PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,687,155 | hla b novel hla b allel two exon mutat novel hla b allel character use two next generat sequenc technolog | D005805;D015235 | T129;T116;T028 |
34,687,154 | enhanc cellular migrat prolong chondrogen differenti decellular cartilag scaffold dynam cultur condit lesion aural nasal tracheal cartilag frequent reconstruct complex surgeri base harvest autolog cartilag locat rib cartilag tissu engin cte regard promis altern attain vital cartilag nevertheless cte near natur properti pose signific challeng research due complex reciproc interact cell extracellular matrix imit still fulli understood thus use custom made glass bioreactor enhanc cell migrat decellular porcin cartilag scaffold decm mimic physiolog condit decm seed human nasal chondrocyt hpch cultur glass reactor week examin histolog immunohistochem stain biochem analys real time pcr day migrat depth number migrat cell quantifi comput analysi compar static cultiv dynam cultur dc foster migrat hpch deeper tissu layer furthermor cultiv bioreactor enhanc differenti cell first day differenti diminish cours cultiv consid dc present bioreactor promis tool facilit cte help better understand complex physiolog process cartilag regener maintain differenti chondrocyt improv cellular migrat optim cultur condit import prerequisit futur clinic applic | D020219;D054457 | T042;T122 |
34,687,153 | effect nurs innov workshop enhanc nurs innov abil quasi experiment studi investig effect nurs innov workshop enhanc clinic nurs innov abil research abil tertiari hospit | D003405;D009726 | T097;T041;T078 |
34,687,151 | angiotensin receptor blocker potenti protect effect branch chain amino acid skelet muscl atrophi cirrhot rat studi investig combin effect angiotensin ii ii receptor blocker losartan branch chain amino acid bcaa skelet muscl atrophi rat cirrhosi steatohepat | D000597;D057911 | T116;T121;T123 |
34,687,149 | echocardiograph assess radial right ventricular function heart transplant recipi right ventricular rv allograft dysfunct present half heart transplant ht recipi non invas assess rv function set reject well describ outlin echocardiograph techniqu short axi fraction area chang saxfac evalu rv function ht popul correl grade patholog reject | D016027;D018497 | T046;T061 |
34,687,148 | influenc inhibit renal neural regener efficaci renal denerv chronic heart failur studi support occurr nerv regener renal arteri renal denerv rdn unclear whether inhibit reinnerv rdn benefici enhanc effect rdn chronic heart failur chf | D006333;D016277 | T047;T042;T046 |
34,687,147 | inhibit mevalon metabol statin augment immunoregulatori phenotyp vascular endotheli cell inhibit costimul cd cell statin famili therapeut wide use clinic cholesterol lower agent effect target intracellular mevalon product key mechan action studi perform full transcriptom rna sequenc qpcr evalu effect mevalon immunoregulatori phenotyp endotheli cell ec find mevalon depend gene regul includ reduct express multipl pro inflammatori gene includ tnfsf ox l tnfsf gitr l co incid induct immunoregulatori gene includ lgal galectin lgal galectin function assay pretreat ec simvastatin inhibit mevalon metabol result dose depend reduct costimul cdro cd cell prolifer well il ifn il product versus vehicl treat ec contrast pre treatment ec l mevalon combin simvastatin revers phenotyp function respons collect result indic relat mevalon metabol ec critic sustain ec depend mechan immun find broad relev repurpos statin therapeut augment immunoregul andor inhibit local tissu pro inflammatori cytokin product follow transplant | D019161 | T121;T109 |
34,687,145 | multiplex droplet singl cell sequenc mux seq normal transplant kidney mainten system homeostasi kidney requir coordin respons divers cell type use singl cell rna sequenc scrnaseq patient tissu sampl remain fraught difficulti cell isol puriti experiment bias abil character immun parenchym cell transplant reject invalu defin transplant patholog tissu avail restrict needl biopsi fragment herein present feasibl data multiplex approach droplet scrnaseq mux seq mux seq potenti minim experiment batch bias variat even small sampl input first proof concept studi approach explant tissu six normal two transplant recipi multipl earli post transplant reject episod lead nephrectomi due aggress antibodi mediat reject pool mux seq comput tool demuxlet appli demultiplex individu cell pool experi sampl also appli individu singl microfluid run singleplex correl result pool data sampl appli protocol demonstr data mux seq correl high singleplex pearson coeffici sequenc result abil identifi mani known novel kidney cell type includ differ infiltr immun cell trajectori analysi proxim tubul endotheli cell demonstr separ healthi injur kidney transplant explant suggest evolv stage cell specif differenti alloimmun injuri studi provid technic groundwork understand pathogenesi alloimmun injuri host tissu respons transplant reject normal human kidney provid protocol optim process precious low input human kidney biopsi tissu larger scale studi | D042783;D016030 | T025;T061 |
34,687,142 | replac eye tracker ongo studi comparison eye track data qualiti tobii pro tx tobii pro spectrum tobii pro tx popular eye tracker development eye track research yet longer manufactur tx break may replac data qualiti replac eye tracker may differ tx may affect experiment outcom measur problemat longitudin multi site studi research replac eye tracker studi therefor ask tx successor tobii pro spectrum compar term eye track data qualiti data qualiti operation precis accuraci data loss compar eye tracker three age group around month month year precis better gaze posit signal obtain spectrum comparison tx accuraci spectrum higher month old month old children three year old children accuraci similar across eye tracker gaze posit signal spectrum exhibit lower proport data loss durat data loss period tend shorter conclus spectrum produc gaze posit signal higher data qualiti especi younger infant implic data analysi discuss | D000068598;D000084542 | T080;T073;T060 |
34,687,141 | advantag nanofibr membran cultur primari rpe cell compar commerci scaffold dysfunct retin pigment epithelium rpe caus numer form retin degener rpe replac modern option save vision aim test result transplant cultur rpes biocompat membran | D057139;D012162 | T046;T073 |
34,687,138 | benefit mr radiotherapi treatment plan anal rectal cancer plan studi limit evid exist show benefit magnet reson mr radiotherapi treatment plan anal rectal cancer studi aim assess impact mr plan target volum tvs treatment plan dose organ risk oar anal rectal cancer versus comput tomographi ct pathway | D050397;D012004 | T191;T061 |
34,687,137 | repeat mri activ surveil natur histori prostat lesion upgrad rate assess upgrad rate patient activ surveil prostat cancer pca serial multiparametr magnet reson imag mpmri | D011467;D011471 | T191;T023 |
34,687,135 | shorten palmaz genesi xd stent longitudin compress pediatr patient pulmonari vein stenosi bench test case seri palmaz genesi xd stent cordi cardin health dublin oh ideal option stent vessel pediatr patient due abil dilat larg diamet accompani children somat growth unfortun length limit util pulmonari vein stent small children due risk protrus left atrium distal pulmonari vein branch describ stent shorten techniqu longitudin compress prior deploy may enhanc applic pediatr pulmonari vein stenosi | D011667;D000071078 | T047;T023 |
34,687,133 | haemobilia secondari arterio biliari fistula rare complic intra oper microwav ablat hepatocellular carcinoma rare case arterio biliari fistula haemobilia complic intra oper microwav ablat hepatocellular carcinoma year old woman cirrhosi | D001658;D006528;D017115;D006431;D008113 | T047;T191;T046;T061 |
