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34,686,882
format keto type ceramid palmoplantar keratoderma base biallel kdsr mutat patient function skin barrier requir sphingolipid homeostasi ketodihydrosphingosin reductas kdsr key enzym sphingolipid anabol catalyz reduct ketodihydrosphingosin sphinganin biallel mutat kdsr gene may caus erythrokeratoderma variabili et progress later specifi periopt syndrom emphas characterist periorif ptychotrop erythrokeratoderma report anoth patient compound heterozyg mutat kdsr born general harlequin ichthyosi progress palmoplantar keratoderma determin whether patient associ kdsr mutat lead kdsr substrat accumul andor unrecogn sphingolipid downstream product stratum corneum sc analyz lipid previous publish patient non ident biallel mutat kdsr sc patient identifi hitherto unobserv skin ceramid unusu keto type sphingoid base lesion non lesion area account measur ceramid speci furthermor overal shorter mean chain length free bound sphingoid base observ shorter mean chain length free sphingoid base also observ lesion psoriasi vulgari sc general lesion atop dermat sc format keto type ceramid probabl due bottl neck metabol flux kdsr bypass ceramid synthas highlight import tight intermedi regul sphingolipid anabol reveal substrat depriv potenti therapi
D003876;D007057;D007645
T047;T019
34,686,881
crk crkl share function neural crest cell cardiac outflow tract septat vascular smooth muscl differenti crk crkl encod cytoplasm adaptor contribut etiolog congenit heart diseas neural crest cell nccs requir cardiac outflow tract oft septat aortic arch format role crkcrkl nccs mous cardiovascular develop remain unknown test inactiv crk andor crkl nccs found loss crk rather crkl nccs result doubl outlet right ventricl loss crkcrkl nccs result sever defect earlier lethal due fail oft septat sever dilat pharyng arch arteri paa found defect due alter cell morpholog result reduc local nccs oft fail integr paa along reduc express integrin signal gene molecular studi identifi reduc differenti vascular smooth muscl cell may part due alter notch signal addit increas cellular stress lead modest increas apoptosi overal explain mechan crkcrkl phenotyp
D006330;D009432
T025;T018;T019
34,686,880
contin ileostomi short long term outcom forgotten procedur contin ileostomi ci aim provid control gas faecal evacu howev rare perform paper report outcom ci larg singl surgeon seri
D003093;D007081
T047;T061
34,686,879
organ preserv follow short cours radiotherapi rectal cancer non oper manag rectal cancer increas use select patient report includ patient treat chemoradiotherapi crt inclus watch wait w w programm aim studi report outcom singl centr w w programm involv larg cohort patient
D009926;D012004
T191;T061
34,686,878
incid detect outcom differenti thyroid cancer western sweden unclear whether increas incid thyroid cancer tc due increas diagnosi small indol tumour might mask real increas clinic signific cancer aim studi correl surgeri patholog outcom data individu patient mode primari detect palpat imag incident assess tc incid increas
D000230;D013964
T191
34,686,877
pathogen dyt thap dystonia mutat caus hypomyelin loss yy bind dystonia disabl diseas manifest prolong involuntari twist movement dyt thap inherit form isol dystonia caus mutat thap encod transcript factor thap pheleu fl missens mutat repres categori poor understood mutat occur residu critic dna bind demonstr fl mutat thapfl impair thap transcript activ disrupt cns myelin strike thapfl exhibit normal dna bind caus signific reduc dna bind yy transcript partner also establish role oligodendrocyt lineag progress result suggest model molecular pathogenesi wherebi thapfl normal bind dna unabl effici organ activ transcript complex
D004421;D004422;D020821
T048;T047;T184
34,686,875
impact initi site recurr prognosi curat surgeri primari lung cancer retrospect studi aim elucid impact initi site recurr relaps free surviv post recurr surviv prs curat resect primari lung cancer
D008175;D009364
T191
34,686,874
combin assess stress cardiovascular magnet reson angiographi predict effect revascular chronic coronari syndrom patient role revascular chronic coronari syndrom ccs valu ischaemia vs anatomi guid decis make constant debat explor potenti combin assess ischaem burden vasodil stress cardiovascular magnet reson cmr presenc multivessel diseas angiographi predict effect revascular caus mortal ccs
D003324;D019028
T047;T060
34,686,869
clinic practic guidelin manag colorect cancer consensus statement societi surgeon surgic oncolog societi pakistan joint effort societi surgeon pakistan societi surgic oncolog pakistan guidelin provid framework practic surgeon involv care manag patient colorect cancer guidelin take account issu relat local circumst provid minimum standard care must given patient guidelin committe member disciplin includ surgeri surgic oncolog medic oncolog radiat oncolog guidelin attempt simplifi thing understand follow practic surgeon guidelin wish elimin dispar treatment among institut prevent treatment patient
D015179;D066231;D000071077
T097;T091;T191
34,686,867
tumor induc reshuffl lipid composit endoplasm reticulum membran sustain macrophag surviv pro tumorigen activ tumor associ macrophag tam display pro tumorigen phenotyp support tumor progress respons microenvironment cue impos tumor stromal cell howev under mechan tumor cell instruct tam behavior remain elus uncov tumor cell deriv glucosylceramid stimul unconvent endoplasm reticulum er stress respons induc reshuffl lipid composit satur er membran macrophag induc ire mediat splice xbp product stat activ cooper splice xbp stat reinforc pro tumorigen phenotyp express immunosuppress gene ablat xbp express genet manipul amelior er stress respons facilit lpcat mediat incorpor unsatur lipid phosphatidylcholin hamper pro tumorigen phenotyp surviv tam togeth uncov unexpect role tumor cell produc lipid simultan orchestr macrophag polar surviv tumor via induct er stress respons reveal therapeut target sustain host antitumor immun
D059865;D008262
T049;T043
34,686,865
epitheli cell remov precancer cell cell competit via mhc class lilrb interact epitheli cell abil term cell competit immun surveil like function extrud precancer cell epitheli layer lead apoptosi clearanc howev remain unclear epitheli cell recogn extrud transform cell discov pirb famili protein leukocyt immunoglobulin like receptor b lilrb express non transform epitheli cell recogn major histocompat complex class mhc class high express transform cell mhc class interact lilrb express normal epitheli cell trigger shp rock pathway generat mechan forc extrud transform cell remov transform cell occur independ natur killer nk cell cd cytotox cell mediat activ new mechan immunolog ligand receptor system generat mechan forc non immun epitheli cell extrud precancer cell epitheli layer
D017209;D000084502
T043;T116;T123
34,686,862
dichotom metabol network govern human ilc prolifer function group innat lymphoid cell ilc repres innat homolog type helper cell h particip immun defens tissu homeostasi product type cytokin lymphocyt metabol adapt microenvironment chang knowledg human ilc metabol limit key regul unknown show circul naiv ilc unexpect metabol profil higher level oxid phosphoryl oxpho natur killer nk cell accord ilc sever reduc individu mitochondri diseas md impair oxpho metabolom nutrient receptor analysi reveal ilc uptak amino acid sustain oxpho steadi state follow activ interleukin il ilc becam high prolif reli glycolysi mammalian target rapamycin mtor produc il continu fuel oxpho amino acid maintain cellular fit prolifer result suggest prolifer function metabol uncoupl human ilc offer new strategi target ilc diseas set
D049109;D004734;D007113;D008213
T043;T032;T039;T040
34,686,860
mitochondri complex ii intestin epitheli cell regul cell mediat immunopatholog intestin epitheli cell iec damag cell contribut graft versus host diseas inflammatori bowel diseas immun checkpoint blockad mediat coliti littl known target cell intrins featur affect diseas sever identifi disrupt oxid phosphoryl increas succin level iec sever distinct vivo model cell mediat coliti metabol flux studi complement imag protein analys identifi disrupt iec intrins succin dehydrogenas sdha compon mitochondri complex ii caus metabol alter relev iec intrins sdha mediat diseas sever confirm complementari chemic genet experiment approach valid human clinic sampl data identifi critic role alter iec specif mitochondri complex ii compon sdha regul sever cell mediat intestin diseas
D003602
T043
34,686,858
