Biological Process stringlengths 7 1.01k | Cellular Component stringlengths 6 867 | Molecular Function stringlengths 11 871 | Organism stringlengths 8 73 | Keywords stringlengths 1 810 | Sequence 10 stringlengths 5 10 | Sequence stringlengths 5 1.02k | Combined stringlengths 136 3.91k |
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calcium ion transmembrane transport intracellular calcium ion homeostasis mammary gland epithelium development manganese ion transport positive regulation of calcium ion import protein localization to plasma membrane | basolateral plasma membrane; cytoplasmic side of plasma membrane; cytoplasmic vesicle; endoplasmic reticulum; Golgi membrane; perinuclear region of cytoplasm; plasma membrane; trans-Golgi network membrane | ATP binding ATP hydrolysis activity metal ion binding P-type calcium transporter activity P-type manganese transporter activity | Homo sapiens | Alternative splicing ATP-binding Calcium Calcium transport Cell membrane Golgi apparatus Ion transport Magnesium Membrane Metal-binding Nucleotide-binding Phosphoprotein Reference proteome Translocase Transmembrane Transmembrane helix Transport | MVEGRVSEFL | MVEGRVSEFLKKLGFSGGGRQYQALEKDEEEALIDEQSELKAIEKEKKVTALPPKEACKCQKEDLARAFCVDLHTGLSEFSVTQRRLAHGWNEFVADNSEPVWKKYLDQFKNPLILLLLGSALVSVLTKEYEDAVSIATAVLVVVTVAFIQEYRSEKSLEELTKLVPPECNCLREGKLQHLLARELVPGDVVSLSIGDRIPADIRLTEVTDLLVDESSFTGEAEPCSKTDSPLTGGGDLTTLSNIVFMGTLVQYGRGQGVVIGTGESSQFGEVFKMMQAEETPKTPLQKSMDRLGKQLTLFSFGIIGLIMLIGWSQGKQL... | calcium ion transmembrane transport intracellular calcium ion homeostasis mammary gland epithelium development manganese ion transport positive regulation of calcium ion import protein localization to plasma membrane basolateral plasma membrane; cytoplasmic side of plasma membrane; cytoplasmic vesicle; endoplasmic reti... |
actin cytoskeleton organization chaperone-mediated protein folding chorio-allantoic fusion chorion development extracellular matrix organization intermediate filament organization negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of DNA-templated transcription... | cytoplasm; cytosol; membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; Z disc | ATPase activator activity DNA binding heat shock protein binding Hsp70 protein binding identical protein binding protein folding chaperone protein-folding chaperone binding unfolded protein binding | Homo sapiens | 3D-structure Alternative splicing Chaperone Cytoplasm Direct protein sequencing Disease variant Limb-girdle muscular dystrophy Methylation Nucleus Phosphoprotein Reference proteome | MVDYYEVLGV | MVDYYEVLGVQRHASPEDIKKAYRKLALKWHPDKNPENKEEAERKFKQVAEAYEVLSDAKKRDIYDKYGKEGLNGGGGGGSHFDSPFEFGFTFRNPDDVFREFFGGRDPFSFDFFEDPFEDFFGNRRGPRGSRSRGTGSFFSAFSGFPSFGSGFSSFDTGFTSFGSLGHGGLTSFSSTSFGGSGMGNFKSISTSTKMVNGRKITTKRIVENGQERVEVEEDGQLKSLTINGVADDDALAEERMRRGQNALPAQPAGLRPPKPPRPASLLRHAPHCLSEEEGEQDRPRAPGPWDPLASAAGLKEGGKRKKQKQREESKKKK... | actin cytoskeleton organization chaperone-mediated protein folding chorio-allantoic fusion chorion development extracellular matrix organization intermediate filament organization negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of DNA-templated transcription... |
carbohydrate metabolic process D-xylose metabolic process generation of precursor metabolites and energy glucuronate catabolic process to xylulose 5-phosphate phosphorylation xylulose catabolic process xylulose metabolic process | cytosol | ATP binding xylulokinase activity | Homo sapiens | 3D-structure Alternative splicing ATP-binding Carbohydrate metabolism Kinase Nucleotide-binding Reference proteome Transferase Xylose metabolism | MAEHAPRRCC | MAEHAPRRCCLGWDFSTQQVKVVAVDAELNVFYEESVHFDRDLPEFGTQGGVHVHKDGLTVTSPVLMWVQALDIILEKMKASGFDFSQVLALSGAGQQHGSIYWKAGAQQALTSLSPDLRLHQQLQDCFSISDCPVWMDSSTTAQCRQLEAAVGGAQALSCLTGSRAYERFTGNQIAKIYQQNPEAYSHTERISLVSSFAASLFLGSYSPIDYSDGSGMNLLQIQDKVWSQACLGACAPHLEEKLSPPVPSCSVVGAISSYYVQRYGFPPGCKVVAFTGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQEPMPALEGHI... | carbohydrate metabolic process D-xylose metabolic process generation of precursor metabolites and energy glucuronate catabolic process to xylulose 5-phosphate phosphorylation xylulose catabolic process xylulose metabolic process cytosol ATP binding xylulokinase activity Homo sapiens 3D-structure Alternative splicing AT... |
brown fat cell differentiation peroxisome fission peroxisome membrane biogenesis peroxisome organization regulation of peroxisome size signal transduction | peroxisomal membrane; peroxisome; protein-containing complex | protein homodimerization activity | Homo sapiens | Alternative splicing Membrane Peroxisome Peroxisome biogenesis Reference proteome Transmembrane Transmembrane helix | MDAFTRFTNQ | MDAFTRFTNQTQGRDRLFRATQYTCMLLRYLLEPKAGKEKVVMKLKKLESSVSTGRKWFRLGNVVHAIQATEQSIHATDLVPRLCLTLANLNRVIYFICDTILWVRSVGLTSGINKEKWRTRAAHHYYYSLLLSLVRDLYEISLQMKRVTCDRAKKEKSASQDPLWFSVAEEETEWLQSFLLLLFRSLKQHPPLLLDTVKNLCDILNPLDQLGIYKSNPGIIGLGGLVSSIAGMITVAYPQMKLKTR | brown fat cell differentiation peroxisome fission peroxisome membrane biogenesis peroxisome organization regulation of peroxisome size signal transduction peroxisomal membrane; peroxisome; protein-containing complex protein homodimerization activity Homo sapiens Alternative splicing Membrane Peroxisome Peroxisome bioge... |
