PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
|---|---|---|---|
34,669,594 | health relat factor contribut covid fatal rate various communiti across world factor comorbid age gender distribut most relat hospit number requir intens care case fatal rate review fatal rate coronavirus diseas covid differ popul health background accord comorbid age gender distribut laboratori prognosi covid | D000367;D015897;D012737 | T033;T079;T102 |
34,669,590 | risk factor poor outcom patient coronavirus diseas covid albania studi aim identifi potenti risk factor poor outcom hospit patient sar cov infect albania | D017052 | T080 |
34,669,586 | impact preprocedur biolog marker year mortal syntax trial creatinin clearanc crcl independ determin mortal predict model revascularis outcom complex coronari arteri diseas | D003324;D019161;D062645 | T061;T047;T121;T109 |
34,669,576 | dotfan domain transfer face augment net perform convolut neural network cnn base face recognit model larg reli rich label train data howev expens collect train set larg variat face ident differ pose illumin chang divers within class face imag becom critic issu practic paper propos model assist domain transfer face augment network dotfan generat seri variant input face base knowledg distil exist rich face dataset domain extend stargan architectur dotfan integr two addit subnetwork ie face expert model fem face shape regressor fsr latent facial code control fsr aim extract face attribut fem design captur face ident aid dotfan separ learn facial featur code effect generat face imag various facial attribut keep ident augment face unalt experi show dotfan benefici augment small face dataset improv within class divers better face recognit model learn augment dataset | D000465;D000066499 | T170;T041 |
34,669,574 | associ obstruct sleep apnea total sleep time health relat qualiti life children undergo routin polysomnographi promi approach obstruct sleep apnea osa negat impact health relat qualiti life hr qol adult pediatr studi explor relationship relationship hr qol domain | D011788;D020181 | T047;T078 |
34,669,570 | underrecognit sleep disord breath common health condit west virginia medicaid popul driver poor health outcom assess preval rate sleep disord breath sdb high risk rural dwell medicaid popul signific comorbid | D008484;D012891 | T047;T089;T064 |
34,669,569 | breath rate variabl obstruct sleep apnea wake obstruct sleep apnea osa defin paus breath sleep daytim breath dysregul may also present sleep may unmask breath instabl osa usual mask behavior influenc wake breath hold bh challeng use demonstr breath instabl one measur breath stabil breath rate variabl brv aim assess brv rest respons bh osa | D020181;D014851 | T047;T041 |
34,669,568 | asthma phenotyp covid risk popul base observ studi rational studi suggest patient asthma risk sever coronavirus diseas covid limit data asthma phenotyp consid risk specif covid object determin effect asthma phenotyp three level covid outcom compar hospit rate influenza pneumonia method electron medic record use identifi patient asthma match general popul patient level data link public health england sever acut respiratori syndrom coronavirus sar cov test data hospit mortal data asthma phenotyp medic exacerb histori type inflamm risk outcom adjust major risk factor measur use cox regress measur main result total patient asthma match patient includ patient asthma signific increas risk general practic diagnosi covid asthma regular inhal corticosteroid ic use hazard ratio hr confid interv ci intermitt ic plus add asthma medic use hr ci regular ic plus add use hr ci frequent exacerb hr ci signific associ hospit phenotyp signific associ influenza pneumonia hospit patient regular ic plus add asthma therapi hr ci frequent exacerb hr ci signific higher risk icu admiss death atopi blood eosinophil count associ sever covid outcom conclus sever asthma associ sever covid outcom type inflamm risk covid hospit appear similar risk influenza pneumonia | D010641;D000086402 | T032;T005 |
34,669,566 | preval factor associ food insecur among older adult sub saharan africa systemat review food insecur undermin health well grow number older adult sub saharan africa review aim examin preval food insecur relat contribut factor food insecur among older adult sub saharan africa use pubm scopus sciencedirect web scienc core collect search engin includ articl data extract preval sever moder food insecur household older adult rang respect various socio econom eg low educ level widow low incom lower wealth posit household live rental hous live rural area lack social grant pension demograph eg femal black racial group larger famili size health nutrit status relat eg self report poor health status function mobil relat disabl psycholog disord factor influenc food insecur older adult sub saharan africa find review help stakehold priorit issu food insecur design implement polici program improv food secur among older adult sub saharan africa | D005191;D000084884 | T079;T098;T099;T169;T033;T062;T102 |
34,669,562 | mortal leukemia cancer heart diseas among us nuclear power plant worker aim million person studi low dose health effect mps examin level radiat risk chronic exposur receiv gradual time acut case japanes atom bomb survivor nuclear power plant npp worker compris near percent mps leukemia select cancer parkinson diseas ischem heart diseas ihd caus death evalu | D006331;D007938;D015451;D008175;D016273;D010300 | T191;T047;T037 |
34,669,558 | soft sensor model pichia pastori cell concentr base ibda relm pichia pastori ferment process multi oper condit difficult predict cell concentr new oper condit soft sensor model establish specif oper condit inspir idea transfer learn method base improv balanc distribut adapt regular extrem learn machin ibda relm propos solv problem domain adapt da method transfer learn develop reduc distribut distanc transform data howev joint distribut adapt jda balanc distribut adapt bda da direct appli regress problem fuzzi set fss method propos solv issu final soft sensor model pichia pastori cell concentr realiz input convert data relm model simul verif carri three oper condit scene ferment transfer effect three da method includ transfer compon analysi tca improv joint distribut adapt ijda well ibda compar predict result show ibda relm better perform soft sensor pichia pastori cell concentr multi oper condit | D010843;D004718 | T004 |
34,669,557 | locat electrod tympan membran matter record electrocochleographi non invas tympan electrocochleographi tm ecochg use clinic diagnos nevertheless influenc electrod locat tympan membran tm ecochg result need studi | D004566;D014432 | T023;T073 |
34,669,556 | earli chang patient access interv covid pandem background covid first report unit state januari spread throughout countri requir em system rapid adapt patient need protect em personnel em agenc develop protocol requir personnel enhanc person protect equip prior patient contact hypothes patient access interv pai defin time wheel stop scene initi patient contact increas covid pandem potenti affect patient outcom particular time sensit emerg cardiac arrest respiratori distress method retrospect cohort studi use commerci ambul data four largest citi connecticut two differ time point pre covid march may covid march may pai calcul contemporan report scene time total case analyz sub analys perform call locat extend care facil ecf emerg echodelta call medic cardiac arrest call result total case evalu case includ necessari time data pai remov yield total case averag pai increas minut second ms pre covid ms covid ecf pai increas ms ms echodelta pai increas ms ms medic cardiac arrest pai increas ms ms ecf cardiac arrest pai increas ms ms comparison p conclus statist signific increas studi pai covid second increas pai call may clinic signific case howev life threaten patient present increas may particular relev increas pai compound ecf environ possibl due state mandat screen temperatur check em personnel enter facil highlight ecf cardiac arrest data demonstr clinic signific increas pai ms studi limit accuraci contemporan time report em result support hypothesi pai increas covid pandem | D000086382;D004632;D006323 | T047;T046;T093;T061;T067;T058 |
34,669,553 | model influenc extract paramet yield chemic characterist microwav extract mango mangifera indica l peel pectin respons surfac methodolog extract consid critic unit oper recov bioactiv compound situ state mani plant base food process wast characterist pectin predict vari sourc raw materi extract post extract condit studi focus investig optim condit extract mango peel pectin mpp increas yield qualiti microwav assist extract mae box behnken experiment design use model influenc extract paramet microwav power ph time respons yield esterif degre equival weight anhydrouron acid methoxyl content pectin predict model adequ fit experiment data p respons variabl higher yield pectin better qualiti obtain optim condit microwav power watt w extract time min ph mpp obtain categor low methoxyl pectin rang degre esterif de possibl treatment variat remain studi reveal mango peel effect altern sourc pectin could extract microwav method larg scale | D031022 | T002;T168 |
34,669,550 | em experi care communic patient famili life limit ill introduct emerg medic servic em system design reduc death disabl em train focus save live resuscit aggress treatment transport emerg depart em provid common care patient life limit ill object explor em provid challeng self perceiv role train experi care patient famili life limit ill method qualit content analysi semi structur interview em provid n alameda counti ca purpos sampl use ensur varieti perspect includ provid age year em experi emerg medic technician paramed fire base versus privat transport versus non transport record transcrib interview analyz use themat approach result work patient life limit ill particip em provid interview report challeng formal train prepar respond grief emot express famili traumat event death notif perform moment decis make determin cours action acut unexpect traumat event mani particip report becom comfort grief counsel death notif acquir clinic experi moment decis make eas patient famili advanc care plan discuss howev mani patient especi vulner underserv popul lack advanc care plan face situat cours action immedi clear em provid voic two frame role care patient life limit ill transport transport peopl versus holist view em provid provid counsel inform avail resourc conclus em provid interfac patient life limit ill famili set traumat event cours action often unclear opportun provid formal train em provid around grief counsel well assist patient famili moment decis make support previous identifi goal align care patient goal prefer | D004632;D004634 | T058;T097;T093;T061 |
34,669,549 | million person million dream vision nation center radiat epidemiolog biolog epidemiolog studi radiat expos popul form basi human safeti standard also help shape public health polici evid base health practic identifi quantifi health risk exposur defin popul centuri epidemiologist studi consequ radiat exposur yet health effect low level deliv low dose rate remain equivoc | D054043;D000069079 | T037;T052;T073 |
34,669,548 | associ marit violenc reproduct sexual health outcom women multi countri studi south asia studi examin relationship marit violenc mv reproduct sexual health outcom women bangladesh india nepal pakistan lifetim mv inflict husband wive highest bangladesh india pakistan nepal respect overal result studi suggest mv perpetr husband wife signific associ unintend pregnanc pregnanc termin current use modern contracept method sexual transmit infect inconsist associ appear across countri lifetim sexual violenc physic sexual forc signific posit associ unintend pregnanc pregnanc termin respect wherea type mv signific posit relat symptom sexual transmit diseas women appropri measur undertaken combat violenc women vaw necessari servic provid victim women uphold reproduct sexual right | D012725;D012749 | T032;T047;T053;T055 |
34,669,545 | asntr ventur hybrid confer lesson learn covid pandem th american societi neural therapi repair asntr return sheraton sand key clearwat beach florida month hiatus like near confer pandem asntr confer held person offer virtual option event format advantag travel restrict person constraint lack spontan person connect highlight meet includ return bernard sanberg memori award roy bakay memori lectur presidenti lectur given gabriel de erausquin discuss possibl long term cns effect result sar cov infect virtual person event includ oral poster present asntr manag maintain uniqu essenc small import meet | D003226 | T170;T073;T068 |
34,669,543 | invert urotheli papilloma cat year old neuter femal cat refer clinic sign refer lower urinari tract diseas clinic examin reveal tens pain urinari bladder proxim urethr thicken endoscop studi show peduncul mass polypoid project multipl full thick mucos biopsi obtain mass almost complet excis neoplasm confin mucosa consist epitheli cell arrang anastomos trabecula nest grow downward lamina propria neoplast cell show minim atypia low mitot activ histolog find consist invert urotheli papilloma felin papillomavirus dna amplifi biopsi one year later cat urolog sign urinari bladder normal ultrasound author knowledg first report case invert urotheli papilloma cat differenti diagnosi low grade urotheli carcinoma lesion invert growth pattern | D002295;D002371;D018308;D001749 | T191;T047 |