kit base synthesi deoxi f fluoro sorbitol bacteri imag clinic avail imag tool diagnos infect reli structur chang affect tissu therefor lack specif differenti oncolog inflammatori infecti process develop deoxi f fluoro sorbitol f fds imag agent visual infect caus enterobacteral repres largest group bacteri pathogen human respons sever infect often result sepsi death clinic studi prospect enrol patient demonstr f fds positron emiss tomographi pet safe could detect local infect due drug suscept multi drug resist enterobacteral strain well differenti patholog steril inflamm cancer f fds clear almost exclus renal filtrat also shown potenti pet agent function renal imag sinc pet radionuclid short half life maxim clinic impact requir fast demand synthesi limit infrastructur personnel meet demand develop kit base solid phase method use commerci wide avail deoxi f fluoro glucos precursor allow f fds produc purifi one step room temperatur f fds kit consist solid phase extract cartridg pack solid support borohydrid mp borohydrid attach second cartridg reduc ph evalu effect differ solid support borohydrid reagent cartridg size start radioact volum flow rate radiochem yield puriti optim protocol complet radiochem puriti
D049268;D013012
T121;T060;T109
34,686,857
quantif organell contact site split gfp base contact site sensor splic live cell membran contact site organell essenti maintain cellular homeostasi requir continu exchang signal molecul ion nutrient lipid alter differ contact site associ wide spectrum human diseas howev visual quantifi contact site remain challeng protocol describ use split gfp base contact site sensor splic microscopi applic map organell contact site fix live cell splic sensor engin express equimolar amount organell target nonfluoresc gfp portion split gfp protein singl vector capabl reconstitut fluoresc two oppos membran come proxim reconstitut occur cell volum defin contact site result bright signal detect easili quantifi automat specif custom made plugin use minim target sequenc facilit target specif membran coverag avoid artifact due full length fusion protein overexpress thus possibl perturb cell physiolog splic sensor engin simultan detect multipl contact site within cell generat exploit abil gfp fragment reconstitut differ color shift variant gfp fragment describ detail protocol set splic express live cell detect acquisit autom quantif custom plugin also advis construct design character novel organell contact
D015388
T026
34,686,843
cardiac involv long term implic covid throughout medic scientif communiti focus manag acut morbid mortal caus coronavirus diseas covid pandem approv multipl vaccin light end dark tunnel opportun focus futur includ manag long term sequela patient surviv acut covid perspect articl highlight known cardiovascular sequela survivor covid discuss import question need address prospect studi understand mitig last cardiovascular consequ includ post acut covid syndrom provid greatest benefit survivor prospect studi begin resourc made avail monitor studi popul come year
D000086382
T047;T067
34,686,839
bilirubin repres negat regul ilc allerg airway inflamm group innat lymphoid cell ilc play import role allerg airway inflamm despit recent advanc defin molecular mechan control ilc develop function role endogen metabolit regul ilc remain poor understood herein demonstr bilirubin end product heme catabol potent negat regul ilc bilirubin metabol found signific induc airway inflamm mous model administr unconjug bilirubin ucb dramat suppress ilc respons interleukin il mice includ cell prolifer product effector cytokin furthermor ucb signific allevi ilc driven airway inflamm aggrav upon clearanc endogen ucb mechanist studi show effect bilirubin ilc associ downregul erk phosphoryl gata express clinic newborn hyperbilirubinemia display signific lower level ilc impair function suppress erk signal togeth find indic bilirubin serv endogen suppressor ilc might potenti therapeut valu treatment allerg airway inflamm
D001663;D008214;D012130
T121;T109;T123;T025;T046
34,686,835
nasoenter tube doppler guid insert case report review literatur nasoenter tube placement need patient gastric enter feed intoler high risk aspir sever techniqu describ ultrasound use common gastric tube placement also describ enter tube feed placement doppler techniqu cold water inject describ literatur describ new easi realiz techniqu case year old male patient intens care unit icu gastroparesi describ begin prokinet drug administ techniqu gastric tube placement bedsid assess ultrasound tube progress cold water inject duoden posit confirm doppler ultrasound ultrasound doppler techniqu nasoenter tube placement could feasibl techniqu use icu studi need assess effect techniqu
D004750;D007441
T074;T061
34,686,834
fetal lung develop via quantit biomark diffus mri histolog valid rhesus macaqu demonstr sensit diffus weight mri dw mri pulmonari cellular space chang normal utero develop use fetal rhesus macaqu compar histolog biomark
D038524;D047109
T039;T038;T060
34,686,819
medic devic legisl custom made devic uk left eu answer ten import question saw introduct three european direct aim harmonis medic devic legisl within european union eu given effect uk medic devic regul statutori instrument dental profession prescrib manufactur custom made devic requir accord relev requir one direct council direct eec medic devic direct mdd mdd replac regul eu medic devic regul eu mdr paper answer import question regard way affect provis custom made devic dental set
D062307
T089
34,686,818
develop implement feedback onlin special membership examin orthodont covid pandem introduct royal colleg surgeon england rcseng royal colleg physician surgeon glasgow rcpsg offer bi collegi membership orthodont morth examin summat assess specialist knowledg skill behaviour orthodont covid pandem profound global effect almost everi facet normal life includ conduct face face examin highlight develop implement feedback bi collegi morth part examin deliv remot cohort candid septemb rcsengrcpsgmethod two anonymis onlin survey googl form distribut via electron mail follow complet examin diet forti two candid sent survey cover four domain compris total question examin sent survey contain eight question survey free text respons also collect rate system use categoris respons survey respons summaris onlin data collect sheetresult respons rate candid examin respect overal favour respons relat section assess elicit candid major mean report onlin examin format work well equal favour respons report examin notabl examin felt onlin exam style affect mark candid would receiv confid mark candid receiv reflect abil affect onlin deliveri assessmentconclus feedback candid examin relat onlin remot assess bi collegi morth part general posit base survey respons format high stake examin accept stakehold demonstr high level perceiv valid reliabl term content
D000086382;D009970
T091;T047;T067
34,686,817
caus subcutan emphysema follow dental procedur systemat review case object caus subcutan emphysema se follow dental treatment chang new oper techniqu equip review demonstr frequenc aetiolog se inform prevent strategi reduc se occurrencesmethod systemat search medlin embas pubm databas identifi case se met inclus criteria independ review two author trend frequenc caus se display graphic signific differ frequenc se time period site hospit stay analys use testsresult dental extract often preced develop se case common surgic extract treatment posterior mandibular teeth often result develop se case iatrogen result air driven handpiec air syring factor nose blow account signific p increas case time mandibular teeth increas hospit stay time compar maxillari teeth p conclus increas risk se identifi follow use air driven handpiec dental extract treat lower molar teeth use air driven handpiec avoid dental extract reduc risk subsequ morbid result se
D013352;D014081
T046;T061
34,686,816
eros potenti common avail vape caus concern object relat littl known eros potenti vape product import consider dental health studi analys flavour vape potenti low ph includ fruit drink flavoursmethod ph purpos select vape measur undilut triplic serial dilut conduct eros product investig ifwhen eros potenti ph reach one eros sampl test undilut dilut four month open content analysi vape label determin ingredi place manufactur product usag instruct health warningsresult eighti four percent undilut vape sampl ph eros potenti predict flavour orang cola sampl higher anticip ph respect product predict non acid vanilla show consider variat rang ph fresh open store sampl reach non eros potenti ph even dilut repres concentr use vape label detail enough ascertain ingredi contribut acid buffer capac allow consum identifi least harm product term oral healthconclus present label commerci avail vape allow consum ascertain eros potenti possibl dental damag may inflict use effect label andor health warn requir educ consum dental health profession product
