bilater cataract posit associ matern educ year foreign born nativ aor ci refer us born nativ current analysi inform futur epidemiolog studi aim identifi mechan under associ infantil cataract complex matern exposur lower level educ foreign born nativ | D002386;D018811 | T190;T033;T047;T037 |
34,687,276 | induct cell hsc enrich bmcs co cultur ipsc deriv thymic epitheli cell cell bear antigen receptor investig potenti treatment sever diseas includ malign tumour howev clinic applic cell hamper relat low abund vivo technic difficulti induc differenti hematopoiet stem cell hscs vitro describ novel method generat mous cell co cultur hsc enrich bone marrow cell hsc ebmc induc thymic epitheli cell itec deriv induc pluripot stem cell ipsc use bmcs cd congen cbl mice distinguish ipsc express cd show hsc ebmc itec cultur il il day induc cd cell express broad repertoir v v cell receptor notabl induc lymphocyt contain cell nk natur killer cell b b cell adopt transfer induc cell leukemia bear mice signific reduc tumour growth prolong mous surviv obvious side effect tumorigenesi autoimmun diseas new method suggest could also use produc human cell clinic applic | D002454 | T043 |
34,687,275 | rapid detect infect ascit cirrhosi use metagenom next generat sequenc case seri empir antibiot therapi patient spontan bacteri periton sbp common pathogen identifi patient use convent cultur base techniqu metagenom next generat sequenc mngs test promis approach diagnosi infecti diseas clinic applic mngs infect ascit cirrhot patient rare report describ three case preliminarili explor potenti role mngs microbiolog diagnosi ascit infect exploratori manner clinic perform ascit mngs cirrhot patient remain evalu | D001424;D010538 | T047;T046 |
34,687,273 | attach style affect psychosi systemat review causal mechan guid futur inquiri link attach psychosi well establish less known causal mechan under relationship systemat review synthesis studi examin mediat mechan attach psychosi relationship clinic non clinic sampl | D011618 | T048 |
34,687,272 | use altern assess framework evalu waterborn versus solventborn basecoat use automot refinish evalu two type automot basecoat use automot refinish ie auto bodi shop waterborn solventborn primari tool use evalu altern assess guid version develop interst chemic clearinghous ic term solventborn use articl refer product contain relat high concentr volatil organ compound refer high volatil organ compound voc basecoat industri product distinct low voc solventborn product use wide california elsewher health environment hazard perspect evalu found waterborn basecoat contain fewer hazard ingredi lower concentr solventborn counterpart automot painter spray paint vehicl waterborn product experienc signific lower exposur sever harm solvent waterborn product readili avail offer advantag regard social impact advantag includ lower worker communiti exposur voc reduc voc releas smog format reduc potenti generat exposur hazard wast base assess auto bodi shop consid waterborn basecoat safer altern human health environment perspect integr environ assess manag publish articl us govern work public domain usa | D016273;D055549 | T037;T109 |
34,687,271 | repetit short puls illumin effici activ photoactivat cre continu illumin embryon stem cell pre implant embryo transgen mous cre loxp system wide use specif dna recombin induc gene inactiv express recent photoactivat cre pa cre protein develop tool spatiotempor control enzymat activ cre recombinas generat transgen mice bear pa cre gene systemat investig condit photoactiv pa cre embryon stem cell esc deriv transgen mice simpl mathemat model cre mediat dna recombin induc pa cre esc hr continu illumin show repetit puls illumin effici induc dna recombin low light energi effici continu illumin esc continu illumin puls cycl also support minim mathemat model dna recombin pa cre also success induc transgen mous pre implant embryo develop condit result suggest strategi base repetit puls illumin effici activ photoactivat cre possibl photo switchabl protein | D005818 | T063 |
34,687,270 | lung cancer cell express shorten cdk utr escap senesc impair mir p target induc senesc cancer cell emerg strategi cancer therapi dysregul mutat gene encod cyclin depend kinas cdks implic various human cancer howev whether cdk induc cancer cell senesc remain poor understood observ cdk express high multipl cancer type includ lung cancer wherea various replic senesc model display low cdk express cdk knockdown caus senesc associ phenotyp lung cancer cell line interest cdk utr shorten cancer lengthen senesc model regul altern polyadenyl apa longer utr use distal polya pa site generat less protein shorter one use proxim pa site sinc microrna mirna usual bind utr target gene suppress express investig whether mirna target region shorten longer utr respons reduc express found mir p target utr distal proxim pa site caus senesc associ phenotyp reduc protein product longer cdk transcript note cdk knockdown led reduc express myc proto oncogen bhlh transcript factor myc cd molecul pd l turn enhanc tumor suppress effect senesc cancer cell present studi discov cdk whose express regul apa mir p potenti target prosenesc therapi lung cancer | D008175;D035683 | T191;T114;T123 |
34,687,268 | phlorotannin load homogen acellular matrix film modul post implant inflammatori respons peritendin adhes main occur prolifer fibrous tissu adjac normal organ surgeri mani physic barrier appli implant site prevent peritendin adhes howev barrier often trigger inflammatori respons therefor studi sought develop phlorotannin load cartilag acellular matrix cam film physic barrier investig inhibitori effect inflammatori respons associ induct postop peritendin adhes paa find indic incorpor phlorotannin cam film affect uniqu characterist includ thermal spectroscop properti moreov phlorotannin load cam film suppress express inflammatori mediat raw macrophag stimul use escherichia coli lipopolysaccharid exhibit anti inflammatori effect implant subcutan rat therefor result highlight potenti phlorotannin load cam film promis physic barrier prevent paa | D002356;D008070 | T024;T109 |
34,687,267 | genom wide identif character basic helix loop helix transcript factor spodoptera litura upon pathogen infect basic helix loop helix bhlh transcript factor play import role wide rang metabol development process eukaryot bhlh protein also particip immun respons especi plant howev role insect upon entomopathogen infect unknown studi bhlh gene famili identifi polyphag pest spodoptera litura includ new bhlh gene group b specif present lepidoptera thus name lep conserv amino acid bhlh domain structur architectur chromosom distribut bhlh gene litura analyz bhlh gene plutella xylostella api mellifera also updat genom wide comparison phylogenet analysi bhlh member holometabol insect perform express profil litura bhlh slbhlh gene tissu differ development stage respons litura nucleopolyhedrovirus spltnpv nomuraea rileyi nr bacillus thuringiensi bt infect investig slbhlhs group b express differenti express pathogen infect slbhlhs tend downregul midgut litura larva b thuringiensi treatment studi provid overview bhlh famili member litura respons differ pathogen use pest biocontrol find bhlh member may contribut uncov mechan host pathogen interact | D051792;D017924 | T116;T005;T123 |
34,687,266 | character novel hla c allel two next generat sequenc method novel hla c allel character use two next generat sequenc technolog | D015236;D059014 | T129;T116;T063;T059 |
34,687,264 | character novel hla allel sequenc base type singl nucleotid chang exon hla result novel hla allel | D059014 | T059;T063 |
34,687,263 | qualit quantit proteom metaproteom analys healthi human urin sediment healthi human urin sediment proteom metaproteom investig shed light variat urin sediment protein metaprotein associ sex age | D020543;D040901 | T091;T116;T123 |
34,687,261 | uorf mediat riboregul control transcript whibwblc antibiot resist gene whibwblc transcript factor actinomycet confer intrins resist multipl translat inhibitori antibiot posit autoregul transcript respons antibiot presenc uorf potenti rho independ transcript termin leader region suggest possibl whibwblc gene regul via uorf mediat transcript attenu howev experiment evid molecular mechan explain antibiot stress suppress attenu induc transcript whibwblc gene lack report leader sequenc whibwblc gene sub clade actinomycet includ conserv antitermin rna structur confirm putat antitermin whibwblc leader sequenc streptomyc mycobacterium inde suppress rho independ transcript termin facilit transcript readthrough requir whibwblc mediat antibiot resist antibiot mediat suppress attenu recapitul amino acid starvat indic translat inhibit uorf multipl signal key induc whibwblc express find mechan lead intrins antibiot resist could provid altern treat drug resist mycobacteria | D015964 | T045 |