34,669,540 | self percept age depress symptom mediat role loneli object depress major health concern individu societi henc understand risk factor depress import individu grow older way perceiv age process may signific influenc physic mental health negat percept age could put individu risk social withdraw caus loneli result higher level depress symptom method use health retir survey larg longitudin dataset span period year examin model loneli mediat relationship self percept age depress symptom result find suggest loneli inde mediat relationship self percept age depress symptom conclus result highlight import way peopl view age process shape social mental well practition may want address self percept age help older adult cope loneli depress symptom | D003863;D008132 | T033;T048;T184 |
34,669,538 | giant epiderm nevus face treat co dye laser combin case report literatur review epiderm nevi en cutan hamartoma present birth usual occur trunk face limb appear patch overgrow skin may small local may interest extens area bodi year old man came attent en interest face treatment protocol consist session co laser order vapor thicker area follow session dye laser area prevent scar treatment perform local anesthesia sedat three surgic session space month two session dye laser space apart month perform follow improv esthet outcom patient follow year recurr although surgeri still consid gold standard en manag alway feasibl novel combin techniqu obtain optim cosmet result relaps within period follow although trial signific number patient requir combin co dye laser promis becom valid therapeut altern treat giant en face | D053685;D054025;D009506 | T191;T074;T061 |
34,669,535 | preval sever base classif sensori process issu exploratori studi neuropsycholog implic sensori process issu main known sensori process disord spd frequent children neurodevelopment disord associ learn behavior difficulti howev previous studi suggest disturb might also present typic develop children reach preval rate nevertheless publish studi primari conduct non european countri therefor aim first object explor frequenc sensori process difficulti random sampl school age children spain contribut studi preval sensori profil sp assess tool administ particip studi sensori process pattern absenc presenc sensori process issu affect sensori system well socioemot attent behavior impact furthermor second object develop novel strategi classifi spd sever rang use sp yield result accord sampl classifi follow alter mild moder sever sensori process alter result show preval rate consist previous find particip met sever alter criteria classifi moder mild alter respect final hypothes spd under neuropsycholog process might associ condit result highlight necess research effort establish whether high frequenc sever rate sensori process alter link neuropsycholog variabl provid classif system might use determin associ | D065886;D012678 | T048;T047 |
34,669,534 | effect esophagogastroduodenoscopi chang treatment outcom refractori gastro esophag reflux diseas effect screen esophagogastroduodenoscopi egd refractori gastroesophag reflux diseas gerd symptom alon valid | D005764 | T047 |
34,669,532 | parent implement embed aac intervent teach navig request communic function children autism spectrum disord studi evalu effect embed naturalist intervent teach augment altern communic aac applic respons three preschool age male autism spectrum disord asd parent taught emb opportun child communic grid base aac applic everi day routin play mealtim communic target includ request object use two step taxonom navig respons request assist reject item make social commentsrespons use two step messag strip respons intervent parent use strategi time delay prompt reinforc devic proxim fade time encourag target respons display format intervent target select consider prior dynam assess result effect intervent evalu use multipl probe across particip design function navig aac item request three particip show immedi increas respond maintain high level function aac respond communic purpos also increas gradual pace three particip show general respond new item ad display display page larger array folder vocabulari item introduc general label task mix | D000067877;D003143;D003147 | T048;T074;T066;T073 |
34,669,529 | smoke tobacco associ renal hyperfiltr tobacco consumpt renal risk factor effect estim glomerular filtrat rate egfr remain unclear aim evalu possibl impact use tobacco product smoke snus egfr base creatinin cystatin c use first cohort particip second cohort particip none pre exist renal diseas subject donat blood sampl complet questionnair includ question tobacco use assess effect egfr hierarch multipl linear regress model use activ smoke associ independ higher egfr creatinin subject p analys stratifi sex show similar find men p women p egfr cystatin c signific associ activ smoke subject p associ seen stratif sex snus associ egfr conclus smoke associ signific higher egfr creatinin mechan may renal hyperfiltr smaller molecul creatinin probabl caus substanc smoke tobacco nicotin effect seen snus | D014026;D062789 | T131;T002;T073;T109 |
34,669,526 | hysteroscop find laparoscop open myomectomi without uterin caviti breach histor cohort studi aim studi evalu hysteroscop find laparoscop laparotom myomectomi focus presenc postop intrauterin adhes group patient without periop uterin caviti breach ucb | D010535;D007889;D014591;D063186;D014594 | T061;T191;T047;T060 |
34,669,525 | skin impact exposur ultraviolet visibl infrar artifici light review social distanc conduc grow impact artifici light daili life worldwid popul report consequ skin sunlight also essenti human develop inde solar radiat compos differ type wavelength generat differ skin effect divid ultraviolet uv infrar ir visibl uv radiat uva uvb cutan biolog effect rang photoag immunosuppress melanoma format product reactiv oxygen speci ros inflamm elev energi state organ molecul chang dna structur ir radiat reach deeper layer skin also relat generat ros photoag erythema visibl light respons generat ros pigment cytokin format matrix metallopeptidas mmps furthermor artifici light could harm skin generat ros hyperpigment stimul photoag current briefli summar cutan biolog effect sunlight well artifici light skin remark opportun evolut current photoprotect formula new strategi broad spectrum protect | D012867;D013473 | T167;T022 |
34,669,523 | staff physician protect neurointervent coronavirus diseas pandem summari review recommend coronavirus diseas pandem caus novel sever acut respiratori distress syndrom coronavirus date result estim global death toll million million report case worldwid becom increas clear deliveri effect neurointervent clinic care mean maintain abl safe workforc rapid chang environ staff physician protect becom increas topic relev within angiographi suit peripher cardiac intervent neurointervent follow review outlin type person protect equip relev neurointervent care summaris societi guidelin make recommend provis safe care staff patient | D000086382;D010820 | T097;T047;T067 |
34,669,521 | new therapeut target biomark acut graft versus host diseas gvhd acut graft versus host diseas gvhd major toxic allogen hematopoiet cell transplant hct system steroid standard primari treatment half patient respond complet surviv steroid refractori patient poor gastrointestin gi tract key target organ usual determin patient respons therapi | D006086;D018380 | T047;T061 |
34,669,516 | comparison sexual function male patient anorect malform convent laparoscop approach aim compar incid erectil dysfunct ejaculatori anomali male patient anorect malform arm treatment sacroperin approach group laparoscop assist anorectoplasti laarp group l method male patient underw repair high intermedi type arm center age year novemb enrol patient intellectu disabl chromosom disord exclud sacroperin anorectoplasti long routin perform hospit laarp introduc standard procedur medic record outpati clinic retrospect review questionnair sent novemb data regard erectil dysfunct ejaculatori anomali associ anomali collect compar two group result answer obtain patient group patient group l patient characterist similar median age time repli signific differ year group year group l p none patient erectil dysfunct patient group patient group l ejaculatori failur signific differ two group conclus incid sexual dysfunct male patient arm might higher healthi popul patient might abscond follow visit age therefor provid patient accur inform issu puberti essenti | D000071056;D010535 | T190;T061;T019;T060 |
34,669,515 | breastfeed associ childhood obes bodi composit find racial divers matern child cohort background studi suggest breastfeed lower obes risk childhood generaliz exist evid limit examin associ breastfeed childhood overweight obes percentag bodi fat racial divers matern child cohort method cross section studi includ children age year enrol environment exposur child health outcom echo cohort subset nation institut child health human develop fetal growth studi cohort logist regress use estim odd ratio confid interv cis overweight bmi kgm th th percentil obes bmi th percentil relat breastfeed includ durat exclus total breastfeed linear regress use evalu associ breastfeed percentag bodi fat measur bioelectr imped analysi result fifti two percent children male non hispan black hispan non hispan white asian overweight obes six month exclus breastfeed compar breastfeed associ lower odd obes ci adjust age gender race socioeconom status matern bmi child activ percentag bodi fat invers associ breastfeed durat none month exclus breastfeed adjust mean percentag bodi fat respect result differ gender raceethn matern bmi status conclus exclus breastfeed first month life invers signific associ obes percentag bodi fat age year find support current breastfeed guidelin | D001942;D063766 | T047;T055;T058;T040;T033 |
34,669,512 | function effect cardiomyocyt injuri covid covid affect multipl organ clinic data mount sinai health system show substanti number covid patient without prior heart diseas develop cardiac dysfunct covid patient develop cardiac diseas known integr cell biolog physiolog analys human cardiomyocyt differenti human induc pluripot stem cell hipsc infect sever acut respiratori syndrom coronavirus sar cov presenc interleukin il clinic find relat laboratori valu covid patient identifi plausibl mechan cardiac diseas covid patient infect hipsc deriv cardiomyocyt healthi human subject sar cov absenc presenc il il infect result increas number multinucl cell interleukin treatment infect result disorgan myofibril extracellular releas troponin reduc errat beat infect result decreas express mrna encod key protein cardiomyocyt contractil apparatus although interleukin increas extent infect increas contractil dysfunct associ viral infect cardiomyocyt result cessat beat clinic data hospit patient mount sinai health system show signific portion covid patient without histori heart diseas elev troponin interleukin level substanti subset patient show reduc left ventricular function echocardiographi laboratori observ combin clinic data indic direct effect cardiomyocyt interleukin sar cov infect might underli heart diseas covid patient import sar cov infect multipl organ includ heart analys hospit patient show substanti number without prior indic heart diseas comorbid show signific injuri heart tissu assess increas level troponin blood studi cell biolog physiolog effect virus infect healthi human ipsc deriv cardiomyocyt cultur virus infect interleukin disorgan myofibril increas cell size number multinucl cell suppress express protein contractil apparatus viral infect cardiomyocyt cultur trigger releas troponin similar elev level covid patient heart diseas viral infect presenc interleukin slow desynchron beat cardiomyocyt cultur cell level physiolog chang similar decreas left ventricular eject seen imag patient heart observ suggest direct injuri heart tissu virus one under caus heart diseas covid | D057026;D032383 | T025 |
34,669,511 | cross speci meta analysi transcriptom chang morula blastocyst transit metabol physiolog chang take center stage morula blastocyst transit mbt culmin format inner cell mass icm trophectoderm te lineag recent studi identifi signal pathway drive lineag specif featur pathway display signific speci diverg better understand evolutionari conserv mbt complet meta analysi rna sequenc data five model speci icmt differ four speci although mani gene chang express mbt within given speci number share differenti express gene deg compar small number share icmt deg even smaller deg relat known lineag determin pathway eg pouf seen promin pathway function associ share deg share across individu speci deg list impact basic physiolog metabol activ tca cycl unfold protein respons oxid phosphoryl sirtuin signal mitot role polo like kinas nrf mediat oxid stress estrogen receptor signal apoptosi necrosi lipid fatti acid metabol cholesterol biosynthesi endocytosi ampk signal homeostasi transcript cell death also observ promin differ transcriptom regul ungul nonungul particular icm te enhanc mrnas result extend understand share mechan mbt format icm te better inform select model speci particular applic | D059467 | T086;T081 |