D014077;D000072137
T047;T055
34,686,815
adept studi compar studi dentist abil detect enamel proxim cari bitew radiograph without use assistd artifici intellig softwar introduct revers enamel proxim cari non invas treatment import prevent dentistri howev detect cari use bitew radiographi difficult subtl pattern often miss dental practitionersaim investig whether abil dentist detect enamel proxim cari enhanc use assistd artifici intellig ai softwaremateri method adept assistd enamel proxim cari assess studi dentist random divid control arm without ai assist experiment arm ai assist provid screen prompt indic potenti enamel proxim cari particip analys set bitew expert panel previous identifi enamel carious lesion healthi proxim surfacesresult control group found cari wherea experiment group found experiment group incorrect identifi cari healthi surfac compar control group increas sensit decreas specif statist signific p conclus assistd ai softwar signific improv dentist abil detect enamel proxim cari could consid tool support prevent dentistri general practic
D003731;D003733
T033;T047;T032
34,686,814
dental loss radiotherapi head neck cancer introduct radiotherapi rt head neck cancer hnc dental morbid signific may result loss dentit follow treatmentaim aim clinic studi identifi incid tooth loss time correl rt dose various risk factor patient hnc treat radic rtdesign retrospect observ studymateri method record patient hnc treat radic adjuv rt januari decemb analys appli strict inclus criteria patient individu tooth data select rt dose map perform toothresult total teeth extract follow risk factor signific gender p xerostomia p rt dose p smoke p non signific factor age rt deliveri techniqu addit cisplatinconclus detail rt dose map use identifi rt dose risk factor dental loss care pre rt dental treatment minimis rt dose teeth salivari gland requir prevent reduc loss dentit
D006258;D016388;D014987
T191;T047;T020
34,686,813
complianc problem dental infect prevent control england analysi care qualiti commiss inspect introduct dental practic england must regist care qualiti commiss cqc cqc inspect approxim practic year ensur premis safe complianc infect prevent control assess inspectionsaim aim studi identifi common area non complianc infect prevent control within general dental practic englandmateri method cqc inspect report practic found safe follow inspect themat analys non complianc specif infect prevent controlresult april march practic deem safe common area non complianc manag risk associ legionella audit valid decontamin equipmentdiscuss infect prevent control complianc requir good manag leadership factor also thought influenc complianc includ cost moralityconclus identif recurr infect prevent control complianc issu highlight relev area cqc dental registr merit greater focus
D011787
T058;T169
34,686,808
uk dental medicin advisori servic question ask dentist part drug use medic emerg dental practic uk dental medicin advisori servic ukdma provid advic dentist dental healthcar profession concern use medicin medic devic dentistri common ask question pose ukdma concern prescrib administ dental emerg drug dental practic discuss answer supplement relev inform clinician includ drug need stock emerg drug kit dental practic format storag restrict member dental team administ drug
D003815;D004364
T097;T121
34,686,807
complic factor complet dentur assess case complex articl aim describ common complic factor impact success complet dentur treatment present overview challeng pose practic author present rang medic oral social factor consid provid treatment edentul patient allow practition identifi case may requir referr inform applic dental practition use aid highlight complic factor individu patient make well inform clinic decis
D003815;D009066
T097;T033
34,686,806
prophylact extract extract partial erupt mesio angular impact lower third molar introduct prophylact remov mesio angular impact mandibular third molar maimm discourag nation institut health care excel consequ partial erupt maimm retain longer extract complic aris debat whether extract prophylact monitor teeth ongoingpatholog associ retain partial erupt maimm retain third molar long adulthood associ increas risk distal cervic cari extern root resorpt second molar periodont diseas pericoron among patholog although watch monitor help identifi patholog natur often lead poor prognosi third molar also second molar requir cost time consum restor even prosthodont workconsid prophylact extract individu risk assess paramount prophylact remov partial erupt maimm shown posit effect oral health relat qualiti life reliev pressur secondari care servic econom feasibl nhsconclus long term prospect cohort studi necessari put end ongo controversi patient need wish forefront provis care
D008964;D014095
T047;T023
34,686,777
accur detect quantif sar cov genom subgenom mrnas ddpcr meta transcriptom analysi sar cov replic requir synthesi set structur protein express discontinu transcript ten subgenom mrnas sgmrnas fine tune droplet digit pcr ddpcr assay accur detect quantifi sar cov genom orfab sgmrnas nucleocapsid n spike protein analyz rna sampl anonym sar cov posit subject observ recurr characterist pattern sgmrnas express relat total viral rna content addit express profil sgmrnas determin meta transcriptom sequenc subset rna sampl high correl obtain ddpcr provid comprehens dynam snapshot level sar cov sgmrnas infect individu result may contribut better understand dynam transcript express genom sar cov facilit develop accur molecular diagnost tool stratif covid patient
D000086462;D000086402;D064370;D059467
T116;T123;T005;T081;T086
34,686,776
induct invert morpholog brain organoid vertic mix bioreactor organoid technolog provid opportun generat brain like structur recapitul development step manner self organ examin vertic mix effect brain organoid structur use bioreactor establish invert brain organoid organoid generat vertic mix show neuron migrat outer peripheri inner core organoid contrast orbit mix comput analysi flow dynam clarifi comparison orbit mix vertic mix maintain high turbul energi around organoid continu kept inter organoid distanc dispers ad uniform rheolog forc organoid uncov mechan invert structur investig direct primari cilia cellular mechanosensor primari cilia neural progenitor vertic mix align multidirect manner orbit mix bidirect manner singl cell rna sequenc reveal neuron invert brain organoid present gabaerg charact ventral forebrain result suggest control fluid dynam biomechan engin direct stem cell differenti brain organoid invert brain organoid applic studi human brain develop disord futur
D019149;D002454
T043;T074
34,686,774
transcriptom uniqu cytokin microenviron castleman diseas castleman diseas cd repres group rare heterogen poor understood disord share characterist histopatholog featur unicentr cd ucd typic involv singl enlarg lymph node wherea multicentr cd mcd involv multipl lymph node station understand cellular basi cd undertook multi platform analysi use target rna sequenc rna situ hybrid ish adapt immun receptor rearrang airr profil archiv tissu ucd mcd non cd reactiv control ucd show differenti express upregul follicular dendrit cell marker cxcl clusterin angiogenesi factor lpl dll extracellular matrix remodel factor tgf skil loxl il adam cleca complement compon c cr germin center activ marker zdhhc blk compar control mcd show upregul il il st osmr lifr il plasma cell differenti xbp fdc marker cxcl clusterin fibroblast reticular cell cytokin ccl angiogenesi factor vegf mtorc pathway gene compar ucd control ish studi demonstr vegf increas follicular dendrit cell predomin atret follicl interfollicular macrophag mcd compar ucd control il express higher along interfollicular vasculatur associ cell mcd immun repertoir analysi reveal oligoclon expans cell popul mcd case ucd case consist antigen driven cell activ find highlight uniqu gene pathway cell type involv ucd mcd identifi potenti novel target cd may har therapeut
D005871
T047
34,686,772
aeciospor eject rust pathogen puccinia gramini driven moistur ingress fungi evolv array spore discharg dispers process develop theoret model explain eject mechan aeciospor liber stem rust pathogen puccinia gramini aeciospor releas cluster cup form berberi host spread earli season inoculum neighbor small grain crop model illustr dew rainfal chang aeciospor turgid exert substanti forc neighbor aeciospor cluster cup whilst gap spore becom perfus water perfus coat aeciospor lubric film facilit expuls singl aeciospor reach speed ms also use aeciospor sourc strength estim simul aeciospor dispers gradient incorpor public avail web interfac aid farmer legisl assess current local risk dispers facilit develop sophist epidemiolog model potenti curtail stem rust epidem origin berberi
