PMID int64 27.8M 36.2M | Title/Abstract stringlengths 7 10.7k | MeshTerms stringlengths 7 104 | SemanticTypes stringlengths 4 84 |
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34,669,395 | effect nonhydroxyl oxygen heteroatom diethylen glycol properti furandicarboxyl acid base polyest regard polyest base biobas furandicarboxyl acid fdca work present new strategi heteroatom substitut adjust thermal gas barrier properti effect nonhydroxyl oxygen heteroatom diol properti fdca base polyest first investig combin experi molecular simul result demonstr introduct oxygen heteroatom signific influenc thermal gas barrier properti two model polym similar skeleton structur poli pentylen furandicarboxyl ppef poli diethylen glycol furandicarboxyl pdef g exhibit obvious increas order moreov show similar thermal stabil thermal oxid stabil dynam mechan analysi positron annihil lifetim spectroscopi molecular dynam simul indic gas barrier properti follow sequenc pdef ppef main due decreas chain mobil smaller fraction free volum depth analysi effect heteroatom substitut import direct signific design prepar new high glass transit temperatur novel excel gas barrier materi manipul differ heteroatom diol polyest vari properti expect | D010100;D011091 | T121;T109;T123;T122;T196 |
34,669,394 | toward select oxid contamin aqueous system presenc divers pollut water threat human health aquat ecosystem global scale centuri chemic oxid use strong oxid speci one effect technolog destruct pollut ensur safe clean water suppli howev remov increas amount pollut higher structur complex especi emerg micropollut trace concentr complic water matrix requir excess dosag oxid andor energi input result low cost effect possibl secondari pollut consequ practic signific scientif challeng achiev select oxid pollut interest water decontamin current varieti exampl concern select oxid pollut aqueous system howev systemat understand relationship origin select applic water treatment scenario well ration design catalyst select catalyt oxid still lack critic review summar state art select oxid strategi water decontamin probe origin select select result reactiv either oxid target pollut select aris access pollut oxid via adsorpt size exclus well select due interfaci electron transfer process enzymat oxid final challeng perspect briefli outlin stimul futur discuss interest select oxid water decontamin particular toward applic real scenario | D014874;D018508 | T131;T052;T057 |
34,669,391 | understand bind starch fragment granul bound starch synthas granul bound starch synthas gbss play major role chain elong biosynthesi amylos starch compon most connect long chain glucos branch point chain length distribut clds amylos affect function properti control chang appropri residu granul bound starch synthas gbss know bind gbss amylos molecular level help better determin key amino acid gbss affect clds amylos subsequ use molecular engin atomist molecular dynam simul explicit solvent dock approach use studi build model bind rice gbss amylos amylos fragment contain linear link glucos unit built repres starch fragment stabil complex interact gbss sugar differ structureconform bound free starch fragment analyz studi found starchamylos fragment glucos unit suitabl model starch bind gbss remov interdomain disulfid gbss found affect gbss starch stabil key residu could affect bind abil also indic model help ration design mutant suggest way make singl point mutat could use develop plant produc starch improv function properti | D012275;D013214 | T126;T002;T116;T168 |
34,669,386 | detect quantif enter pathogen aerosol near open wastewat canal citi poor sanit urban sanit infrastructur inadequ mani low incom countri lead presenc high concentr uncontain fecal wast stream dens popul area combin mechan aerosol airborn transport enter microb genet materi possibl set remain poor character detect quantifi enter pathogen associ gene target aerosol sampl near open wastewat canal owc impact receiv sewag wastewat surfac water control site la paz bolivia kanpur india atlanta usa via multiplex revers transcript qpcr target ddpcr target detect wide rang enter target previous report extramur urban aerosol frequent detect enter target higher densiti la paz kanpur near owc report densiti estim rang gc per air across target includ heat stabl enterotoxigen escherichia coli campylobact jejuni enteroinvas e coli shigella spp salmonella spp norovirus cryptosporidium spp estim sampl contain posit pathogen detect accompani cultur e coli la paz kanpur atlanta respect suggest potenti viabil enter microb point sampl airborn transmiss enter pathogen merit investig citi poor sanit | D003457;D003458 | T204;T047 |
34,669,385 | map glycerid speci biodiesel high temperatur gas chromatographi combin chemic ionize mass spectrometri accur comprehens identif residu glycerid biodiesel import part fuel character due impact glycerid fuel physicochem properti howev analysi bound glycerol biodiesel sampl face challeng due lack readili avail standard structur complex glycerid speci nontradit biodiesel feedstock risk misannot presenc impur gas chromatograph separ evalu methan isobutan chemic ionize singl quadrupol mass spectrometri combin high temperatur gas chromatographi separ map monoacylglycerol diacylglycerol triacylglycerol biodiesel unlik electron impact ionize produc most sourc fragment isobutan chemic ionize spectra tetramethylsilyl derivat monoacylglycerol diacylglycerol domin molecular ion sio ch ion provid import diagnost inform demonstr util isobutan chemic ionize identifi structur complex glycerolipid standard well speci biodiesel sampl differ plant anim feedstock | D056804;D005989 | T121;T109 |
34,669,384 | photochem degrad nitrocatechol dinitrophenol sugar glass secondari organ aerosol surrog role chemic environ viscos play photochem fate molecul trap atmospher particl poor understood goal work character photolysi nitrocatechol nc dinitrophenol dnp semisolid isomalt new type surrog glassi organ aerosol compar photolysi liquid water isopropanol octanol uvvi spectroscopi use monitor absorb decay determin rate photochem loss nc dnp quantum yield nc photolysi found smaller isomalt glass liquid isopropanol nc ndp much lower photolysi rate water organ matric suggest would photolyz effici organ aerosol particl cloud fog droplet liquid chromatographi tandem mass spectrometri use examin photolysi product nc isopropanol solut product appear result oxid nc stark contrast photoreduct dimer product observ solid isomalt therefor photochem fate nc presum nitrophenol depend whether undergo photodegrad liquid semisolid organ particl | D019297;D000073893 | T130;T121;T109 |
34,669,383 | red edg bilin bind photoreceptor optogenet tool fluoresc report review add bilin bind phytochrom chemic review themat issu optogenet photopharmacolog work structur two part first outlin photochemistri coval bound tetrapyrrol chromophor summar relev spectroscop kinet biochem physiolog properti differ famili phytochrom base knowledg describ engin phytochrom improv chromoprotein photoswitch review employ ever grow number differ optogenet applic applic reli light control complex format plant photoreceptor phyb phytochrom interact factor pif c termin light regul domain enzymat function present mani bacteri algal phytochrom phytochrom base optogenet tool current implement bacteria yeast plant anim achiev light control wide rang biolog activ cover regul gene express protein transport cell organell recruit phytochrom pif tag protein membran cellular compart compil illustr intrins advantag phytochrom compar photoreceptor class eg bidirect dual wavelength control enabl instant regul particular long wavelength rang absorpt fluoresc within transpar window make phytochrom attract complex applic requir deep tissu penetr dual wavelength control combin blue uv light sens photoreceptor addit wide variabl applic employ natur engin phytochrom also discuss recent progress develop bilin base fluoresc protein | D001654;D010834 | T116;T109;T123 |
34,669,381 | prff peptid mimic interfer toxic fibrin interact emul bind interfac fibrinogen cerebrovascular dysfunct common phenomenon alzheim patient fibrinogen major player blood brain barrier compromis fibrinogen gain access brain interact result plasmin resist abnorm blood clot deposit cerebr blood vessel condit common encount alzheim diseas ad patient call cerebr amyloid angiopathi caa far effect therapeut avail combat ad associ caa studi report amino acid peptid p npgrpepgsagtw potenti inhibitor fibrin interact along properti dissolv pre exist plasmin resist abnorm clot strike identifi sequenc found partial similar fragment fibrinogen chain report bind plasmin resist fibrinogen fragment prff mechanist p interact place fibrinogen thus inhibit toxic fibrin interact howev interfer normal fibrin polymer | D000544;D005341 | T116;T047;T121;T048;T126 |