34,669,508 | hyperhomocysteinemia promot carotid arteri damag newli diagnos type diabet patient without hypercholesterolemia background relationship serum homocystein level carotid arteri damag subject newli diagnos type diabet mellitus remain unclear effect hyperhomocysteinemia hhci carotid arteri damag patient differ cholesterol level need investig method total newli diagnos type diabet beij chaoyang hospit recruit studi patient divid four group accord level serum homocystein cholesterol carotid arteri damag defin thicken intima media andor plaqu format result subject patient hhci incid carotid arteri injuri signific lower diabet patient normal homocystein level nonhypercholesterolemia spearman correl analysi show homocystein posit correl free fatti acid negat correl glucos metabol paramet logist regress show hhci correl carotid arteri injuri adjust tradit cerebrovascular risk factor type diabet without hypercholesterolemia odd risk p wherea hhci associ carotid arteri injuri either total studi popul hypercholesterolemia subgroup conclus hhci correl carotid arteri damag newli diagnos type diabet subject without hypercholesterolemia improv advers vascular outcom mediat hhci diabet patient need investig | D003924;D006937;D020138 | T047 |
34,669,505 | feed state depend modul feed relat motor pattern studi elucid modul microcircuit activ isol nervous system reveal numer insight regard neural circuit flexibl approach limit link experiment result behavior context bridg gap studi feed behavior link modul microcircuit activ isol stomatogastr nervous system stns male cancer boreali crab specif remov hemolymph crab unf h unf hemolymph fed min h hemolymph remov fed hemolymph feed first signific foregut empti occur h later complet empti requir h appli unf fed hemolymph stomatogastr ganglion stg isol stns prepar separ unf crab determin influenc vcn ventral cardiac neuron trigger gastric mill chew pylor filter chew food rhythm unf hemolymph littl influenc rhythm fed hemolymph examin time point min h h feed slow one rhythm without weaken circuit neuron activ also distinct paramet chang associ time point one chang uniqu h time point ie reduc activ one circuit neuron transit gastric mill retract protract phase suggest fed hemolymph also enhanc influenc project neuron innerv stg ganglion isol appli hemolymph hemolymph thus provid feed state depend modul two feed relat motor pattern c boreali stg new noteworthi littl known behavior link modul microcircuit activ show vcn trigger gastric mill chew pylor food filter rhythm isol crab cancer boreali stomatogastr nervous system chang appli hemolymph recent fed unf crab includ distinct paramet chang examin post fed hemolymph time point result suggest presenc feed relat chang circul hormon regul consummatori microcircuit activ | D004068;D010507 | T042;T079 |
34,669,501 | nigeria stillbirth newborn death increas covid pandem covid pandem put sever pressur health care system worldwid although attent focus covid hospit death expert warn potenti devast secondari health effect effect may sever low middl incom countri alreadi weak health care system studi examin effect covid pandem earli infant death question current unsettl present new evid nigeria show earli infant death signific increas pandem use data birth outcom larg divers cohort pregnant women enrol prospect studi quasi experiment differ differ design found percentag point percent increas percentag point percent increas respect stillbirth newborn death find show health effect pandem extend beyond count covid death find general low middl incom countri may indic hard gain child surviv made past two decad risk revers amid ongo pandem polici address disrupt health servic deliveri provid support vulner group specif household pregnant women critic pandem continu | D000086382;D058873 | T047;T067 |
34,669,500 | tempor spatial evolut various function neuron demyelin induc cuprizon multipl sclerosi ms inflammatori demyelin neurodegen diseas central nervous system cns report tempor spatial evolut various function neuron demyelin cuprizon cpz induc mous model cpz signific induc damag axon neuron wk feed howev wk cpz feed axon neuron mark reduc cortex posterior thalam nuclear group hippocampus simultan express tph tryptophan neuron vglut glutam neuron obvious decreas express th dopaminerg neuron slight decreas tail part substantia nigra striatum wherea number chat cholinerg neuron signific differ brain second week feed cpz caus higher level glutam secret upregul express eaat astrocyt contribut rapid suffici glutam uptak remov find reveal astrocyt driven glutam reuptak protect cns excitotox rapid reuptak glutam wk cpz feed stage although ng oligodendroglia progenitor cell opc enhanc demyelin foci myelin sheath still absent conclus comprehens observ tempor spatial evolut various function neuron result assist understand demyelin affect neuron cpz induc demyelin provid novel inform neuroprotect myelin regener demyelin diseas new noteworthi result indic tempor spatial evolut various function neuron demyelin cuprizon cpz induc mous model main occur wk cpz feed time axon compart damag consequ neuron death occur glutam neuron lost obvious astrocyt mediat glutam reuptak could protect neuron excitatori effect glutam | D001253;D003711;D009186;D009474 | T047;T025;T026;T046;T024 |
34,669,498 | reliabl rang motion measur healthi dog examin walk treadmil determin reliabl rang motion rom measur describ physiolog differ rom habitu effect gait analysi healthi dog walk treadmil | D005684;D016138 | T033;T169;T056 |
34,669,497 | compar evalu tomosynthesi comput tomographi magnet reson imag find metacarpophalang joint equin cadav describ techniqu assess diagnost potenti limit tomosynthesi imag metacarpophalang joint mcpj equin cadav compar tomosynthesi appear patholog lesion convent radiograph ct mri appear evalu imag find gross lesion given mcpj | D006734;D050279 | T023;T047 |
34,669,496 | quantif renal relax rate use blood oxygen level depend magnet reson imag furosemid administr healthi beagl assess feasibl blood oxygen level depend bold mri measur renal relax rate r proxi renal oxygen furosemid administr evalu reliabl repeat measur healthi dog | D005665;D010100 | T196;T121;T109;T123 |
34,669,495 | effect leukoreduct n methylhistamin concentr store unit canin whole blood determin effect leukoreduct n methylhistamin nmh stabl histamin metabolit concentr unit canin whole blood storag incub room temperatur approx c simul temperatur condit transfus | D001793;D004912 | T025;T061 |
34,669,494 | vivo confoc microscop featur natur acquir canin herpesvirus felin herpesvirus dendrit punctat ulcer kerat describ vivo confoc microscopi ivcm featur corneal epithelium stroma dog cat herpet dendrit ulcer kerat | D002371;D003320;D004283;D002184 | T047;T005 |
34,669,493 | evalu effect dexmedetomidin midazolam ketamin combin administ intramuscular captiv red foot tortois chelonoidi carbonaria evalu effect dexmedetomidin midazolam ketamin dmk combin administ im captiv red foot tortois chelonoidi carbonaria | D020927;D007649;D014426 | T121;T014;T109 |
34,669,492 | evalu canin adipos deriv multipot stromal cell differenti ligamentoblast tension collagen type templat custom bioreactor cultur system evalu differenti canin adipos deriv multipot stromal cell asc ligamentoblast tension collagen type col templat perfus cultur system | D000273;D024042 | T123;T116;T024;T201 |
34,669,491 | pharmacokinet grapipr administ red tail hawk buteo jamaicensi food withheld hour identifi oral dose grapipr red tail hawk rthas buteo jamaicensi would achiev plasma concentr ngml consid therapeut dog osteoarthr | D046428 | T012 |
34,669,489 | investig influenc manual ventil control respir right ventricular pressur volum loop echocardiograph variabl healthi anesthet dog evalu influenc manual ventil control respir right ventricular rv pressur volum loop deriv echocardiograph variabl dog | D004283;D018497 | T047;T046 |
34,669,488 | evalu glucos absorpt rate follow intracoelom subcutan administr experiment dehydr inland beard dragon pogona vitticep evalu glucos absorpt rate indirect measur fluid absorpt sc intracoelom ice administr dextros solut experiment dehydr inland beard dragon pogona vitticep | D008116 | T014 |
34,669,487 | guid therapi select rheumatoid arthriti use molecular signatur respons classifi assess budget impact clinic util background patient moder sever rheumatoid arthriti ra treat rang target therapi follow inadequ respons convent synthet diseas modifi antirheumat drug methotrex wherea clinic practic guidelin provid formal recommend initi target therapi tumor necrosi factor alpha inhibitor tnfi class preval first line select base clinician experi safeti profil andor formulari requir also costliest patient achiev adequ clinic respons first line tnfi howev molecular signatur respons classifi msrc test assess ra relat biomark identifi patient unlik achiev adequ respons tnfi class therapi object model cost effect msrc guid first line target therapi select compar current standard care method budget impact analysi use data sourc august septemb preval first line target therapi obtain use market intellig datamonitorinforma plc rheumatolog dashboard forecast averag first year cost treatment class calcul use wholesal acquisit cost ibm micromedex red book onlin averag effect class base manufactur report acr respons rate american colleg rheumatolog adequ respons criteria improv month therapi initi impact msrc test first therapi select predict base third parti generat decis impact studi analyz potenti alter rheumatologist prescrib pattern receiv msrc test report sensit analysi evalu potenti impact variat first year medic cost adher msrc report test price first year cost treatment cost respons first year therapi cost therapi divid probabl achiev acr compar standard care msrc guid care result estim cost first year standard care treatment patient initi treatment tnfi cost achiev acr respons appli msrc guid patient stratif therapi select first year cost net test price patient initi tnfi first year msrc guid care cost includ test price estim improv standard care sensit analysi show net cost improv guid care vs standard care across scenario patient predict inadequ tnfi respond model lower price altern predict show increas acr respons rate msrc test result indic first line tnfi predict show acr respons rate superior class model implement clinic msrc guid care might save us health care system million annual improv acr conclus precis medicin use msrc guid patient stratif therapi select may decreas cost improv efficaci target ra therapi disclosur work fund full scipher medicin corpor particip data analysi interpret draft review approv public author contribut data analysi interpret public prepar maintain control final content arnel wither connolli strong employe stock ownership scipher medicin corpor bergman receiv consult fee abbvi gilead glaxosmithklin novarti pfizer regeneron sanofi scipher medicin own stock stock option johnson johnson kenney logan lim harashima consult scipher medicin corpor basu noth disclos | D002017;D003362;D016896 | T080;T170;T057;T081 |
34,669,486 | real time intraop ureter identif minim invas colorect surgeri systemat review background although colorect surgeri crs current almost entir standard surgic procedur still show pitfal intraop ureter injuri intraop ureter identif iui could reduc ureter injuri rate evid still lack aim analyz util effect real time iui minim invas crs materi method systemat review perform examin avail data random nonrandom studi evalu util intraureter fluoresc dye ifd light ureter stent lus intraop identif uret crs accord prefer report item systemat review meta analys prisma standard primari endpoint ureter injuri rate secondari endpoint includ acut kidney injuri hematuria urinari tract infect uti fluoresc assess result literatur search studi record studi underw full text review studi met inclus criteria overal total patient success receiv iui patient experienc ureter injuri hematuria report patient follow lus guid surgeri patient follow ifd guid surgeri although transient case uti report lus guid resect ifd guid resect acut kidney injuri occur lus guid surgeri ifd guid surgeri conclus real time ureter identif techniqu could repres valid solut complex minim invas crs safe time consum alway reproduc surgeon prospect studi need confirm find | D058186;D003107;D014513 | T091;T023;T047;T037 |