D006813
T070
34,686,768
polygen score predict versus explan past decad polygen score becom fast grow area research behaviour scienc abil direct assess peopl genet propens transform research make possibl add genet predictor trait studi valu polygen score behaviour scienc rest use inherit dna differ predict birth common disord complex trait unrel individu popul predict power polygen score requir know anyth process lie gene behaviour also mandat disentangl extent predict due assort mate genotyp environ correl even popul stratif although bottom explan gene brain behaviour remain long term goal behaviour scienc predict also worthi achiev immedi practic util identifi individu risk necessari first step toward explan high prioriti research must increas predict power polygen score abl use earli warn system prevent problem
D055106;D020412
T032;T063;T045
34,686,767
mitochondri exosom mir coxa gamma synchroni biomark parvalbumin interneuron psychopatholog neurocognit schizophrenia earli detect intervent schizophrenia requir mechan base biomark captur neural circuitri dysfunct allow better patient stratif monitor diseas progress treatment prefront cortex blood redox dysregul mice gclm ko gbr oxid stress induc mir upregul lead decreas coxa mitophagi marker nix fundc lcb accumul damag mitochondria exacerb oxid stress parvalbumin interneuron pvi impair mitoq mitochondria target antioxid rescu process translat earli psychosi patient epp blood exosom mir increas coxa decreas combin mitophagi marker alter suggest observ made central peripher anim model reflect patient blood higher exosom mir lower coxa level associ reduct assr gamma oscil eeg assr requir proper pvi relat network alter mir coxa plasma exosom level may repres proxi marker pvi cortic microcircuit impair epp stratifi two subgroup patient group mitochondri dysfunct psi high mir low coxa level exosom b psi nd subgroup nolow mitochondri impair includ patient mir coxa level rang control psi patient exhibit impair assr respons associ wors psychopatholog status neurocognit perform global social function suggest impair pvi mitochondria lead sever diseas profil stratif would allow high select specif select patient treatment target brain mitochondria dysregul captur clinic function efficaci futur clinic trial
D035683;D012559
T048;T114;T123
34,686,766
molecular character depress trait state major depress disord mdd brain disord often character recurr episod remiss phase molecular correl mdd investig case control comparison biolog alter associ ill trait regardless clinic phase current state symptomat remit phase remain larg unknown limit target drug discoveri character mdd trait state depend chang singl recurr depress episod remiss generat transcriptom profil subgenu anterior cingul cortex postmortem subject first mdd episod n remiss singl episod n recurr episod n remiss recur episod n control subject n analyz data gene biolog pathway cell specif molecular level investig putat causal event therapeut lead mdd trait associ gene involv inflamm immun activ reduc bioenerget q wherea mdd state associ alter neuron structur reduc neurotransmiss q cell level deconvolut transcriptom data show signific chang densiti gabaerg interneuron posit corticotropin releas hormon somatostatin vasoact intestin peptid p probabilist bayesian network approach show causal role immun system activ q cytokin respons q oxid stress q across mdd phase gene set associ putat causal chang show invers associ transcriptom effect dopaminerg monoaminerg ligand studi provid first insight distinct cellular molecular patholog associ trait state mdd plastic mechan link two patholog method drug discoveri focus putat diseas caus pathway
D003865
T048
34,686,765
physic exercis rescu cocain evok synapt deficit motor cortex drug exposur impair cortic plastic motor learn under reduc behavior flexibl drug addict physic exercis use prevent relaps drug rehabilit program howev potenti benefit molecular mechan physic exercis drug evok motor cortic dysfunct unknown report week treadmil train restor cocain induc synapt deficit form improv vivo spine format synapt transmiss spontan activ cortic pyramid neuron well motor learn abil synapt behavior benefit reli de novo protein synthesi direct activ mechanist target rapamycin mtor ribosom protein pathway find establish synapt function restor mtor signal critic mechan support physic exercis train rehabilit addict brain
D003042;D009044
T023;T121;T109;T131;T029
34,686,764
alter function brain dynam chromosom q delet syndrom facial affect process chromosom q delet syndrom qds multisystem disord associ multipl congenit anomali variabl medic featur neurodevelopment differ result divers psychiatr phenotyp includ mark deficit facial memori social cognit neuroimag individu qds reveal differ relat match control bold fmri activ facial affect process task howev time vari interact brain area facial affect process yet studi bold fmri qds appli constrain princip compon analysi identifi tempor overlap brain activ pattern bold fmri data acquir emot identif task individu qds age race sex match healthi control delay frontal motor feedback signal diminish individu qds delay emot memori signal engag amygdala hippocampus entorhin cortex earli task relat engag motor visual cortic salienc relat insular activ relat preserv qds insular activ associ task perform within qds sampl differ cortic surfac area cortic thick show spatial align activ pattern associ face process find suggest relat match control primari visual process insular function relat intact individu qds motor feedback face process emot memori process affect insight may help inform potenti intervent target enhanc specif neuroimag indic cognit dysfunct qds
D004062
T047
34,686,763
fungal root endophyt serendipita vermifera display inter kingdom synergist benefici effect microbiota arabidopsi thaliana barley plant root associ bacteria confer protect pathogen infect contrast benefici effect root endophyt fungi synergist interact bacteria remain poor defin demonstr combin action fungal root endophyt widespread taxon core bacteri microbiota member provid synergist protect aggress soil born pathogen arabidopsi thaliana barley addit reveal earli inter kingdom growth promot benefit host microbiota composit depend use rna sequenc show benefici activ associ extens host transcript reprogram rather modul express microbi effector carbohydr activ enzym
D017360;D001467;D064307
T002;T001;T168;T032;T028
34,686,760
prokaryot respons warm temperatur anomali northeast subarct pacif water recent studi marin heat wave describ water temperatur anomali caus chang food web structur bloom dynam biodivers loss increas plant anim mortal howev littl inform avail water temperatur anomali impact prokaryot bacteria archaea inhabit ocean water nontrivi omiss given integr role drive major biogeochem flux influenc ocean product climat system present time resolv studi impact larg scale warm water surfac anomali northeast subarct pacif ocean colloqui known blob prokaryot communiti composit multivari statist analys identifi signific depth season depend trend accentu blob moreov network indic analys identifi shift specif prokaryot assemblag typic particl associ blob taxa consid free live chemoautotroph blob potenti implic primari product organ carbon convers export
D018407;D057231
T070
34,686,758
adroit accur robust method infer complex transcriptom composit bulk rna sequenc provid opportun understand biolog whole transcriptom level without prohibit cost singl cell profil advanc spatial transcriptom enabl dissect tissu organ function genom wide gene express howev readout technolog overal gene express across potenti mani cell type without direct provid inform cell type constitut although sever silico approach propos deconvolut rna seq data compos multipl cell type mani suffer deterior perform complex tissu present adroit accur robust method infer cell composit transcriptom data mix cell type adroit use gene express profil obtain singl cell rna sequenc refer employ adapt learn approach allevi sequenc techniqu differ singl cell bulk spatial transcriptom data enhanc cross platform readout compar systemat benchmark applic includ deconvolut complex mixtur encompass cell type demonstr prefer sensit specif compar mani exist method well util addit adroit comput effici run order magnitud faster method
D016678;D059467
T086;T028;T081
34,686,752
