PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,678,503 | novel semi quantit methodolog nation poliovirus reintroduct outbreak risk assess intern health regul world health organ member state need verifi certif polio free status annual australia sought reassess comprehens characteris risk pose wild type vaccin deriv poliovirus introduct nation health secur howev formal guidelin nation polio risk assess public avail | D011051;D017955 | T047;T005 |
34,678,502 | schistosoma haematobium infect pulmonari involv travel return congo case report systemat review literatur nodular pulmonari schistosomiasi schistosomiasi high preval sub saharan africa diagnosi difficult travel medicin practition affect differ organ atyp manifest haematobium most associ urinari involv rare pulmonari lesion review aim summaris pulmonari form associ schistosomiasi especi haematobium | D012553 | T047 |
34,678,501 | equin flexor tendon imag part current status futur direct advanc diagnost imag focus deep digit flexor tendon flexor tendon injuri common caus lame earli retir equin athlet ultrasonographi frequent utilis advanc diagnost imag modal becom wide avail detect monitor flexor tendon lesion part two literatur review detail current experi low high field magnet reson imag mri comput tomographi ct diagnosi equin flexor tendinopathi focus deep digit flexor tendon implic magic angl artefact well inject techniqu use contrast media discuss futur develop tendon imag aim gain enhanc structur inform tendon architectur prospect prevent injuri techniqu describ assess human achill tendon includ ultra high field mri positron emiss tomographi highlight | D006734;D052256;D013708 | T047;T037 |
34,678,500 | equin flexor tendon imag part recent develop ultrasonographi focus superfici digit flexor tendon flexor tendon injuri major caus lame perform hors consider impact equin welfar wider hors industri age repetit strain frequent caus vari degre tendon micro damag prior recognit clinic tendinopathi whilst b mode ultrasonographi common utilis detect monitor tendon lesion metacarpalmetatars level emphasi recent research focus identif subclin tendon damag order prevent tendon injuri improv outcom introduct elastographi acoustoelastographi ultrasound tissu characteris field equin orthopaed show promis result might find wider use equin practic clinic develop continu base substanti number research studi tendon imag publish past decad literatur review aim examin current use ultrasonograph imag techniqu limit introduc critic apprais new modal could potenti chang clinic approach equin flexor tendon imag | D006734;D052256;D013708 | T047;T037 |
34,678,497 | omalizumab induc aspirin toler nonsteroid anti inflammatori drug exacerb respiratori diseas patient independ atop sensit nonsteroid anti inflammatori drug nsaid exacerb respiratori diseas n erd compris triad chronic rhinosinus nasal polyp crswnp asthma intoler inhibitor cyclooxygenas enzym impact omalizumab prevent aspirin induc hypersensit n erd patient without atop sensit thorough address | D009298;D004364;D012220 | T047;T121 |
34,678,495 | evalu visual plan print techniqu alveolar cleft repair effect patient burden aim studi describ auxiliari surgic techniqu alveolar cleft reconstruct evalu patient burden year surgic experi | D064728;D002972 | T019;T061 |
34,678,494 | sirtuin function metabol role pancrea liver adipos tissu crosstalk impact bone homeostasi mammalian sirtuin sirt member nicotin adenin dinucleotid nad depend famili enzym critic histon deacetyl posttransl modif protein sirtuin famili member regul wide spectrum biolog process best known maintain longev sirtuin well character metabol tissu pancrea liver adipos tissu regul divers rang stimuli includ nutrient metabol chang within organ inde nutrient associ condit obes anorexia nervosa found associ bone fragil develop osteoporosi interest also demonstr sirtuin specif sirt regul bone activ various studi demonstr import sirtuin bone regul bone homeostasi mainten balanc bone resorpt bone format howev understand molecular mechan involv negat regul bone homeostasi overnutrit obes undernutrit crucial examin wider pictur determin pancreat liver adipos tissu pathway crosstalk respons bone loss particular condit sirtuin famili member high express metabol tissu phenomenon revers bone sever bone loss observ human subject associ bone loss may connect sirt defici howev addit factor may interfer bone homeostasi thus review focus sirtuin activ pancrea liver case undernutrit especi regul secretom sirtuin furthermor examin secretom pancrea liver affect bone homeostasi focus undernutrit review aim lead better understand crosstalk sirtuin metabol organ bone long term prospect contribut promot improv therapeut strategi prevent metabol diseas develop osteoporosi | D037761 | T116;T126 |
34,678,493 | combin result three physic perform test predict incid fractur independ abmd communiti dwell elder japanes men fujiwara kyo osteoporosi risk men formen cohort studi sever studi examin associ physic perform fractur women studi target elder men studi aim determin whether combin result sever physic perform test predict subsequ incid fractur elder men adjust confound factor | D010024;D058866 | T047 |
34,678,492 | phenotyp profil aed albopictus skuse expos pyrethroid base mat vapor under detoxif mechan statewid report selangor malaysia studi examin biolog efficaci four mosquito mat vapor contain differ activ ingredi prallethrin pbo dimefluthrin prallethrin allethrin glass chamber assay use evalu efficaci aed albopictus skuse diptera culicida nine district selangor malaysia aed albopictus exhibit differ knockdown rate knockdown time kt vari min min min min prallethrin pbo dimefluthrin prallethrin allethrin respect general popul ae albopictus complet knock exposur activ ingredi except hulu selangor popul show knockdown allethrin contrari mortal rate observ popul test prallethrin pbo dimefluthrin prallethrin allethrin respect moreov signific correl mortal rate prallethrin pbo vs dimefluthrin r p prallethrin pbo vs prallethrin r p prallethrin vs allethrin r p also observ suggest cross resist among pyrethroid allethrin found high insecticid activ follow prallethrin prallethrin pbo dimefluthrin consist mortal due insecticid exposur elev level enzym activ also demonstr sabak bernam hulu selangor gombak petal hulu langat klang popul | D000330;D007306;D009032;D009330 | T131;T204;T074;T057 |
34,678,491 | design phase iii efficaci immunogen safeti studi valent human papillomavirus vaccin prevent oral persist infect men seven high risk human papillomavirus hpv type cover valent hpv vhpv vaccin caus hpv relat head neck cancer hncs ongo clinic trial nct design evalu vhpv vaccin efficaci hpv oral persist infect surrog endpoint hpv relat hncs | D030361;D053918 | T129;T047;T121;T116 |
34,678,490 | paracelsus legaci faunal realm drug deriv anim toxin given vast number venom poison anim surpris relat anim deriv toxin explor made way market drug investig ongo clinic trial review highlight market drug deriv anim toxin well ongo clinic trial preclin investig field emphas attent paid rich suppli candid natur provid valuabl start point address serious unmet medic need | D014118;D014688 | T131;T116;T123 |
34,678,489 | receptor ligand herp simplex virus novel insight drug target human herp simplex virus hsvs belong herpesvirida famili present vaccin curat treatment avail prevent hsv infect review cell surfac receptor recogn hsv glycoprotein b glycoprotein c glycoprotein glycoprotein h glycoprotein l complex facilit entri host cell receptor includ heparan sulfat hs herpesvirus entri mediat hvem nectin sulfat heparan sulfat os hs | D006561;D018259;D008024;D014759 | T116;T047;T123;T005;T103 |
34,678,488 | mg mark poor beta cell perform predict onset type diabet subject differ degre glucos toler mg myokin modul insulin signal sever tissu relationship glucos toler risk develop type diabet mellitus tdm unknown observ prospect studi aim evalu relationship mg glucos toler test whether circul level may associ diseas progress cohort high risk tdm | D003924;D018149;D007333 | T047;T046 |
34,678,487 | configur intracort microelectrod array stimulus paramet minim neuron loss prolong intracort electr stimul previous studi shown neuron cerebr cortex injur implant stimul implant microelectrod | D002540;D009474 | T025;T023;T029 |
34,678,485 | ectop expans vascular engin hepat tissu base heparin acellular liver matrix mesenchym stromal cell spheroid engin liver organogenesi yet viabl therapeut option ectop liver histogenesi may possibl accumul evid suggest cell cell interact cell matrix interact play import role determin properti engin hepat tissu vitro vivo current studi util heparin decellular liver scaffold bone marrow mesenchym stromal cell spheroid fabric engin hepat tissu subsequ implant omentum spragu dawley rat without liver injuri surviv liver specif function differenti level regen potenti implant hepatocyt like cell ectop liver system evalu togeth vascular status therapeut potenti engin hepat tissu demonstr hepat graft could surviv possess hepatocyt specif function ectop liver system could also effici anastomos host vascular network furthermor found hepatocyt like cell within graft expand fold cours week immunocompet rat injur liver immunostain reveal hepatocyt like cell could self organ cord like structur vivo addit hepat graft exhibit therapeut potenti liver injuri induc ccl knowledg first report demonstr generat long term vascular hepat parenchyma ectop site base decellular liver scaffold stem cell result provid econom feasibl method engin hepat tissu construct transplant methodolog may applic clinic medicin especi metabol liver diseas statement signific manuscript present optim method hepat engin tissu het construct transplant core method util combin heparin decellular liver scaffold stem cell spheroid could provid necessari cell cell cell extracellular matrix interact het vitro vivo prove hepat graft could possess hepatocyt specif function exhibit strong prolif activ ectop liver system also abl anastomos host vascular network effici compat host immun system methodolog may possibl one day appli clinic medicin especi metabol liver diseas | D059630;D023822 | T025;T061 |
34,678,484 | bone marrow mesenchym stem cell offer immun privileg nich cutibacterium acn case implant associ osteomyel consid devast complic cutibacterium acn c acn relat osteomyel among hardest infect diagnos treat mesenchym stem cell mscs secret number immunomodulatori antimicrobi solubl factor make attract treatment bacteri infect studi examin mscsc acn interact analyz subsequ mscs bacteria behavior human bone marrow deriv mscs infect c acn clinic strain harvest non infect bone site follow h interact around bacteria found intracellular compart infect mscs increas secret prostaglandin e indolamin dioxygenas immunomodulatori mediat viabl intracellular bacteria analyz infrar spectroscopi atom forc microscopi reveal deep modif wall featur comparison unchalleng bacteria viabl intracellular bacteria show increas biofilm format orthopaed base materi ii increas invas osteoblast iii persist macrophag suggest acquisit virul factor overal result show direct impact c acn bone marrow deriv mscs suggest block c acnesmsc interact may repres import new approach manag chronic osteomyel infect statement signific interact bone commens c acn bone marrow mesenchym stem cell induc modif c acn wall characterist bacteria increas biofilm format orthopaed base materi ii invas bone form cell iii resist macrophag clearanc modif wall nano featur andor increas catalas product | D059630;D010019 | T025;T047 |