34,687,132 | lncrna miat enhanc cerebr ischaemiareperfus injuri rat model via interact egln reduc ubiquitin mediat degrad long non code rna lncrna miat myocardi infarct associ transcript character function lncrna modul cerebr ischaemicreperfus ir injuri howev under mechan remain poor understood studi explor function partner miat primari rat neuron regul ir injuri spragu dawley rat use construct middl cerebr arteri occlus mcao model cerebr cortic neuron use vitro oxygen glucos deprivationreoxygen ogdr model result show miat interact egln rat cortic neuron miat overexpress knockdown alter egln transcript contrast miat overexpress increas egln stabil ir injuri via reduc ubiquitin mediat degrad egln substrat mdm ubiquitin e ligas mdm interact n termin egln mediat k link poli ubiquitin therebi facilit proteasom degrad miat knockdown enhanc interact reduc egln stabil miat overexpress enhanc infarct volum induc higher ratio neuron apoptosi egln knockdown signific revers injuri miat overexpress reduc oxid pentos phosphat pathway flux increas oxidizedreduc glutathion ratio effect abrog egln knockdown conclus miat might act stabil egln via reduc mdm mediat k poli ubiquitin miat egln axi exacerb ir injuri via alter redox homeostasi neuron | D005786 | T045 |
34,687,131 | character mode action analysi black soldier fli hermetia illucen larva deriv hemocyt grow import black soldier fli hermetia illucen sustain food product wast manag well scienc great demand understand immun system aris present first descript circul larval hemocyt special emphasi uptak microorgan distinguish hemocyt type histolog zymograph cytometr method set hemocyt bind lectin antibodi hemocyt h illucen identifi plasmatocyt crystal cell putat prohemocyt total hemocyt count thc determin method thc determin compar approxim hemocyt per microlit hemolymph present naiv anim hemocyt densiti decreas dramat short wound indic role hemocyt respons wound immun respons general determin relat abund hemocyt type differenti hemocyt count dhc reveal plasmatocyt high abund wherea prohemocyt crystal cell make small percentag circul cell plasmatocyt abund also profession phagocyt h illucen rapid engulf take bacteria vivo vitro indic potent cellular defens invad pathogen larger bioparticl yeast also remov circul phagocytosi slower bacteria first analysi potent cellular immun respons black soldier fli first toolbox help identifi hemocyt type present | D004175;D006434 | T025;T204 |
34,687,130 | treatment gamma glutamyl transferas predict develop hepatocellular carcinoma chronic hepat b patient gamma glutamyl transferas ggt predict chronic hepat c relat hepatocellular carcinoma hcc develop role risk hcc chronic hepat b chb patient treat nucleotidenucleosid analogu nas elus | D006528;D019694;D008113 | T191;T047 |
34,687,126 | influenc aphot haloclin euxinia organ biomark microbi communiti thalassohalin alkalin volcan crater lake studi microbi communiti associ organ biomark found thrive aphot euxin water modern stratifi ecosystem scarc compar undertaken euxin photic zone dziani dzaha mayott indian ocean tropic salin alkalin crater lake recent present modern analog proterozo ocean due thalassohalin classif water marin origin specif biogeochem characterist continu intens photosynthet product microbi miner keep water column perman aphot anox prevent develop euxin sulfid anox photic zone despit high sulfidesulf ratio presenc perman season haloclin studi molecular composit organ matter lake dziani dzaha investig compar microbi divers evalu rrna gene amplicon sequenc two contrast season raini vs dri influenc water column stratif depth profil organ biomark concentr chlorophyl lipid biomark bacteri archaeal otu abund appear strong depend presenc aphot haloclin euxinia otu abund reveal import specif haloalkaliphil bacteri archaeal assemblag phytoplankton biomass recycl biogeochem function lake suggest new haloalkalin non phototroph anaerob microbi precursor lipid biomark uncultur firmicut famili syntrophomonadacea clostridial bacteroidet mlj aquat group emerg abund chemotroph bacteri member anox euxin water probabl respons product short chain n alken wax ester diplopterol tetrahymanol haloclin depend euxinia also strong impact archaeal communiti domin woesearchaeota sulfid free water euxin water methanogen euryarchaeota methanomicrobia thermoplasmata wsa class domin like origin common hydrocarbon biomark methanogen phytan pentamethyl eicosen partial hydrogen squalen | D060106;D064307 | T001;T083;T032;T028;T070 |
34,687,125 | review ecolog awar anxieti action among youth parent qualit studi newspap narrat despit grow impact climat chang mental health studi date investig children teenag manag ecolog grief eco anxieti leverag environment action scope review analyz lay press narrat youth respond climat chang examin dynam minor adult around evolv climat crisi | D001007;D001008 | T048;T184;T041 |
34,687,122 | effect supervis therapeut exercis program musculoskelet health gait patient haemophilia pilot studi episod bleed patient haemophilia pwh associ haemophil arthropathi limit physic perform reduc qualiti life qol gait disord | D006467;D011788 | T047;T078 |
34,687,120 | relaps remit secondari progress multipl sclerosi patient differ decod other emot eye difficulti emot process social cognit identifi multipl sclerosi ms patient potenti impact adapt social environ aim explor neural correl emot recognit ms possibl differ relaps remit ms rrms secondari progress ms spms patient read mind eye test rmet | D009103;D020528;D020529 | T047 |
34,687,118 | cross section studi associ effort reward imbal psycholog distress among japanes dietitian studi aim clarifi dietitian effort reward imbal eri examin associ psycholog distress | D000079225;D012201 | T048;T041 |
34,687,117 | rare germlin variant childhood cancer patient suspect genet predisposit cancer identif cancer predispos germlin variant childhood cancer patient import therapeut decis diseas surveil risk assess patient potenti also famili member investig spectrum preval pathogen germlin variant select childhood cancer patient featur suggest genet predisposit cancer germlin dna subject exom sequenc filter variant gene interest includ known cancer predisposit gene cpgs enrich burden analysi compar rare deleteri germlin cpg variant patient cohort healthi age control popul subset predict deleteri variant novel candid cpgs investig examin match tumor sampl function impact axin variant analyz cultur cell twenti two pathogeniclik pathogen plp germlin variant detect cpgs identifi patient unclear associ diagnos cancer type observ patient carri plp cpg variant burden rare deleteri germlin variant autosom domin cpgs signific higher studi patient versus healthi age control novel axin frameshift variant serf may impact regul catenin level select childhood cancer patient germlin test base featur suggest under genet predisposit could help identifi carrier clinic relev germlin cpg variant streamlin integr germlin genom test pediatr oncolog clinic | D020022;D009369 | T032;T191 |
34,687,116 | nonlinear interact land carbon cycl feedback earth system model carbon cycl feedback often quantifi carbon concentr carbon climat feedback assumpt signific interact two feedback previous studi calcul strength interact two respons use simul model particip phase coupl model intercomparison project cmip found nonlinear interact contribut land atmospher carbon exchang averag larg intermodel variat nonlinear interact larg driven pattern net primari product npp shift heterotroph respir dampen overal posit interact npp photosynthet rate per unit leaf area alon adequ explain wide variat interact global npp simul cmip model plant respir process regul leaf area also import contributor interact domin factor induc carbon concentr carbon climat interact high variabl among model one domin factor nutrient limit use addit simul access esm includ nitrogen phosphorus limit found estim interact access esm without nutrient limit cover larg intermodel variat among cmip model remain larg unknown nutrient limit complic ecosystem respons simultan co fertil warm global scale model result point potenti import role nutrient especi phosphorus nonlinear interact yet studi need ecosystem respons concurr chang nutrient avail atmospher co concentr warm | D057486;D017753 | T044;T070;T082 |