34,669,485 | epidur spinal cord stimul intervent motor recoveri motor complet spinal cord injuri spinal cord injuri sci common result perman loss motor sensori autonom function recent clinic studi shown epidur spinal cord stimul may provid benefici adjunct restor lower extrem neurolog function herein review recent clinic advanc lumbosacr epidur stimul restor sensorimotor function individu motor complet sci discuss putat neural pathway involv promis neurorehabilit approach focus three main section review recent clinic result locomotor restor complet sci discuss contemporari understand electr neuromodul signal transduct pathway involv spinal locomotor network review current challeng motor system modul futur direct toward integr neurorestor current understand initi depolar occur level larg diamet dorsal root propriocept affer integr interneuron latent residu supraspin translesion connect recruit locomotor center augment downstream motor unit spinal epidur stimul initi excit chang spinal network supraspin network differ stimul paramet facilit stand step may also potenti augment myriad sensorimotor autonom function comprehens investig mechan mediat transform dysfunct spinal network higher function state greater focus integr system base control system may reveal key mechan under neurolog augment motor restor sever paralysi | D000066530;D062187 | T061 |
34,669,460 | multicent evalu attenu total reflect fourier transform infrar atr ftir spectroscopi base method rapid identif clinic relev yeast fourier transform infrar ftir spectroscopi demonstr applic reagent free whole organ fingerprint techniqu microbi identif strain type routin applic techniqu microbiolog laboratori acquisit ftir spectra attenu total reflect atr mode simplifi ftir spectroscopi workflow provid result within minut initi cultur without prior sampl prepar previous central work correct speci identif clinic relev yeast achiev employ atr ftir base method spectral databas develop group studi atr ftir spectromet place clinic microbiolog laboratori month period use collect spectra routin yeast isol site identif speci level identif result compar obtain convent biochem test andor matrix assist laser desorptionion time flight mass spectrometri isol produc discord result reanalyz routin identif method atr ftir spectroscopi pcr gene sequenc dd intern transcrib spacer region among routin clinic yeast isol collect identifi atr ftir base method isol correct identifi speci level remain isol inconclus misidentif due low preval candida auri routin isol addit random select c auri n isol obtain evalu result correct identif overal data obtain multicent evalu studi use multipl spectromet system oper indic atr ftir spectroscopi reliabl cost effect yeast identif techniqu provid accur time minsampl speci identif prompt initi cultur | D015003 | T004 |
34,669,459 | select cultur medium screen fosfomycin resist enterobacteral select medium screen fosfomycin fos resist enterobacteral develop perform medium first evalu use cultur collect enterobacteri clinic strain fos suscept fos resist superfo medium show excel sensit specif detect condit test spike stool spike urin specimen reveal excel perform lower limit identif rang cfuml screen medium allow easi accur detect fos resist isol regardless resist mechan | D005578 | T195;T109 |
34,669,458 | manag cytomegalovirus epstein barr virus hiv viral load qualiti control data use uniti real time qualiti control qc rule westgard rule appli viral load test identifi run review repeat requir balanc patient safeti benefit error detect cost ineffici fals reject studi identifi total allow error tea literatur util commerci avail softwar program uniti real time bio rad laboratori manag qc data assess assay perform provid qc decis support fda approvedclear abbott cytomegalovirus cmv hiv viral load well laboratori develop epstein barr virus ebv viral load assay uniti real time use calcul mean standard deviat sds coeffici variat cv percent negat low posit high posit control data day test sigma valu calcul measur test perform relat tea log sigma valu ebv predict erron result per million individu patient test frequenc wherea sigma valu cmv hiv indic erron result per million individu patient test uniti real time qc design modul util sigma valu recommend qc rule provid object evid loosen laboratori exist qc rule run accept potenti reduc fals reject rate fold assay variat ebv viral load studi provid framework laboratori uniti real time tool evalu assay perform relat clinic decis point establish optim rule routin monitor molecular viral load assay perform | D020031;D015658 | T047 |
34,669,457 | viral cultur confirm sar cov subgenom rna valu good surrog marker infect determin sar cov viral infect crucial patient clinic assess isol decis assess subgenom rna sgrna surrog marker sar cov infect sar cov posit revers transcript pcr rt pcr respiratori sampl n comparison viral cultur refer standard virus replic sgrna viral isol result concord case indic high signific agreement two techniqu cohen kappa coeffici confid interv ci p sgrna rt pcr show sensit posit predict valu detect replic compet virus support sgrna surrog marker sar cov infect sgrna rt pcr accur rapid afford techniqu overcom cultur cycl threshold ct valu limit routin implement hospit laboratori detect viral infect essenti optim patient monitor efficaci treatmentsvaccin work reincorpor polici well safe shorten isol precaut | D000086382;D000086402 | T047;T005;T067 |
34,669,456 | use molecular method detect shigella infer phenotyp resist shigella treatment studi molecular diagnost method improv detect shigella yet abil detect shigella drug resist direct stool specimen less clear test stool specimen shigella treatment studi bangladesh includ cultur posit stool specimen pair shigella isol util taqman array card includ quantit pcr qpcr assay enteropathogen antimicrobi resist amr gene shigella detect cultur stool specimen qpcr detect shigella diarrhea associ quantiti p sensit specif compar phenotyp suscept result azithromycin ampicillin perform trimethoprim sulfamethoxazol suscept less robust assess ciprofloxacin limit isol resist detect amr gene direct stool specimen general yield low specif predict resist pair isol wherea sensit negat predict valu predict suscept often higher exampl detect ermb mpha stool yield specif sensit negat predict valu versus pair isol azithromycin resist result patient receiv azithromycin prior present univers cultur negat howev qpcr still detect shigella diarrhea associ quantiti sum molecular diagnost direct stool specimen great increas diagnost yield shigella includ set prior antibiot molecular detect drug resist gene direct stool specimen low specif confirm resist could potenti rule macrolid resist | D004405;D012760 | T007;T047 |
34,669,455 | specif sar cov antibodi detect assay n protein among pre covid sera patient protozoan helminth parasit infect aim assess specif sever acut respiratori syndrom coronavirus sar cov antibodi detect assay among peopl tissu born parasit infect test three sar cov antibodi detect assay cpass sar cov neutral antibodi detect kit cpass abbott sar cov igg assay abbott architect standard q covid igmigg combo rapid diagnost test sd rdt igmsd rdt igg among pre covid seroposit sera sever parasit infect specif assay overal howev lower specif observ among sera patient protozoan infect reticuloendotheli system human african trypanosomiasi abbott architect ci viscer leishmaniasi sd rdt igg ci patient recent malaria area seneg malaria holoendem rang abbott architect sd rdt igm cpass sd rdt igg specimen patient evid past present helminth infect overal test specif estim sera collect patient clinic suspect parasit infect test negat infect yield specif major fals posit result posit one assay specif sar cov serolog assay among sera patient tissu born parasit infect threshold requir decis individu patient care specif mark increas use confirmatori test second assay final sd rdt igg prove similar specif laboratori base assay provid option low resourc set detect anti sar cov igg indic | D000086382;D006376;D010272 | T204;T047;T067 |
34,669,454 | glucan galactomannan biomark detect invas geotrichum magnusiomyc infect retrospect evalu magnusiomyc geotrichum speci ascomycet yeast caus potenti life threaten invas fungal infect common refer geotrichosi studi aim estim incid mortal infect german tertiari care center furthermor evalu suitabl fungal biomark galactomannan gm glucan bdg recommend surrog marker magnusiomyc capitatus infect european societi clinic microbiolog infecti diseas escmid european confeder medic mycolog ecmm joint clinic guidelin diagnosi manag rare invas yeast infect detect invas geotrichosi case meet inclus criteria invas magnusiomycesgeotrichum infect retrospect identifi serum sampl cultur supernat analyz two commerci avail fungal antigen test platelia aspergillus ag eia wako glucan test control cohort outpati sampl sent lue test includ thirti eight case magnusiomycesgeotrichum infect identifi year observ period major case fungus isol intra abdomin specimen patient histori abdomin surgeryprocedur n case fungemia occur exclus haemato oncolog patient n thirti day surviv fungemia intra abdomin geotrichosi group serum sampl avail patient bloodstream nine intra abdomin infect bdg sensit none sera gm posit find support vitro experi analyz fungal cultur supernat capitatus secret signific amount bdg gm specif bdg gm magnusiomyc geotrichum infect limit haemato oncolog patient contrast current escmidecmm recommend result indic gm suitabl biomark diagnosi magnusiomyc infect contrarili bdg sensit compar candidemia | D005847;D005848;D000072742;D008351;D011509;D004718;D047071 | T116;T047;T121;T109;T123;T004 |
34,669,453 | wildlif symbiot bacteria indic health status host ecosystem lactic acid bacteria lab gut symbiont use model understand host microbiota cross talk unpredict environment condit wildlif ecosystem aim studi determin whether viabl lab inform health status wild boar popul monitor genotyp phenotyp lab base marker includ safeti phylogenet origin antibacteri activ immunomodulatori properti lab profil domin lactobacilli appear stimul protect immun respons relat strain wide use probiot result potenti healthi wildlif popul wherea microbiota overpopul enterococci observ hostil environ enterococci close relat pathogen strain develop mechan evad innat immun system pose potenti risk host health furthermor lab isol display antibacteri properti speci depend manner near abl inhibit bacteri pathogen rais possibl use la cart antibiot altern unexplor field wildlif diseas mitig studi highlight microbiolog character lab use indic wildlif health status ecolog origin deriv import wildlif symbiot microbiota import compon greater divers function bacteri popul influenc host health adapt ecosystem although mani microb part respons develop multipl physiolog process certain bacteri group lactic acid bacteria lab capac overpopul gut promot health diseas specif genet environment condit present lab exploit mani way due probiot properti particular lactobacilli howev relationship wildlif gut associ microbiota host remain elucid hand unclear whether lab enterococci associ detriment health effect could lead diseas import question proper consid field wildlif therefor clear address | D064307;D019936 | T032;T001;T007;T028 |
34,669,452 | engin lysin intrins antibacteri activ lysmk cecropin fusion enhanc antibacteri properti acinetobact baumannii bacteriophag encod lysin increas report altern combat acinetobact baumannii infect limit therapeut option avail lysin lysmk c termin amphipath helix allow penetr otherwis imperm outer membran barrier anoth approach kill gram negat pathogen lysin reli fusion peptid outer membran permeabil properti lysin work aim leverag intrins antibacteri activ lysmk fuse peptid cecropin n terminus via linker three ala gli repeat result engin lysmk elysmk engin lysin improv antibacteri activ compar parent lysin lysmk term mic kill rate kill extent elysmk fold increas activ stationari phase cell bactericid effect becom less depend intracellular osmot pressur particular colistin resist strain becom high suscept elysmk enhanc antibacteri activ observ complement deactiv human serum observ demonstr fusion lysin intrins antibacteri activ select outer membran permeabil peptid use strategi improv vitro antibacteri properti lysin import phage lysin new class enzym base antibiot increas gain interest lysin kill cell rapid degrad peptidoglycan layer result sudden osmot lysi wherea gram posit bacteria readili suscept action lysin gram negat bacteria natur resist outer membran protect peptidoglycan layer work reveal fuse outer membran permeabil peptid lysin intrins antibacteri activ result superior lysin show improv robust antibacteri activ includ worrisom colistin resist baumannii strain | D040981 | T007 |