endosome organization negative regulation of cell population proliferation negative regulation of TOR signaling regulation of TOR signaling | cytoplasm; early endosome; membrane; plasma membrane | small GTPase binding | Homo sapiens | Acetylation Cell membrane Cytoplasm Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Tumor suppressor | MYAPGGAGLP | MYAPGGAGLPGGRRRRSPGGSALPKQPERSLASALPGALSITALCTALAEPAWLHIHGGTCSRQELGVSDVLGYVHPDLLKDFCMNPQTVLLLRVIAAFCFLGILCSLSAFLLDVFGPKHPALKITRRYAFAHILTVLQCATVIGFSYWASELILAQQQQHKKYHGSQVYVTFAVSFYLVAGAGGASILATAANLLRHYPTEEEEQALELLSEMEENEPYPAEYEVINQFQPPPAYTP | endosome organization negative regulation of cell population proliferation negative regulation of TOR signaling regulation of TOR signaling cytoplasm; early endosome; membrane; plasma membrane small GTPase binding Homo sapiens Acetylation Cell membrane Cytoplasm Membrane Phosphoprotein Reference proteome Transmembrane ... |
release of cytochrome c from mitochondria | cytosol; extracellular exosome | gamma-glutamylcyclotransferase activity protein homodimerization activity | Homo sapiens | 3D-structure Alternative splicing Lyase Phosphoprotein Reference proteome | MANSGCKDVT | MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKTSQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQEGVKSGMYVVIEVKVATQEGKEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDIIKKGETQTL | release of cytochrome c from mitochondria cytosol; extracellular exosome gamma-glutamylcyclotransferase activity protein homodimerization activity Homo sapiens 3D-structure Alternative splicing Lyase Phosphoprotein Reference proteome MANSGCKDVT MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKTSQTWHGGIATIFQSP... |
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules | basolateral plasma membrane; extracellular exosome | calcium ion binding | Homo sapiens | Alternative splicing Calcium Cell adhesion Cell membrane Glycoprotein Membrane Metal-binding Phosphoprotein Reference proteome Repeat Signal Transmembrane Transmembrane helix | MVPAWLWLLC | MVPAWLWLLCVSVPQALPKAQPAELSVEVPENYGGNFPLYLTKLPLPREGAEGQIVLSGDSGKATEGPFAMDPDSGFLLVTRALDREEQAEYQLQVTLEMQDGHVLWGPQPVLVHVKDENDQVPHFSQAIYRARLSRGTRPGIPFLFLEASDRDEPGTANSDLRFHILSQAPAQPSPDMFQLEPRLGALALSPKGSTSLDHALERTYQLLVQVKDMGDQASGHQATATVEVSIIESTWVSLEPIHLAENLKVLYPHHMAQVHWSGGDVHYHLESHPPGPFEVNAEGNLYVTRELDREAQAEYLLQVRAQNSHGEDYAAPL... | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules basolateral plasma membrane; extracellular exosome calcium ion binding Homo sapiens Alternative splicing Calcium Cell adhesion Cell membrane Glycoprotein Membran... |
chloride transmembrane transport protein homooligomerization response to amino acid | dendrite; glycine-gated chloride channel complex; intracellular membrane-bounded organelle; neuron projection; perikaryon; plasma membrane; postsynaptic membrane; synapse | extracellularly glycine-gated chloride channel activity glycine binding glycine-gated chloride ion channel activity metal ion binding transmembrane signaling receptor activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | Homo sapiens | 3D-structure Alternative splicing Cell membrane Cell projection Chloride Chloride channel Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Membrane Metal-binding Phosphoprotein Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport... | MAHVRHFRTL | MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWM... | chloride transmembrane transport protein homooligomerization response to amino acid dendrite; glycine-gated chloride channel complex; intracellular membrane-bounded organelle; neuron projection; perikaryon; plasma membrane; postsynaptic membrane; synapse extracellularly glycine-gated chloride channel activity glycine b... |
apoptotic process involved in development axon development Cajal body organization cell population proliferation cellular response to epidermal growth factor stimulus DNA endoreduplication DNA replication inner cell mass cell proliferation microtubule cytoskeleton organization mRNA processing negative regulation of mot... | axon; Cajal body; cytoplasm; Gemini of coiled bodies; growth cone; neuronal cell body; nucleolus; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm | protein folding chaperone receptor tyrosine kinase binding translation initiation factor binding zinc ion binding | Homo sapiens | Cell projection Cytoplasm Deafness Differentiation Dwarfism Hypotrichosis Metal-binding mRNA processing mRNA splicing Nucleus Reference proteome Repeat Zinc Zinc-finger | MAASGAVEPG | MAASGAVEPGPPGAAVAPSPAPAPPPAPDHLFRPISAEDEEQQPTEIESLCMNCYCNGMTRLLLTKIPFFREIIVSSFSCEHCGWNNTEIQSAGRIQDQGVRYTLSVRALEDMNREVVKTDSAATRIPELDFEIPAFSQKGALTTVEGLITRAISGLEQDQPARRANKDATAERIDEFIVKLKELKQVASPFTLIIDDPSGNSFVENPHAPQKDDALVITHYNRTRQQEEMLGLQEEAPAEKPEEEDLRNEVLQFSTNCPECNAPAQTNMKLVQIPHFKEVIIMATNCENCGHRTNEVKSGGAVEPLGTRITLHITDASD... | apoptotic process involved in development axon development Cajal body organization cell population proliferation cellular response to epidermal growth factor stimulus DNA endoreduplication DNA replication inner cell mass cell proliferation microtubule cytoskeleton organization mRNA processing negative regulation of mot... |