activ adipocyt crebcrtc pathway obes obes major risk factor develop type ii diabet increas adipos tissu mass trigger insulin resist via releas pro inflammatori cytokin adipocyt macrophag creb crtc coactiv found promot insulin resist obes although mechan unclear show high fat diet feed activ crebcrtc pathway adipocyt decreas express sik serthr kinas phosphoryl inhibit crtcs sik level regul adipogen factor cebp whose express reduc obes exposur ppar agonist rescu cebp express restor sik level crtc promot insulin resist via induct chemokin cxcl knockout crtc adipocyt reduc cxcl express improv insulin sensit administr cxcl revers salutari effect crtc deplet result demonstr import crebcrtc pathway modul adipos tissu function
D015398
T043;T044
34,686,689
characteris factor contribut perform nonwoven fibrous matric substrat adenovirus vector vaccin stabilis adenovirus vector offer platform technolog vaccin develop valu platform proven covid pandem although good stabil c advantag platform non cold chain distribut would substanti advantag particular low incom countri previous report novel potenti less expens thermostabilis approach use combin simpl sugar glass micro fibrous matrix achiev excel recoveri adenovirus vector vaccin storag temperatur high c matrix howev prone fragment suitabl clinic translat report investig altern fibrous matric might suitabl clinic use number commerci avail matric permit good protein recoveri qualiti sugar glass moistur content dri product achiev thermostabilis perform origin glass fibr matrix therefor investig physic chemic characterist glass fibr matrix compon find polyvinyl alcohol present glass fibr matrix assist vaccin stabil find enabl us identifi potenti biocompat matrix encourag perform discuss remain challeng transfer technolog clinic use includ reliabl process perform
D064166
T080;T081
34,686,688
global consist assess coastal eutroph eutroph emerg global issu associ increas anthropogen nutrient load impact extent eutroph often limit region dedic monitor programm introduc first global googl earth engin base interact assess tool coastal eutroph potenti cep tool evalu trend satellit deriv chlorophyl chl devis global map cep analys suggest global coastal water depth cover million km eutroph potenti also water associ chl increas trend eutroph potenti twofold higher show sign recoveri tool effect identifi area known eutroph sever symptom like dead zone well limit inform eutroph tool introduc prospect consist global assess eutroph trend major implic monitor sustain develop goal sdgs applic earth observ support sdgs
D005068;D012623
T167;T067
34,686,676
hedgehog artifici macrophag atom catalyt center combat drug resist bacteria pathogen drug resist bacteria repres threat human health instanc methicillin resist staphylococcus aureus mrsa ever grow need develop non antibiot strategi fight bacteria without trigger drug resist design hedgehog artifici macrophag atom catalyt center combat mrsa mimick captur kill process macrophag experiment studi theoret calcul reveal synthes materi effici captur kill mrsa hedgehog topographi substanti generat hclo fe n catalyt center synthes artifici macrophag exhibit low minim inhibit concentr gml fe art h combat mrsa rapid promot heal bacteria infect wound rabbit skin suggest applic hedgehog artifici macrophag captur kill capabl high ros catalyt activ open promis pathway develop antibacteri materi bionic non antibiot disinfect strategi
D008264
T025
34,686,668
human multi lineag hepat organoid model liver fibrosi investig pathogenesi congenit form hepat fibrosi human hepat organoid engin express common causat mutat autosom recess polycyst kidney diseas arpkd show hepat organoid develop key featur arpkd liver patholog abnorm bile duct fibrosi day arpkd mutat increas collagen abund thick collagen fiber product hepat organoid mirror arpkd liver tissu patholog transcriptom analys indic arpkd mutat generat cholangiocyt increas tgf pathway activ activ involv stimul myofibroblast form collagen fiber also expans collagen produc myofibroblast mark increas pdgfrb protein express activ stat signal pathway moreov transcriptom arpkd organoid myofibroblast resembl present common occur form liver fibrosi pdgfrb pathway involv confirm anti fibrot effect observ arpkd organoid treat pdgfrb inhibitor besid provid insight pathogenesi congenit possibl acquir form liver fibrosi arpkd organoid could also use test anti fibrot efficaci potenti anti fibrot therapi
D008954
T075
34,686,649
repetit transcrani magnet stimul rtms modul thyroid hormon level cognit recoveri stage stroke patient cognit dysfunct background singl center studi aim investig effect repetit transcrani magnet stimul rtms modul thyroid hormon level cognit recoveri stage patient cognit dysfunct follow stroke materi method seventi post stroke patient cognit impair random assign either rtms group control sham group group administ basic treatment rtms group receiv rtms hz mt puls min day day total time stimul site contralater dorsolater prefront cortex dlpfc sham group receiv sham stimul stimul paramet site except coil plane place perpendicular surfac scalp cognit function assess thyroid function test perform week treatment result serum level triiodothyronin free triiodothyronin ft thyroid stimul hormon tsh show posit correl montreal cognit assess moca scale score stroke patient recoveri phase post treatment chang score moca modifi barthel index mbi score cognit domain visuospati function memori attent well serum ft tsh level improv signific rtms group ft level signific affect moca score within refer rang conclus serum ft tsh level stroke patient recoveri phase posit correl moca score rtms increas ft tsh level also improv moca mbi patient recoveri phase stroke
D060825;D020521
T048;T047
34,686,648
success elbow flexion reconstruct use latissimus dorsi muscl transfer follow road traffic accid upper limb trauma background sever surgic procedur restor elbow flexion report literatur multipl factor direct select appropri procedur patient includ hand domin neurovascular injuri comorbid traumat damag anterior compart arm indic latissimus dorsi transfer restor elbow flexion bipolar pedicl latissimus dorsi ld flap design use rare simultan reconstruct bicep brachii soft tissu defect regain complet flexion function report case year old man underw success elbow flexion reconstruct use latissimus dorsi muscl transfer follow road traffic accid upper limb trauma case report year old man present acut compart syndrom caus road traffic accid impact trauma left arm surgic evalu reveal proxim bicep tendon raptur therefor immedi repair therapeut fasciotomi done subsequ unsuccess repair result total necrosi bicep muscl necessit debrid bicep muscl delay reconstruct ld flap success done stabil patient condit flap harvest free pedicl modifi tube like shape resembl bicep muscl conclus report shown surgic procedur latissimus dorsi muscl transfer success restor elbow function follow upper limb trauma howev preoper plan postop follow crucial function reconstruct upper extrem addit care select reconstruct surgeri consid patient factor degre injuri institut capac essenti factor achiev optim function restor minim complic
D016462;D019651;D064171
T023;T061
34,686,647
therapeut drug monitor anti infect drug implement strategi differ scenario therapeut drug monitor tdm support person treatment success implement tdm must turnaround time suit clinic need patient health care set author share view tdm strategi tailor specif set patient group
D000890;D016903
T058;T121;T061
34,686,644
herit musculoskelet pain pain sensit phenotyp generat rain studi need better understand biolog factor increas risk persist musculoskelet msk pain heighten pain sensit know herit gene account differ peopl trait enhanc understand genet vs environment influenc pain pain sensit howev gap current knowledg includ need intergener studi broaden understand genet basi pain data gen gen rain studi use investig herit msk pain pressur cold pain sensit particip includ parent gen n offspr gen n underw batteri test questionnair includ pressur cold pain threshold test assess physic activ sleep msk pain mental health adipos herit estim deriv use sequenti oligogen linkag analysi routin softwar herit estim msk pain pressur pain sensit signific account variat phenotyp contrast herit cold pain sensit signific largest intergener studi date comprehens investig herit msk pain pain sensit use robust statist analysi studi provid support herit msk pain pain sensit pressur suggest need converg genet environment factor model develop mainten pain disord
D059352;D017288
T033
34,686,642
post traumat stress disord childhood emot abus marker subthreshold bipolar wors treatment outcom major depress disord post traumat stress disord ptsd childhood maltreat cmt parent neglect emot physic sexual abus link bipolar disord also common major depress disord mdd object investig associ bipolar spectrum antidepress treatment outcom outpati dsm iv mdd treat combin medic enhanc depress outcom trial week bipolar spectrum score includ age onset year subthreshold hypomania period elat irrit mood least two concurr hypoman symptom fulfil dsm criteria hypomanicman episod depress mix state dmx ptsd subject n sever depress p work social impair p comorbid anxieti disord p increas suicid p bipolar spectrum score higher ptsd comorbid p childhood emot abus p ptsd comorbid associ residu suicid p week antidepress use wherea childhood emot abus odd ratio subthreshold hypomania dmx predictor mood switch result corrobor role ptsd childhood emot abus marker bipolar spectrum prognost factor antidepress treatment
