Biological Process stringlengths 7 1.01k | Cellular Component stringlengths 6 867 | Molecular Function stringlengths 11 871 | Organism stringlengths 8 73 | Keywords stringlengths 1 810 | Sequence 10 stringlengths 5 10 | Sequence stringlengths 5 1.02k | Combined stringlengths 136 3.91k |
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cell-cell signaling cellular response to retinoic acid in utero embryonic development placenta development skin development spermatogenesis | cell junction; connexin complex; cytoplasm; gap junction; intracellular membrane-bounded organelle | gap junction channel activity | Homo sapiens | Cell junction Cell membrane Deafness Disease variant Gap junction Membrane Non-syndromic deafness Palmoplantar keratoderma Reference proteome Transmembrane Transmembrane helix | MDWKTLQALL | MDWKTLQALLSGVNKYSTAFGRIWLSVVFVFRVLVYVVAAERVWGDEQKDFDCNTKQPGCTNVCYDNYFPISNIRLWALQLIFVTCPSLLVILHVAYREERERRHRQKHGDQCAKLYDNAGKKHGGLWWTYLFSLIFKLIIEFLFLYLLHTLWHGFNMPRLVQCANVAPCPNIVDCYIARPTEKKIFTYFMVGASAVCIVLTICELCYLICHRVLRGLHKDKPRGGCSPSSSASRASTCRCHHKLVEAGEVDPDPGNNKLQASAPNLTPI | cell-cell signaling cellular response to retinoic acid in utero embryonic development placenta development skin development spermatogenesis cell junction; connexin complex; cytoplasm; gap junction; intracellular membrane-bounded organelle gap junction channel activity Homo sapiens Cell junction Cell membrane Deafness D... |
cellular response to transforming growth factor beta stimulus positive regulation of transcription by RNA polymerase II protein autophosphorylation | cytoplasm; cytosol; Golgi apparatus; Golgi-associated vesicle; nucleoplasm; perinuclear region of cytoplasm; plasma membrane | ATP binding non-membrane spanning protein tyrosine kinase activity protein serine kinase activity protein serine/threonine kinase activity RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | 3D-structure ATP-binding Cytoplasm Kinase Lipoprotein Membrane Myristate Nucleotide-binding Palmitate Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase | MGHALCVCSR | MGHALCVCSRGTVIIDNKRYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPGQHTTQI | cellular response to transforming growth factor beta stimulus positive regulation of transcription by RNA polymerase II protein autophosphorylation cytoplasm; cytosol; Golgi apparatus; Golgi-associated vesicle; nucleoplasm; perinuclear region of cytoplasm; plasma membrane ATP binding non-membrane spanning protein tyros... |
aspartate family amino acid metabolic process aspartate transmembrane transport gluconeogenesis L-glutamate transmembrane transport malate-aspartate shuttle response to calcium ion | membrane; mitochondrial inner membrane; mitochondrion | 3-sulfino-L-alanine: proton, glutamate antiporter activity acidic amino acid transmembrane transporter activity aspartate:glutamate, proton antiporter activity calcium ion binding identical protein binding L-aspartate transmembrane transporter activity L-glutamate transmembrane transporter activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Calcium Disease variant Membrane Metal-binding Mitochondrion Mitochondrion inner membrane Reference proteome Repeat Transmembrane Transmembrane helix Transport | MAVKVQTTKR | MAVKVQTTKRGDPHELRNIFLQYASTEVDGERYMTPEDFVQRYLGLYNDPNSNPKIVQLLAGVADQTKDGLISYQEFLAFESVLCAPDSMFIVAFQLFDKSGNGEVTFENVKEIFGQTIIHHHIPFNWDCEFIRLHFGHNRKKHLNYTEFTQFLQELQLEHARQAFALKDKSKSGMISGLDFSDIMVTIRSHMLTPFVEENLVSAAGGSISHQVSFSYFNAFNSLLNNMELVRKIYSTLAGTRKDVEVTKEEFAQSAIRYGQVTPLEIDILYQLADLYNASGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIW... | aspartate family amino acid metabolic process aspartate transmembrane transport gluconeogenesis L-glutamate transmembrane transport malate-aspartate shuttle response to calcium ion membrane; mitochondrial inner membrane; mitochondrion 3-sulfino-L-alanine: proton, glutamate antiporter activity acidic amino acid transmem... |
dopamine transport dopamine uptake epinephrine transport epinephrine uptake histamine metabolic process histamine transport histamine uptake monoamine transport monoatomic ion transport monocarboxylic acid transport neurotransmitter transport norepinephrine transport norepinephrine uptake organic anion transport organi... | apical plasma membrane; basolateral plasma membrane; endomembrane system; membrane; mitochondrial membrane; neuronal cell body; nuclear outer membrane; plasma membrane; presynapse | monoamine transmembrane transporter activity neurotransmitter transmembrane transporter activity organic anion transmembrane transporter activity organic cation transmembrane transporter activity quaternary ammonium group transmembrane transporter activity spermidine transmembrane transporter activity toxin transmembra... | Homo sapiens | 3D-structure Cell membrane Glycoprotein Ion transport Membrane Mitochondrion Nucleus Reference proteome Transmembrane Transmembrane helix Transport | MPSFDEALQR | MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPEEEWNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAPLVPCRGGWRYAQAHSTIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYLLSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNGKYLS... | dopamine transport dopamine uptake epinephrine transport epinephrine uptake histamine metabolic process histamine transport histamine uptake monoamine transport monoatomic ion transport monocarboxylic acid transport neurotransmitter transport norepinephrine transport norepinephrine uptake organic anion transport organi... |
glycosphingolipid biosynthetic process oligosaccharide biosynthetic process protein O-linked glycosylation | Golgi membrane; membrane | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity | Homo sapiens | Blood group antigen Glycoprotein Glycosyltransferase Golgi apparatus Lipid metabolism Magnesium Membrane Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix | MASALWTVLP | MASALWTVLPSRMSLRSLKWSLLLLSLLSFFVMWYLSLPHYNVIERVNWMYFYEYEPIYRQDFHFTLREHSNCSHQNPFLVILVTSHPSDVKARQAIRVTWGEKKSWWGYEVLTFFLLGQEAEKEDKMLALSLEDEHLLYGDIIRQDFLDTYNNLTLKTIMAFRWVTEFCPNAKYVMKTDTDVFINTGNLVKYLLNLNHSEKFFTGYPLIDNYSYRGFYQKTHISYQEYPFKVFPPYCSGLGYIMSRDLVPRIYEMMGHVKPIKFEDVYVGICLNLLKVNIHIPEDTNLFFLYRIHLDVCQLRRVIAAHGFSSKEIITFW... | glycosphingolipid biosynthetic process oligosaccharide biosynthetic process protein O-linked glycosylation Golgi membrane; membrane galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Homo sapiens Blood group... |
DNA repair DNA strand invasion double-strand break repair via homologous recombination interstrand cross-link repair reciprocal meiotic recombination regulation of cell cycle telomere maintenance telomere maintenance via recombination | centrosome; chromosome, telomeric region; cytoplasm; nucleoplasm; nucleus; Rad51B-Rad51C-Rad51D-XRCC2 complex; replication fork | ATP binding ATP hydrolysis activity ATP-dependent activity, acting on DNA ATP-dependent DNA damage sensor activity DNA binding gamma-tubulin binding single-stranded DNA binding | Homo sapiens | 3D-structure Alternative splicing ATP-binding Chromosome Cytoplasm Cytoskeleton DNA damage DNA recombination DNA repair DNA-binding Nucleotide-binding Nucleus Reference proteome Telomere | MGVLRVGLCP | MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKALVALRRVLLAQFSAFPVNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGGPGSGKTQVCLCMAANVAHGLQQNVLYVDSNGGLTASRLLQLLQAKTQDEEEQAEALRRIQVVHAFDIFQMLDVLQELRGTVAQQVTGSSGTVKVVVVDSVTAVVSPLLGGQQREGLALMMQLARELKTLARDLGMAVVVTNHITRDRDSGRLKPALGRSWSFVPSTRILLDTIEGAGASGGRRMACLAKSSRQPTGFQEMVDIGTWGTSEQS... | DNA repair DNA strand invasion double-strand break repair via homologous recombination interstrand cross-link repair reciprocal meiotic recombination regulation of cell cycle telomere maintenance telomere maintenance via recombination centrosome; chromosome, telomeric region; cytoplasm; nucleoplasm; nucleus; Rad51B-Rad... |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway cellular response to electrical stimulus cytoskeleton organization negative regulation of dopamine receptor signaling pathway positive regulation of filopodium assembly protein localization to plasma membrane regulation of cell shape synapse matu... | apicolateral plasma membrane; axon; basolateral plasma membrane; cytoplasmic side of plasma membrane; cytoplasmic vesicle; dendritic spine; filopodium membrane; nucleoplasm; plasma membrane; postsynaptic density | D3 dopamine receptor binding | Homo sapiens | Acetylation Alternative splicing Cell membrane Cell projection Cell shape Coiled coil Lipoprotein Membrane Methylation Palmitate Phosphoprotein Prenylation Reference proteome Synapse | MEVLAAETTS | MEVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTPSSASEGDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPVRAPAPSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPLRTVDGSPMMKAAMYSVEITVEKDKVTGETRVLSSTTLLPRQPLPLGIKVYEDETKVVHAVDGTAENGIHPLSSSEVDELIHKADEVTLSEAGSTAGAAETRGAVEGAARTTPSRREITGVQAQPGEATSGPPGIQPGQEPPVTMIFMGYQNVEDEAETKKVLGL... | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway cellular response to electrical stimulus cytoskeleton organization negative regulation of dopamine receptor signaling pathway positive regulation of filopodium assembly protein localization to plasma membrane regulation of cell shape synapse matu... |
proteolysis signal transduction | membrane; plasma membrane | serine-type endopeptidase activity | Homo sapiens | Alternative splicing Hydrolase Membrane Protease Reference proteome Serine protease Transmembrane Transmembrane helix | MGRVEDGGTT | MGRVEDGGTTEELEDWDPGTSALPAPGIKQGPREQTGTGPLSQKCWEPEPDAPSQPGPALWSRGRARTQALAGGSSLQQLDPENTGFIGADTFTGLVHSHELPLDPAKLDMLVALAQSNEQGQVCYQELVDLISSKRSSSFKRAIANGQRALPRDGPLDEPGLGVYKRFVRYVAYEILPCEVDRRWYFYRHRSCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPEYMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYLAGVLAGSLTVSITDMRAPVVGGSGGVYALCS... | proteolysis signal transduction membrane; plasma membrane serine-type endopeptidase activity Homo sapiens Alternative splicing Hydrolase Membrane Protease Reference proteome Serine protease Transmembrane Transmembrane helix MGRVEDGGTT MGRVEDGGTTEELEDWDPGTSALPAPGIKQGPREQTGTGPLSQKCWEPEPDAPSQPGPALWSRGRARTQALAGGSSLQQLDPENT... |
angiotensin maturation central nervous system maturation endosomal lumen acidification eye pigmentation Golgi lumen acidification head morphogenesis intracellular pH reduction lysosomal lumen acidification positive regulation of canonical Wnt signaling pathway positive regulation of transforming growth factor beta1 pro... | autophagosome membrane; axon; clathrin-coated vesicle membrane; dendritic spine membrane; endoplasmic reticulum membrane; endosome membrane; external side of plasma membrane; extracellular exosome; ficolin-1-rich granule membrane; Golgi membrane; lysosomal membrane; lysosome; membrane; plasma membrane; postsynaptic mem... | signaling receptor activity | Homo sapiens | 3D-structure Alternative splicing Cell membrane Cell projection Cleavage on pair of basic residues Congenital disorder of glycosylation Cytoplasmic vesicle Disease variant Endoplasmic reticulum Endosome Epilepsy Intellectual disability Lysosome Membrane Neurodegeneration Parkinsonism Phosphoprotein Postsynaptic cell me... | MAVFVVLLAL | MAVFVVLLALVAGVLGNEFSILKSPGSVVFRNGNWPIPGERIPDVAALSMGFSVKEDLSWPGLAVGNLFHRPRATVMVMVKGVNKLALPPGSVISYPLENAVPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFEDLSVTLRQLRNRLFQENSVLSSLPLNSLSRNNEVDLLFLSELQVLHDISSLLSRHKHLAKDHSPDLYSLELAGLDEIGKRYGEDSEQFRDASKILVDALQKFADDMYSLYGGNAVVELVTVKSFDTSLIRKTRTILEAKQAKNPASPYNLAYKYNFEYSVVFNMVLWIMIALALA... | angiotensin maturation central nervous system maturation endosomal lumen acidification eye pigmentation Golgi lumen acidification head morphogenesis intracellular pH reduction lysosomal lumen acidification positive regulation of canonical Wnt signaling pathway positive regulation of transforming growth factor beta1 pro... |
cell-cell signaling Ras protein signal transduction regulation of MAPK cascade signal transduction | cytoplasm; cytosol; endosome; nucleoplasm; nucleus; plasma membrane | phosphotyrosine residue binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Endosome Nucleus Phosphoprotein Reference proteome Repeat SH2 domain SH3 domain | MEAVAKFDFT | MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVGEEIRPSMNRKLSDHPPTLPLQQHQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDINDGHCGTGLGSEMNAALMHRRHTDPVQLQAAGRVRWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLF... | cell-cell signaling Ras protein signal transduction regulation of MAPK cascade signal transduction cytoplasm; cytosol; endosome; nucleoplasm; nucleus; plasma membrane phosphotyrosine residue binding Homo sapiens 3D-structure Acetylation Alternative splicing Cytoplasm Endosome Nucleus Phosphoprotein Reference proteome R... |
DNA replication DNA replication, removal of RNA primer mismatch repair RNA catabolic process | cytosol; nucleoplasm; ribonuclease H2 complex | metal ion binding RNA binding RNA nuclease activity RNA-DNA hybrid ribonuclease activity | Homo sapiens | 3D-structure Acetylation Aicardi-Goutieres syndrome Disease variant Endonuclease Hydrolase Metal-binding Nuclease Nucleus Phosphoprotein Reference proteome | MDLSELERDN | MDLSELERDNTGRCRLSSPVPAVCRKEPCVLGVDEAGRGPVLGPMVYAICYCPLPRLADLEALKVADSKTLLESERERLFAKMEDTDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHDTATGLIQYALDQGVNVTQVFVDTVGMPETYQARLQQSFPGIEVTVKAKADALYPVVSAASICAKVARDQAVKKWQFVEKLQDLDTDYGSGYPNDPKTKAWLKEHVEPVFGFPQFVRFSWRTAQTILEKEAEDVIWEDSASENQEGLRKITSYFLNEGSQARPRSSHRYFLERGLESATSL | DNA replication DNA replication, removal of RNA primer mismatch repair RNA catabolic process cytosol; nucleoplasm; ribonuclease H2 complex metal ion binding RNA binding RNA nuclease activity RNA-DNA hybrid ribonuclease activity Homo sapiens 3D-structure Acetylation Aicardi-Goutieres syndrome Disease variant Endonucleas... |