protein deubiquitination proteolysis | cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane | cysteine-type deubiquitinase activity cysteine-type endopeptidase activity metal ion binding | Homo sapiens | 3D-structure Cell membrane Cytoplasm Hydrolase Membrane Metal-binding Nucleus Protease Reference proteome Thiol protease Ubl conjugation pathway Zinc | MEILMTVSKF | MEILMTVSKFASICTMGANASALEKEIGPEQFPVNEHYFGLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNTSITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYMDQLHRYTKLSYRVVFPLELRLFNTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIA... | protein deubiquitination proteolysis cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane cysteine-type deubiquitinase activity cysteine-type endopeptidase activity metal ion binding Homo sapiens 3D-structure Cell membrane Cytoplasm Hydrolase Membrane Metal-binding Nucleus Protease Reference proteome Thiol proteas... |
protein dephosphorylation RNA processing | fibrillar center; intercellular bridge; nuclear speck; nucleoplasm; nucleus | phosphatase activity polynucleotide 5'-phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity RNA binding | Homo sapiens | 3D-structure Alternative initiation Alternative splicing Hydrolase Nucleus Protein phosphatase Reference proteome RNA-binding | MSQWHHPRSG | MSQWHHPRSGWGRRRDFSGRSSAKKKGGNHIPERWKDYLPVGQRMPGTRFIAFKVPLQKSFEKKLAPEECFSPLDLFNKIREQNEELGLIIDLTYTQRYYKPEDLPETVPYLKIFTVGHQVPDDETIFKFKHAVNGFLKENKDNDKLIGVHCTHGLNRTGYLICRYLIDVEGVRPDDAIELFNRCRGHCLERQNYIEDLQNGPIRKNWNSSVPRSSDFEDSAHLMQPVHNKPVKQGPRYNLHQIQGHSAPRHFHTQTQSLQQSVRKFSENPHVYQRHHLPPPGPPGEDYSHRRYSWNVKPNASRAAQDRRRWYPYNYSRL... | protein dephosphorylation RNA processing fibrillar center; intercellular bridge; nuclear speck; nucleoplasm; nucleus phosphatase activity polynucleotide 5'-phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity RNA binding Homo sapiens 3D-structure Alternative ... |
response to toxic substance | cytoplasm; membrane; mitochondrial outer membrane | metal ion binding | Homo sapiens | 3D-structure Membrane Mitochondrion Mitochondrion outer membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix | MSIMDHSPTT | MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSAKGPCVERKAKLMTPNGPEVHG | response to toxic substance cytoplasm; membrane; mitochondrial outer membrane metal ion binding Homo sapiens 3D-structure Membrane Mitochondrion Mitochondrion outer membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix MSIMDHSPTT MSIMDHSPTTGVVTVIVILIAIAALGALILGCWCYLRLQRISQSEDEESIVGDGETKEPFLLVQYSA... |
axon extension axon guidance immune response inflammatory response integrin-mediated signaling pathway negative chemotaxis negative regulation of axon extension involved in axon guidance neural crest cell migration olfactory lobe development osteoblast differentiation positive regulation of axon extension positive regu... | external side of plasma membrane; membrane; plasma membrane | chemorepellent activity integrin binding semaphorin receptor binding | Homo sapiens | 3D-structure Alternative splicing Cell membrane Developmental protein Differentiation Disease variant Disulfide bond Glycoprotein GPI-anchor Immunoglobulin domain Inflammatory response Intrahepatic cholestasis Lipoprotein Membrane Methylation Neurogenesis Reference proteome Signal | MTPPPPGRAA | MTPPPPGRAAPSAPRARVPGPPARLGLPLRLRLLLLLWAAAASAQGHLRSGPRIFAVWKGHVGQDRVDFGQTEPHTVLFHEPGSSSVWVGGRGKVYLFDFPEGKNASVRTVNIGSTKGSCLDKRDCENYITLLERRSEGLLACGTNARHPSCWNLVNGTVVPLGEMRGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNKNFNRLQDVFLLPDPSGQWRDTR... | axon extension axon guidance immune response inflammatory response integrin-mediated signaling pathway negative chemotaxis negative regulation of axon extension involved in axon guidance neural crest cell migration olfactory lobe development osteoblast differentiation positive regulation of axon extension positive regu... |
hyaluronan catabolic process receptor-mediated endocytosis | cell surface; centrosome; cytosol; membrane; microtubule cytoskeleton; plasma membrane; spindle | cargo receptor activity hyaluronic acid binding | Homo sapiens | Alternative splicing Cytoplasm Cytoskeleton Glycoprotein Hyaluronic acid Phosphoprotein Reference proteome Repeat | MSFPKAPLKR | MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQN... | hyaluronan catabolic process receptor-mediated endocytosis cell surface; centrosome; cytosol; membrane; microtubule cytoskeleton; plasma membrane; spindle cargo receptor activity hyaluronic acid binding Homo sapiens Alternative splicing Cytoplasm Cytoskeleton Glycoprotein Hyaluronic acid Phosphoprotein Reference proteo... |