34,687,114 | cross section longitudin associ park coverag green exposur neighbourhood median household incom children depress anxieti symptom internalis symptom disord often emerg childhood associ negat health outcom adulthood studi shown neighbourhood characterist eg socio econom composit greenspac exposur associ depress anxieti symptom adult howev research explor relationship longitudin children lack studi examin cross section longitudin associ neighbourhood characterist development trajectori internalis symptom children age mother children health match studi | D001007;D012111 | T082;T184;T056;T083;T041;T081;T048;T078;T033;T096 |
34,687,113 | autolog platelet rich fibrin adjunct non surgic periodont therapi follow clinic pilot studi aim evalu effect autolog platelet rich fibrin prf adjunct scale root plane srp moder periodont pocket split mouth studi involv site patient baselin paramet record follow complet full mouth srp test control site random select autolog prf place test site site serv control blind examin record clinic paramet baselin day day statist signific found baselin probe depth pd clinic attach level cal statist signific improv observ within test control group day compar baselin valu statist signific differ test site found term reduct pd clinic attach gain cag compar control site end studi period p valu split mouth pilot studi emphas statist signific improv pocket depth reduct cal gain prf use adjunct srp moder periodont pocket | D000073183 | T122 |
34,687,112 | hold let go view filial pieti among adult children live new zealand studi aim explor perspect adult children late life live care arrang age immigr parent live new zealand | D032721;D054242 | T098;T099 |
34,687,110 | relationship kazakh elder disabl sever inform care time far north western low incom area china mediat role caregiv health home base care qualiti elder disabl sever caregiv health could predict elder inform care time mechan degre disabl elder affect inform care time unclear | D017028;D006233 | T097;T101;T098;T099 |
34,687,108 | unplan admiss pediatr intens care general anesthesia seven year retrospect cohort studi tertiari children hospit thorough preoper risk assess plan key improv patient safeti periop period analysi unplan icu admiss general anesthesia valid measur patient safeti use qualiti initi recommend mani countri | D000768;D010343 | T058;T061 |
34,687,107 | refocus attent work memori represent follow interrupt evid frontal theta posterior alpha oscil interrupt lead deterior primari task perform appli research usual describ delay primari task resumpt essenti compon perform deficit investig approach use electrophysiolog correl focus attent within work memori process fundament switch differ task later work memori task frequent interrupt either high low demand arithmet task subsequ retrospect cue indic work memori item requir later report detriment effect interrupt primari task perform pronounc high demand interrupt retro cue present fronto central theta power hz lowest follow high demand interrupt posterior alpha power hz less suppress two interrupt condit effect might relat deficit attent control process follow retrospect cue furthermor introduc suppress posterior alpha power contralater rememb primari task stimuli interrupt phase tempor marker primari task resumpt especi cognit demand interrupt task effect seem overlap time process interrupt contribut primari task perform deficit | D001288;D008570 | T041 |
34,687,106 | acid toler sulfat tetrahedr cage anion coordin driven assembl supramolecular cage construct anion coordin driven assembl acda recent year shown uniqu host guest interact howev report cage made phosphat ion po anion rare explor show first time sulfat ion also abl form l tetrahedr motif tris bis urea ligand depend stoichiometri sulfat ion solut notabl sulfat cage display enhanc resist brnsted ph low aceton contain water lewi acid metal complex compar correspond phosphat cage thus could find applic acid proton metal environ requir | D056831;D013431 | T104;T121;T196;T197 |
34,687,105 | serum neuron specif enolas new tool seizur risk monitor status epilepticus need accur biomark monitor electroencephalographi eeg activ assess seizur risk patient acut brain injuri seizur recurr may lead cellular alter subsequ neurolog sequela whether neuron specif enolas nse beta sb brain injuri biomark reflect eeg activ help evalu seizur risk investig | D010751;D013226 | T116;T047;T126 |
34,687,104 | axon damag determin clinic disabl chronic inflammatori demyelin polyradiculoneuropathi cidp prospect cohort studi differ cidp subtyp diseas stage monitor patient chronic inflammatori demyelin polyradiculoneuropathi cidp challeng daili medic practic interrelationship clinic disabl cidp subtyp neuron degener still elus aim prospect cohort studi investig role differ electrophysiolog variabl cidp monitor | D020277 | T047 |
34,687,102 | spatiotempor control distribut combin therapeut solid tumor dualli modifi bacteria method capabl distribut antitumor therapeut uniform durabl throughout entir tumor would great signific maxim treatment efficaci proven extrem challeng bacteria mediat spatiotempor control distribut combin therapeut solid tumor report reprogram immun microenviron optim antitumor efficaci combin synthet biolog interfaci chemistri bacteria insid outsid concurr modifi express phototherm melanin attach immun checkpoint inhibitor surfac due natur bacteria colon hypoxia intratumor environ therapeut agent distribut homogen last tumor ex vivo human vivo mous studi spatiotempor control local melanin repeat generat moder yet uniform heat tumor upon light exposur broad treatment window combin similar local inhibitor elicit dual phototherm stimul checkpoint blockad mediat immun activ effect synergist reprogram immunosuppress tumor microenviron therapeut valu demonstr signific inhibit tumor growth prolong surviv mice subcutan orthotop murin model colon dualli modifi bacteria pave avenu spatiotempor control distribut therapeut drug solid tumor | D009369 | T191 |
34,687,099 | hot press sgem weight bias medicin various form bias exist medicin includ race gender age socioeconom status weight bias weight bias receiv much attent literatur form bias often discuss weight bias discuss regard physician patient bias patient physician articl summar studi perform mclean et al well podcast discuss social media commentari investig evalu presenc physician physician weight bias | D004635;D000079322 | T091;T054 |
34,687,097 | hippocamp subregion alter verbal fluenci earli stage type diabet mellitus grow evid indic type diabet mellitus tdm relat cognit dysfunct may develop earli stage diseas often accompani hippocamp structur alter current studi investig volum shape alter hippocampus subregion level patient tdm use high resolut brain structur imag obtain tdm patient less year diseas durat healthi individu volumetr shape analys perform also assess relationship tdm relat hippocamp structur alter perform verbal fluenci volumetr analysi total hippocamp volum smaller tdm group relat control group subregion level tdm patient show signific inward deform volum reduct right dentat gyrus cornu ammoni subregion compar healthi individu particular tdm patient lower perform verbal fluenci smaller right dentat gyrus volum relat higher perform find suggest hippocampus may undergo atrophi subregion level even earli stage tdm subregion specif atrophi may associ reduc perform verbal fluenci | D060825;D003924 | T048;T047 |
34,687,095 | abo incompat kidney transplant perspect deceas donor transplant induct strategi propens match analysi kidney transplant candid blood group incompat rough one three potenti live donor compar outcom abo incompat aboi kidney transplant match abo compat aboc live deceas donor transplant analyz differ induct regimen perform retrospect studi propens match compar patient death censor graft surviv aboi versus aboc live donor deceas donor kidney transplant nationwid registri till aboi compar center propens match aboc live donor deceas donor recipi match recipi age sex blood group pra patient surviv better compar deceas donor hazard ratio hr death hr non signific differ aboc live donor recipi hr rate graft failur higher compar aboc live donor transplant hr reject occur rituximab versus rituximabbasiliximab alemtuzumab treat recipi p aboi kidney transplant superior deceas donor transplant reject rate graft failur higher compar match aboc live donor transplant underscor need studi risk stratif induct therapi ntr wwwtrialregisternl | D016030 | T061 |