eukaryotic translation initiation factor 2 complex assembly | cytoplasm | ATP binding magnesium ion binding protein folding chaperone | Homo sapiens | 3D-structure ATP-binding Chaperone Cytoplasm Magnesium Metal-binding Nucleotide-binding Phosphoprotein Reference proteome | MKKEHVLHCQ | MKKEHVLHCQFSAWYPFFRGVTIKSVILPLPQNVKDYLLDDGTLVVSGRDDPPTHSQPDSDDEAEEIQWSDDENTATLTAPEFPEFATKVQEAINSLGGSVFPKLNWSAPRDAYWIAMNSSLKCKTLSDIFLLFKSSDFITRDFTQPFIHCTDDSPDPCIEYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEIRRCIQDFFKKHIQYKFLDEDFVFDIYRDSRGKVWLIDFNPFGEVTDSLLFTWEELISENNLNGDFSEVDAQEQDSPAFRCTNSEVTVQPSPYLSYRLPKDFVDLSTGEDAH... | eukaryotic translation initiation factor 2 complex assembly cytoplasm ATP binding magnesium ion binding protein folding chaperone Homo sapiens 3D-structure ATP-binding Chaperone Cytoplasm Magnesium Metal-binding Nucleotide-binding Phosphoprotein Reference proteome MKKEHVLHCQ MKKEHVLHCQFSAWYPFFRGVTIKSVILPLPQNVKDYLLDDGTL... |
cellular glucuronidation estrogen metabolic process steroid metabolic process xenobiotic metabolic process | endoplasmic reticulum membrane; membrane | glucuronosyltransferase activity | Homo sapiens | 3D-structure Endoplasmic reticulum Glycoprotein Glycosyltransferase Lipid metabolism Membrane Reference proteome Signal Steroid metabolism Transferase Transmembrane Transmembrane helix | MSLKWMSVFL | MSLKWMSVFLLMQLSCYFSSGSCGKVLVWPTEYSHWINMKTILEELVQRGHEVIVLTSSASILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWTYSISKNTFWSYFSQLQELCWEYSDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFLYSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLYFDFWFQAYDLKKWDQFYSEVLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMISNMSEE... | cellular glucuronidation estrogen metabolic process steroid metabolic process xenobiotic metabolic process endoplasmic reticulum membrane; membrane glucuronosyltransferase activity Homo sapiens 3D-structure Endoplasmic reticulum Glycoprotein Glycosyltransferase Lipid metabolism Membrane Reference proteome Signal Steroi... |
cilium movement inner dynein arm assembly motile cilium assembly outer dynein arm assembly positive regulation of motile cilium assembly protein localization to cilium | apical plasma membrane; centriolar satellite; cytoplasm; dynein axonemal particle | metal ion binding molecular adaptor activity protein folding chaperone | Homo sapiens | 3D-structure Alternative splicing Cell membrane Ciliopathy Cytoplasm Cytoskeleton Disease variant Kartagener syndrome Membrane Metal-binding Primary ciliary dyskinesia Reference proteome Zinc Zinc-finger | MGDLELLLPG | MGDLELLLPGEAEVLVRGLRSFPLREMGSEGWNQQHENLEKLNMQAILDATVSQGEPIQELLVTHGKVPTLVEELIAVEMWKQKVFPVFCRVEDFKPQNTFPIYMVVHHEASIINLLETVFFHKEVCESAEDTVLDLVDYCHRKLTLLVAQSGCGGPPEGEGSQDSNPMQELQKQAELMEFEIALKALSVLRYITDCVDSLSLSTLSRMLSTHNLPCLLVELLEHSPWSRREGGKLQQFEGSRWHTVAPSEQQKLSKLDGQVWIALYNLLLSPEAQARYCLTSFAKGRLLKLRAFLTDTLLDQLPNLAHLQSFLAHLTLT... | cilium movement inner dynein arm assembly motile cilium assembly outer dynein arm assembly positive regulation of motile cilium assembly protein localization to cilium apical plasma membrane; centriolar satellite; cytoplasm; dynein axonemal particle metal ion binding molecular adaptor activity protein folding chaperone... |
apoptotic process DNA damage response intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress negative regulation of PERK-mediated unfolded protein response negative regulation of phosphoprotein phosphatase activity negative regulation of protein dephosphorylation positive regulation of endopl... | cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; membrane; mitochondrial outer membrane; mitochondrion; protein phosphatase type 1 complex | protein kinase binding protein phosphatase 1 binding protein phosphatase activator activity protein phosphatase regulator activity | Homo sapiens | 3D-structure Alternative splicing Apoptosis Endoplasmic reticulum Membrane Mitochondrion Mitochondrion outer membrane Phosphoprotein Reference proteome Repeat Stress response Translation regulation Ubl conjugation | MAPGQAPHQA | MAPGQAPHQATPWRDAHPFFLLSPVMGLLSRAWSRLRGLGPLEPWLVEAVKGAALVEAGLEGEARTPLAIPHTPWGRRPEEEAEDSGGPGEDRETLGLKTSSSLPEAWGLLDDDDGMYGEREATSVPRGQGSQFADGQRAPLSPSLLIRTLQGSDKNPGEEKAEEEGVAEEEGVNKFSYPPSHRECCPAVEEEDDEEAVKKEAHRTSTSALSPGSKPSTWVSCPGEEENQATEDKRTERSKGARKTSVSPRSSGSDPRSWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAPAQRPQLKSWWCQPSDEEEGEVKALGAA... | apoptotic process DNA damage response intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress negative regulation of PERK-mediated unfolded protein response negative regulation of phosphoprotein phosphatase activity negative regulation of protein dephosphorylation positive regulation of endopl... |
endothelin receptor signaling pathway epidermal growth factor receptor signaling pathway insulin receptor signaling pathway lens morphogenesis in camera-type eye positive regulation of cell population proliferation positive regulation of GTPase activity positive regulation of MAPK cascade positive regulation of peptidy... | cytoplasm; focal adhesion; membrane | guanyl-nucleotide exchange factor activity kinase binding phosphotyrosine residue binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cell junction Cytoplasm Guanine-nucleotide releasing factor Methylation Phosphoprotein Reference proteome SH2 domain | MAAGKFASLP | MAAGKFASLPRNMPVNHQFPLASSMDLLSSRSPLAEHRPDAYQDVSIHGTLPRKKKGPPPIRSCDDFSHMGTLPHSKSPRQNSPVTQDGIQESPWQDRHGETFTFRDPHLLDPTVEYVKFSKERHIMDRTPEKLKKELEEELLLSSEDLRSHAWYHGRIPRQVSENLVQRDGDFLVRDSLSSPGNFVLTCQWKNLAQHFKINRTVLRLSEAYSRVQYQFEMESFDSIPGLVRCYVGNRRPISQQSGAIIFQPINRTVPLRCLEEHYGTSPGQAREGSLTKGRPDVAKRLSLTMGGVQAREQNLPRGNLLRNKEKSGSQPA... | endothelin receptor signaling pathway epidermal growth factor receptor signaling pathway insulin receptor signaling pathway lens morphogenesis in camera-type eye positive regulation of cell population proliferation positive regulation of GTPase activity positive regulation of MAPK cascade positive regulation of peptidy... |
rRNA processing tRNA 5'-leader removal tRNA processing | cytoplasm; intracellular membrane-bounded organelle; multimeric ribonuclease P complex; nucleolar ribonuclease P complex; nucleolus; nucleoplasm; nucleus; ribonuclease MRP complex | ribonuclease P activity ribonuclease P RNA binding RNA binding | Homo sapiens | 3D-structure Cytoplasm Direct protein sequencing Nucleus Reference proteome RNA-binding rRNA processing tRNA processing | MAENREPRGA | MAENREPRGAVEAELDPVEYTLRKRLPSRLPRRPNDIYVNMKTDFKAQLARCQKLLDGGARGQNACSEIYIHGLGLAINRAINIALQLQAGSFGSLQVAANTSTVELVDELEPETDTREPLTRIRNNSAIHIRVFRVTPK | rRNA processing tRNA 5'-leader removal tRNA processing cytoplasm; intracellular membrane-bounded organelle; multimeric ribonuclease P complex; nucleolar ribonuclease P complex; nucleolus; nucleoplasm; nucleus; ribonuclease MRP complex ribonuclease P activity ribonuclease P RNA binding RNA binding Homo sapiens 3D-struct... |
endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) tRNA 5'-leader removal | multimeric ribonuclease P complex; nucleolar ribonuclease P complex; nucleoplasm; nucleus; ribonuclease MRP complex | ribonuclease P activity ribonuclease P RNA binding | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Nucleus Reference proteome RNA-binding rRNA processing tRNA processing | MATLRRLREA | MATLRRLREAPRHLLVCEKSNFGNHKSRHRHLVQTHYYNYRVSFLIPECGILSEELKNLVMNTGPYYFVKNLPLHELITPEFISTFIKKGSCYALTYNTHIDEDNTVALLPNGKLILSLDKDTYEETGLQGHPSQFSGRKIMKFIVSIDLMELSLNLDSKKYERISWSFKEKKPLKFDFLLAWHKTGSEESTMMSYFSKYQIQEHQPKVALSTLRDLQCPVLQSSELEGTPEVSCRALELFDWLGAVFSNVDLNNEPNNFISTYCCPEPSTVVAKAYLCTITGFILPEKICLLLEHLCHYFDEPKLAPWVTLSVQGFADS... | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) tRNA 5'-leader removal multimeric ribonuclease P complex; nucleolar ribonuclease P complex; nucleoplasm; nucleus; ribonuclease MRP complex ribonuclease P activity ribonucle... |
formation of cytoplasmic translation initiation complex translational initiation viral translational termination-reinitiation | cytoplasm; cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; perinuclear region of cytoplasm | RNA binding translation initiation factor activity | Homo sapiens | 3D-structure Cytoplasm Direct protein sequencing Initiation factor Nucleus Phosphoprotein Protein biosynthesis Reference proteome RNA-binding | MPTGDFDSKP | MPTGDFDSKPSWADQVEEEGEDDKCVTSELLKGIPLATGDTSPEPELLPGAPLPPPKEVINGNIKTVTEYKIDEDGKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLNCQEEEDPMNKLKGQKIVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEPVQATQNKTGKYVPPSLRDGASRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN | formation of cytoplasmic translation initiation complex translational initiation viral translational termination-reinitiation cytoplasm; cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; perinuclear region of cytoplasm RNA binding tr... |
formation of cytoplasmic translation initiation complex translational initiation | cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex | identical protein binding translation initiation factor activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Coiled coil Cytoplasm Direct protein sequencing Initiation factor Isopeptide bond Phosphoprotein Protein biosynthesis Reference proteome Ubl conjugation | MAAAAAAAGD | MAAAAAAAGDSDSWDADAFSVEDPVRKVGGGGTAGGDRWEGEDEDEDVKDNWDDDDDEKKEEAEVKPEVKISEKKKIAEKIKEKERQQKKRQEEIKKRLEEPEEPKVLTPEEQLADKLRLKKLQEESDLELAKETFGVNNAVYGIDAMNPSSRDDFTEFGKLLKDKITQYEKSLYYASFLEVLVRDVCISLEIDDLKKITNSLTVLCSEKQKQEKQSKAKKKKKGVVPGGGLKATMKDDLADYGGYDGGYVQDYEDFM | formation of cytoplasmic translation initiation complex translational initiation cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex identical protein binding translation initiation factor activity Homo sapiens 3D-structure Acetylation ... |
apoptotic process cytoplasmic sequestering of NF-kappaB negative regulation of apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of MAPK cascade negative regulation of NF-kappaB transcription factor activity negative regulation of release of cyto... | cytoplasm; cytoskeleton; cytosol; intermediate filament cytoskeleton; neuron projection; nucleoplasm; nucleus; plasma membrane; proteasome complex | cytoskeletal protein binding protein-macromolecule adaptor activity RNA polymerase II-specific DNA-binding transcription factor binding transcription factor binding transmembrane transporter binding | Homo sapiens | 3D-structure Alternative splicing ANK repeat Apoptosis Chaperone Cytoplasm Nucleus Reference proteome Repeat | MEGCVSNLMV | MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG | apoptotic process cytoplasmic sequestering of NF-kappaB negative regulation of apoptotic process negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of MAPK cascade negative regulation of NF-kappaB transcription factor activity negative regulation of release of cyto... |
calcium ion homeostasis cellular response to ATP photoreceptor cell maintenance positive regulation of cytosolic calcium ion concentration | blood microparticle; cell periphery; cuticular plate; cytoplasm; muscle tendon junction; neuromuscular junction; photoreceptor inner segment; photoreceptor outer segment; sarcolemma; stereocilium | calcium ion binding integrin binding magnesium ion binding protein homodimerization activity | Homo sapiens | Alternative splicing Calcium Cell membrane Cell projection Cilium Cytoplasm Deafness Disease variant Magnesium Membrane Metal-binding Non-syndromic deafness Reference proteome Repeat Retinitis pigmentosa Usher syndrome | MGNKQTIFTE | MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLIIQMPELRENPFKERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI | calcium ion homeostasis cellular response to ATP photoreceptor cell maintenance positive regulation of cytosolic calcium ion concentration blood microparticle; cell periphery; cuticular plate; cytoplasm; muscle tendon junction; neuromuscular junction; photoreceptor inner segment; photoreceptor outer segment; sarcolemma... |
axon guidance axonogenesis dendrite morphogenesis glucose homeostasis negative regulation of adipose tissue development negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymer... | chromatin; cytosol; nucleoplasm; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding zinc ion binding | Homo sapiens | Activator Alternative splicing Disease variant DNA-binding Metal-binding Nucleus Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger | MDVLASYSIF | MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQTCLELERYLQTEPRRISETFGEDLDCFLHASPPPCIEESFRRLDPLLLPVEAAICEKSSAVDILLSRDKLLSETCLSLQPASSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALSSVKVGGVATAAAAVTAAGAVKSGQSDSDQGGLGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI | axon guidance axonogenesis dendrite morphogenesis glucose homeostasis negative regulation of adipose tissue development negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymer... |
epithelial cell differentiation response to bacterium | apical plasma membrane urothelial plaque; extracellular exosome; membrane | structural molecule activity | Homo sapiens | Glycoprotein Membrane Reference proteome Transmembrane Transmembrane helix | MAKDNSTVRC | MAKDNSTVRCFQGLLIFGNVIIGCCGIALTAECIFFVSDQHSLYPLLEATDNDDIYGAAWIGIFVGICLFCLSVLGIVGIMKSSRKILLAYFILMFIVYAFEVASCITAATQQDFFTPNLFLKQMLERYQNNSPPNNDDQWKNNGVTKTWDRLMLQDNCCGVNGPSDWQKYTSAFRTENNDADYPWPRQCCVMNNLKEPLNLEACKLGVPGFYHNQGCYELISGPMNRHAWGVAWFGFAILCWTFWVLLGTMFYWSRIEY | epithelial cell differentiation response to bacterium apical plasma membrane urothelial plaque; extracellular exosome; membrane structural molecule activity Homo sapiens Glycoprotein Membrane Reference proteome Transmembrane Transmembrane helix MAKDNSTVRC MAKDNSTVRCFQGLLIFGNVIIGCCGIALTAECIFFVSDQHSLYPLLEATDNDDIYGAAWIGIF... |