34,687,258 | arac type regul hilc rtsa direct control intestin fatti acid regul salmonella invas invas intestin epithelium essenti energet expens surviv strategi therefor tight regul use specif cue environ enter pathogen salmonella control invas machineri eleg coordin three arac type transcript activ hild hilc rtsa environment signal target hild control invas wherea hilc rtsa known augment effect hild show fatti acid found murin colon cis hexadeceno acid c hda repress salmonella invas direct target hilc rtsa addit hild c hda direct bind regul inhibit attach dna target repress invas even absenc hild fatti acid bind howev affect hilc rtsa protein stabil unlik hild import show hilc rtsa high effect restor hild product invas gene express elimin repress fatti acid c hda togeth result illumin precis mechan hilc rtsa may modul invas salmonella navig differ region intestin contribut understand enter pathogen sens adapt divers intestin environ maintain virul | D015964 | T045 |
34,687,256 | later border scapular tip free flap old school versus new school free tissu transfer subscapular system provid wide array option soft tissu boni reconstruct bone stock requir head neck reconstruct later scapular border free flap lsbff suppli circumflex scapular arteri scapular tip free flap stff suppli angular arteri excel option issu posit previous prevent widespread use boni subscapular system flap howev use spider limb position current clinic practic pattern allow two team approach free flap follow pictori essay compar contrast specif posit harvest techniqu use lsbff stff discuss clinic advantag drawback later border scapula scapular tip free flap provid excel bone stock head neck reconstruct posit current avail technolog free flap harvest two team approach | D058752;D019651 | T024;T061 |
34,687,255 | fisetin major compon deriv mulberri morus australi poir leav prevent vascular abnorm contract mulberri morus australi poir leav long consum form tea tinctur especi asia owe high antioxid blood pressur regul properti although thought vascular abnorm contract may involv blood pressur suppress effect effect mulberri vascular abnorm contract still unknown therefor investig mulberri leav potenti sourc bioactiv compound prevent vascular abnorm contract mulberri leav divid fresh leav tea leav classifi accord age tree less year old roast unroast mulberri fruit also evalu assess prevent effect mulberri extract vascular abnorm contract extract mulberri leav tree year old show strong prevent effect vascular abnorm contract human coronari arteri smooth muscl cell therefor identifi activ compon mulberri leav fraction activ fraction gel filtrat chromatographi revers phase high perform liquid chromatographi activ fraction analyz mass spectrometri nuclear magnet reson activ compon mulberri leaf extract fisetin addit result indic hydroxyl group c posit fisetin crucial activ result prove fisetin effect prevent vascular abnorm contract overal mulberri leav fisetin expect use wide rang field function food nutraceut drug target | D031625 | T002 |
34,687,254 | retino acid receptor agonist protect alcohol liver diseas modul hepat express canon retinoid metabol gene alcohol abus reduc hepat vitamin retinoid reduct associ progress alcohol liver diseas ald restor hepat retinoid diet contraind ald due negat effect alcohol retinoid metabol current drug mitig alcohol driven hepat retinoid loss progress ald use mous model alcohol intak examin agonist retino acid ra receptor rar ac ac could prevent alcohol driven hepat retinoid loss protect ald result show mice co treat ac alcohol display mitig ald includ reduc macro microvesicular steatosi liver damag alcohol intak led increas hepat centrilobular level aldha rate limit enzym ra synthesi co local aldha alcohol metabol enzym cype hne marker oxid stress express target abrog mice co treat ac alcohol rna sequenc technolog found ac treatment oppos alcohol modul transcript involv canon retinoid metabol alcohol modul transcript includ cesd cesg rbp rdh cypa collect favor hepat retinoid hydrolysi catabol howev despit co administr ac alcohol mitig alcohol mediat deplet hepat retinoid reduc alcohol driven increas serum retinol data show ac protect mice ald even though ac prevent alcohol mediat reduct hepat retinoid data warrant studi anti ald properti ac | D008099;D018168 | T192;T116;T023 |
34,687,253 | evalu heal hard heal venous leg ulcer multicentr prospect random placebo control clinic trial mani patient venous leg ulcer reach complet heal compress treatment alon current standard care clinic trial heal phase iib doubl blind random placebo control studi aim evalu efficaci safeti new drug topic administr combin compress therapi patient suffer hard heal venous leg ulcer studi three arm consist two group treat concentr mgml placebo cohort patient mean age year median ulcer durat month mean wound size time random cm efficaci analysi perform full studi popul identifi signific improv heal patient treat compar placebo contrast post hoc analysi reveal statist signific improv treatment sever interrel heal paramet subgroup patient larg target wound wound area least cm random known negat prognost factor heal studi drug well toler safe dose strength summari clinic trial detect signific differ heal venous lower leg ulcer entir studi cohort compar patient treat versus placebo subgroup analysi provid interest observ could offer treatment benefit patient larg ulcer exig warrant studi adequ power statist assess treatment outcom patient group | D007871;D014647 | T047 |
34,687,252 | chromosom scale genom dipterocarpus turbinatus hopea hainanensi dipterocarpacea provid insight fragrant oleoresin biosynthesi hardwood format dipterocarpacea typic tropic plant dipterocarp forest famous high econom valu product fragrant oleoresin top qualiti timber usag tradit chines medicin current lack dipterocarpacea genom limit factor deciph fragrant oleoresin biosynthesi gain evolutionari insight high qualiti wood format dipterocarpacea generat chromosom level genom assembl two repres dipterocarpacea speci viz dipterocarpus turbinatus gaertn f hopea hainanensi merr et chun whole genom duplic wgd analysi reveal dipterocarpacea underw share wgd event show signific impact increas copi number gene relat biosynthesi terpen bahd acyltransferas fatti acid benzenoidphenylpropanoid probabl confer format characterist fragrant oleoresin addit compar common soft wood plant expans gene famili also found associ wood format cesa cellulos synthas csle cellulos synthas like protein e laccas peroxidas dipterocarpacea genom might also contribut format harder stronger high densiti timber final integr analysi combin genom transcriptom metabol data differ tissu provid insight molecular basi fragrant oleoresin biosynthesi high qualiti wood format dipterocarpacea studi contribut first two repres genom dipterocarpacea valuabl genet resourc research fragrant oleoresin superior qualiti timber genom assist breed improv conserv biolog famili | D053958 | T002 |
34,687,251 | zmte promot plant height regul intercalari meristem format internod cell elong maiz maiz height determin number node length internod node number driven intercalari meristem format internod length intercalari cell elong respect howev mechan regul establish node internod growth unclear screen em induc maiz mutant identifi dwarf mutant zm link singl base chang termin ear zmte detail phenotyp analysi reveal zm zmte shorter internod increas node number caus decreas cell elong disord intercalari meristem format respect transcriptom analysi show auxin signal gene also dysregul zmte cell elong cell cycl relat gene argu zmte regul auxin signal cell divis cell elong found zmwee kinas phosphoryl zmte thus confin nucleus probabl reduc cell divis contrast zmppac phosphatas promot dephosphoryl cytoplasm local zmte well cell divis taken togeth zmte key regul plant height respons maintain organ format internod meristem rapid cell elong zmwee zmppac might balanc zmte activ control cell divis elong maintain normal maiz growth | D018519;D003313 | T168;T002 |
34,687,250 | use antidepress risk repeat self harm older adult nonfat self harm year prospect nation studi assess exposur antidepress ad nonfat self harm sh older adult examin year rate risk factor subsequ sh | D016728;D013405 | T033;T055 |