34,687,092 | perspect liver redox imbal toxicolog pharmacolog aspect under iron overload nonalcohol fatti liver diseas thyroid hormon action oxid stress imbal oxid antioxid favor oxid lead disrupt redox signal control andor molecular damag alter cellular function redox imbal may trigger differ respons depend antioxid potenti given cell level reactiv oxygennitrogen speci rosrn attain time exposur protect effect induc low rosrn level acut short term condit harm effect high rosrn exposur prolong situat relev condit under liver redox imbal includ iron overload associ ros product via fenton chemistri magnitud iron labil pool achiev low iron exposur induc protect effect relat nuclear factor b signal transduc activ transcript nuclear factor erythroid relat factor nrf activ upregul ferritin hepcidin acut phase respons antioxid compon wherea high iron exposur caus drastic oxid biomolecul mitochondri dysfunct cell death due necrosi apoptosi andor ferroptosi redox imbal nonalcohol fatti liver diseas nafld relat polyunsatur fatti acid deplet lipogen factor sterol regulatori element bind protein c upregul fatti acid oxid depend peroxisom prolifer activ receptor downregul low antioxid factor nrf insulin resist phenomenon exacerb nonalcohol steatohepat trigger inflammatori respons thyroid hormon administr determin liver precondit ischemia reperfus injuri due redox activ sever transcript factor amp activ protein kinas unfold protein respons autophagi high grade liver redox imbal occur sever iron overload adequ handl iron chelat howev under nafldnash current studi sever phase ii phase iii trial | D019190;D065626 | T047 |
34,687,091 | qualiti life assess core outcom set posit statement eadv task forc qualiti life patient orient outcom core outcom set coss agre standard collect outcom measur report clinic trial specif clinic condit tsekh aim posit paper european academi dermatolog venereolog eadv task forc qualiti life patient orient outcom identifi challeng patient orient outcom advantag develop coss within dermatolog qol research twelv eadv task forc multidisciplinari team member present total item advantag disadvantag particip consid cos benefici comparison differ studi treatment dermatolog diseas geograph locat ethnic conclus eadv task forc qualiti life patient orient outcom recogn primaci advantag cos deliber disadvantag cos relat develop process use cos | D014686 | T091 |
34,687,090 | sugar seek insect sourc divers bread make yeast enhanc attribut insect repres particular interest habitat search novel yeast valu industri insect associ yeast potenti trait relev modern food beverag product due insect yeast interact trait includ divers carbohydr metabol high sugar toler general stress toler consid potenti valu insect associ yeast specif context bake isol yeast strain speci hymenoptera unit state repres yeast speci genera screen abil ferment maltos sugar import bread product result identif strain candida lachancea pichia speci assess abil leaven dough strain produc bake loav compar commerci bake strain saccharomyc cerevisia strain also grown various sugar salt condit relev osmot challeng experienc manufactur process product sweet dough show mani yeast strain notabl strain lachancea speci grow similar higher rate popul size commerci baker yeast addit assess compar phenotyp genet insect associ cerevisia strain unabl ferment maltos identifi bake relev trait includ variat hog signal pathway divers carbohydr metabol result suggest non convent yeast high potenti bake general showcas success bioprospect insect identifi yeast relev industri use | D001939;D012441 | T004;T168 |
34,687,089 | norwegian father experi home visit program explor father experi norwegian home visit program prenat period first year postpartum | D002662;D064691 | T058;T097 |
34,687,088 | enhanc spatial resolut hyperpolar carbon mri human brain metabol use structur guidanc dynam nuclear polar emerg imag method allow noninvas investig tissu metabol howev relat low metabol spatial resolut achiev limit applic improv resolut could import implic techniqu | D000465;D008279 | T170;T059;T060 |
34,687,087 | farm level cost driver salmonid fish health inspect regulatori cost aquacultur farm shown magnitud warrant addit analysi driver farm level cost fish health inspect identifi studi nation survey data us salmonid farm greatest cost identifi relat primarili state fish health requir inspect test certifi fish free specif pathogen prior approv necessari permit sell andor transport anim fish health inspect cost includ laboratori test farm personnel time veterinari fee ship sampl laboratori laboratori test valu farm personnel time expens compon princip cost driver number test whether requir sampl farmwid lot identifi collector farmer primarili sold recreat market greater fish health cost farmer primarili sold food fish greater number speci size age class salmonid farm regulatori requir test speci size age class farm increas inspect cost increas total number test total valu fish sacrif ship cost consequ farm one speci one size age class annual farm level test less cost annual lot base test increas number test given year although report respond increas cost dramat turn profit farm unprofit even food fish farm smaller salmonid farm experienc disproportion greater inspect cost burden larger farm fish health inspect scenario one annual inspect suscept speci size age class show cost burden generat econom distress even smaller salmonid farm scenario model base survey data includ lot base survey multipl speci size age class result substanti greater fish health inspect cost led unprofit various farm size busi type studi result suggest implement comprehens aquacultur health program standard might allow risk pathogen base reduct total number inspect fish sampl maintain equival greater health status compar current method american fisheri societi fish health section blue book inspect method interpret appli inconsist across state general yield lot rather farm level health attest histori test result risk assess biosecur practic typic taken account cost effect altern fish health sampl test requir consid decis polici fish health regul | D005398;D012487 | T092;T013 |
34,687,086 | dynam c mr spectroscopi altern imag assess cerebr metabol use hyperpolar pyruv human studi investig time resolv c mr spectroscopi mrs altern imag assess pyruv metabol use hyperpolar hp c pyruv human brain | D008279;D019289 | T121;T109;T123;T170;T060;T059 |
34,687,085 | separ spin compart arteri spin label use delay altern nutat tailor excit dant puls valid studi use relaxometri applic arteri cerebr blood volum imag clarifi type spin compart arteri spin label asl elimin delay altern nutat tailor excit dant puls use relaxometri demonstr feasibl arteri cerebr blood volum cbv imag use dant asl combin simplifi two compart model | D000071937;D002560 | T032;T042;T033 |
34,687,084 | leukocyt cytokin variabl asymptomat pug genet risk necrot meningoenceph necrot meningoenceph nme aka pug dog enceph inflammatori brain condit associ advanc diseas initi present rapid progress poor respons convent immunomodulatori therapi | D004283;D008590 | T047 |
34,687,083 | stay leav public health nurs workforc retent north carolina state across countri experienc steadi declin public health nurs workforc includ north carolina nc | D064689 | T097 |