Golgi to vacuole transport intracellular protein transport vesicle-mediated transport | AP-1 adaptor complex; endosome membrane; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; membrane; transport vesicle | clathrin adaptor activity | Homo sapiens | 3D-structure Cytoplasmic vesicle Endosome Golgi apparatus Host-virus interaction Membrane Protein transport Reference proteome Transport | MVVPSLKLQD | MVVPSLKLQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHMLGYPAHFGQMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLSTMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPCAQLLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQVQILRLLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTIMDIRSAAGLRVLAVNILGRFLLN... | Golgi to vacuole transport intracellular protein transport vesicle-mediated transport AP-1 adaptor complex; endosome membrane; Golgi apparatus; Golgi membrane; Golgi-associated vesicle; membrane; transport vesicle clathrin adaptor activity Homo sapiens 3D-structure Cytoplasmic vesicle Endosome Golgi apparatus Host-viru... |
cholesterol biosynthetic process via desmosterol cholesterol biosynthetic process via lathosterol lipid metabolic process | endoplasmic reticulum membrane; membrane | C-5 sterol desaturase activity delta7-sterol 5(6)-desaturase activity iron ion binding | Homo sapiens | Disease variant Endoplasmic reticulum Iron Lipid biosynthesis Lipid metabolism Membrane Oxidoreductase Phosphoprotein Reference proteome Steroid biosynthesis Steroid metabolism Sterol biosynthesis Sterol metabolism Transmembrane Transmembrane helix | MDLVLRVADY | MDLVLRVADYYFFTPYVYPATWPEDDIFRQAISLLIVTNVGAYILYFFCATLSYYFVFDHALMKHPQFLKNQVRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELVVSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQILQPFINGSAHHTDHHMFFDYNYGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE | cholesterol biosynthetic process via desmosterol cholesterol biosynthetic process via lathosterol lipid metabolic process endoplasmic reticulum membrane; membrane C-5 sterol desaturase activity delta7-sterol 5(6)-desaturase activity iron ion binding Homo sapiens Disease variant Endoplasmic reticulum Iron Lipid biosynth... |
phagocytosis regulation of immune system process signal transduction | cell surface; membrane; plasma membrane | protein tyrosine kinase binding | Homo sapiens | Glycoprotein Immunoglobulin domain Membrane Reference proteome Signal Transmembrane Transmembrane helix | MGPPSAAPRG | MGPPSAAPRGGHRPWQGLLITASLLTFWHPPTTVQFTIEALPSSAAEGKDVLLLACNISETIQAYYWHKGKTAEGSPLIAGYITDIQANIPGAAYSGRETVYPNGSLLFQNITLEDAGSYTLRTINASYDSDQATGQLHVHQNNVPGLPVGAVAGIVTGVLVGVALVAALVCFLLLSRTGRASIQRDLREQPPPASTPGHGPSHRSTFSAPLPSPRTATPIYEELLYSDANIYCQIDHKADVVS | phagocytosis regulation of immune system process signal transduction cell surface; membrane; plasma membrane protein tyrosine kinase binding Homo sapiens Glycoprotein Immunoglobulin domain Membrane Reference proteome Signal Transmembrane Transmembrane helix MGPPSAAPRG MGPPSAAPRGGHRPWQGLLITASLLTFWHPPTTVQFTIEALPSSAAEGKDV... |
2-oxoglutarate metabolic process female gonad development glutathione metabolic process glyoxylate cycle isocitrate metabolic process NADP metabolic process regulation of phospholipid biosynthetic process regulation of phospholipid catabolic process response to oxidative stress response to steroid hormone tricarboxylic... | cytoplasm; cytosol; extracellular exosome; extracellular region; ficolin-1-rich granule lumen; mitochondrion; peroxisomal matrix; peroxisome; secretory granule lumen; tertiary granule lumen | cadherin binding identical protein binding isocitrate dehydrogenase (NADP+) activity magnesium ion binding NAD binding NADP binding protein homodimerization activity | Homo sapiens | 3D-structure Acetylation Cytoplasm Direct protein sequencing Glyoxylate bypass Magnesium Manganese Metal-binding NADP Oxidoreductase Peroxisome Phosphoprotein Reference proteome Tricarboxylic acid cycle | MSKKISGGSV | MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQ... | 2-oxoglutarate metabolic process female gonad development glutathione metabolic process glyoxylate cycle isocitrate metabolic process NADP metabolic process regulation of phospholipid biosynthetic process regulation of phospholipid catabolic process response to oxidative stress response to steroid hormone tricarboxylic... |
glutaminyl-tRNAGln biosynthesis via transamidation mitochondrial translation | glutamyl-tRNA(Gln) amidotransferase complex; mitochondrion | ATP binding glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity | Homo sapiens | ATP-binding Ligase Mitochondrion Nucleotide-binding Primary mitochondrial disease Protein biosynthesis Reference proteome Transit peptide | MAAPMLRWGC | MAAPMLRWGCRGRRWAFARVDGGSCHRRGAPTGSTSNQIRGESSVAQQPLHTAQKTRKGEHKWAAVVGLEIHAQISSNSKLFSGSQVRFSAPPNSLVSFFDASLPGTLPVLNRRCVEAAVMTGLALNCHINKKSLFDRKHYFYADLPAGYQITQQRLPIAVNGSLIYGVCAGKKQSQVIPKTVRIKQIQLEQDSGKSLHDNLRSQTLIDLNRAGVGLLEVVLEPDMSCGEEAATAVRELQLILQALGTSQANMAEGQLRVDANISVHHPGEPLGVRTEVKNLNSIRFLAKAIDYEIQRQINELENGGEILNETRSFHHKL... | glutaminyl-tRNAGln biosynthesis via transamidation mitochondrial translation glutamyl-tRNA(Gln) amidotransferase complex; mitochondrion ATP binding glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Homo sapiens ATP-binding Ligase Mitochondrion Nucleotide-binding Primary mitochondrial disease Protein biosynthesi... |
intracellular copper ion homeostasis mitochondrial cytochrome c oxidase assembly | mitochondrial inner membrane; mitochondrion; myofibril | copper chaperone activity copper ion binding | Homo sapiens | 3D-structure Chaperone Copper Disease variant Disulfide bond Membrane Metal-binding Mitochondrion Mitochondrion inner membrane Primary mitochondrial disease Reference proteome Transit peptide Transmembrane Transmembrane helix | MAMLVLVPGR | MAMLVLVPGRVMRPLGGQLWRFLPRGLEFWGPAEGTARVLLRQFCARQAEAWRASGRPGYCLGTRPLSTARPPPPWSQKGPGDSTRPSKPGPVSWKSLAITFAIGGALLAGMKHVKKEKAEKLEKERQRHIGKPLLGGPFSLTTHTGERKTDKDYLGQWLLIYFGFTHCPDVCPEELEKMIQVVDEIDSITTLPDLTPLFISIDPERDTKEAIANYVKEFSPKLVGLTGTREEVDQVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKRKGEIAASIATHMRPYRKKS | intracellular copper ion homeostasis mitochondrial cytochrome c oxidase assembly mitochondrial inner membrane; mitochondrion; myofibril copper chaperone activity copper ion binding Homo sapiens 3D-structure Chaperone Copper Disease variant Disulfide bond Membrane Metal-binding Mitochondrion Mitochondrion inner membrane... |
B cell chemotaxis bile acid biosynthetic process cholesterol homeostasis cholesterol metabolic process epithelial cell proliferation intracellular estrogen receptor signaling pathway negative regulation of intracellular estrogen receptor signaling pathway positive regulation of epithelial cell proliferation prostate gl... | endoplasmic reticulum membrane | 24-hydroxycholesterol 7alpha-hydroxylase activity 25-hydroxycholesterol 7alpha-hydroxylase activity 27-hydroxycholesterol 7-alpha-monooxygenase activity heme binding iron ion binding oxysterol 7-alpha-hydroxylase activity | Homo sapiens | Cholesterol metabolism Disease variant Endoplasmic reticulum Heme Hereditary spastic paraplegia Intrahepatic cholestasis Iron Lipid biosynthesis Lipid metabolism Membrane Metal-binding Microsome Monooxygenase Neurodegeneration Oxidoreductase Reference proteome Steroid biosynthesis Steroid metabolism Sterol metabolism T... | MAGEVSAATG | MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQLVIKNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQNLKQVFEPQLLKTTSWDTAELYPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLKFDDKFAYLVSNIPIELLGNVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRD... | B cell chemotaxis bile acid biosynthetic process cholesterol homeostasis cholesterol metabolic process epithelial cell proliferation intracellular estrogen receptor signaling pathway negative regulation of intracellular estrogen receptor signaling pathway positive regulation of epithelial cell proliferation prostate gl... |
positive regulation of gene expression response to nematode type II pneumocyte differentiation | nucleoplasm | hydrolase activity | Homo sapiens | 3D-structure Alternative splicing Hydrolase Reference proteome | MASPSKAVIV | MASPSKAVIVPGNGGGDVTTHGWYGWVKKELEKIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHRVYAIVLVSAYTSDLGDENERASGYFTRPWQWEKIKANCPYIVQFGSTDDPFLPWKEQQEVADRLETKLHKFTDCGHFQNTEFHELITVVKSLLKVPA | positive regulation of gene expression response to nematode type II pneumocyte differentiation nucleoplasm hydrolase activity Homo sapiens 3D-structure Alternative splicing Hydrolase Reference proteome MASPSKAVIV MASPSKAVIVPGNGGGDVTTHGWYGWVKKELEKIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHRVYAIVLVSAYTSDLGDEN... |
macroautophagy membrane fission multivesicular body assembly protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway signal transduction | cytoplasm; cytosol; early endosome membrane; endocytic vesicle; ESCRT-0 complex; intracellular membrane-bounded organelle; nucleoplasm | phosphatidylinositol binding ubiquitin binding | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Endosome Membrane Phosphoprotein Protein transport Reference proteome SH3 domain Transport | MPLFTANPFE | MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKNGTSSNKNKEDEDIAKAIELSLQEQKQQHTETKSLYPSSEIQLNNKVARKVRALYDFEAVEDNELTFKHGEIIIVLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNVIDDDVEEIKKSEPEPVYIDEDKMDRALQVLQSIDPTDSKPDSQDLL... | macroautophagy membrane fission multivesicular body assembly protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway signal transduction cytoplasm; cytosol; early endosome membrane; endocytic vesicle; ESCRT-0 complex; intracellular membrane-boun... |
immune response positive regulation of cell population proliferation positive regulation of isotype switching to IgA isotypes signal transduction | cytoplasm; cytosol; extracellular exosome; extracellular region; extracellular space; membrane; nucleoplasm | cytokine activity receptor ligand activity signaling receptor binding tumor necrosis factor receptor binding | Homo sapiens | 3D-structure Alternative splicing Cleavage on pair of basic residues Cytokine Disulfide bond Glycoprotein Immunity Reference proteome Secreted | MPASSPFLLA | MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKL | immune response positive regulation of cell population proliferation positive regulation of isotype switching to IgA isotypes signal transduction cytoplasm; cytosol; extracellular exosome; extracellular region; extracellular space; membrane; nucleoplasm cytokine activity receptor ligand activity signaling receptor bind... |
10-formyltetrahydrofolate catabolic process biosynthetic process NADPH regeneration one-carbon metabolic process | cytosol; extracellular exosome | aldehyde dehydrogenase (NAD+) activity formyltetrahydrofolate dehydrogenase activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm NADP One-carbon metabolism Oxidoreductase Phosphopantetheine Phosphoprotein Reference proteome | MKIAVIGQSL | MKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWRAKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASAINWTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAVRLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEACEQKLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMILASNFFKGAASSVLELTEAE... | 10-formyltetrahydrofolate catabolic process biosynthetic process NADPH regeneration one-carbon metabolic process cytosol; extracellular exosome aldehyde dehydrogenase (NAD+) activity formyltetrahydrofolate dehydrogenase activity Homo sapiens 3D-structure Acetylation Alternative splicing Cytoplasm NADP One-carbon metabo... |
3'-phosphoadenosine 5'-phosphosulfate metabolic process doxorubicin metabolic process ethanol catabolic process flavonoid metabolic process sulfation xenobiotic metabolic process | cytoplasm; cytosol | aryl sulfotransferase activity sulfotransferase activity | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Reference proteome Transferase | MALHDMEDFT | MALHDMEDFTFDGTKRLSVNYVKGILQPTDTCDIWDKIWNFQAKPDDLLISTYPKAGTTWTQEIVELIQNEGDVEKSKRAPTHQRFPFLEMKIPSLGSGLEQAHAMPSPRILKTHLPFHLLPPSLLEKNCKIIYVARNPKDNMVSYYHFQRMNKALPAPGTWEEYFETFLAGKVCWGSWHEHVKGWWEAKDKHRILYLFYEDMKKNPKHEIQKLAEFIGKKLDDKVLDKIVHYTSFDVMKQNPMANYSSIPAEIMDHSISPFMRKGAVGDWKKHFTVAQNERFDEDYKKKMTDTRLTFHFQF | 3'-phosphoadenosine 5'-phosphosulfate metabolic process doxorubicin metabolic process ethanol catabolic process flavonoid metabolic process sulfation xenobiotic metabolic process cytoplasm; cytosol aryl sulfotransferase activity sulfotransferase activity Homo sapiens 3D-structure Alternative splicing Cytoplasm Referenc... |
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway chemical synaptic transmission G protein-coupled receptor signaling pathway gamma-aminobutyric acid signaling pathway negative regulation of adenylate cyclase activity neuron-glial cell signaling synaptic transmission, GABAergic | cytoplasm; G protein-coupled GABA receptor complex; G protein-coupled receptor heterodimeric complex; GABA receptor complex; neuron projection; plasma membrane; postsynaptic membrane | G protein-coupled GABA receptor activity protein heterodimerization activity transmembrane signaling receptor activity | Homo sapiens | 3D-structure Cell membrane Coiled coil Direct protein sequencing Disease variant Disulfide bond Epilepsy G-protein coupled receptor Glycoprotein Intellectual disability Membrane Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transducer Transmembrane Transmembrane helix | MASPRSSGQP | MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFE... | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway chemical synaptic transmission G protein-coupled receptor signaling pathway gamma-aminobutyric acid signaling pathway negative regulation of adenylate cyclase activity neuron-glial cell signaling synaptic transmission, GABAergic cytoplasm; G prot... |