34,687,249 | metabolom analysi elucid shade condit amelior deleteri effect green huanglongb diseas citrus tropic subtrop environ citrus leav expos excess sunlight induc photoinhibit huanglongb hlb citrus green devast phloem limit diseas putat caus candidatus liberibact asiaticus exacerb challeng addit photosynthet loss excess starch accumul combin metabolom physiolog approach use elucid whether shade allevi deleteri effect hlb field grown citrus tree understand under metabol mechan relat shade induc morpho physiolog chang citrus use metabolit profil multinomi logist regress identifi pivot metabolit alter respons shade core metabol network associ shade condit identifi pathway enrich analysi metabolit map measur physio biochem respons growth yield characterist relationship metabol network variabl measur investig found moder shade allevi sink limit prevent excess starch accumul increas foliar sucros level increas growth fruit yield shade compar non shade tree associ increas photosystem ii effici leaf carbon fixat pathway metabolit studi also show hlb affect tree shade signal plant hormon auxin cytokinin nitrogen suppli downregul reduc new shoot product like due diminish need cell damag repair tissu regener shade overal find provid first glimps complex dynam cellular metabolit leaf physiolog function citrus hlb pathosystem shade reveal mechanist basi shade amelior hlb diseas | D010935 | T047 |
34,687,248 | day hospit enhanc cognit behavior therapi adult eat disord immedi follow effect assess outcom adult patient eat disord administ enhanc cognit behavior therapi cbt e day hospit set | D000856;D015928 | T048;T061 |
34,687,247 | elucid mean life world phenomena phenomenolog hermeneut method research live experi paper phenomenolog hermeneut method interpret narrat text propos interviewe ask tell live experi particip life world phenomena interview text written analys inspir theori interpret paul ricoeur three step first nave read structur analysi comprehens understand method present first time paper theori behind elabor basic concept like phenomenon mean life world live experi concret reflect clarifi histor background method ontolog epistemolog methodolog explain | D033262;D012107 | T170;T081;T169;T062;T078;T096 |
34,687,246 | ultrasonographi spinal cord collect cerebrospin fluid atlanto occipit space goat ultrasonographi non invas use techniqu use examin atlanto occipit space structur visual collect cerebrospin fluid accur easier ultrasound guid procedur studi longitudin transvers view atlanto occipit space scan differ structur dimens measur sixti healthi beetal goat longitudin plane gap skin arachnoidea rang mm mean sd mm depth subarachnoid gap dorsal ventral spinal cord rang mm mean sd mm mean sd mm respect spinal cord diamet vari mm mean sd mm entir dural sac diamet vari mm mean sd mm spinal cord seen longitudin plane distanc mm mean sd mm transvers plane gap skin arachnoidea rang mm mean sd mm depth subarachnoid space dorsal ventral spinal cord vari mm mean sd mm mean sd mm respect spinal cord diamet rang mm mean sd mm entir dural sac diamet vari mm mean sd mm standard measur refer valu healthi beetal goat cerebrospin fluid colourless quantiti ml mean sd ml neither turbid coagul white blood cell count l red blood cell present furthermor total protein glucos also measur rang mgdl mean sd mgdl mgdl mean sd mgdl respect ziehl neelsen stain gram stain negat | D015511;D006041 | T015;T047 |
34,687,245 | natur histori emerg diabet retinopathi microalbuminuria prepuberti earli adulthood type diabet year prospect clinic follow studi evalu impact long term glycaem control glycaem variabl microvascular complic adolesc young adult childhood onset type diabet | D005544;D011627 | T039;T170;T079;T090 |
34,687,244 | high index mobil predict poor mobil cd cell anti lymphoma salvag chemotherapi perform stem cell collect mobil chemotherapi well balanc strategi anti tumor effect effici collect cd cell deep prolong nadir expos patient risk febril neutropenia febril neutropenia known associ lower yield cd cell quantit data refer associ yield cd cell sever neutropenia lack hypothes index develop quantit evalu sever neutropenia especi field hematolog malign could predict yield cd cell | D001781 | T061 |
34,687,243 | new method multipl test permut infer general linear model permut method common use test signific regressor interest general linear model glms function imag data set particular neuroimag applic reli mild assumpt permut infer glms typic consist three part choos relev test statist comput pointwis permut test appli multipl test correct propos new multipl test method altern common use maximum valu test statist across imag new method improv power robust inhomogen test statist across domain method reli sort permut function test statist base pointwis rank measur still implement even larg data perform method demonstr design simul experi exampl brain imag data develop r packag get use comput propos procedur | D001921;D059906 | T023;T060 |
34,687,241 | quadrat exponenti pubert stop model valid analys human growth pattern develop novel growth refer human growth pattern import especi paediatr public health aim review provid overview human growth especi secular chang growth pubert growth | D001827;D011627 | T032;T039 |
34,687,240 | parent experi short term support use continu glucos monitor diyrtcgm qualit studi investig experi parent care young children type diabet type diabet use continu glucos monitor diyrtcgm support set | D003922;D007003 | T047 |
34,687,239 | chiropt properti anion neutral nickel ii bis dithiolen complex base methyl dimethyl dddt ligand racem enantiopur nickel ii bis dithiolen anion neutral complex base methyl dihydro dithiin dithiol dddt dimethyl dihydro dithiin dithiol dm dddt ligand experiment theoret investig special focus chiropt properti accord time depend densiti function theori td dft calcul strong near infrar absorpt band typic complex weak activ circular dichroism cd moreov opposit sign axial equatori conform due variat angl transit electr magnet dipol moment thus lead mutual cancel contribut absenc band experiment cd spectra influenc number stereogen center oxid state complex chiropt properti highlight solid state structur complex tma ni rac dddt tma tetramethylammonium determin singl crystal x ray diffract analysi show rather unusu cis arrang two dithiolen ligand methyl substitu adopt axial conform stabl one gas phase | D009532;D009942 | T109;T196;T123 |
34,687,238 | retin defocus myop wear dual focus zonal contact lens evalu refract impact dual focus df myopia control contact lens cls accommod young myopic adult | D003261;D009216 | T047;T074 |
34,687,237 | treatment mous cumulus oocyt complex l carnitin vitrif vitro matur affect matur embryon development rate parthenogenet activ techniqu oocyt vitrif remain challeng anim speci present studi aim evalu effect cumulus cell presenc l carnitin lc treatment vitrif select immatur oocyt brilliant cresyl blue bcb stain matur embryon development rate parthenogenet activ immatur oocyt obtain cbl femal mice ovari stain bcb bcb cumulus oocyt complex coc select random part coc denud cumulus cell denud oocyt dos coc dos treat without lc mgml vitrif vitro matur ivm procedur number non vitrifi coc also treat lc ivm process fresh group matur rate intracellular glutathion gsh content development compet oocyt also examin gsh level vitrifi doslc vitrifi cocslc group signific higher p untreat vitrifi warm coc dos matur rate blastocyst development rate reduc vitrif warm procedur compar fresh group vitrifi cocslc group show higher percentag matur oocyt abil develop blastocyst stage vitrifi warm dos group p data indic presenc cumulus cell around compet oocyt lc treatment vitrif ivm procedur could improv parthenogenet development compet vitrifi warm oocyt increas gsh level acceler oocyt matur | D002331;D058989 | T116;T121;T109;T127;T070 |
34,687,235 | foxl cw much ado someth recent studi suggest uniqu foxl cw mutat pathognomon adult granulosa cell tumour ovari tumour suppressor gene recent issu journal patholog detail studi pilsworth et al seek rebut proposit foxl cw mutat uniqu characteris adult granulosa cell tumour ovari lead reduc transcript level implic foxl tumour suppressor gene studi provid compel evid wild type mutant foxl transcript protein express equival level context recent studi one drawn conclus foxl cw gain function mutat whose impact mediat enhanc interact smad transcript factor complex patholog societi great britain ireland | D006106;D010051 | T191 |
34,687,234 | soil chemic qualiti assess spatial distribut pomelo orchard acid red soil hilli region china soil qualiti assess critic strategi determin optimum fertil intens pomelo product studi evalu soil qualiti status map spatial distribut soil sampl collect pomelo orchard pingh counti southern china analyz nine chemic paramet altitud indic | D005638;D012987 | T167;T002;T168 |
34,687,233 | effect ferment time ph qualiti black carrot juic ferment kefir cultur storag effect ferment time h ph qualiti ferment beverag fbs produc black carrot juic bcj monitor storag c week | D018552;D000070716 | T002;T168 |