34,669,379 | acceler molecular dynam explor bind transit metal amyloid report acceler molecular dynam amd simul amyloid peptid four differ length residu complex bound cu ii fe ii zn ii ns equilibr trajectori data analyz structur three independ ns amd simul generat amd trajectori show presenc metal ion lead reduc size decreas mobil relat free peptid due anchor effect ion reduc mobil shown larg due restrict movement n termin residu notabl asp involv metal ion coordin case signific disrupt secondari structur pattern salt bridg interact aris coordin metal ion regard similar note result zn ii fe ii wherea result cu ii compar free peptid reweight free energi surfac carri amd data identifi properti descript local minima structur | D000544;D056004 | T044;T048;T047;T066 |
34,669,378 | recent progress surfac modifi nanomateri scaveng reactiv oxygen speci organ reactiv oxygen speci ros essenti normal physiolog process play import role signal transduct immun tissu homeostasi howev excess ros may negat effect normal cell lead various diseas nanomateri attract therapeut altern antioxid possess intrins abil scaveng ros surfac modif nanomateri critic strategi improv comprehens perform herein review differ surfac modifi strategi nanomateri scaveng ros inher antioxid capabl mechan action biolog applic last primari challeng futur perspect emerg research frontier also highlight believ review paper offer top understand guidanc engin futur high perform surfac modifi ros scaveng nanomateri wide biomed applic | D017382 | T196;T123 |
34,669,377 | enzymeless dna base identif chemic step nanopor stepwis movement singl biopolym strand nanoscop detector sequenti identif build block offer univers mean singl molecul sequenc principl implement portabl sequenc use enzym move dna rna hundr individu nanopor detector posit array nevertheless applic sequenc biopolym includ polypeptid polysaccharid progress suitabl enzym lack recent devis pure chemic mean move molecul process step compar repeat distanc biopolym chemic approach demonstr sequenti nucleobas identif dna transloc nanopor relat locat guanin modif chemotherapeut platinum deriv pinpoint singl base resolut develop chemic transloc might replac step enzym high parallel singl molecul biopolym sequenc | D058608 | T082 |
34,669,375 | import water maintain softwood secondari cell wall nanostructur water one princip constitu mass live plant cell wall howev role interact secondari cell wall polysaccharid impact dehydr subsequ rehydr molecular architectur still elucid work combin multidimension solid state c magic angl spin mas nuclear magnet reson nmr molecular dynam model deciph role water molecular architectur softwood secondari cell wall proxim main polym molecular conform interact energi compar never dri oven dri rehydr state water shown play critic role hemicellulos cellulos interfac signific molecular shrinkag caus dehydr origin molecular conform fulli recov rehydr chang includ xylan becom close irrevers associ cellulos mannan becom mobil chang conform irrevers nanostructur chang provid basi explain improv properti wood base materi | D049329;D014867 | T121;T073;T197 |
34,669,373 | cr isotop engin attenu cr vi rich runoff leach laterit soil result drainag water high concentr cr vi cr vi rich water develop stream drain laterit soil central sulawesi island indonesia chromium laterit drainag system remov reduct cr vi cr iii two faucet deliv feso solut drainag water cr stabl isotop composit water sediment sampl along drainag path use evalu efficaci remedi strategi overal dissolv cr vi decreas move downstream increas cr vi first faucet effect remov second faucet intermitt increas cr vi like result oxid remobil sediment cr iii reaction mn oxid cr isotop distribut reflect near quantit reduct associ feso faucet also reveal cr isotop fraction impart due cr redox cycl downstream redox cycl fraction appear accompani oxid product cr vi becom enrich cr relat reactant cr iii appar fraction factor studi suggest feso effect remov cr vi drainag presenc mn oxid confound attenu improv cr vi remedi consid mean prevent back reaction cr iii mn oxid | D002857;D007554 | T131;T196 |
34,669,370 | model temperatur induc conform chang xanthan polysaccharid xanthan extracellular bacteri polysaccharid manufactur commerci ferment xanthomona campestri use extens food industri control viscos textur various product use properti stem occurr relat rigid doubl helic polym branch polym network presum crosslink noncoval interact stabil doubl helic form interconvers two form achiev heat cool process paper describ model thermal induc transform condit dilut aqueous polym concentr characterist doubl helic crosslink aggreg studi experiment use light scatter xanthan regular repeat copolym requir specif registr two strand duplex structur requir natur occur nucleic acid doubl helic demonstr import role result xanthan structur degeneraci dictat characterist temperatur induc conform transit | D011135 | T129;T109 |
34,669,369 | fluoresc sensor array quantit determin saccharid accur monitor sugar level essenti mani field food industri human health develop fret base dual chromophor sensor saccharid form oxazolidin boron may employ noninvas method monitor sugar level biolog fluid name urin saccharid bind properti sensor studi use fluoresc spectroscopi util determin saccharid high throughput manner two fluoresc sensor success classif nine differ monosaccharid disaccharid correct classif furthermor dual chromophor self assembl sensor success util quantit determin import carbohydr glucos presenc competit saccharid fructos complex media urin without sampl pretreat present fluoresc sensor allow quantif glucos concentr rang mm match concentr rang frequent use urinalysi test strip | D002241;D005947 | T121;T109;T123 |
34,669,368 | nanocatalysi nanoconfin metal free hybrid coacerv nanodroplet catalyt nanoreactor effici redox photocatalyt reaction natur util cellular subcellular compartment effici drive various complex enzymat transform via spatiotempor control context design artifici nanoreactor effici catalyt transform find tremend import recent time one key challeng remain design multipl catalyt center within confin space nanoreactor without unwant agglomer access barrier reactant herein report uniqu blend nanosci chemic catalysi use metal free hybrid synthet protocel catalyt nanoreactor redox photocatalyt transform otherwis incompat bulk aqueous medium hybrid coacerv nanodroplet nds fabric nm size carbon dot cds poli diallyldimethyl ammonium chlorid util toward reduct hydrogen nitroaren presenc sodium borohydrid nabh found reduct mechan follow classic langmuir hinshelwood lh model surfac embed cds insid nds via generat reactiv surfac hydroxyl group nds show excel recycl without compromis reaction kinet convers yield import spatiotempor control hydrogen reaction achiev use two mix popul coacerv moreov effici visibl light induc photoredox convers ferricyanid ferrocyanid artifici peroxidas like activ also demonstr insid catalyt nds find indic individu polym bound cd insid nds act catalyt center redox photocatalyt reaction present studi highlight unpreced catalyt activ metal free cd base coacerv nds pave way next generat catalyt nanoreactor wide rang chemic enzymat transform | D036103 | T090 |
34,669,363 | krppel like factor serv facilit gastric cancer progress via activ wnt catenin pathway krppel like factor klf transcript factor exhibit promot effect cervic cancer correl gastric cancer gc report yet studi explor role potenti mechan klf gc progress use seri experiment method includ rt qpcr western blot cck assay edu stain cell cycl analysi klf found elev gc tissu n compar normal tissu appli ualcan analyz dataset cancer genom atlas tcga upregul klf also valid gc cell line function studi prove rna interfer mediat silenc klf inhibit gc cell growth evidenc decreas cell viabil dna synthesi arrest cell cycl g phase moreov klf knockdown exert inhibitori effect cell migrat invas well epitheli mesenchym transit emt gc cell convers overexpress klf opposit effect gc progress furthermor prove activ wnt catenin pathway mark inhibit klf knockdown promot klf overexpress blockad wnt catenin pathway rescu effect klf overexpress result suggest klf promot growth migrat invas emt process gc cell promot achiev activ wnt catenin pathway work help search potenti therapeut target treatment gc | D060449 | T044 |