collagen catabolic process extracellular matrix organization proteolysis reproduction | collagen-containing extracellular matrix; endoplasmic reticulum membrane; extracellular matrix; extracellular space | metalloendopeptidase activity metallopeptidase activity zinc ion binding | Homo sapiens | Alternative splicing Cleavage on pair of basic residues Disulfide bond Endoplasmic reticulum Glycoprotein Hydrolase Immunoglobulin domain Membrane Metal-binding Metalloprotease Protease Reference proteome Signal-anchor Transmembrane Transmembrane helix Zinc Zymogen | MGRGARVPSE | MGRGARVPSEAPGAGVERRWLGAALVALCLLPALVLLARLGAPAVPAWSAAQGDVAALGLSAVPPTRVPGPLAPRRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREVAPEQPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPHGGIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGLHRLYGCLDRLFVCASWARRGFCDARRRLMKRLCPSSCDFCYEFPFPTVATTPPPPRTKTRLVPEGRNVTFR... | collagen catabolic process extracellular matrix organization proteolysis reproduction collagen-containing extracellular matrix; endoplasmic reticulum membrane; extracellular matrix; extracellular space metalloendopeptidase activity metallopeptidase activity zinc ion binding Homo sapiens Alternative splicing Cleavage on... |
diacylglycerol metabolic process fatty acid homeostasis lipid storage long-chain fatty-acyl-CoA metabolic process monoacylglycerol biosynthetic process triglyceride biosynthetic process triglyceride metabolic process very-low-density lipoprotein particle assembly | endoplasmic reticulum membrane; membrane; plasma membrane; specific granule membrane | 2-acylglycerol O-acyltransferase activity acyltransferase activity diacylglycerol O-acyltransferase activity identical protein binding retinol O-fatty-acyltransferase activity | Homo sapiens | 3D-structure Acyltransferase Disease variant Endoplasmic reticulum Lipid metabolism Membrane Phosphoprotein Reference proteome Transferase Transmembrane Transmembrane helix | MGDRGSSRRR | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVGSGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPAAVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHTVSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRII... | diacylglycerol metabolic process fatty acid homeostasis lipid storage long-chain fatty-acyl-CoA metabolic process monoacylglycerol biosynthetic process triglyceride biosynthetic process triglyceride metabolic process very-low-density lipoprotein particle assembly endoplasmic reticulum membrane; membrane; plasma membran... |
cholesterol efflux cholesterol homeostasis cholesterol metabolic process cholesterol storage intestinal cholesterol absorption low-density lipoprotein particle clearance macrophage derived foam cell differentiation very-low-density lipoprotein particle assembly | brush border; endoplasmic reticulum; endoplasmic reticulum membrane | acyltransferase activity cholesterol binding cholesterol O-acyltransferase activity fatty-acyl-CoA binding sterol O-acyltransferase activity | Homo sapiens | 3D-structure Acyltransferase Alternative splicing Cholesterol metabolism Endoplasmic reticulum Lipid metabolism Membrane Oxidation Reference proteome Steroid metabolism Sterol metabolism Thioester bond Transferase Transmembrane Transmembrane helix Ubl conjugation | MEPGGARLRL | MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCV... | cholesterol efflux cholesterol homeostasis cholesterol metabolic process cholesterol storage intestinal cholesterol absorption low-density lipoprotein particle clearance macrophage derived foam cell differentiation very-low-density lipoprotein particle assembly brush border; endoplasmic reticulum; endoplasmic reticulum... |
cell cycle cell division DNA damage response negative regulation by host of viral genome replication positive regulation of DNA-templated transcription, elongation positive regulation of transcription elongation by RNA polymerase II regulation of cyclin-dependent protein serine/threonine kinase activity regulation of s... | cyclin K-CDK12 complex; cyclin K-CDK13 complex; cyclin/CDK positive transcription elongation factor complex; nucleoplasm; nucleus | cyclin-dependent protein serine/threonine kinase activator activity cyclin-dependent protein serine/threonine kinase activity protein kinase binding RNA polymerase II CTD heptapeptide repeat kinase activity | Homo sapiens | 3D-structure Alternative splicing Cell cycle Cell division Cyclin Disease variant Host-virus interaction Intellectual disability Mitosis Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MKENKENSSP | MKENKENSSPSVTSANLDHTKPCWYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLNDVQFGQFGDDPKEEVMVLERILLQTIKFDLQVEHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQFVQDVPVDVLEDICHQILDLYSQGKQQMPHHTPHQLQQPPSLQPTPQVPQVQQSQPSQSSEPSQPQQKDPQQPAQQQQPAQQP... | cell cycle cell division DNA damage response negative regulation by host of viral genome replication positive regulation of DNA-templated transcription, elongation positive regulation of transcription elongation by RNA polymerase II regulation of cyclin-dependent protein serine/threonine kinase activity regulation of s... |
bone morphogenesis cardiac septum morphogenesis negative regulation of retinoic acid receptor signaling pathway outflow tract morphogenesis regulation of ossification regulation of retinoic acid receptor signaling pathway retinoid metabolic process retinol metabolic process roof of mouth development visual perception | endoplasmic reticulum membrane; lipid droplet; photoreceptor outer segment membrane | electron transfer activity NAD-retinol dehydrogenase activity NADP-retinol dehydrogenase activity nucleotide binding | Homo sapiens | Alternative splicing Lipid metabolism Membrane NADP Oxidoreductase Reference proteome Transmembrane Transmembrane helix | MVWKRLGALV | MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKGRT | bone morphogenesis cardiac septum morphogenesis negative regulation of retinoic acid receptor signaling pathway outflow tract morphogenesis regulation of ossification regulation of retinoic acid receptor signaling pathway retinoid metabolic process retinol metabolic process roof of mouth development visual perception e... |
axonogenesis cellular response to organic cyclic compound dendrite development dendritic spine morphogenesis ephrin receptor signaling pathway intracellular signal transduction phosphorylation regulation of actin cytoskeleton organization regulation of actin filament polymerization regulation of axonogenesis regulation... | cytoplasm; cytosol; glutamatergic synapse; plasma membrane; postsynaptic density | ATP binding MAP kinase kinase activity metal ion binding protein serine kinase activity protein serine/threonine kinase activity SH3 domain binding small GTPase binding | Homo sapiens | 3D-structure Allosteric enzyme Alternative splicing ATP-binding Cytoplasm Developmental protein Disease variant Intellectual disability Kinase Magnesium Metal-binding Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase SH3-binding Transferase Ubl conjugation | MSDGLDNEEK | MSDGLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHPSSTKTASEPPLAPPVSEEEDEEEEEEEDENEPPPVIAPRPEHTKSIYTRSVVESIASPAVPNKEVTPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQP... | axonogenesis cellular response to organic cyclic compound dendrite development dendritic spine morphogenesis ephrin receptor signaling pathway intracellular signal transduction phosphorylation regulation of actin cytoskeleton organization regulation of actin filament polymerization regulation of axonogenesis regulation... |
dark adaptation dopamine receptor signaling pathway G protein-coupled receptor signaling pathway intracellular signal transduction light adaption negative regulation of signal transduction nervous system development regulation of calcium ion export across plasma membrane regulation of G protein-coupled receptor signali... | cytoplasm; glutamatergic synapse; neuron projection; plasma membrane; postsynaptic density membrane; presynaptic membrane | GTPase activator activity GTPase activity | Homo sapiens | Alternative splicing Disease variant Membrane Phosphoprotein Reference proteome Sensory transduction Signal transduction inhibitor Vision | MTIRHQGQQY | MTIRHQGQQYRPRMAFLQKIEALVKDMQNPETGVRMQNQRVLVTSVPHAMTGSDVLQWIVQRLWISSLEAQNLGNFIVRYGYIYPLQDPKNLILKPDGSLYRFQTPYFWPTQQWPAEDTDYAIYLAKRNIKKKGILEEYEKENYNFLNQKMNYKWDFVIMQAKEQYRAGKERNKADRYALDCQEKAYWLVHRCPPGMDNVLDYGLDRVTNPNEVKVNQKQTVVAVKKEIMYYQQALMRSTVKSSVSLGGIVKYSEQFSSNDAIMSGCLPSNPWITDDTQFWDLNAKLVEIPTKMRVERWAFNFSELIRDPKGRQSFQYFL... | dark adaptation dopamine receptor signaling pathway G protein-coupled receptor signaling pathway intracellular signal transduction light adaption negative regulation of signal transduction nervous system development regulation of calcium ion export across plasma membrane regulation of G protein-coupled receptor signali... |
fat cell differentiation G1/S transition of mitotic cell cycle negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of pro... | cytoplasm; cytoskeleton; nuclear periphery; nuclear speck; nucleoplasm; nucleus; PML body | DNA-binding transcription factor binding enzyme binding protein domain specific binding SUMO ligase activity SUMO transferase activity transcription cis-regulatory region binding transcription coregulator activity transcription corepressor activity ubiquitin protein ligase binding zinc ion binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Cytoskeleton DNA-binding Host-virus interaction Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger | MADSAELKQM | MADSAELKQMVMSLRVSELQVLLGYAGRNKHGRKHELLTKALHLLKAGCSPAVQMKIKELYRRRFPQKIMTPADLSIPNVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPFYDLLDELIKPTSLASDNSQRFRETCFAFALTPQQVQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPNTIVVSWTAEIGRNYSMAVYLVKQLSSTVLLQRLRAKGIRNPDHSRALIKEKLTADP... | fat cell differentiation G1/S transition of mitotic cell cycle negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of pro... |
DNA-templated transcription negative regulation of androgen receptor signaling pathway negative regulation of DNA-binding transcription factor activity protein sumoylation regulation of transcription by RNA polymerase II | nuclear speck; nucleoplasm; nucleus; PML body | DNA binding RNA polymerase II-specific DNA-binding transcription factor binding SUMO ligase activity SUMO transferase activity transcription coregulator activity ubiquitin protein ligase binding zinc ion binding | Homo sapiens | 3D-structure Alternative splicing DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger | MADFEELRNM | MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSSPVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSR... | DNA-templated transcription negative regulation of androgen receptor signaling pathway negative regulation of DNA-binding transcription factor activity protein sumoylation regulation of transcription by RNA polymerase II nuclear speck; nucleoplasm; nucleus; PML body DNA binding RNA polymerase II-specific DNA-binding tr... |
cytoskeleton-dependent cytokinesis microtubule-based process mitotic cell cycle | centrosome; cleavage furrow; cytosol; dynactin complex; kinetochore; midbody; nucleolus; perinuclear region of cytoplasm; spindle | structural molecule activity | Homo sapiens | Acetylation Alternative splicing Cell cycle Cell division Centromere Chromosome Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Kinetochore Mitosis Reference proteome | MAGLTDLQRL | MAGLTDLQRLQARVEELERWVYGPGGARGSRKVADGLVKVQVALGNISSKRERVKILYKKIEDLIKYLDPEYIDRIAIPDASKLQFILAEEQFILSQVALLEQVNALVPMLDSAHIKAVPEHAARLQRLAQIHIQQQDQCVEITEESKALLEEYNKTTMLLSKQFVQWDELLCQLEAATQVKPAEE | cytoskeleton-dependent cytokinesis microtubule-based process mitotic cell cycle centrosome; cleavage furrow; cytosol; dynactin complex; kinetochore; midbody; nucleolus; perinuclear region of cytoplasm; spindle structural molecule activity Homo sapiens Acetylation Alternative splicing Cell cycle Cell division Centromere... |
carnitine biosynthetic process | cytosol; extracellular exosome; mitochondrion | gamma-butyrobetaine dioxygenase activity identical protein binding iron ion binding zinc ion binding | Homo sapiens | 3D-structure Carnitine biosynthesis Cytoplasm Dioxygenase Iron Metal-binding Oxidoreductase Phosphoprotein Reference proteome Zinc | MACTIQKAEA | MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDVNIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSELQLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHTWQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQKLKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIFDVPVERVQPFYAALKEFVDL... | carnitine biosynthetic process cytosol; extracellular exosome; mitochondrion gamma-butyrobetaine dioxygenase activity identical protein binding iron ion binding zinc ion binding Homo sapiens 3D-structure Carnitine biosynthesis Cytoplasm Dioxygenase Iron Metal-binding Oxidoreductase Phosphoprotein Reference proteome Zin... |
apoptotic process mRNA processing RNA splicing, via transesterification reactions | Cajal body; cytoplasm; nuclear speck; nucleoplasm; nucleus; spliceosomal complex | RNA binding | Homo sapiens | 3D-structure Acetylation Apoptosis Direct protein sequencing mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Spliceosome | MSEDLAKQLA | MSEDLAKQLASYKAQLQQVEAALSGNGENEDLLKLKKDLQEVIELTKDLLSTQPSETLASSDSFASTQPTHSWKVGDKCMAVWSEDGQCYEAEIEEIDEENGTAAITFAGYGNAEVTPLLNLKPVEEGRKAKEDSGNKPMSKKEMIAQQREYKKKKALKKAQRIKELEQEREDQKVKWQQFNNRAYSKNKKGQVKRSIFASPESVTGKVGVGTCGIADKPMTQYQDTSKYNVRHLMPQ | apoptotic process mRNA processing RNA splicing, via transesterification reactions Cajal body; cytoplasm; nuclear speck; nucleoplasm; nucleus; spliceosomal complex RNA binding Homo sapiens 3D-structure Acetylation Apoptosis Direct protein sequencing mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome... |