34,669,451 | predat strategi bacterium bdellovibrio bacteriovorus result overexploit bottleneck increas antimicrobi resist altern treat infect remov resist bacteria urgent need bacteri predat bdellovibrio bacteriovorus bacteriophag therefor need better understand microbi predat prey dynam develop mass action mathemat model predat chemostat captur low substrat concentr slow growth typic intend applic area predat wastewat treatment aquacultur gut model predict predat surviv requir minim prey cell size explain bdellovibrio much smaller prey predat consid good attack rate high mortal low overexploit prey lead extinct tragedi common surpris predat take longer produc offspr outcompet predat produc fewer offspr rapid rate versus yield trade predat effici narrow region around optim paramet moreov extrem oscil wide rang condit led sever bottleneck could avoid two prey speci becam avail altern season bacteriophag outcompet bdellovibrio due higher burst size faster life cycl togeth result suggest bdellovibrio would struggl surviv singl prey explain must generalist predat suggest better suit phage environ multipl prey import discoveri antibiot led dramat drop death due infecti diseas increas level antimicrobi resist howev threaten revers progress thus need altern therapi base phage predatori bacteria kill bacteria regardless whether pathogen resist antibiot best exploit need better understand determin effect use mathemat model studi bacteri predat realist slow growth condit found generalist predat bdellovibrio effect within narrow rang condit prey exampl minimum prey cell size requir predat good would result overexploit risk extinct togeth find give insight ecolog microbi predat help explain bdellovibrio need generalist predat | D001435;D001501;D000070060 | T007;T005 |
34,669,450 | special metabolit mediat predat defens marin actinobacterium salinispora oblig marin actinobacteri genus salinispora becom model organ natur product discoveri yet littl known ecolog function compound produc taxon aim studi assess effect live cultur cultur extract two salinispora speci invertebr predat choic base feed experi use bacterivor nematod caenorhabd elegan live cultur salinispora speci less prefer escherichia coli given choic two speci c elegan prefer areniolca tropica cultur extract tropica deter c elegan arenicola suggest compound produc tropica account feed deterr bioactiv guid isol link compound lomaiviticin seri deterr activ addit assay use marin polychaet ophryotrocha siberti marin nematod support deterr activ tropica potenti predat result provid evid salinispora natur product function defens predat strategi predat defens differ close relat speci import bacteria inhabit marin sediment subject predat bacterivor eukaryot test hypothesi sediment deriv bacteria genus salinispora produc biolog activ natur product function defens predat result reveal cultur cultur extract tropica deter feed caenorhabd elegan negat affect habitat prefer marin annelid ophryotrocha siberti activ link lomaiviticin seri cytotox compound produc tropica microbi natur product function defens predat repres poor understood trait influenc communiti structur marin sediment | D039903;D008848 | T007 |
34,669,449 | function genom analys reveal open pan genom chlorovirus potenti genet innov new isol chlorovirus famili phycodnavirida larg doubl strand dna dsdna virus infect unicellular green alga present inland water virus isol use three main chlorella like green algal host cell tradit call nca sag pbi reveal extens genet divers studi perform function genom analysi chlorovirus infect three differ host phylogenet reconstruct base dna polymeras b famili gene cluster chlorovirus three distinct clade viral pan genom consist cluster ortholog group gene cog cog conserv virus total cog found exclus virus infect nca sag pbi algal host respect two third cog known function constitut dark pan genom chlorovirus studi focus gene may identifi import novelti proport function character cog compos pan genom core genom similar relat transcript rna process protein metabol virion morphogenesi least fold repres core genom bipartit network construct evidenc cog share among host specif virus identifi cog share least one virus differ host group final result reveal open pan genom chlorovirus well establish core genom indic isol new chlorovirus valuabl sourc genet discoveri import chlorovirus larg dsdna virus infect unicellular green alga distribut worldwid freshwat environ compris genet divers group virus howev comprehens investig genom evolut virus still miss perform function pan genom analysi compris chlorovirus associ three differ algal host famili chlorellacea refer zoochlorella endosymbiot lifestyl identifi set high conserv gene relat essenti function viral replic cycl sever gene uniqu distinct isol result open pan genom chlorovirus profil associ generalist organ new insight evolut ecolog chlorovirus present ultim result highlight potenti genet divers new isol | D016679 | T028 |
34,669,448 | cytochrom omc essenti extracellular electron transport via conduct pili geobact sulfurreducen strain kn multi heme c type cytochrom omc one central compon use extracellular electron transport geobact sulfurreducen strain dl role microb includ strain g sulfurreducen current matter debat therefor investig function omc g sulfurreducen strain kn even effect extracellular electron transfer dl strain found delet omc strain kn negat impact rate fe iii oxid reduct cell express conduct filament replac wild type pilin gene aro pilin gene elimin omc defici strain abil transport electron insolubl electron acceptor diminish filament conduct result consist concept electr conduct pili primari conduit long rang electron transfer g sulfurreducen close relat speci find coupl lack omc homolog microb capabl extracellular electron transfer suggest omc common critic compon extracellular electron transfer import omc wide studi note one key compon extracellular electron exchang geobact sulfurreducen strain dl howev true import omc warrant investig well known bacteria even within geobacteracea famili contain omc homolog mani bacteria capabl extracellular electron transfer lack abund type outer surfac c type cytochrom addit debat import omc filament mechan extracellular electron transport insolubl electron acceptor g sulfurreducen suggest filament compris omc rather e pili predomin conduct filament express g sulfurreducen howev result present along multipl sourc evid indic omc filament primari conduct protein nanowir express g sulfurreducen | D004583;D045302 | T007;T196;T081 |
34,669,447 | competit exclus phytopathogen serratia marcescen squash bug vector gut endosymbiont caballeronia mani insect harbor microbi symbiot partner offer protect pathogen parasitoid natur enemi mount evid suggest symbiot microb play key role determin infect outcom insect vector make import player quest develop novel vector control strategi use squash bug anasa tristi investig presenc caballeronia symbiont affect persist intens phytopathogen serratia marcescen within insect vector rear insect aposymbiot differ caballeronia isol infect marcescen sampl insect period assess intens persist pathogen infect squash bug harbor caballeronia consist much lower intens infect clear marcescen signific faster aposymbiot counterpart pattern held even revers time exposur symbiont pathogen taken togeth result indic caballeronia symbiont play essenti role marcescen infect outcom squash bug could use alter vector compet enhanc agricultur product futur import insect microb symbios repeat shown profound impact insect abil vector pathogen host use symbiot microb control insect vector popul grow interest agricultur set studi examin symbiot microb affect dynam plant pathogen infect within squash bug vector anasa tristi well document pest squash cucurbit plant vector serratia marcescen causat agent cucurbit yellow vine diseas provid evid symbiont caballeronia prevent success long term establish marcescen squash bug find give us insight symbiont pathogen dynam within squash bug could ultim determin abil transmit pathogen leverag interrupt diseas transmiss system | D042521;D020062 | T204;T007 |
34,669,446 | streptomyc coelicolor vesicl mani molecul deliv streptomyc coelicolor model organ studi streptomyc genus gram posit bacteria undergo complex life cycl produc broad repertoir bioactiv metabolit extracellular enzym studi investig product character membran vesicl mvs liquid cultur coelicolor structur biochem point view achiev combin microscop physic omic analys two main popul mvs differ size cargo isol purifi coelicolor mv cargo determin complex contain differ kind protein metabolit particular total protein involv cell metabolismdifferenti molecular processingtransport stress respons identifi mvs latter function class also import bacteri morpho physiolog differenti subset protein protect degrad follow treatment mvs proteinas k indic local insid vesicl moreov coelicolor mvs contain array metabolit antibiot vitamin amino acid compon carbon metabol conclus analysi provid detail inform coelicolor mvs basal condit correspond content may use near futur elucid vesicl biogenesi function import streptomycet wide distribut natur character complex life cycl involv morpholog differenti relev industri produc half clinic use antibiot well import pharmaceut product natur origin streptomyc coelicolor model organ studi bacteri differenti bioactiv molecul product coelicolor produc extracellular vesicl carri mani molecul protein metabolit includ antibiot elucid coelicolor extracellular vesicl cargo help us understand differ aspect streptomycet physiolog cell communic differenti respons environment stimuli moreov capabl vesicl carri differ kind biomolecul open new biotechnolog possibl relat drug deliveri inde decod molecular mechan involv cargo select may lead custom extracellular vesicl content | D013302;D048372 | T007 |
34,669,445 | investig crosstalk grpperkatf signal pathway renal apoptosi induc nephropathogen infecti bronchiti virus infect studi aim explor crosstalk grpperkatf signal pathway renal apoptosi induc nephropathogen infecti bronchiti virus nibv hy line brown chicken divid two group con n dis n day age chicken dis group intranas inject sx strain ml venous blood kidney tissu collect day postinfect result show nibv infect upregul level creatinin uric acid calcium ca level histopatholog examin reveal sever hemorrhag inflammatori cell infiltr near renal tubul meanwhil nibv virus particl apoptot bodi observ ultramicro electron microscop addit rt qpcr western blot show nibv upregul express grp perk eif atf chop caspas caspas p bax contrari downregul express bcl furthermor immunofluoresc local analysi show posit express bcl protein signific decreas correl analysi indic endoplasm reticulum er stress gene express apoptosi gene express renal injuri potenti relat taken togeth nibv infect induc renal er stress apoptosi activ grpperkatf signal pathway lead kidney damag import nephropathogen infecti bronchiti virus nibv induc renal endoplasm reticulum stress chicken nibv infect induc kidney apoptosi chicken grpperkatf signal pathway potenti relat renal apoptosi induc nibv | D017209 | T043;T116;T123 |
34,669,444 | develop ict first class anti btna antibodi activ vv cell mediat antitumor immun respons gamma delta cell among potent cytotox lymphocyt activ antibutyrophilin btna antibodi prime divers tumor cell type kill vv cell predomin cell subset peripher circul mechan independ tumor antigenmajor histocompat complex mhc complex report describ develop human monoclon antibodi ict subnanomolar affin three isoform btna demonstr ict activ vv cell kill multipl tumor cell line primari tumor cell normal healthi cell effici process requir approxim target occup show ict activ depend btna btna independ phosphoantigen pag bind b domain ict delay growth hematolog solid tumor xenograft prolong surviv nodscidilr null nsg mice adopt transfer human vv cell singl multipl dose safeti studi cynomolgus macaqu receiv mgkg week ict well toler respect pharmacodynam endpoint ict select activ vv cell without affect btna express lymphocyt b cell first human phase open label clinic studi ict thus initi patient advanc stage solid tumor evict nct eudract preliminari result show ict well toler pharmacodynam activ first patient digit patholog analysi tumor biopsi patient melanoma suggest ict may promot immun cell infiltr within tumor microenviron | D008213;D013601 | T043;T025 |
34,669,443 | macrophag migrat inhibitori factor drive patholog mous model spondyloarthr associ human diseas spondyloarthr spa type immun mediat inflammatori arthriti system rheumat diseas primarili affect joint spine gut skin eye macrophag migrat inhibitori factor mif proinflammatori cytokin yet mif patholog role spa unknown observ express mif receptor cd increas blood tissu curdlan glucan treat skg mice mous model spa found neutrophil substanti expand produc mif curdlan treat skg mice human neutrophil spa patient secret higher concentr mif compar healthi individu although genet delet mif mif substanti suppress sever spa featur adopt transfer inflammatori neutrophil induc spa patholog curdlan treat mif skg mice contrast block function neutrophil antigr antibodi suppress curdlan induc spa like phenotyp also determin system mif overexpress suffici induc spa like clinic featur skg mice enhanc type immun wherea skg mice treat mif antagonist prevent attenu curdlan induc spa manifest mechanist identifi mif intensifi type immun boost human mous regulatori cell reg acquisit h celllik phenotyp includ regul interleukin il il vitro reg blood synovi fluid spa patient patholog h phenotyp result indic mif crucial regul potenti therapeut target type immun mediat arthriti | D008263;D025241 | T129;T047;T116;T123 |