34,669,360 | valu geriatr assess patient genitourinari carcinoma object work aim evaluatecomprehens geriatr assess cga tool better guid patient urogenit carcinoma periop consequ intensifi reduc hospit resourc use method inform consent patient includ age year oncolog surgeri proof malign mini mental state examin mmse score least point prospect life expect month patient divid group prostat cancer n distal urinari tract cancer n cga tool instrument activ daili live iadl activ daili live adl charlson comorbid index cci relationship cga complic hospit durat death rate baselin characterist analyz result comparison patient prostat cancer kidneydist urinari tract cancer higher cci score median vs p mmse score vs p complic rate vs p hospit durat vs day p well death group vs comorbid vs p physic status classif system asa state vs p median age vs year p higher kidneydist urinari tract group fewer problem postop adl item signific lower prostat group p intra intergroup comparison preoper year adliadl valu differ signific conclus studi result underscor import cga patient genitourinari carcinoma patient high regen potenti patient kidneydist urinari tract cancer older comorbid postop impair patient prostat cancer | D015577 | T058 |
34,669,358 | germlin test prostat cancer test result multipl studi shown substanti proport men advanc prostat cancer carri germlin dna repair mutat germlin test prostat cancer may inform treatment decis consider clinic trial fda approv parp inhibitor parpi olaparib lynparza rucaparib rubraca treatment advanc prostat cancer dna repair defici increas demand germlin test prostat cancer shortag genet counselor creat need altern care model encourag oncologist take activ role perform germlin test articl summar recommend germlin test prostat cancer describ care model provid counsel test | D018095 | T045 |
34,669,357 | hepat associ aplast anemia etiolog clinic characterist outcom hepat associ aplast anemia haa form acquir aplast anemia aa bone marrow failur develop acut attack hepat bone marrow failur lead aa general sever case haa fatal left untreat retrospect multicent studi investig clinic laboratori characterist possibl caus treatment outcom haa children twenti patient center includ studi aspart aminotransferas alanin aminotransferas upper limit normal uln patient uln patient acut liver failur develop patient pancytopenia simultan present patient eleven patient aliv remiss transfus free aliv either undergon hematopoiet stem cell transplant andor immunosuppress treatment except patient receiv treatment patient diagnosi acut hepat evalu follow care presenc cytopenia definit treatment aa initi time appropri manner need | D000741;D018380;D006505;D017114 | T047;T061 |
34,669,350 | clinic genet aspect abca associ inherit retin diseas clinic genet characterist abca associ inherit retin diseas studi decad sinc identif abca protein abca gene abca mutat initi associ autosom recess stargardt diseas stgd establish mutat gene caus inherit retin diseas cone rod dystrophi retin pigmentosa addit phenotyp abca associ diseas vari great classic present stargardt diseas loss central vision adolesc diseas earli onset rapid progress late onset milder cours abca associ diseas inherit autosom recess manner ie diseas develop allel gene damag one inherit father inherit mother mani recess hereditari diseas character varieti clinic manifest divers phenotyp abca associ retin diseas explain combin sequenc variant abca gene inherit patient parent despit fact respect inherit retin diseas associ mutat abca gene fundament differ autosom recess trait due structur gene protein encod number featur thatshould taken account perform molecular diagnost predict possibl manifest cours diseas plan approach treatment | D012164;D012174 | T047 |
34,669,349 | new possibl diagnosi hereditari optic neuropathi studi analys data clinic genet examin patient well examin cytolog skin fibroblast patient hereditari optic neuropathi hon clinic examin reveal hon symptom studi patient primari damag retin ganglion cell accompani swell peripapillari retin nerv fiber layer rnfl acut stage diseas observ case mtdna mutat caus develop leber hereditari optic neuropathi lhon detect case includ three frequent mutat case rare candid mutat case ndna mutat associ autosom domin optic neuropathi adon case mutat dnajc ndna gene caus autosom recess optic neuropathi aron case among patient clinic pictur lhon mtdna mutat found case mutat dnajc gene ndna case cytolog studi use high resolut respirometri confirm presenc mitochondri dysfunct cell patient harbor pathogen mutat also harbor candid mutat algorithm clinic genet verif hon togeth set cytolog studi allow identif mitochondri genesi diseas indispens confirm pathogen new candid mutat | D029242;D009901 | T047 |
34,669,348 | challeng long term glaucoma therapi primari open angl glaucoma poag among common caus irrevers loss visual function earli diagnosi treatment present great difficulti poag develop involv mani mechan hemodynam metabol factor main approach treatment reduct normal intraocular pressur iop start local antihypertens therapi sinc glaucoma requir life long manag lengthi topic therapi becom caus mani serious issu often includ achiev consist normal iop system local advers event difficulti patient complianc decreas qualiti life increas risk glaucoma surgeri ophthalmolog practic research continu demonstr need chang paradigm poag treatment | D005901;D005902 | T047 |
34,669,347 | pigmentari glaucoma yesterday today tomorrow pigment dispers syndrom pds condit most affect young men myopic refract pds character presenc krukenberg spindl peripher iri defect signific trabecular meshwork pigment well convex iri configur configur caus friction iri posterior pigment layer ligament lead releas pigment accumul most structur anterior chamber time pds progress pigmentari glaucoma pg turn lead perman loss vision review analyz avail data diagnosi treatment pds pg | D005902 | T047 |
34,669,346 | modern treatment differ form optic nerv atrophi optic nerv atrophi ona one common caus blind low vision world diseas occur case caus optic nerv atrophi divers inflammatori vascular diseas optic nerv retina glaucoma atherosclerosi main vessel head neck diseas central nervous system intox various etiolog well congenit hereditari diseas literatur review present data diagnosi classif optic nerv atrophi well drug non drug treatment combin physiotherapi | D005901;D009896;D015354 | T047 |
34,669,345 | ophthalmolog manifest post covid syndrom review present data damag organ vision patient recov new coronavirus infect reflect result obtain various research examin patient vari sever diseas activ stage recoveri possibl way transmiss infecti agent organ vision analyz common ocular manifest covid conjunct lesion retina optic nerv note less often articl also outlin strategi treatment describ infect prevent measur doctor patient | D000086382;D003231 | T047;T067 |
34,669,344 | role vitreous bodi pathogenesi glaucoma literatur review provid modern inform uniqu structur vitreous bodi function role pathogenesi glaucoma describ featur vitreous morpholog metabol note biomechan trophic function outlin role healthi hydrodynam hemodynam eye well aqueous humor outflow review present clinic observ associ patholog chang vitreous bodi glaucoma develop examin role involut chang vitreous pathogenesi glaucoma articl also discuss possibl pathogenet mechan glaucoma develop term patholog chang vitreous | D005901;D014822 | T023;T047 |
34,669,343 | role neurodegener biomark manag patient diabet retinopathi literatur review focus role diseas biomark manag patient diabet retinopathi dr investig detail problem retin neurodegener patient identif assess signific qualit quantit biomark dr neurodegener complement screen examin well help predict cours diseas respons therapi comprehens analysi factor allow effect treatment prevent complic patient dr base prognost model dynam monitor indic | D003924;D003930 | T047 |
34,669,342 | modern concept pathogenesi diabet retinopathi literatur review present modern view pathogenesi diabet retinopathi dr pay particular attent molecular mechan lead develop well manifest retin neurodegener patient assess condit clinic manifest make possibl diagnos dr stage absent initi vascular chang investig neurodegener mechan could supplement exist understand diseas pathogenesi could possibl help find new way treatment prevent dr | D003920;D003930 | T047 |
34,669,341 | microaneurysm biomark diabet retinopathi diabet retinopathi microvascular patholog common complic diabet mellitus improv instrument diagnost retin patholog contribut identif various phenotyp progress ocular fundus patholog diabet base specif chang retina biomark particular microaneurysm initi describ diabet manifest wide rang system patholog retin diseas indic sever diabet retinopathi dynam chang number microaneurysm confirm prognost biomark clinic signific macular edema diabet retinopathi microaneurysm one earliest recogniz sign dynam format disappear may serv predictor diseas progress literatur review present characterist microaneurysm base various imag techniqu analys link structur featur dynam chang microaneurysm progress diabet retinopathi | D003920;D003930;D000071071 | T190;T047;T046 |