DNA damage checkpoint signaling DNA damage response DNA repair DNA replication checkpoint signaling mitotic DNA replication checkpoint signaling mitotic intra-S DNA damage checkpoint signaling negative regulation of DNA replication regulation of phosphorylation | nucleolus; nucleoplasm; nucleus; Rad17 RFC-like complex | ATP binding chromatin binding DNA clamp loader activity | Homo sapiens | 3D-structure Alternative splicing ATP-binding Cell cycle DNA damage Nucleotide-binding Nucleus Phosphoprotein Reference proteome | MSKTFLRPKV | MSKTFLRPKVSSTKVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPETQHELAVHKKKIEEVETWLKAQVLERQPKQGGSILLITGPPGCGKTTTLKILSKEHGIQVQEWINPVLPDFQKDDFKGMFNTESSFHMFPYQSQIAVFKEFLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLRKYVRIGRCPLIFIISDSLSGDNNQRLLFPKEIQEECSISNISFNPVAPTIMMKFLNRIVTIEANKNGGKITVPDKT... | DNA damage checkpoint signaling DNA damage response DNA repair DNA replication checkpoint signaling mitotic DNA replication checkpoint signaling mitotic intra-S DNA damage checkpoint signaling negative regulation of DNA replication regulation of phosphorylation nucleolus; nucleoplasm; nucleus; Rad17 RFC-like complex AT... |
proton motive force-driven ATP synthesis proton motive force-driven mitochondrial ATP synthesis | mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrial proton-transporting ATP synthase, stator stalk; mitochondrion | proton transmembrane transporter activity | Homo sapiens | 3D-structure Acetylation Alternative splicing CF(0) Direct protein sequencing Hydrogen ion transport Ion transport Membrane Mitochondrion Mitochondrion inner membrane Reference proteome Transport | MAGRKLALKT | MAGRKLALKTIDWVAFAEIIPQNQKAIASSLKSWNETLTSRLAALPENPPAIDWAYYKANVAKAGLVDDFEKKFNALKVPVPEDKYTAQVDAEEKEDVKSCAEWVSLSKARIVEYEKEMEKMKNLIPFDQMTIEDLNEAFPETKLDKKKYPYWPHQPIENL | proton motive force-driven ATP synthesis proton motive force-driven mitochondrial ATP synthesis mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrial proton-transporting ATP synthase, stator stalk; mitochondrion proton transmembrane transporter activity Homo sapiens 3D-stru... |
defense response to bacterium fertilization fusion of sperm to egg plasma membrane involved in single fertilization killing of cells of another organism metabolic process | acrosomal vesicle; cell surface; extracellular region; sperm flagellum; sperm midpiece; sperm plasma membrane | lysozyme activity | Homo sapiens | Antimicrobial Bacteriolytic enzyme Cell projection Cilium Disulfide bond Fertilization Flagellum Glycosidase Hydrolase Reference proteome Secreted Signal | MTKALLIYLV | MTKALLIYLVSSFLALNQASLISRCDLAQVLQLEDLDGFEGYSLSDWLCLAFVESKFNISKINENADGSFDYGLFQINSHYWCNDYKSYSENLCHVDCQDLLNPNLLAGIHCAKRIVSGARGMNNWVEWRLHCSGRPLFYWLTGCRLR | defense response to bacterium fertilization fusion of sperm to egg plasma membrane involved in single fertilization killing of cells of another organism metabolic process acrosomal vesicle; cell surface; extracellular region; sperm flagellum; sperm midpiece; sperm plasma membrane lysozyme activity Homo sapiens Antimicr... |
epithelial cilium movement involved in extracellular fluid movement sperm capacitation | cytoplasm; cytoskeleton; cytosol; extracellular region; motile cilium; nucleoplasm; nucleus; sperm fibrous sheath | calcium ion binding enzyme binding SH3 domain binding | Homo sapiens | Alternative splicing Calcium Cell projection Cilium Cytoplasm Cytoskeleton Direct protein sequencing Flagellum Metal-binding Nucleus Phosphoprotein Reference proteome | MISSKPRLVV | MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVKQFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPF... | epithelial cilium movement involved in extracellular fluid movement sperm capacitation cytoplasm; cytoskeleton; cytosol; extracellular region; motile cilium; nucleoplasm; nucleus; sperm fibrous sheath calcium ion binding enzyme binding SH3 domain binding Homo sapiens Alternative splicing Calcium Cell projection Cilium ... |
acrosome reaction blastocyst hatching protein localization single fertilization transmembrane receptor protein serine/threonine kinase signaling pathway | acrosomal vesicle; cytoplasm; nucleus; sperm fibrous sheath; sperm midpiece; sperm principal piece | protein kinase A binding | Homo sapiens | Cytoplasmic vesicle Direct protein sequencing Phosphoprotein Reference proteome | MSEKVDWLQS | MSEKVDWLQSQNGVCKVDVYSPGDNQAQDWKMDTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPGESFGGETSNSGDPHKGFSVDYYNTTTKGTPERLHFEMTHKEIPCQGPRAQLGNGSSVDEVSFYANRLTNLVIAMARKEINEKIDGSENKCVYQSLYMGNEPTPTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRVSGSSQSPPNLKYKSTLKIKESTKERQGPDDKPPSKKSFFYKEVFESRNGDYAREGGRFFPRERKRFRGQERPDDFTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATILLKK... | acrosome reaction blastocyst hatching protein localization single fertilization transmembrane receptor protein serine/threonine kinase signaling pathway acrosomal vesicle; cytoplasm; nucleus; sperm fibrous sheath; sperm midpiece; sperm principal piece protein kinase A binding Homo sapiens Cytoplasmic vesicle Direct pro... |
snRNA transcription by RNA polymerase II snRNA transcription by RNA polymerase III transcription initiation at RNA polymerase III promoter | nuclear body; nucleolus; nucleoplasm; nucleus | RNA polymerase II general transcription initiation factor activity RNA polymerase III general transcription initiation factor activity | Homo sapiens | 3D-structure Alternative splicing Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MLSRLQELRK | MLSRLQELRKEEETLLRLKAALHDQLNRLKVEELALQSMISSRRGDEMLSSHTVPEQSHDMLVHVDNEASINQTTLELSTKSHVTEEEEEEEEEESDS | snRNA transcription by RNA polymerase II snRNA transcription by RNA polymerase III transcription initiation at RNA polymerase III promoter nuclear body; nucleolus; nucleoplasm; nucleus RNA polymerase II general transcription initiation factor activity RNA polymerase III general transcription initiation factor activity ... |
cluster assembly cell redox homeostasis intracellular iron ion homeostasis iron-sulfur cluster assembly negative regulation of cardiac muscle hypertrophy protein maturation by iron-sulfur cluster transfer regulation of the force of heart contraction | cell cortex; cytoplasm; cytosol; dendrite; iron-sulfur cluster assembly complex; nucleus; Z disc | identical protein binding iron-sulfur cluster binding metal ion binding protein kinase C binding RNA binding | Homo sapiens | 3D-structure Acetylation Cytoplasm Direct protein sequencing Iron Iron-sulfur Metal-binding Phosphoprotein Reference proteome Repeat | MAAGAAEAAV | MAAGAAEAAVAAVEEVGSAGQFEELLRLKAKSLLVVHFWAPWAPQCAQMNEVMAELAKELPQVSFVKLEAEGVPEVSEKYEISSVPTFLFFKNSQKIDRLDGAHAPELTKKVQRHASSGSFLPSANEHLKEDLNLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSFDIFSDEEVRQGLKAYSSWPTYPQLYVSGELIGGLDIIKELEASEELDTICPKAPKLEERLKVLTNKASVMLFMKGNKQEAKCGFSKQILEILNSTGVEYETFDILEDEEVRQGLKAYSNWPTYPQLYVKGELVGGLDIVKE... | cluster assembly cell redox homeostasis intracellular iron ion homeostasis iron-sulfur cluster assembly negative regulation of cardiac muscle hypertrophy protein maturation by iron-sulfur cluster transfer regulation of the force of heart contraction cell cortex; cytoplasm; cytosol; dendrite; iron-sulfur cluster assemb... |
epidermis development epithelial cell differentiation intermediate filament organization | cytoskeleton; cytosol; extracellular space; intermediate filament | structural molecule activity | Homo sapiens | Coiled coil Intermediate filament Keratin Reference proteome | MSYSCCLPSL | MSYSCCLPSLGCRTSCSSRPCVPPSCHGYTLPGACNIPANVSNCNWFCEGSFNGSEKETMQFLNDRLASYLEKVRQLERDNAELEKLIQERSQQQEPLLCPSYQSYFKTIEELQQKILCAKAENARLVVNIDNAKLASDDFRSKYQTEQSLRLLVESDINSIRRILDELTLCKSDLESQVESLREELICLKKNHEEEVNTLRSQLGDRLNVEVDTAPTVDLNQVLNETRSQYEALVEINRREVEQWFATQTEELNKQVVSSSEQLQSCQAEIIELRRTVNALEIELQAQHNLRDSLENTLTESEAHYSSQLSQVQSLITN... | epidermis development epithelial cell differentiation intermediate filament organization cytoskeleton; cytosol; extracellular space; intermediate filament structural molecule activity Homo sapiens Coiled coil Intermediate filament Keratin Reference proteome MSYSCCLPSL MSYSCCLPSLGCRTSCSSRPCVPPSCHGYTLPGACNIPANVSNCNWFCEGS... |
epithelial cell differentiation intermediate filament organization regulation of keratinocyte differentiation | cytosol; extracellular exosome; intermediate filament cytoskeleton; keratin filament | structural constituent of skin epidermis | Homo sapiens | Alternative splicing Coiled coil Intermediate filament Keratin Reference proteome | MATQTCTPTF | MATQTCTPTFSTGSIKGLCGTAGGISRVSSIRSVGSCRVPSLAGAAGYISSARSGLSGLGSCLPGSYLSSECHTSGFVGSGGWFCEGSFNGSEKETMQFLNDRLANYLEKVRQLERENAELESRIQEWYEFQIPYICPDYQSYFKTIEDFQQKILLTKSENARLVLQIDNAKLAADDFRTKYETELSLRQLVEADINGLRRILDELTLCKADLEAQVESLKEELMCLKKNHEEEVSVLRCQLGDRLNVEVDAAPPVDLNKILEDMRCQYEALVENNRRDVEAWFNTQTEELNQQVVSSSEQLQCCQTEIIELRRTVNALE... | epithelial cell differentiation intermediate filament organization regulation of keratinocyte differentiation cytosol; extracellular exosome; intermediate filament cytoskeleton; keratin filament structural constituent of skin epidermis Homo sapiens Alternative splicing Coiled coil Intermediate filament Keratin Referenc... |
epithelial cell differentiation intermediate filament organization | cytoskeleton; cytosol; extracellular exosome; intermediate filament | structural molecule activity | Homo sapiens | Coiled coil Intermediate filament Keratin Reference proteome | MTSFYSTSSC | MTSFYSTSSCPLGCTMAPGARNVFVSPIDVGCQPVAEANAASMCLLANVAHANRVRVGSTPLGRPSLCLPPTSHTACPLPGTCHIPGNIGICGAYGKNTLNGHEKETMKFLNDRLANYLEKVRQLEQENAELETTLLERSKCHESTVCPDYQSYFRTIEELQQKILCSKAENARLIVQIDNAKLAADDFRIKLESERSLHQLVEADKCGTQKLLDDATLAKADLEAQQESLKEEQLSLKSNHEQEVKILRSQLGEKFRIELDIEPTIDLNRVLGEMRAQYEAMVETNHQDVEQWFQAQSEGISLQAMSCSEELQCCQSEI... | epithelial cell differentiation intermediate filament organization cytoskeleton; cytosol; extracellular exosome; intermediate filament structural molecule activity Homo sapiens Coiled coil Intermediate filament Keratin Reference proteome MTSFYSTSSC MTSFYSTSSCPLGCTMAPGARNVFVSPIDVGCQPVAEANAASMCLLANVAHANRVRVGSTPLGRPSLCLPP... |
epithelial cell differentiation intermediate filament organization | cytoskeleton; cytosol; extracellular exosome; intermediate filament | structural molecule activity | Homo sapiens | Coiled coil Intermediate filament Keratin Reference proteome | MTSSYSSSSC | MTSSYSSSSCPLGCTMAPGARNVSVSPIDIGCQPGAEANIAPMCLLANVAHANRVRVGSTPLGRPSLCLPPTCHTACPLPGTCHIPGNIGICGAYGENTLNGHEKETMQFLNDRLANYLEKVRQLEQENAELEATLLERSKCHESTVCPDYQSYFHTIEELQQKILCSKAENARLIVQIDNAKLAADDFRIKLESERSLRQLVEADKCGTQKLLDDATLAKADLEAQQESLKEEQLSLKSNHEQEVKILRSQLGEKLRIELDIEPTIDLNRVLGEMRAQYEAMLETNRQDVEQWFQAQSEGISLQDMSCSEELQCCQSEI... | epithelial cell differentiation intermediate filament organization cytoskeleton; cytosol; extracellular exosome; intermediate filament structural molecule activity Homo sapiens Coiled coil Intermediate filament Keratin Reference proteome MTSSYSSSSC MTSSYSSSSCPLGCTMAPGARNVSVSPIDIGCQPGAEANIAPMCLLANVAHANRVRVGSTPLGRPSLCLPP... |
maturation of LSU-rRNA osteoblast differentiation regulation of apoptotic process regulation of cellular senescence regulation of protein localization | 90S preribosome; chromosome; cytosolic large ribosomal subunit; membrane; nucleolus | cadherin binding mRNA 3'-UTR binding mRNA 5'-UTR binding RNA binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Coiled coil Direct protein sequencing Isopeptide bond Nucleus Phosphoprotein Reference proteome Ubl conjugation | MEDSASASLS | MEDSASASLSSAAATGTSTSTPAAPTARKQLDKEQVRKAVDALLTHCKSRKNNYGLLLNENESLFLMVVLWKIPSKELRVRLTLPHSIRSDSEDICLFTKDEPNSTPEKTEQFYRKLLNKHGIKTVSQIISLQTLKKEYKSYEAKLRLLSSFDFFLTDARIRRLLPSLIGRHFYQRKKVPVSVNLLSKNLSREINDCIGGTVLNISKSGSCSAIRIGHVGMQIEHIIENIVAVTKGLSEKLPEKWESVKLLFVKTEKSAALPIFSSFVSNWDEATKRSLLNKKKKEARRKRRERNFEKQKERKKKRQQARKTASVLSKDD... | maturation of LSU-rRNA osteoblast differentiation regulation of apoptotic process regulation of cellular senescence regulation of protein localization 90S preribosome; chromosome; cytosolic large ribosomal subunit; membrane; nucleolus cadherin binding mRNA 3'-UTR binding mRNA 5'-UTR binding RNA binding Homo sapiens 3D-... |
cell-cell adhesion | cell surface; collagen-containing extracellular matrix; cytoplasm; cytosol; extracellular space; nucleus; plasma membrane; synapse; vesicle | acetylcholine receptor activity calcium channel activity calcium ion binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding phosphatidylserine binding phospholipase A2 inhibitor activity phospholipid binding protease binding virion binding | Homo sapiens | Annexin Reference proteome Repeat | MSVTGGKMAP | MSVTGGKMAPSLTQEILSHLGLASKTAAWGTLGTLRTFLNFSVDKDAQRLLRAITGQGVDRSAIVDVLTNRSREQRQLISRNFQERTQQDLMKSLQAALSGNLERIVMALLQPTAQFDAQELRTALKASDSAVDVAIEILATRTPPQLQECLAVYKHNFQVEAVDDITSETSGILQDLLLALAKGGRDSYSGIIDYNLAEQDVQALQRAEGPSREETWVPVFTQRNPEHLIRVFDQYQRSTGQELEEAVQNRFHGDAQVALLGLASVIKNTPLYFADKLHQALQETEPNYQVLIRILISRCETDLLSIRAEFRKKFGKSL... | cell-cell adhesion cell surface; collagen-containing extracellular matrix; cytoplasm; cytosol; extracellular space; nucleus; plasma membrane; synapse; vesicle acetylcholine receptor activity calcium channel activity calcium ion binding calcium-dependent phospholipid binding phosphatidylinositol-4,5-bisphosphate binding... |
ATP metabolic process proteolysis proteolysis involved in protein catabolic process | cytosol; endopeptidase Clp complex; mitochondrial endopeptidase Clp complex; mitochondrial inner membrane; mitochondrial matrix; mitochondrial nucleoid; mitochondrion; nucleoplasm | ATP binding ATP hydrolysis activity ATP-dependent protein folding chaperone peptidase activator activity protein dimerization activity unfolded protein binding zinc ion binding | Homo sapiens | Acetylation ATP-binding Chaperone Disease variant Metal-binding Mitochondrion Mitochondrion nucleoid Nucleotide-binding Phosphoprotein Reference proteome Transit peptide Zinc | MPSCGACTCG | MPSCGACTCGAAAVRLITSSLASAQRGISGGRIHMSVLGRLGTFETQILQRAPLRSFTETPAYFASKDGISKDGSGDGNKKSASEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELEIRRREDEYRFTKLLQIAGISPHGNALGASMQQQVNQQIPQEKRGGEVLDSSHDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCT... | ATP metabolic process proteolysis proteolysis involved in protein catabolic process cytosol; endopeptidase Clp complex; mitochondrial endopeptidase Clp complex; mitochondrial inner membrane; mitochondrial matrix; mitochondrial nucleoid; mitochondrion; nucleoplasm ATP binding ATP hydrolysis activity ATP-dependent protei... |