D001714;D003865;D013313
T048
34,686,641
surgic techniqu adjuv manag pterygium provid updat review surgic techniqu adjuv manag pterygium
D011625
T047
34,686,640
prehospit end tidal carbon dioxid predict death massiv transfus injur patient eastern associ surgeri trauma multicent trial prehospit identif injur patient like requir emerg care remain challeng end tidal carbon dioxid etco use prehospit set monitor respiratori physiolog confirm endotrach tube placement low level etco demonstr correl injuri sever mortal number hospit studi hypothes prehospit etco valu would predict mortal need massiv transfus mt intub patient
D004632
T058;T093;T061
34,686,638
intrathorac rib plate fixat advantag extrathorac plate biomechan cadaver studi high morbid follow surgic intervent chest wall larg incis often prevent surgeon oper rib fractur treatment minim invas approach intrathorac side rib could allow smaller incis lower morbid maintain stabil fixat aim studi explor biomechan compet intrathorac versus extrathorac plate human cadaver rib fractur model investig effect plate use two versus three screw per fractur fragment
D001860
T074
34,686,637
use ultrasound acut set lesson learn year articl describ key event evolut surgeon use ultrasound evalu patient lesson learn may relev futur issu encount adopt ultrasound surgeon may revisit
D066231;D014463
T097;T060
34,686,635
differenti antimicrobi efficaci multipurpos solut acanthamoeba trophozoit investig examin effect sever common contact len solut disinfect acanthamoeba caus serious eye infect often result dysfunct improp use contact len product
D000048;D015823;D000890
T204;T047;T121
34,686,634
pain addict distribut suppli demand opioid epidem consider portion opioid epidem driven physician prescrib opioid pain manag thus polici address epidem must consid resourc avail manag addict manag acut chronic pain well period author sought describ distribut state indic suppli resourc address pain addict graduat medic educ subspecialti train pain addict number board certifi pain addict specialist number opioid treatment center well indic demand servic opioid prescript opioid overdos death identifi state seem suffer mismatch suppli demand also sought examin relationship treatment resourc indic magnitud opioid epidem exploratori correl analysi result model may inform public polici suggest area need greater graduat medic educ train pain addict specialist suggest hypothes impact specialist outcom worthi studi
D059350;D009293
T048;T047;T184
34,686,633
associ rule mine examin predictor outcom gait rehabilit program stroke survivor studi present novel applic associ rule data mine determin predictor respons locomotor train home exercis improv gait stroke studi secondari data analysi locomotor experi appli post stroke trial dataset associ rule analysi appli analyz three intervent earli locomotor train late locomotor train home exercis program outcom variabl whether particip poststrok greater median improv self select comfort gait speed three type predictor investig demograph behavior medic histori clinic assess baselin associ rule generat meet two criteria determin base data support confid identifi rule show predictor respons differ across three intervent inconsist previous report base tradit logist regress howev rule identifi high confid low support indic reliabl appear often locomotor experi appli post stroke trial dataset investig rule larger sampl size warrant appli clinic set
D020521;D000071939
T047;T061
34,686,632
effect robot assist gait train patient multipl sclerosi singl blind random control studi studi aim evalu compar effect convent robot assist gait train ragt program fatigu mood qualiti life patient multipl sclerosi fatigu
D020233;D009103;D012371
T033;T047;T184;T090
34,686,631
post acut covid syndrom negat impact physic function cognit function health relat qualiti life particip report describ persist symptom associ post acut covid syndrom pac impact symptom physic function cognit function health relat qualiti life particip
D000076604;D011788;D058992
T040;T032;T054;T078
34,686,630
discharg rehabilit measur predict activ limit patient stroke month inpati rehabilit aim studi identifi rehabilit measur discharg acut inpati stroke rehabilit predict activ limit mos postdischarg
D020521;D000071939
T047;T061
34,686,629
propriocept neuromuscular facilit improv symptom among older adult knee osteoarthr stair ascend random control trial studi aim investig effect wk propriocept neuromuscular facilit stretch pain propriocept joint rang motion joint moment stair ascend among older adult knee osteoarthr
D052580;D020370
T047;T061
34,686,628
discriminatori capac physic domain versus full scale pediatr qualiti life inventori traumat brain injuri sever children previous studi demonstr pediatr qualiti life inventori health relat qualiti life instrument consist physic psychosoci domain score reliabl differenti children vari sever traumat brain injuri n mos injuri howev pediatr qualiti life inventori physic domain score alon may simplifi evalu outcom physic rehabilit clinic research compar differ trauma intervent therefor perform secondari analysi evalu compar discrimin capac traumat brain injuri sever chang overal pediatr qualiti life inventori pediatr qualiti life inventori physic domain score alon use linear mix model assess chang outcom score baselin compar arm injuri control somer calcul compar discriminatori capac injuri sever predictor chang pediatr qualiti life inventori outcom score found traumat brain injuri sever children differenti pediatr qualiti life inventori physic domain score alon howev follow time point traumat brain injuri sever higher discriminatori capac chang overal pediatr qualiti life inventori result suggest overal pediatr qualiti life inventori use preferenti children traumat brain injuri although investig physic domain warrant condit physic injuri may predomin
D000070642;D011788
T037;T078
34,686,627
select ideal natur ligand tnbc inhibit cdc use bioinformat molecular biolog find potenti therapeut target tripl negat breast cancer tnbc patient bioinformat screen ideal natur ligand bind potenti target inhibit use molecular biolog
D064726
T191
34,686,626
comprehens analysi prognost gene gastric cancer gastric cancer associ high mortal effect method predict prognosi lack aim identifi potenti prognost marker associ develop gastric cancer bioinformat analys
D013274
T191
34,686,625
pattern predictor televis view comput use among women live socioeconom disadvantag neighborhood prospect cohort studi socioeconom disadvantag women increas risk sedentari behavior includ televis tv view comput use identifi determin behavior import
D057185;D012923;D013690
T079;T073;T098;T033;T080
34,686,624
effect blood flow restrict train muscl atrophi follow menisc repair chondral restor surgeri activ duti militari random control trial recent blood flow restrict bfr train gain popular altern high load resist train improv muscl strength hypertrophi previous bfr studi report posit treatment effect howev clinic benefit use bfr follow menisc repair chondral surgeri unknown purpos studi determin effect resist exercis bfr train versus exercis alon self report knee function thigh circumfer knee flexorextensor strength postmenisc cartilag surgeri
D000086382;D008889;D055070
T097;T047;T061;T067
34,686,623
occup leisur time physic activ differ relationship health cross section survey studi work nurs recent research focus potenti benefit physic activ occup set addit leisur time howev occup physic activ opa differ substanti occup requir heavi repetit physic work nurs explor associ leisur time opa health outcom work nurs midwiv
D015444;D007899
T061;T056;T078
34,686,622
relationship physic activ health relat qualiti life peopl dementia observ studi recent research suggest posit effect physic activ health relat qualiti life peopl dementia may mediat improv activ daili live reduc depress symptom one hundr twenti four peopl dementia inform carer recruit south east england observ studi subset particip wore acceleromet day seri bivari analys complet alongsid mediat analys peopl mild moder sever dementia weak posit associ wide report physic activ indic health relat qualiti life though singl associ reach statist signific rs p mediat analysi reveal signific indirect effect across model control cognit futur research need explor relationship greater emphasi modal psychosoci compon physic activ rather frequenc durat intens