34,687,232 | next generat sequenc genotyp associ studi reveal associ hla drb delay hypersensit penicillin nonimmedi delay allerg reaction penicillin common life threaten genet factor influenc reaction unknownpoor knownpoor understood assess genet predictor delay penicillin allergi cover hla loci | D004342;D006968;D006969 | T046 |
34,687,229 | first histor cement franc boulogn sur mer investig th centuri manufactur cement base monument boulogn sur mer area north franc one cradl french cement industri main one grenobl region due joseph vicat first cement work fast set roman portland cement famous franc use throughout entir countri main object studi give preliminari insight type binder use sinc current scatter data specif structur assess effici tradit analyt techniqu x ray diffract xrd optic om scan electron microscopi sem observ coupl ed analysi use differenti natur artifici cement | D017610;D003738 | T122;T197 |
34,687,228 | pilot studi efficaci motiv interview group alcohol use disord present pilot studi design measur feasibl efficaci motiv interview mi group franc use wagner ingersol method | D000437;D062405 | T048;T061 |
34,687,227 | inter intra observ agreement grade radiograph thoracolumbar spinous process healthi hors pre purchas examin wide variabl radiograph grade system thoracolumbar spinous process hors aim studi determin agreement grade differ paramet combin radiograph spinous process equin thoracolumbar spine scope pre purchas examin hypothes agreement variabl interpret radiograph difficult | D010808;D000083442 | T058;T017;T023;T060 |
34,687,225 | home base gait analysi exploratori endpoint multicent phase trial limb girdl muscular dystrophi type r facioscapulohumer muscular dystrophi limb girdl muscular dystrophi type b lgmdr facioscapulohumer muscular dystrophi fshd genet muscular dystrophi increas number potenti therapeut approach aim studi report data exploratori digit outcom extract wearabl magneto inerti sensor use non control environ ambul patient fshd lgmdr short term multicent clinic studi | D049288;D020391 | T047 |
34,687,224 | combin nerv conduct studi score best suit polyneuropathi diabet patient nerv conduct studi ncs wide use diagnos diabet polyneuropathi combin z score sever measur z compound may improv diagnost grade abnorm aim determin combin nerv measur best suit studi diabet polyneuropathi | D003920;D003929;D011115 | T047 |
34,687,223 | pfos facilit liver inflamm steatosi involv nlrp inflammasom mediat hepatocyt pyroptosi perfluorooctan sulfon pfos fluorin organ pollut substanti accumul mammalian liver tissu howev impact chronic pfos exposur liver diseas progress under molecular mechan remain elus herein first time reveal micromolar rang pfos exposur initi activ nlr pyrin domain contain nlrp inflammasom drive hepatocyt pyroptosi show mgkgday pfos exposur may exacerb liver inflamm steatosi high fat diet hfd fed mice concurr elev express nlrp caspas pfos exposur result viabil impair ldh releas brl rat liver cell concentr pfos exposur activ nlrp inflammasom lead consequ gsdmd cleavag il releas initi pyroptosi dose depend manner wherea treatment nlrp inhibitor mcc abrog effect moreov pretreat mm ros scaveng n acetyl l cystein nac amelior pfos induc nlrp inflammasom activ pyroptosi collect data highlight pivot role pyroptot death pfos mediat liver inflamm metabol disord | D058847;D000069292 | T043;T116;T123 |
34,687,222 | risk attenu amplif us opioid crisi evolut risk identif ultim public privat respons becom known collect opioid crisi import case studi risk manag due reach magnitud impact articl examin number signal relat opioid risk use social amplif risk framework sarf investig limit set public sector activ polici respons evalu whether sarf present effect len examin serious shortcom risk manag opioid use histori risk attenu recent evid risk amplif goal articl limit address good fit sarf descript tool consid whether sarf effect reveal import gap public risk manag respons opioid exampl similar situat societ risk problem appli sarf support suggest relationship risk signal inappropri attenu public respons generat use insight regulatori efficaci exampl public risk manag similar conclus inappropri public respons stem amplif factor less support case risk continu larg overal find sarf particular focus signal function risk inform perform best organiz aid studi histor inform rather predict tool determin inappropri risk manag respons | D000701;D017150 | T121;T098;T109;T064;T131 |
34,687,221 | conjoint multi metal ion iminodiacet acid monolith microfluid chip structur base protein pre fraction pdms base multichannel microfluid chip design fabric simpl approach use readili avail tool uv initi situ polymer poli hydroxi ethyl methacryl co di ethylen glycol diacryl co n n diallyl l tartardiamid eppendorf tube achiev within min polymer process success translat microfluid chip format without modif iminodiacet acid success immobil aldehyd function monolith via schiff base reaction confirm ft ir spectroscopi four transit metal ion co ii zn ii ni ii cu ii chelat individu four ida monolith microfluid chip conjoint metal ion monolith microfluid chip display high permeabl poros affin microfluid chip pre fraction four human plasma protein fibrinogen immunoglobulin transferrin human serum albumin base surfac expos histidin surfac topographi protein recoveri approxim bradford assay data achiev multimonolith microchip reusabl even three protein adsorpt desorpt cycl | D001798;D007098;D044085 | T116;T090;T123 |
34,687,220 | reinnerv measur motor unit size index associ preserv muscl strength amyotroph later sclerosi muscl reinnerv motor unit size index musix may provid insight reinnerv pattern diseas amyotroph later sclerosi al howev known whether musix detect clinic relev chang reinnerv muscl manifest chang musix respons reinnerv motor unit loss | D000690 | T047 |
34,687,219 | integr approach evalu patient asymptomat minim symptomat hyperckemia current straightforward guidelin clinic diagnost manag hyperckemia frequent nonspecif present muscl diseas therefor aim describ diagnost workflow evalu patient condit | D006009;D009135 | T047 |
34,687,218 | glucocorticoid modul synapt plastic human tempor cortex epilepsi patient chronic stress contribut memori impair memori impair common patient tempor lobe epilepsi serious affect life qualiti chronic stress recogn cofactor epilepsi also impair memori function furthermor increas cortisol level report epilepsi patient anim model suggest aggrav effect stress memori synapt plastic mediat via glucocorticoid aim studi therefor investig effect glucocorticoid receptor gr modul synapt plastic human cortex epilepsi patient | D004827;D004833 | T033;T047 |
34,687,217 | effect orphan histidin kinas clostridi sporul progress metabol solventogenesi sporul clostridia main respons adapt acid environ aceton butanol ethanol abe ferment hypothes five orphan histidin kinas hks includ cac cac cac cac cac determin cell fate sporul solventogenesi studi compar genom analysi reveal mutat cac appear contribut nonsporul featur atcc henc individu interact role five hks regul cell growth metabol sporul investig ferment result mutant differ hk express level suggest cac cac play critic role regul sporul acid butanol biosynthesi morpholog analysi reveal cac knockout abolish sporul stage wherea cac overexpress promot spore develop stage vii cac knockout initi block sporul stage ii indic progress sporul alter engin hks combinatori hks knockout interact effect two differ hks investig studi elucid regulatori role hks clostridi differenti demonstr hk engin effect use control sporul enhanc butanol biosynthesi | D001426;D046969;D000071677 | T116;T007;T126;T123 |
34,687,216 | obes paradox patient chronic total occlus coronari arteri obes associ metabol syndrom increas risk coronari arteri diseas advers cardiovascular event impact bodi mass index bmi long term outcom patient coronari chronic total occlus cto less clear | D015992 | T201 |
34,687,215 | systemat workflow studi domain contribut bispecif antibodi select multimod chromatographi articl systemat workflow formul implement understand select differ prefer bind patch bispecif monoclon antibodi mab parent mab three multimod cation exchang resin system workflow incorpor chromatograph screen parent mab fragment various ph follow surfac properti map protein footprint use coval label follow liquid chromatographi mass spectrometri analysi chromatographi screen multimod resin intact mab indic enhanc select compar singl mode interact system bispecif antibodi bsab elut two parent mab resin retent bispecif transit co elut one parent mab parent mab capto mmc investig contribut differ domain mab fragment evalu result indic interact like domin fab domain higher ph protein surfac properti map employ hypothes potenti prefer bind patch solvent expos region parent fab final protein footprint carri parent mab bsab bound unbound state ph identifi prefer bind patch result intact mab analysi support hypothesi interact resin primarili driven residu fab fragment fc furthermor peptid map data indic light chain may play import role higher bind parent compar parent b resin system final result bsab indic halv molecul contribut bind resin albeit subtl differ compar parent mab workflow present paper lay foundat systemat studi chromatograph select larg multidomain molecul provid insight improv biomanufactur expedit downstream bioprocess develop | D018033 | T129;T121;T116 |