modulation of chemical synaptic transmission neuron migration positive regulation of axon extension positive regulation of dendrite morphogenesis positive regulation of dendritic spine development positive regulation of GTPase activity protein autophosphorylation protein phosphorylation regulation of cilium assembly re... | centrosome; ciliary basal body; ciliary tip; dendrite cytoplasm; dendritic growth cone; glutamatergic synapse; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynaptic density, intracellular component | ATP binding cyclin-dependent protein serine/threonine kinase activity kinase activity protein kinase activity protein serine kinase activity protein serine/threonine kinase activity small GTPase binding | Homo sapiens | 3D-structure Alternative splicing ATP-binding Cell projection Chromosomal rearrangement Cytoplasm Cytoskeleton Disease variant Epilepsy Intellectual disability Kinase Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase | MKIPNIGNVM | MKIPNIGNVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTLKQENIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPPEKVKSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQSLERRYLGILNSVLLDLMKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPSRSAKRKPYHVES... | modulation of chemical synaptic transmission neuron migration positive regulation of axon extension positive regulation of dendrite morphogenesis positive regulation of dendritic spine development positive regulation of GTPase activity protein autophosphorylation protein phosphorylation regulation of cilium assembly re... |
cardiac muscle thin filament assembly | extracellular exosome; I band; stress fiber; Z disc | actin filament binding cytoskeletal protein binding filamin binding structural constituent of muscle tropomyosin binding | Homo sapiens | 3D-structure Actin-binding Alternative splicing Cytoplasm Methylation Reference proteome Repeat SH3 domain | MRVPVFEDIK | MRVPVFEDIKDETEEEKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDAD... | cardiac muscle thin filament assembly extracellular exosome; I band; stress fiber; Z disc actin filament binding cytoskeletal protein binding filamin binding structural constituent of muscle tropomyosin binding Homo sapiens 3D-structure Actin-binding Alternative splicing Cytoplasm Methylation Reference proteome Repeat ... |
cellular response to amino acid stimulus lactation negative regulation of cell population proliferation negative regulation of Notch signaling pathway nervous system development Notch signaling pathway positive regulation of apoptotic process positive regulation of dendritic spine development positive regulation of fil... | apical dendrite; dendritic spine; perikaryon; perinuclear region of cytoplasm; plasma membrane; postsynaptic density | metal ion binding translation factor activity, non-nucleic acid binding ubiquitin protein ligase activity ubiquitin-protein transferase activity | Homo sapiens | Alternative splicing Cell membrane Cell projection Cytoplasm Lipoprotein Membrane Metal-binding Myristate Notch signaling pathway Reference proteome Repeat Synapse Transferase Translation regulation Tumor suppressor Ubl conjugation pathway Zinc Zinc-finger | MGNNFSSIPS | MGNNFSSIPSLPRGNPSRAPRGHPQNLKDSIGGPFPVTSHRCHHKQKHCPAVLPSGGLPATPLLFHPHTKGSQILMDLSHKAVKRQASFCNAITFSNRPVLIYEQVRLKITKKQCCWSGALRLGFTSKDPSRIHPDSLPKYACPDLVSQSGFWAKALPEEFANEGNIIAFWVDKKGRVFHRINDSAVMLFFSGVRTADPLWALVDVYGLTRGVQLLDSELVLPDCLRPRSFTALRRPSLRREADDARLSVSLCDLNVPGADGDEAAPAAGCPIPQNSLNSQHSRALPAQLDGDLRFHALRAGAHVRILDEQTVARVEHGR... | cellular response to amino acid stimulus lactation negative regulation of cell population proliferation negative regulation of Notch signaling pathway nervous system development Notch signaling pathway positive regulation of apoptotic process positive regulation of dendritic spine development positive regulation of fil... |
positive regulation of DNA-templated transcription regulation of cholesterol biosynthetic process | cytoplasm; cytosol; extracellular exosome; nucleoplasm; nucleus | phospholipid binding vitamin E binding | Homo sapiens | 3D-structure Activator Alternative splicing Cytoplasm Lipid-binding Nucleus Reference proteome Transcription Transcription regulation Transport | MSGRVGDLSP | MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQKSEAMLRKHVEFRKQKDIDNIISWQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDLLRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEENYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQVPVEYGGTMTDPDGNPKCKSKINYGGDIPRKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPGCVLRWQFMSDGADVGFGIFL... | positive regulation of DNA-templated transcription regulation of cholesterol biosynthetic process cytoplasm; cytosol; extracellular exosome; nucleoplasm; nucleus phospholipid binding vitamin E binding Homo sapiens 3D-structure Activator Alternative splicing Cytoplasm Lipid-binding Nucleus Reference proteome Transcripti... |
cellular response to hypoxia decidualization embryo implantation endoplasmic reticulum unfolded protein response intracellular calcium ion homeostasis negative regulation of gene expression negative regulation of multicellular organism growth regulation of hormone biosynthetic process regulation of store-operated calci... | endoplasmic reticulum; endoplasmic reticulum lumen; extracellular space; Golgi apparatus; perinuclear region of cytoplasm | enzyme binding heme binding hormone activity protein homodimerization activity | Homo sapiens | 3D-structure Disulfide bond Glycoprotein Hormone Phosphoprotein Reference proteome Secreted Signal | MCAERLGQFM | MCAERLGQFMTLALVLATFDPARGTDATNPPEGPQDRSSQQKGRLSLQNTAEIQHCLVNAGDVGCGVFECFENNSCEIRGLHGICMTFLHNAGKFDAQGKSFIKDALKCKAHALRHRFGCISRKCPAIREMVSQLQRECYLKHDLCAAAQENTRVIVEMIHFKDLLLHEPYVDLVNLLLTCGEEVKEAITHSVQVQCEQNWGSLCSILSFCTSAIQKPPTAPPERQPQVDRTKLSRAHHGEAGHHLPEPSSRETGRGAKGERGSKSHPNAHARGRVGGLGAQGPSGSSEWEDEQSEYSDIRR | cellular response to hypoxia decidualization embryo implantation endoplasmic reticulum unfolded protein response intracellular calcium ion homeostasis negative regulation of gene expression negative regulation of multicellular organism growth regulation of hormone biosynthetic process regulation of store-operated calci... |
cholesterol biosynthetic process | endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; nuclear inner membrane; plasma membrane; receptor complex | delta14-sterol reductase activity NADP binding | Homo sapiens | Alternative splicing Cholesterol biosynthesis Cholesterol metabolism Endoplasmic reticulum Lipid biosynthesis Lipid metabolism Membrane Microsome NADP Oxidoreductase Reference proteome Steroid biosynthesis Steroid metabolism Sterol biosynthesis Sterol metabolism Transmembrane Transmembrane helix | MAPTQGPRAP | MAPTQGPRAPLEFGGPLGAAALLLLLPATMFHLLLAARSGPARLLGPPASLPGLEVLWSPRALLLWLAWLGLQAALYLLPARKVAEGQELKDKSRLRYPINGFQALVLTALLVGLGMSAGLPLGALPEMLLPLAFVATLTAFIFSLFLYMKAQVAPVSALAPGGNSGNPIYDFFLGRELNPRICFFDFKYFCELRPGLIGWVLINLALLMKEAELRGSPSLAMWLVNGFQLLYVGDALWHEEAVLTTMDITHDGFGFMLAFGDMAWVPFTYSLQAQFLLHHPQPLGLPMASVICLINATGYYIFRGANSQKNTFRKNPSD... | cholesterol biosynthetic process endoplasmic reticulum; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; nuclear inner membrane; plasma membrane; receptor complex delta14-sterol reductase activity NADP binding Homo sapiens Alternative splicing Cholesterol biosynthesis Cholesterol metabolism End... |
cell cycle cell division DNA damage response DNA repair-dependent chromatin remodeling double-strand break repair double-strand break repair via nonhomologous end joining epigenetic regulation of gene expression interstrand cross-link repair isotype switching negative regulation of transcription elongation by RNA polym... | chromosome, telomeric region; cytosol; midbody; nucleoplasm; nucleus; site of double-strand break; ubiquitin ligase complex | chromatin binding histone binding identical protein binding protein homodimerization activity ubiquitin binding ubiquitin protein ligase activity ubiquitin protein ligase binding ubiquitin-protein transferase activity zinc ion binding | Homo sapiens | 3D-structure Alternative splicing Cell cycle Cell division Chromatin regulator Chromosome Cytoplasm Direct protein sequencing DNA damage DNA repair Host-virus interaction Metal-binding Mitosis Nucleus Phosphoprotein Reference proteome Telomere Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger | MGEPGFFVTG | MGEPGFFVTGDRAGGRSWCLRRVGMSAGWLLLEDGCEVTVGRGFGVTYQLVSKICPLMISRNHCVLKQNPEGQWTIMDNKSLNGVWLNRARLEPLRVYSIHQGDYIQLGVPLENKENAEYEYEVTEEDWETIYPCLSPKNDQMIEKNKELRTKRKFSLDELAGPGAEGPSNLKSKINKVSCESGQPVKSQGKGEVASTPSDNLDPKLTALEPSKTTGAPIYPGFPKVTEVHHEQKASNSSASQRSLQMFKVTMSRILRLKIQMQEKHEAVMNVKKQTQKGNSKKVVQMEQELQDLQSQLCAEQAQQQARVEQLEKTFQEE... | cell cycle cell division DNA damage response DNA repair-dependent chromatin remodeling double-strand break repair double-strand break repair via nonhomologous end joining epigenetic regulation of gene expression interstrand cross-link repair isotype switching negative regulation of transcription elongation by RNA polym... |
adult locomotory behavior chemical synaptic transmission protein secretion regulation of dopamine secretion regulation of neurotransmitter secretion synapse organization synaptic vesicle endocytosis | axon terminus; centrosome; cytoplasm; extracellular exosome; neuronal cell body; perinuclear region of cytoplasm; spindle | cuprous ion binding | Homo sapiens | Cytoplasm Cytoskeleton Phosphoprotein Reference proteome Repeat | MDVFKKGFSI | MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTKEQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAEEAQSGGD | adult locomotory behavior chemical synaptic transmission protein secretion regulation of dopamine secretion regulation of neurotransmitter secretion synapse organization synaptic vesicle endocytosis axon terminus; centrosome; cytoplasm; extracellular exosome; neuronal cell body; perinuclear region of cytoplasm; spindle... |
cGMP catabolic process negative regulation of cardiac muscle contraction negative regulation of T cell proliferation oocyte development positive regulation of cardiac muscle hypertrophy positive regulation of oocyte development regulation of nitric oxide mediated signal transduction relaxation of cardiac muscle signal ... | cytosol | 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity cGMP binding metal ion binding | Homo sapiens | 3D-structure Allosteric enzyme Alternative splicing cGMP cGMP-binding Hydrolase Metal-binding Nucleotide-binding Phosphoprotein Reference proteome Repeat Zinc | MERAGPSFGQ | MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLY... | cGMP catabolic process negative regulation of cardiac muscle contraction negative regulation of T cell proliferation oocyte development positive regulation of cardiac muscle hypertrophy positive regulation of oocyte development regulation of nitric oxide mediated signal transduction relaxation of cardiac muscle signal ... |
apoptotic chromosome condensation apoptotic DNA fragmentation DNA catabolic process negative regulation of apoptotic DNA fragmentation | chromatin; cytosol; nucleolus; nucleoplasm; nucleus; protein-containing complex | disordered domain specific binding DNA binding DNA endonuclease activity DNA nuclease activity enzyme binding identical protein binding protein domain specific binding | Homo sapiens | 3D-structure Alternative splicing Apoptosis Cytoplasm Hydrolase Nuclease Nucleus Reference proteome | MLQKPKSVKL | MLQKPKSVKLRALRSPRKFGVAGRSCQEVLRKGCLRFQLPERGSRLCLYEDGTELTEDYFPSVPDNAELVLLTLGQAWQGYVSDIRRFLSAFHEPQVGLIQAAQQLLCDEQAPQRQRLLADLLHNVSQNIAAETRAEDPPWFEGLESRFQSKSGYLRYSCESRIRSYLREVSSYPSTVGAEAQEEFLRVLGSMCQRLRSMQYNGSYFDRGAKGGSRLCTPEGWFSCQGPFDMDSCLSRHSINPYSNRESRILFSTWNLDHIIEKKRTIIPTLVEAIKEQDGREVDWEYFYGLLFTSENLKLVHIVCHKKTTHKLNCDPSR... | apoptotic chromosome condensation apoptotic DNA fragmentation DNA catabolic process negative regulation of apoptotic DNA fragmentation chromatin; cytosol; nucleolus; nucleoplasm; nucleus; protein-containing complex disordered domain specific binding DNA binding DNA endonuclease activity DNA nuclease activity enzyme bin... |
cell adhesion cell-cell signaling signal transduction | extracellular matrix; extracellular space; nucleus | heparin binding integrin binding | Homo sapiens | Alternative splicing Cell adhesion Direct protein sequencing Disulfide bond Reference proteome Secreted Signal | MRGTPKTHLL | MRGTPKTHLLAFSLLCLLSKVRTQLCPTPCTCPWPPPRCPLGVPLVLDGCGCCRVCARRLGEPCDQLHVCDASQGLVCQPGAGPGGRGALCLLAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPCPPSRGRSPQNSAF | cell adhesion cell-cell signaling signal transduction extracellular matrix; extracellular space; nucleus heparin binding integrin binding Homo sapiens Alternative splicing Cell adhesion Direct protein sequencing Disulfide bond Reference proteome Secreted Signal MRGTPKTHLL MRGTPKTHLLAFSLLCLLSKVRTQLCPTPCTCPWPPPRCPLGVPLVL... |
face development fibroblast migration in utero embryonic development platelet-derived growth factor receptor signaling pathway respiratory system process skeletal system morphogenesis smooth muscle tissue development vasculature development | cytoplasm | DNA binding zinc ion binding | Homo sapiens | 3D-structure Acetylation Cytoplasm Metal-binding Phosphoprotein Reference proteome Ubl conjugation pathway Zinc Zinc-finger | MAQETNQTPG | MAQETNQTPGPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQQNSGRMSPMGTASGSNSPTSDSASVQRADTSLNNCEGAAGSTSEKSRNVPVAALPVTQQMTEMSISREDKITTPKTEVSEPVVTQPSPSVSQPSTSQSEEKAPELPKPKKNRCFMCRKKVGLTGFDCRCGNLFCGLHRYSDKHNCPYDYKAEAAAKIRKENPVVVAEKIQRI | face development fibroblast migration in utero embryonic development platelet-derived growth factor receptor signaling pathway respiratory system process skeletal system morphogenesis smooth muscle tissue development vasculature development cytoplasm DNA binding zinc ion binding Homo sapiens 3D-structure Acetylation Cy... |