34,669,442 | fatal enhanc respiratori syncyti virus diseas toddler two toddler immun formalin inactiv vaccin respiratori syncyti virus firsv unit state die enhanc rsv diseas erd sever form ill result aberr prime antivir immun respons vaccin immun children subsequ expos wild type virus hospit event hamper rsv vaccin develop decad provid character clinic immunopatholog transcript signatur fatal human erd outlin evid safeti evalu rsv vaccin framework understand diseas enhanc pathogen general | D003141;D018357;D022261 | T129;T047;T121 |
34,669,441 | rapid assay provid site quantif tetrahydrocannabinol oral fluid tetrahydrocannabinol thc primari psychoact ingredi cannabi impair cognit motor function concentr depend fashion drug test common perform employ law enforc purpos howev avail test produc low sensit binari result later flow assay long turnaround gas chromatographymass spectrometri enabl site thc quantif minut develop rapid assay oral thc analysi call epoch express probe site cannabi inhal epoch featur distinct sensor design radial membran transmiss optic contain compact cartridg integr approach permit assay complet within min detect limit ngml thc regulatori guidelin ngml proof concept field test appli epoch assess oral fluid sampl cannabi user n control n epoch detect oral thc specimen cannabi smoker median concentr ngml thc infus food consum longitudin monitor show fast drop thc concentr within first hour cannabi smoke half life hour | D013759;D015813 | T121;T109;T059 |
34,669,440 | peptid base urinari monitor fibrot nonalcohol steatohepat mass barcod activ base sensor noninvas detect nonalcohol steatohepat nash progress form nonalcohol fatti liver diseas promis improv patient screen acceler drug trial reduc health care cost basi proteas dysregul biolog pathway fibrot nash develop glymps bio test system gbts multiplex quantif liver proteas activ gbts nash compris mixtur mass barcod pegyl peptid administ intraven sens liver proteas activ releas mass barcod report urin analysi mass spectrometri identifi proteas signatur nash transcriptom analysi human liver biopsi identifi proteas panel discrimin clinic relev nash f fibrosi f f high classif accuraci across two independ patient dataset screen candid substrat identifi panel peptid exhibit high activ proteas panel cholin defici l amino acid defin high fat diet cdahfd mous model binari classifi train urin sampl discrimin fibrot nash simpl steatosi healthi control across rang nondiseas condit indic diseas regress upon diet chang area receiv oper characterist auroc use hepatoprotect tripl combin treatment fxr agonist acc ask inhibitor rat model nash urinari classif distinguish f f f anim indic therapeut respons earli week treatment auroc result support gbts nash diagnos fibrot nash via infus peptid monitor chang diseas sever indic earli treatment respons | D065626 | T047 |
34,669,439 | dna bind tlr express red blood cell promot innat immun activ anemia red blood cell rbcs essenti aerob respir deliveri oxygen distant tissu howev rbcs current consid immunolog inert secondari function rbcs identifi show rbcs serv critic immun sensor surfac express nucleic acidsens toll like receptor tlr mammalian rbcs express tlr surfac bound cpg contain dna deriv bacteria plasmodia mitochondria rbc bound mitochondri dna increas human murin sepsi pneumonia vivo cpg carri rbcs drove acceler erythrophagocytosi innat immun activ character increas interferon signal erythroid specif delet tlr abrog erythrophagocytosi decreas local system cytokin product cpg induc inflamm polymicrobi sepsi thus detect captur nucleic acid tlr express rbcs regul red cell clearanc inflammatori cytokin product demonstr rbcs function immun sentinel patholog state consist find rbc bound mitochondri dna elev individu viral pneumonia sepsi secondari coronavirus diseas covid associ anemia sever diseas find uncov previous unappreci role rbcs critic player inflamm distinct function gas transport | D000740;D007113;D051217 | T116;T047;T129;T032;T192 |
34,669,438 | isol character lignocellulos degrad geobacillus thermoleovoran yellowston nation park microbi degrad lignocellulos natur ecosystem present numer biotechnolog opportun includ biofuel product agricultur wast feedstock biomass explor degrad potenti specif thermophil identifi character extremophil microorgan isol hot spring environ capabl biodegrad lignin cellulos substrat thermoalkalin condit use combin cultur genom metabolom techniqu organ use lignin cellulos sole carbon sourc c isol sediment slurri thermoalkalin hot spring c ph yellowston nation park full length rrna gene sequenc indic isol close relat geobacillus thermoleovoran interest isol demonstr biofilm format lignin phenotyp correl increas bioconvers assess metabolit level chang two geobacillus isol two repres spring undertaken character metabol respons associ growth glucos versus lignin carbon sourc function ph temperatur overal result studi support thermoalkalin spring harbor g thermoleovoran microorgan lignocellulos biomass degrad capabl potenti downstream biotechnolog applic import sinc lignocellulos biomass repres major agro industri wast renew resourc potenti replac nonrenew petroleum base product energi product consider microbi ligninolyt cellulolyt enzym high interest biorefineri valor lignocellulos biomass withstand extrem condit eg high temperatur high ph requir process great interest ligninolyt potenti specif geobacillus thermoleovoran isol function broad rang ph temperatur sinc lignin bottleneck bioprocess lignocellulos studi result obtain g thermoleovoran isol origin ynp spring signific microorgan alkalin thermal environ discov lignin cellulos biodegrad capabl work open new avenu biotechnolog valor lignocellulos biomass industri scale | D056506;D008031 | T007;T109;T123 |
34,669,437 | two tonb depend transport methylosinus trichosporium obb respons uptak differ form methanobactin involv canon copper switch copper import compon methanotroph physiolog control express activ altern form methan monooxygenas mmo collect copper methanotroph secret chalkophor copper bind compound call methanobactin mb mb ribosom synthes posttransl modifi polypeptid ripp bind copper collect mbnt tonb depend transport tbdt structur differ form mb character show differ form mb collect specif tbdts report model methanotroph methylosinus trichosporium obb express tbdt requir uptak differ mb made methylocysti sp strain sb mb sb induc presenc mb sb suggest methanotroph develop specif machineri regulatori system activ take mb methanotroph copper collect moreov canon copper switch trichosporium obb control express altern mmos appar one two tbdts requir mb obb mb sb uptak knock disrupt tbdts knock data indic mb uptak includ uptak exogen mb play import role copper switch trichosporium obb thus overal activ base data propos revis model copper switch methanotroph involv mb uptak import studi demonstr differ tbdts model methanotroph methylosinus trichosporium obb respons uptak either endogen mb exogen mb interest presenc exogen mb induc express specif tbdt trichosporium obb suggest methanotroph abl activ take mb produc other work contribut understand microb collect compet copper also help inform uptak coordin express differ form methan monooxygenas studi like import develop better understand methanotroph interact via synthesi secret secondari metabolit methanobactin thus provid addit mean wherebi microb manipul varieti environment industri purpos | D020602 | T007 |
34,669,436 | util effici human milk oligosaccharid human associ akkermansia strain depend akkermansia muciniphila mucin degrad bacterium found human gut often associ posit human health howev despit detect earli month age littl known role akkermansia infant gut human milk oligosaccharid hmos abund compon human milk structur similar oligosaccharid compris mucin prefer growth substrat human associ akkermansia limit subset intestin bacteria shown grow well hmos mucin therefor examin abil genom divers strain akkermansia grow hmos first screen genom repres four known akkermansia phylogroup examin metabol potenti degrad hmos furthermor examin abil repres isol grow individu hmos mucin background analyz result metabolit akkermansia genom equip array glycosid hydrolas associ hmo deconstruct repres strain abl grow hmos various effici growth yield strain csun belong amiv phylogroup grew highest level presenc fucosyl sialyl hmos activ may partial relat increas copi number andor enzym activ fucosidas sialidas galactosidas studi examin util individu purifi hmos akkermansia strain repres known phylogroup studi requir examin hmo ingest influenc gut microbi ecolog infant harbor differ akkermansia phylogroup import human milk oligosaccharid hmos third abund compon breast milk provid sever benefit develop infant includ recruit benefici bacteria human gut akkermansia strain larg consid benefici bacteria detect colostrum breast milk young infant muciniphila muc belong ami phylogroup contribut hmo deconstruct capac infant use phylogenom examin genom capac four akkermansia phylogroup deconstruct hmos inde phylogroup contain differ genom capac deconstruct hmos repres strain phylogroup abl grow use hmos akkermansia hmo interact potenti influenc gut microbi ecolog earli life critic time develop gut microbiom infant health | D000069196;D008895 | T007;T031;T001 |
34,669,435 | arbuscular mycorrhiz tree communiti greater soil fungal divers relat abund saprotroph pathogen ectomycorrhiz tree communiti tree associ differ mycorrhiza often differ effect litter decomposit nutrient cycl soil organ matter som dynam plant soil interact exampl due differ arbuscular mycorrhiz ectomycorrhiz ecm tree leaf root trait ecm associ soil lower rate c n cycl lower n avail associ soil observ suggest mani group nonmycorrhiz fungi affect mycorrhiz associ domin tree control nutrient avail test overarch hypothesi explor influenc predomin forest mycorrhiz type miner n avail soil fungal communiti use next generat amplicon sequenc soil four temper hardwood forest southern indiana unit state studi three forest form natur gradient mycorrhiz domin tree basal area ecm basal area fourth forest contain factori experi test long term n addit domin mycorrhiz type found overal fungal divers well divers relat abund plant pathogen saprotroph fungi increas greater tree domin addit tree communiti mycorrhiz associ explain variat fungal communiti composit abiot variabl includ soil depth som content nitrif rate miner n avail find suggest tree mycorrhiz associ may good predictor divers composit function potenti soil fungal communiti temper hardwood forest observ help explain differ biogeochemistri communiti dynam found forest stand domin differ mycorrhiz type import work explor differ mycorrhiz associ temper hardwood tree ie arbuscular versus ectomycorrhiz ecm associ affect soil fungal communiti alter divers relat abund saprotroph plant pathogen fungi along natur gradient mycorrhiz domin temper hardwood forest predict becom domin climat chang studi examin soil communiti along mycorrhiz gradient necessari understand global chang may alter futur soil fungal communiti function potenti along recent studi identifi possibl global trend frequenc specif fungal function group respons nutrient cycl plant soil interact relat mycorrhiz associ | D038821 | T004 |
34,669,434 | spt structur subunit saga complex regul aspergillus fumigatus biofilm format asexu develop virul exopolysaccharid galactosaminogalactan gag play import role mediat adhes biofilm format virul pathogen fungus aspergillus fumigatus previous work show fumigatus lim domain bind protein ptab form complex sequenc specif transcript factor soma regul gag biosynthesi biofilm format asexu develop howev transcript coactiv requir biofilm format fumigatus remain uncharacter studi spt orthologu subunit saccharomyc cerevisia transcript coactiv spt ada gcn acetyltransferas saga complex identifi regul biofilm format asexu develop fumigatus loss spt caus sever defect gag biosynthesi biofilm format conidi virul fumigatus rna sequenc data demonstr spt posit regul express gag biosynthesi gene uge agd development regul meda gene involv conidi pathway moreov subunit saga complex known yeast could immunoprecipit spt suggest spt act structur subunit saga complex furthermor distinct modul saga regul gag biosynthesi biofilm format asexu develop fumigatus various degre summari novel biofilm regul spt report play crucial role regul fungal asexu develop gag biosynthesi virul fumigatus find expand knowledg regulatori circuit saga complex relev biofilm format asexu develop fumigatus import eukaryot transcript regul larg number protein rang sequenc specif dna bind factor transcript coactiv chromatin regul general transcript machineri regul previous research indic sequenc specif complex somaptab regul biofilm format asexu develop aspergillus fumigatus howev transcript coactiv work sequenc specif transcript factor regul fumigatus biofilm format remain uncharacter studi spt orthologu subunit saccharomyc cerevisia spt ada gcn acetyltransferas saga complex identifi novel regul biofilm format asexu develop fumigatus loss spt caus sever defect galactosaminogalactan gag product conidi virul moreov near modul saga complex requir biofilm format asexu develop fumigatus result establish saga complex transcript coactiv requir biofilm format asexu develop fumigatus | D001232;D018441;D005656 | T004;T007;T116;T123 |