34,687,214 | bimekizumab treatment moder sever plaqu psoriasi efficaci safeti pharmacokinet pharmacodynam transcriptom phase iia random doubl blind multicentr studi bimekizumab monoclon antibodi select inhibit interleukin il il f current investig treatment moder sever plaqu psoriasi mainten dose everi week well establish il inhibitor psoriasi | D011565;D059467 | T086;T047;T081 |
34,687,213 | vivo caenorhabd elegan model therapeut research human prion diseas human prion diseas fatal neurodegen disord includ sporad infecti genet form inherit creutzfeldt jakob diseas due ek mutat prion protein code gene common form genet prion diseas phenotyp resembl sporad creutzfeldt jakob diseas clinic patholog level median diseas durat month date avail treatment delay occurr slow progress human prion diseas exist vivo model allow high throughput approach may facilit discoveri compound target patholog assembl human prion protein effect neuron surviv generat genet model nematod caenorhabd elegan devoid homologu prion protein express human prion protein ek mutat mechanosensit neuron system express ek prion protein induc specif behaviour pattern neurodegener green fluoresc protein express mechanosensit neuron addit format intraneuron inclus associ accumul proteas resist form prion protein demonstr experiment system power tool investig efficaci anti prion compound prion induc neurodegener prion protein misfold well context human prion protein within librari compound approv human use cross blood brain barrier identifi five molecul activ aggreg ek prion protein neurodegener induc transgen anim model break technolog limit prion therapeut research provid key tool studi deleteri effect misfold prion protein well describ neuron system | D004195 | T050 |
34,687,210 | earli childhood epilepsi epidemiolog classif aetiolog socio econom determin epilepsi earli childhood frequent resist therapi often associ cognit behaviour comorbid aetiolog focus precis medicin notabl gene base therapi may prevent seizur comorbid epidemiolog data util modern diagnost techniqu includ whole genom sequenc neuroimag inform diagnost strategi therapeut trial present year multicentr prospect cohort studi involv children year age scotland present epilepsi use two independ sourc case identif clinic report eeg record review captur recaptur methodolog use improv accuraci incid estim socio demograph clinic detail obtain present month later children extens investig aetiolog whole genom sequenc offer patient drug resist epilepsi aetiolog could yet identifi multivari logist regress model use determin associ clinic featur aetiolog outcom three hundr nineti children recruit year adjust incid epilepsi present first year life per live birth confid interv ci socio econom gradient incid signific higher incid depriv quintil per live birth ci compar least depriv quintil per live birth ci odd ratio ci relationship depriv incid observ group without identifi aetiolog suggest popul live higher depriv area greater multifactori risk epilepsi aetiolog determin children epilepsi syndrom classifi thirti one per cent identifi genet caus epilepsi present novel data aetiolog spectrum common present epilepsi earli childhood twenti four month present children drug resist epilepsi dre global development delay gdd identif aetiolog strongest determin dre gdd aetiolog determin dre gdd young children epilepsi genet test priorit highest yield investig like inform precis therapi prognosi epilepsi earli childhood common previous report epilepsi undetermin aetiolog present frequent depriv communiti like reflect increas multifactori risk within popul | D012959 | T098;T078;T081;T080;T102 |
34,687,208 | matern intak folat pregnanc risk cerebr palsi moband cp cohort folat prevent neural tube defect may play role neurodevelopment disord | D019587 | T168;T061 |
34,687,207 | longitudin associ fiber veget fruit intak qualiti life fatigu colorect cancer survivor month posttreat increas colorect cancer crc survivor popul highlight need dietari recommend order enhanc health relat qualiti life hrqol allevi symptom fatigu chemotherapi induc peripher neuropathi cipn gastrointestin problem | D000073116;D015179;D010523 | T191;T047;T101;T201 |
34,687,206 | vitamin supplement fractur adult systemat umbrella review meta analys control trial grow number systemat reviewsmeta analys srmas vitamin calcium fractur prevent led contradictori guidelin | D019587 | T168;T061 |
34,687,205 | dnmta epigenet regul key microrna involv epitheli mesenchym transit prostat cancer epitheli mesenchym transit emt involv prostat cancer pca metastat progress plastic suggest epigenet implic deregul dna methyltransferas dnmts sever microrna mirna play relev role emt interplay clarifi yet studi provid evid dnmta interact sever mirna central role ex vivo emt pca model obtain via exposur pc cell condit media cancer associ fibroblast analysi alter mirna profil show mir famili mir ab mir c mir mir known modul key emt factor regul hyper methyl promot dnmta main isoform recruit onto mirna promot coupl increas hkmehkm andor decreas hkmehkm interest result reveal differenti express two dnmta isoform b ex vivo emt regulatori feedback loop mir dnmta promot sustain transit toward mesenchym phenotyp demonstr abil mir target dnmta utr modul express emt factor particular zeb survey prad tcga dataset show patient express emt like signatur inde character regul mirna diffus hyper methyl mir c mir ab promot final show mir also target dnmta although seem involv emt pca | D044127;D015972 | T045 |
34,687,204 | inequit distribut ftp market neighborhood characterist evid target market flavor tobacco product ftps disproportion use among young peopl racialethn minor popul howev studi examin retail distribut product market beyond menthol cigarett studi creat geograph base predict market ftps overal cigarett cigar e cigarett smokeless store across washington dc neighborhood examin neighborhood level demograph correl amount ftp non ftp market | D066300;D062789 | T131;T073;T109 |
34,687,202 | hypertroph granul wound treat silver nitrat stick topic steroid rate wound closur hypertroph granul hg abnorm granul tissu rais level surround intact skin thought delay wound heal effect treatment elimin hg could speed heal well studi two common treatment chemic cauteri silver nitrat use topic steroid midwestern burn wound clinic treatment employ qualiti improv project compar wound size reduct hg wound undergo two treatment modal retrospect chart review identifi hg wound treat year period compar wound size prior month treatment length width surfac area result present clinic staff year later qualiti assur project repeat initi audit found data patient treat silver nitrat cauteri patient treat hydrocortison cream median length width decreas mm silver nitrat cauteri treatment mm hydrocortison treatment p repeat audit year later found patient treat silver nitrat treat hydrocortison median length width decreas mm respect silver nitrat cauteri treatment mm hydrocortison treatment p conclus uncontrol review suggest faster heal hg wound treat hydrocortison compar treat silver nitrat cauteri confirm control random studi warrant | D002056;D012835 | T121;T037;T197 |
34,687,201 | virtual visit outpati burn care covid pandem burn injur patient must frequent travel long distanc region burn center creat burden famili impair clinic outcom recent feder polici respons coronavirus pandem relax major barrier conduct synchron videoconfer visit home howev efficaci benefit virtual visit relat person visit remain unclear burn patient accord clinic qualiti assur databas maintain coronavirus pandem virtual andor person visit comprehens adult pediatr burn center queri demograph burn sever visit qualiti distanc data total patient includ studi total outpati encount virtual person save associ averag virtual visit mile mean standard deviat travel minut drive cost foregon wage earn virtual visit technic issu experienc patient signific lower pediatr adult patient p studi first assess efficaci synchron videoconfer visit home set outpati burn care find demonstr major financi tempor benefit burn patient famili technic issu remain import barrier particular adult popul clear understand barrier may inform futur studi healthcar system payor move toward improv access burn care remot healthcar deliveri servic | D002056;D000086382;D017216 | T058;T047;T037;T067 |