G protein-coupled receptor signaling pathway negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway | cytoplasm; nucleus; plasma membrane; trans-Golgi network | GTPase activator activity GTPase activity | Homo sapiens | Alternative splicing Cytoplasm Glycoprotein Lipoprotein Membrane Nucleus Palmitate Phosphoprotein Reference proteome Signal transduction inhibitor Ubl conjugation | MPQLSQDNQE | MPQLSQDNQECLQKHFSRPSIWTQFLPLFRAQRYNTDIHQITENEGDLRAVPDIKSFPPAQLPDSPAAPKLFGLLSSPLSSLARFFSHLLRRPPPEAPRRRLDFSPLLPALPAARLSRGHEELPGRLSLLLGAALALPGRPSGGRPLRPPHPVAKPREEDATAGQSSPMPQMGSERMEMRKRQMPAAQDTPGAAPGQPGAGSRGSNACCFCWCCCCSCSCLTVRNQEDQRPTIASHELRADLPTWEESPAPTLEEVNAWAQSFDKLMVTPAGRNAFREFLRTEFSEENMLFWMACEELKKEANKNIIEEKARIIYEDYIS... | G protein-coupled receptor signaling pathway negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway cytoplasm; nucleus; plasma membrane; trans-Golgi network GTPase activator activity GTPase activity Homo sapiens Alternative splicing Cytoplasm Glycoprotein Lipoprotein Membr... |
(R)-carnitine transmembrane transport (R)-carnitine transport carnitine transmembrane transport carnitine transport positive regulation of intestinal epithelial structure maintenance quaternary ammonium group transport response to symbiotic bacterium response to tumor necrosis factor response to type II interferon sodi... | apical plasma membrane; basal plasma membrane; brush border membrane; cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; plasma membrane | (R)-carnitine transmembrane transporter activity amino-acid betaine transmembrane transporter activity ATP binding carnitine transmembrane transporter activity PDZ domain binding quaternary ammonium group transmembrane transporter activity symporter activity xenobiotic transmembrane transporter activity | Homo sapiens | Alternative splicing ATP-binding Cell membrane Disease variant Endoplasmic reticulum Glycoprotein Ion transport Membrane Nucleotide-binding Phosphoprotein Reference proteome Sodium Sodium transport Symport Transmembrane Transmembrane helix Transport | MRDYDEVTAF | MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVPDAANLSSAWRNHTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEWNLVCEDDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKANGIVVPSTIFDPSELQD... | (R)-carnitine transmembrane transport (R)-carnitine transport carnitine transmembrane transport carnitine transport positive regulation of intestinal epithelial structure maintenance quaternary ammonium group transport response to symbiotic bacterium response to tumor necrosis factor response to type II interferon sodi... |
cGMP catabolic process cGMP metabolic process negative regulation of neural precursor cell proliferation positive regulation of cardiac muscle hypertrophy positive regulation of long-term synaptic potentiation signal transduction | cytosol; endoplasmic reticulum; Golgi apparatus; nucleoplasm; perikaryon; perinuclear region of cytoplasm; plasma membrane; ruffle membrane; sarcolemma | 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity identical protein binding metal ion binding | Homo sapiens | 3D-structure Alternative splicing Cell membrane Cell projection cGMP Cytoplasm Endoplasmic reticulum Golgi apparatus Hydrolase Magnesium Membrane Metal-binding Phosphoprotein Reference proteome Zinc | MGSGSSSYRP | MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCV... | cGMP catabolic process cGMP metabolic process negative regulation of neural precursor cell proliferation positive regulation of cardiac muscle hypertrophy positive regulation of long-term synaptic potentiation signal transduction cytosol; endoplasmic reticulum; Golgi apparatus; nucleoplasm; perikaryon; perinuclear regi... |
chloride transport detection of light stimulus involved in visual perception monoatomic ion transmembrane transport regulation of calcium ion transport transepithelial chloride transport visual perception | basal plasma membrane; basolateral plasma membrane; chloride channel complex; cytosol; membrane; plasma membrane | bicarbonate transmembrane transporter activity chloride channel activity identical protein binding intracellular calcium activated chloride channel activity | Homo sapiens | 3D-structure Alternative splicing Calcium Cell membrane Chloride Chloride channel Disease variant Ion channel Ion transport Membrane Phosphoprotein Reference proteome Retinitis pigmentosa Sensory transduction Transmembrane Transmembrane helix Transport Vision | MTITYTSQVA | MTITYTSQVANARLGSFSRLLLCWRGSIYKLLYGEFLIFLLCYYIIRFIYRLALTEEQQLMFEKLTLYCDSYIQLIPISFVLGFYVTLVVTRWWNQYENLPWPDRLMSLVSGFVEGKDEQGRLLRRTLIRYANLGNVLILRSVSTAVYKRFPSAQHLVQAGFMTPAEHKQLEKLSLPHNMFWVPWVWFANLSMKAWLGGRIRDPILLQSLLNEMNTLRTQCGHLYAYDWISIPLVYTQVVTVAVYSFFLTCLVGRQFLNPAKAYPGHELDLVVPVFTFLQFFFYVGWLKVAEQLINPFGEDDDDFETNWIVDRNLQVSLL... | chloride transport detection of light stimulus involved in visual perception monoatomic ion transmembrane transport regulation of calcium ion transport transepithelial chloride transport visual perception basal plasma membrane; basolateral plasma membrane; chloride channel complex; cytosol; membrane; plasma membrane bi... |
anatomical structure morphogenesis angiogenesis animal organ morphogenesis cell differentiation cell population proliferation cell-cell signaling chondrocyte development endochondral ossification ERK1 and ERK2 cascade fibroblast growth factor receptor signaling pathway intramembranous ossification lung development posi... | cytoplasm; extracellular region; extracellular space; nucleolus | growth factor activity type 1 fibroblast growth factor receptor binding type 2 fibroblast growth factor receptor binding | Homo sapiens | 3D-structure Disulfide bond Glycoprotein Growth factor Reference proteome Secreted Signal | MYSAPSACTC | MYSAPSACTCLCLHFLLLCFQVQVLVAEENVDFRIHVENQTRARDDVSRKQLRLYQLYSRTSGKHIQVLGRRISARGEDGDKYAQLLVETDTFGSQVRIKGKETEFYLCMNRKGKLVGKPDGTSKECVFIEKVLENNYTALMSAKYSGWYVGFTKKGRPRKGPKTRENQQDVHFMKRYPKGQPELQKPFKYTTVTKRSRRIRPTHPA | anatomical structure morphogenesis angiogenesis animal organ morphogenesis cell differentiation cell population proliferation cell-cell signaling chondrocyte development endochondral ossification ERK1 and ERK2 cascade fibroblast growth factor receptor signaling pathway intramembranous ossification lung development posi... |
SRP-dependent cotranslational protein targeting to membrane | cytosol; endoplasmic reticulum; signal recognition particle; signal recognition particle, endoplasmic reticulum targeting | 7S RNA binding RNA binding signal recognition particle binding TPR domain binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Direct protein sequencing Disease variant Endoplasmic reticulum Isopeptide bond Phosphoprotein Reference proteome Repeat Ribonucleoprotein Signal recognition particle TPR repeat Ubl conjugation | MASGGSGGVS | MASGGSGGVSVPALWSEVNRYGQNGDFTRALKTVNKILQINKDDVTALHCKVVCLIQNGSFKEALNVINTHTKVLANNSLSFEKAYCEYRLNRIENALKTIESANQQTDKLKELYGQVLYRLERYDECLAVYRDLVRNSQDDYDEERKTNLSAVVAAQSNWEKVVPENLGLQEGTHELCYNTACALIGQGQLNQAMKILQKAEDLCRRSLSEDTDGTEEDPQAELAIIHGQMAYILQLQGRTEEALQLYNQIIKLKPTDVGLLAVIANNIITINKDQNVFDSKKKVKLTNAEGVEFKLSKKQLQAIEFNKALLAMYTNQA... | SRP-dependent cotranslational protein targeting to membrane cytosol; endoplasmic reticulum; signal recognition particle; signal recognition particle, endoplasmic reticulum targeting 7S RNA binding RNA binding signal recognition particle binding TPR domain binding Homo sapiens 3D-structure Acetylation Alternative splici... |
apoptotic mitochondrial changes mitotic cell cycle mitotic cytokinesis positive regulation of protein kinase activity regulation of cell population proliferation | centrosome; cytoplasm; membrane; midbody; mitochondrion; plasma membrane; spindle | protein kinase binding | Homo sapiens | 3D-structure Alternative splicing Apoptosis Cell cycle Cell division Cytoplasm Cytoskeleton Membrane Mitochondrion Mitosis Reference proteome Signal Transmembrane Transmembrane helix | MLAGAGRPGL | MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWLVEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSALMEQRLFWKFEGAVVCVALIFACLVIIRQRQLDRKALEKVRKQIESI | apoptotic mitochondrial changes mitotic cell cycle mitotic cytokinesis positive regulation of protein kinase activity regulation of cell population proliferation centrosome; cytoplasm; membrane; midbody; mitochondrion; plasma membrane; spindle protein kinase binding Homo sapiens 3D-structure Alternative splicing Apopto... |
immune response negative regulation of microglial cell activation negative regulation of peptidase activity positive regulation of myelination | cytoplasmic vesicle; endoplasmic reticulum; endosome; extracellular space; Golgi apparatus; late endosome; lysosome; multivesicular body | cysteine-type endopeptidase inhibitor activity endopeptidase inhibitor activity peptidase inhibitor activity protein homodimerization activity | Homo sapiens | 3D-structure Cytoplasm Disulfide bond Glycoprotein Protease inhibitor Reference proteome Secreted Signal Thiol protease inhibitor | MRAAGTLLAF | MRAAGTLLAFCCLVLSTTGGPSPDTCSQDLNSRVKPGFPKTIKTNDPGVLQAARYSVEKFNNCTNDMFLFKESRITRALVQIVKGLKYMLEVEIGRTTCKKNQHLRLDDCDFQTNHTLKQTLSCYSEVWVVPWLQHFEVPVLRCH | immune response negative regulation of microglial cell activation negative regulation of peptidase activity positive regulation of myelination cytoplasmic vesicle; endoplasmic reticulum; endosome; extracellular space; Golgi apparatus; late endosome; lysosome; multivesicular body cysteine-type endopeptidase inhibitor ac... |
behavioral response to cocaine cell communication cellular response to light stimulus circadian rhythm endocytosis imaginal disc growth locomotor rhythm negative regulation of apoptotic process negative regulation of protein phosphorylation negative regulation of smoothened signaling pathway phosphorylation positive re... | cell body; cytoplasm; cytosol; nucleoplasm; nucleus | ATP binding protein serine kinase activity protein serine/threonine kinase activity | Drosophila melanogaster | ATP-binding Biological rhythms Cytoplasm Kinase Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase | MELRVGNKYR | MELRVGNKYRLGRKIGSGSFGDIYLGTTINTGEEVAIKLECIRTKHPQLHIESKFYKTMQGGIGIPRIIWCGSEGDYNVMVMELLGPSLEDLFNFCSRRFSLKTVLLLADQMISRIDYIHSRDFIHRDIKPDNFLMGLGKKGNLVYIIDFGLAKKFRDARSLKHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGALPWQGLKAANKRQKYERISEKKLSTSIVVLCKGFPSEFVNYLNFCRQMHFDQRPDYCHLRKLFRNLFHRLGFTYDYVFDWNLLKFGGPRNPQAIQQAQDGADGQAGHDAV... | behavioral response to cocaine cell communication cellular response to light stimulus circadian rhythm endocytosis imaginal disc growth locomotor rhythm negative regulation of apoptotic process negative regulation of protein phosphorylation negative regulation of smoothened signaling pathway phosphorylation positive re... |
apoptotic process involved in development engulfment of apoptotic cell establishment of mitotic spindle orientation left/right axis specification positive regulation of apoptotic process involved in development positive regulation of distal tip cell migration positive regulation of engulfment of apoptotic cell programm... | cytoplasmic side of plasma membrane; phagocytic vesicle | clathrin adaptor activity scavenger receptor binding | Caenorhabditis elegans | Apoptosis Cytoplasm Developmental protein Phagocytosis Reference proteome | MAKDIYKTFK | MAKDIYKTFKRSVSGIVGGNNINGEGSSSPSTSAPQVKYRGGTGRTWIHPPDYLINGHVEYVARFLGCVETPKANGSDVAREAIHAIRFQRDLKRSEQTRETAKLQKVEIRISIDNVIIADIKTKAPMYTFPLGRISFCADDKDDKRMFSFIARAEGASGKPSCYAFTSEKLAEDITLTIGEAFDLAYKRFLDKNRTSLENQKQIYILKKKIVELETENQVLIERLAEALRANSKADYENTGPPIYPGLGPPALPLSPMPQGPPPNIPPSSIYSMPRANDLPPTEMAPTLPQISTSSNGASPSVSPASTSPSGPAPSIPP... | apoptotic process involved in development engulfment of apoptotic cell establishment of mitotic spindle orientation left/right axis specification positive regulation of apoptotic process involved in development positive regulation of distal tip cell migration positive regulation of engulfment of apoptotic cell programm... |
antibacterial innate immune response defense response to Gram-positive bacterium digestion killing of cells of another organism metabolic process | extracellular region; late endosome lumen; lysosomal lumen; recycling endosome lumen | lysozyme activity | Caenorhabditis elegans | Antibiotic Antimicrobial Bacteriolytic enzyme Digestion Disulfide bond Endosome Glycosidase Hydrolase Lysosome Reference proteome Secreted Signal | MFVKSLVFLT | MFVKSLVFLTIAVAYASADCLHCICMRESGCKPIGCNMDVGSLSCGYYQIKLPYYEDCGQPTKKSGETTEAAWKRCANDLSCATTCVENYYNRYKSQCAGTGQGACEVMARNHNGGPQGCKHSGTLGYWNGIKSCCGCS | antibacterial innate immune response defense response to Gram-positive bacterium digestion killing of cells of another organism metabolic process extracellular region; late endosome lumen; lysosomal lumen; recycling endosome lumen lysozyme activity Caenorhabditis elegansAntibiotic Antimicrobial Bacteriolytic enzyme Dig... |
embryonic morphogenesis oocyte development protein urmylation spermatogenesis translation tRNA thio-modification tRNA wobble position uridine thiolation tRNA wobble uridine modification vulval development | cytosol; cytosolic tRNA wobble base thiouridylase complex | nucleotidyltransferase activity sulfurtransferase activity tRNA binding | Caenorhabditis elegans | Cytoplasm Reference proteome RNA-binding Transferase tRNA processing tRNA-binding | MEKRRGPPPC | MEKRRGPPPCQSGSGCSNPAKIRKAKDGAQLCGPCFSRNFEDDVHEAIVNNKLFKRGERVAIGASGGKDSTVLAYVMKTLNDRHDYGLDLQLLSIDEGIKGYRDDSLLAVEKNRVEYGLPLTILSYRDLYGWTMDDIVAKIGKKNNCTFCGVFRRQALDRGAFKIGATKLVTGHNADDMAETLLMNVLRGDIARLERCTNIVTGEEGDLPRAKPLKYCFERDIVMYARTNQLEYFYTECIYAPNAYRGYARKYVRDLEKVHPRAILDLIRSGEKVSVKKEVEMPTLKICERCGYMTSQKLCKACLLIEGLNTGNTDLGVR... | embryonic morphogenesis oocyte development protein urmylation spermatogenesis translation tRNA thio-modification tRNA wobble position uridine thiolation tRNA wobble uridine modification vulval development cytosol; cytosolic tRNA wobble base thiouridylase complex nucleotidyltransferase activity sulfurtransferase activit... |