34,678,483 | automat track healthi joint kinemat stereo radiographi sequenc kinemat track healthi joint radiographi sequenc frequent perform maxim similar comput perspect project comput model correspond object appear radiograph imag signific human effort associ manual track present major bottleneck biomechan research method limit scale target applic current work introduc method fulli automat track tibiofemor patellofemor kinemat stereo radiographi sequenc subject perform dynam activ propos method involv applic convolut neural network annot radiograph multi stage optim pipelin estim bone pose base inform provid neural net predict predict kinemat evalu compar manual track trend across distinct trial median absolut differ millimet degre tibiofemor patellofemor degre freedom demonstr util approach improv upon previous semi automat method enabl end end autom implement fulli automat pipelin kinemat track benefit evalu human movement enabl larg scale studi healthi knee kinemat | D021621;D007719 | T062;T073;T060;T030 |
34,678,482 | assess popul sampl strategi reduc covid incid long critic level vaccin reach ensur heard immun new sar cov strain develop realist way reduc infect speed popul track infect individu pass virus test popul via sampl shown good result slow epidem spread sampl implement differ time epidem may done either per individu combin group peopl time work present make two main contribut first extend refin scalabl agent base covid simul incorpor improv socio demograph model consid profess well realist popul mix model base contact matric per countri extens necessari develop test various sampl strategi scenario includ largest citi spain second contribut part evalu also analyz impact differ paramet test frequenc quarantin time percentag quarantin breaker group test sampl efficaci result show effect strategi pool rapid antigen test campaign requir negat test access public area effect strategi great increas reduc number contact infect individu | D000086382 | T047;T067 |
34,678,481 | review omic base biomark discoveri alzheim diseas bioinformat perspect statist approach vs machin learn approach alzheim diseas ad neurodegen diseas affect cognit common caus dementia elder number elder individu increas global incid preval ad expect increas present ad diagnos clinic accord accept criteria essenti element diagnosi ad includ patient histori physic examin neuropsycholog test addit appropri investig neuroimag omic base approach emerg field studi may aid diagnosi ad also facilit explor factor influenc develop diseas omic techniqu includ genom transcriptom proteom metabolom may reveal pathway lead neuron death identifi biomolecular marker associ ad facilit understand ad neuropatholog review omic base approach implement studi ad assess bioinformat perspect current state art statist machin learn approach use singl omic analysi ad compar base correl variant differenti express function analysi network analysi follow review approach use integr analysi multi omic ad strength limit multi omic analysi method explor issu challeng associ omic studi ad highlight last futur studi area research justifi | D000544;D019636 | T048;T047 |
34,678,480 | predict fluid respons heart hemodynam manag model base solut intraven fluid infus import therapi patient circulatori shock howev challeng predict patient cardiac stroke volum sv respond thus identifi much fluid deliv model predict sv time profil respons fluid infus could potenti use guid fluid therapi | D005440;D006439 | T042;T061 |
34,678,479 | segment techniqu dynam ensembl select enhanc glaucoma sever detect sever glaucoma observ categoris glaucoma diseas sever class base classif process two suitabl paramet cup disc ratio cdr peripapillari atrophi ppa common use identifi glaucoma util studi strengthen classif first activ contour snake ac employ retriev optic disc od optic cup oc valu requir calcul cdr moreov otsu segment threshold techniqu use identifi ppa featur extract use grey level co occurr matrix glcm advanc segment techniqu combin improv classifi call dynam ensembl select des propos classifi glaucoma des general use handl imbalanc dataset propos model expect detect glaucoma sever determin subsequ treatment accur propos model obtain higher mean accuraci deep learn base u net evalu use three dataset retin fundus imag train test base fold cross valid scheme | D005901;D009898 | T033;T023;T047 |
34,678,476 | associ interleukin vitamin serum level patient obstruct sleep apnea syndrom impact long term continu posit airway pressur therapi biomark level hypoxia induc interleukin il product obstruct sleep apnea syndrom osa low serum hydroxyvitamin oh level link osa suscept serum oh level negat correl serum il level patient chronic inflamm data exist assess whether correl oh il serum level osa impact continu posit airway pressur cpap therapi il oh level need investig aim compar serum oh il level osa patient control examin possibl correl oh il level chang concentr twelv month cpap therapi osa patient | D045422 | T061 |
34,678,475 | influenc intrathorac vagotomi cough reflex anesthet cat recurr laryng affer fiber primarili respons cough respons mechan chemic stimul upper trachea larynx guinea pig lower airway slowli adapt receptor propos permiss effect cough reflex hypothes vagotomi recurr laryng nerv branch would depress mechan chemic induc cough anesthet bilater thoracotom artifici ventil cat thorac vagotomi near elimin cough induc mechan stimul intrathorac airway signific depress mechan stimul laryng cough elimin capsaicin induc cough result support import role lower airway sensori feedback product tracheobronchi laryng cough cat least feedback due excit pulmonari volum sensit sensori receptor | D014628 | T061 |
34,678,472 | role workplac bulli low back pain studi civil servant middl incom countri cross section studi analys associ workplac bulli lbp particip judici civil servant porto alegr southern brazil workplac bulli measur negat act questionnair naq r low back pain nordic questionnair musculoskelet symptom nqms logist regress use analys data test hypothes preval lbp last day overal preval chronic lbp psychosoci factor work strong associ outcom workplac bulli strong associ lbp even adjust sever covari odd lbp last day among bulli worker ci time higher compar non bulli workplac bulli also associ chronic lbp adjust sociodemograph behaviour occup factor ci psychosoci factor work particular workplac bulli strong risk factor lbp contrast individu factor dose respons pattern show posit associ bulli lbp rais hypothes causat role psychosoci factor work discuss longitudin studi address hypothes investig causal path mechan possibl mediat perspect psychosoci risk workplac bulli may play role low back pain focus intervent prevent lbp dose respons pattern associ workplac bulli low back pain discuss hypothes rais paper address differ way measur categoris bulli work order studi relationship bulli pain | D017116;D009784;D000073397 | T047;T184;T048;T054;T033 |
34,678,471 | make pain research inclus current knowledg mechan intervent pain larg deriv sampl healthier wealthier younger like white general popul failur conduct inclus pain research restrict generaliz applic find also hamper discoveri mechan develop measur intervent valid across popul subgroup inclus practic critic ensur underrepres group deriv equit benefit pain research provid guidanc pain research communiti adopt inclus research practic defin inclus encompass rang ident characterist includ racial groupethn disabl status gender ident sexual orient age first describ principl relev promot inclus pain research includ attent stakehold engag structur factor under inequ limit dispar research intersect univers design next provid checklist practic strategi make studi inclus stage research process conclud call system level chang ensur futur pain research social scientif product respons need peopl perspect paper offer guidanc promot inclus underrepres group pain research describ principl relev conduct inclus research eg attent stakehold engag structur factor univers design provid checklist practic strategi inclus stage research process | D005783;D012725 | T032;T053;T041;T055 |
34,678,470 | spinal aminobutyr acid interneuron plastic involv reduc analges effect morphin neuropath pain system administr morphin increas serotonin ht spinal dorsal horn sdh attenu analges effect morphin neuropath pain spinal ht receptor hypothes dysfunct descend serotonerg system includ periaqueduct gray pag contribut attenu efficaci morphin neuropath pain spinal ht receptor gaba neuron morphin ng inject pag produc analges effect normal rat spinal nerv ligat snl rat vivo microdialysi show pag morphin increas sdh ht concentr group intrathec inject ht receptor antagonist ondansetron gaba receptor antagonist bicucullin attenu analges effect pag morphin normal rat increas effect snl rat increas analges effect pag morphin induc bicucullin revers pretreat tropomyosin receptor kinas b trkb antagonist ka activ spinal ht receptor methyl ht increas gaba concentr group morphin activ gabaerg interneuron sdh activ descend serotonerg neuron function chang gaba receptor inhibitori facilitatori activ trkb receptor may contribut attenu efficaci morphin neuropath pain perspect although morphin provid strong analgesia acut pain limit efficaci neuropath pain articl demonstr function chang gaba receptor spinal dorsal horn nerv injuri might strong contribut attenu opioid induc analgesia neuropath pain | D009020;D009437 | T047;T121;T184;T109 |
34,678,469 | delay effort base discount role bodili awar peopl experienc long term pain cross section studi pain intervent typic includ effort exercis long term treatment ie short term cost effort delay benefit improv pain andor function thus understand long term pain influenc decis make context delay effort essenti given clear relev treatment uptak andor adher evalu delay effort attitud experienc chronic pain n pain free control n addit investig role bodili sensat awar andor interpret potenti contribut factor alter decis make volunt complet three discount questionnair assess influenc tempor delay gain loss effort devalu monetari outcom individu chronic pain short sight decis monetari gain loss decreas willing undertak effort monetari gain pain group pain group higher bodili sensat awar relat higher impuls delay effort discount neither awar interpret bodili sensat interact pain level explain group differ discount behavior find suggest impair delay effort base discount present peopl chronic pain may driven pain induc chang pain induc enhanc bodili sensat awar andor interpret explor util intervent target discount behavior warrant data avail studi materi avail https osfiozexm viewonlycccdafb perspect peopl chronic pain make short sight decis prefer less reward sooner decreas willing undertak effort prefer less reward littl effort monetari gain peopl without pain intervent target discount behavior may help improv uptak adher evid base effort treatment exercis | D059350;D065786 | T047;T184;T041;T055 |