34,669,340 | static autom perimetri diagnosi glaucoma part research protocol glaucoma classif perimetr defect prism structur function correl examin central visual field current requir glaucoma diagnosi modern comput perimet make possibl qualit quantit evalu defect light sensit perimetr indic calcul show sever defect allow use perimetr result creat univers classif glaucoma recent new perimet program base optic coher tomographi data appear possibl person perimet program test review attempt systemat data capabl comput perimet assess function defect present wide use glaucoma classif describ way develop static perimetri program earlier diagnosi glaucoma respect structur function correl | D005901;D058609 | T047;T060 |
34,669,339 | static autom perimetri diagnosi glaucoma part basic principl static autom perimetri indispens tool diagnosi glaucoma use studi differenti light sensit retina differ point visual field import central zone visual field mani perimetr program strategi develop examin use standard background bright vari size locat method type stimulus deliveri proper use standard achromat perimetri crucial correct manag glaucoma patient review analyz literatur basic principl static perimetri examin differenti photosensit retina | D005901;D058609 | T047;T060 |
34,669,338 | result optic coher tomographi retina optic nerv keratoconus articl review result optic coher tomographi oct retina optic nerv patient keratoconus kc research direct premis possibl chang retina optic nerv associ kc well potenti influenc signific chang axial eye length disord corneal refract increas level aberr qualiti visual ocular structur result conduct studi conflict indic possibl oct find alter kc patient therefor question chang paramet oct retina optic nerv requir investig main problem need solv evid base medic research phrase follow chang oct find observ kc patient consequ chang retina optic nerv associ disord potenti effect aberr irregular astigmat qualiti visual studi structur | D001251;D007640 | T047 |
34,669,337 | current trend studi pathogenesi glaucoma glaucoma group neurodegen disord compris one main caus irrevers blind glaucoma relat blind global relev problem mani aspect glaucoma pathogenesi studi impact increas intraocular pressur iop develop optic neuropathi ischemia reperfus retina direct mechan neuron death excitotox oxid stress etc howev effect glaucoma treatment lower iop earli glaucoma diagnosi base determin structur function retin defect therefor import emphas research insuffici studi aspect glaucoma pathogenesi neuroinflamm translaminar pressur genet factor associ glaucomat damag chang brain mitochondri patholog other articl review perspect direct research pathogenesi glaucomat optic neuropathi | D005901;D009901 | T047 |
34,669,336 | pharmacolog physiotherapeut method treat non exud age relat macular degener non exud form age relat macular degener amd diseas long term progress effect treatment found mani studi conduct find effect drug prevent appear drusen increas rpe atrophi area could help avoid danger form amd main drug nutraceut use treat dri form amd lutein zeaxanthin omega fatti acid addit treatment may includ nanosecond laser therapi drusen advanc amd panretin subthreshold micropuls laser exposur atroph amd well microcurr stimul research area aim understand pathogenet mechan associ develop amd develop new approach treatment diseas includ physiotherapi | D057092;D008268;D015593 | T047 |
34,669,335 | coeffici biomechan stress assess degre intraocular pressur compens intraocular pressur one modifi factor correct assess normal initi treatment glaucoma accuraci measur tradit method depend biomechan properti fibrous tunic eye modern clinic practic success studi method bidirect applan cornea use ocular respons analyz ora mathemat integr paramet measur make possibl calcul coeffici biomechan stress k bs character chang fibrous tunic eye induc intraocular pressur serv criterion intraocular pressur compens | D005901;D007429 | T047;T042 |
34,669,334 | function multislic comput tomographi orbit diagnosi incomit strabismus studi valu function multislic comput tomographi msct orbit examin patient complex incomit strabismus | D009915;D013285 | T047;T030 |
34,669,333 | antibacteri effect antisept picloxydin dihydrochlorid conjunctiv isol gram negat bacteria preoper postop use antisept altern antibiot repeat cours anti vegf therapi reduc risk develop antibiot resist eye microflora among gram negat bacteria frequent isol pathogen caus eye infect pseudomona aeruginosa character reduc sensit antibiot disinfect | D000891 | T121 |
34,669,332 | state corneal nerv fiber system amyloidosi term system amyloidosi unit group diseas singl pathogenet mechan involv diffus deposit patholog fibrillar protein amyloid intercellular space various organ among system form amyloidosi light chain amyloidosi al amyloidosi occur often clinic practic transthyretin amyloidosi ttr amyloidosi common hereditari form laser corneal confoc microscopi ccm allow vivo non invas assess state corneal nerv fiber cnf | D028227;D009412 | T026;T023;T047 |
34,669,331 | precorn tear film corneal collagen cross link keratoconus preliminari report studi condit precorn tear film keratoconus patient corneal collagen cross link cxl | D007640;D010778 | T047;T061 |
34,669,330 | associ polymorph marker rs trim gene rs ptpn gene risk develop exogen dri eye syndrom age technolog advanc increas number peopl expos extern risk factor damag ocular surfac wear contact lens electromagnet radiat comput mobil devic etc howev presenc extern factor lead risk develop dri eye diseas ded trigger mechan develop autoimmun lesion ocular environ system diseas known associ molecular genet factor search molecular genet disord base analysi polymorph marker number gene respons state eye surfac | D003261;D015352 | T047;T074;T184 |
34,669,329 | femtosecond laser assist phacoemulsif hypermatur cataract patient len sublux studi modern capabl femtosecond laser treatment complic cataract topic problem cataract surgeri | D002386;D007906;D007910;D018918 | T047;T074;T190;T037;T061;T033 |
34,669,328 | confoc microscopi diagnosi acanthamoeba kerat acanthamoeba kerat ak danger diseas cornea preval increas signific due widespread usag contact lens similar clinic manifest ak infecti kerat especi herpet kerat requir introduct rapid diagnosi method clinic practic | D000048;D015823;D003261 | T204;T047;T074 |
34,669,327 | evalu effect organ preserv treatment choroid melanoma optic coher tomographi find achiev local tumor control general consid criterion effect organ preserv treatment case assess ophthalmoscopi ultrasonographi howev presenc pigment area difficult interpret ophthalmoscopi ultrasonographi find work concern inform optic coher tomographi oct organ preserv treatment choroid melanoma cm general cover complic post radiat maculopathi neuropathi identif vitreomacular traction evalu local control attent paid presenc subretin fluid andor retin pigment epithelium rpe detach | D002830;D008545 | T191 |
34,669,326 | scan electron microscopi result vitreous bodi asteroid hyalosi evalu structur vitreous bodi asteroid hyalosi low vacuum scan electron microscopi | D005128;D012164 | T047 |
34,669,325 | surgic treatment hypermatur cataract patient len sublux small pupil studi possibl hybrid femtosecond laser assist phacoemulsif complic situat relev problem cataract surgeri | D002386;D007906;D018918 | T047;T190;T061;T037;T033 |
34,669,324 | recognit manag pediatr travel associ infecti diseas emerg depart global travel made travel associ infecti diseas taid frequent consider pediatr emerg depart studi show physician may either omit travel histori even posit travel histori consid potenti serious ill dengu malaria thorough travel histori includ purpos locat activ diet exposur help emerg clinician develop narrow differenti diagnosi issu review epidemiolog clinic present diagnosi manag various taid goal earli recognit diseas specif treatment | D003715;D008288 | T047 |
34,669,323 | hypertens associ hear health problem among canadian adult age year hypertens common condit experienc close one quarter adult popul canada evid condit medic use treat may lead hear health problem defin studi hear loss tinnitus condit | D034381;D006973;D014012 | T033;T047;T184;T037 |
34,669,322 | mortal among first nation peopl first nation peopl report shorter life expect like non indigen counterpart die prematur avoid caus | D007198 | T098 |
34,669,320 | evalu diabet self manag educ geriatr type diabet turkey studi conduct evalu diabet educ effici individu year old turkey highest preval diabet europ | D003924;D005853;D000073278 | T091;T058;T047;T090 |
34,669,317 | emerg depart manag rib fractur rib fractur result blunt thorac trauma often associ life threaten complic injuri cardiorespiratori system given risk morbid mortal emerg clinician must swift thorough diagnos manag injuri societi guidelin publish assist determin best practic approach pain control imag treatment issu review recent studi evid multimod pain control decis tool diagnost imag ventilatori support oper fixat score system determin disposit patient evalu particular attent given special risk elder patient | D012253;D013898;D014949 | T037 |
