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https://en.wikipedia.org/wiki/Prenyltransferase | Prenyltransferases (PTs) are a class of enzymes that transfer allylic prenyl groups to acceptor molecules. Prenyl transferases commonly refer to isoprenyl diphosphate syntheses (IPPSs). Prenyltransferases are a functional category and include several enzyme groups that are evolutionarily independent.
Prenyltransferases are commonly divided into two classes, cis (or Z) and trans (or E), depending upon the stereochemistry of the resulting products. Examples of trans-prenyltranferases include dimethylallyltranstransferase, and geranylgeranyl pyrophosphate synthase. Cis-prenyltransferases include dehydrodolichol diphosphate synthase (involved in the production of a precursor to dolichol). Trans- and cis-prenyltransferases are evolutionarily unrelated to each other and there is no sequential and structural similarity.
The beta subunit of the farnesyltransferases is responsible for peptide binding. Squalene-hopene cyclase is a bacterial enzyme that catalyzes the cyclization of squalene into hopene, a key step in hopanoid (triterpenoid) metabolism. Lanosterol synthase () (oxidosqualene-lanosterol cyclase) catalyzes the cyclization of (S)-2,3-epoxysqualene to lanosterol, the initial precursor of cholesterol, steroid hormones and vitamin D in vertebrates and of ergosterol in fungi. Cycloartenol synthase () (2,3-epoxysqualene-cycloartenol cyclase) is a plant enzyme that catalyzes the cyclization of (S)-2,3-epoxysqualene to cycloartenol.
Human proteins containing this domain
FNTB; |
https://en.wikipedia.org/wiki/Denise%20Sheer | Denise Sheer was appointed professor of human genetics at The Institute of Cell and Molecular Science at Queen Mary, University of London in November 2006. Her fields of expertise include cell and molecular biology; cancer genetics and epigenetics; and molecular pathology of paediatric brain tumours.
Education and career
Sheer completed a BSc (Hons) degree in embryology and zoology at the University of the Witwatersrand, Johannesburg in 1973, after which she ran the diagnostic cytogenetics laboratory at the South African Institute of Medical Research for two years.
She then moved to the genetics laboratory of the University of Oxford, where she was awarded a D.Phil. in 1980. She completed a post-doctoral research fellowship at the Imperial Cancer Research Fund (now the Cancer Research UK London Research Institute) and became head of the Human Cytogenetics Laboratory from 1983 to 2006. Here her work involved the identification of significant genetic aberrations in many malignant cancers and she made critical discoveries on chromosome architecture.
In 2006 she moved with her research group to the Blizard Institute in the Centre for Genomics and Child Health at Barts and The London, Queen Mary's School of Medicine and Dentistry.
Her current research is an interventional clinical trial studying the treatment of young patients with recurrent or refractory low grade glioma, due for completion in 2020. The group received the Jeremy Jass Prize for Excellence in Pathology for th |
https://en.wikipedia.org/wiki/Speedway%20World%20Championship%20Classification | The table below is a classified table of every speedway rider to have finished in the top three of a Speedway World Championship competition.
Classification
Riders
Countries
See also
Motorcycle speedway
References
!
!
pl:Medaliści indywidualnych mistrzostw świata na żużlu#Klasyfikacja medalowa |
https://en.wikipedia.org/wiki/FMS-like%20tyrosine%20kinase%203%20ligand | Fms-related tyrosine kinase 3 ligand (FLT3LG) is a protein which in humans is encoded by the FLT3LG gene.
Flt3 ligand (FL) is a hematopoietic four helical bundle cytokine. It is structurally homologous to stem cell factor (SCF) and colony stimulating factor 1 (CSF-1). In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors. For example, it is a major growth factor stimulating the growth of dendritic cells.
FLT3L functions as a cytokine and growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) by activating the hematopoietic progenitors. It acts by binding to and activating FLT3 (CD135) which is found on what (in mice) are called multipotent progenitor (MPP) and common lymphoid progenitor (CLP) cells. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells.
FLT3L is crucial for steady-state plasmacytoid dendritic cell (pDC) and classical dendritic cell (cDC) development. A lack of FLT3L results in low levels of dendritic cells.
In parasite clearance
FLT3L and its receptor are involved in the mammalian immune response to malaria. In strains of plasmodium, FLT3L was shown to be released from mast cells and cause the expansion of dendritic cells, leading to the activation of CD8+ T cells. The same paper suggested that FLT3L release was caused by stimulation of mast cells with uric ac |
https://en.wikipedia.org/wiki/A%20K%20Peters | A K Peters, Ltd. was a publisher of scientific and technical books, specializing in mathematics and in computer graphics, robotics, and other fields of computer science. They published the journals Experimental Mathematics and the Journal of Graphics Tools, as well as mathematics books geared to children.
Background
Klaus Peters wrote a doctoral dissertation on complex manifolds at the University of Erlangen in 1962, supervised by Reinhold Remmert. He then joined Springer Verlag, becoming their first specialist mathematics editor. As a Springer director from 1971, he hired Alice Merker for Springer New York: they were married that year, and moved to Heidelberg. Leaving Springer, they founded Birkhäuser Boston in 1979; Birkhäuser ran into financial difficulties, and was taken over by Springer. Klaus and Alice then spent a period running a Boston office for Harcourt Brace Jovanovich and their imprint Academic Press. With the takeover of Harcourt Brace Jovanovich by General Cinema Corporation, the couple then found funding from Elwyn Berlekamp to start their own company.
Company history
The company was founded in November 1992 by Alice and Klaus Peters, and maintained as a privately held corporation by the Peters. In 2006 William Randolph Hearst III and David Mumford joined the board. According to Robert J. Lang, who published with them a book on origami and mathematics, A K Peters "was a business, but first and foremost [Klaus] really wanted to create books that were works of |
https://en.wikipedia.org/wiki/Fan%20Ye%20%28historian%29 | Fan Ye (398 – 23 January 446), courtesy name Weizong (蔚宗), was a Chinese historian and politician of the Liu Song dynasty during the Southern and Northern dynasties period. He was the compiler of the historical text Book of the Later Han. The fourth son of Fan Tai (范泰), Fan Ye was born in present-day Shaoxing, Zhejiang, but his ancestral home was in Nanyang, Henan.
He was a noted atheist who heavily criticised Buddhism, Yin and Yang, and the concept of the Mandate of Heaven. To this end, he cited Zhang Heng's scientific studies as evidence.
Fan has a biography in the Book of Song (volume 69).
References
Sources
Tan, Jiajian, "Hou Hanshu" ("Book of Later Han"). Encyclopedia of China (Chinese Literature Edition), 1st ed.
Further reading
Yap, Joseph P. (2019). The Western Regions, Xiongnu and Han, from the Shiji, Hanshu and Hou Hanshu. .
398 births
445 deaths
5th-century executions
5th-century Chinese historians
Executed Liu Song people
Executed Northern and Southern dynasties people
Historians from Zhejiang
Jin dynasty (266–420) historians
Liu Song historians
Liu Song government officials
People executed by a Northern and Southern dynasties state by decapitation
People executed by Liu Song
Writers from Shaoxing
5th-century Chinese philosophers |
https://en.wikipedia.org/wiki/Fan%20Ye | Fan Ye may refer to:
Fan Ye (Han Dynasty), Eastern Han Dynasty official
Fan Ye (historian) (398–445), Liu Song Dynasty historian and politician, compiler of Book of the Later Han
Fan Ye (gymnast) (born 1986), former Chinese gymnast
Fan Ye (translator) (born 1977), Chinese translator
Nickname for Fan Bingbing |
https://en.wikipedia.org/wiki/Neural%20cryptography | Neural cryptography is a branch of cryptography dedicated to analyzing the application of stochastic algorithms, especially artificial neural network algorithms, for use in encryption and cryptanalysis.
Definition
Artificial neural networks are well known for their ability to selectively explore the solution space of a given problem. This feature finds a natural niche of application in the field of cryptanalysis. At the same time, neural networks offer a new approach to attack ciphering algorithms based on the principle that any function could be reproduced by a neural network, which is a powerful proven computational tool that can be used to find the inverse-function of any cryptographic algorithm.
The ideas of mutual learning, self learning, and stochastic behavior of neural networks and similar algorithms can be used for different aspects of cryptography, like public-key cryptography, solving the key distribution problem using neural network mutual synchronization, hashing or generation of pseudo-random numbers.
Another idea is the ability of a neural network to separate space in non-linear pieces using "bias". It gives different probabilities of activating the neural network or not. This is very useful in the case of Cryptanalysis.
Two names are used to design the same domain of research: Neuro-Cryptography and Neural Cryptography.
The first work that it is known on this topic can be traced back to 1995 in an IT Master Thesis.
Applications
In 1995, Sebastien Do |
https://en.wikipedia.org/wiki/Transcription%20factor%20II%20B | Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II preinitiation complex (PIC) and aids in stimulating transcription initiation. TFIIB is localised to the nucleus and provides a platform for PIC formation by binding and stabilising the DNA-TBP (TATA-binding protein) complex and by recruiting RNA polymerase II and other transcription factors. It is encoded by the gene, and is homologous to archaeal transcription factor B and analogous to bacterial sigma factors.
Structure
TFIIB is a single 33kDa polypeptide consisting of 316 amino acids. TFIIB is made up of four functional regions: the C-terminal core domain; the B linker; the B reader and the amino terminal zinc ribbon.
TFIIB makes protein-protein interactions with the TATA-binding protein (TBP) subunit of transcription factor IID, and the RPB1 subunit of RNA polymerase II.
TFIIB makes sequence-specific protein-DNA interactions with the B recognition element (BRE), a promoter element flanking the TATA element.
Mechanism of action
There are six steps in the mechanism of TFIIB action in the formation of the PIC and transcription initiation:
RNA polymerase II is recruited to DNA through the TFIIB B core and B ribbon.
RNA polymerase II unwinds DNA, aided by the TFIIB B linker and B reader (open complex formation).
RNA polymerase II selects a transcription start site, aided by the TFIIB B reader.
RNA polymerase II forms the first phosphodiester bond |
https://en.wikipedia.org/wiki/Transcription%20factor%20II%20E | Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.
TFIIE recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. Transcription factor II E is encoded by the GTF2E1 and GTF2E2 genes. TFIIE is thought to be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA.
See also
TFIIH
TFIIB
TFIID
References
External links
Molecular genetics
Proteins
Gene expression
Transcription factors |
https://en.wikipedia.org/wiki/Transcription%20factor%20II%20F | Transcription factor II F (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.
TFIIF is encoded by the , , and genes.
TFIIF binds to RNA polymerase II when the enzyme is already unbound to any other transcription factor, thus preventing it from contacting DNA outside the promoter. Furthermore, TFIIF stabilizes the RNA polymerase II while it's contacting TBP and TFIIB.
See also
TFIIA
TFIIB
TFIID
TFIIE
TFIIH
References
External links
Molecular genetics
Proteins
Gene expression
Transcription factors |
https://en.wikipedia.org/wiki/Direct%20linear%20transformation | Direct linear transformation (DLT) is an algorithm which solves a set of variables from a set of similarity relations:
for
where and are known vectors, denotes equality up to an unknown scalar multiplication, and is a matrix (or linear transformation) which contains the unknowns to be solved.
This type of relation appears frequently in projective geometry. Practical examples include the relation between 3D points in a scene and their projection onto the image plane of a pinhole camera, and homographies.
Introduction
An ordinary system of linear equations
for
can be solved, for example, by rewriting it as a matrix equation where matrices and contain the vectors and in their respective columns. Given that there exists a unique solution, it is given by
Solutions can also be described in the case that the equations are over or under determined.
What makes the direct linear transformation problem distinct from the above standard case is the fact that the left and right sides of the defining equation can differ by an unknown multiplicative factor which is dependent on k. As a consequence, cannot be computed as in the standard case. Instead, the similarity relations are rewritten as proper linear homogeneous equations which then can be solved by a standard method. The combination of rewriting the similarity equations as homogeneous linear equations and solving them by standard methods is referred to as a direct linear transformation algorithm or |
https://en.wikipedia.org/wiki/RNase%20PH | RNase PH is a tRNA nucleotidyltransferase, present in archaea and bacteria, that is involved in tRNA processing. Contrary to hydrolytic enzymes, it is a phosphorolytic enzyme, meaning that it uses inorganic phosphate as a reactant to cleave nucleotide-nucleotide bonds, releasing diphosphate nucleotides. The active structure of the proteins is a homohexameric complex, consisting of three ribonuclease (RNase) PH dimers. RNase PH has homologues in many other organisms, which are referred to as RNase PH-like proteins. The part of another larger protein with a domain that is very similar to RNase PH is called an RNase PH domain (RPD).
See also
Two highly related exoribonuclease complexes:
Polynucleotide phosphorylase
Exosome complex
References
External links
Crystal structure of Aquifex aeolicus RNase PH at the RCSB Protein Data Bank
Ribonucleases
EC 2.7.7 |
https://en.wikipedia.org/wiki/Gold%28III%29%20oxide | Gold(III) oxide (Au2O3) is an inorganic compound of gold and oxygen with the formula Au2O3. It is a red-brown solid that decomposes at 298 °C.