34,678,468 | pain scienc educ plus exercis therapi chronic nonspecif spinal pain systemat review meta analys random clinic trial exercis therapi educ recommend sever guidelin manag symptom chronic nonspecif spinal pain cnsp patient howev systemat review previous analyz effect pain scienc educ pse plus exercis therapi manag cnsp relat symptom systemat search conduct databas look random control trial rcts aim evalu effect pain disabl kinesiophobia catastroph data analyz use random effect meta analys studi apprais use cochran rob tool grade total eight rcts n includ qualit analysi five select meta analysi pse plus exercis therapi show improv pain rcts short term smd rcts intermedi term smd low qualiti disabl rcts short term smd rcts intermedi term smd low low qualiti kinesiophobia rcts short term smd rcts intermedi term smd moder low qualiti catastroph rcts short term md point rcts intermedi term md point low low qualiti compar exercis alon qualit analysi show improv experiment group compar multimod physiotherapi rct low low qualiti wherea clear benefit report compar pse alon rct low qualiti intervent rct low qualiti low low certainti evid suggest pse plus exercis therapi reduc cnsp relat symptom perspect base low qualiti data small sampl pse plus exercis therapi reduc cnsp relat symptom evid requir investig due limit number studi short follow period crd | D059350;D006233 | T047;T184;T101 |
34,678,467 | substanc p serum degrad complex region pain syndrom anoth piec puzzl previous studi demonstr serum peptidas system might less effici complex region pain syndrom crps sinc neuropeptid substanc p sp contribut inflamm crps investig metabol sp crps specif sp metabol assay perform crps patient constitut subgroup previous investig bk degrad addit includ healthi control newli recruit plus previous investig patient limb trauma fulfil crps diagnost criteria trauma control tc includ adapt thin layer chromatographi assay tlc quantifi sp disappear incub l serum result compar bradykinin bk metabol bk bk fragment previous studi addit tc clinic quantit sensori test qst phenotyp phenotyp crps patient retriev exist databas sp metabol less effici crps tc patient serum vs human control hc serum p suggest reduc activ neutral endopeptidas nep andor angiotensin convert enzym ace togeth decreas occurr bk fragment crps tc suggest reduc activ angiotensin convert enzym ace clear clinic phenotyp relat impair sp degrad durat diseas gender also associ import result tc differ crps collect current previous experiment result suggest limb trauma reduc serum peptidas metabol sp ex vivo specif serum ace activ howev find crps specif seem rather long term consequ trauma perspect experiment data studi support hypothesi impair metabol inflammatori peptid potenti contribut develop posttraumat pain crps limb trauma patient | D020918;D007703 | T129;T047;T116;T126 |
34,678,466 | worri trial efficaci onlin dialect behaviour therapi skill train chronic pain idbt pain use singl case experiment design emot dysregul frequent co occur chronic pain turn lead heighten emot physic suffer cycl associ prompt recommend psycholog treatment chronic pain target mechan emot regul current trial address need investig new internet deliv treatment incorpor emot skill train dialect behavior therapi dbt use singl case experiment design suit heterogen popul demonstr efficaci small sampl three particip chronic pain recruit particip receiv four week onlin dbt skill train idbt pain intervent incorpor one one session zoom web app result reveal compel evid intervent primari outcom emot dysregul promis secondari outcom pain intens improv also identifi pre post measur depress cope behavior sleep problem wellb harm avoid indic intervent may posit influenc factor relat chronic pain overal trial provid preliminari efficaci intervent improv chronic pain howev recommend investig idbt pain intervent either singl case trial conduct scientif rigor may aggreg deriv nomothet conclus group comparison trial compar usual mode treatment perspect trial advanc understand emot focus treatment chronic pain provid evid viabl new technolog treatment import internet deliv approach idbt pain intervent access restrict mobil remot communiti often limit psycholog servic peopl chronic pain | D059350;D000077252 | T047;T184;T061 |
34,678,465 | chronic pain preval factor associ high impact chronic pain follow total joint arthroplasti observ studi hip knee shoulder arthroplasti among frequent perform orthopaed procedur unit state high impact bothersom chronic pain rate follow total joint arthroplasti tja unknown factor predict chronic pain outcom retrospect observ studi includ individu tja januari januari n pre oper clinic encount inform extract electron health record chronic pain state determin email survey predictor variabl includ tja locat number surgeri comorbid tobacco use bmi pre oper pain intens primari outcom high impact bothersom chronic pain rate high impact pain ci compar knee hip shoulder increas risk high impact pain includ non white race two comorbid age less year pre oper pain score higher knee arthroplasti post oper survey complet month less rate bothersom chronic pain ci also compar knee hip arthroplasti higher shoulder increas risk bothersom chronic pain includ non white race shoulder arthroplasti knee arthroplasti current past tobacco use femal perspect cohort rd individu report high impact bothersom chronic pain follow tja non white race knee arthroplasti two variabl associ chronic pain outcom | D019644;D019645;D059350 | T047;T184;T061 |
34,678,464 | machin learn base investig relationship gut microbiom obes status gut microbiota believ play crucial role obes howev consist find among publish studi regard microbiom obes interact relat rare one under caus could limit sampl size cohort studi order identifi gut microbiota chang normal weight individu obes individu fecal sampl along phenotyp inform chines individu collect analyz compar normal weight individu obes individu exhibit lower divers speci higher divers metabol pathway addit various machin learn model employ quantifi relationship obes status bodi mass index bmi valu support vector machin model achiev best perform classif accuraci r score addit two well establish obes associ speci three speci potenti obes relat biomark includ bacteroid cacca odoribact splanchnicus roseburia homini identifi analys function pathway also reveal enrich pathway obes individu collect data demonstr tight relationship obes gut microbiota larg scale chines popul find may provid potenti target prevent treatment obes | D000069196 | T007;T001 |
34,678,463 | hyperacut reject abo incompat kidney transplant signific isoagglutinin subclass abo incompat transplant expand limit donor pool kidney transplant despit success desensit protocol immunosuppress undesir case hyperacut reject occur | D016030 | T061 |
34,678,462 | impact differ dose antithymocyt globulin condit immun reconstitut upon hematopoiet stem cell transplant anti thymocyt globulin atg use prior allogen hematopoiet stem cell transplant allo hsct graft versus host diseas gvhd prophylaxi two differ atg dose mgkg evalu comparison group without atg therapi | D006086;D018380;D000074243 | T040;T047;T061 |
34,678,461 | microgli glutaminas defici mitig neuroinflamm associ depress glutaminas gls recent report express microglia play crucial role neuroinflam signific increas level gls mrna express togeth neuroinflamm pathway observ postmortem prefront cortex depress patient find function microgli gls depress neuroinflamm generat transgen mice gls cko postnat lose gls microglia detect chang lipopolysaccharid lps induc depress model lps induc anxietydepress like behavior attenu gls cko mice parallel signific reduct pro inflammatori cytokin abnorm microglia morpholog phenotyp prefront cortex reduc neuroinflamm gls defici microglia result less reactiv astrocyt gls defici enhanc mir p mir p level extracellular vesicl releas microglia thus suppress astrocyt activ via inhibit serpinan express togeth data reveal novel mechan gls neuroinflamm target gls microglia may novel strategi allevi neuroinflamm relat depress diseas | D005972;D017628 | T025;T116;T126 |
34,678,460 | explor link adolesc inhal misus suicid behaviour behaviour toxicolog perspect adolesc inhal misus known associ suicid thought behaviour associ persist even inhal misus ceas previous studi hypothesis associ may deriv socioeconom disadvantag vulner potenti mediat impuls associ may also due central nervous system depress effect inhal review take behaviour toxicolog perspect focuss particular serotonerg system hypothalam pituitari adren hpa axi potenti link adolesc inhal misus suicid behaviour challeng bridg pre clinic clinic literatur area discuss along promis avenu futur research ultim aim reduc suicid risk vulner adolesc popul group | D059020 | T033 |
34,678,459 | distribut virul determin streptococcus agalactia recov differ clinic sourc streptococcus agalactia group b streptococcus gbs pathobiont member human microbiota chang commens pathogen caus larg spectrum diseas studi assess virul determin gbs isol recov differ clinic sourc associ asymptomat symptomat clinic outcom present distinct capsular type antimicrobi resist profil abil uniqu strain colon caus infect differ subject also evalu pfge analysi observ given strain could associ asymptomat symptomat outcom cell wall anchor protein alpha c encod gene bac bca respect detect capsular type ib isol bca frequent among asymptomat outcom relat isol well high express hemolysincytolysin hc symptomat outcom relat isol produc strong biofilm frequent bacteri isol recov urin strong biofilm produc growth experi asymptomat outcom relat isol grew faster h end log phase taken togeth find show virul genotyp phenotyp featur gbs distinct sourc may help understand pathogen potenti predict differ clinic outcom | D013290;D013292 | T007;T047 |
34,678,458 | methionin defici promot mitophagi via lncrna pvt mediat promot demethyl bnip gastric cancer occurr recurr metastasi treatment major challeng treatment gastric cancer studi base methionin met depend characterist gastric cancer cell explor effect met defici occurr develop gastric cancer | D062085;D013274 | T191;T114;T123 |
34,678,457 | axon spheroid neurodegener axon spheroid bubbl like biolog featur form degener axon yet littl known influenc degen process format growth observ respons various degen trigger injuri oxid stress inflammatori factor neurotox molecul often contain cytoskelet element organell depend patholog insult coloc diseas relat protein amyloid precursor protein app ubiquitin motor protein initi format axon spheroid depend disrupt axon membran tension govern cytoskeleton structur calcium level short spheroid format engulf signal phosphatidylserin ps expos outer leaflet spheroid plasma membran suggest import role axon spheroid phagocytosi debri clearanc degener spheroid grow ruptur allow pro degen factor exit axon extracellular space acceler neurodegener though much remain discov area axon spheroid research promis lend insight etiolog neurodegen diseas may import target therapeut intervent review summar year work describ known axon spheroid structur regul function | D019636 | T047 |