34,687,200 | glut knockdown nucleus tractus solitarii allevi fructos induc hypertens rat sever studi suggest mechan wherebi excess fructos intak increas blood pressur bp glucos transport glut fructos transport express enterocyt involv nucleus tractus solitarius nts modul increas bp follow fructos intak remain unclear | D006973;D017552 | T023;T047 |
34,687,199 | vitamin biomark dietari refer intak develop children systemat review meta analysi circul hydroxyvitamin oh accept vitamin exposureintak biomark choic within recent dri exercis use vitamin relat biomark well function marker suggest may valu futur vitamin dri exercis faowho one young children | D009752;D064167 | T033;T170 |
34,687,198 | cotton phloem load apoplast use singl member nine member sucros transport gene famili phloem load transport fundament process alloc carbon sourc organ sink tissu cotton gossypium spp high sink demand cellulos fiber grow seed coat storag reserv develop embryo along demand new growth shoot root address cotton mobil resourc sourc leav sink organ provid insight process contribut fiber seed yield plasmodesmata frequenc companion cell flank parenchyma minor vein higher expect apoplast loader cotton close related tilia spp hint passiv load suc canon transport sugar leav constitut c label photoassimil activ transport c suc uptak coupl autoradiographi indic activ c suc accumul minor vein suggest suc load apoplast esculin fluoresc suc analog accumul minor vein nine sucros transport sut gene identifi per diploid genom ghsut l show appreci express matur leav silenc ghsut l yield phenotyp characterist block phloem transport furthermor ghsut l cdna stimul esculin c suc uptak yeast ghsut l promot caus uida glucuronidas report gene express minor vein phloem arabidopsi thaliana collect result argu apoplast phloem load mediat ghsut l domin mode phloem load cotton | D017360;D052585 | T002 |
34,687,197 | action mechan small microbi volatil compound plant microorgan communic plant exchang chemic signal throughout phytospher direct contact plant occur benefici microorgan emit plethora volatil compound promot plant growth photosynthesi well development metabol transcript proteom chang plant compound also induc system drought toler improv water nutrient acquisit recent studi shown capac restrict benefici microb also extend phytopathogen plant respons microbi volatil compound frequent associ volatil organ compound molecular mass rang da da howev microorgan also releas limit number volatil compound molecular mass less da react protein andor act signal molecul compound promot photosynthesi growth exogen appli low concentr recent evid shown small volatil compound import determin plant respons microbi volatil emiss howev regulatori mechan involv respons remain poor understood review summar current knowledg biochem molecular mechan involv plant growth develop metabol respons small microbi volatil compound | D040901;D055549 | T091;T109 |
34,687,196 | incorpor nurtur care earli childhood develop pre servic servic train earli childhood develop refer child develop concept till eight year life first day import guidelin nurtur earli childhood develop encourag attent good health nutrit opportun earli childhood learn respons care secur indian academi pediatr iap releas consensus statement earli childhood develop highlight role pediatrician lead communiti general parent particular understand nurtur earli childhood develop articl look current undergradu postgradu medic curricula india analyz address earli childhood develop base identifi lacuna propos suggest chang current curriculum ensur futur doctor general pediatrician particular prepar intend role promot nurtur care earli childhood develop | D002657;D010290 | T040;T039;T102;T099 |
34,687,195 | role pediatrician earli childhood nurtur care relat safeti secur five compon nurtur care earli childhood develop good health adequ nutrit respons parent earli opportun learn safeti secur essenti attain optim development potenti child enabl himher becom product adult safeti state protect hazard caus natur forc unintent human error wherea secur compris protect hazard result deliber harm action inim behavior unlik compon safeti secur least address health program india form laps safeti secur young children includ injuri neglect maltreat physic emot sexual abus magnitud difficult ascertain communiti mani mishap avoid simpli understand child develop take precaut environment modif issu relat safeti secur usual address routin offic practic pediatrician multipl role respons need util everi opportun discuss prevent promot health care parent convert immun day holist well child visit ideal strategi parent educ prevent avoid injuri inform keep children safe secur pediatrician recogn indic volit injuri neglect abus compet manag need awar child right legal protect measur well legal oblig network various agenc involv child welfar protect | D002649;D002669 | T058;T048 |
34,687,194 | provid servic indian children development delay disabl communiti rashtriya bal suraksha karyakram invest earli childhood develop ecd essenti progress nation rashtriya bal suraksha karyakram rbsk launch communiti level screen earli identif manag chronic diseas birth defect diseas defici development delay disabl birth year health care provid district hospit special newborn care unit district earli intervent center deic infant screen deliveri point home home base new born care packag pre schooler school age children evalu mobil health team use standard tool anganwadi center school respect referr manag higher center deic use evid base tran disciplinari collabor approach delaydis zero expens initi dissemin awar healthi famili practic promot ecd pregnanc first two year life includ booklet journey first day android app ayushman bhava ecd call center provid individu counsel relat queri laqshya program promot mother friend labour illustr mother child protect card assist development monitor till date rbsk develop two nodal collabor center kolkata centr train personnel deic mobil health team year cumul children year screen delay disabl identifi children manag appropri futur hold expans develop state art special center collabor research self sustain capac build multi disciplinari personnel | D002657;D012017 | T097;T039;T170;T058;T040 |
34,687,193 | provid servic children development difficulti delay disabl earli diagnosi intervent communiti level paper describ two program use recommend tier approach world health organ nurtur care framework ncf viz earli childhood champion ecc program child develop aid cda program deliv umme child develop center non government organ mumbai ecc program build capac communiti health worker chws employ communiti base organ urban semi urban rural area deliv respons caregiv earli learn compon ncf framework children univers servic risk disabl target indic servic cda program train chws becom disabl worker communiti rehabilit servic scarc nonexist ecc cda program integr ecd servic exist work establish chws communiti preliminari evid reach effect accept till date chws train ecc program reach children identifi development delay ecc program meet well recogn need train packag respons caregiv earli learn compon ncf framework | D002657;D003150 | T040;T039;T097;T102 |
34,687,192 | earli childhood develop paradigm shift development screen surveil parent intervent program larg proport children age five year attain expect development potenti belong low middl incom countri lmic strategi use identifi children high risk development delaydisord includ development screen surveil monitor suitabl criteria development screen tool lmic establish tool meet benchmark base author identifi two tool may consid suitabl indian context intern guid monitor child develop monitor child develop integr manag childhood ill context howev implement sustain univers development screen program use feasibl present circumst emerg evid parent intervent program signific impact outcom relat earli childhood develop ecd nurtur care framework encompass five strategi known enhanc ecd young children even presenc advers good health adequ nutrit respons caregiv opportun earli learn safeti secur articl discuss paradigm shift incorpor nurtur care base prevent support promot health care servic offic practic activ parent involv may prove better option posit long last quicker impact ecd | D002657;D010290 | T040;T039;T102;T099 |