egg-laying behavior proteolysis | cilium; dendrite; perikaryon | metallocarboxypeptidase activity zinc ion binding | Caenorhabditis elegans | Carboxypeptidase Cell projection Hydrolase Metal-binding Metalloprotease Protease Reference proteome Zinc | MPSDSDDVAA | MPSDSDDVAAVKQPWSQLIVDISNFLSEHPQSKTSQALLPSCNGVWSDEEKLELIEAFGHKKQSHLTKSGVKAVLAAFEGDRTQPDVIFLCRLLHLIFSHFSSENDRKKEKYIVKCDVIATLTRITRKRIIMTLDVTDESSIDHNLDEVLWKLLHKIGLKDPRVSLKVRMGGLISPMCKLFIQKDTLPELFLPFFIKISRSPRNGQAIGRYEGFMTRLLVKIKALDASDQTSQVLLLDKHLQLLFFTMKNKRTRTQLLRENICKYLLEVLRRHLASSSNSRPTRLLSSLFGTFDKSLSAAHTEVVIGTIAILRLLSNFKK... | egg-laying behavior proteolysis cilium; dendrite; perikaryon metallocarboxypeptidase activity zinc ion binding Caenorhabditis elegansCarboxypeptidase Cell projection Hydrolase Metal-binding Metalloprotease Protease Reference proteome Zinc MPSDSDDVAA MPSDSDDVAAVKQPWSQLIVDISNFLSEHPQSKTSQALLPSCNGVWSDEEKLELIEAFGHKKQSHLTKSG... |
cell division chromatin remodeling DNA synthesis involved in double-strand break repair via homologous recombination dorsal appendage formation double-strand break repair double-strand break repair via homologous recombination double-strand break repair via synthesis-dependent strand annealing intracellular mRNA locali... | nucleus | ATP binding ATP hydrolysis activity ATP-dependent chromatin remodeler activity DNA binding DNA translocase activity helicase activity | Drosophila melanogaster | ATP-binding Cell cycle Cell division DNA damage DNA repair DNA-binding Helicase Hydrolase Meiosis Mitosis Nucleotide-binding Nucleus Phosphoprotein Reference proteome | MRRSLAPSQR | MRRSLAPSQRGPLRPESRHSFTPPLLKKNKRSCQQELEREQELDRRRLGALRDASNTSELPLPIRFTANSEYELAIAKVLARKFKVPMDNYVPDYGGKRVLGVRRCISRRPLHDPMACNALVLFHPPAYTEHERMGMDPTKVLVHVVVDPLLSNILRPHQREGVRFMYECVEGKRGNFNGCIMADEMGLGKTLQCVTLVWTLLRQGPECKPTINKAIVVSPSSLVKNWEKEFTKWLHGRLLCLPMEGGTKENTIRALEQFSMTSARLGTPVLLISYETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALMGLKTKR... | cell division chromatin remodeling DNA synthesis involved in double-strand break repair via homologous recombination dorsal appendage formation double-strand break repair double-strand break repair via homologous recombination double-strand break repair via synthesis-dependent strand annealing intracellular mRNA locali... |
adenylate cyclase-modulating G protein-coupled receptor signaling pathway determination of adult lifespan G protein-coupled receptor signaling pathway serotonin receptor signaling pathway | heterotrimeric G-protein complex | G protein-coupled receptor binding G-protein beta/gamma-subunit complex binding GTP binding GTPase activity metal ion binding | Caenorhabditis elegans | Alternative splicing GTP-binding Magnesium Metal-binding Nucleotide-binding Reference proteome Transducer | MSAADMARKN | MSAADMARKNSLINRQLEKEKIDSKKMLKILLLGGPECGKSTIFKQMKIIHMNGFSDLDYVNFRYLIYSNIMQSMDQLLEAAEFFHFPPDDSPSIRRALNHYKSYKVRYSTSEVELNRELADSLSKLYNAEFIKSVLNRKNELKLLDSAVYFLDDIDRISAHEYKPTEMDVLRARVPTTGITEIEFPFKQASLRMVDVGGQRSEQRKWIHCFDNVNGVLFIAAISGYNLYDEDEENRKDDGTPTKTNRLRYSMELFKRIANHQCFSKKTAMILFLNKIDIFKEKIGKYPLTTCFKNYKGVNAFEPACKYVTDRFSRLVSG... | adenylate cyclase-modulating G protein-coupled receptor signaling pathway determination of adult lifespan G protein-coupled receptor signaling pathway serotonin receptor signaling pathway heterotrimeric G-protein complex G protein-coupled receptor binding G-protein beta/gamma-subunit complex binding GTP binding GTPase ... |
acetylcholine transport choline transport neuromuscular synaptic transmission neurotransmitter uptake positive regulation of locomotion sodium ion transmembrane transport | postsynaptic membrane | acetylcholine transmembrane transporter activity neurotransmitter:sodium symporter activity PDZ domain binding | Caenorhabditis elegans | Cell membrane Glycoprotein Membrane Neurotransmitter transport Postsynaptic cell membrane Reference proteome Symport Synapse Transmembrane Transmembrane helix Transport | MSVSSNDPEQ | MSVSSNDPEQRNGRGMASGNNVDMSLYPPFIKQLDAKLPDYTREGDIEYPFEEITGVGDENRIRGNWSNKSDYLLAVIGFTAGVGSFWKFPFLVFQHGGAAFLVPYLCMLCLASLPMFFMEMVLGQFSSSAAISVWKVVPLFKGIGFAQVTISGFFAVFFNIISAWTLFYLINSFSFSIPWSNCANSWSGENCTLGTRIQCKEMNGTLLVNGSCIVEHASSNETTVIPLHDLGSIPSLKYFHNDVLMLSKGVDDFGTLNWYLGLCVLACWIAVFLCLFQGVKSSGKVVYVAVIVPFIILTVLLTRLLTLDGSLAAVFYFL... | acetylcholine transport choline transport neuromuscular synaptic transmission neurotransmitter uptake positive regulation of locomotion sodium ion transmembrane transport postsynaptic membrane acetylcholine transmembrane transporter activity neurotransmitter:sodium symporter activity PDZ domain binding Caenorhabditis e... |
autophagy border follicle cell migration clathrin-dependent endocytosis involved in vitellogenesis dsRNA transport endocytosis endosomal transport endosomal vesicle fusion endosome to lysosome transport endosome to lysosome transport via multivesicular body sorting pathway exosomal secretion phagosome-lysosome fusion p... | autophagosome membrane; cell cortex; cell projection; early endosome membrane; late endosome; late endosome membrane; lysosomal membrane; lysosome; neuronal cell body; perikaryon; phagocytic vesicle; plasma membrane; presynapse; synapse; vesicle | GTP binding GTPase activity protein-containing complex binding | Drosophila melanogaster | Autophagy Cell projection Cytoplasmic vesicle Endosome GTP-binding Hydrolase Lipoprotein Lysosome Membrane Nucleotide-binding Phosphoprotein Prenylation Protein transport Reference proteome Synapse Transport | MSGRKKSLLK | MSGRKKSLLKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDRVVTMQIWDTAGQERFQSLGVAFYRGADCCVLVYDVTAPNSFKNLDSWRDEFLIQASPRDPDHFPFVVLGNKVDLDNRQVSTRRAQQWCQSKNDIPYYETSAKEGINVEMAFQVIAKNALELEAEAEVINDFPDQITLGSQNNRPGNPDNCQC | autophagy border follicle cell migration clathrin-dependent endocytosis involved in vitellogenesis dsRNA transport endocytosis endosomal transport endosomal vesicle fusion endosome to lysosome transport endosome to lysosome transport via multivesicular body sorting pathway exosomal secretion phagosome-lysosome fusion p... |
nitric oxide transport phosphatidylinositol dephosphorylation vasodilation in another organism | extracellular space | heme binding iron ion binding phosphatase activity | Cimex lectularius | 3D-structure Allergen Direct protein sequencing Heme Iron Metal-binding Reference proteome Secreted Signal Transport Vasoactive Vasodilator | MKLLLSAGAA | MKLLLSAGAALAFVLGLCAAGSPPAQLSVHTVSWNSGHERAPTNLEELLGLNSGETPDVIAVAVQGFGFQTDKPQQGPACVKNFQSLLTSKGYTKLKNTITETMGLTVYCLEKHLDQNTLKNETIIVTVDDQKKSGGIVTSFTIYNKRFSFTTSRMSDEDVTSTNTKYAYDTRLDYSKKDDPSDFLFWIGDLNVRVETNATHAKSLVDQNNIDGLMAFDQLKKAKEQKLFDGWTEPQVTFKPTYKFKPNTDEYDLSATPSWTDRALYKSGTGKTIQPLSYNSLTNYKQTEHRPVLAKFRVTL | nitric oxide transport phosphatidylinositol dephosphorylation vasodilation in another organism extracellular space heme binding iron ion binding phosphatase activity Cimex lectularius 3D-structure Allergen Direct protein sequencing Heme Iron Metal-binding Reference proteome Secreted Signal Transport Vasoactive Vasodil... |
neuropeptide signaling pathway pheromone biosynthetic process response to pheromone | extracellular region | neuropeptide hormone activity | Agrotis ipsilon | Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Neuropeptide Pheromone response Secreted Signal | MYGAVLPGLF | MYGAVLPGLFFIFISCVVASSNDVKDGGADRGAHSDRGGMWFGPRIGKRSLRMATEDNRQAFFKLLEAADALKYYYDQLPYEMQADEPEARVTKKVIFTPKLGRSLSYEDKMFDNVEFTPRLGRRLADDTPATPADQEMYRPDPEQIDSRTKYFSPRLGRTMNFSPRLGRELAYEMLPSKVRVVRSTNKTQST | neuropeptide signaling pathway pheromone biosynthetic process response to pheromone extracellular region neuropeptide hormone activity Agrotis ipsilon Amidation Cleavage on pair of basic residues Direct protein sequencing Hormone Neuropeptide Pheromone response Secreted Signal MYGAVLPGLF MYGAVLPGLFFIFISCVVASSNDVKDGGADR... |
programmed cell death proteolysis | early endosome; early phagosome; extracellular region; lysosome; phagocytic vesicle | aspartic-type endopeptidase activity | Dictyostelium discoideum | Aspartyl protease Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Lysosome Protease Reference proteome Secreted Signal Zymogen | MKLLILTLFL | MKLLILTLFLATIVLAQALTVPLNFHQASRESRRRVPQKWSNRLSALNAGTTIPISDFEDAQYYGAITIGTPGQAFKVVFDTGSSNLWIPSKKCPITVVACDLHNKYNSGASSTYVANGTDFTIQYGSGAMSGFVSQDSVTVGSLTVKDQLFAEATAEPGIAFDFAKFDGILGLAFQSISVNSIPPVFYNMLSQGLVSSTLFSFWLSRTPGANGGELSFGSIDNTKYTGDITYVPLTNETYWEFVMDDFAIDGQSAGFCGTTCHAICDSGTSLIAGPMADITALNEKLGAVILNGEGVFSDCSVINTLPNVTITVAGREF... | programmed cell death proteolysis early endosome; early phagosome; extracellular region; lysosome; phagocytic vesicle aspartic-type endopeptidase activity Dictyostelium discoideum Aspartyl protease Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Lysosome Protease Reference proteome Secreted Signal Zymog... |
endocytosis endosome organization endosome to lysosome transport | apical plasma membrane; cell cortex; early endosome; endosome membrane; late endosome | metal ion binding phosphatidylinositol binding | Drosophila melanogaster | Cell membrane Cytoplasm Endocytosis Endosome Membrane Metal-binding Reference proteome Zinc Zinc-finger | MVDRLVNSEA | MVDRLVNSEANTRRIASVENCFGSSGVPLAMQGRVLVGEGVLTKMCRKRPKSRQFFLFNDILVYGNIVIGKKKYNKQHIMPLEEVSLESIADNQTYRNGWYIRTTTKSFVVFAATSTEKQEWMAHINKCVEDLLRKSGKKPVENHAAVWVPDTDASVCMHCKKTQFTFIQRRHHCRNCGAVVCAGCSAKKFLLPQQSTKALRVCDACYERLKHVPSSLGSGEDSAAATGAASGNKLNTTAGDSSNDEDSDEETASPGGESHDEPRFYGDNSVLSAVEDSSTITSPSSATTGSLEAPQVTPSVQSSPAAVATTGSHC | endocytosis endosome organization endosome to lysosome transport apical plasma membrane; cell cortex; early endosome; endosome membrane; late endosome metal ion binding phosphatidylinositol binding Drosophila melanogaster Cell membrane Cytoplasm Endocytosis Endosome Membrane Metal-binding Reference proteome Zinc Zinc-f... |
pattern specification process regulation of DNA-templated transcription segment specification | nucleus | chromatin binding DNA binding | Drosophila melanogaster | Developmental protein DNA-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MEELSKQPPP | MEELSKQPPPPPLTQPPPPSSSVSIEEPLPNGKGGGAVVVNSIAKLPEEELLGSVTMHNCPGTRASARVIQKMKQDQTRPMTPPPSEREPNKKEEKAAQKTPSQLKTGSGKTTWTNVERNCFFDALNEFGKDFEAVANCINAKLKRRNANSDYSFKTKDQVRQHYYQTHHKICKYVRFSEELKKPAQELYTLINYGEMRRKLQFLTEKHFMKLKQLVYQGQITVRCKGKNIRIKTPSCKALRRLNQLDDSLEDIRLPSKVEVLVTPANMEAFGRVQSLAQNPRGRIIVPLHKKLISFIKTFEYKWRSANQRLHEEKSAYF... | pattern specification process regulation of DNA-templated transcription segment specification nucleus chromatin binding DNA binding Drosophila melanogaster Developmental protein DNA-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation MEELSKQPPP MEELSKQPPPPPLTQPPPPSSSVSIEEPLPNGKGGGAV... |
female meiotic nuclear division homologous chromosome pairing at meiosis positive regulation of meiotic DNA double-strand break formation protein sumoylation reciprocal meiotic recombination | central element; chromosome; recombination nodule; site of double-strand break; synaptonemal complex | metal ion binding SUMO transferase activity | Drosophila melanogaster | Chromosome Meiosis Metal-binding Reference proteome Zinc Zinc-finger | MAKSQAGQTV | MAKSQAGQTVEPEASKLWIHCNSCCALFCDKKHTFFLLACHHVFCERCVKVSAGRTPSDAPIFECSTCRRSVRGRQLTNSMPNHFKQLFHPEPFTIGNDFVETFQRGNHRHFDKYKERKELEMDKLFKDIEVAKSVCQKRFLEAQMLRVERKKLMQRSRYIKAEVANRKAEMHRMAQAYRSRSLTSQSSSSAQRSARGRPRGRGTATQSSSRRRSTESAKRQQITSFIHPPNNSFDL | female meiotic nuclear division homologous chromosome pairing at meiosis positive regulation of meiotic DNA double-strand break formation protein sumoylation reciprocal meiotic recombination central element; chromosome; recombination nodule; site of double-strand break; synaptonemal complex metal ion binding SUMO trans... |
defense response to Gram-negative bacterium dorsal appendage formation global gene silencing by mRNA cleavage heterochromatin formation maintenance of pole plasm mRNA location mitotic chromosome condensation oocyte karyosome formation oocyte maturation oogenesis P granule assembly pole cell development pole cell format... | cytoplasm; P granule | piRNA binding RNA endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters | Drosophila melanogaster | 3D-structure Acetylation Alternative splicing Cytoplasm Developmental protein Differentiation Methylation Oogenesis Reference proteome RNA-binding RNA-mediated gene silencing Translation regulation | MNLPPNPVIA | MNLPPNPVIARGRGRGRKPNNVEANRGFAPSLGQKSDPSHSEGNQASGGNGGGGDAQVGPSIEKSSLSAVQMHKSEGDPRGSVRGRRLITDLVYSRPPGMTSKKGVVGTHITVQANYFKVLKRPNWTIYQYRVDFTPDVEATRLRRSFLYEHKGILGGYIFDGTNMFCINQFKAVQDSPYVLELVTKSRAGENIEIKIKAVGSVQSTDAEQFQVLNLILRRAMEGLDLKLVSRYYYDPQAKINLENFRMQLWPGYQTSIRQHENDILLCSEICHKVMRTETLYNILSDAIRDSDDYQSTFKRAVMGMVILTDYNNKTYRI... | defense response to Gram-negative bacterium dorsal appendage formation global gene silencing by mRNA cleavage heterochromatin formation maintenance of pole plasm mRNA location mitotic chromosome condensation oocyte karyosome formation oocyte maturation oogenesis P granule assembly pole cell development pole cell format... |
positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein polyubiquitination ubiquitin-dependent protein catabolic process | cytoplasm; nucleus; ubiquitin ligase complex | ubiquitin conjugating enzyme binding ubiquitin protein ligase activity ubiquitin-protein transferase activity zinc ion binding | Drosophila melanogaster | Coiled coil Metal-binding Nucleus Reference proteome Repeat Transferase Ubl conjugation pathway Zinc Zinc-finger | MDSDIEMDME | MDSDIEMDMESDNDGEYDDDYDYYNTGEDCDVERLDPKRADPEYFEYECLTVEDIEKLLNERVEKLNTILQITPSLAKVLLLEHQWNNVAVVEKYRQDANALLVTARIKPPSVAVTDTASTSAAAASAQLLRLGSSGYKTTASATPQYRSQMCPVCASSQLGDKFYSLACGHSFCKDCWTIYFETQIFQGISTQIGCMAQMCNVRVPEDLVLTLVTRPVMRDKYQQFAFKDYVKSHPELRFCPGPNCQIIVQSSEISAKRAICKACHTGFCFRCGMDYHAPTDCQVIKKWLTKCADDSETANYISAHTKDCPKCHICIEK... | positive regulation of proteasomal ubiquitin-dependent protein catabolic process protein polyubiquitination ubiquitin-dependent protein catabolic process cytoplasm; nucleus; ubiquitin ligase complex ubiquitin conjugating enzyme binding ubiquitin protein ligase activity ubiquitin-protein transferase activity zinc ion bi... |
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