34,678,456 | effect manganes peroxidas decomposit cellulos compon direct cellulolyt activ synergist effect cellulas herein unearth manganes peroxidas mnp phanerochaet chrysosporium lignin degrad enzym capabl direct decompos cellulos compon also boost cellulas activ mnp decompos various cellulos substrat carboxymethyl cellulos cellobios cmc avicel produc reduc sugar rather oxid sugar lacton ketoaldolas mnp mn ii acet buffer evolv mn iii acet complex function strong oxid non specif mn iii acet enabl cellulos decomposit catalyt mechan propos analyz catalyt product deriv mnp treat cellopentaos notabl mnp also boost cellulas activ cmc avicel even consid cellulolyt activ mnp best author knowledg first report demonstr previous unknown fungal mnp activ cellulos decomposit addit known delignif activ consequ result provid promis insight investig versatil lignin degrad biocatalyst | D002480;D020075 | T004;T116;T121;T126 |
34,678,455 | produc fucoxanthin alga recent advanc cultiv strategi downstream process fucoxanthin brown color pigment alga gain much attent industri research recent due numer potenti health benefit includ anti oxid anti cancer anti obes function although current commerci product main brown macroalga microalga rapid growth rate much higher fucoxanthin content demonstr higher potenti fucoxanthin produc factor concentr nitrogen iron silic well light intens wavelength play signific role fucoxanthin biosynthesi microalga two stage cultiv approach propos maxim product fucoxanthin valuabl metabolit sustain fucoxanthin product achiev use low cost substrat cultur medium open pond cultiv system util seawat nutrient recycl downstream process integr novel green solvent extract techniqu emerg promis extract techniqu | D058086;D012624 | T204 |
34,678,454 | biodegrad environment risk assess ecolog footprint wastewat technolog pharmaceut activ compound remov sever studi investig remov pharmaceut activ compound phac wastewat treatment technolog due risk compound pose environ sens advanc biolog process develop micropollut remov membran bioreactor move bed biofilm reactor thus review holist evalu biodegrad environment hazard phac biolog process assess includ remov effici environment risk ecolog footprint consumpt resourc energi atmospher emiss wast generat maximum concentr phac low neglig risk scenario treat wastewat potenti biolog process meet goal assess among evalu phac biodegrad paracetamol recalcitr diclofenac combin convent process advanc biolog process prove effici way remov sever phac main osmot membran bioreactor | D004364;D014874;D018508 | T131;T052;T121;T057 |
34,678,453 | biomass activ carbon deriv pine sawdust steam burst pretreat perfluorooctano acid methylen blue adsorpt use wast biomass prepar various product environment benign process good way practic green sustain develop paper high poros surfac area biomass activ carbon obtain pyrolysi pine sawdust without use chemic steam burst pretreat hydrotherm condit differ steam burst psi pressur structur surfac chemic group final activ carbon product compar character show specif surfac area micropor volum decreas increas pressur relat content oxygen contain function group chang slight sampl obtain follow psi pretreat hpb offer highest bet surfac area pore volum g cm g respect also achiev highest adsorpt amount methylen blue mb perfluorooctano acid pfoa | D002606;D008751 | T130;T121;T196;T109 |
34,678,452 | ferment lactic acid product seawe hydrolys use lactobacillus sp weissella sp lactic acid la essenti commod chemic bio base la rule market share macroalga desir feedstock la ferment due high carbohydr low lignin content ulva sp gracilaria sp sargassum cristaefolium evalu feedstock la ferment mild acid thermal hydrolysi sulfur acid concentr brown macroalga l rhamnosus l plantarum could efficaci util seawe sugar la product macroalga potenti replac lignocellulos biomass feedstock la ferment | D012624;D058836 | T204;T007 |
34,678,451 | investig hydrogen peroxid acet acid pretreat enhanc enzymat digest bamboo residu bamboo biomass wide consid promis substitut lignocellulos produc ferment sugar biofuel south china p amarus treat use hydrogen peroxid acet acid pretreat presenc sulphur acid h lignin remov bamboo residu enzymat saccharif yield ethanol content gl obtain analysi indic hpac pretreat increas hydrophil porous natur substrat improv enzym access cellulos hpac pretreat sinicus b lapidea n affini andd giganteus use substrat enzymat saccharif glucos yield h achiev hpac pretreat high effici environment friend method bamboo biorefineri south china | D019342;D006861 | T130;T121;T109;T197 |
34,678,450 | recent advanc futur direct valor spent mushroom substrat sms review commerci mushroom cultiv lignocellulos wast corncob saw dust straw wood chip follow rapid increas global mushroom product effici recycl util product known spent mushroom substrat sms garner much attent due serious pollut issu caus embrac concept circular economi smss demonstr immens potenti wide rang applic includ recycl substrat new cultiv cycl mushroom biofertil soil amend anim feed renew energi product pollut bioremedi review provid overview recent advanc focus applic analyz possibl challeng propos futur direct sustain develop global mushroom industri | D000363 | T004 |
34,678,449 | n n dimethylformamid solvent assist hydrotherm pretreat chlorella coproduct sugar nitrogen compound carbon dot microalga consid promis altern fossil fuel due eas cultiv short growth cycl occup cultiv land studi n n dimethylformamid dmf solvent employ assist hydrotherm pretreat chlorella coproduct sugar nitrogen compound carbon dot cds effect pretreat condit composit pyrolysi bio oil distribut hydrotherm solid residu well cds characterist investig vari temperatur reaction time h result show pretreat residu higher cellulos yield sugar n contain compound reach pyrolysi bio oil pretreat alga residu respect moreov cds obtain hydrotherm solut fluoresc red nm excit paper provid new method complet util microalga | D002708;D058086 | T204;T002 |
34,678,448 | nitrat remov alkali resist pseudomona sp xs aerob condit perform mechan improv poor nitrat remov microorgan strong alkalin condit new type aerob nitrif reduc bacteria isol studi use nitrogen balanc genom inform capac pseudomona xs remov nitrat mechan alkali toler analyz ph xs could remov mg n lh nitrat cn ratio c nitrit ammonia nitrogen bare enrich xs could reduc nitrat dissimil assimil nitrat convert cellular compon organ nitrogen respect meanwhil function gene nirbd nasab gdha glna gltbd associ nitrogen metabol determin addit na h antiport mnhacdefg phaacdefg nhacd trkah cell surfac protein slpa xs genom well compat solut help stabil intracellular ph also character xs possess signific potenti alkalin wastewat treatment | D058440;D009566 | T197;T067 |
34,678,447 | effect mix primari secondari sludg two stage anaerob digest ad energi effici eco friend sludg treatment process two stage anaerob digest ad wide employ recoveri biomass energi wast sludg howev effect primari secondari sludg two stage ad clear studi two stage ad mix sludg differ volum ratio investig maximum cumul h yield ml ch yield ml obtain volum ratio primari sludg secondari sludg two phase ad mix sludg could induc posit effect organ releas extracellular polymer substanc ep util volatil fatti acid vfas investig composit characterist dissolv organ matter dom excit emiss matrix eem coupl fluoresc region integr fri reveal degrad substanc util mixtur sludg result work suggest two phase ad mix sludg effici renew energi recoveri | D000077317;D012722 | T069;T123 |
34,678,446 | viabl strategi enhanc aceton butanol ethanol product non detoxifi switchgrass hydrolys process engin strategi investig toward develop viabl scheme effect convers hydrothermolysi pretreat non detoxifi switchgrass hydrolys sh aceton butanol ethanol abe use metabol engin strain clostridium beijerinckii ncimb c beijerinckiiakr engin strain modifi homolog integr chromosom constitut express cbei encod aldo keto reductas intermitt feed strategi employ ferment initi sh remain sh ad optic densiti od nm c beijerinckii attain abe gl produc non detoxifi sh inhibitor toler c beijerinckiiakr compar p glucos control medium gl use intermitt feed wildtyp c beijerinckiiakr produc similar amount abe gl show intermitt feed strategi c beijerinckiiakr enhanc abe ferment elimin need sh detoxif prior ferment | D046970;D008897 | T007;T002 |
34,678,445 | incid predictor prosthet joint infect follow primari total knee arthroplasti year popul base cohort studi one devast complic total knee arthroplasti tka periprosthet joint infect pji although mani complic associ tka decreas time trend associ pji less clear thus purpos studi determin incid risk factor pji primari tka | D019645;D003924;D016459 | T047;T061;T046 |
34,678,444 | microrna pcpeb pathway mediat relat learn memori deficit mous model alzheim diseas alzheim diseas ad common neurodegen diseas main caus dementia cognit declin core symptom observ diagnosi synapt loss may main caus earli cognit dysfunct ad detail mechan still unclear studi investig role abnorm mir pcpeb pathway ad mous model found mir p upregul downstream target cytoplasm polyadenyl element bind cpeb downregul hippocampus appp mice age abnorm mir pcpeb pathway mediat cognit deficit appp mice suppress amino hydroxi methyl isoxazol propion acid ampa receptor express mir p suppress cpeb overexpress applic peptid disrupt mir pcpeb interact ca appp mice rescu ad like phenotyp mice includ deficit synapt plastic memori conclus result indic mirna pcpeb pathway mediat synapt memori deficit alzheim diseas target ampar provid potenti therapeut strategi ad | D000544;D035683;D019636;D014157;D039221 | T116;T047;T123;T048;T114 |
34,678,443 | inspir prevent treatment neuropsychiatr disord new insight bone brain axi bone main support structur bodi main organ involv bodi movement calcium phosphorus metabol recent studi shown bone also potenti new endocrin organ particip physiolog pathophysiolog process cardiovascular digest endocrin system various bioactiv cytokin secret bone cell bone marrow bone deriv activ cytokin also direct act central nervous system regul brain function individu behavior bidirect regul bone brain axi gradual attract attent field neurosci paper review regulatori effect bone deriv activ cytokin bone deriv cell individu brain function brain diseas well occurr develop relat neuropsychiatr diseas central regulatori mechan function briefli introduc broaden scope mechanist research help establish prevent treatment strategi neuropsychiatr diseas base bone brain axi | D001921;D002490 | T022;T023 |