angiogenesis apoptotic signaling pathway cellular response to heat COPII vesicle coating endoplasmic reticulum to Golgi vesicle-mediated transport intracellular protein transport negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of TOR signaling negative regul... | COPII vesicle coat; Cul3-RING ubiquitin ligase complex; cytoplasm; cytoplasmic vesicle; cytosol; endoplasmic reticulum; endoplasmic reticulum exit site; endoplasmic reticulum membrane; endosome; extracellular exosome; nucleoplasm; nucleus | calcium ion binding calcium-dependent protein binding identical protein binding magnesium ion binding protein dimerization activity protein homodimerization activity protein-macromolecule adaptor activity protein-membrane adaptor activity ubiquitin ligase-substrate adaptor activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Angiogenesis Apoptosis Calcium Cytoplasm Cytoplasmic vesicle Endoplasmic reticulum Endosome Magnesium Membrane Metal-binding Nucleus Reference proteome Repeat | MAAYSYRPGP | MAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGTWTPFNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALSGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVSYEQYLSMVFSIV | angiogenesis apoptotic signaling pathway cellular response to heat COPII vesicle coating endoplasmic reticulum to Golgi vesicle-mediated transport intracellular protein transport negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of TOR signaling negative regul... |
arachidonic acid metabolic process ceramide biosynthetic process establishment of skin barrier hepoxilin biosynthetic process linoleic acid metabolic process lipid oxidation lipoxygenase pathway positive regulation of gene expression positive regulation of MAPK cascade positive regulation of mucus secretion protein lip... | cytosol; intracellular membrane-bounded organelle; perinuclear region of cytoplasm | arachidonate 12(R)-lipoxygenase activity arachidonate 12(S)-lipoxygenase activity arachidonate 8(R)-lipoxygenase activity iron ion binding isomerase activity linoleate 9S-lipoxygenase activity lyase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two at... | Homo sapiens | Cytoplasm Dioxygenase Disease variant Fatty acid metabolism Ichthyosis Iron Isomerase Lipid metabolism Lyase Metal-binding Oxidoreductase Reference proteome | MATYKVRVAT | MATYKVRVATGTDLLSGTRDSISLTIVGTQGESHKQLLNHFGRDFATGAVGQYTVQCPQDLGELIIIRLHKERYAFFPKDPWYCNYVQICAPNGRIYHFPAYQWMDGYETLALREATGKTTADDSLPVLLEHRKEEIRAKQDFYHWRVFLPGLPSYVHIPSYRPPVRRHRNPNRPEWNGYIPGFPILINFKATKFLNLNLRYSFLKTASFFVRLGPMALAFKVRGLLDCKHSWKRLKDIRKIFPGKKSVVSEYVAEHWAEDTFFGYQYLNGVNPGLIRRCTRIPDKFPVTDDMVAPFLGEGTCLQAELEKGNIYLADYRI... | arachidonic acid metabolic process ceramide biosynthetic process establishment of skin barrier hepoxilin biosynthetic process linoleic acid metabolic process lipid oxidation lipoxygenase pathway positive regulation of gene expression positive regulation of MAPK cascade positive regulation of mucus secretion protein lip... |
cGMP-mediated signaling response to oxygen levels | cytosol; guanylate cyclase complex, soluble | GTP binding guanylate cyclase activity heme binding metal ion binding | Homo sapiens | cGMP biosynthesis Cytoplasm GTP-binding Heme Iron Lyase Metal-binding Nucleotide-binding Reference proteome | MSGYDRMLRT | MSGYDRMLRTLGGNLMEFIENLDALHSYLALSYQEMNAPSFRVERGADGKMFLHYYSDRSGLCHIVPGIIEAVAKDFFDIDVIMDILDMNEEVERTGKKEHVVFLIVQKAHRKMRKTKPKRLQDSQGMERDQEALQAAFLKMKEKYLNVSACPVKKSHWDVVRSIVMFGKGHLMNTFEPIYPERLWIEEKTFCNAFPFHIVFDESLQVKQARVNIQKYVPGLQTQNIQLDEYFSIIHPQVTFNIFSIRRFINSQFVLKTRREMMPVAWQSRTTLKLQGQMIWMESMWCMVYLCSPKLRSLQELEELNMHLSDIAPNDTTR... | cGMP-mediated signaling response to oxygen levels cytosol; guanylate cyclase complex, soluble GTP binding guanylate cyclase activity heme binding metal ion binding Homo sapiens cGMP biosynthesis Cytoplasm GTP-binding Heme Iron Lyase Metal-binding Nucleotide-binding Reference proteome MSGYDRMLRT MSGYDRMLRTLGGNLMEFIENLDA... |
cell differentiation meiotic cell cycle piRNA processing positive regulation of viral genome replication protein folding regulatory ncRNA-mediated gene silencing siRNA-mediated retrotransposon silencing by heterochromatin formation spermatogenesis | cytoplasm; cytosol; synaptonemal complex | FK506 binding Hsp90 protein binding identical protein binding | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Differentiation Disease variant Meiosis Nucleus Reference proteome Repeat RNA-mediated gene silencing Spermatogenesis TPR repeat Williams-Beuren syndrome | MGGSALNQGV | MGGSALNQGVLEGDDAPGQSLYERLSQRMLDISGDRGVLKDVIREGAGDLVAPDASVLVKYSGYLEHMDRPFDSNYFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPNYAYGTLGCPPLIPPNTTVLFEIELLDFLDCAESDKFCALSAEQQDQFPLQKVLKVAATEREFGNYLFRQNRFYDAKVRYKRALLLLRRRSAPPEEQHLVEAAKLPVLLNLSFTYLKLDRPTIALCYGEQALIIDQKNAKALFRCGQACLLLTEYQKARDFLVRAQKEQPFNHDINNELKKLASCYRDYVDKEKEMWHRMFAPCGD... | cell differentiation meiotic cell cycle piRNA processing positive regulation of viral genome replication protein folding regulatory ncRNA-mediated gene silencing siRNA-mediated retrotransposon silencing by heterochromatin formation spermatogenesis cytoplasm; cytosol; synaptonemal complex FK506 binding Hsp90 protein bin... |
post-chaperonin tubulin folding pathway protein folding tubulin complex assembly | cytoplasm; microtubule; microtubule cytoskeleton; nucleolus | beta-tubulin binding protein-folding chaperone binding RNA binding tubulin binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Chaperone Cytoplasm Cytoskeleton Microtubule Reference proteome | MADPRVRQIK | MADPRVRQIKIKTGVVKRLVKEKVMYEKEAKQQEEKIEKMRAEDGENYDIKKQAEILQESRMMIPDCQRRLEAAYLDLQRILENEKDLEEAEEYKEARLVLDSVKLEA | post-chaperonin tubulin folding pathway protein folding tubulin complex assembly cytoplasm; microtubule; microtubule cytoskeleton; nucleolus beta-tubulin binding protein-folding chaperone binding RNA binding tubulin binding Homo sapiens 3D-structure Acetylation Alternative splicing Chaperone Cytoplasm Cytoskeleton Micr... |