According to X-ray crystallography, AuO features square planar gold centers with both 2- and 3-coordinated oxides. The four Au-O bond distances range from 193 to 207 picometers. The crystals can be prepared by heating amorphous hydrated gold(III) oxide with perchloric acid and an alkali metal perchlorate in a sealed quartz tube at a temperature of around 250 °C and a pressure of around 30 MPa.
References
External links
Gold(III) compounds
Sesquioxides
Transition metal oxides
Crystals in space group 43 |
https://en.wikipedia.org/wiki/RNase%20R | RNase R, or Ribonuclease R, is a 3'-->5' exoribonuclease, which belongs to the RNase II superfamily, a group of enzymes that hydrolyze RNA in the 3' - 5' direction. RNase R has been shown to be involved in selective mRNA degradation, particularly of non stop mRNAs in bacteria. RNase R has homologues in many other organisms.
When a part of another larger protein has a domain that is very similar to RNase R, this is called an RNase R domain.
Role in trans-translation and ribosomal quality control
RNase R ensures translation accuracy, correct rRNA maturation and elimination of abnormal rRNAs, and is employed by the trans-translation system to break down damaged mRNAs.
In Escherichia coli, RNase R is a 92 kD protein, with the characteristic capacity to degrade structured RNA substrates without displaying sequence specificity. Therefore, RNase R acts over a range of substrates, such as, ribosomal, transfer, messenger and small non-coding RNAs. RNase R is associated with ribonucleoprotein complex that contains tmRNA and SmpB, and is involved in the development of tmRNA under cold-shock.
RNase R is also associated with ribosomes and participates in rRNA, or ribosomal RNA, quality control processes. RNase R has an in vitro affinity for rRNA. In several rRNA quality control pathways, RNase R behaves as a mainfactor by enhancing the removal of faulty rRNA molecules. This protein is also critical for handling rRNA precursors and for observing the ribosome integrity.
RNA digestion |
https://en.wikipedia.org/wiki/RNase%20D | RNase D is one of the seven exoribonucleases identified in E. coli. It is a 3'-5' exoribonuclease which has been shown to be involved in the 3' processing of various stable RNA molecules. RNase D has homologues in many other organisms. When a part of another larger protein has a domain that is very similar to RNase D, this is called an RNase D domain.
References
External links
Crystal structure of E. coli RNase D at the RCSB Protein Data Bank
Ribonucleases
EC 3.1.13 |
https://en.wikipedia.org/wiki/WCR%20FM | 101.8 WCR FM is a community radio station that broadcasts to the city of Wolverhampton, England, on the VHF frequency of 101.8 under an Ofcom - Community Radio licence, at 6:00 a.m. on 30 March 2007 originally from studios in the Newhampton Arts Centre. WCR FM aims to be a vibrant, informative and hyperlocal station providing the city with an alternative service with a mix of speech, specialist and niche programming. The station's licence states it must broadcast a speech content of no less than 30% of its total output and this is achieved primarily by a weekday lunchtime magazine show and a heavier, local news/current affairs series with the station's Community Director, Chris Allen. Other programmes offer additional speech content to cover the requirement.
It operates from a purpose developed three-studio broadcast, production and training complex on the second floor of the Mander Centre following a move from their launch studios at Newhampton Arts Centre in April 2022.
Programme content is primarily produced in-house with a degree of syndicated programming from external sources. Wolverhampton has a mixed-race population of approximately 260,000 and although primarily an English-language station, WCR FM also offers a broadcasting platform for various ethnic and community groups.
Notable presenters
Les Ross
History
WCR FM is related to Wolverhampton Campus Radio, WCR AM, which broadcast to the Wulfrun campus of Wolverhampton College.
Ofcom Breaches
In March 2023, WCR F |
https://en.wikipedia.org/wiki/Scientific%20Vector%20Language | SVL or Scientific Vector Language is a programming language created by Chemical Computing Group. It was first released in 1994. SVL is the built-in command, scripting and application development language of MOE. It is a "chemistry aware" computer programming language with over 1,000 specific functions for analyzing and manipulating chemical structures and related molecular objects. SVL is a concise, high-level language whose programs are typically 10 times smaller than their equivalent when compared to C or Fortran. SVL source code is compiled to a "byte code" representation, which is then executed by the base run-time environment making SVL programs inherently portable across different computer hardware and operating systems.
References
External links
Programming with SVL Vectors
Chemical Computing Group SVL Exchange
Overview of SVL from Scientific Computing World
Programming languages
Research support companies
Software companies of Canada
Software companies established in 1994
Canadian companies established in 1994 |
https://en.wikipedia.org/wiki/Tandem%20mass%20tag | A tandem mass tag (TMT) is a chemical label that facilitates sample multiplexing in mass spectrometry (MS)-based quantification and identification of biological macromolecules such as proteins, peptides and nucleic acids. TMT belongs to a family of reagents referred to as isobaric mass tags which are a set of molecules with the same mass, but yield reporter ions of differing mass after fragmentation. The relative ratio of the measured reporter ions represents the relative abundance of the tagged molecule, although ion suppression has a detrimental effect on accuracy. Despite these complications, TMT-based proteomics has been shown to afford higher precision than Label-free quantification. In addition to aiding in protein quantification, TMT tags can also increase the detection sensitivity of certain highly hydrophilic analytes, such as phosphopeptides, in RPLC-MS analyses.
Versions
There are currently six varieties of TMT available: TMTzero, a non-isotopically substituted core structure; TMTduplex, an isobaric pair of mass tags with a single isotopic substitution; TMTsixplex, an isobaric set of six mass tags with five isotopic substitutions; TMT 10-plex – a set of 10 isotopic mass tags which use the TMTsixplex reporter region, but use different elemental isotope to create a mass difference of 0.0063 Da, TMTpro a 16 plex version with a different reporter and mass normalizer than the original TMT, and TMTpro Zero.
The tags contain four regions, namely a mass reporter region |
https://en.wikipedia.org/wiki/Lake%20lamprey | The lake lamprey, Entosphenus macrostomus, also known as the Vancouver lamprey or Cowichan lamprey, a recent derivative of the Pacific lamprey, is a species of freshwater lamprey endemic to two North American lakes: Lake Cowichan and Mesachie Lake in Vancouver Island, Canada. The lamprey was originally called the Vancouver Island lamprey, until an error in filing shortened it to the Vancouver lamprey. The alternate common name of "Cowichan lamprey" was coined and promoted by the species' describer, Dr. Dick Beamish, who originally identified the species in the 1980s.
Description
An adult lake lamprey is dark blue or dark brown with a lighter belly, and the body is 11.8-27.3 cm in length. The lamprey's disc-like mouth is filled with sharp teeth. The Vancouver lamprey has eyes on the top of its head, two dorsal fins, a caudal fin, and an anal fin.
Distribution and habitat
The lake lamprey is found only in the Cowichan and Mesachie Lakes on Vancouver Island, and is not migratory. The lamprey lives and spawns in shallow gravel areas and typically remains in the lake rather than venturing up streams. The ammocoetes larvae are found in silt depositions along the shores of both lakes. They have been found to be capable of surviving in saltwater through experimentation, but remain in fresh water in the wild. An estimated 1,000 to 2,000 live in the entirety of the two lakes as adults.
Diet
The adults of several lamprey species, including those of the lake lamprey, are hematopha |
https://en.wikipedia.org/wiki/Brochet%20MB.80 | The Brochet MB.80 was a two-seat light aircraft developed in France in the early 1950s.
Design and development
The MB.80 was a derivative of the Brochet MB.70, using essentially the same airframe, but with a redesigned wider fuselage and revised undercarriage. The Service de l'Aviation Légère et Sportive purchased ten examples for distribution to French aeroclubs. Most examples were operated in France, but one example was later sold privately to the United Kingdom.
Variants
MB.80production version powered by Minié 4DC-32B (10 built)
MB.81version with Hirth HM 500B-2 engine (1 built)
MB.83version with Continental C90 engine (1 converted from MB.80)
MB.84version with Continental A65 engine (1 converted from MB.80 F-BGLI)
Specifications (MB.80)
See also
References
1950s French sport aircraft
Brochet aircraft
High-wing aircraft
Single-engined tractor aircraft
Aircraft first flown in 1951 |
https://en.wikipedia.org/wiki/Brochet%20MB.100 | The Brochet MB.100 was a three-seat light aircraft developed in France in the early 1950s.
Design and development
A further derivative of the Brochet MB.70, the MB.100 uses essentially the same airframe as the MB.80, but with a revised tail and cabin, the latter now including a third seat. Service de l'Aviation Légère et Sportive purchased several examples for distribution to French aeroclubs, including a number of tropicalised versions for use in North Africa. Unlike its predecessors, the MB.100 was not designed for homebuilding.
Variants
MB.100 - initial production version (7 built)
MB.101 - tropicalised version with engine air filter and more durable exterior finish (14 built)
Specifications (MB.100)
References
1950s French sport aircraft
Brochet aircraft
High-wing aircraft
Single-engined tractor aircraft
Aircraft first flown in 1951 |
https://en.wikipedia.org/wiki/Erd%C5%91s%E2%80%93Anning%20theorem | The Erdős–Anning theorem states that an infinite number of points in the plane can have mutual integer distances only if all the points lie on a straight line. It is named after Paul Erdős and Norman H. Anning, who published a proof of it in 1945.
Rationality versus integrality
Although there can be no infinite non-collinear set of points with integer distances, there are infinite non-collinear sets of points whose distances are rational numbers. For instance, the subset of points on a unit circle obtained by repeatedly rotating by the sharp angle in a 3–4–5 right triangle has this property. It forms a dense set in the circle. The (still unsolved) Erdős–Ulam problem asks whether there can exist a set of points at rational distances from each other that forms a dense set for the whole Euclidean plane. According to Erdős, Stanisław Ulam was inspired to ask this question after hearing from Erdős about the Erdős–Anning theorem.
For any finite set S of points at rational distances from each other, it is possible to find a similar set of points at integer distances from each other, by expanding S by a factor of the least common denominator of the distances in S. By expanding in this way a finite subset of the unit circle construction, one can construct arbitrarily large finite sets of non-collinear points with integer distances from each other. However, including more points into S may cause the expansion factor to increase, so this construction does not allow infinite sets of p |
https://en.wikipedia.org/wiki/Lake%20Connewarre%20State%20Wildlife%20Reserve | Lake Connewarre State Wildlife Reserve (LCSWR) is a 3411.1 ha Park in Victoria, Australia, that contains a diverse range of unique and significant ecosystems including a river, tidal delta, lakes, swamps, salt marshes and grasslands.
Description
Lake Connewarre State Wildlife Reserve is situated on the lower reaches of the Barwon River on Victoria's Bellarine Peninsula, approximately 8 km south-east of Geelong and 65 km south-west of Melbourne. The Reserve holds the largest area of remnant vegetation on the Bellarine Peninsula and contains the most extensive example of Wilsonia herblands and Distichlis grasslands in Australia. As well as the saline and tidally affected Lake Connewarre itself, the reserve includes the adjacent freshwater Reedy Lake and the ephemeral Murtnaghurt Lagoon. Part of LCSWR is designated a State Game Reserve and is available for duck and quail hunting each year. Other recreational uses include fishing, windsurfing, canoeing and nature study.
Campbell Point protrudes into Lake Connewarre and contains the oldest dated Aboriginal archaeological remains on the Bellarine Peninsula. The deposits have been dated at between 3600 and 5200 years old and are considered significant for their demonstration of shellfish gathering which was uncommon on the central coast of Victoria.
Environment
It is home to over 150 bird species. Several migratory species are listed the under international agreements Japan Australia Migratory Bird Agreement and the China Aus |
https://en.wikipedia.org/wiki/Futures%20Industry%20Association | The Futures Industry Association (FIA) is a prominent global trade organization that represents the interests of the futures, options, and derivatives markets, including futures commission merchants and principal traders. Founded in 1955, the FIA has played a crucial role in shaping the futures industry, advocating for market participants, and fostering the growth of these markets worldwide. With a diverse membership comprising exchanges, clearinghouses, trading firms, banks, and other industry stakeholders, the FIA acts as a unified voice for the futures industry.
Walt Lukken is the president and CEO of the FIA, having succeeded John Damgard in 2012.
Mission and Objectives
The primary mission of the Futures Industry Association is to promote open, transparent, and competitive futures and derivatives markets. The association is committed to advancing the interests of its members and the broader financial community by advocating for sound policies, market integrity, and regulatory reforms. Key objectives of the FIA include:
Advocacy and Policy Development: The FIA engages with regulatory authorities, policymakers, and lawmakers on a global scale to provide expertise and insights into the futures and derivatives markets. It actively participates in the formulation of regulations and policies that impact the industry, ensuring that the interests of market participants are well-represented.