34,678,442 | genom assist probiot character applic bacillus velezensi zbg altern antibiot growth promot broiler chicken present studi describ genom annot phenotyp character bacillus velezensi zbg evalu perform antibiot growth promot substitut broiler chicken zbg compris mbp genom gc content zbg could toler simul gastrointestin juic preval anim gut adhes associ genom featur zbg support experiment determin cell surfac hydrophob cell aggreg result zbg encod multipl secondari metabolit gene cluster correl broad spectrum antibacteri activ interest zbg complet inhibit salmonella enterica escherichia coli within h h liquid co cultur assay respect zbg genom analysi reveal genet determin associ report safeti hazard use poultri direct fed microbi dietari supplement zbg signific improv feed util effici humor immun respons broiler chicken suggest prospect applic direct fed microbi broiler chicken | D002645;D019936 | T007;T012 |
34,678,441 | heterolog product cellulos starch degrad hydrolas expand saccharomyc cerevisia substrat util lesson learnt select strain saccharomyc cerevisia use commerci bioethanol product cellulos starch high cost exogen enzym substrat hydrolysi remain challeng address consolid bioprocess cbp cerevisia strain engin express recombin glycosid hydrolas ferment look back numer strategi undertaken past four decad improv recombin protein product cerevisia evid various step protein product pipelin manipul depend protein interest anticip applic review briefli introduc strategi highlight lesson learn regard improv transcript translat post translat modif protein secret heterolog hydrolas examin host strain select modif well enzym compat crucial determin overal success final discuss lesson heterolog hydrolas express inform modern synthet biolog genom edit tool provid process readi yeast strain futur howev clear success express particular enzym still unpredict requir trial error approach | D012441;D013213 | T121;T109;T123;T004;T168 |
34,678,439 | gastroenteropancreat neuroendocrin neoplasm g novel insight unmet need accord patholog grade system high grade gastroenteropancreat neuroendocrin neoplasm gep nen divid well differenti neuroendocrin tumor g net g poor differenti neuroendocrin carcinoma nec gep net g gep nec present signific differ driver gene diseas origin net g nec confirm two distinct diseas differ genet background howev issu remain controversi prognosi net g signific better nec differenti diagnosi gep net g gep nec combin patient medic histori tumor histopatholog ki index daxxatrx tp rb express well immunohistochem indic addit treatment strategi two subgroup differ summar recent find focus genom clinic manifest diagnosi treatment aspect high grade gep nen g review may help understand carcinogenesi diagnosi treatment gep nen g | D007414;D018358;D010190;D013274 | T191 |
34,678,438 | ferruginol prevent degener dopaminerg neuron enhanc clearanc synuclein neuron cell lewi bodi characterist spheric inclus parkinson diseas pd form synuclein fibril ferruginol fer amonomer compound isol tradit chines herb show fer exert potent neuroprotect effect vitro vivo pd model neuron cell transfect mutant synuclein plasmid treat fer exhibit attenu cytotox induc pathogen synuclein overexpress transfect neuron cell sirna snca alpha synuclein plasmid incub fer protect role fer decreas also found fer potent synuclein inhibitor neuron cell promot clearanc synuclein dopaminerg neuron expos methyl phenylpyridinium mpp fer could inhibit abnorm synuclein aggreg dopaminerg neuron deplet tg mice suggest role fer synuclein accumul nigrostriat pathway injuri studi reveal fer strong allevi neurodegener promot synuclein clearanc indic neuroprotect role synuclein oligom induc neurodegener make promis candid treatment pd neurodegen diseas | D018696 | T169;T121 |
34,678,437 | dynam ethylammonium nitrat near ptfe surfac self diffus ion protic ionic liquid ethylammonium nitrat ean studi h nmr puls field gradient techniqu k presenc ptfe insert mm nmr tube temperatur bulk diffus ion measur h n nmr describ uniqu diffus coeffici presenc solid hydrophob surfac ptfe induc region ean vicin diffus ion cation anion reduc compar bulk valu addit line shape analysi h nmr spectra show local mobil ethylammonium cation surfac layer near ptfe also reduc | D052578;D000644 | T120;T103;T109 |
34,678,436 | cerebr aggreg g ratio map use magnet reson relaxometri diffus tensor imag investig sex age relat differ white matter microstructur axon demyelin cardin featur age age relat diseas g ratio mathemat defin inner outer diamet myelin axon use structur index optim axon myelin shown repres sensit imag biomark microstructur integr sever magnet reson imag mri method whole brain map aggreg g ratio introduc comput agger g ratio requir estim myelin volum fraction mvf axon volum fraction avf accur determin mvf avf obtain multicompon relaxometri diffus analys respect method requir lengthi acquisit time make implement challeng clinic context therefor attempt overcom drawback need expand previous work introduc new mri method whole brain map aggreg g ratio new approach base use singl shell diffus avf determin reduc acquisit time approxim min recent introduc approach offer possibl investig g ratio differ previous studi exist data mvf map singl shell diffus data avf map comparison analysi indic newli deriv aggreg g ratio valu similar deriv previous method requir longer acquisit time agreement previous observ found quadrat u shape relationship aggreg g ratio age much larger studi cohort howev result show sexual dimorph g ratio signific brain region investig | D056324;D066127 | T023;T024;T060 |
34,678,435 | evalu liver use molli gradient echo readout influenc fat effect hepat steatosi gradient echo gre base modifi look locker invers recoveri molli techniqu map evalu purpos studi evalu gre base molli techniqu hepat map determin relationship differ phase ip phase op fat fraction ff measur | D008099;D008279 | T170;T023;T059;T060 |
34,678,433 | role neural load effect predict individu differ work memori function studi work memori wm function tend adopt either within subject approach focus effect load manipul subject approach focus individu differ dichotomi extend wm neuroimag studi differ neural correl identifi within subject variat wm examin issu systemat fashion leverag larg sampl human connectom project dataset conduct well power whole brain analysi n back wm task first demonstr advantag parcel scheme dimens reduct term load relat effect size parcel base approach util direct compar relationship load relat within subject behavior individu differ subject effect correl predict analys result suggest strong linkag within subject subject variat larger load effect link stronger brain behavior correl frontopariet cortex hemispher bias found toward one type variat dorsal attent network exhibit greater sensit within subject variat wherea somatomotor network revers pattern observ cross valid predict model capit tight relationship two effect indic greater predict power load activ load deactiv parcel also demonstr load relat effect size serv effect guid featur ie parcel select maxim predict power maintain interpret togeth find demonstr import consist across within subject approach identifi neural substrat wm effect har develop power predict model | D007206 | T054 |
34,678,432 | x ray phase contrast virtual histolog evalu lung alter microbeam irradi studi provid first experiment applic multiscal dimension x ray phase contrast imag comput tomographi xpci ct virtual histolog inspect quantit assess late stage effect radio induc lesion lung small anim model | D014964 | T061 |
34,678,431 | sever persist late gastrointestin morbid local advanc cervic cancer lesson learn embrac implic futur purpos evalu patient treatment relat risk factor physician assess patient report gastrointestin gi symptom radio chemo therapi imag guid adapt brachytherapi local advanc cervic cancer | D001918;D002583 | T191;T061 |
34,678,430 | brain deriv neurotroph factor high throughput evalu select sigma receptor ligand sigma receptor sr endoplasm reticulum er chaperon protein implic attenu inflammatori stress mediat brain injuri select sr agonist repres new class therapeut agent treat neuropsychiatr neurodegen disord howev date sr ligand approv therapeut purpos use three potenti method known potenti sr ligand develop unambigu high throughput cell screen sr activ screen known potenti sr ligand use radioligand bind previous report marker sr activ includ bdnf releas modul ip mediat calcium releas modul ngf induc neurit sprout present result sever prototyp sr compound compound potenti drug repurpos use situ elisa approach demonstr compound could stimul sr mediat bdnf releas valuabl therapeut properti sinc bdnf play critic role neuron support compound classifi sr agonist bdnf respons compar prototyp agonist ppbp could revers sr select concentr antagonist bd modul ip mediat calcium respons ngf induc neurit sprout use measur sr activ unabl reproduc publish result determin reliabl measur evalu function properti sr ligand | D019208;D017480 | T192;T116;T123 |
34,678,429 | chronic bladder catheter precis urin collect awak mice metabol chamber routin use urin collect rodent mice due small urin volum evapor metabol chamber distort diuresi urinalysi paramet develop new techniqu bladder catheter enabl long term accur contamin free urin collect awak male femal mice day longer daili diuresi catheter mice twice higher compar metabol cage twofold differ urin recoveri preserv circadian variat diuresi effect furosemid desmopressin water load estim use two techniqu urin osmolar urinalysi microbiolog paramet evid higher qualiti cathet collect urin use phenol red demonstr util techniqu pharmacokinet studi day surgeri cathet patent minim impact anim heath bladder catheter use tool physiolog pharmacolog toxicolog studi | D001743;D059349 | T023;T059 |
34,678,426 | editori risk mental state arm diagnosi children adolesc predict transit psychot disord yet psychosi one extrem fear form psychopatholog earli intervent lead better outcom psychot disord field high motiv identifi problem earliest stage ideal earli intervent childhood adolesc would optim help restor healthi brain develop prevent onset psychot disord structur clinic interview develop identifi youth high risk psychosi base larg presenc attenu andor transient psychot symptom howev evalu challeng vast development differ among children adolesc adult experi understood express wake grow bodi literatur examin util assess risk mental state arm predict later transit psychot disord time ripe systemat review assess state emerg field | D011618 | T048 |
34,678,425 | system oxid stress old rat associ osteoporosi cognit impair age associ increas memori loss comorbid osteoporosi could causat link present studi deleteri effect bone demonstr first time model age rat impair memori show bone marrow progenitor cell obtain rat memori deficit decreas osteogen capac increas osteoclastogen profil adipogen capac compar age rat preserv memori rat impair versus preserv memori also show alter long bone micro architectur decreas trabecular bone osteocyt densiti increas trap posit osteoclast lower bone qualiti decreas trabecular bone miner content densiti increas bone marrow adipos interest develop bone alter memori deficit old rat associ signific higher level serum oxid stress versus unaffect age rat conclus found first time age rat model relationship alter bone qualiti memori impair increas system oxid stress possibl unifi mechan | D060825;D010024 | T048;T047 |