34,669,312 | steroidi tra necessit e tossicit steroid minim alway one desir goal regard immunosuppress therapi renal transplant follow introduct cyclosporin differ steroid free protocol becam avail implement limit due high risk acut reject last year use low dose prednison mgday deem guarante good balanc steroid toxic efficaci howev high interpati variabl prednisolon exposur prevent standard low dose safe expect patient therefor steroid side effect still observ variabl percentag patient set person steroid dosag might prevent exposur drug strategi avail yet thus steroid withdraw remain avail strategi limit side effect last year learn steroid free protocol associ higher risk acut reject reduc graft surviv henc patient higher risk acut reject recurr primari renal diseas usual exclud protocol earli steroid withdraw within day transplant wide use also suggest american guidelin howev steroid withdraw month transplant prefer mani author deem equal effici addit earli late steroid withdraw alway associ induct therapi last tacrolimus plus mycophenol acid becom use associ steroid minim protocol | D006084;D007166;D013256 | T129;T042;T121;T109 |
34,669,306 | environment toxic direct drug relat renal toxic antibiot antibiot relat common caus acut kidney injuri occur main patient under risk factor advers reaction antibiot classifi type forese know caus often dose depend type b occur unpredict way independ dose due hypersensit immunoallerg phenomena compart kidney prone antibiot damag clinic result tubular dysfunct acut renal failur nephrit syndrom chronic renal failur drug respons vancomycin aminoglycosid beta lactamin occurr acut renal failur correl length hospit risk death therefor becom fundament clinic import know antibiot potenti nephrotox effect order establish dosag basi renal function correct factor enhanc toxic | D058186;D004364 | T047;T121;T037 |
34,669,304 | drogh dabuso e rene present case acut renal failur need dialysi heroin addict patient chronic treat metadon give us opportun review renal effect main drug abus highlight shift occur four old sister marijuana cocain heroin amphetamin news synthet drug chiefli synthet cathinon cannabinoid pose problem due larg diffus easi procur legal non regul difficult analyt identif rais medic forens question nephrolog point view essenti take great care need diagnos kind patholog widen search tri anyway recogn substanc potenti involv | D058186;D003042;D019966 | T047;T121;T109;T131;T048;T037;T033 |
34,669,303 | environment toxic direct renal toxic drug herb plant tradit medicin widespread treatment method world despit confirm progress spread nation polici respons control product distribut phytotherapi risk toxic side effect high even real incid known risk larg result self prescript support assumpt natur danger health phytotherap industri turnov progress increas favor eas product purchas without prescript pharmaci countri onlin particular chines herb nephrotox clinician consid possibl role case aki ckd unknown etiolog furthermor collect pharmacolog histori patient ckd kidney transplant necessari exclud use phytotherap common use may contraind possibl interact drug convent medicin | D064420;D008517 | T061;T046;T037 |
34,669,295 | news progest gynaecolog progesteron p steroid primarili secret corpus luteum placenta adren gland play essenti role femal reproduct function progestin ps synthet analogu p specif steroid receptor affin progestin pill pop antimineralocorticoid effect recent market toler safeti profil superior exist pop contrast ps antiandrogen properti use high dose treatment hirsut associ increas meningioma risk new clinic fundament data open path research therapeut use p cognit neuroprotect bone | D006176 | T091 |
34,669,294 | obstetr anal sphincter injuri manag subsequ deliveri obstetr anal sphincter injuri oasi complic vagin deliveri potenti consequ numer includ anal andor fecal incontin sexual problem perin pain aggrav futur pregnanc childbirth one common issu oasi assess anorect function discuss deliveri modal next pregnanc dedic assess includ clinic paraclin evalu ultrasound andor manometri person assess patient histori sphincter injuri allow detail discuss decid rout deliveri inform manner | D001003;D005242 | T047;T023;T184;T030 |
34,669,293 | telemedicin matern health time covid five nation intern project telemedicin matern health consist use remot communic reach diagnos treat follow patient context pre post natal care covid acceler use telemedicin obstetr divis hug develop five project geneva low resourc zone world object improv access qualiti care base experi applic telemedicin matern health problem shown three major advantag improv access care standard procedur acceler speed intervent howev effect telemedicin requir health staff good level medic comput skill well fluid communic among particip constant follow inform flow | D000086382;D017216 | T058;T047;T067 |
34,669,292 | contribut use virtual realiti childbirth narrat review literatur current use virtual realiti vr medicin expand rapid non pharmacolog option increas propos primari complementarymultimod analges anxiolyt manag role vr obstetr remain defin propos narrat review literatur role vr obstetr childbirth show promis use proper techniqu could help improv experi childbirth | D009774;D000076142 | T091;T066 |
34,669,291 | vitamin pregnanc vitamin defici affect half general popul pregnanc vitamin insuffici associ higher risk complic increas incid miscarriag preterm deliveri preeclampsia gestat diabet growth retard low birth weight well postpartum hemorrhag patholog whose incid seem increas hypovitaminosi could link pregnanc chang immun system vitamin play well known modul role substitut even benefit clear establish consid side effect although lack evid regard time introduct treatment substitut may propos concept | D011248;D047928;D014808 | T047;T046 |
34,669,290 | equiti care gynecolog obstetr deaf hard hear issu deaf hard hear popul suffer difficulti access health care system due communic barrier health care administr personnel often insuffici train deaf issu gynecolog obstetr consult repres gateway health system sinc gynecolog obstetr consult dedic deaf peopl chuv articl present mean communic support put place within context specif consult well experi group patient awar deaf among staff contact patient well use profession interpret key element care respect need right deaf peopl | D003638;D006176;D034381;D009774 | T091;T033;T047;T184 |
34,669,288 | molecular character multiresist enterobacteria two depart peruvian jungl introduct emerg multiresist enterobacteria produc extendedspectrum beta lactamas esbl outpati urinari tract infect repres public health problem per object character multiresist enterobacteria isol patient diagnos urinari tract infect two peruvian jungl depart use molecular techniqu materi method conduct descript observ retrospect studi urin cultur isol two depart peruvian jungl resist profil identifi use microscan autom system convent polymeras chain reaction pcr use detect blactx blatem blashv gene result common posit esbl enterobacteria depart escherichia coli madr de dio ucayali gene blactx preval depart follow blatem blashv antimicrobi suscept profil detect resist level ampicillin cephalothin nitrofurantoin conclus blee produc multi resist enterobacteria strain depart blactx common gene | D004927;D014552 | T047 |
34,669,287 | distribut phenotyp genotyp character listeria monocytogen isol food colombia introduct listeria monocytogen food born pathogen may caus infect human mening meningoenceph septicemia well abort serolog type serotyp identifi b respons outbreak world object determin frequenc distribut serotyp molecular subtyp l monocytogen isol colombia food materi method conduct retrospect descript studi base analysi isol confirm l monocytogen speci use biochem serolog test puls field gel electrophoresi pfge molecular subtyp result isol receiv confirm l monocytogen serotyp found b e c b b c c e less isol came bogot antioquia vall nario depart genotyp character group isol pfge pattern frequent pattern identifi various dairi meat product prepar food conclus isol correspond l monocytogen show good agreement isol identif serotyp b high virul frequent molecular analysi show possibl dissemin perman time sever serotyp highlight import includ pathogen epidemiolog food surveil program | D008089;D008088 | T007;T047 |
34,669,286 | preval intestin parasit cohort hivinfect patient antioquia colombia hiv infect still public health problem worldwid co infect infecti agent includ intestin parasit particular concern main develop countri like colombia | D003457;D003458;D015658;D007411;D010271 | T204;T047 |