Market Integrity and Standardization: The association places significant emphasis on m |
https://en.wikipedia.org/wiki/Erd%C5%91s%E2%80%93Diophantine%20graph | An Erdős–Diophantine graph is an object in the mathematical subject of Diophantine equations consisting of a set of integer points at integer distances in the plane that cannot be extended by any additional points. Equivalently, in geometric graph theory, it can be described as a complete graph with vertices located on the integer square grid such that all mutual distances between the vertices are integers, while all other grid points have a non-integer distance to at least one vertex.
Erdős–Diophantine graphs are named after Paul Erdős and Diophantus of Alexandria. They form a subset of the set of Diophantine figures, which are defined as complete graphs in the Diophantine plane for which the length of all edges are integers (unit distance graphs). Thus, Erdős–Diophantine graphs are exactly the Diophantine figures that cannot be extended. The existence of Erdős–Diophantine graphs follows from the Erdős–Anning theorem, according to which infinite Diophantine figures must be collinear in the Diophantine plane. Hence, any process of extending a non-collinear Diophantine figure by adding vertices must eventually reach a figure that can no longer be extended.
Examples
Any set of zero or one point can be trivially extended, and any Diophantine set of two points can be extended by more points on the same line. Therefore, all Diophantine sets with fewer than three nodes can be extended, so Erdős–Diophantine graphs on fewer than three nodes cannot exist.
By numerical search, hav |
https://en.wikipedia.org/wiki/Calciorthid | Calciorthid is the taxonomic classification of soils possessing the following properties:
Yellowish to grey colour. (The overall grey colour reflects the deficiency of organic matter)
Poor in nitrogen, phosphorus and potash
Is alkaline, with pH ranging from 7.8 to 8.5.
Are sandy loam to silt in mixture
References
Pedology
Types of soil |
https://en.wikipedia.org/wiki/Soft%20Cell%20discography | This is the discography of Soft Cell, a British synthpop duo consisting of Marc Almond and Dave Ball who rose to prominence in the early 1980s. The duo broke up in 1984 after releasing four albums, but reunited in the early 2000s for a series of live dates and released an album of new material in 2002. The group reunited again in 2018 for a final farewell concert, accompanied by a host of musical and video releases, including a career-spanning box set and a single.
Albums
Studio albums
Remix albums
Live albums
Compilation albums
Charting compilations
Complete list
1982 – The Twelve Inch Singles (Some Bizzare) (6x12" vinyl boxset with booklet)
1986 – The Singles (Some Bizzare)
1991 – Memorabilia – The Singles (Mercury) (Soft Cell with Marc Almond)
1994 – Down in the Subway (Spectrum)
1996 – Say Hello to Soft Cell (Spectrum)
1998 – Master Series (Mercury)
2001 – The Twelve Inch Singles (Polygram) (3CD re-release of the 1982 boxset)
2002 – The Very Best of Soft Cell (Universal)
2005 – The Bedsit Tapes (Some Bizzare) (Recorded in 1978–1980)
2006 – Demo Non Stop (Some Bizzare) (Recorded in 1978–1980)
2006 – 20th Century Masters – The Millennium Collection: The Best of Soft Cell (Universal)
2008 – Heat: The Remixes (Mercury) (2CD collection of new remixes)
2017 - Hits & Pieces The Best of Marc Almond and Soft Cell (UMC)
2018 - Keychains & Snowstorms – The Soft Cell Story (10 Disc Box Set) (UMC)
2018 - Keychains & Snowstorms – The Singles (UMC)
Extended plays
Singles
Promot |
https://en.wikipedia.org/wiki/GFAP%20stain | In histology, the GFAP stain is done to determine whether cells contain glial fibrillary acidic protein, a protein found in glial cells.
It is useful for determining whether a tumour is of glial origin.
References
Staining |
https://en.wikipedia.org/wiki/Resplendent%20pygmy%20angelfish | The resplendent pygmy angelfish (Centropyge resplendens) is a species of marine ray-finned fish, a marine angelfish, belonging to the family Pomacanthidae. It is endemic to Ascension Island in the South Atlantic Ocean.
Description
The resplendent pygmy angelfish has a body which is largely deep blue in colour. There is a yellow patch over the snout and yellow along the back and dorsal fin to the yellow caudal fin. The dorsal fin contains 14 spines and 16 rays while the anal fin has 3 spines and 17 rats. This species attains am maximum total length of .
Distribution
The resplendent pygmy angelfish is found in the South Atlantic Ocean where it is endemic to the waters around Ascension Island.
Habitat and biology
The resplendent pygmy angelfish occur at depths between , over rock and rubble substrates. It feeds on algae or detritus. It is a protogynous hermaphrodite, like other members of the genus Centropyge, and the young fish are of indeterminate sex, become female at sexual maturity and if there is no male the dominant female changes sex to become male. This sex change can be reversed, which takes a few weeks.
Systematics
The resplendent pygmy angelfish was first formally described in 1975 by Hugh Roger Lubbock (1951-1981) and Richard D. Sankey. The specific name resplendens means "resplendent", a reference to the beauty of its colour. Some authorities place this species in the subgenus Xiphypops.
Utilisation
The resplendent pygmy angelfish is rare in the aquarium tra |
https://en.wikipedia.org/wiki/Hypoblast | In amniote embryology, the hypoblast is one of two distinct layers arising from the inner cell mass in the mammalian blastocyst, or from the blastodisc in reptiles and birds. The hypoblast gives rise to the yolk sac, which in turn gives rise to the chorion.
The hypoblast is a layer of cells in fish and amniote embryos. The hypoblast helps determine the embryo's body axes, and its migration determines the cell movements that accompany the formation of the primitive streak, and helps to orient the embryo, and create bilateral symmetry.
The other layer of the inner cell mass, the epiblast, differentiates into the three primary germ layers, ectoderm, mesoderm, and endoderm.
Structure
The hypoblast lies beneath the epiblast and consists of small cuboidal cells. The hypoblast in fish (but not in birds and mammals) contains the precursors of both the endoderm and mesoderm. In birds and mammals, it contains precursors to the extraembryonic endoderm of the yolk sac.
In chick embryos, early cleavage forms an area opaca and an area pellucida, and the region between these is called the marginal zone. Area opaca is the blastoderm's peripheral part where the cells remain unseparated from the yolk. It is a white area that transmits light.
Function
Although the hypoblast does not contribute to the embryo, it influences the orientation of the embryo. The hypoblast also inhibits primitive streak formation. The absence of hypoblast results in multiple primitive streaks in chicken embryo |
https://en.wikipedia.org/wiki/Munro%20%28film%29 | Munro is a 1960 Czechoslovak-American animated short film directed by Gene Deitch, written by Jules Feiffer, and produced by William L. Snyder. Munro won an Oscar for Best Animated Short Film in 1961. It was the first short composed outside of the United States to be so honored. The Academy Film Archive preserved Munro in 2004.
Plot
The title character is a rebellious little boy who is accidentally drafted into the United States Army. No matter which adult he tells, "I'm only four", they all fail to notice his age. Eventually, the harshness of army life makes Munro cry, which causes the general to realize that he really is a little boy. He is discharged and becomes a hero...and whenever he misbehaves, Munro is reminded of his stint in the army.
Production
Screenwriter Feiffer, who adapted his own story from his book Passionella and Other Stories, and provided the storyboards, said the tale was a reaction to his time serving in the U.S. Army:
Munro's voice is provided by Gene Deitch's young son Seth Deitch (later a writer and artist in his own right), while Deitch's wife Marie Deitch does the female voices.
References
External links
Munro at Internet Archive
Entire short on Rembrant Films' official YouTube channel
1960 films
1960 animated films
1960s animated short films
1960s American animated films
1960s Czech films
Best Animated Short Academy Award winners
English-language Czech films
Czech animated short films
Films about military personnel
Films about th |
https://en.wikipedia.org/wiki/Carrier%20lifetime | A definition in semiconductor physics, carrier lifetime is defined as the average time it takes for a minority carrier to recombine. The process through which this is done is typically known as minority carrier recombination.
The energy released due to recombination can be either thermal, thereby heating up the semiconductor (thermal recombination or non-radiative recombination, one of the sources of waste heat in semiconductors), or released as photons (optical recombination, used in LEDs and semiconductor lasers). The carrier lifetime can vary significantly depending on the materials and construction of the semiconductor.
Carrier lifetime plays an important role in bipolar transistors and solar cells.
In indirect band gap semiconductors, the carrier lifetime strongly depends on the concentration of recombination centers. Gold atoms act as highly efficient recombination centers, silicon for some high switching speed diodes and transistors is therefore alloyed with a small amount of gold. Many other atoms, e.g. iron or nickel, have similar effect.
Overview
In practical applications, the electronic band structure of a semiconductor is typically found in a non-equilibrium state. Therefore, processes that tend towards thermal equilibrium, namely mechanisms of carrier recombination, always play a role.
Additionally, semiconductors used in devices are very rarely pure semiconductors. Oftentimes, a dopant is used, giving an excess of electrons (in so-called n-type doping) or |
https://en.wikipedia.org/wiki/Tor%20Arne%20Andreassen | Tor Arne Andreassen (born 16 March 1983) is a Norwegian former footballer who played in defence and midfield for Haugesund.
Career statistics
External links
Guardian's Stats Centre
1983 births
Living people
Norwegian men's footballers
FK Haugesund players
Sportspeople from Haugesund
Footballers from Rogaland
SK Vard Haugesund players
Eliteserien players
Men's association football midfielders |
https://en.wikipedia.org/wiki/Volnay | Volnay is the name of two communes in France:
Volnay, Côte-d'Or
Volnay, Sarthe
It may also refer to:
Volnay AOC, a wine classification based on the town of the same name in Côte-d'Or |
https://en.wikipedia.org/wiki/Tipperary%20Midwest%20Community%20Radio | Tipperary Midwest Community Radio is a non-profit, community radio station which broadcasts from St. Michael's Street, Tipperary Town, Ireland. It broadcasts on the frequency 104.8fm and 106.7fm in the Cashel area and can be heard in parts of eight counties in Ireland namely: Tipperary, Limerick, Cork, Waterford, Kilkenny, Carlow, Laois and Offaly.
History
The station originally started life as a pirate station (Tipperary Community Radio - TCR), after which it gained a commercial license running under the name Tipperary Mid-West Radio (Tipp-Mid West Radio, for short). In 2003 the radio was almost shut down when a clause was introduced whereby only one commercial radio license would be granted in County Tipperary, Clonmel's Tipp FM gaining favourship for the licence. After a series of debates and protests including a petition signed by hundreds of listeners, the station was given a community radio (non-profit) licence by the BAI (Broadcasting Authority of Ireland).
Amalgamation with Cashel
The station also has a secondary broadcast studio in "Halla na Féile", Cashel town. This serves to allow people in the Cashel area to present programmes without having to come to Tipperary Town as well as allowing listeners in the Cashel area to hear news and current affairs from their locality. This is done mainly through Friday's "Morning Call" programme which is broadcast from the Cashel studio. However, other music programmes are also presented from the Cashel studio also. Because t |
https://en.wikipedia.org/wiki/Acceptor%20%28semiconductors%29 | In semiconductor physics, an acceptor is a dopant atom that when substituted into a semiconductor lattice forms a p-type region.
When silicon (Si), having four valence electrons, is doped with elements from group III of the periodic table, such as boron (B) and aluminium (Al), both having three valence electrons, a p-type semiconductor is formed. These dopant elements represent trivalent impurities. Other trivalent dopants include indium (In) and gallium (Ga).
When substituting for a silicon atom in the crystal lattice, the three valence electrons of boron form covalent bonds with three of the Si neighbours but the bond with the fourth remains unsatisfied. The initially electro-neutral acceptor becomes negatively charged (ionised). The unsatisfied bond attracts electrons from the neighbouring bonds. At room temperature, an electron from a neighbouring bond can jump to repair the unsatisfied bond thus leaving an electron hole, which is a place where an electron is deficient. The hole, being positively charged, attracts another electron from a neighbouring bond to repair this unsatisfied bond. This chain-like process results in the hole moving around the crystal as a charge carrier. This process can sustain in an electric current useful in electronic circuits.
See also
Donor (semiconductors)
Electron acceptor
Semiconductors
References
Semiconductor properties |
https://en.wikipedia.org/wiki/Donor%20%28semiconductors%29 | In semiconductor physics, a donor is a dopant atom that, when added to a semiconductor, can form a n-type region.
For example, when silicon (Si), having four valence electrons, is to be doped as a n-type semiconductor, elements from group V like phosphorus (P) or arsenic (As) can be used because they have five valence electrons. A dopant with five valence electrons is also called a pentavalent impurity. Other pentavalent dopants are antimony (Sb) and bismuth (Bi).
When substituting a Si atom in the crystal lattice, four of the valence electrons of phosphorus form covalent bonds with the neighbouring Si atoms but the fifth one remains weakly bonded. If that electron is liberated, the initially electro-neutral donor becomes positively charged (ionised). At room temperature, the liberated electron can move around the Si crystal and carry a current, thus acting as a charge carrier.