34,678,420 | nitroxideantioxid carbamoyl proxyl attenu diseas sever murin model sever asthma asthma character airway inflamm hyper respons symptom dyspnea wheez cough patient asthma well control use inhal corticosteroid bronchodil minor patient asthma develop sever diseas frequent partial respons even resist treatment corticosteroid sever refractori asthma associ structur chang airway term airway remodel andor neutrophil rather eosinophil airway inflamm oxid stress play import role pathophysiolog asthma cyclic nitroxid stabl radic uniqu effici catalyt antioxid effect protect oxid injuri demonstr nitroxid carbamoyl proxyl cp attenu airway inflamm hyperrespons allerg asthma well bleomycin induc fibrosi use murin model probabl modul oxid stress present studi evalu effect cp airway inflamm remodel use two murin model sever asthma mice sensit challeng either ovalbumin ova hous dust mite hdm cp oral administ entir period experi challeng period alon effect compar dexamethason induc increas ova hdm balf cell count airway hyperrespons fibrosi transform growth factor beta tgf level balf protein nitrat level lung tissu signific reduc cp effect cp use two differ murin model sever asthma associ least partial attenu oxid stress tgf express lung result studi suggest potenti use cp novel therapeut agent differ form sever asthma | D000975;D001249 | T044;T047;T121;T123;T039 |
34,678,419 | graphen quantum dot antioxid proautophag action protect sh syy neuroblastoma cell oxid stress mediat apoptot death investig abil graphen quantum dot gqd nanoparticl protect sh syy human neuroblastoma cell oxidativenitros stress induc iron nitrosyl complex sodium nitroprussid snp gqd reduc snp cytotox prevent mitochondri depolar caspas activ subsequ apoptot death although gqd diminish level nitric oxid snp expos cell scaveng display slight protect effect suggest quench main protect mechan gqd gqd also reduc snp trigger increas intracellular level hydroxyl radic oh superoxid anion lipid peroxid nonselect antioxid oh scaveng iron chelat superoxid dismutas mimick gqd cytoprotect activ indic gqd protect cell neutral oh generat presenc snp releas iron cellular intern gqd requir optim protect sinc remov extracellular gqd extens wash part diminish protect effect moreov gqd cooper snp induc autophagi confirm inhibit autophagi limit aktprasmtor signal increas autophagi gene transcript protein level proautophag beclin lc ii format autophag vesicl degrad autophag target p antioxid activ gqd involv autophagi induct antioxid n acetylcystein dimethyl sulfoxid fail stimul autophagi snp expos cell pharmacolog inhibitor earli wortmannin methyladenin late stage autophagi nh cl effici reduc protect effect gqd therefor abil gqd prevent vitro neurotox snp depend ohno scaveng induct cytoprotect autophagi | D006108;D009447;D045663 | T191;T073;T196;T109 |
34,678,418 | two cys type tetr repressor gbaa confer resist disulfid electrophil stress staphylococcus aureus staphylococcus aureus cope oxid electrophil stress host pathogen interact tetr famili repressor gbaa shown sens electrophil n ethylmaleimid nem via monothiol mechan two conserv cys cys residu vitro studi investig regul function gbaa repressor cys residu aureus col gbaa control gbaab sacol sacol nmra operon shown respond weak fold oxid electrophil antibiot aureus col fold derepress gbaa delet mutant indic physiolog induc still unknown moreov gbaa mutant remain respons disulfid electrophil stress point addit redox control mechan operon thiol stress induct gbaa regulon strong diminish singl cys mutant support cys residu requir redox sens vivo gbaa singl cys mutant revers oxid diamid allicin stress thiol switch affect dna bind activ repressor activ gbaa could partial inhibit nem vitro surviv assay reveal gbaa mutant confer resist diamid allicin nem methylglyox stress mediat sacol operon encod putat glyoxalas oxidoreductas altogeth result support gbaa repressor function defens oxid electrophil stress aureus gbaa repres cys type redox sensor requir anoth redox sens regul unknown thiol reactiv ligand full derepress gbaa regulon gene | D013203;D013211 | T007;T047 |
34,678,417 | advanc applic mass spectrometri imag technolog qualiti control safeti assess tradit chines medicin tradit chines medicin tcms made great contribut prevent treatment human diseas china especi case covid howev due qualiti problem lack standard divers dosag form advers reaction tcms often occur moreov composit tcms make extrem challeng extract isol complic studi toxic mechan | D000086402 | T005 |
34,678,416 | comprehens review ethnopharmacolog phytochemistri pharmacolog pharmacokinet schisandra chinensi turcz baill schisandra sphenanthera rehd et wil schisandra chinensi call bei wuweizi chines chinensi schisandra sphenanthera call nan wuweizi chines sphenanthera two high similar plant magnoliacea famili dri ripe fruit common use tradit chines medicin treatment cough palpit spermatorrhea insomnia also tradit use tonic russia japan korea | D020834 | T091 |
34,678,410 | date molecular phylogeni biogeograph analysi reveal evolutionari histori tran pacif disjunct tropic tree genus ormosia fabacea papilionoid legum genus ormosia fabacea compris speci tree exhibit strike disjunct geograph distribut new world asian australasian wet tropic subtrop modern classif ormosia ground well substanti phylogenet hypothesi limit portion geograph rang genus lack evolutionarili base foundat systemat studi hinder taxonom work genus prevent test biogeograph hypothes relat origin old worldnew world disjunct individu dispers histori within area present comprehens sampl molecular phylogeni ormosia date base analysi nuclear plastid matk trnl f dna sequenc speci genus phylogenet base diverg time ancestr rang estim employ test hypothes relat biogeograph histori genus find strong support monophyli ormosia group sampl asian speci genus two compar size clade one sister anoth larg clade contain sampl new world speci within new world clade addit resolut support group speci three mutual exclus subordin clade remain new world speci form fourth well support clade analys plastid sequenc result contradict analysi except support clade previous recogn taxonom group biogeograph analysi suggest ormosia origin continent asia dispers new world oligocen earli miocen via long distanc tran ocean dispers reject hypothesi inter hemispher disjunct ormosia result fragment continu boreotrop distribut sinc dispers post date eocen climat maxima old world clade appear origin mainland asia subsequ dispers malay archipelago beyond least two lineag dispers across wallac line far solomon island northeastern australia new world major clade origin amazonia dispers amazonia peripher area central america caribbean extra amazonian brazil occur multipl time vari time scale earliest begin late miocen case dispers follow local diversif revers migrat back amazonia within two main area distribut multipl modest bout ocean dispers requir achiev modern distribut | D007887 | T002 |
34,678,409 | hip gluteus medius tear associ lower femor neck shaft angl higher acetabular center edg angl assess possibl relationship morpholog femur acetabulum gluteus medius patholog analyz outcom isol arthroscop treatment femoroacetabular imping fai patient radiograph gluteus medius tear | D000077;D057925 | T023;T046 |
34,678,408 | natur protein base platform deliveri temozolomid acid glioma cell glioblastoma one difficult treat cancer poor prognosi surviv around one year diagnosi effect treatment desper need work aim prepar temozolomid acid tmza load albumin nanoparticl first time target glioblastoma gl brain cancer stem cell bl tmza load human serum albumin nanoparticl hsa nps use desolv method respons surfac level factori design use studi effect differ formul paramet drug load particl size nps optimum condit found mg tmza sodium cholat yield nps particl size drug load nm respect select formula found good shelf life serum stabil relat fast drug releas pattern optim nps show excel cellular uptak cell posit np uptak h incub gl bl glioblastoma cell line respect select formula show high cytotox cell viabil mm tmza h incub time final fluoresc label nps show co local bioluminesc syngen bl intra cranial tumour mous model intraven administr | D005910;D000077204 | T191;T121;T109 |
34,678,404 | trend incid dali anxieti disord global region nation level estim global burden diseas studi anxieti disord second lead mental health relat caus disabl adjust life year dali year live disabl ylds worldwid studi aim quantit assess burden anxieti disord global region nation level trend period | D000087509;D000071219 | T079;T081 |
34,678,403 | mental health impact perinat loss systemat review meta analysi perinat loss pose signific risk matern mental health limit data strength associ perinat loss subsequ common mental health disord cmhd anxieti depress post traumat symptom pts systemat review meta analysi identifi studi control group publish januari march report valid mental health outcom follow perinat loss identifi studi countri repres perinat loss sampl n control group women experienc loss n compar likelihood increas cmhd group random effect model suggest compar control perinat loss associ increas risk depress rr ci p k anxieti disord rr ci p k compar control perinat loss also associ increas depress smd ci p k anxieti score smd ci p k signific effect post traumat stress pts outcom k find confirm anxieti depress level follow perinat loss signific elev compar loss control live birth non pregnant communiti difficult live birth elev depress anxieti rate also report experienc loss later stage pregnanc assess mental health follow loss matern health prioriti | D001007;D008603 | T048;T184;T041 |
34,678,402 | dynam region activ putamen distinguish bipolar type depress unipolar depress intrins human brain activ time vari dynam howev still lack knowledg dynam region activ differ unipolar depress ud bipolar type depress bd whether differenti pattern help distinguish two patient group prone misdiagnosi clinic practic | D001714;D003866 | T048 |
34,678,401 | continu purif influenza virus particl use pseudo affin membran chromatographi robust flexibl continu unit oper enabl establish intensifi bioprocess one relev trend manufactur biopharmaceut includ virus base product sulfat cellulos membran adsorb scma one promis matric chromatograph purif virus particl like influenza virus three column period counter current set use continu purifi influenza apr virus particl use scma bind elut mode possibl recov ha activ remov total protein dna respect perform continu process oper total loop slight inferior obtain compar batch process nevertheless possibl increas effect usag bind capac result product khau ml memb min proof principl scma success use matrix purif cell deriv influenza virus particl continu mode | D009980;D009975 | T005 |