34,669,285 | sociodemograph clinic characterist gestat syphili cali introduct gestat syphili consid event public health interest given impact mother child colombia despit specif protocol notif diagnosi manag still limit control object describ sociodemograph clinic characterist well spatial distribut gestat syphili cali colombia materi method conduct cross section studi gestat syphili case report colombian nation epidemiolog surveil system sivigila statist process use r program version express qualit variabl proport quantit one central tendenc dispers measur establish spatial distribut use qgis program version result preval gestat syphili case per live birth includ stillbirth patient belong subsid healthcar system health insur case diagnos pregnanc pregnant women receiv three dose penicillin yet contact treat conclus preval gestat syphili cali exceed nation rate higher frequenc among women socioeconom vulner condit consist general spatial distribut lack opportun earli detect manag infect among pregnant women contact hinder control diseas reflect inadequ applic comprehens matern perinat health care rout guidelin | D011251;D013587;D013590 | T047;T019 |
34,669,284 | character sexual transmit infect pharmacolog treatment recurr colombian popul sexual transmit infect public health problem worldwid inadequ antimicrobi manag associ higher risk recurr | D012749 | T047 |
34,669,283 | indirect effect sar cov pandem preval breastfeed model impact breastfeed protect effect acut respiratori diarrheal infect psycholog social effect due physic isol popul mother child group | D058873 | T067 |
34,669,282 | frequenc antibodi seroconvers rickettsia spp patient consult health institut depart calda colombia introduct rickettsios zoonot diseas transmit arthropod act vector reservoir diseas symptom nonspecif therefor clinic diagnosi difficult indirect immunofluoresc ifa gold standard assay diagnosi interest conduct studi patholog resurfac colombia sinc besid previous studi evidenc case rickettsiosi north depart calda object establish frequenc antibodi seroconvers rickettsia spp patient consult health institut calda colombia materi method conduct quantit observ descript studi non probabilist sampl patient symptom compat rickettsiosi consult differ municip calda colombia ifa perform detect antibodi acut convalesc phase rickettsia rickettsii rickettsia typhi rickettsia feli result averag age patient year municip highest proport seroposit case belalczar chinchin filadelfia la dorada la merc manizal patient own pet report arthropod bite frequent sign symptom headach arthromyalgia fever igg seropreval r rickettsii r typhi r feli eight patient present seroconvers conclus found evid circul rickettsia speci spot fever group typhus group associ human case calda | D012281;D012282 | T007;T047 |
34,669,281 | immun character colombian famili cluster sar cov infect immunolog marker describ covid persist recoveri immun marker associ clinic featur among sarscov infect individu nevertheless studi report comprehens analysi immun chang occur sar cov infect still limit | D007694;D013601 | T025 |
34,669,280 | hiv women year analysi administr data depart colombian pacif region introduct hiv public health problem relev colombian pacif due major social problem region women expos risk factor object describ differ gender age frequent icd code relat hiv four depart colombian pacif region period materi method conduct descript retrospect observ studi ecolog unit analysi depart municip obtain aggreg data sourc sispro platform mandatori registr health servic countri age group territori entiti estim proport code women men well absolut differ femal proport minus male proport result region level predomin women group evalu largest absolut differ age group five nine age group predomin women repres age year greatest differ found age group choc smallest differ found age group nario analysi identifi follow two pattern age predomin men age predomin women conclus secondari analysi databas routin inform collect use given data show preval older adult especi women import consid includ popul promot prevent strategi hiv program | D015658 | T047 |
34,669,279 | sentinel surveil bacteri pneumonia mening children age tertiari pediatr hospit colombia bacteri pneumonia mening vaccin prevent diseas sentinel surveil provid relev inform behavior | D016920;D018410 | T047 |
34,669,278 | knowledg attitud practic relat covid among patient hospit universitario de caraca triag tent cross section studi studi knowledg attitud practic kap regard covid help identifi erron concept inadequ practic relat diseas baselin inform essenti design effect strategi improv adher prevent measur | D007722 | T053 |
34,669,277 | healthi diseas marmato gold mine th centuri smallpox plagu war thousand day mine great influenc human societi permeat rich soil cultur equal proport led profound chang individu dedic work locat take place histor review describ socio cultur health characterist well diseas associ gold mine marmato calda th centuri poor salubr condit tropic infecti diseas constant whole centuri | D003141;D010930;D012899 | T047 |
34,669,276 | comment articl regard bicentenni independ colombia read practic antonio nario develop presum effect vaccin smallpox american coloni smallpox impli process dramat destabil sociodemograph dynam explain scientif develop took place around causat virus book smallpox nario librari tool fight smallpox undertaken found father review articl bicentenni independ colombia read practic antonio nario develop vaccin presum effect smallpox set studi antonio nario medic knowledg approach work nario use educ smallpox develop biograph sketch analyz process variol kingdom nueva granada need manufactur vaccin local | D012899;D012900;D014612 | T129;T047;T121;T116 |
34,669,275 | pitfal peril surviv analysi incorrect assumpt case covid data non parametr surviv analysi becom popular statist method current medic research howev resort surviv analysi fundament assumpt fulfil sever bias result current hundr clinic studi use surviv method investig factor potenti associ prognosi coronavirus diseas covid test new prevent therapeut strategi pandem era critic ever base decis make evid reli solid statist method alway case serious methodolog error identifi recent semin studi covid one report outcom patient treat remdesivir anoth one epidemiolog clinic cours outcom critic ill patient high qualiti evid essenti inform clinician optim covid therapi policymak true effect prevent measur aim tackl pandem though time evid need encourag appropri applic surviv analysi method care peer review avoid publish flaw result could affect decis make paper recapitul basic assumpt under non parametr surviv analysi frequent error applic discuss handl data covid | D003627;D053208;D058873 | T067;T081 |
34,669,274 | bacteremia bacillus clausii administr treatment acut diarrhea case report bacillus clausii gram posit rod use probiot treat diarrhea side effect antibiot pseudomembran coliti report case b clausii bacteremia non immunocompromis patient activ peptic ulcer diseas acut diarrhea probiot administ patient hospit due diarrhea infecti origin b clausii identifi bloodstream patient matrix assist laser desorpt ionize time flight maldi tof day discharg given wide use probiot alert clinician consid microorgan causat agent sign system infect metabol compromis hemodynam instabl establish administr pathogen identifi could explain clinic cours | D000070019;D016470;D019936 | T007;T047 |
34,669,273 | mri find extrapulmonari tuberculosi pediatr patient pulmonari tuberculosi common children extrapulmonari manifest present case present case indigen girl dissemin tuberculosi pulmonari brain medullari musculoskelet substanti neurodevelopment sequela case exemplifi spectrum pediatr extrapulmonari tuberculosi endem develop countri furthermor show sever high disabl neurolog complic stress import radiolog imag guid diagnost suspicion extrapulmonari involv | D014391;D014394;D014397 | T047 |
34,669,264 | immunohistochem detect enterovirus pancreat tissu patient type diabet use polyclon antibodi proteas coxsackievirus need antiserum immunohistochem ihc detect enterovirus ev formaldehyd fix paraffin embed sampl increas gold standard monoclon antibodi clone ev envelop protein vp proven cross react protein anoth candid marker ev protein proteas pro encod ev gene translat host cell ev replic particip process proprotein viral capsid protein | D003922;D004770 | T047;T005 |