34,687,080 | sex context differ effect trauma comorbid alcohol use post traumat stress phenotyp activ drink rat alcohol use disord aud affect disord frequent comorbid share under mechan could target comprehens treatment post traumat stress disord ptsd high comorbid aud comprehens model overlap nascent recent character model comorbid aud ptsd like symptom wherein stress rat receiv inhibitori avoid ia relat footshock two occas follow two bottl choic bc voluntari alcohol drink stress rat receiv second footshock familiar fam ia box first footshock novel context nov singl chamber apparatus fam paradigm effect increas alcohol drink male nov paradigm femal abstin stress male display avoid like ptsd symptom femal show hyperarous like ptsd symptom rat model alter spontan action potenti independ gabaerg transmiss central amygdala cea brain region key alcohol depend stress relat signal howev ptsd suffer may alcohol experi prior trauma therefor modifi audptsd comorbid model provid week intermitt extend alcohol access footshock studi effect nov fam stress drink ptsd phenotyp nov stress suppress escal alcohol intak prefer seen male control stress effect seen drink femal addit nov male decreas action potenti independ presynapt gaba releas delay postsynapt gaba receptor kinet cea compar control fam male despit chang alcohol intak cea gaba signal stress rat show broad similar anxiogen like behavior previous comorbid model suggest decoupl ptsd symptom aud vulner anim collect result show import alcohol histori trauma context vulner comorbid audptsd like symptom | D000437;D013313 | T048 |
34,687,078 | explor nurs onlin perspect social network global pandem covid examin onlin interact social network perspect nurs actor covid convers twitter understand profess respond global pandem | D000086382;D009726;D061108 | T097;T047;T170;T067 |
34,687,077 | poor oral health anorexia older rehabilit patient investig associ anorexia comprehens oral health status older inpati | D044342;D009909 | T033;T047 |
34,687,076 | melatonin melatonin agonist metabol syndrom compon patient treat antipsychot systemat review meta analysi metabol side effect limit factor use antipsychot remain cornerston long term manag patient sever mental ill contrast evid possibl role melatonin melatonin agonist attenu antipsychot induc metabol abnorm | D014150;D001714;D008550;D024821;D012559 | T047;T121;T109;T039;T125;T048 |
34,687,074 | translat novel antiemet sub saharan africa use diffus innov framework studi indic inhal isopropyl alcohol iia effect superior ondansetron adult patient although quick act low cost assum remedi suitabl adopt set explor innov antiemet remedi studi unit state translat sub saharan africa clinichospit set use roger diffus innov framework | D000932 | T039;T121 |
34,687,073 | qsmxt robust mask artifact reduct quantit suscept map quantit suscept map qsm estim spatial distribut tissu magnet suscept phase gradient echo signal qsm algorithm requir signal mask delin region reliabl phase subsequ suscept estim exist mask techniqu use qsm limit introduc artifact exclud anatom detail reli paramet tune anatom prior narrow applic robust mask reconstruct procedur present overcom limit enabl autom qsm process moreov method integr within open sourc softwar framework qsmxt | D016477;D008279 | T170;T059;T068;T060 |
34,687,072 | clinic laboratori ultrasonograph find differenti low grade intestin cell lymphoma lymphoplasmacyt enter cat low grade intestin cell lymphoma lgitl common intestin neoplasm cat differenti lgitl lymphoplasmacyt enter lpe challeng clinic sign laboratori result diagnost imag find histolog immunohistochemistri clonal featur may overlap | D002371;D004751;D016399 | T191;T047 |
34,687,070 | sustain nurs home visit cultur linguist divers famili australian nurs perspect australia sustain nurs home visit snhv program design implement promot posit outcom mother young children experienc complex life challeng despit crucial role train public health nurs dearth research experi deliv program cultur linguist divers cald famili limit english profici lep | D006792;D009726 | T058;T097 |
34,687,069 | correl nois brain magnet reson elastographi magnet reson elastographi mre use phase contrast mri generat mechan properti map vivo brain imag tissu deform induc mechan vibrat mechan properti estim process mre suscept nois physiolog mechan sourc encod phase expect high correl correl nois yet character brain mre effect mechan properti estim comput use invers algorithm undetermin | D054459 | T060 |
34,687,068 | measur radiofrequ field induc temperatur variat brain mri exam motion compens mr thermometri field monitor mr thermometri mrt method motion field fluctuat compens propos measur non invas sub degre brain temperatur variat occur radiofrequ rf power deposit mr exam | D062125 | T060 |
34,687,066 | serum zinc level patient phlegmon marker sever infect potenti zinc supplement reduc risk recurr analyz serum zinc level patient phlegmon lesion mean serum zinc level gdl serum zinc level negat correl c reactiv protein crp level r white blood cell wbc count r also posit correl serum level albumin hemoglobin hematocrit r respect patient serum zinc level gdl higher crp level wbc count p p respect lower albumin hemoglobin hematocrit level p p p respect like hospit p month remain patient one develop minim lesion anoth two experienc recurr twice lesion month respect find indic patient phlegmon serum zinc level suitabl marker sever infect zinc supplement reduc risk recurr patient whose lesion relaps | D002481;D015032 | T046;T121;T196;T123 |
34,687,065 | self supervis ivim dwi paramet estim physic base forward model assess robust repeat intravoxel incoher motion model ivim paramet estim diffus weight mri abdomin organ constraint noisi diffus signal use novel neural network method | D000465;D038524 | T170;T060 |
34,687,064 | perfus mri use endogen deoxyhemoglobin contrast agent preliminari data demonstr feasibl map cerebr perfus metric bold mri modul pulmonari venous oxygen satur | D002560;D003287 | T130;T033;T042 |
34,687,063 | covid vaccin respons peopl multipl sclerosi purpos studi investig effect diseas modifi therapi immun respons sever acut respiratori syndrom coronavirus sar cov vaccin peopl multipl sclerosi ms | D016867 | T033 |
34,687,060 | vitro recoveri fix clot activ marker high function hepatocyt hemophilia b ipsc model pluripot stem cell deriv hepatocyt differenti monolay cultur known fetal adult hepatocyt characterist numer studi tend show immatur phenotyp might necessarili obstacl use transplant applic drug screen toxicolog studi bioartifici liver reliant hepatocyt function requir full differenti hepatocyt new technolog use improv differenti process recent year usual evalu measur albumin product cyp activ use complex product import activ coagul factor ix fix produc matur hepatocyt assess differenti hemophilia b hb patient induc pluripot stem cell ipsc monolay cultur organoid | D002836;D057026;D019164 | T025;T074;T047 |
34,687,059 | understand humanis teach nurs experi care mapuch patient mapuch minor group live small communiti southern chile due mani variabl poverti cultur factor suscept inequ educ healthcar | D009726;D013338;D016746 | T097;T091 |
34,687,058 | fructos bisphosphatas defici caus fatti liver diseas requir long term hepat follow liver diseas occur pediatr adult age often undetermin caus case probabl relat undiagnos inherit metabol disord hepat disord associ fructos bisphosphatas defici gluconeogenesi defect report literatur symptom main describ acut crise mani report mention hypoglycemia hyperlactatemia frequent forefront herein liver manifest patient affect fructos bisphosphatas defici describ correspond literatur review interest patient liver abnorm either follow hepatomegali n elev transaminas n bright liver n acut crise hepatomegali n elev transaminas n acut liver failur n bright liver n initi report describ case liver steatosi liver biopsi necessari confirm diagnosi enzymat studi clear pathophysiolog basi fatti liver diseas postul endoplasm reticulum stress de novo lipogenesi activ could key factor observ fbp knockout mice liver steatosi may expos patient sever long term liver complic hypoglycemia becom less frequent age adult patient longer monitor hepatologist sign fructos bisphosphatas defici may subtl miss childhood suggest fructos bisphosphatas defici consid etiolog hepat steatosi liver monitor protocol set patient lifelong follow | D005234;D015319;D007003 | T047 |