cellular response to increased oxygen levels intracellular iron ion homeostasis regulation of macroautophagy synaptic vesicle lumen acidification | apical plasma membrane; cytosol; extracellular exosome; lysosomal membrane; plasma membrane; presynapse; transmembrane transporter complex; vacuolar proton-transporting V-type ATPase complex; vacuolar proton-transporting V-type ATPase, V1 domain | ATP hydrolysis activity ATPase binding proton-transporting ATPase activity, rotational mechanism | Homo sapiens | 3D-structure Acetylation Cell membrane Direct protein sequencing Hydrogen ion transport Ion transport Membrane Reference proteome Transport | MASQSQGIQQ | MASQSQGIQQLLQAEKRAAEKVSEARKRKNRRLKQAKEEAQAEIEQYRLQREKEFKAKEAAALGSRGSCSTEVEKETQEKMTILQTYFRQNRDEVLDNLLAFVCDIRPEIHENYRING | cellular response to increased oxygen levels intracellular iron ion homeostasis regulation of macroautophagy synaptic vesicle lumen acidification apical plasma membrane; cytosol; extracellular exosome; lysosomal membrane; plasma membrane; presynapse; transmembrane transporter complex; vacuolar proton-transporting V-typ... |
nucleoside diphosphate catabolic process response to calcium ion response to magnesium ion | cell surface; extracellular region; extracellular space; Golgi apparatus; Golgi membrane; membrane; plasma membrane | CDP phosphatase activity GDP phosphatase activity guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity IDP phosphatase activity nucleoside diphosphate phosphatase activity ribonucleoside triphosphate phosphatase activity UDP phosphatase activity | Homo sapiens | Alternative splicing Calcium Cell membrane Disulfide bond Glycoprotein Golgi apparatus Hydrolase Magnesium Membrane Reference proteome Secreted Signal-anchor Transmembrane Transmembrane helix | MKKGIRYETS | MKKGIRYETSRKTSYIFQQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKE... | nucleoside diphosphate catabolic process response to calcium ion response to magnesium ion cell surface; extracellular region; extracellular space; Golgi apparatus; Golgi membrane; membrane; plasma membrane CDP phosphatase activity GDP phosphatase activity guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity... |
nucleoside diphosphate catabolic process nucleoside triphosphate catabolic process | plasma membrane | apyrase activity ATP binding GDP phosphatase activity nucleoside diphosphate phosphatase activity ribonucleoside triphosphate phosphatase activity UDP phosphatase activity | Homo sapiens | Alternative splicing ATP-binding Calcium Cell membrane Disulfide bond Glycoprotein Hydrolase Magnesium Membrane Nucleotide-binding Reference proteome Transmembrane Transmembrane helix | MFTVLTRQPC | MFTVLTRQPCEQAGLKALYRTPTIIALVVLLVSIVVLVSITVIQIHKQEVLPPGLKYGIVLDAGSSRTTVYVYQWPAEKENNTGVVSQTFKCSVKGSGISSYGNNPQDVPRAFEECMQKVKGQVPSHLHGSTPIHLGATAGMRLLRLQNETAANEVLESIQSYFKSQPFDFRGAQIISGQEEGVYGWITANYLMGNFLEKNLWHMWVHPHGVETTGALDLGGASTQISFVAGEKMDLNTSDIMQVSLYGYVYTLYTHSFQCYGRNEAEKKFLAMLLQNSPTKNHLTNPCYPRDYSISFTMGHVFDSLCTVDQRPESYNPN... | nucleoside diphosphate catabolic process nucleoside triphosphate catabolic process plasma membrane apyrase activity ATP binding GDP phosphatase activity nucleoside diphosphate phosphatase activity ribonucleoside triphosphate phosphatase activity UDP phosphatase activity Homo sapiens Alternative splicing ATP-binding Cal... |
de novo' post-translational protein folding nucleoside diphosphate catabolic process protein N-linked glycosylation UDP catabolic process UDP-glucose metabolic process | endoplasmic reticulum; extracellular region; extracellular space; membrane | ADP phosphatase activity CDP phosphatase activity GDP phosphatase activity IDP phosphatase activity UDP phosphatase activity | Homo sapiens | Calcium Disulfide bond Endoplasmic reticulum Glycoprotein Hydrolase Magnesium Proto-oncogene Reference proteome Secreted Signal | MATSWGTVFF | MATSWGTVFFMLVVSCVCSAVSHRNQQTWFEGIFLSSMCPINVSASTLYGIMFDAGSTGTRIHVYTFVQKMPGQLPILEGEVFDSVKPGLSAFVDQPKQGAETVQGLLEVAKDSIPRSHWKKTPVVLKATAGLRLLPEHKAKALLFEVKEIFRKSPFLVPKGSVSIMDGSDEGILAWVTVNFLTGQLHGHRQETVGTLDLGGASTQITFLPQFEKTLEQTPRGYLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRSACLPRWLEAEWIFGGVKYQYGGNQEGEVGFEPCYAEVLRVVRGKLHQPEE... | de novo' post-translational protein folding nucleoside diphosphate catabolic process protein N-linked glycosylation UDP catabolic process UDP-glucose metabolic process endoplasmic reticulum; extracellular region; extracellular space; membrane ADP phosphatase activity CDP phosphatase activity GDP phosphatase activity ID... |