34,669,433 | progress manag pancreat neuroendocrin tumor pancreat neuroendocrin tumor pnet heterogen orphan group neoplasm vari histolog clinic featur prognosi manag treatment pnet high depend stage present tumor grade differenti presenc symptom hormon overproduct local growth tumor burden rate progress us food drug administr recent approv mani novel treatment alter decis make posit impact care prognosi patient review focus signific progress made manag pnet past decad well activ area research | D018358;D010190 | T191 |
34,669,432 | mrna vaccin covid pandem beyond sever acut respiratori syndrom coronavirus sar cov caus coronavirus diseas covid emerg china decemb quick spread around globe kill million peopl caus sever econom crisi extraordinari situat prompt entiti govern industri academia work togeth unpreced speed develop safe effect vaccin inde vaccin multipl type generat record time mani evalu clinic trial messeng rna mrna vaccin emerg lead candid due speed develop high degre safeti efficaci date two mrna vaccin receiv approv human use provid proof feasibl next generat vaccin modal review give detail overview type mrna vaccin develop sar cov discuss compar preclin clinic data give mechanist overview immun respons generat mrna vaccin specul challeng promis futur emerg vaccin platform | D000086382 | T047;T067 |
34,669,431 | gut brain axi preclin evid firm establish bidirect interact among brain gut gut microbiom candid signal molecul least three communic channel identifi communic within system nonlinear bidirect multipl feedback loop like involv interact differ channel alter gut brain microbiom interact identifi rodent model sever digest psychiatr neurolog disord alter gut brain interact clear establish irrit bowel syndrom causat role microbiom irrit bowel syndrom remain determin absenc specif microbi target effect therapi current approach limit dietari intervent central target pharmacolog behavior approach comprehens understand causat influenc within gut brain microbiom system well design random control trial need translat excit preclin find effect therapi | D000069196;D043183;D064307 | T007;T047;T001;T032;T028 |
34,669,430 | clinic perspect igg relat diseas classif immunoglobulin g relat diseas igg rd system immun mediat fibroinflammatori diseas sinc discoveri near two decad ago understand pathophysiolog clinic manifest grown substanti earli diagnosi treatment elus diseas prevent substanti organ damag end stage fibrosi emphas need prompt recognit accur character igg rd classif criteria endors american colleg rheumatolog european allianc associ rheumatolog provid framework establish diagnosi clinic set process involv recogn typic manifest diseas incorpor clinic radiolog serolog histopatholog inform well exclud diseas mimick glucocorticoid rituximab effect induc remiss igg rd patient optim approach long term manag igg rd remain area activ clinic research | D000077733 | T047 |
34,669,429 | colibrimycin novel halogen hybrid polyketid synthas nonribosom peptid synthetas pks nrps compound produc streptomyc sp strain cs improv genom sequenc techniqu brought light biosynthet potenti actinomycet due larg number gene cluster present compar number known compound genom mine recent strategi search novel bioactiv compound involv analysi sequenc genom identifi uncharacter natur product biosynthet gene cluster mani cryptic silent laboratori condit develop experiment approach identifi product owe import halogen term structur divers bioavail bioactiv search new halogen bioactiv compound becom interest issu field natur product discoveri follow purpos screen halogenas code gene perform streptomyc strain isol fungus grow ant attini tribe use bioinformat tool antismash blast six halogenas code gene identifi gene locat within biosynthet gene cluster bgcs studi construct sever mutant identif putat halogen compound produc comparison metabolit product profil wild type strain correspond mutant ultrahigh perform liquid chromatographi uv high perform liquid chromatographi mass spectrometri allow us identif novel famili halogen compound streptomyc sp strain cs design colibrimycin import genom mine proven use search novel bioactiv compound produc microorgan halogenas compris interest start point work identifi new halogenas code gene led discoveri novel lipopetid nonribosom peptid synthetasepolyketid synthas nrpspks deriv natur product colibrimycin produc streptomyc sp strain cs isol attini ant nich colibrimycin display unusu ketoamid moieti peptid structur although biosynthet origin remain unknown presenc might relat hypothet inhibit virus proteas togeth presenc halogenas repres featur incorpor arsenal structur modif avail combinatori biosynthesi | D048630;D013302 | T116;T007;T126 |
34,669,428 | sialic acid bind site vp bluetongu virus use virus entri bluetongu virus btv member orbivirus genus transmit bite midg gnat culicoid sp one widespread anim pathogen caus serious outbreak domest anim particular sheep high econom impact non envelop btv particl doubl capsid structur seven protein genom doubl strand rna segment although outermost spike like vp act attach protein btv entri specif host receptor identifi btv recent high resolut cryo electron cryoem structur biolog data suggest vp may interact sialic acid sas confirm generat protein base nanoparticl display multival vp use probe glycan array data show vp bind link sa high affin also bind link sa maackia amurensi lectin ii mal ii sambucus nigra lectin sna specif bind link link sas respect inhibit btv infect virus growth suscept sheep cell sna alon inhibit virus growth culicoid deriv cell combin hydrogen deuterium exchang mass spectrometri site direct mutagenesi allow identif specif sa bind residu vp studi provid direct evid sialic acid act key receptor btv outer capsid protein vp specif bind sa btv entri mammalian insect cell import date receptor assign non envelop bluetongu virus determin outermost spike like vp protein respons host cell attach via interact sialic acid first generat protein base vp nanoparticl multival present recombin vp protein use nanoparticl display vp probe glycan array identifi vp bind link link sialic acid lectin inhibitor target linkag sialic acid show strong inhibit btv infect progeni virus product mammalian cell howev inhibit seen lectin target link sialic acid insect vector cell addit identifi vp sialic acid bind site expos tip domain data provid direct evid sialic acid act key receptor btv attach entri mammalian insect cell | D001665;D053586 | T040;T192;T038 |
34,669,427 | specialist aphid feed caus local activ salicyl jasmon acid signal arabidopsi vein aphid phloem sap feeder probe leaf tissu activ complex network plant defens respons phytohormon signal play major role network howev dynam signal spread yet clarifi despit grow knowledg transcriptom chang upon infest result often differ due sampl vari strong tissu collect singl feed site individu leav pool infest leav whole plant rosett studi focus activ salicyl acid sa jasmon acid ja signal arabidopsi leav infest cabbag aphid brevicoryn brassica high spatio tempor resolut use genet encod fluoresc biosensor histochemistri quantit revers transcript pcr precis map activ distinct branch phytohormon signal found rapid induct sa ja signal marker cell surround stylet punctur coloc callos deposit pr jaz detect activ h postinfest hpi increas spread along vein hpi lesser extent within epiderm pavement cell sa signal wave appear parallel ja associ signal continu increas time result first show local activ sa ja relat respons stylet penetr arabidopsi leav bring detail insight spatio tempor complex plant defens activ specialist aphid attack formula see text copyright author open access articl distribut cc nc nd intern licens | D001042;D017360;D029681 | T204;T116;T002 |
34,669,426 | glycan hole area hiv envelop trimer contribut promin induct autolog neutral human immunodefici virus type hiv trimer envelop glycoprotein env heavili glycosyl creat dens glycan shield protect under peptid surfac antibodi recognit absenc conserv glycan due miss potenti n link glycosyl site pngs result strain specif autolog neutral antibodi nab respons sought gain deeper understand autolog neutral introduc hole otherwis dens glycan shield amc amc sosip trimer specif knock n n glycan absent well character b sosip trimer observ stronger autolog nab respons also analyz high variabl nab respons induc rabbit divers sosip trimer subtyp b c statist analysi use linear regress reveal cumul area expos trimer glycan hole correl magnitud autolog nab respons import forti year first descript hiv search protect vaccin still ongo sole target antibodi neutral virus trimer envelop glycoprotein env locat viral surfac glycoprotein surfac cover glycan shield under protein compon recognit immun system howev env trimer viral strain hole glycan shield immun anim develop antibodi glycan hole antibodi general strain specif sought gain deeper understand drive specif immun respons first show strain specif neutral antibodi respons increas creat artifici hole glycan shield second studi divers set env trimer differ characterist found surfac area glycan hole contribut promin induct strain specif neutral antibodi | D055503 | T067 |
34,669,425 | coprinopsi cinerea use laccas lcc defens strategi elimin oxid stress fungal fungal interact frequent laccas trigger fungal cocultiv overexpress function activ laccas cocultur clarifi previous report gongronella sp w w mucoromycota mucoromycet specif trigger laccas lcc overexpress coprinopsi cinerea basidiomycota agaricomycet systemat analyz function overexpress laccas fungal interact c cinerea mycelia initi lcc overexpress chosen transcriptom analysi result show accompani specif util fructos carbohydr substrat oxid stress deriv antagonist compound secret w appear signal critic laccas product c cinerea decreas reactiv oxygen speci ros c cinerea wild type strain follow increas laccas product lcc transcript laccas activ stop comparison increas h content myceli ros level observ entir cocultiv lcc silenc c cinerea strain moreov lcc silenc slow c cinerea myceli growth affect hyphal morpholog decreas asexu sporul cocultur result show intracellular ros act signal molecul stimul defens respons c cinerea express oxid stress respons regul skn various detoxif protein lcc take part defens strategi elimin oxid stress interspecif interact w import overproduct laccas interspecif fungal interact well known howev exact role upregul laccas remain underexplor base compar transcriptom analysi c cinerea gene silenc laccas lcc show oxid stress deriv antagonist compound secret gongronella sp w signal critic laccas lcc product coprinopsi cinerea intracellular ros act signal molecul stimul defens respons c cinerea express oxid stress respons regul skn various detoxif protein ultim lcc take part defens strategi elimin oxid stress help cell growth develop interspecif interact gongronella sp w find deepen understand fungal interact natur popul communiti | D000363;D042845 | T004;T116;T126 |
34,669,424 | brussowvirus sw requir cell surfac associ polysaccharid recogn streptococcus thermophilus host four b acteriophag nsensit utant bim dairi starter bacterium streptococcus thermophilus uccst isol follow challeng brussowvirus sw bim display alter sediment phenotyp whole genom sequenc compar genom analysi bim uncov mutat within famili glycosyltransferas encod gene orf uccst locat within variabl region cell wall associ r hamnos g lucos p olym rgp biosynthesi locus design rgp gene cluster complement repres bim thermophilus b nativ orf uccst restor phage sensit compar parent strain detail bioinformat analysi gene product orf uccst identifi function homolog lactococcus lacti p oli accharid p ellicl psp initi wpsa biochem analysi cell wall fraction strain uccst b determin mutat within orf uccst result loss side chain decor rgp backbon structur furthermor demonstr intact rgp structur incorpor side chain structur essenti phage bind fluoresc label studi overal studi confirm rgp gene cluster thermophilus encod biosynthet machineri cell surfac associ polysaccharid essenti bind subsequ infect brussowvirus thus enhanc understand thermophilus phage host dynam import streptococcus thermophilus import starter cultur bacterium global dairi ferment process use product various chees yogurt bacteriophag predat speci result substandard product qualiti rare case complet ferment collaps mitig risk necessari understand phage host interact process commenc recognit adsorpt specif host encod cell surfac receptor bacteriophag new group thermophilus phage discov import underpin genom element specifi surfac receptor appar research identifi singl gene critic biosynthesi saccharid moieti requir phage adsorpt thermophilus host acquir knowledg provid novel insight phage host interact econom import starter speci | D001435;D017906;D017108 | T005 |