D003704;D011788
T048;T078
34,686,621
kick like girl effect gender stereotyp motor skill learn young adolesc studi investig effect gender stereotyp soccer learn task base accuraci ie shoot differ size target among young adolesc b strategi use score mani point possibl perform baselin trial young adolesc random divid three group posit stereotyp negat stereotyp control perform five block trial two retent test day stereotyp manipul assess relat perman consequ stereotyp effect result show negat stereotyp induc particip perform wors acquisit phase first retent test posit stereotyp posit effect perform second retent test find provid first evid effect gender stereotyp motor learn task requir accuraci among young adolesc
D009048;D012916
T040;T056
34,686,620
effect activ precondit local system hypoxia submaxim cycl author compar effect activ precondit local system hypoxia submaxim cycl
D000860;D010101
T033;T046;T184;T201
34,686,619
manag train process elit sport descript prescript data analyt elit sport practition increas use data support train process decis relat athlet health perform care applic data analyt essenti gain valuabl insight recommend guid decis make busi organ data analyt develop base conceptu data analyt framework translat framework elit sport may benefit use data support train process decis purpos author aim present discuss conceptu data analyt framework base taxonomi use busi analyt literatur help develop data analyt within elit sport organ conclus present framework consist analyt step structur valu difficultycomplex descript step diagnost analyt step focus understand past train process predict step prescript analyt step provid guidanc plan futur although descript diagnost predict analyt generat insight inform decis prescript analyt use drive decis howev applic type advanc analyt still challeng elit sport thus current use data elit sport focus inform decis rather drive present conceptu framework may help practition develop analyt reason provid new insight guidanc may stimul futur collabor practition research analyt expert
D000077488;D013177
T056;T090
34,686,618
week fluctuat salivari hormon respons relationship load well semiprofession male basketbal player congest season phase assess week fluctuat hormon respons relationship load well congest season phase basketbal player
D001490;D064797
T061;T073;T056
34,686,617
case studi energi avail endocrin marker elit male track cyclist highlight energi avail status rest metabol rate measur dietari protein intak testosteron concentr elit male track cycl athlet mean sd age bodi mass kg height cm
D001481;D004044
T040;T116
34,686,616
singl serial carbohydr mouth rins improv yo yo intermitt recoveri test perform soccer player carbohydr cho mouth rins seem improv perform exercis last min howev effect intermitt exercis unclear also unknown whether serial cho mouth rins promot addit ergogen effect compar singl mouth rins aim studi evalu effect singl serial cho mouth rins yo yo intermitt recoveri test level yo yo ir perform soccer player random crossov doubl blind placebo control design male year soccer player perform eight serial mouth rins three differ condit placebo solut noncalor juic seven placebo mouth rins plus singl cho mouth rins maltodextrin eight cho mouth rins cho follow final mouth rins individu perform yo yo ir test evalu maxim aerob endur perform measur via total distanc cover differ yo yo ir perform session p singl cho mouth rins maltodextrin eight cho mouth rins placebo conclus singl serial cho mouth rins improv perform yo yo ir soccer player data suggest cho mouth rins effect ergogen strategi intermitt exercis perform irrespect number rins
D054874;D012916
T056;T055
34,686,615
critiqu nation physic activ polici oman use establish polici framework paper aim assess develop process content earli implement oman nation physic activ plan action identifi strength area improv
D015444;D000073296
T061;T047;T056
34,686,614
effect moder high intens inspiratori muscl strength train maxim inspiratori mouth pressur swim perform high train competit swimmer inspiratori muscl strength train imst improv exercis perform increas maxim inspiratori mouth pressur mip could benefici swimmer enhanc perform studi aim clarifi effect high intens imst week mip swim perform high train competit swimmer
D055070;D013550
T056;T061
34,686,613
week train load elit male ice hockey practic versus competit demand aim studi compar train load tl practic game across season microcycl elit danish male ice hockey
D006688
T056
34,686,612
habitu sleep pattern elit femal basketbal soccer athlet compar general popul compar habitu sleep femal basketbal soccer athlet age sex match control character sleep basketbal soccer athlet differ competit locat day surround competit
D001490;D012916
T073;T056
34,686,611
w balanc model mathemat methodolog consider sinc public w balanc model becom import tool scientif armamentarium understand predict human physiolog perform high intens intermitt exercis inde public featur model accumul adapt popular use desktop comput softwar wrist worn devic despit model intuit appeal achiev mix result thus far part due lack clariti basi calcul purpos review examin theoret basi assumpt calcul method strength limit integr differenti form w balanc model particular author emphas formul base distinct assumpt deplet reconstitut w intermitt exercis understand distinct form enabl practition correct implement model interpret result author discuss foundat issu affect valid util model follow evalu potenti modif suggest avenu research conclus w balanc model serv valuabl conceptu comput tool improv version may better predict perform advanc physiolog high intens intermitt exercis
D000072696;D010101
T061;T056;T201
34,686,607
conserv genet architectur among popul maiz progenitor teosint radic alter domest littl known domest constrain quantit genet architectur crop progenitor quantit genet architectur alter domest yang et al c j yang et al proc natl acad sci usa drew multipl conclus genet architectur influenc alter maiz domest base one sympatr pair teosint maiz popul test general conclus assay structur genet varianc genet correl among trait strength select domest divers genet architectur within teosint maiz result confirm addit genet varianc decreas domin genet varianc increas maiz domest genet correl moder conserv among trait teosint maiz genet varianc covari matric g matric teosint maiz quit differ primarili due chang submatrix reproduct trait infer long term select intens domest weak neutral hypothesi reject reproduct environment respons trait suggest target select domest g matrix teosint impos consider constraint select earli domest process constraint increas along domest trajectori final assay variat among popul observ genet architectur general conserv among popul within teosint maiz radic differ teosint maiz select drove chang essenti trait teosint maiz select explain littl differ domest trait among popul within teosint maiz
D017343
T028
34,686,606
roe inspir stem cell microcapsul inflammatori bowel diseas treatment mesenchym stem cell mscs exert regulatori effect various immun cell promis therapi inflammatori bowel diseas treatment howev therapeut effect limit lack nutrit suppli immun system attack low accumul target site inspir natur incub mechan roe present immun isol wet adhes nutrient rich microcapsul therapeut mscs encapsul adhes shell fabric ionic cross link algin visibl cure epsilon poli l lysin graft methacrylamid dopamin methacrylamid encapsul liquid core mscs roe protein due core shell construct result microcapsul mscs might escap attack immun system still maintain immunomodul function addit roe protein encapsul core phase offer suffici nutrient suppli mscs surviv prolifer furthermor intraperiton transplant wet adhes radic shell surfac could immobil mscs encapsul microcapsul onto bowel base featur practic valu roe inspir microcapsul mscs encapsul demonstr appli treat dextran sulfat sodium dss induc coliti increas resid time regul immun imbal reliev diseas progress believ propos roe inspir microcapsul mscs encapsul potenti clinic applic
D045164
T061
34,686,605
middl east respiratori syndrom coronavirus vaccin base propag defect rna replicon elicit steril immun mice self amplifi rna replicon promis platform vaccin generat defect one essenti function viral replic particl assembl dissemin make high safe vaccin previous show delet envelop e gene middl east respiratori syndrom coronavirus mer cov produc replic compet propag defect rna replicon mer cov e evalu replicon mice express human dipeptidyl peptidas virus receptor show singl delet e gene generat attenu mutant combin delet e gene accessori open read frame orf b result high attenu propag defect rna replicon mer cov ab e rna replicon induc steril immun mice challeng lethal dose virul mer cov histopatholog damag infecti virus detect lung challeng mice four mutant lack e gene genet stabl recombin e gene provid tran passag cell cultur show propag defect phenotyp vivo addit immun mer cov ab e induc signific level neutral antibodi indic mer cov rna replicon high safe promis vaccin candid