34,687,191 | famili center care newborn pilot implement nation scale india famili center care fcc well evidenc approach recogn standard care newborn children approach promot mutual benefici partnership health profession infantyoung children famili provid opportun develop trust relat transpar care implement experi newborn intens care unit highlight three prerequisit success implement includ adequ infrastructur basic amen primari caregiv attitudin chang amongst healthcar provid accept parentsfamili partner care newborn activ involv primari caregiv babi care activ alongsid nurs healthcar provid play crucial role empow parent improv confid compet transit role primari caregiv discharg fcc contribut domain nurtur care relev newborn care pediatr care level scope expand antenat postnat period promot earli childhood develop nation scale progress address actual perceiv barrier implement requir context specif adapt best use opportun fund support avail nation health program | D017028;D010290 | T097;T102;T098;T099 |
34,687,190 | nurtur beyond womb earli intervent practic newborn care unit surviv small sick babi increas last two decad though cost increas burden neuro morbid earli intervent ei capitalis uniqu characterist neuroplast amelior effect insult develop brain fetal earli infanc period ei provid posit sensorimotor experi promot neuro behaviour matur great mitig advers outcom risk babi ei includ nurtur care deliv antenat period continu development support environ famili centr care small sick babi new born care unit continu year life although concept well understood practic still lack consist standard across unit | D018479;D011295 | T058;T065 |
34,687,189 | nurtur care intervent realiz develop potenti everi child pilot scale maharashtra unicef nurtur care framework ncf earli childhood develop provid roadmap action focus pregnanc first three year life emphas need invest capac build empower servic provid famili communiti creat conduc environ promot child develop describ experi implement nurtur care intervent begin pilot project maharashtra cover popul scale model call aarambh begin cater popul opportun avail within exist servic across multipl sector use integr child develop servic icd scheme health sector other util multipl approach promot ncf within famili home visit frontlin worker flws mother meet growth monitor promot session communiti base event key opportun joint train flws establish supervisor flws trainer interact train curriculum critic element identifi success model environ appreci flws supervisor help build confid help intervent | D057191;D002657 | T058;T039;T040 |
34,687,188 | strengthen psychosoci stimul manag children sever acut malnutrit experi nutrit rehabilit center sever acut malnutrit sam increas risk mortal also increas risk impair motor cognit psychosoci develop across globe children younger five year age risk achiev development potenti world health organ manag guidelin sam includ integr earli childhood develop ecd direct sensori psychosoci stimul structur play therapi medico nutrit care process despit manag still larg focus nutrit rehabilit intervent take backseat countri move toward home base manag uncompl sam children henc equal import strong ecd compon communiti base manag program strengthen support sensori psychosoci stimul structur play support facil communiti base care sam children help surviv also thrive transform background briefli describ experi pilot studi aim strengthen intervent support nutrit rehabilit center across india | D044342;D000067011 | T047 |
34,687,187 | promot earli childhood develop use mhealth learn implement experi haryana pregnanc earli year life year crucial import child surviv health growth develop improv care young children consid fundament achiev sustain develop goal support intervida intern non government organ implement care earli childhood develop carri surviv women children foundat villag haryana india addit implement evid base intervent mhealth phone messag sms phone call use complementari strategi intent promot self care increas coverag improv inter sector collabor one messag per day develop messag sms sent beneficiari provid facilit interact base learn consolid approach core theme help refin interact lot qualiti assur sampl use evalu sms receiv read practic caregiv care provid intervent block substanti higher control block remark improv nutrit wast howev reduct stunt modest intervent area compar two control block attribut implement strategi project includ complementari approach use mhealth applic sms phone communic continu relev sinc peopl need poor requir integr packag servic maxim crucial period improv equiti coverag | D055810;D017216 | T058;T062 |
34,687,186 | promot famili integr earli childhood develop first day urban slum delhi feasibl earli implement experi first day critic human develop children resid urban slum higher risk suboptim develop articl report feasibl earli implement experi child stimul direct counsel integr nutrit health servic communiti functionari delhi slum implement research cohort studi design two group intervent group includ pregnant women infant children second year comparison group without intervent includ recent deliv women children age month feedback communiti functionari parent children also obtain video hindi voiceov demonstr toolstoysprop calendar depict age appropri child stimul activ prepar packag health nutrit servic deliveri frontlin functionari functionari coach famili child stimul use audio visual messag use tablet demonstr toolstoysprop twice everi three month monitor feedback data servic deliveri collect data intervent cohort shall compar comparison group document impact anganwadi centr pregnant women infant children recruit intervent famili receiv intervent within week averag time taken minut initi feedback communiti functionari parent encourag integr child develop packag accept feasibl implement communiti functionari possibl integr exist program scale | D002657;D011204 | T040;T080;T039 |
34,687,185 | intersector action earli childhood develop india opportun challeng way forward nurtur care framework earli childhood develop ecd focus five essenti aspect holist develop child interrel insepar multidimension approach child develop depend contribut multipl sector requir whole govern approach india lack singl multisector framework ecd narrow account sector specif outcom overlap respons frontlin worker lack leadership coordin limit supervisori mechan result fragment servic deliveri recent year high level polit commit intersector action promot holist health better result development outcom possibl differ sector work close converg resourc sustain develop goal strateg action plan poshan abhiyaan aspir district program leverag opportun intersector action requir deliber consist effort toward align goal favor condit partnership leadership govern capac everi level | D002657;D007857 | T040;T039;T054;T078 |
34,687,184 | promot nurtur care earli childhood develop india public health system implement nurtur care framework ncf earli childhood develop ecd essenti multisector requir coordin amongst sector harmoni integr within exist contact opportun health sector paper discuss relat strength persist gap challeng way forward implement nurtur care ecd public health system vast network frontlin health worker health facil communiti home center base servic deliveri health well center locat close communiti potenti promot nurtur care persist gap includ limit capac health worker nurtur care domain lack communiti engag ecd weak referr linkag inabl reach vulner children miss opportun earli identif children risk earli intervent children development delay difficulti move forward incorpor nurtur care compon essenti servic packag enhanc compet health worker engag parent establish mechan track children risk development surveil train servic provid provid much need impetus ecd | D002657;D011634 | T040;T091;T039 |
34,687,183 | india polici program landscap earli childhood develop despit continu improv health nutrit relat child outcom india last decad sub optim development outcom still prevail due multipl risk factor overcom risk depend support polici environ implement across relev sector achiev univers coverag children famili especi risk alreadi affect development disordersdis sever nation polici articul multi dimension multisector vision achiev earli childhood develop ecd focus first day reach vulner children enact various act entitl children right nutrit safeti secur flagship program various ministri translat vision action various scheme provid servic five domain nurtur care public spend largest sourc fund ecd program corpor social respons emerg promis fund opportun ensur effect implement ecd develop share framework implement across sector establish robust govern mechan sustain financ strategi univers access recommend way forward | D002657;D019472 | T040;T039;T078 |