See also
Acceptor (semiconductors)
Electron donor
References
Semiconductor properties |
https://en.wikipedia.org/wiki/Chirostoma | {{Automatic taxobox
| fossil_range = Pliocene to Present
| image = FMIB 40491 Chirostoma crystallinum Jordan & Snyder, new species Type.jpeg
| image2 = El pescado blanco (cropped).png
| image2_caption = Chirostoma lucius (above)
Chirostoma estor (below)
| taxon = Chirostoma
| display_parents = 3
| authority = Swainson, 1839
| type_species = Atherina humboldtiana
| type_species_authority = Valenciennes 1835
| synonyms = *Atherinichthys Bleeker, 1853
Atherinoides Bleeker, 1853Charalia F. de Buen, 1945Eslopsarum D.S. Jordan & B.W. Evermann, 1896Heterognathus Girard, 1855Lethostole D.S. Jordan & B.W. Evermann, 1896Ocotlanichthys F. de Buen, 1945Otalia F. de Buen, 1945Palmichthys F. de Buen, 1945
| synonyms_ref =
}}Chirostoma is a genus of Neotropical silversides from the Lerma River basin in Mexico, including lakes Chapala and Pátzcuaro. Fish in the genus collectively go by the common name charal/charales in their native range (a name also used for the related Poblana). They are heavily fished, but several of the species have become threatened due to habitat loss (pollution, water extraction and drought), introduced species and overfishing. Three species are considered extinct: C. bartoni (disappeared 2006), C. charari (1957) and C. compressum (1900). Four others have not been recorded recently and may also be extinct.
Appearance and behavior Chirostoma are generally silvery-white, pale gray-brown or dull yellowish in color, and have a long horizontal line on the side of the |
https://en.wikipedia.org/wiki/Capital%20Gold | The Capital Gold radio station started in London in 1988 on Capital Radio's AM frequency, after the Independent Broadcasting Authority had urged stations to end simulcasting (broadcasting the same programmes simultaneously on AM and FM) and threatened to remove one of their frequencies if simulcasting continued. The original DJs on the early incarnation of Capital Gold included Tony Blackburn, Kenny Everett and David Hamilton. The hiring of radio personalities to host networked shows continued to be a feature of the Capital Gold network as it grew.
History
As required by the forthcoming Broadcasting Act, in 1987 the IBA and the Home Office ruled that all ILR stations were to permanently split their AM and FM frequencies (instead of simulcasting the same service) in order to create new local radio stations and improve choice. In 1986 Capital Radio had experimented with split contemporary formats at weekends, but now responded by launching a "golden oldies" station on its AM frequency, 1548 AM Capital Gold. The station launched on 2 July 1988 as a weekend-only service and went full time on 1 November 1988, while on that date Capital on FM became 95.8 Capital FM, a chart contemporary music station. Both stations received brand-new jingle packages from Muff Murfin and TM Productions in Dallas. These were later followed up by new packages from Californian jingle house Who Did That Music (later Groove Addicts) which went on to become well known and essential parts of its music pr |
https://en.wikipedia.org/wiki/Compass%20equivalence%20theorem | In geometry, the compass equivalence theorem is an important statement in compass and straightedge constructions. The tool advocated by Plato in these constructions is a divider or collapsing compass, that is, a compass that "collapses" whenever it is lifted from a page, so that it may not be directly used to transfer distances. The modern compass with its fixable aperture can be used to transfer distances directly and so appears to be a more powerful instrument. However, the compass equivalence theorem states that any construction via a "modern compass" may be attained with a collapsing compass. This can be shown by establishing that with a collapsing compass, given a circle in the plane, it is possible to construct another circle of equal radius, centered at any given point on the plane. This theorem is Proposition II of Book I of Euclid's Elements. The proof of this theorem has had a chequered history.
Construction
The following construction and proof of correctness are given by Euclid in his Elements. Although there appear to be several cases in Euclid's treatment, depending upon choices made when interpreting ambiguous instructions, they all lead to the same conclusion, and so, specific choices are given below.
Given points , , and , construct a circle centered at with radius the length of (that is, equivalent to the solid green circle, but centered at ).
Draw a circle centered at and passing through and vice versa (the red circles). They will intersect at point |
https://en.wikipedia.org/wiki/Daniel%20Tijolo | Daniel Silva dos Santos, also known as Daniel Tijolo (May 30, 1982 - February 10, 2019), was a Brazilian defensive midfielder who played several years in Japan.
Club statistics
Updated to 23 February 2016.
Honours
Paraná State League: 2006
References
External links
Profile at Oita Trinita
Daniel se apresentam no Cruzeiro
Guardian Stats Centre
1982 births
2019 deaths
Brazilian men's footballers
Brazilian expatriate men's footballers
People from Cabo Frio
Associação Desportiva Cabofriense players
Paysandu Sport Club players
Ituano FC players
Cruzeiro Esporte Clube players
Associação Desportiva São Caetano players
Ventforet Kofu players
Nagoya Grampus players
Oita Trinita players
J1 League players
J2 League players
J3 League players
Expatriate men's footballers in Japan
Brazilian expatriate sportspeople in Japan
Men's association football midfielders
Deaths from lung cancer
Deaths from cancer in Rio de Janeiro (state)
Footballers from Rio de Janeiro (state) |
https://en.wikipedia.org/wiki/Brochet%20MB.110 |
The Brochet MB.110 was a four-seat light aircraft developed in France in the early 1950s.
Design and development
A further derivative of the Brochet MB.70 family, generally similar to those aircraft, the MB.110 was a substantially new and enlarged design. Apart from a bigger passenger cabin with one more seat than previous models, the wing and tail were redesigned, and a more powerful engine was fitted. Two examples were built. The prototype aircraft first flew at Chavenay-Villepreux airfield near Paris on 12 March 1956.
Specifications
References
1950s French sport aircraft
Brochet aircraft
High-wing aircraft
Single-engined tractor aircraft
Aircraft first flown in 1956 |
https://en.wikipedia.org/wiki/Value%20function | The value function of an optimization problem gives the value attained by the objective function at a solution, while only depending on the parameters of the problem. In a controlled dynamical system, the value function represents the optimal payoff of the system over the interval [t, t1] when started at the time-t state variable x(t)=x. If the objective function represents some cost that is to be minimized, the value function can be interpreted as the cost to finish the optimal program, and is thus referred to as "cost-to-go function." In an economic context, where the objective function usually represents utility, the value function is conceptually equivalent to the indirect utility function.
In a problem of optimal control, the value function is defined as the supremum of the objective function taken over the set of admissible controls. Given , a typical optimal control problem is to
subject to
with initial state variable . The objective function is to be maximized over all admissible controls , where is a Lebesgue measurable function from to some prescribed arbitrary set in . The value function is then defined as
with , where is the "scrap value". If the optimal pair of control and state trajectories is , then . The function that gives the optimal control based on the current state is called a feedback control policy, or simply a policy function.
Bellman's principle of optimality roughly states that any optimal policy at time , taking the current state as " |
https://en.wikipedia.org/wiki/Brochet%20MB.120 |
The Brochet MB.120 was a two-seat light aircraft developed in France in the 1950s.
Design and development
A derivative of the Brochet MB.70 family, combining the wing of the MB.80 with a modified fuselage of the MB.100 seating two. The design never progressed past a single prototype.
Specifications
References
1950s French sport aircraft
Brochet aircraft
High-wing aircraft
Single-engined tractor aircraft
Aircraft first flown in 1954 |
https://en.wikipedia.org/wiki/Ammonium%20formate | Ammonium formate, NH4HCO2, is the ammonium salt of formic acid. It is a colorless, hygroscopic, crystalline solid.
Reductive amination
Acetone can be transformed into isopropylamine as follows:
CH3C(O)CH3 + 2 HCO2− +NH4 → (CH3)2CHNHCHO + 2 H2O + NH3 + CO2
(CH3)2CHNHCHO + H2O → (CH3)2CHNH2 + HCO2H
Uses
Pure ammonium formate decomposes into formamide and water when heated, and this is its primary use in industry. Formic acid can also be obtained by reacting ammonium formate with a dilute acid, and since ammonium formate is also produced from formic acid, it can serve as a way of storing formic acid.
Ammonium formate can also be used in palladium on carbon (Pd/C) reduction of functional groups. In the presence of Pd/C, ammonium formate decomposes to hydrogen, carbon dioxide, and ammonia. This hydrogen gas is adsorbed onto the surface of the palladium metal, where it can react with various functional groups. For example, alkenes can be reduced to alkanes, formaldehyde to methanol, and nitro compounds to amines. Activated single bonds to heteroatoms can also be replaced by hydrogens (hydrogenolysis).
Ammonium formate can be used for reductive amination of aldehydes and ketones (Leuckart reaction), by the following reaction:
Ammonium formate can be used as a mobile phase additive in high performance liquid chromatography (HPLC), and is suitable for use with liquid chromatography-mass spectrometry (LC/MS). The pKa values of formic acid and the ammonium ion are 3.8 and 9.2, res |
https://en.wikipedia.org/wiki/Burr%20distribution | In probability theory, statistics and econometrics, the Burr Type XII distribution or simply the Burr distribution is a continuous probability distribution for a non-negative random variable. It is also known as the Singh–Maddala distribution and is one of a number of different distributions sometimes called the "generalized log-logistic distribution".
Definitions
Probability density function
The Burr (Type XII) distribution has probability density function:
The parameter scales the underlying variate and is a positive real.
Cumulative distribution function
The cumulative distribution function is:
Applications
It is most commonly used to model household income, see for example: Household income in the U.S. and compare to magenta graph at right.
Random variate generation
Given a random variable drawn from the uniform distribution in the interval , the random variable
has a Burr Type XII distribution with parameters , and . This follows from the inverse cumulative distribution function given above.
Related distributions
When c = 1, the Burr distribution becomes the Pareto Type II (Lomax) distribution.
When k = 1, the Burr distribution is a log-logistic distribution sometimes referred to as the Fisk distribution, a special case of the Champernowne distribution.
The Burr Type XII distribution is a member of a system of continuous distributions introduced by Irving W. Burr (1942), which comprises 12 distributions.
The Dagum distribution, also known as |
https://en.wikipedia.org/wiki/Return%20of%20Crystal%20Karma | Return of Crystal Karma (often abbreviated to R.O.C.K.) is a studio album by former Deep Purple, Black Sabbath and Trapeze vocalist/bassist Glenn Hughes. The album was released 19 of June 2000 on SPV and Nippon records.
History
Return of Crystal Karma is Hughes’ seventh solo studio album, his sixth since 1992. The album has a similar bass driven funk sound to 1999’s The Way It Is, although R.O.C.K. has a slightly more serious tone.
R.O.C.K. was performed by a set band throughout the album, unlike many of Hughes’ previous albums which had featured multiple musicians and guests. Regular guitarist JJ Marsh makes his third appearance on a Glenn Hughes album and co-wrote many of the tracks. The rest of the band is made up of keyboardist Hans Zermüehlen, Hughes’ regular drummer of the period Gary Ferguson and Lol Tolhurst (former member of The Cure) who contributed some electronica parts.
"Gone" was written by Hughes and Tony Iommi of Black Sabbath for their abandoned 1996 album project. At the point of R.O.C.K.’s release Hughes’ considered it unlikely that those sessions would be released due to their prolific bootlegging. However, Iommi decided to release the songs from the sessions (along with "Gone") in 2004 as The 1996 DEP Sessions.
The instrumental track Owed to J is named in reference to the instrumental Owed to G, which featured on the Deep Purple album Come Taste the Band. The "J" in Hughes' track is a reference to Jeff Beck, and the song is very much influenced by the |
https://en.wikipedia.org/wiki/Ren%C3%A9%20Le%20Fort | René Le Fort (30 March 1869 – 30 March 1951) was a French surgeon from Lille known for creating a classification for fractures of the face.
Early life
René Le Fort was born in 1869, in Lille. His father was a physician and his uncle a renowned surgeon, Léon Clément Le Fort.
When he was 19 and a military student, he was awarded first place into the Internat des Hôpitaux de Lille. Two years later, he was the youngest in France to receive an MD.
Career
After earning his medical degree with a treatise titled Topographie cranio-cérébrale avec applications chirurgicales, he served as a medical resident followed by work as a military surgeon for the French army hospital at Val-de-Grâce. In 1899 he began teaching classes at the medical university in Lille. At the outbreak of the First Balkan War (1912), he re-joined the army as a military physician. During World War I he received a commendation for bravery for his actions at the Battle of Dinant. He spent the last two years of the war in Versailles largely dealing with breast cancer and heart disease issues.
In 1919 he worked at the Hôpital des Invalides prior to returning to Lille the following year. Here he became a professor at the surgical department for pediatric surgery and orthopedics. He was also a volunteer at the sanatorium in Zuydcoote, where he researched treatments for bone tuberculosis. In 1936 he was awarded the Prix Laborie and elected president of the Société française de chirurgie et orthopédique. In 1937 he w |
https://en.wikipedia.org/wiki/Anti-actin%20antibodies | Anti-actin antibodies (AAA) are found at increased frequency in certain autoimmune diseases and may be of some diagnostic value.