apoptotic process blood vessel development cell migration central nervous system development dorsal/ventral pattern formation hypophysis morphogenesis hypothalamus cell differentiation negative regulation of apoptotic process regulation of transcription by RNA polymerase II somatotropin secreting cell differentiation | chromatin; nucleus; transcription regulator complex | beta-catenin binding chromatin binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA bin... | Homo sapiens | Disease variant DNA-binding Dwarfism Homeobox Nucleus Reference proteome | MEAERRRQAE | MEAERRRQAEKPKKGRVGSNLLPERHPATGTPTTTVDSSAPPCRRLPGAGGGRSRFSPQGGQRGRPHSRRRHRTTFSPVQLEQLESAFGRNQYPDIWARESLARDTGLSEARIQVWFQNRRAKQRKQERSLLQPLAHLSPAAFSSFLPESTACPYSYAAPPPPVTCFPHPYSHALPSQPSTGGAFALSHQSEDWYPTLHPAPAGHLPCPPPPPMLPLSLEPSKSWN | apoptotic process blood vessel development cell migration central nervous system development dorsal/ventral pattern formation hypophysis morphogenesis hypothalamus cell differentiation negative regulation of apoptotic process regulation of transcription by RNA polymerase II somatotropin secreting cell differentiation c... |
anatomical structure morphogenesis animal organ morphogenesis cellular response to glial cell derived neurotrophic factor dopaminergic neuron differentiation lens development in camera-type eye lens fiber cell differentiation lens morphogenesis in camera-type eye locomotory behavior midbrain development negative regula... | chromatin; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Activator Cataract Developmental protein Disease variant DNA-binding Homeobox Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MEFGLLSEAE | MEFGLLSEAEARSPALSLSDAGTPHPQLPEHGCKGQEHSDSEKASASLPGGSPEDGSLKKKQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERSQQAELCKGSFAAPLGGLVPPYEEVYPGYSYGNWPPKALAPPLAAKTFPFAFNSVNVGPLASQPVFSPPSSIAASMVPSAAAAPGTVPGPGALQGLGGGPPGLAPAAVSSGAVSCPYASAAAAAAAAASSPYVYRDPCNSSLASLRLKAKQHASFSYPAVHGPPPAANLSPCQYAVERPV | anatomical structure morphogenesis animal organ morphogenesis cellular response to glial cell derived neurotrophic factor dopaminergic neuron differentiation lens development in camera-type eye lens fiber cell differentiation lens morphogenesis in camera-type eye locomotory behavior midbrain development negative regula... |
cellular response to leukemia inhibitory factor dephosphorylation endothelial cell migration Notch signaling pathway positive regulation of establishment of protein localization positive regulation of non-canonical NF-kappaB signal transduction positive regulation of vascular permeability regulation of DNA-templated tr... | cytoplasm; early endosome; nucleus; plasma membrane | prenylated protein tyrosine phosphatase activity protein tyrosine phosphatase activity | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disulfide bond Endosome Hydrolase Lipoprotein Membrane Methylation Prenylation Protein phosphatase Reference proteome | MARMNRPAPV | MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM | cellular response to leukemia inhibitory factor dephosphorylation endothelial cell migration Notch signaling pathway positive regulation of establishment of protein localization positive regulation of non-canonical NF-kappaB signal transduction positive regulation of vascular permeability regulation of DNA-templated tr... |
actin filament organization actin filament severing actin polymerization or depolymerization barbed-end actin filament capping cilium assembly nervous system development positive regulation of lamellipodium assembly positive regulation of neuron projection development regulation of diacylglycerol biosynthetic process | actin cytoskeleton; actin filament; axon; cell projection; cytoplasm; focal adhesion; lamellipodium; neuron projection | actin binding actin filament binding Arp2/3 complex binding phosphatidylinositol-4,5-bisphosphate binding | Homo sapiens | 3D-structure Actin capping Actin-binding Alternative splicing Calcium Cell junction Cell projection Cytoplasm Cytoskeleton Disease variant Phosphoprotein Reference proteome Repeat | MPLTSAFRAV | MPLTSAFRAVDNDPGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAKIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDEIIDQKQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSKALGFIKMKS... | actin filament organization actin filament severing actin polymerization or depolymerization barbed-end actin filament capping cilium assembly nervous system development positive regulation of lamellipodium assembly positive regulation of neuron projection development regulation of diacylglycerol biosynthetic process a... |
positive regulation of cytoplasmic translational initiation proteasome-mediated ubiquitin-dependent protein catabolic process | cytoplasm; cytosol; extracellular exosome; extracellular space; nucleus; plasma membrane | protein-RNA adaptor activity SH3 domain binding ubiquitin ligase-substrate adaptor activity | Homo sapiens | 3D-structure Cell membrane Cytoplasm Membrane Reference proteome SH3-binding | MVIRVYIASS | MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA | positive regulation of cytoplasmic translational initiation proteasome-mediated ubiquitin-dependent protein catabolic process cytoplasm; cytosol; extracellular exosome; extracellular space; nucleus; plasma membrane protein-RNA adaptor activity SH3 domain binding ubiquitin ligase-substrate adaptor activity Homo sapiens ... |