34,687,055 | weight least squar regress compet risk data semiparametr acceler failur time aft model linear relat logarithm failur time set covari leav error distribut unspecifi model wide investig surviv literatur due simpl interpret relationship linear model howev much less focus develop aft type linear regress method analyz compet risk data patient potenti experi one multipl failur caus articl propos simpl least squar ls linear regress model caus specif subdistribut function convent ls equat modifi account data incomplet compet risk propos estim shown consist asymptot normal consist estim varianc covari matrix extend propos methodolog risk predict analysi cluster compet risk scenario simul studi suggest propos method provid rapid valid statist infer predict applic method two oncolog dataset demonstr util routin clinic data analysi | D015233 | T170;T081 |
34,687,053 | impact sever niti thermal treat instrument system biomechan prepar curv root canal extract mandibular molar evalu shape abil sever heat treat nickel titanium system use prepar root canal moder sever curvatur extract mandibular molar micro comput tomographi consid variat kinemat design | D003786;D018915 | T061;T030 |
34,687,052 | effect interleukin level time hospitalis erectil function hospitalis patient covid evalu relationship erectil dysfunct ed il level male covid studi includ male patient age year hospitalis due covid intern index erectil function iief questionnair use assess erectil function iief questionnair administ month control visit discharg chang score baselin record patient divid three group accord iief score month group sever ed group moder ed group ed two group accord il level time admiss group il ngml group b il ngml chang iief score p signific greater group b group also signific differ il group group p correl analysi reveal moder correl il level chang iief score dimer level r p weak correl il level fsh r p present studi suggest elev il level male patient hospitalis due covid might relat risk develop ed | D000086382;D007172 | T047;T067 |
34,687,050 | shear stress induc cellular senesc blunt liver regener notch sirtuin pp axi mechan involv liver regener partial hepatectomi phx complic cellular senesc link age play pivot role wound repair howev regulatori effect cellular senesc liver regener fulli elucid | D016922;D008115;D051880 | T043;T192;T116;T042 |
34,687,049 | describ econom benefit cost nonstandard work hour scope review benefit nonstandard work hour includ increas product time number job sector emerg servic around clock work necessari critic societ oblig work outsid tradit daytim schedul associ mani occup safeti health hazard associ cost thus organiz polici level decis nonstandard work hour difficult base sever factor includ econom evalu howev lack systemat knowledg econom benefit cost associ schedul | D016272 | T091;T078 |
34,687,048 | dispar perceiv true outcom infant born week gestat decis make infant born week involv counsel parent surviv major disabl risk accur inform need parent make inform decis babi care | D007234;D008880 | T097;T033;T100;T091 |
34,687,046 | inhibit hypoxia induc mucin alter proteom composit human osteoblast produc extracellular matrix lead reduc osteogen angiogen potenti bone microenviron one hypox region human bodi experiment model hypoxia inhibit osteogen differenti mesenchym stromal cell mscs previous work reveal mucin muc dynam express osteogen differenti human mscs upregul hypoxia upon stimul c terminus muc ct proteolyt cleav translocas nucleus bind promot target gene therefor assess muc mediat effect hypoxia proteom composit human osteoblast deriv extracellular matric ecm character osteogen angiogen potenti produc ecm generat ecm osteogen differenti human msc cultur vitro oxygen without go muc ct inhibitor hypoxia upregul muc vascular endotheli growth factor connect tissu growth factor independ muc inhibit wherea go stabil hypoxia induc factor alpha hypoxia andor muc ct inhibit reduc osteogen differenti human msc amp activ protein kinasemtorcsk pathway dampen matrix miner hypoxia modul ecm transform growth factor betasmad phosphoryl nfb upregul cola cola cola ecm hypox osteoblast reduc msc prolifer acceler osteogen differenti wherea muc ct inhibit ecm counteract effect addit ecm generat muc ct inhibit reduc angiogen potenti independ oxygen concentr claim muc critic hypoxia mediat chang osteoblastogenesi alter proteom landscap ecm therebi also modul osteogen angiogen potenti | D010012;D040901 | T091;T042 |
34,687,045 | problem interperson problem marit qualiti research consist illustr impact person marit qualiti given inher dyadic natur relationship recent investig integr spous rate person account spous perspect ground contemporari integr interperson theori view person interperson len conceptu maladapt interperson function interperson problem present studi examin increment valid spous rate interperson problem beyond self report interperson problem predict marit qualiti within expand actor partner interdepend model apim | D007398;D008393 | T079;T055;T072;T033;T054;T081;T080;T062 |
34,687,044 | relationship cold acclim extracellular ice format winter thermonasti two rhododendron speci f hybrid thermonast leaf movement evergreen rhododendron speci use studi plant strategi winter photoprotect add current fundament understand behavior address follow question cold acclim ca state necessari thermonasti cold induc leaf movement also occur non acclim na plant two movement leaf roll versus curl respons freez non thermonast speci tempor relationship extracellular freez thermonasti genet infer drawn leaf movement f hybrid relat parent | D029793 | T002 |
34,687,043 | interict brain activ chang tempor lobe epilepsi quantit electroencephalogram analysi evalu use quantit electroencephalographi qeeg analysi baselin activ patient tempor lobe epilepsi tle identifi measur potenti associ diseas durat drug resist | D004833 | T047 |
34,687,042 | character direct care health workforc unit state describ growth characterist direct care health workforc encompass home health aid person care aid nurs assist order psychiatr aid unit state | D000086382;D006280 | T081;T047;T067 |
34,687,041 | big five person trait perform quantit synthesi meta analys connect person trait perform fascin scholar varieti disciplin centuri present research synthes result meta analys k n examin associ big five trait overal perform | D010551 | T041 |
34,687,040 | quantit model simul framework support candid dose select anti sar cov monoclon antibodi advanc bamlanivimab first human clinic trial neutral monoclon antibodi mab novel therapeut treatment coronavirus diseas covid caus sever acut respiratori syndrom coronavirus sar cov urgent research start pandem select optim mab candid therapeut dose expedit use open access silico model maxim effect therapeut mab dose determin two approach expand innov open scienc initi physiolog base pharmacokinet pbpk model incorpor physicochem properti predict mab clearanc tissu distribut use estim mab exposur maintain concentr inhibitori concentr vitro neutral lung tissu week patient achiev fastest viral clearanc follow onset symptom longitudin sar cov viral dynam model appli estim viral clearanc function drug concentr dose pbpk model base approach suggest clinic dose mg bamlanivimab would maintain target mab concentr lung tissu day patient viral dynam model suggest mg dose would achiev maximum viral elimin taken togeth first human trial nct conserv proceed start therapeut dose mg escal higher dose evalu upper limit safeti toler avail open access code applic novel silico model base approach support select bamlanivimab identifi lowest dose evalu studi expect result maximum therapeut effect first human clinic trial | D008954 | T075 |
34,687,039 | mir suppress induc activ camppkacreb pathway requir camp induc bidirect differenti glioma cell factor increas camp level induc lineag specif differenti glioma cell astrocyt like cell howev differenti pattern under mechan remain unclear find campprotein kinas pka camp respons element bind protein creb induc mir suppress contribut neuron like differenti glioma camp agonist select induc neuron astrocyt like oligodendrocyt like differenti c glioma cell pka inhibitor creb knockout block neuron like differenti glioma cell camp inhibit mir pkacreb depend manner import vitro vivo assay demonstr transcript suppress mir requir neuron differenti glioma cell find suggest increas camp level induc bidirect differenti glioma cell furthermor mir cluster act epigenet brake glioma differenti | D002454 | T043 |