34,687,182 | nurtur care earli childhood develop global perspect guidanc develop full potenti children need receiv nurtur care mean start pregnanc rais stabl environ sensit health nutrit need protect threat opportun earli learn interact respons emot support development stimul nurtur care ensur foundat laid earli life individu surviv thrive yet least million children younger year worldwid risk reach development potenti major implic health educ product well along life cours primari health care servic provid platform univers support famili children entri point earli identif intervent famili children addit need healthcar provid includ pediatrician uniqu well place watch learn strength vulner famili child open dialogu child develop support caregiv provid children nurtur care evid show caregiv support provid compon nurtur care start pregnanc children better chanc unlock development potenti even face advers paper outlin nurtur care framework five strateg action guid multi sector polici intervent servic articul import role health sector play support young children develop earli year | D017028;D002657 | T098;T099;T097;T039;T040 |
34,687,181 | status earli childhood develop india reach countdown target earli childhood develop ecd provid build block futur educ achiev emot moral develop earli year life provid critic window opportun intervent expert across world emphas promot ecd prong nurtur care framework ncf sustain develop goal focuss optimum develop children india million popul children year magnitud problem huge focus ecd sinc launch integr child develop scheme icd mani nation polici program evolv sinc promot ecd inspit effort overal pictur earli childhood develop india still optim due multipl factor five compon nurtur care framework includ comprehens servic offer india focus area come converg ecd deliveri system singl portal provid equiti grassroot level coupl proper document may proceed toward goal better pace multipl stakehold govern public privat health care provid non govern organ profession bodi need work synergi enabl us reach goal | D002657 | T040;T039 |
34,687,178 | effect antipsychot serum lithium level white blood cell count lithium carbon use increas white blood cell count mean counteract leukopenia caus administr antipsychot drug evalu effect antipsychot leukocyt enhanc effect lithium compar white blood cell count serum lithium level lithium dosag patient receiv antipsychot lithium combin patient receiv lithium alon chlorpromazin equival valu use indic antipsychot dose lithium serum level measur hospit patient lithium dose combin group median mg signific higher group receiv lithium median mg p lithium dose combin group receiv mg chlorpromazin equival overdos median lithium dose mg combin group treat mg chlorpromazin equival high dose median lithium dose mg signific higher group treat antipsychot medic median lithium dose mg p signific differ white blood cell count serum lithium level larg varieti antipsychot drug use combin lithium various dose use difficult evalu effect lithium without antipsychot administr leukocyt count enhanc plan studi larger number patient sinc renal function could assess studi also focus renal function includ urin output | D014150;D007970 | T039;T047;T121 |
34,687,175 | impact nuclear factor erythroid relat factor hepatocellular carcinoma cancer metabol immun status examin phosphoryl nuclear factor erythroid relat factor p nrf express surgic resect primari hepatocellular carcinoma hcc investig associ p nrf express clinicopatholog featur patient outcom also evalu relationship among nrf cancer metabol program death ligand pd l express retrospect studi immunohistochem stain p nrf perform sampl patient underw hepat resect hcc tomographycomput tomographi use fluorin fluorodeoxyglucos perform hcc cell line nrf knockdown analyz array also analyz express pd l hypoxia induc factor hifa knockdown nrf overexpress hcc cell line sampl patient posit p nrf posit p nrf express signific associ high alpha fetoprotein afp express high rate poor differenti microscop intrahepat metastasi addit posit p nrf express independ predictor recurr free surviv overal surviv nrf regul glucos transport hexokinas pyruv kinas isoenzym lr phosphoglycer kinas express relat maximum standard uptak valu pd l protein express level increas hypoxia induc factor nrf overexpress hcc cell conclus larg cohort studi reveal p nrf express cancer cell associ clinic outcom hcc addit found nrf locat upstream cancer metabol tumor immun | D006528;D008113;D051267 | T191;T116;T123 |
34,687,172 | field efficaci trial trival vaccin contain porcin circovirus type b mycoplasma hyopneumonia three herd field trial design evalu efficaci new trival vaccin contain porcin circovirus type b pcvab mycoplasma hyopneumonia three independ locat | D018173;D017925;D045705;D013553;D014765 | T007;T047;T121;T129;T005 |
34,687,171 | ripk mediat cell death involv dux mediat toxic facioscapulohumer dystrophi facioscapulohumer dystrophi fshd caus mutat lead aberr express dux transcript factor muscl dux propos induc cell death involv differ death pathway still discuss possibl pro apoptot role dux propos fshd muscl character necrosi inflammatori infiltr non apoptot pathway may also involv | D020391 | T047 |
34,687,170 | clinic score predict mortal patient acut heart failur japanes registri clinic score consid physic social factor predict long term observ patient acut heart failur limit studi aim develop valid predict model patient acut heart failur time discharg | D000203;D006333 | T080;T047;T056;T046 |
34,687,168 | recov rebuild covid best way support medic radiat scienc student covid pandem lockdown period impact medic radiat scienc mrs student profession person editori provid commentari two paper generat discuss mrs student support challeng time highlight univers clinic depart support student tailor proactiv support build resili peer group supervis | D000086382;D013337 | T097;T047;T067 |
34,687,167 | novel hla allel hla identifi next generat sequenc russian individu hla differ hla one nucleotid substitut posit exon | D015234;D059014 | T129;T059;T063 |
34,687,165 | intercontinent collabor clinic trial children adolesc cancer systemat review acceler sinc pediatr cancer drug develop global enterpris sought provid overview landscap intercontinent clinic trial pediatr oncolog open last decad | D002986;D000076722;D007391 | T091;T062;T064 |
34,687,163 | character novel hla c allel two next generat sequenc method novel hla c allel character use two next generat sequenc technolog | D015236;D059014 | T129;T116;T063;T059 |
34,687,162 | kinocardiograph assess chang haemodynam load patient chronic heart failur reduc eject fraction kinocardiograph kcg unobtrus devic consist chest sensor record local thorac vibrat produc result cardiac contract eject blood great vessel seismocardiographi scg lower back sensor record micromov bodi reaction blood flow vasculatur ballistocardiographi bcg scg bcg signal translat integr cardiac kinet energi ik cardiac maximum power pmax might promis metric futur telemonitor purpos heart failur hf first step valid studi aim determin whether ik pmax respons exercis induc chang haemodynam load heart hf patient | D001450;D006333 | T047;T060;T046 |
34,687,158 | potenti hibiscus sabdariffa linn manag fgf resist diet induc obes rat via mir regul obes caus fgf resist affect brown thermogenesi process adipos tissu decreas receptor express influenc mir whose express increas obes fgf base therapi wide investig potenti activ hibiscus sabdariffa linn extract hse fgf resist unknown | D005346;D031584;D035683;D009765;D012376 | T116;T047;T002;T123;T114 |
34,687,157 | bone marrow mesenchym stem cell low dose bone morphogenet protein enhanc scaffold base spinal fusion porcin model high dose bone morphogenet protein bmp result seri complic spinal fusion previous establish polyelectrolyt complex pec carrier system reduc therapeut dose bmp rodent porcin spinal fusion model studi aim evalu safeti efficaci combin bone marrow mesenchym stem cell bmscs low dose bmp deliv pec bone regener porcin model anterior lumbar interbodi spinal fusion alif applic six yorkshir pig underw tri segment alif four group name bmscs g bmp pec n b g bmp pec n c bmscs n g bmp absorb collagen spong n fusion outcom evalu radiographi biomechan test histolog analysi week mean radiograph score week group respect ct scan biomechan evalu histolog analysi demonstr solid fusion success bone regener group contrast group show inferior qualiti slow rate fusion group fail fuse interbodi space obvious evid seroma format implant reject complic group result suggest combin bmscs low dose bmp pec could lower effect dose bmp use bone graft substitut larg anim alif model | D059630;D013123 | T025;T061 |
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