34,669,263 | raman spectroscopi base water measur identifi origin mri signal human articular cartilag zone predict histopatholog score investig first time zonal depend water distribut articular cartilag raman spectroscopi rs investig associ histopatholog score rs magnet reson imag mri base water measur cadaver human cartilag plug n differ osteoarthr oa sever use water content distribut cartilag zone probe use rs mri base techniqu histopatholog score perform two independ observ blind moder associ exist rs mri base water measur across cartilag zone rs base analysi differ water compart help assign origin signal collect various cartilag zone rs base water paramet signific correl oa sever score wherea mri base water measur rs probe differ water compart cartilag zone predict variat observ histopatholog score rs base water measur could develop assess cartilag qualiti clinic | D002358;D010003 | T047;T024 |
34,669,261 | n demethyl metabolit u activ parent compound vitro opioid receptor activ n desmethyl u n n bisdesmethyl u studi tissu distribut new synthet opioid u main metabolit n desmethyl u reveal sixfold higher metabolit concentr pig brain compar parent compound better assess toxic potenti drug aim studi assess vitro opioid receptor mor activ potenti main metabolit u n desmethyl u n n bisdesmethyl u use live cell base report assay base nanoluc binari technolog cell stabli express human mor arrestin arr fuse via flexibl linker two complementari inact subunit nanoluciferas seed poli lysin coat well plate treat n desmethyl u n n bisdesmethyl u u hydromorphon refer standard mor activ result function complement nanoluciferas assess via luminesc monitor potenc metabolit lower u ec nm u nm n desmethyl u n n bisdesmethyl u maxim efficaci e max observ relat hydromorphon set arbitrarili decreas u n desmethyl u n n bisdesmethyl u respect thus loss one two methyl group reduc mor activ potenti pronounc methyl group remov thus anticip impact mor exert higher metabolit concentr brain littl relev strong toxic effect u | D001549;D004091 | T121;T109 |
34,669,260 | enhanc inpati ward learn environ practic guid inpati ward placement rich practic learn opportun medic student howev mani opportun go overlook underus newli qualifi doctor often feel underprepar work ward improv student experi ward placement address although requir activ effort student clinic educ arduous mutual benefit improv medic educ simultan reduc staff workload present guid teacher student highlight three key area ward learn may improv strategi drive activ learn integr student ward team underutilis resourc develop patient centr approach | D004504;D013337 | T097;T065 |
34,669,259 | interprofession learn medic safeti safe medic manag requir collabor health profession | D013338;D013339 | T097 |
34,669,258 | molecular analysi sugar transport glycolysi pathway ettlia sp heterotrophi use fructos glucos fructophil behavior microalga rare trait could benefit biorefineri enabl substitut carbon sourc fructos previous studi identifi ettlia sp prefer fructos relat glucos studi analyz transcript level gene relat sugar transport glycolysi pathway fructos util ettlia sp investig fructos contain medium express level fructokinas ettfrk glucokinas ettgck ettgck gene signific upregul heterotroph cultiv ettlia sp fructos supplement condit sugar transport ettstf signific upregul fold day increas analog specif growth rate exhibit speci subsequ cultiv test multi sugar sourc also show signific upregul ettstf relat treatment without fructos phylogenet tree deriv analysi differ transport interest identifi ettstf adjac refer fructos transport high bootstrap valu given transmembran domain ettstf analog refer fructos transport gene ettstf appear play critic role fructos consumpt metabol ettlia sp | D005632;D005947 | T121;T109;T123 |
34,669,257 | lysi hi c method studi polymicrobi communiti edna microb interact natur communiti spatial structur manner particular biofilm polymicrobi infect next generat sequenc approach provid power insight divers metabol capac mutat profil communiti general fail recov situ spatial proxim distinct genotyp interactom hi c promis method assist analys complex microbiom creat chromatin cross link cell aid identifi adjac dna improv de novo assembl studi explor modifi hi c approach involv initi lysi phase prior dna cross link test whether adjac cell chromatin cross link anticip could provid new avenu studi spatial mutat dynam structur microbi communiti artifici polymicrobi mixtur pseudomona aeruginosa staphylococcus aureus escherichia coli lyse h prepar hi c murin biofilm infect model treat sonic mechan lysi chemic lysi hi c bioinformat analys result hi c interspeci chromatin link show microbi speci differ one anoth general lysi signific increas link speci increas distanc hi c link within speci also increas novel plasmid chromosom link success modifi lysi hi c protocol creat extracellular dna link promis first step toward new lysi hi c base method recov genotyp microgeographi polymicrobi communiti potenti futur applic diseas local resist cystic fibrosi lung infect chronic diabet ulcer | D003550;D011550 | T007;T047 |
34,669,256 | coalesc base speci delimit meet deep learn insight high fragment cactus system delimit speci boundari major goal evolutionari biolog increas volum literatur focus challeng investig cryptic divers within complex evolutionari scenario speciat includ gene flow demograph fluctuat new method base model select approxim bayesian comput approxim likelihood machin learn promis tool aris field introduc framework speci delimit use multispeci coalesc model coupl deep learn algorithm base convolut neural network cnns compar strategi similar abc approach appli method test speci boundari hypothes base current previous taxonom delimit well genet data sequenc loci pilosocereus aurisetus cactus speci complex sky island distribut taxonom uncertainti valid method also appli strategi data wide accept speci genus drosophila result show cnn approach high capac distinguish among simul speci delimit scenario higher accuraci abc cactus data set splitter hypothesi without gene flow show highest probabl cnn abc approach result agre previous taxonom classif line sky island distribut low dispers p aurisetus result highlight cryptic divers within p aurisetus complex show cnns promis approach distinguish complex evolutionari histori even outperform accuraci model base approach abc | D029421;D000077321 | T066;T002 |
34,669,252 | facilit health profession educ research develop action research approach educ research scholarship advanc teach knowledg practic westmead health precinct australia educ research occur isol pocket littl profession develop support develop cours introduc practic educ research multidisciplinari health profession educ | D003479;D004517 | T065;T170 |
34,669,251 | immun respons silk sericin fibroin composit potenti immunogen element altern immunomodul uniqu properti silk protein sps particular silk sericin ss silk fibroin sf attract attent design scaffold tissu engin past decad sinc sf good mechan properti ss display bioactiv scaffold combin protein exhibit complementari properti enhanc potenti materi unfortun ss sf composit generat chronic immun respons immunogen element complet clear potenti ss sf composit tissu engin element may contribut immunogen altern prepar design modul immun respons take advantag use properti discuss review known ss enhanc sheet format sf may act hydrophob region strong affin adsorpt protein induc chronic recruit inflammatori cell therefor tailor exposur hydrophob region scaffold surfac repres viabl strategi modul immun respons achiev coat ss sf composit ss hydrophil polym take advantag antibiofoul properti research still need realiz full potenti composit tissu engin | D005349;D047030 | T116;T121;T123 |
34,669,250 | predict engin class terpen synthas use experiment comput approach terpenoid high divers group natur product consider industri interest increas engin microb use product terpenoid replac natur extract chemic synthesi terpen synthas tss show high level function plastic respons vast structur divers observ natur terpenoid relat inert activ site guid intrins reactiv linear carboc intermedi along one mani cyclis path via exert subtl steric electrostat control due absenc strong protein interact intermedi remark lack sequenc function relationship within ts famili make product outcom predict sequenc alon challeng combin fact mani tss produc multipl product singl substrat hamper design use tss biomanufactur terpenoid review highlight recent advanc genom mine comput model high throughput screen machin learn allow predict engin fascin enzym near futur | D019883 | T116;T126 |
34,669,248 | synthet co cultur autotroph clostridium carboxidivoran chain elong clostridium kluyveri monitor flow cytometri synga ferment acetogen known produc main acet ethanol effici co cultur chain elong bacteria make use product promis approach produc longer chain alcohol synthet co cultur ident initi cell concentr clostridium carboxidivoran clostridium kluyveri studi batch oper stir tank bioreactor continu coco gass monitor cell count clostridia flow cytometri fluoresc situ hybrid fish fc mbar co chain elong activ observ ph although growth c kluyveri restrict organ acid produc c kluyveri reduc c carboxidivoran correspond alcohol butanol hexanol result threefold increas final butanol concentr enabl hexanol product compar mono cultur c carboxidivoran mbar co growth c kluyveri improv howev capac c carboxidivoran form alcohol reduc accumul organ acid constant decay c carboxidivoran observ measur individu cell concentr co cultur establish studi may serv effect tool knowledg base identif optimum process condit enhanc format longer chain alcohol clostridi co cultur | D047010 | T007 |