34,687,038 | differenti regul mir p delay wound heal melanocyt depriv vitiligo skin modul express tumor suppressor pdcd maspin loss melanocyt vitiligo associ architectur transcript cellular perturb keratinocyt manifest reduc prolifer potenti vitro delay epitheli vivo understand molecular mechan under delay microrna mirna profil perform split skin biopsi collect day basal level day wound epitheli nonlesion nl lesion l skin five subject stabl nonsegment vitiligo mirna found differenti regul nl l heal epidermi mir p express compar level nl l day sampl demonstr signific upregul epitheli howev extent upregul relat lower l time compar day compar nl skin time compar day overexpress mir keratinocyt led signific increas express prolifer marker ki mcm messeng rna ki posit along increas keratinocyt migrat use small interf rna mediat knockdown approach demonstr mir p mediat effect suppress express program cell death pdcd mammari serin proteas inhibitor maspin tumor suppressor gene investig clinic sampl corrobor lower mir level higher express pdcd maspin l day compar nl day epidermi conclus studi reveal relat lower upregul mir p l skin lead signific higher level pdcd maspin delay wound epitheli reduc prolifer migrat keratinocyt | D035683;D009369;D014820 | T191;T047;T114;T123 |
34,687,037 | obsess compuls disord children youth neurocognit function clinic communiti sampl neurocognit impair common ocd although well studi children youth disord | D009771 | T048 |
34,687,036 | efficaci high intens aerob exercis common multipl sclerosi symptom fatigu walk impair disabl symptom multipl sclerosi ms investig effect progress aerob exercis pae fatigu walk cardiorespiratori fit vo max qualiti life peopl ms pwms | D009103 | T047 |
34,687,035 | new insight nonaneurysm subarachnoid hemorrhag potenti role intern jugular vein caus nonaneurysm subarachnoid hemorrhag na sah still debat mani studi confirm possibl involv intracrani venous system particular variant basal vein rosenth | D013345 | T047;T046 |
34,687,034 | integr topic model network embed thread recommend thread common inform aggreg unit health forum effect thread recommend critic improv user experi onlin health communiti ohc paper propos ohc thread recommend method base topic model network embed recommend thread user train classifi predict user repli behavior | D012944;D012984 | T090;T170;T073;T054 |
34,687,033 | impact covid endoscopi germani practic hospit face great challeng cope covid pandem far data impact pandem gastroenterolog facil lack especi tempor cours databas lack especi outpati care sector univers hospit augsburg commiss generat data part collabor project b fast network univers medicin num | D000086382 | T047;T067 |
34,687,032 | appropri proton pump inhibitor ppi recommend discharg letter gastroenterolog depart proton pump inhibitor ppi one often prescrib drug worldwid thought great safeti profil advers effect case long term medic discuss recent undoubt use ppi base clear indic retrospect analysi investig number patient discharg gastroenterolog depart ppi medic also analyz recommend base establish indic dose durat therapi correct | D010351;D054328 | T058;T121 |
34,687,031 | reproduct life plan adolesc unplan pregnanc adolesc contribut burden diseas mortal health educ dispar experienc young peopl vulner period childhood adulthood reproduct life plan rlp approach endors adopt intern prompt individu coupl set person goal regard children base person prioriti review discuss rlp tool accept effect issu implement across differ context specif focus rlp appli adolesc rang rlp tool avail consid accept adult popul minim evid potenti benefit adolesc popul onlin platform inform technolog like promot reach implement rlp intervent adolesc consider socioecolog context adolesc pregnanc common integr much need futur work explor rlp intervent adolesc | D049168 | T033 |
34,687,030 | adolesc fertil preserv stand adolesc period flux mani bodi system fertil potenti typic increas menarch diseas opposit occur fertil preserv option need consid earli case cancer option vari pubert status includ ovarian tissu cryopreserv oocyt cryopreserv sperm cryopreserv testicular tissu cryopreserv much remain learn fertil preserv option differ sexual develop dsds howev depend form dsd fertil preserv may necessari similar tradit fertil counsel children galactosemia may need chang data suggest fertil rate attribut caus prematur ovarian insuffici may applic diseas adolesc turner syndrom high risk prematur ovarian failur therefor import consid option earli possibl sinc ovarian reserv deplet quick hand transgend gender divers adolesc may even abl undergo fertil preserv start hormon therapi case addit ethic compon includ technicalsurg risk childhood offer experiment therapi without creat fals hope evalu children consent assent capabl must consid | D059247;D008594;D016649 | T047;T061 |
34,687,029 | cytotox pouparton b alkyl cyclohexenon deriv poupartia borbonica human cancer cell line poupartia borbonica endem tree mascaren island belong anacardiacea famili leav plant phytochem studi previous isol alkyl cyclohexenon deriv pouparton c demonstr antiplasmodi antimalari activ addit high potenc plasmodium sp high toxic human cell also display present studi aim investig detail cytotox pharmacolog interest pouparton b one abund deriv leav p borbonica purpos real time live cell imag differ human cancer cell line normal fibroblast treat treat pouparton b perform potent inhibit cell prolifer associ induct cell death observ detail morpholog analysi differ adher cell line expos high concentr pouparton b gml demonstr compound induc array cellular alter includ rapid retract cellular protrus associ cell round massiv cytoplasm vacuol loss plasma membran integr plasma membran bubbl ultim lead paraptosi like cell death structur activ relat class compound select toxic pharmacolog potenti discuss | D027926;D010936 | T121;T002;T123 |
34,687,027 | softwar base evalu optim potenti clinic mri scanner radiolog aim studi use softwar applic analyz examin time changeov time two clinic high appli mri scanner univers hospit radiolog evalu whether could result optim potenti examin plan daili clinic routin mri diagnost | D008279;D011871 | T091;T170;T059;T060 |
34,687,024 | deliveri anti ifnar shrna hepat cell decreas ifnar gene express improv adenovir transduct transgen express chronic liver injuri lead advanc fibrosi cirrhosi hepatocellular carcinoma genet cell treatment relat use adenovirus ad proven benefici effici recoveri hepat diseas nevertheless high immunogen trigger immun respons interferon type ifn play import role three shrnas interferon receptor ifnar design clone pentru plasmid amplifi dh cell huh cell transfect plasmid presenc absenc viral particlesml adenovirus contain green fluoresc protein gene use report transfect shrna plasmid partial inhibit ifnar express inhibit substanti decreas antivir respons demonstr decreas ifnar ifn tnf gene express decreas protein level ifnar protein kinas rna activ pkr phosphoryl stat allow higher adenovir transduct transgen express interest seen shrna inhibit macrophag activ result suggest inhibit ifn pathway could strategi minim immun respons adenovir vector allow higher adenovirus transduct extend transgen express | D000256;D053633 | T192;T116;T005 |
34,687,023 | glycosyl antigen specif antibodi perspect immunoglobulin g glycosyl vaccin immunotherapi excit develop made understand antibodi mediat immun deepen understand antibodi effector function increas recogn critic mechan action beyond antigen recognit signific broaden evid base import effector mechan across divers infecti autoimmun diseas activ critic depend specif glycoform present conserv site igg fc domain relationship fc glycosyl profil antigen specif antibodi pool outcom infecti autoimmun diseas begun defin point key role posttransl modif biomark mechanist modifi antibodi mediat immun summar studi evalu profil activ antigen specif antibodi elicit infect vaccin well within context allo autoimmun consid current approach ration modif fc glycan vivo | D007141;D007074 | T129;T116;T121 |