cellular response to reactive oxygen species microtubule anchoring negative regulation of DNA-binding transcription factor activity negative regulation of DNA-templated transcription negative regulation of protein binding peroxisome organization peroxisome transport along microtubule protein import into peroxisome matr... | cytosol; fibrillar center; membrane; nucleus; peroxisomal importomer complex; peroxisomal membrane; peroxisome; protein-containing complex | beta-tubulin binding identical protein binding microtubule binding protein transmembrane transporter activity protein-macromolecule adaptor activity signaling receptor binding transcription corepressor activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Direct protein sequencing Membrane Peroxisome Peroxisome biogenesis disorder Phosphoprotein Protein transport Reference proteome Translocation Transmembrane Transmembrane helix Transport Zellweger syndrome | MASSEQAEQP | MASSEQAEQPSQPSSTPGSENVLPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDMAFQQSGTAADEPSSLGPATQVVPVQPPHLISQPYSPAGSRWRDYGALAIIMAGIAFGFHQLYKKYLLPLILGGREDRKQLERMEAGLSELSGSVAQTVTQLQTTLASVQELLIQQQQKIQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESTSSSPGKEGHSPEGSTVTYHLLGPQEEGEGVVDVKGQVRMEVQGEEEKR... | cellular response to reactive oxygen species microtubule anchoring negative regulation of DNA-binding transcription factor activity negative regulation of DNA-templated transcription negative regulation of protein binding peroxisome organization peroxisome transport along microtubule protein import into peroxisome matr... |
negative regulation of translation nervous system development positive regulation of toll-like receptor 3 signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process protein K63-linked ubiquitination protein polyubiquitination protein transport | cytoplasm; dendrite; early endosome; Golgi apparatus | identical protein binding translation repressor activity ubiquitin protein ligase activity zinc ion binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cell projection Coiled coil Cytoplasm Endosome Golgi apparatus Metal-binding Phosphoprotein Protein transport Reference proteome Repeat Transferase Transport Zinc Zinc-finger | MAKREDSPGP | MAKREDSPGPEVQPMDKQFLVCSICLDRYQCPKVLPCLHTFCERCLQNYIPAQSLTLSCPVCRQTSILPEQGVSALQNNFFISSLMEAMQQAPDGAHDPEDPHPLSVVAGRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREHGTVLLRDVVEQHKAALQRQLEAVRGRLPQLSAAIALVGGISQQLQERKAEALAQISAAFEDLEQALQQRKQALVSDLETICGAKQKVLQSQLDTLRQGQEHIGSSCSFAEQALRLGSAPEVLLVRKHMRERLAALAAQAFPERPHENAQLELVLEVDGLRRSVLNLGALLTTSA... | negative regulation of translation nervous system development positive regulation of toll-like receptor 3 signaling pathway proteasome-mediated ubiquitin-dependent protein catabolic process protein K63-linked ubiquitination protein polyubiquitination protein transport cytoplasm; dendrite; early endosome; Golgi apparatu... |
anterior/posterior pattern specification bone development brain development bronchus morphogenesis central nervous system neuron differentiation embryonic camera-type eye development embryonic digit morphogenesis embryonic neurocranium morphogenesis G protein-coupled receptor signaling pathway ganglion development nega... | 9+0 non-motile cilium; axoneme; ciliary base; cilium; extracellular region; nucleolus; nucleoplasm; nucleus; plasma membrane | enzyme binding G protein-coupled receptor binding intraciliary transport particle A binding phosphatidylinositol binding phosphatidylinositol-4,5-bisphosphate binding protein-containing complex binding | Homo sapiens | 3D-structure Alternative splicing Cell membrane Cell projection Ciliopathy Cilium Cytoplasm Developmental protein Disease variant Membrane Nucleus Reference proteome Secreted | MEASRCRLSP | MEASRCRLSPSGDSVFHEEMMKMRQAKLDYQRLLLEKRQRKKRLEPFMVQPNPEARLRRAKPRASDEQTPLVNCHTPHSNVILHGIDGPAAVLKPDEVHAPSVSSSVVEEDAENTVDTASKPGLQERLQKHDISESVNFDEETDGISQSACLERPNSASSQNSTDTGTSGSATAAQPADNLLGDIDDLEDFVYSPAPQGVTVRCRIIRDKRGMDRGLFPTYYMYLEKEENQKIFLLAARKRKKSKTANYLISIDPVDLSREGESYVGKLRSNLMGTKFTVYDRGICPMKGRGLVGAAHTRQELAAISYETNVLGFKGPRK... | anterior/posterior pattern specification bone development brain development bronchus morphogenesis central nervous system neuron differentiation embryonic camera-type eye development embryonic digit morphogenesis embryonic neurocranium morphogenesis G protein-coupled receptor signaling pathway ganglion development nega... |
amino acid transport isoleucine transport L-valine transmembrane transport leucine transport negative regulation of amino acid transport negative regulation of leucine import neutral amino acid transport | apical plasma membrane; endoplasmic reticulum membrane; plasma membrane; podocyte foot | amino acid transmembrane transporter activity L-amino acid transmembrane transporter activity L-isoleucine transmembrane transporter activity L-leucine transmembrane transporter activity L-valine transmembrane transporter activity neutral L-amino acid transmembrane transporter activity | Homo sapiens | Alternative splicing Amino-acid transport Cell membrane Endoplasmic reticulum Glycoprotein Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport | MAPTLQQAYR | MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTCPAESSTNTTQDEQRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLPNMFGNLRSTLMALMIGSYASSAITFPGIKLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYTKKIKLSGLALDHKVTGDLFYTHVTTMGQRLSQKAPSLEDGSDAFMSPQDVRGTSENLPERSVPLRKSLCSPTFLWSLLTMGMTQLRIIF... | amino acid transport isoleucine transport L-valine transmembrane transport leucine transport negative regulation of amino acid transport negative regulation of leucine import neutral amino acid transport apical plasma membrane; endoplasmic reticulum membrane; plasma membrane; podocyte foot amino acid transmembrane tran... |