34,669,246 | sex specif neurotox dietari advanc glycat end product appp mice protect role trehalos inhibit tau phosphoryl via gsk tfeb remain unclear whether dietari advanc glycat end product dage induc cognit impair sex depend trehalos may antagon dage induc neurotox via glycogen synthas kinas beta gsk transcript factor eb tfeb signal | D014199;D016875 | T116;T121;T109;T123 |
34,669,245 | patent landscap report dental implant technic analysi signific research develop r conduct make best dental implant develop various patent applic registr studi evalu current status patent dental implant identifi futur direct r progress | D015921 | T074 |
34,669,243 | malnutrit biliari atresia assess manag outcom children biliari atresia ba particular infant high risk malnutrit attribut multitud factor includ poor oral intak intoler enter feed fat malabsorpt abnorm nutrient metabol increas calor demand malnutrit sarcopenia negat impact outcom ba lead higher pretranspl posttranspl morbid mortal review summar factor contribut nutrit defici ba offer organ approach assess manag malnutrit vulner popul | D001656;D016031;D044342;D055948 | T047;T019;T061 |
34,669,242 | perspect review applic polyacrylonitril base support laccas immobil use laccas appli bioremedi process increas studi given urgent need overcom environment problem caus emerg contamin known immobil enzym better oper stabil reaction condit allow greater applic howev given lack commerci avail immobil laccas search immobil materi method continu gain effort use polyacrylonitril pan immobil enzym investig sinc low cost materi modifi function well interact enzym polym use differ morpholog fiber bead core shell present easili applic altern review present miss link polym enzym overview pan current use support laccas immobil polym function method consid import immobil laccas sever industri sector | D004800;D042845 | T130;T116;T126 |
34,669,239 | couplelink onlin intervent young coupl face breast cancer randomis control trial young women breast cancer partner distress coupl affect later life dyadic intervent context cancer promis access barrier particular younger coupl studi evalu couplelink profession facilit web base program design help coupl improv conjoint cope | D001943;D000079382 | T058;T191 |
34,669,238 | intrins acquir drug resist lsd inhibitor small cell lung cancer occur tead driven transcript state small cell lung cancer sclc heterogen diseas consist intratumor intertumor neuroendocrin ascl andor neurod mesenchym like yap driven transcript state lysin specif demethylas lsd also known kdma inhibitor recent progress clinic trial sclc base promis preclin antitumor activ potenti clinic limit lsd inhibitor heterogen drug respons observ sclc cell line patient deriv model base observ studi molecular transcript signatur predict patient respons class drug employ sclc patient deriv transcript signatur defin sclc cell line sensit lsd inhibitor enrich neuroendocrin transcript marker wherea cell line enrich mesenchym like transcript program demonstr intrins resist lsd inhibitor identifi revers adapt resist mechan lsd inhibitor epigenet reprogram tead driven mesenchym like state data suggest segment sclc patient defin neuroendocrin differenti state like benefit lsd inhibitor provid novel evid select tead driven mesenchym like subpopul resist lsd inhibitor sclc patient may requir effect drug combin sustain effect clinic respons | D008175;D055752 | T191 |
34,669,237 | scissor shape photochrom dyad hierarch self assembl photorespons properti uniqu relationship hierarch organ biolog nanostructur function motiv chemist construct sophist artifici nanostructur system small simpl synthet molecul self assembl one sophist system investig scissor shape photochrom dyad hierarch self assembl discret nanostructur show photorespons properti synthes various azobenzen dyad found dyad adopt intramolecular fold conform like close scissor self assembl toroid nanostructur generat curvatur toroid organ nanotub helic supramolecular fiber depend natur alkyl substitu nanostructur dissoci reorgan photoisomer azobenzen unit hand introduct stilben chromophor instead azobenzen lead one dimension supramolecular polymer upon intramolecular photocycl stilben chromophor shift curv self assembl lead helicoid fiber distinct supramolecular chiral | D049329 | T073 |
34,669,236 | essenti oil piper caldens c dc piper xylosteoid kunth steud season variat chemic composit antimicrobi activ essenti oil eo chemic composit affect sever environment factor impact desir biolog activ sens work aim evalu season variat chemic composit antimicrobi activ piper caldens piper xylosteoid leav eo chemic composit determin gcms gc fid analys result identif eighti compound p caldens eo main consist sesquiterpen hydrocarbon wherea p xylosteoid eo monoterpen hydrocarbon predomin eo speci strong inhibit b subtili mic mg ml p caldens eo show strong activ aureus mic mg ml p caldens spring eo show broadest spectrum antimicrobi action amongst sampl speci pca season differenti eo chemic composit addit expect pca sampl show distinct two speci studi success demonstr import evalu season variat eo chemic composit antimicrobi activ obtain product desir properti | D012621 | T079 |
34,669,235 | dynam cell death across growth stage diel cycl dinoflagel karenia brevi recent evid suggest program cell death pcd play role stress induc declin termin harm algal bloom howev compon pcd cascad ie reactiv oxygen speci ros caspas like activ also observ absenc exogen stress activ function remain unclear character variabl preval cell death ros caspas like activ differ growth phase diel cycl cultur dinoflagel karenia brevi result show ros percentag increas cultur age fluctuat phase diel pattern caspas like activ observ throughout growth activ grow k brevi cell pcd compon may involv key metabol process stationari phase may relat stress acclim circadian diel pattern ros may explain balanc metabol generat ros circadian rhythmic antioxid enzym overal work highlight involv pcd compon growth marin phytoplankton import understand mechan control accumul would help better interpret presenc field | D004141 | T204 |
34,669,233 | ablat arginyl trna protein transferas oligodendrocyt impair central nervous system myelin addit arginin arg trna caus major alter structur function protein substrat post translat modif term protein arginyl mediat enzym arginyl trna protein transferas ate arginyl play essenti role varieti cellular process includ cell migrat apoptosi cytoskelet organ ate associ neuron function neurogenesi neurit growth howev role ate glial develop includ oligodendrocyt ol differenti myelin process central nervous system poor understood present studi reveal peak ate protein express myelin process primari cultur ol post transcript downregul ate reduc number ol process branch complex vitro condit ablat ate ol mice use cyclic nucleotid phosphodiesteras cre promot ate ko mice assess role ate ol function axon myelin vivo immunostain ol differenti marker reveal notabl reduct matur ol corpus callosum day old ate ko chang spinal cord comparison wild type control local prolifer ol precursor cell elev corpus callosum day old ate ko unchang spinal cord five month old ate ko display reduct matur ol number myelin thick alter motor behavior find taken togeth demonstr ate help maintain proper ol differenti myelin corpus callosum vivo protein arginyl play essenti role development myelin | D055495;D009836 | T040;T025 |
34,669,232 | crispr bet base edit design tool generat stop codon cytosin base editor cbes instal predefin stop codon target site repres predict neater method creat genet knockout without alter genom size due enhanc predict edit outcom also effici obtain homozyg mutant first generat recent advanc cbes improv edit activ purifi specif plant anim base edit becom appeal technolog generat knockout howev lack design tool aid adopt cbes achiev purpos especi plant develop user friend design tool name crispr bet base edit stop help guid rna grna design introduc stop codon protein code gene interest demonstr rice tomato crispr bet easi use generat grnas high specif effici generat stop codon obtain homozyg knockout line tailor tool plant research communiti crispr bet also serv non plant speci | D064112;D000072669 | T028;T114;T063 |
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