34,687,022 | rapid expand nexus immunoglobulin g n glycom suboptim health status precis medicin immunoglobulin g preval glycoprotein whose downstream immun respons partial mediat n glycan within fragment crystallis domain collect term n glycom consid complex intermedi phenotyp amalgam genet predisposit environment exposur health behaviour life cours thus immunoglobulin g n glycom may provid indic health status spectrum health diseas infirmari although variabl exist within popul composit immunoglobulin g n glycom remain stabl short period time underscor potenti har immunoglobulin g n glycom ideal tool preclin diseas risk predict stratif prognosi develop precis dynam biomark | D054794;D007074 | T129;T121;T116;T090 |
34,687,021 | glycosyl plant produc immunoglobulin mani econom import protein base therapeut like monoclon antibodi glycosyl due recogn import type posttransl modif glycoengin express system obtain high activ homogen therapeut emerg field although monoclon antibodi market still produc mammalian express platform plant emerg altern cost effect scalabl product platform allow precis engin glycosyl produc target human glycoform larg homogen apart produc effect antibodi pure glycoform requir effort link biolog function specif glycan structur much alreadi known role igg glycosyl antibodi class domin recombin format express plant contrast littl attent paid glycoengin recombin igg subtyp four class human immunoglobulin iga igd ige igm except igd antibodi class express plant glycosyl analyz site specif manner summar current data glycosyl plant produc monoclon antibodi discuss find light known function glycan | D000911;D014026 | T129;T116;T002 |
34,687,020 | import monitor therapeut immunoglobulin g glycosyl complex diantennari type oligosaccharid asn residu igg heavi chain profound impact safeti efficaci therapeut igg monoclon antibodi mab fc glycosyl mab establish critic qualiti attribut cqa oligosaccharid profil requir thorough character state art analyt method fc oligosaccharid high heterogen differenti glycosyl speci glycoform igg express uniqu biolog activ glycoengin promis approach product select mab glycoform improv effector function non low fucosyl mab exhibit enhanc antibodi depend cellular cytotox activ approv clinic evalu treatment cancer autoimmunechron inflammatori diseas infect recent chemoenzymat glycoengin method allow transfer structur defin oligosaccharid asn link glcnac residu glycosynthas develop remodel igg fc oligosaccharid high effici flexibl addit various glycoengin method develop util fc oligosaccharid igg reaction handl conjug cytotox agent click chemistri provid new rout design antibodi drug conjug adc tight control drug antibodi ratio dar homogen review focus current understand biolog relev individu igg glycoform advanc develop next generat antibodi therapeut improv efficaci safeti glycoengin | D000911;D007074 | T129;T116;T121 |
34,687,019 | immunoglobulin glycosyl role diseas human iga compris two subclass iga iga monomer iga miga polymer iga piga secretori iga siga main molecular form iga product iga rival immunoglobulin isotyp larg quantiti iga reflect fundament role play immun defens protect vulner mucos surfac invad pathogen siga domin mucos surfac wherea iga circul predomin monomer form iga glycosyl glycan signific influenc various role includ antigen bind antibodi effector function mediat fab fc portion respect contrast protect role aberr glycosyl iga implic pathogenesi autoimmun diseas iga nephropathi igan iga vascul nephriti igavn furthermor detail character iga glycosyl includ divers rang heterogen emerg interest provid overview glycosyl observ subclass molecular form iga well rang heterogen site glycosyl mani way role iga glycosyl earli stage elucid chapter provid overview current knowledg research direct | D005922;D007070 | T129;T047;T116 |
34,687,018 | immunoglobulin g glycosyl diseas chang immunoglobulin g igg glycosyl pattern observ vast array auto alloimmun infecti cardiometabol malign diseas chapter contain updat catalog studi within igg glycosyl analysi perform diseas set sinc composit igg glycan known modul effector function suggest chang igg glycosyl pattern patient might involv diseas develop progress repres predisposit andor function effector diseas patholog contrast glycopattern bulk serum igg like relat system inflammatori background glycosyl profil antigen specif igg probabl play direct role diseas patholog sever infecti allo autoimmun antibodi depend diseas depend specif given diseas igg glycosyl read might therefor futur develop use clinic biomark supplementari current use biomark | D001327;D007074 | T129;T047;T121;T116 |
34,687,017 | sweet rule link glycosyl antibodi function antibodi produc upon infect pathogen microorgan essenti clear primari infect provid host long last immun moreov antibodi becom wide use platform develop novel therapi cancer autoimmun requir depth understand antibodi mediat activ vivo factor modul pro anti inflammatori antibodi activ sinc discoveri select residu present sugar domain attach immunoglobulin g igg fragment crystalliz fc region modul pro anti inflammatori effector function wealth studi focus understand igg glycosyl regul knowledg use optim therapeut antibodi activ introduct glycoengin afucosyl antibodi cancer therapi initi clinic test high sialyl anti inflammatori antibodi proof concept understand antibodi glycosyl lead clinic innov provid focus review summar recent insight antibodi glycosyl regul vivo select sugar residu impact igg function | D007141;D007074 | T129;T116;T121 |
34,687,016 | estrogen driven chang immunoglobulin g fc glycosyl glycosyl within immunoglobulin g igg fc region modul abil engag complement fc receptor afford opportun fine tune effector function mechan regul igg fc glycan remain poor understood chang accompani menarch menopaus pregnanc long implic hormon factor intervent studi confirm estrogen enhanc igg fc galactosyl femal also male defin first pathway modul fc glycan therebi new link sex immun mechan may particip fetal matern immun antibodi mediat inflamm aspect age sex specif immun function review chang affect igg fc glycom childhood old age evid establish role estrogen research direct uncov associ mechan may inform therapeut intervent | D007141;D007074 | T129;T116;T121 |
34,687,015 | immunoglobulin g glycosyl chang age inflammatori condit among multipl role play protein glycosyl fine regul biolog interact one import asparagin asn igg heavi chain decor diantennari glycan bear number galactos sialic acid residu branch rang addit structur present core link fucos andor bisect glcnac mani inflammatori autoimmun condit well metabol cardiovascular infecti neoplast diseas igg asn link glycan becom less sialyl less galactosyl lead increas express glycan termin glcnac condit alter also presenc core fucos bisect glcnac import similar glycom alter observ age common condit share mention patholog condit age low grade chronic asymptomat inflammatori state case age known inflammag glycom alter associ inflammatori diseas often preced diseas onset follow remiss aberr glycosyl igg glycan associ inflamm age sustain inflamm differ mechan fuel vicious loop includ complement activ fc receptor bind bind lectin receptor antigen present cell autoantibodi reactiv complex molecular base glycom chang associ inflamm age still poor understood | D001327;D007074 | T129;T047;T121;T116 |
34,687,014 | epigenet immunoglobulin g glycosyl altern glycosyl immunoglobulin g igg affect effector function immun respons igg glycosyl alter mani diseas also healthi life individu current limit knowledg factor alter igg glycosyl healthi state factor involv specif igg glycosyl pattern associ pathophysiolog genet background play import role epigenet mechan also contribut alter igg glycosyl pattern healthi life diseas known express mani glycosyltransferas regul dna methyl microrna mirna molecul involv epigenet mechan histon modif regul glycosyl relat gene glycogen still poor understood recent studi identifi sever differenti methyl loci associ igg glycosyl mechan involv format specif igg glycosyl pattern remain poor understood | D044127;D007074 | T129;T121;T116;T045 |
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