34,669,423 | genom mosaic field strain mycoplasma bovi footprint host horizont chromosom transfer horizont gene transfer long thought margin mollicut capac wall less bacteria exchang larg chromosom region recent document mycoplasma chromosom transfer mct unconvent mechan reli presenc function integr conjug element ice least one partner involv horizont acquisit small larg chromosom fragment part donor genom result progeni compos infinit varieti mosaic genom present studi focus mycoplasma bovi import pathogen cattl respons major econom loss worldwid combin phylogenet tree reconstruct detail compar genom analys isol collect spain confirm mosaic natur field isol map chromosom transfer exchang hypothet ancestor studi provid evid mct take place field like coinfect multipl strain mobil genet element mges classic contributor genom plastic presenc phage insert sequenc iss ice also investig data reveal element widespread within bovi speci evidenc classic horizont transfer phage ice addit mct event contribut wide genom divers reorgan within speci may tremend impact diagnost diseas control import mycoplasma bovi major pathogen cattl signific detriment effect econom anim welfar cattl rear worldwid understand evolut adapt potenti pathogen mycoplasma speci natur host essenti combat studi document occurr mycoplasma chromosom transfer atyp mechan horizont gene transfer field isol bovi provid new insight evolut pathogen speci natur host although event expect occur low frequenc impact account genom wide varieti reorgan within bovi speci may compromis diagnost diseas control | D045682;D008973 | T007 |
34,669,421 | orthogon design experi optim lipid nanoparticl mrna engin car cell viral engin chimer antigen receptor car cell therapi potent target cancer immunotherapi perman car express lead sever advers effect nonvir messeng rna mrna car cell explor overcom drawback electropor common cell transfect method limit cytotox potenti safer nonvir deliveri strategi sequenti librari ioniz lipid nanoparticl lnp formul vari excipi composit screen comparison standard formul improv mrna deliveri cell low cytotox reveal b top formul fold increas mrna deliveri compar electropor primari human cell b lnps induc compar car express reduc cytotox demonstr potent cancer cell kill result demonstr impact excipi optim lnp perform support b lnps potent mrna deliveri platform cell engin | D053758 | T073 |
34,669,418 | pseudonatur product occur frequent biolog relev compound new methodolog classifi fragment combin character pseudonatur product pnps describ sourc code base open sourc tool organ python packag task execut individu within context scalabl robust workflow first structur standard duplic entri filter molecul probe presenc predefin fragment molecul one match fragment combin classifi algorithm consid pairwis relat posit fragment within molecul fuse atom linker intermediari ring result differ possibl fragment combin categori final combin given molecul assembl fragment combin graph fragment node combin type edg workflow appli character pnps chembl databas via comparison fragment combin graph natur product np refer repres dictionari natur product murcko fragment extract structur previous describ use defin np fragment result indic ca biolog relev compound list chembl compli pnp definit therefor pnps occur frequent among known biolog relev small molecul major pnps contain two four fragment main distribut five differ combin type find may provid guidanc design new pnps | D001688;D054852 | T170;T121;T123 |
34,669,417 | chromosom region mainten xpocrm anticanc target discoveri inhibitor chromosom region mainten crm major nuclear export receptor protein contribut cell homeostasi mediat transport cargo nucleus cytoplasm crm therapeut target compris sever tumor type includ osteosarcoma multipl myeloma glioma pancreat cancer past decad dozen crm inhibitor discov develop includ kpt receiv fda approv multipl myeloma mm diffus larg b cell lymphoma dlbcl respect review summar biolog function crm current understand role crm play cancer discoveri crm small molecul inhibitor preclin clinic studi kpt recent develop inhibitor new crm inhibit mechan structur dynam discuss review hope guid futur design optim crm inhibitor | D055808 | T062 |
34,669,416 | dft base stereochem rational bifunct brnsted acidbas catalyz diastereodiverg enantioselect aza henri reaction nitro ester pair chiral bis amidin bam proton complex provid reagent catalyst control high diastereo enantioselect direct aza henri reaction lead alkyl substitut diamino ester c symmetr ligand provid high anti select nonsymmetr congen exhibit syn select exampl diastereodiverg enantioselect catalysi detail comput analysi report first time one support distinct model select result hinder bind caviti c symmetr ligand bind congest pocket accommod four hydrogen bond contact among ligand substrat ultim favor pre syn arrang highlight pyridinium azomethin activ quinolinium nitron activ complementari transit state reveal wide rang altern compar c c symmetr catalyst highlight distinct electrophil bind orient despit common hydrogen bond donor acceptor featur among factor drive unusu high syn diastereoselect favor dispers forc leverag anthracenyl substitu c symmetr ligand | D000143;D004952 | T103;T109 |
34,669,415 | role pigment protein coupl energi transport dynam fenna matthew olson complex role pigment protein coupl dynam photosynthet energi transport chromophor complex fulli understood excit energi transfer photosynthet system tremend effici particular investig excit energi transport fenna matthew olson fmo complex exciton dynam excit energi transfer eet depend interact excit chromophor environ theoret model believ bacteriochlorophyl bchla site surround local protein environ contradict structur analysi fmo complex base differ valu pigment protein coupl differ site measur adiabat limit theoret investig effect heterogen local protein environ eet process realist site depend model system bath coupl result show interact may critic valu coher energi transfer process furthermor verifi two transport pathway coher stabl import paramet reorgan energi environment interact quantum dynam simul show correl fluctuat keep oscil coher excit long timescal addit due inhomogen pigment protein coupl differ bchl site asymmetr excit oscil timescal | D025541;D045342 | T116;T109;T123 |
34,669,412 | longitudin larg scale semiquantit proteom data stabil across multipl instrument platform rapid develop mass spectrometri ms base proteom method label free semiquantit proteom becom increas popular tool profil global protein abund unbias manner howev reproduc data across time lc ms platform well character evalu perform three lc ms platform orbitrap elit q exact hf orbitrap fusion label free semiquantit analysi cell surfac protein six year period sucros gradient ultracentrifug use surfaceom enrich follow gel separ depth protein identif establish workflow consist detect reproduc quantifi putat cell surfac protein human acut myeloid leukemia aml cell line three platform knowledg first studi report high reproduc semiquantit proteom data collect biolog replic across multipl year lc ms platform data provid experiment justif semiquantit proteom studi design execut multiyear time interv differ platform multiyear multiplatform experiment design like enabl larger scale proteom studi facilit longitudin proteom studi investig lack access high throughput ms facil data avail via proteomexchang identifi pxd | D020543;D040901 | T091;T116;T123 |
34,669,409 | cell base drug discoveri identif optim small molecul reduc c myc protein level cell elev express c myc oncogen one common abnorm human cancer unfortun effort identifi pharmacolog inhibitor direct target myc yet yield drug like molecul due lack known small molecul bind pocket protein could exploit disrupt myc function recent describ strategi target myc indirect screen effort design identifi compound rapid decreas endogen c myc protein level myc amplifi cell line led discoveri compound seri phenocopi c myc knockdown sirna herein describ medicin chemistri program led discoveri potent oral bioavail c myc reduc compound develop minimum pharmacophor model base empir structur activ relationship well properti base approach use modul pharmacokinet properti highlight | D055808 | T062 |
34,669,408 | sesamol attenu amyloid peptid accumul cognit deficit appp mice mediat role gut brain axi alzheim diseas ad neurodegen diseas lead caus dementia sesamol lignan extract sesam oil found exert neuroprotect effect present studi aim investig neuroprotect effect sesamol appswepsd transgen ad mice ad mice fed diet supplement sesamol ww sesamol treatment improv spatial memori learn abil ad mice improv neuron damag decreas accumul sesamol protect synapt ultrastructur inhibit neuroinflammatori respons brain ad mice sesamol also signific inhibit overactiv microglia reduc overexpress tnf il brain ad mice notabl sesamol reshap gut microbiota signific decreas relat abund helicobact hepaticus clostridium bacillacea enhanc relat abund rikenellacea bifidobacterium ad mice found sesamol protect gut barrier integr prevent lps leakag serum import sesamol remark enhanc content scfas includ acet propion isobutyr butyr valer ad mice correl analysi indic strong correl level scfas cognit function result demonstr sesamol attenu ad relat cognit dysfunct neuroinflammatori respons could part explain role mediat gut microb scfa brain axi thus sesamol promis nutrit intervent strategi prevent ad via microbiota gut brain axi | D000544;D060825;D019636 | T048;T047 |
34,669,407 | doorway mechan electron attach induc dna strand break report new doorway mechan dissoci electron attach genet materi dipol bound state nucleotid anion act doorway electron captur genet materi electron get subsequ transfer dissoci type anion state local sugar phosphat sugar nucleobas bond lead cleavag electron transfer mediat mix electron nuclear degre freedom cleavag rate sugar phosphat bond predict new mechan higher sugar nucleobas bond break process consider slower format stabl valenc bound anion new mechan explain relat rate electron attach induc bond cleavag genet materi | D004583 | T196;T081 |
34,669,400 | self assembl phycoerythrin oligochitosan electrostat interact stabil phycoerythrin phycoerythrin pe natur water solubl pigment protein characterist phycobilin sensit thermal light environment chang studi pe extract porphyra haitanensi pe oligochitosan complex poc fabric self assembl approach effect cation oligochitosan bind interact structur size distribut color stabil pe evalu stoichiometr number n calcul oligochitosanp bind constant k cation oligochitosan could electrostat interact pe affect pe structur increas helix content addit high concentr oligochitosan led format dens phycoerythrin protein granul moreov reaction ratio oligochitosanp approxim predict stoichiometr number n thermal stabil c natur light stabil ultraviolet light irradi nm stabil poc improv studi provid approach reduc suscept pe upon environment chang form stabl self assembl complex promot applic pe natur pigment protein food chemic applic | D010799;D000461 | T116;T002;T123 |
34,669,399 | adsorpt microtit plate solid support affin purif workflow affin ligand antibodi wide use bio medic research purifi protein complex biolog sampl ligand general immobil onto solid support facilit separ captur protein sampl matrix adsorpt microtit plate common use solid support prior immunochem detect eg immunoassay hard ever prior liquid chromatographi mass spectrometri lc ms base detect describ use adsorpt microtit plate protein enrich prior lc ms detect discuss opportun challeng correspond workflow base exampl target ie solubl receptor advanc glycat end product srage human serum discoveri base workflow ie transcript factor p nf b lyse murin raw macrophag peptidyl prolyl cis tran isomeras fkbp fkbp lyse human alveolar basal epitheli cell therebi aim highlight potenti use adsorpt microtit plate affin purif workflow prior lc ms detect could increas usag mass spectrometri base protein research | D057188 | T077 |
34,669,397 | odor bind protein play crucial role olfactori respons bemisia tabaci r curcumen cultiv tomato solanum lycopersicum suffer sever attack whitefli bemisia tabaci gennadius caus damag leav feed well transmit tomato yellow leaf curl virus tylcv wild tomato habrochait consider less appeal insect speci report b tabaci show innat avoid r curcumen produc natur habrochait howev mechan involv avoid behavior b tabaci respons chiral compound still unclear yet studi function bind character odor bind protein b tabaci btobp examin vivo vitro r curcumen obtain result show btobp exhibit specif bind activ r curcumen act repel b tabaci use fluoresc base bind assay differ bind affin r curcumen wild type btobp mutant btobp r curcumen perform result singl amino acid mutat asn ser moreov btobp n display signific decreas bind affin r curcumen interest knock experi btobp show whitefli respons r curcumen impair studi illustr btobp crucial protein involv percept discrimin r curcumen find may provid excel chanc find suitabl antagonist eco friend featur block percept chemosensori signal insect prevent behavior like food find | D053839;D006430;D018551;D018035 | T116;T002;T168;T005;T192;T204 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.