In coeliac disease, anti-actin antibody levels correlate with the level of intestinal damage.
In autoimmune hepatitis, anti-actin antibody levels correlate with patterns of immune recognition, the pattern of recognition was specific to a small percentage of autoimmune hepatitis type 1 or cryptogenic hepatitis patients.
In gastric cancer anti-actin antibodies were elevated, along with other antibodies in severe disease with poor outcomes.
It has also been found as a paraneoplastic syndrome with myelodysplastic syndrome.
References
Autoantibodies |
https://en.wikipedia.org/wiki/School%20of%20Rock%20%27n%20Roll | "School of Rock 'n Roll" is a song composed by James McClung in 1958 and published by Song Productions, BMI the same year. It was originally recorded by American rockabilly singer Gene Summers and his Rebels, and was first released in February 1958 by Jan Records #11-100. It was flipped with "Straight Skirt" a teen novelty 45 which became the group's first big regional hit.
"School Of Rock 'n Roll" later became widely known as one of the top 100 rock 'n roll records of the era. In the 1970s, at the beginning of the rockabilly revival in Europe, "School Of Rock 'n Roll" was re-discovered by a new legion of rockabilly fans and bands. Since that time it has become a classic dance floor-filler and has renewed Summers' career to the extent of worldwide concert appearances since 1980.
Acclaim
In 2005 "School of Rock 'n Roll" was selected by Bob Solly and Record Collector Magazine as one of the 100 Greatest Rock 'n' Roll Records. "School Of Rock 'n Roll" was also present in the British television series You've Been Framed and was included on the Rhino Records CD box sets Wild, Fast And Out Of Control (1999) and Rockin' Bones (2006). The song has also been featured on "Bob Dylan's Theme Time Radio Hour" (2006) and also appears on the Bob Dylan 4-CD box set Radio Radio issued in 2011.
Cover versions
The song has been covered by many performers, including:
Savage Kalman & Explosion Rockets on their 1979 LP School Of Rock And Roll
Teen Kats on their 1981 LP After School Rock ‘n Roll |
https://en.wikipedia.org/wiki/Stan%20Cliburn | Stanley Gene Cliburn (born December 19, 1956) is an American former professional baseball player and current manager of the Southern Maryland Blue Crabs of the Atlantic League of Professional Baseball. He was previous the manager of the New Britain Bees and the Rochester Red Wings, the Triple-A affiliate of the Minnesota Twins, from 2006 to 2009. Cliburn has also managed in the Arizona Fall League and at other levels in the minor leagues. He is the twin brother of former Major League pitcher Stu Cliburn, who remains a coach in the Twins' farm system. Cliburn was most recently the manager of the New Britain Bees of the Atlantic League, an independent baseball league.
Playing career
Cliburn played one season in the majors with the California Angels in 1980 during which he appeared in 54 games at catcher, but he would play in over 948 minor league games during his fourteen-year playing career.
Coaching career
After his playing career ended Cliburn was hired as a manager for the Pittsburgh Pirates' New York-Penn League team, and he spent the next 12 seasons managing in the Pirates system, the Texas Rangers system, and for the Alexandria Aces of the independent Texas-Louisiana League. From to , Cliburn was the manager of the New Britain Rock Cats, the Double-A affiliate of the Minnesota Twins. His pitching coach at New Britain for those five seasons was his twin brother Stu Cliburn. On October 18, 2005, Stan Cliburn was named as manager of the Rochester Red Wings, the Triple- |
https://en.wikipedia.org/wiki/Piplani | Piplani () is a town in Bhopal, India, in the BHEL township in the city of Bhopal.
Etymology
Piplani is a derivative of Bhopal which is an adjacent village. Piplani houses the BHEL factory and offices. Nearby attractions include the NCC Grounds and the BHEL Cultural Hall.
Points of interest
Restaurants
Indian Coffee House
Balaji Restaurant
Schools
St Theresas Girls High School
Vikram Higher Secondary School
The Piplani has many BHEL Staff Quarters, some of which are now vacant and destroyed. The entire Piplani is divided into 4 Sectors viz A, B, C, D.
There are many beautiful temples like Jain Mandir, Ganesh Temple, Aiyappa Temple, Kalibadi Temple, Gurudwara Guru Nanak Darbar etc. which are area of attraction for locals and outsiders.
Neighbourhoods in Bhopal |
https://en.wikipedia.org/wiki/Norway%20Corporation | Norway Corporation, also called Norway Productions, is a motion picture and television production company established by Gene Roddenberry. Norway Corporation is best known for having been the production company that brought Star Trek: The Original Series to television on the NBC network in association with Desilu Studios, which later became part of Paramount Television.
Origins
Gene Roddenberry decided to become a producer as a direct result of his frustrations with his work as a television writer and the difficulty he faced in adding anything substantial to his stories. The Lieutenant, a 1963-1964 NBC and MGM Television series about the United States Marine Corps that starred Gary Lockwood as Lieutenant William Rice, was the first series he created and produced. Several future cast members of Star Trek first worked with Roddenberry as regular or guest cast members of The Lieutenant.
According to the entry for Norway Corporation on the Audiovisual Identity Database (AVID), Norway was the name of the street Roddenberry lived on when he was growing up.
Star Trek
Roddenberry developed his idea for Star Trek while working on The Lieutenant. Desilu's vice president of production, Herbert F. Solow, purchased the series concept and made a production deal with Roddenberry in April 1964. Roddenberry pitched the show as "Wagon Train in space," even though it owed more to C. S. Forrester's writings about Horatio Hornblower than to any western.
Having squandered money on a series of |
https://en.wikipedia.org/wiki/Building%20the%20Machine | Building the Machine is a studio album by former Deep Purple, Black Sabbath and Trapeze vocalist/ bassist Glenn Hughes. It was his eighth solo studio album and was released in 2001 on SPV, DNA and Nippon Crown records.
History
Building The Machine has a similar feel to Hughes’ previous album, 2000’s Return of Crystal Karma. Many of the songs have a hard rock sound with a funk edge, although the funk aspect is somewhat toned down on this album and the songs are more driven by guitar riffs than bass lines.
This album marks the fourth collaboration between Hughes and longtime guitarist and co-songwriter JJ Marsh. The album also features contributions from Hughes’ regular drummer of the period Gary Ferguson, keyboardists Vince DiCola and John Beasley and guitarist Pat Travers, who duets with Hughes on the Rare Earth cover I Just Want To Celebrate. Bobby Kimball of Toto provides backing vocals on two of the tracks.
The track High Ball Shooter is a newly recorded version of the Deep Purple song, which originally featured on the album Stormbringer.
The Japanese version of the album includes the track Cosmic Spell, which was written by Hughes and Pat Travers.
The opening track Can’t Stop The Flood also kicked off Hughes’ 2004 live album Soulfully Live in the City of Angels and often frequents his set-lists.
Track listing
"Can't Stop the Flood" – 4:11 (Hughes, Marsh)
"Inside" – 4:52 (Hughes, Marsh)
"Out On Me" – 5:32 (Hughes)
"I Just Want To Celebrate" – 3:23 (Fekaris, Zesses)
" |
https://en.wikipedia.org/wiki/Nucleoporin%20210kDa | Nuclear pore glycoprotein-210 (gp210) is an essential trafficking regulator in the eukaryotic nuclear pore complex. Gp-210 anchors the pore complex to the nuclear membrane. and protein tagging reveals its primarily located on the luminal side of double layer membrane at the pore.
A single polypeptide motif of gp210 is responsible for sorting to nuclear membrane, and indicate the carboxyl tail of the protein is oriented toward the cytoplasmic side of the membrane.
Disassembly and Assembly
During eukaryotic mitosis the nuclear envelope disintegrates into vesicles dispersing nuclear lamina proteins and nuclear pore complexes. Nup210 is specifically phosphorylated on the C-terminal (cytoplasmic) domain in mitosis at Ser1880 and is dispersed throughout the endoplasmic reticulum during mitosis as homodimers. Nuclear lamins begin to reassemble around chromosomes at the end of mitosis. Nup210 lags the reassembly process relative to other Nups. and while much of the assembly process can occur without it, the final assembly and dilation of the complexes require Nup210. The replacement of serine at position 1880 with a phosphorylated 'looking' glutamate results in Nup210 complexes that fail to reassemble indicating that dephosphorylation of Nup210 within the final phases of proper assembly is required.
Pathology
Recognized by anti-nuclear antibodies found in primary biliary cirrhosis (PBC) anti-Nup210 antibodies correlate with progression toward end stage liver disease. Nup210 is pos |
https://en.wikipedia.org/wiki/Anti-glycoprotein-210%20antibodies | Anti-glycoprotein-210 antibodies (AGPA, anti-gp210, anti-nup210, anti-np210) are directed at gp210 and are found within primary biliary cirrhosis (PBC) patients in high frequency. AGPA recognize the cytoplasmic-oriented carboxyl terminus (tail) of the protein. While AGPA is found as a prognostic marker in only a minority of PBC patients, those that did had higher mortality and were predicted a poor outcome. In addition, patients that responded to ursodeoxycholic acid (UDCA) therapy and, therefore, had AGPA reductions failed to develop end-stage liver disease relative to untreated cohort with anti-gp210 Ab. PBC patients with potentially destructive
AGPA have increased expression of Nup210 in the bile duct, a potential immune tolerance-escaping factor.
Anti-mitochondrial, anti-centromere and anti-p62 antibodies are also found in (PBC). While patients with AGPA progress toward end-stage liver failure, patients with anti-centromere antibodies often progress toward portal hypertension, further indicating a specific role of the AGPA in PBC.
Notes
The glycoprotein gp210 is commonly used in the literature. The gene, NUP210, encodes the nuclear pore (nuclear porin) glycoprotein-210 that is a major component of the human nuclear pore complex.
References
G
G |
https://en.wikipedia.org/wiki/Mercury%20vapour%20turbine | A mercury vapour turbine is a form of heat engine that uses mercury as the working fluid of its thermal cycle. A mercury vapour turbine has been used in conjunction with a steam turbine for generating electricity. This example of combined cycle generation was not widely adopted, because of high capital cost and the obvious toxic hazard if the mercury leaked into the environment.
The mercury cycle offers an efficiency increase compared to a steam-only cycle because energy can be injected into the Rankine cycle at higher temperature. Metallurgical developments have allowed steam-only plants to increase in efficiency over time, making the mercury vapour turbine obsolete. Modern combined cycle power plant generating stations operate at 61% efficiency, and with none of the safety issues inherent to a binary mercury Rankine cycle steam power plant.
Historical example
The Electrical Year Book, 1937, contained the following description of a mercury vapour turbine operating in commercial use:
The advantage of operating a mercury-vapour turbine in conjunction with a steam power plant lies in the fact that the complete cycle can be worked over a very wide range of temperature without employing any abnormal pressure. The exhaust from the mercury turbine is used to raise steam for the steam turbine. The Hartford Electric Light Co. (U.S.A.) has a 10,000kW turbo-generator driven by mercury vapour, which reaches the turbine at 70 lb. per sq. in. (gauge), 880°F. The mercury vapour is |
https://en.wikipedia.org/wiki/Salomon%20%28surname%29 | Salomon is a surname. It originated as a derivative of the Hebrew biblical name Šlāmā (also transliterated as Šlomo), for which the conventional latinization has been Solomon or Salomon. As a surname, Salomon is common among Jews; it has been documented since the Middle Ages even among non-Jews in Western Europe.
Derivatives may include Salmon, Salman and Salamon. The latter form is particularly common in Hungary, and should not be confused with the Venetian family of the same name.
Notable people with the surname
Anne Salomon, marine ecologist
Albert Salomon (surgeon) (1883–1976), German surgeon
Albert Salomon (1891–1966), German sociologist
Alice Salomon (1872–1948), German social reformer
Ben L. Salomon (1914–1944), Medal of Honor recipient, U.S. Army (Battle of Saipan)
Charles Eberhard Salomon (1824–1881), colonel in the Union Army during the American Civil War
Charlotte Salomon (1917–1943), German-Jewish artist
Daniel Salomon (musician) (born 1973), Israeli pop rock singer and musician
Daniel Salomon (politician) (born 1957), Republican member of the Montana Legislature
Dieter Salomon (born 1960), mayor of Freiburg, Germany
Edward Salomon (1828–1909), governor of Wisconsin
Edward S. Salomon (1836–1913), American Civil War general and governor of the Washington Territory
Emil Salomonsson (born 1989), Swedish international footballer
Erich Salomon (1886–1944), German photographer
Ernst von Salomon (1902–1972), ex-Freikorps member, German writer and one of |
https://en.wikipedia.org/wiki/U4 | U4, U-4, or U04 may refer to:
Science and technology
U4 spliceosomal RNA, a non-coding RNA component of the major U2-dependent spliceosome
Haplogroup U4 (mtDNA), a human genetic group
U4, unitary group of degree 4
U-47700, a synthetic opioid
U04, the ICD-10 code for severe acute respiratory syndrome
Transport
U-Bahn lines
U4 (Berlin U-Bahn)
U4 (Frankfurt U-Bahn)
U4 (Hamburg U-Bahn)
U4 (Munich U-Bahn)
U4 (Vienna U-Bahn)
German submarine U-4, one of several German submarines
London Buses route U4
U-4, the U.S. Air Force version of the Aero Commander (aircraft), a light twin-engined aircraft from Aero Design and Engineering Company
U-4, the Japanese air self-defense force designation for the Gulfstream IV aircraft
U4, PMTair (former) IATA airline designator
U4, Buddha Air current IATA airline designator
Organizations
U4, the former name of the Maple League of Universities
Anti-Corruption Resource Centre, based at the Chr. Michelsen Institute in Bergen, Norway
Other uses
U4, an unemployment figure released by the United States Bureau of Labor Statistics
Ultima IV: Quest of the Avatar, a video game
See also
4U (disambiguation) |
https://en.wikipedia.org/wiki/Philip%20George%20Houthem%20Gell | Philip George Houthem Gell (20 October 1914 – 3 May 2001) was a British immunologist working in postwar Britain.