D012093
T114;T123
34,686,604
languag match model improv equiti effici covid contact trace contact trace pillar covid respons languag access equiti pose major obstacl covid disproportion affect minor communiti mani non english speak member languag discord increas process time hamper trust build necessari effect contact trace demonstr match predict patient languag contact tracer languag enhanc contact trace first show use machin learn combin inform spars laboratori report richer census data predict languag incom case second emb method high demand environ actual contact trace high volum case santa clara counti ca third evalu languag match intervent random control trial show low touch intervent result signific time save shorten time open case complet initi interview near h increas day complet improv engag reduc refus interview find import implic reduc social dispar covid improv equiti healthcar access broad level languag differ public servic
D007802;D000086402
T171;T005
34,686,603
tlr nod receptor signal skew monocyt fate decis via distinct mechan driven mtor mir monocyt rapid recruit inflam tissu differenti monocyt deriv macrophag mo mac dendrit cell mo dc infect site monocyt encount broad rang microbi motif pathogen recognit impact monocyt fate decis unclear show use vitro model allow simultan differenti human mo mac mo dc virus promot mo mac mycobacteria favor mo dc differenti mechanist found pathogen sens toll like receptor tlr ligand increas mo mac differenti via mtorc contrast nucleotid bind oligomer domain nod ligand favor mo dc induct tnf secret mir express confirm result vivo mous skin analyz transcriptom data human individu overal find allow better understand molecular control monocyt differenti monocyt plastic upon pathogen sens
D015398
T043;T044
34,686,601
tungsten enzym play role detoxifi food antimicrobi aldehyd human gut microbiom tungsten w metal general thought seldom use biolog show w contain oxidoreductas wor famili divers widespread microbi world surpris wor along tungstat specif transport tup abund human gut microbiom contain phylogenet distinct wor type two model gut microb contain six type wor tup shown assimil w two wor nativ purifi found contain w enzym catalyz convers toxic aldehyd correspond acid one wor carri electron bifurc reaction coupl aldehyd oxid simultan reduct nad redox protein ferredoxin aldehyd present cook food produc antimicrobi gut microbiom metabol aldehyd detoxif strategi depend avail w microb function wor gut microbiom oxid aldehyd remain unknown w general beyond detect part per billion common food picomolar concentr drink water suggest w avail could limit gut microbi function might overlook micronutri
D005502;D000069196
T001;T007;T168
34,686,595
peopl mistak internet knowledg peopl frequent search internet inform eight experi n provid evid peopl googl onlin inform fail accur distinguish knowledg store intern memori knowledg store extern internet relat use knowledg peopl use googl answer general knowledg question confid abil access extern inform also confid abil think rememb moreov use googl predict know futur without help internet erron belief indic misattribut prior knowledg highlight practic import consequ misattribut overconfid internet longer avail although human long reli extern knowledg misattribut onlin knowledg self may facilit swift seamless interfac intern thought extern inform character onlin search onlin search often faster intern memori search prevent peopl fulli recogn limit knowledg internet deliv inform seamless dovetail intern cognit process offer minim physic cue might draw attent contribut result peopl may lose sight knowledg end internet knowledg begin think googl may caus peopl mistak internet knowledg
D020407;D019359;D008568
T170;T041;T073
34,686,589
quinolin acid kynureninetryptophan pathway metabolit associ impair cognit test perform system lupus erythematosus interferon alpha import contributor sle pathogenesi induc enzym indoleamin dioxygenas kynureninetryptophan kyntrp pathway lead potenti neurotox imbal kyntrp pathway metabolit quinolin acid qa n methyl aspart glutamaterg receptor nmdar agonist kynuren acid ka nmdar antagonist determin whether qaka ratio associ cognit dysfunct cd depress sle
D060825;D008180
T048;T047
34,686,583
characterist outcom pediatr nonindex readmiss evid florida hospit increas pediatr care region may inadvert fragment care children readmit differ nonindex hospit rather discharg index hospit therefor studi aim assess trend pediatr nonindex readmiss rate examin risk factor determin destin differ affect readmiss outcom
D006761;D010359
T058;T093;T073
34,686,581
anatomi lumbar interspin ligament find relev epidur insert use loss resist loss resist techniqu use determin entri epidur space often midlin needl interspin ligament ligamentum flavum anatom explan loss resist without entri epidur space lack investig aim improv morphometr character lumbar interspin ligament observ measur dissect mri
D004824;D017843
T023;T030
34,686,579
posterior hip pericapsular neurolysi phpn inoper hip fractur adjunct anterior hip pericapsular neurolysi develop anterior hip neurolysi made appreci impact manag patient inoper hip fractur nonetheless suboptim analges benefit still observ patient therefor develop novel posterior hip pericapsular neurolysi phpn complement anterior hip neurolysi inoper hip fractur
D006620;D009407
T061;T037
34,686,575
exposur corticosteroid pregnanc associ advers perinat outcom among infant mother inflammatori bowel diseas result piano registri activ inflammatori bowel diseas ibd pregnanc may requir use corticosteroid aim studi investig impact utero corticosteroid exposur advers pregnanc outcom congenit malform infect neurocognit develop among offspr mother ibd
D002971;D002972;D015212;D011248;D047928
T047;T019;T046
34,686,574
carotid arteri revascular use walrus balloon guid cathet safeti feasibl us multicent experi walrus balloon guid cathet bgc new generat bgc design elimin convent limit mechan thrombectomi
D016893;D020521
T047;T020
34,686,573
predict bleb format intracrani aneurysm use machin learn model base aneurysm hemodynam geometri locat patient popul bleb presenc intracrani aneurysm ia known indic instabl vulner
D017542;D002532
T190;T047;T046
34,686,567
prognost valu coronari comput tomographi angiograph deriv fraction flow reserv systemat review meta analysi obtain power assess prognost valu fraction flow reserv ct test perform systemat literatur review collabor meta analysi studi assess clinic outcom ct deriv calcul ffr ffr ct heartflow analysi patient stabl coronari arteri diseas cad
D003324;D023921;D053805;D009203
T047;T201
34,686,566
contrast trend heart failur incid younger older new zealand studi indic age standardis heart failur hf incid decreas intern howev contrast trend differ age group report rate increas younger peopl decreas elder aim describ age specif trend hf incid new zealand nz
D006333;D017202
T047;T046
34,686,560
vitamin insuffici covid influenza critic ill survivor cross section studi steroid hormon vitamin role immunomodul bone health insuffici associ suscept respiratori infect report hydroxi vitamin oh measur hospitalis peopl covid influenza survivor critic ill test hypothes vitamin insuffici scale ill sever persist survivor
D000086382;D053118;D007251;D014808
T047;T005;T067
34,686,559
measur perceiv impact evid base leadership nurs mix method systemat review protocol despit abund exist literatur evid base nurs practic knowledg regard evid base leadership leadership support evid base approach lack aim conduct mix method systemat review qualit quantit studi examin evid use solv leadership problem describ measur perceiv effect evid base leadership nurs nurs leader perform well organis clinic outcom
D007857;D009718
T097;T054;T078
34,686,558
implement medicin cannabi australia innov upheav perspect physician key inform qualit analysi sought explor physician perspect prescrib cannabinoid patient gain deeper understand issu face prescrib public health advisor rollout medicin cannabi
D002188;D058006;D064086;D010820
T121;T002;T109;T073;T167;T097;T091;T093
34,686,557
kidney diseas risk dementia danish nationwid cohort studi unclear whether kidney diseas risk factor develop dementia examin associ kidney diseas risk futur dementia
D003704;D015140;D007674
T048;T047