34,678,398 | mmp respons dual target drug deliveri system valenc control arsenic trioxid prodrug deliveri hepat carcinoma arsenic trioxid ato activ ingredi tradit chines medicin ie arsenic shown excel therapeut effect hepatocellular carcinoma howev due poor tumor distribut high toxic mass adopt ato clinic applic sever imped studi matrix metalloproteinas mmp respons cleav cell penetr peptid pf folat fa co modifi liposom coat calcium arsenat nanoparticl fapf lp caa fabric base two consider tumor microenviron character overexpress mmp extracellular matrix folat receptor cell membran enhanc drug accumul acceler endocytosi leverag differ toxic arsenic differ valenc state ie asv reduc toxic asiii glutathion tumor cell furthermor fapf lp caa could respons degrad mild acid tumor environ degrad product could escap lysosom endocytosi import light vivo biodistribut pharmacodynam studi vehicl abl accumul tumor effici also abl exhibit excel anti tumor efficaci minim side effect compar singl modifi counterpart thus novel strategi base tumor microenviron propos work enhanc tumor target effici intratumor toxic | D000970;D006528;D008113;D011355 | T191;T121;T109;T120 |
34,678,397 | stabil pharmacokinet biodistribut mice epac inhibitor r cef entrap liposom lipid nanocapsul r cef specif inhibitor epac exchang protein direct activ camp type demonstr vitro vivo reduc hypertroph signal contribut heart failur control arrhythmia shown promis drug candid howev r cef exhibit poor solubl aqueous media shown sensit enzym hydrolysi plasma overcom issu drug entrap liposom lipid nanocapsul system consider increas drug appar solubl aqueous media among nanocarri lipid nanocapsul offer signific protect vitro enzymat degrad increas r cef appar half life around min h pharmacokinet biodistribut r cef radiolabel studi healthi cbl mice non encapsul h cef show rapid distribut outsid blood compart similar result observ use nanocarri togeth fast dissoci h cef nanocapsul simultan label c thus essenti preclin inform cef fate obtain well impact formul use lipid base nanocarri | D053769 | T073 |
34,678,396 | span tpgs modifi lipid coat chitosan nanocomplex acyclovir topic deliveri system viral skin infect acyclovir acr consid gold standard drug treatment skin viral infect caus herp simplex varicella zoster virus howev topic therapi acr hinder poor skin penetr thus necessit high dose frequent administr studi propos formul modifi lipid coat chitosan nanocomplex lcncs acyclovir acr contain span tpgs boost dermal deliveri acr improv therapeut outcom lcncs formul self assembl method statist analysi optim perform via general factori design three formul variabl select name amount chitosan amount glyceryl monool gmo b span tocopheryl polyethylen glycol succin vitamin etpgsortpg ratio c four measur attribut determin viz particl size ps nm polydispers index pdi zeta potenti zp mv entrap effici percentag ee optim formul lcncs formul mg chitosan mg gmo span tpgs ratio possess ps nm pdi valu zp mv ee abl sustain acr releas h transmiss electron microscopi display lcncs architectur polymer core chitosan lipid coat gmo solid state character result confirm dispers acr lcncs ex vivo permeat studi vivo dermatokinet profil verifi boost accumul acr skin via lcncs confoc laser scan microscopi reveal heighten penetr lcncs topic applic lcncs demonstr safe profil via modifi draiz test histopatholog examin inclus acr load lcncs could promis topic formul advanc dermal deliveri status treatment skin viral infect | D048271;D053758 | T121;T073;T109 |
34,678,395 | microplast freshwat global review factor affect spatial tempor variat microplast pollut grow concern capabl harm aquat organ enter food web freshwat microplast research expand recent year much remain unknown regard sourc deliveri pathway microplast environ review aim address scientif literatur regard spatial tempor factor affect global freshwat microplast distribut abund total paper publish june contain earliest public date octob identifi web scienc databas search microplast spatial distribut heavili influenc anthropogen factor higher concentr report region character urban land cover high popul densiti wastewat treatment plant effluent spatial distribut may also affect physic watersh characterist slope elev posit negat correl microplast concentr respect although studi address factor tempor variabl influenc includ precipit stormwat runoff posit correl water flowdischarg negat correl despit overarch trend variat studi result may due differ scale contribut area delin thus rigor standard spatial analyt method need futur research could simultan evalu spatial tempor factor incorpor finer tempor resolut sampl campaign | D000080545;D014874 | T131;T122 |
34,678,394 | tissu distribut phthalat celeri differ cultiv pattern associ dietari exposur investig tissu distribut spatial differ temperatur variat potenti health risk pae veget celeri use model plant celeri sampl collect open field greenhous two provinc china four season celeri tissu analyz pae compound gas chromatographi tandem mass spectrometri total content pae g kg dri weight dw stem g kg dw leav concentr pae celeri show notabl spatial differ p level sampl open field lower sampl plastic greenhous celeri greenhous higher pae concentr observ plant grown high temperatur plant grown low temperatur discrep tissu distribut indic differ uptak pathway pae contamin risk assess human found carcinogen risk non carcinogen risk pae via celeri consumpt accept level research consid exposur pathway pae pay special attent reduc pae content veget | D000077102;D010795;D012989 | T131;T002;T109 |
34,678,392 | long term exposur ambient temperatur mortal risk china nationwid studi use differ differ design short term effect ambient temperatur mortal wide investig howev epidemiolog evid long term effect temperatur mortal rare present studi conduct nationwid quasi experiment design base variant differ differ approach examin associ long term exposur ambient temperatur mortal risk china analyz effect modif popul characterist socioeconom status data mortal collect communiti across china environment data obtain period estim ci increas mortal risk per c decreas annual temperatur greater effect observ respiratori diseas ci cardiovascular diseas ci younger peopl ci elder ci season analysi per c decreas averag temperatur associ ci ci ci ci mortal chang spring summer autumn winter respect effect long term temperatur total mortal pronounc among communiti low urban low educ attain low gdp per capita total decreas averag temperatur summer decreas mortal risk increas mortal risk season associ modifi demograph characterist socioeconom status find suggest popul disadvantag characterist socioeconom status vulner long term exposur temperatur target polici formul strengthen respons health threat temperatur exposur | D000393;D000397 | T131;T069;T080 |
34,678,391 | influenc polyethylen terephthal microplast biochar co exist paddi soil bacteri communiti structur greenhous gas emiss microplast mp contamin ubiquit agricultur soil cost effect soil amend biochar bc often coincid mp exposur howev littl research conduct regard independ combin effect mps bc soil microbiom n och emiss therefor studi polyethylen terephthal pet wheat straw deriv bc use respect repres mp bc entir rice growth period high throughput sequenc result show pet alon lower bacteri divers pet bc co exist induc appar chang relat abund microb eg cyanobacteria verrucomicrobia bacteroidet associ c n cycl chang phylum class level treatment comparison control treatment bc pet co exist reduc cumul ch emiss respect higher mitig bc pet may result higher soil eh consequ lower methanogenesi function gene mcra abund treat soil addit bc pet alon well combin treatment increas abund nitrif gene enhanc soil nitrif process howev relat contribut nitrif process n emiss possibl lower denitrif n reductas gene nosz found primari gene regul n emiss bc alon increas nosz abund therebi show potenti suppress n emiss contrast bc co ad pet nosz abund lower possibl increas soil aerat thus cumul n emiss higher bc treatment overal result demonstr bc pet function differ soil ecosystem coexist | D000074382;D064307;D012275 | T002;T001;T168;T032;T028;T197 |
34,678,390 | polypharmaci bone fractur risk patient type diabet fukuoka diabet registri prospect investig associ number prescrib drug fractur risk patient type diabet | D003924;D050723;D006620 | T047;T037 |
34,678,388 | promis challeng senolyt skin regener patholog age research last two decad defin crucial role cellular senesc physiolog patholog skin senesc cell detect condit includ develop regener age diseas pathophysiolog cellular senesc skin complex phenotyp senesc pertain sever differ cell type includ fibroblast keratinocyt melanocyt among other paradox transient presenc senesc cell believ benefici context develop wound heal chronic presenc senesc cell detriment context age diseas chronic wound afflict predomin elder identifi strategi prevent senesc induct reduc senesc burden skin could broad benefit age popul senolyt drug known specif elimin senesc cell preserv non senesc cell intens studi use clinic set review recent research skin senesc method detect senesc cell describ promis challeng relat applic senolyt drug articl part special issu senolyt edit joao passo diana jurk | D000375;D015595 | T040;T033;T042 |
34,678,387 | neural tissu microelectrod interact brain micromot electr imped flexibl microelectrod insert insert microelectrod brain recordstimul neuron damag neural tissu blood vessel initi brain wound heal respons due larg differ stiff neural tissu microelectrod brain micromot also lead neural tissu damag associ local immun respons time follow implant brain respons tissu damag result microelectrod failur reduc microelectrod cross section dimens singl digit micron use soft materi elast modulus close neural tissu effect method allevi neural tissu damag enhanc microelectrod longev howev increas electr imped microelectrod caus reduc microelectrod contact site dimens decreas signal nois ratio import reduc dimens also lead reduct critic buckl forc increas microelectrod propens buckl insert discuss brain micromot main sourc neural tissu damag surfac modif microelectrod contact site review key method address increas electr imped issu review focus recent approach aid insert flexibl microelectrod brain includ bend stiff modif effect length reduct applic magnet field pull electrod understand advantag drawback develop strategi offer guid deal buckl phenomenon implant | D001921 | T023 |
34,678,385 | potenti serratia plymuthica iv strain biodegrad polylactid poli ethylen terephthal serratia plymuthica strain iv belong plant growth promot bacteria pgpr sequenc genom plymuthica iv identifi gene involv biodegrad metabol xenobiot potenti plymuthica iv degrad biodegrad aliphat polyest polylactid pla resist biodegrad poli ethylen terephthal pet assess biochem oxygen consumpt bod carbon dioxid method seven day growth bacteria strain show increas respiratori activ presenc pla pet respect assum biodegrad plymuthica iv colonis surfac pla pet sinc format biofilm surfac polym shown livedead method demonstr rela gene alarmon synthetas fold increas express presenc pla fold decreas express presenc pet spot gene hydrolas alarmon research shown bacterium abil biodegrad pla pet first stage process involv bacteri stringent respons gene respons surviv extrem condit | D001673 | T070;T069 |