Together with Robin Coombs, he developed the Gell–Coombs classification of hypersensitivity. He was elected Fellow of the Royal Society in 1969.
References
1914 births
2001 deaths
British immunologists
Fellows of the Royal Society |
https://en.wikipedia.org/wiki/Adaptive%20autonomy | Adaptive autonomy refers to a suggestion for the definition of the notation 'autonomy' in mobile robotics.
Human-automation interaction
The extremist idea of "eliminate the human from the field" rendered the ironies of automation to the extent that the researchers in the related fields shifted the paradigm to the idea of "best-fit autonomy for the computers", to provide more humane automation solutions.
One of the first human-machine function-allocation methods was presented by P. M. Fitts in 1951, which was used in automation systems design. Nevertheless, the function allocation concept remains problematic after half a century, and the basic validity of formal function allocation methods has been challenged repeatedly.
Clarifications
The peripheral situations affect the performance of cybernetic systems; therefore, though one-shot human-centered automation (HCA) designs might provide better results than the systems designed based on the "automate it as possible" philosophy; however, these designs fail to maintain the advantages of the HCA designs, when the peripheral situations change.
Consequently, the automation solutions should be smart enough to adapt the level of automation (LOA) to the changes in peripheral situations. This concept is known as adaptive automation or adjustable autonomy; however, the term "adaptive autonomy" (AA) seems more appropriate to prevent confusion with the phrases like adaptive control and adaptive automation in systems control term |
https://en.wikipedia.org/wiki/Media-embedded%20processor | A media-embedded processor (MeP) is a configurable 32-bit processor design from Toshiba Semiconductor for embedded media processing applications.
References
External links
GCC port to Toshiba MeP
Toshiba brands
Microprocessors |
https://en.wikipedia.org/wiki/Anti-p62%20antibodies | Anti-p62 antibodies (AP62A) are found in a primary biliary cirrhosis. The p62 protein is also more frequent in Stage IV primary biliary cirrhosis and is prognostic for severe disease. The autoantigen is the nucleoporin 62kDA protein.
References
p
P |
https://en.wikipedia.org/wiki/Structural%20estimation | Structural estimation is a technique for estimating deep "structural" parameters of theoretical economic models. The term is inherited from the simultaneous equations model. Structural estimation is extensively using the equations from the economics theory, and in this sense is contrasted with "reduced form estimation" and other nonstructural estimations that study the statistical relationships between the observed variables while utilizing the economics theory very lightly (mostly to distinguish between the exogenous and endogenous variables, so called "descriptive models"). The idea of combining statistical and economic models dates to mid-20th century and work of the Cowles Commission.
The difference between a structural parameter and a reduced-form parameter was formalized in the work of the Cowles Foundation. A structural parameter is also said to be "policy invariant" whereas the value of reduced-form parameter can depend on exogenously determined parameters set by public policy makers. The distinction between structural and reduced-form estimation within "microeconometrics" is related to the Lucas critique of reduced-form macroeconomic policy predictions.
Structured and reduced form models
When the Cowles Commission introduced the term "reduced form" it was used to define a set of equations where the "left-hand" dependent variables never appeared on the right-hand of the equations, as opposed to the simultaneous equations, where the dependent variable of an equatio |
https://en.wikipedia.org/wiki/Dibromotyrosine | Dibromotyrosine is an antithyroid preparation and a derivative of the natural amino acid tyrosine.
It is formed by eosinophil peroxidase.
References
Alpha-Amino acids
Amino acid derivatives
Bromoarenes |
https://en.wikipedia.org/wiki/Lazy%20linear%20hybrid%20automaton | Lazy linear hybrid automata model the discrete time behavior of control systems containing finite-precision sensors and actuators interacting with their environment under bounded inertial delays. The model permits only linear flow constraints but the invariants and guards can be any computable function.
This computational model was proposed by Manindra Agrawal and P. S. Thiagarajan. This model is more realistic and also computationally amenable than the currently popular modeling paradigm of linear hybrid automaton.
External links
Formalization and theory behind the model
Reachability Analysis of Lazy Linear Hybrid Automata Research
Automata (computation)
Models of computation |
https://en.wikipedia.org/wiki/Wet%20Lake%20%28Warmia-Masuria%20Voivodeship%29 | Wet Lake () is a ribbon lake in the Mrągowskie Lakeland of Poland. There are 5 islands in the lake. It is situated in the Mazurski Landscape Park near Zgon.
Statistics
Length: 7.7 km
Width: 1.6 km
Area: 846 ha
Maximum depth: 51 m
Lakes of Poland
Lakes of Warmian-Masurian Voivodeship |
https://en.wikipedia.org/wiki/WBWX | WBWX (1280 AM) is a radio station licensed to the U.S. city of Berwick, Pennsylvania and serves the immediate Berwick/Bloomsburg radio market. The station broadcasts at a frequency of 1280 kHz with 1,000 watts daytime, and 164 watts nighttime with a non-directional signal pattern.
Until 2022, the station was owned by the Columbia Broadcasting Company which also owned WHLM. The station currently simulcasts the programming heard on WHLM and is operated out of studios in Selinsgrove, Pennsylvania.
History
WBWX first signed on the air in 1957 as WBRX, with its license granted to Columbia County Broadcasters, Inc. on November 4, 1957
As WSQV, the station held a contemporary Christian/religious format and eventually went silent under ownership of Heritage Broadcasting, Inc.
The station was purchased by Kevin Fennessy and on April 1, 2000, the station relaunched as "WFBS Radio Smiles", with a format of early 60s music.
WFBS was purchased by Bold Gold Media Group in 2007, and under their ownership, the station aired a simulcast of all-sports network "The Game", which was also heard on WYCK, WICK, and WPSN.
In 2011, WFBS was purchased by the Columbia Broadcasting Company, which owns WHLM in Bloomsburg. The callsign was changed to WBWX (as a nod to the former WBRX), and changed formats to a simulcast of its new sister station WHLM-AM. During high school football season, WBWX will split from its regular simulcast of WHLM-AM and air Berwick football.
On March 21, 2022, the Press E |
https://en.wikipedia.org/wiki/Difference%20in%20the%20depth%20of%20modulation | The difference in the depth of modulation (DDM) is used by instrument landing systems in conjunction with the associated airborne receiving equipment to define a position in airspace. DDM is usually expressed in percentage but may also be expressed in microamperes. The two individual audio modulation frequencies and their associated sidebands are 90 and 150 Hz. The DDM for a localizer at the outer extremity of the course sector is 15.5% or an electric current equivalent of 150 microamperes full scale deflection.
Method
A modulation depth comparison navigational aid (MDCNA), also known as an instrument landing system uses the concept of space modulation to provide guidance to aircraft when on final approach.
A carrier and sideband (CSB), and sideband only (SBO) signal, transmitted from localizer and glide path antennas produce a space-modulated signal resulting from the vectorial addition of two or more audio signals that vary according to position of the receiving aircraft.
The difference between the two modulation depths produce an error current signal in the airborne receiver. When an aircraft follows the course line, the difference in the depths of the modulation between the two frequencies is zero.
This difference is conventionally displayed by the deflection of a moving coil indicator or needle on an instrument known as a horizontal situation indicator (HSI).
See also
Amplitude modulation
International Civil Aviation Organization (ICAO)
Radio navigation
References |
https://en.wikipedia.org/wiki/Nuclear%20pore%20glycoprotein%20p62 | Nuclear pore glycoprotein p62
is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa followed by modification that involve addition of N-acetylglucosamine residues, followed by association with other complex proteins. In humans it is encoded by the NUP62 gene.
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform.
Structure
P62 is a serine/threonine rich protein of ~520 amino acids, with tetrapeptide repeats on the amino terminus and a series of alpha-helical regions with hydrophobic heptad repeats forming beta-propeller domain. P62 assembles into a complex containing 3 addition proteins, p60, p54 and p45 forming the p62 complex of ~235 kDa. O-GlcNAcylation appears to be involved in the assembly and disassembly of p62 into higher order complexes, and a seri |
https://en.wikipedia.org/wiki/Fenyramidol | Fenyramidol (INN) or phenyramidol (BAN, USAN), trade name Cabral, is a pharmaceutical drug which acts as a muscle relaxant.
Drug Interactions
Fenyramidol inhibits the metabolism of phenytoin, leading to possible increases in plasma phenytonin levels.
References
Aminopyridines
Drugs with unknown mechanisms of action
Phenylethanolamines |
https://en.wikipedia.org/wiki/Serum-ascites%20albumin%20gradient | The serum-ascites albumin gradient or gap (SAAG) is a calculation used in medicine to help determine the cause of ascites. The SAAG may be a better discriminant than the older method of classifying ascites fluid as a transudate versus exudate.
The formula is as follows:
SAAG = (serum albumin) − (albumin level of ascitic fluid).
Ideally, the two values should be measured at the same time.
This phenomenon is the result of Starling's forces between the fluid of the circulatory system and ascitic fluid. Under normal circumstances the SAAG is < 1.1 because serum oncotic pressure (pulling fluid back into circulation) is exactly counterbalanced by the serum hydrostatic pressure (which pushes fluid out of the circulatory system). This balance is disturbed in certain diseases (such as the Budd–Chiari syndrome, heart failure, or liver cirrhosis) that increase the hydrostatic pressure in the circulatory system. The increase in hydrostatic pressure causes more fluid to leave the circulation into the peritoneal space (ascites). The SAAG subsequently increases because there is more free fluid leaving the circulation, concentrating the serum albumin. The albumin does not move across membrane spaces easily because it is a large molecule. A rare cause of ascites, with elevated SAAG, and without change in hydrostatic/osmotic pressure is urinary bladder rupture with leakage of urine into the peritoneal space.
Differential
High gradient
A high gradient (> 1.1 g/dL, >11 g/L) indicates the a |
https://en.wikipedia.org/wiki/Digoxin%20immune%20fab | Digoxin immune fab or digoxin-specific antibody is an antidote for overdose of digoxin. It is made from immunoglobulin fragments from sheep that have already been immunized with a digoxin derivative, digoxindicarboxymethoxylamine (DDMA). Its brand names include Digibind (GlaxoSmithKline) and DigiFab (BTG plc).
Medical uses
It is used for digoxin toxicity. Digoxin toxicity can emerge during long-term therapy as well as after an overdose. It can occur even when the serum digoxin concentration is within the therapeutic range when one of the following is present:
Hemodynamically unstable arrhythmia
End organ damage
digoxin level > 4 ng/ml if chronic ingestion
digoxin level > 10 ng/ml if acute ingestion
potassium > 5 mEq/L and symptomatic
Side effects of digoxin immune fab may occur:
hives
difficult breathing
swelling of the lips, tongue, face, or throat
itching
skin redness
wheezing
cough
lightheadedness
Contraindications
Avoid use in hypokalemia as this drug, while reversing the effects of digitalis, will further reduce serum potassium levels and could precipitate dangerous and even fatal cardiac arrhythmias.
The patient must be closely monitored for anaphylactic shock, and anyone allergic to sheep protein, papain, bromelain, or papaya extracts (papain is used to cleave the antibody into Fab and Fc fragments) should not use ovine digoxin immune fab. Because it is relatively new, no drug interaction studies have been performed yet.
Pharmacology
It works by bin |
https://en.wikipedia.org/wiki/LRRTM1 | LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in neurons. As the name implies, its protein product is a transmembrane protein that contains many leucine rich repeats. It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).
Clinical significance
LRRTM1 is the first gene linked to increased odds of being left-handed, when inherited from the father's side. Possessing one particular variant of the LRRTM1 gene slightly raises the risk of psychotic mental illnesses such as schizophrenia, again only if inherited from the father's side. As well, LRRTM1 has been associated with measures of schizotypy in non-clinical populations, indicating that the gene may have shared effects on neurodevelopment in both healthy and unhealthy individuals and individuals with schizophrenia.
LRRTM1 is also critically involved in synapse formation within the dorsal lateral geniculate nucleus (dLGN) of mice. LRRTM1 aids in the assembly of complex retinogenciulate synapses in mice, which are believed to help process complex visual signals. Lack of this gene shows decreased performance in complex visual tasks.
See also
Handedness
References
Further reading
Genes on human chromosome 2
Motor skills |
https://en.wikipedia.org/wiki/Peter%20Eriksson%20%28neuroscientist%29 | Peter Eriksson (June 5, 1959 – August 2, 2007) was a Swedish stem cell neuroscientist.
Eriksson was a frequently cited scientist who conducted ground-breaking research on neurogenesis in the hippocampus of the adult human brain. In 1998 he demonstrated the creation of nerve cells in the adult human hippocampus. He showed that new brain cells are created throughout the whole human lifespan, and that the integration of the new brain cells in the brain depended on the stimuli that the environment offered, thus providing an insight that could enhance the treatment of neurologically damaged patients.
He also elucidated the mechanism for neurogenesis, which could potentially lead to a cure for a range of neurological diseases, including Alzheimer's disease.
References
1959 births
2007 deaths
Swedish neuroscientists
Academic staff of the University of Gothenburg |
https://en.wikipedia.org/wiki/Peter%20Eriksson | Peter Eriksson may refer to:
Peter Eriksson (politician) (born 1958), spokesperson for the Swedish Green Party
Peter Eriksson (neuroscientist) (1959–2007), Swedish stem cell neuroscientist
Peter Eriksson (equestrian) (born 1959), Olympic medallist in equestrian events
Peter Eriksson (ice hockey) (born 1965), retired Swedish professional ice hockey left winger
Peter Eriksson (footballer) (born 1969), Swedish footballer
Peter Eriksson (coach) (born 1952), athletics coach
Peter Eriksson (curler) (born 1964), Swedish curler
Peter Eriksson (sailor) (born 1960), Swedish Olympic sailor
Peter Eriksson (snocross), Swedish Snocross racer, winner of 3 World Championships |
https://en.wikipedia.org/wiki/Mindstorm | Mindstorm or Mindstorms may refer to:
Mindstorm (film), a science-fiction telefilm
Lego Mindstorms, a series of programmable robotics kits
MinDStorm, a 2006 educational video game
Mindstorm Studios, a computer video game developer and software developer company
Mindstorms (book), 1980 book by Seymour Papert
"Mind Storm", a song by Joe Satriani on his album Strange Beautiful Music |
https://en.wikipedia.org/wiki/Sorenson%20Molecular%20Genealogy%20Foundation | The Sorenson Molecular Genealogy Foundation (SMGF) was an independent DNA and genealogical research institution with the goal of demonstrating how the peoples of the world are related. SMGF collected DNA samples and genealogical information from individuals across the globe to establish these connections.
History
SMGF originated in 1999 and was inspired by several conversations between inventor and philanthropist James LeVoy Sorenson and Brigham Young University professor Dr. Scott Woodward. Mr. Sorenson envisioned the development of a genetic-genealogical blueprint of all humankind. This blueprint, as developed by Dr. Woodward, would show how closely humans are related to one another, demonstrating the familial relationships between unique individuals. The collection of DNA samples and associated family pedigrees began in 2000, beginning first with Brigham Young University students, and quickly branching outside of Utah, then to the rest of the world.
In 2003, SMGF moved its operations from the Brigham Young University campus to Salt Lake City. SMGF also outsourced all of its laboratory work to Sorenson Genomics, freeing researchers to create a publicly available online repository. This repository was known as the Sorenson Database.
SMGF collected more than 100,000 DNA samples and familial pedigrees from donors around the world, all of which were available in the Sorenson Database. This database was acquired by Ancestry.com prior to its launch of AncestryDNA when the |
https://en.wikipedia.org/wiki/Calyx%20of%20Held | The Calyx of Held is a particularly large synapse in the mammalian auditory central nervous system, so named after Hans Held who first described it in his 1893 article Die centrale Gehörleitung because of its resemblance to the calyx of a flower. Globular bushy cells in the anteroventral cochlear nucleus (AVCN) send axons to the contralateral medial nucleus of the trapezoid body (MNTB), where they synapse via these calyces on MNTB principal cells. These principal cells then project to the ipsilateral lateral superior olive (LSO), where they inhibit postsynaptic neurons and provide a basis for interaural level detection (ILD), required for high frequency sound localization. This synapse has been described as the largest in the brain.
The related endbulb of Held is also a large axon terminal smaller synapse (15-30 μm in diameter) found in other auditory brainstem structures, namely the cochlear nucleus. As with the calyces, these synapses promote fast, efficient information transfer.
The calyx of Held holds vesicles containing glutamate on the presynaptic terminal, the vesicles are released upon stimulation (originating in the auditory system). The glutamate then binds to two known glutamate receptors, AMPA- and NMDA receptors.
Commonly used in research due to its large size, the calyx of Held has been used to understand a variety of mechanisms related to development of, and vesicle release of the synapse.
Function
The calyx of Held is a part of the auditory system, connect |
https://en.wikipedia.org/wiki/Neutral%20vector | In statistics, and specifically in the study of the Dirichlet distribution, a neutral vector of random variables is one that exhibits a particular type of statistical independence amongst its elements. In particular, when elements of the random vector must add up to certain sum, then an element in the vector is neutral with respect to the others if the distribution of the vector created by expressing the remaining elements as proportions of their total is independent of the element that was omitted.
Definition
A single element of a random vector is neutral if the relative proportions of all the other elements are independent of .
Formally, consider the vector of random variables
where
The values are interpreted as lengths whose sum is unity. In a variety of contexts, it is often desirable to eliminate a proportion, say , and consider the distribution of the remaining intervals within the remaining length. The first element of , viz is defined as neutral if is statistically independent of the vector
Variable is neutral if is independent of the remaining interval: that is, being independent of
Thus , viewed as the first element of , is neutral.
In general, variable is neutral if is independent of
Complete neutrality
A vector for which each element is neutral is completely neutral.
If is drawn from a Dirichlet distribution, then is completely neutral. In 1980, James and Mosimann showed that the Dirichlet distribution is characterised by neutrality. |
https://en.wikipedia.org/wiki/Generalized%20Dirichlet%20distribution | In statistics, the generalized Dirichlet distribution (GD) is a generalization of the Dirichlet distribution with a more general covariance structure and almost twice the number of parameters. Random vectors with a GD distribution are completely neutral.
The density function of is
where we define . Here denotes the Beta function. This reduces to the standard Dirichlet distribution if for ( is arbitrary).
For example, if k=4, then the density function of is
where and .
Connor and Mosimann define the PDF as they did for the following reason. Define random variables with . Then have the generalized Dirichlet distribution as parametrized above, if the are independent beta with parameters , .
Alternative form given by Wong
Wong gives the slightly more concise form for
where for and . Note that Wong defines a distribution over a dimensional space (implicitly defining ) while Connor and Mosiman use a dimensional space with .
General moment function
If , then
where for and . Thus
Reduction to standard Dirichlet distribution
As stated above, if for then the distribution reduces to a standard Dirichlet. This condition is different from the usual case, in which setting the additional parameters of the generalized distribution to zero results in the original distribution. However, in the case of the GDD, this results in a very complicated density function.
Bayesian analysis
Suppose is generalized Dirichlet, and that is multinomial with trials |
https://en.wikipedia.org/wiki/Collagen%2C%20type%20I%2C%20alpha%202 | Collagen alpha-2(I) chain is a protein that in humans is encoded by the COL1A2 gene.
This gene encodes one of the chains for type I collagen, the fibrillar collagen found in most connective tissues. Mutations in this gene are associated with osteogenesis imperfecta, Cardiac-valvular, and Arthrochlasia type Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for alpha-1 type I collagen, since alpha-2 is less abundant. Multiple messages for this gene result from multiple polyadenylation signals, a feature shared by most of the other collagen genes.
See also
Type-I collagen
Collagen
References
Further reading
External links
GeneReviews/NCBI/NIH/UW entry on Osteogenesis Imperfecta
Collagens |
https://en.wikipedia.org/wiki/Bulinus%20crystallinus | Bulinus crystallinus is a species of small air-breathing freshwater snail with a sinistral shell, an aquatic pulmonate gastropod mollusk in the family Bulinidae, the ramshorn snails and their allies.
Distribution
This species is found in Angola and Gabon.
References
Morelet, A., 1868 Mollusques terrestres et fluviatiles. In: Voyage du Dr. Friederich Welwitsch exécuté par ordre du gourvernement portugais dans les royaumes d'Angola et de Benguela, p. 102 pp
Breure, A. S. H., Audibert, C., Ablett, J. D. (2018). Pierre Marie Arthur Morelet (1809-1892) and his contributions to malacology. Leiden: Nederlandse Malacologische Vereniging. 544 pp.
Bulinus
Gastropods described in 1868
Taxonomy articles created by Polbot |
https://en.wikipedia.org/wiki/Beta-synuclein | Beta-synuclein is a protein that in humans is encoded by the SNCB gene.
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer's disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson's disease; however, no direct relation to Parkinson's disease has been established. Two transcript variants encoding the same protein have been found for this gene.
Beta-synuclein is a synuclein protein found primarily in brain tissue and is seen mainly in presynaptic terminals. Beta-synuclein is predominantly expressed in the neocortex, hippocampus, striatum, thalamus, and cerebellum. It is not found in Lewy bodies, but it is associated with hippocampal pathology in PD and DLB.
Beta-synuclein is suggested to be an inhibitor of alpha-synuclein aggregation, which occurs in neurodegenerative diseases such as Parkinson's disease. Thus, beta-synuclein may protect the central nervous system from the neurotoxic effects of alpha-synuclein and provide a novel treatment of neurodegenerative disorders.
See also
Synuclein
References
Further reading
External links |
https://en.wikipedia.org/wiki/Gamma-synuclein | Gamma-synuclein is a protein that in humans is encoded by the SNCG gene.
Synuclein-gamma is a member of the synuclein family of proteins, which are believed to be involved in the pathogenesis of neurodegenerative diseases. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.
Gamma-synuclein is a synuclein protein found primarily in the peripheral nervous system (in primary sensory neurons, sympathetic neurons, and motor neurons) and retina. It is also detected in the brain, ovarian tumors, and in the olfactory epithelium. Gamma-synuclein is the least conserved of the synuclein proteins.
Gamma-Synucleins expression in breast tumors is a marker for tumor progression as mammalian gamma-synuclein was first identified as breast cancer-specific gene 1 (BCSG1). A change in the expression of gamma-synuclein has been observed in the retina of patients with Alzheimer's disease. The normal cellular function of gamma-synuclein remains unknown.
Interactions
Gamma-synuclein has been shown to interact with BUB1B.
See also
Synuclein
References
Further reading |
https://en.wikipedia.org/wiki/Crystal%20siltsnail | The crystal siltsnail, also known as the helicoid spring snail, scientific name Floridobia helicogyra, is a species of small freshwater snail with a gill and an operculum, an aquatic gastropod mollusk in the family Hydrobiidae.
This species is endemic to Hunter Spring, in Florida. It is threatened by habitat loss.
References
Molluscs of the United States
Floridobia
Hydrobiidae
Gastropods described in 1968
Taxonomy articles created by Polbot |
https://en.wikipedia.org/wiki/Ulyqbek%20Asanbayev | Ulyqbek Asanbayev (, Ūlyqbek Asanbaev) is retired Kazakh footballer of Uzbek descent.
Career statistics
Club
Last update: 2012
International
Statistics accurate as of match played 10 September 2008
Honours
MHSK Tashkent
Uzbek League (1): 1997
Dustlik
Uzbek League (1): 1999
Pakhtakor Tashkent
Uzbekistan Cup (1): 2001
Zhenis Astana
Kazakhstan Premier League (1): 2001
Kazakhstan Cup (1): 2000-01
Kairat
Kazakhstan Premier League (1): 2004
Kazakhstan Cup (1): 2003
Aktobe
Kazakhstan Premier League (3): 2007, 2008, 2009
Kazakhstan Cup (1): 2008
Ordabasy
Kazakhstan Cup (1): 2011
References
External links
Profile at National Team Website
1979 births
Living people
Sportspeople from Shymkent
Kazakhstani men's footballers
Kazakhstan men's international footballers
Kazakhstan Premier League players
FC Zhenis players
FC Kairat players
Pakhtakor Tashkent FK players
FC Aktobe players
FC Kyzylzhar players
FC Ordabasy players
FC Irtysh Pavlodar players
FC Okzhetpes players
Uzbekistani expatriate sportspeople in Kazakhstan
Men's association football midfielders |
https://en.wikipedia.org/wiki/Portsmouth%20Gaseous%20Diffusion%20Plant | The Portsmouth Gaseous Diffusion Plant is a facility located in Scioto Township, Pike County, Ohio, just south of Piketon, Ohio, that previously produced enriched uranium, including highly enriched weapons-grade uranium, for the United States Atomic Energy Commission (AEC), the U.S. nuclear weapons program and Navy nuclear propulsion; in later years, it produced low-enriched uranium for fuel for commercial nuclear power reactors. The site never hosted an operating nuclear reactor.