34,678,382 | synthesi character anti tumor properti benzoylselenoglycol chitosan studi introduc facil method synthes benzoylselenoglycol chitosan high selenium concentr mgg character chemic structur via ftir h nmr c nmr tga xrd analys indic benzoylselenoglycol acid success graft onto c hydroxyl group chitosan anti cancer activ benzoylselenoglycol chitosan investig vitro use hepg cell model result indic excel anticanc activ hepg cancer cell ic valu gml exhibit non toxic normal cell l furthermor mechanist studi reveal benzoylselenoglycol chitosan could induc earli apoptosi gm phase arrest activ caspas activ inhibit hepg cell growth studi led novel organ selenium speci result suggest potenti use effect ingredi cancer prevent therapi food pharmaceut field | D000970;D048271;D012643 | T196;T121;T109;T123 |
34,678,381 | natur polysaccharid base self assembl nanoparticl biomed applic review recent year nanoparticl nps deriv self assembl natur polysaccharid shown great potenti biomed field describ sever self assembl mode natur polysaccharid detail summar natur polysaccharid most use self assembl provid insight current applic achiev self assembl nps one widespread substanc natur natur polysaccharid exhibit advantag biodegrad low immunogen low toxic degrad properti therefor fulli explor applic chitosan hyaluron acid algin starch deriv extens studi especi field biomed polysaccharid base nps prove improv solubl insolubl drug enhanc tissu target abil realiz control sustain releas drug modifi hydrophob group amphiphil polysaccharid self assembl nps driven forc self assembl includ electrostat interact hydrogen bond present polysaccharid base nanoparticl wide appli tumor treatment antibacteri applic gene therapi photodynam therapi transport insulin | D001709;D050997 | T091;T090 |
34,678,380 | fluoresc respons mechan green synthet carboxymethyl chitosan eu aerogel acid gase industri wast acid gase huge hazard environ human health materi detect remov need paper cm chitosan eu fluoresc aerogel prepar via green method combin carboxymethyl chitosan biomass polym eu ion structur properti aerogel character sem tg stress strain curv coordin eu ion carboxymethyl chitosan analyz xps differ luminesc intens aerogel prepar differ ph valu analyz monitor aerogel reveal differ respons differ acid gase fluoresc intens aerogel show linear decreas adsorb hydrogen chlorid gas hcl acet acid gas hac enhanc fluoresc adsorpt system cm chitosan eu aerogel simul use pseudo second order kinet show maximum adsorpt capac hcl mmolg differ respons mechan hcl hac gas analyz ft ir fluoresc lifetim imag judd ofelt theori fluoresc aerogel found potenti applic ensur industri product safeti | D005453 | T070 |
34,678,379 | self coacerv carboxymethyl chitosan ph respons encapsul deliveri strategi carboxymethyl chitosan cmcs base complex coacerv attract much attent drug oral deliveri due ph respons properti uniqu ampholyt polym self coacerv cmcs great research potenti work cmcs self coacerv prepar adjust ph cmcs aqueous solut close isoelectr point fourier transform infrar spectroscopi ftir result reveal electrostat interact hydrogen bond hydrophob interact involv self coacerv cmcs obtain self coacerv present dens surfac structur stabl wide ph rang gradual dissolv basic condit although self coacerv decreas crystallin thermal stabil cmcs obtain coacerv show excel ph respons properti ionic strength stabil also investig potenti lactoferrin lf encapsul oral deliveri cmcs self coacerv exhibit high encapsul effici ee load capac lc addit amount lf mg simul gastric digest result demonstr cmcs self coacerv could protect lf hydrolysi maintain bioactiv lf accord self coacerv cmcs could use ph respons encapsul deliveri strategi | D016503;D006863 | T074;T081 |
34,678,378 | fabric character econom activ packag film base chitosan incorpor pomegran peel antioxid antimicrobi chitosan cs film incorpor differ concentr ww base chitosan pomegran peel powder ppp prepar simpl low cost process character physicochem properti antioxid antibacteri properti film investig result show incorpor ppp increas thick water solubl ws water vapor permeabl wvp opac total phenol content tpc chitosan film decreas moistur content mc mechan properti fourier transform infrar ftir spectroscopi indic format hydrogen bond chitosan ppp addit scan electron microscopi sem analysi present microstructur attribut chitosan film chang enrich pomegran peel film concentr ppp present great ultraviolet visibl light barrier properti moreov antioxid abil film ppp signific increas compar chitosan film addit ppp also promot antibacteri capac control film result reveal incorpor ppp chitosan film could fabric econom activ film antioxid antibacteri properti potenti develop food grade packag materi | D018857;D008567 | T074;T073 |
34,678,376 | investig sex differ effect drug exposur order sensori reward enhanc effect nicotin amphetamin alon combin nicotin enhanc reward effect environment stimuli reward enhanc encourag maintain nicotin consumpt nicotin use preced psychostimul use receiv stimul prescript also predict futur smoke previous studi investig effect drug exposur order reward enhanc nicotin amphetamin thus aim investig drug exposur order impact reward enhanc effect nicotin amphetamin alon combin use male femal spragu dawley rat enhanc investig within subject examin respond maintain visual stimulus reinforc follow pre session inject either amphetamin sal mgkg nicotin sal mgkg twenti rat f complet enhanc test nicotin amphetamin rat f complet test amphetamin nicotin follow phase rat given two pre session inject one amphetamin sal mgkg anoth nicotin sal mgkg experienc amphetamin nicotin increas reward enhanc effect nicotin femal exhibit greater effect amphetamin reward enhanc effect exposur order interact phase receiv nicotin amphetamin enhanc interact nicotin amphetamin femal wherea amphetamin nicotin heighten interact male prior current amphetamin use addit sex consid treat nicotin depend examin factor drive poli substanc use involv nicotin amphetamin keyword adderal adhd dexedrin oper smoke polysubst use | D012054;D012201;D012727 | T061;T032;T041 |
34,678,373 | compar role microplast microalga vector chlorpyrifo bioacumul relat physiolog immun effect mussel microplast mp contamin concern per se also capac sorb dissolv chemic seawat act vehicl transfer marin organ still role mp vehicl contamin associ toxicolog effect poor investig work compar role mp high densiti polyethylen hdpe natur organ particl microalga vehicl chlorpyrifo cpf one common pesticid found river coastal water compar capac mp carri cpf mussel mytilus galloprovinciali expos day dissolv cpf amount cpf load onto mp concentr cpf mussel tissu sever physiolog energet immun paramet analyz day exposur result show similar cpf accumul mussel expos mp spike cpf reveal mp act vector cpf similar way even lesser extent day exposur mussel expos mp spike cpf display similar pronounc biolog effect mussel expos dissolv cpf load cpf suggest combin particl organ contamin effect produc alter biolog respons greater produc stressor alon although evid week exposur | D049872;D004390;D058086 | T131;T204;T109 |
34,678,372 | tempor variat tio engin particl concentr broad river dri wet weather titanium dioxid tio engin particl wide use urban environ pigment paint activ ingredi photocatalyt coat consequ studi necessari quantifi tio engin particl concentr tempor variabl surfac water gain better understand abund environment fate order minim potenti environment impact object studi determin tempor variabl concentr tio engin particl broad river columbia south carolina unit state dri wet weather condit examin relationship flow discharg water qualiti indic concentr tio engin particl tio engin particl concentr broad river water determin mass balanc calcul use bulk titanium concentr increas tinb ratio natur background ratio relat abund singl metal multi metal ti bear particl determin singl particl induct coupl plasma time flight mass spectromet sp icp tof ms addit element ratio tinb tial tife within multi metal ti bear particl determin singl particl level discharg bulk element concentr eg ti al fe nb bulk element ratio eg tial tife tinb tio engin particl concentr turbid display trend rise fall follow storm event linear relationship establish turbid tio engin particl concentr broad river differ flow regim howev correl observ tio engin particl concentr flow discharg dissolv oxygen ph ionic strength establish correl turbid tio engin particl concentr import use translat continu monitor turbid tio concentr | D045483;D014025 | T070;T196 |
34,678,371 | methan emiss china oil natur gas system still unclear review current bottom inventori grow awar concern methan ch emiss china oil natur gas ong system owe carbon neutral target paper aim present comprehens review bottom inventori ch emiss perspect ong system china trend magnitud total emiss last four decad reveal limit current estim explor previous studi show averag ch emiss china ong system almost tripl gg gg trend steadi increas howev estim valu vari order magnitud largest discrep gg discrep unlik caus main incomplet estim sinc domin emiss sourc cover repres studi moreov differ activ level data within rule possibl main contributor larg discrep emiss estim huge variat larg part differ assum emiss factor ef vari order magnitud difficulti determin ef accur due measur base data avail thus larg discrep stem scarciti public avail data enlarg impact various method adopt previous studi better understand ch emiss ong system china measur facil level emiss statist ong infrastructur requir urgent due high cost experi orient measur work intern cooper communic critic prerequisit futur ch emiss estim effect mitig strategi | D008697;D059206 | T167;T109 |
34,678,370 | domin microbi metabol pathway petroleum hydrocarbon soil shale gas field carbon fixat instead co emiss shale gas mine area indigen microorgan degrad organ pollut petroleum hydrocarbon carbon dioxid co water h aerob metabol larg quantiti co emiss exacerb greenhous effect base clean siev soil oil base drill fluid shale gas mine area experi set three concentr gradient mgkg mgkg mgkg treat soil group dispos amount time day analyz dynam chang microbi divers abund key function gene carbon fixat impact petroleum hydrocarbon carbon fixat potenti discov natur attenu law petroleum hydrocarbon contamin soil explor provid scientif research basi ecolog carbon cycl carbon alloc carbon fixat microbi remedi petroleum hydrocarbon contamin soil result obtain indic follow remov rate petroleum hydrocarbon high concentr pollut signific lower low medium concentr pollut tph concentr remov rate group largest earli stage cultur signific correl tph content communiti composit r p ii composit function carbon fixat associ microbiota assess rrna sequenc picrust phylogenet investig communiti reconstruct unobserv state analysi main carbon fixat pathway studi reduct citric acid cycl shortag enzym affect subsequ reaction | D059206;D010578 | T167;T109 |
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