The plant, so named because of its proximity to the city of Portsmouth, Ohio, approximately 22 miles south of the site, was one of three gaseous diffusion plants in the U.S., alongside the K-25 plant in Oak Ridge, Tennessee, and the Paducah Gaseous Diffusion Plant near Paducah, Kentucky. The plant was constructed between 1952 and 1956, with the first enrichment cells going online in 1954.
The former plant facilities are currently undergoing decontamination and decommissioning (D&D). Some site facilities are overseen by the United States Enrichment Corporation, a subsidiary of Centrus Energy. The D&D work on the older facilities to prepare the site for future use is expected to continue through 2024 and is being conducted by Fluor-B&W Portsmouth LLC.
Design
The former gaseous diffusion plant covers of the site. The largest buildings – the process buildings – have a combined length of approximately , and cover about and contain of space. In use, the plant consumed a peak electrical demand of |
https://en.wikipedia.org/wiki/Iranians%20in%20Japan | Iranians in Japan (, , ) are a minority group, with official statistics recording about 5,000 Iranian migrants in the country. Part of the Iranian diaspora, most live in the Greater Tokyo Area.
Migration history
Ancient history
According to Akihiro Watanabe of the Nara National Research Institute for Cultural Properties, a mokkan (wooden tablet) dating back to the 7th century CE which was found in Nara Prefecture during the 1960s mentions a Persian official who lived and worked in Japan. Watanabe said that the official may have taught mathematics, citing Iran's expertise in the subject. The mokkan was deciphered in 2016 with the help of technology which allowed researchers to read characters not previously visible. Around the time the mokkan was inscribed, Nara would have been an ethnically diverse metropolitan area associated with the Silk Road and about to become Japan's capital city. Before the mokkan was discovered, the first written account of Persians in Japan was in the Nihon Shoki (The Chronicles of Japan, which was finished in 720). The book describes the arrival in Japan in 634 of several people from a place known in Japanese as Tokhārā (believed to be Tokharistan, which would have been part of the Sasanian Empire) and Dārā, a Persian man who worked for the emperor and returned to his homeland in 660. Another example of interaction between the Persians and the Japanese is the oldest known example of Persian writing in Japan, a one-page document with lines from th |
https://en.wikipedia.org/wiki/Infinite%20monkey%20theorem%20in%20popular%20culture | The infinite monkey theorem and its associated imagery is considered a popular and proverbial illustration of the mathematics of probability, widely known to the general public because of its transmission through popular culture rather than because of its transmission via the classroom.
However, this popularity as either presented to or taken in the public's mind often oversimplifies or confuses important aspects of the different scales of the concepts involved: infinity, probability, and time—all of these are in measures beyond average human experience and practical comprehension or comparison.
Popularity
The history of the imagery of "typing monkeys" dates back at least as far as Émile Borel's use of the metaphor in his essay in 1913, and this imagery has recurred many times since in a variety of media.
The Hoffmann and Hofmann paper (2001) referenced a collection compiled by Jim Reeds, titled "The Parable of the Monkeys – a.k.a. The Topos of the Monkeys and the Typewriters".
The enduring, widespread and popular nature of the knowledge of the theorem was noted in a 2001 paper, "Monkeys, Typewriters and Networks – the Internet in the Light of the Theory of Accidental Excellence". In their introduction to that paper, Hoffmann and Hofmann stated: "The Internet is home to a vast assortment of quotations and experimental designs concerning monkeys and typewriters. They all expand on the theory […] that if an infinite number of monkeys were left to bang on an infinite number o |
https://en.wikipedia.org/wiki/Ganglionic%20blocker | A ganglionic blocker (or ganglioplegic) is a type of medication that inhibits transmission between preganglionic and postganglionic neurons in the autonomic nervous system, often by acting as a nicotinic receptor antagonist. Nicotinic acetylcholine receptors are found on skeletal muscle, but also within the route of transmission for the parasympathetic and sympathetic nervous system (which together comprise the autonomic nervous system). More specifically, nicotinic receptors are found within the ganglia of the autonomic nervous system, allowing outgoing signals to be transmitted from the presynaptic to the postsynaptic cells. Thus, for example, blocking nicotinic acetylcholine receptors blocks both sympathetic (excitatory) and parasympathetic (calming) stimulation of the heart. The nicotinic antagonist hexamethonium, for example, does this by blocking the transmission of outgoing signals across the autonomic ganglia at the postsynaptic nicotinic acetylcholine receptor.
Because ganglionic blockers block both the parasympathetic nervous system and sympathetic nervous system, the effect of these drugs depends upon the dominant tone in the organ system.
The opposite of a ganglionic blocker is referred to as a ganglionic stimulant. Some substances can exhibit both stimulating and blocking effects on autonomic ganglia, depending on dosage and/or duration of action. An example for such a "dual" action is nicotine, which does this via depolarization block (see classification below |
https://en.wikipedia.org/wiki/Vala%20%28programming%20language%29 | Vala is an object-oriented programming language with a self-hosting compiler that generates C code and uses the GObject system.
Vala is syntactically similar to C# and includes notable features such as anonymous functions, signals, properties, generics, assisted memory management, exception handling, type inference, and foreach statements. Its developers, Jürg Billeter and Raffaele Sandrini, wanted to bring these features to the plain C runtime with little overhead and no special runtime support by targeting the GObject object system. Rather than compiling directly to machine code or assembly language, it compiles to a lower-level intermediate language. It source-to-source compiles to C, which is then compiled with a C compiler for a given platform, such as GCC or Clang.
Using functionality from native code libraries requires writing vapi files, defining the library interfaces. Writing these interface definitions is well-documented for C libraries. Bindings are already available for a large number of libraries, including libraries that are not based on GObject such as the multimedia library SDL and OpenGL.
Description
Vala is a programming language that combines the high-level build-time performance of scripting languages with the run-time performance of low-level programming languages. It aims to bring modern programming language features to GNOME developers without imposing any additional runtime requirements and without using a different ABI, compared to applications an |
https://en.wikipedia.org/wiki/URBI | Urbi is an open-source cross-platform software computing platform written in C++ used to develop applications for robotics and complex systems. Urbi is based on the UObject distributed C++ component architecture. It also includes the urbiscript orchestration language which is a parallel and event-driven script language. UObject components can be plugged into urbiscript and appear as native objects that can be scripted to specify their interactions and data exchanges. UObjects can be linked to the urbiscript interpreter, or executed as autonomous processes in "remote" mode.
The urbiscript language
The urbiscript language was created in 2003 by Jean-Christophe Baillie in the Cognitive Robotics Lab of ENSTA, Paris. It has been actively and further developed in the industry through the Gostai company founded in 2006. It is now an open source project, with a BSD license, available on GitHub.
The urbiscript language can be best described as an orchestration script language: like Lua in video games, urbiscript can be used to glue together C++ components into a functional behavior, the CPU-intensive algorithmic part being left to C++ and the behavior scripting part being left to the script language which is more flexible, easy to maintain and allows dynamic interaction during program execution. As an orchestration language, urbiscript also brings some useful abstractions to a program by having parallelism and event-based programming as part of the language semantics. The scripting |
https://en.wikipedia.org/wiki/Guanosine%20pentaphosphate | (p)ppGpp, guanosine pentaphosphate and tetraphosphate, also known as the "magic spot" nucleotides, are alarmones involved in the stringent response in bacteria that cause the inhibition of RNA synthesis when there is a shortage of amino acids. This inhibition by (p)ppGpp decreases translation in the cell, conserving amino acids present. Furthermore, ppGpp and pppGpp cause the up-regulation of many other genes involved in stress response such as the genes for amino acid uptake (from surrounding media) and biosynthesis.
Discovery
ppGpp and pppGpp were first identified by Michael Cashel in 1969. These nucleotides were found to accumulate rapidly in Escherichia coli cells starved for amino acids and inhibit synthesis of ribosomal and transfer RNAs. It is now known that (p)ppGpp is also produced in response to other stressors including carbon and phosphate starvation. Historically, literature surrounding (p)ppGpp have given conflicting findings and information on its role in bacterial stress responses.
Absence of (p)ppGpp
E.coli are shown to be more sensitive to accumulations of guanosine tetraphosphate than guanosine pentaphosphate. A complete absence of (p)ppGpp causes multiple amino acid requirements, poor survival of aged cultures, aberrant cell division, morphology, and immotility, as well as being locked in a growth mode during entry into starvation.
Synthesis and degradation of (p)ppGpp
The synthesis and degradation of (p)ppGpp have been most extensively characterize |
https://en.wikipedia.org/wiki/Khin | Khin is a classical membranophone used in Newar music. Khin are played in pair putting on lap by the players facing each other.
A Khin is made of a hollow wooden trunk with membrane covering both sides. The right side is covered with cow skin, while the left side is covered with goat skin. Both sides are attached with a black tuning paste called khau. The right hole of the trunk is narrower than the left one, and thus sound produced from the right side is sharper than the sound from left side.
It is played during 'Bhajans' and different festivals also like 'Ghintanghisi' and others.
References
Newar
Membranophones
Drums of Nepal |
https://en.wikipedia.org/wiki/CBV%20Sectors | CBV-Index is divided into 10 indices of the ten major industries of Vietnam economy (based on ICB-Industry Classification Benchmark, developed by FTSE and Dow Jones Limited, currently in use by NYSE).
These are 10 main industries that reflect Vietnam economic growth and have strong correlation with the macroeconomic cycle of Vietnam:
See also
CBV Index
CBV 20
CBV 10
External links
Overview of CBV Sectors from Bien Viet Securities JSC
List of Companies in CBV Sectors
Vietnamese stock market indices |
https://en.wikipedia.org/wiki/Whole-body%20vibration | Whole body vibration is a generic term used when vibrations (mechanical oscillations) of any frequency are transferred to the human body. Humans are exposed to vibration through a contact surface that is in a mechanical vibrating state. Humans are generally exposed to many different forms of vibration in their daily lives. This could be through a driver's seat, a moving train platform, a power tool, a training platform, or any one of countless other devices. It is a potential form of occupational hazard, particularly after years of exposure.
When high frequency vibrations (above 50 Hz) enter through the hands, occupational safety concerns may arise. For example, working with a jackhammer has been known to develop vibration white finger. Exposures and limits have been estimated in the ISO 5349-1 for hand-transmitted vibration.
Whole body vibration training as a form of physical exercise can offer some fitness and health benefits, but it is not clear if it is as beneficial as regular physical exercise. A 2018 meta-analysis showed that whole body vibration can improve bone mineral density in the lumbar spine of postmenopausal women as well as the femoral neck density of postmenopausal women younger than 65.
As a hazard
Humans are sensitive to mechanical oscillations ranging in frequency from well below 1 Hz up to 100 kHz. Lower frequencies of vibration lead to human motion sickness while higher frequencies can lead to general annoyance and discomfort. The minimization of dis |
https://en.wikipedia.org/wiki/Cang%20Hui | Cang Hui () is a mathematical ecologist at Stellenbosch University. His research interests are proposing models and theories for explaining emerging patterns of biodiversity, networks and adaptive traits in ecology and evolution.
Background
Hui was born in Xi'an and received his BSc (1998) in Applied Mathematics from Xi'an Jiaotong University, his MSc (2001) in Applied Mathematics from Lanzhou University, and his PhD (2004) in Mathematical Ecology from the same university. Hui was a Researcher at the DST-NRF Centre of Excellence for Invasion Biology from 2008 to 2013, and has remained a Core-Team Member of the center since. Hui was appointed Visiting Professor in the MOE Key Laboratory of Western China's Environmental Systems (also known as the Research School of Arid Environment & Climate Change) from 2006 to 2009 and Adjunct Professor since 2011 at Lanzhou University. In January 2014, Hui was promoted to Full Professor in the Department of Mathematical Sciences at Stellenbosch University for his appointment as the South African Research Chair in Mathematical & Theoretical Physical Biosciences by the National Research Foundation of South Africa. This appointment is co-hosted by the African Institute for Mathematical Sciences, located in Cape Town.
In 2011 he was awarded the Elsevier Young Scientist Award at the National Research Foundation of South Africa.
Major works
In 2021, Hui and colleague David Mark Richardson published the book Invading Ecological Networks. This |
https://en.wikipedia.org/wiki/Anti-Gold%20Futures%20Act%20of%201864 | The Anti-Gold Futures Act of 1864 () was the first instance of United States Federal regulation of derivatives. More formally titled "An Act to Prohibit Certain Sales of Gold and Foreign Exchange," the Act was passed by Congress on June 17, 1864.
It was a response to Congressional perceptions that the low value the fiat currency greenbacks were then trading at relative to gold was as a result of a failure of the private market. The Act prohibited the trading of gold futures, and also criminalized the sale of foreign exchange more than ten days in the future. Congress's action was followed by a further sharp drop in the value of the greenbacks. Two weeks later Congress repealed the act.
References
United States federal commodity and futures legislation
1864 in American law
1864 in American politics
Repealed United States legislation |
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