carbohydrate metabolic process citrate metabolic process tricarboxylic acid cycle | extracellular exosome; mitochondrial matrix; mitochondrion; nucleus | citrate (Si)-synthase activity RNA binding | Homo sapiens | 3D-structure Acetylation Direct protein sequencing Methylation Mitochondrion Reference proteome Transferase Transit peptide Tricarboxylic acid cycle | MALLTAAARL | MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVVGQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLFWLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFARAYAQGISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSHNFTNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVG... | carbohydrate metabolic process citrate metabolic process tricarboxylic acid cycle extracellular exosome; mitochondrial matrix; mitochondrion; nucleus citrate (Si)-synthase activity RNA binding Homo sapiens 3D-structure Acetylation Direct protein sequencing Methylation Mitochondrion Reference proteome Transferase Transi... |
endoplasmic reticulum to Golgi vesicle-mediated transport negative regulation of autophagosome assembly positive regulation of protein catabolic process protein transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum vesicle fusion with Golgi apparatus | endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; ER to Golgi transport vesicle membrane; Golgi membrane; melanosome; phagocytic vesicle membrane; SNARE complex; transport vesicle | SNAP receptor activity | Homo sapiens | 3D-structure Acetylation Coiled coil Direct protein sequencing Endoplasmic reticulum ER-Golgi transport Golgi apparatus Membrane Phosphoprotein Protein transport Reference proteome Transmembrane Transmembrane helix Transport | MVLLTMIARV | MVLLTMIARVADGLPLAASMQEDEQSGRDLQQYQSQAKQLFRKLNEQSPTRCTLEAGAMTFHYIIEQGVCYLVLCEAAFPKKLAFAYLEDLHSEFDEQHGKKVPTVSRPYSFIEFDTFIQKTKKLYIDSRARRNLGSINTELQDVQRIMVANIEEVLQRGEALSALDSKANNLSSLSKKYRQDAKYLNMRSTYAKLAAVAVFFIMLIVYVRFWWL | endoplasmic reticulum to Golgi vesicle-mediated transport negative regulation of autophagosome assembly positive regulation of protein catabolic process protein transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum vesicle fusion with Golgi apparatus endoplasmic reticulum membrane; endoplasmic... |
anatomical structure morphogenesis embryonic skeletal system development germ cell development negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II neural tube closure positive regulation of DNA-templated transcription regulation of mammary gland epithelial cell p... | chromatin; cytoplasm; extracellular region; fibrillar center; nucleoplasm; nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific metal ion binding RNA polymerase II transcription regulatory region sequence-specific DNA binding | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Developmental protein Disease variant DNA-binding Epilepsy Intellectual disability Metal-binding Neurogenesis Nucleus Phosphoprotein Reference proteome Secreted Transcription Transcription regulation Zinc Zinc-finger | MEDSDSAAKQ | MEDSDSAAKQLGLAEAAAVAAAAAVAAAAAAAAGGEAEEPVLSRDEDSEEDADSEAERETPRVTAVAVMAAEPGHMDMGAEALPGPDEAAAAAAFAEVTTVTVANVGAAADNVFTTSVANAASISGHVLSGRTALQIGDSLNTEKATLIVVHTDGSIVETTGLKGPAAPLTPGPQSPPTPLAPGQEKGGTKYNWDPSVYDSELPVRCRNISGTLYKNRLGSGGRGRCIKQGENWYSPTEFEAMAGRASSKDWKRSIRYAGRPLQCLIQDGILNPHAASCTCAACCDDMTLSGPVRLFVPYKRRKKENELPTTPVKKDSPK... | anatomical structure morphogenesis embryonic skeletal system development germ cell development negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II neural tube closure positive regulation of DNA-templated transcription regulation of mammary gland epithelial cell p... |
cell cycle cell division cell migration cytoskeleton organization mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome regulation of cell shape regulation of cytokinesis | membrane; nuclear matrix; nuclear speck; nucleoplasm; U1 snRNP; U2-type prespliceosome | RNA binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cell cycle Cell division Isopeptide bond Methylation mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Repeat Ubl conjugation | MRPGTGAERG | MRPGTGAERGGLMVSEMESHPPSQGPGDGERRLSGSSLCSGSWVSADGFLRRRPSMGHPGMHYAPMGMHPMGQRANMPPVPHGMMPQMMPPMGGPPMGQMPGMMSSVMPGMMMSHMSQASMQPALPPGVNSMDVAAGTASGAKSMWTEHKSPDGRTYYYNTETKQSTWEKPDDLKTPAEQLLSKCPWKEYKSDSGKPYYYNSQTKESRWAKPKELEDLEGYQNTIVAGSLITKSNLHAMIKAEESSKQEECTTTSTAPVPTTEIPTTMSTMAAAEAAAAVVAAAAAAAAAAAAANANASTSASNTVSGTVPVVPEPEVTS... | cell cycle cell division cell migration cytoskeleton organization mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome regulation of cell shape regulation of cytokinesis membrane; nuclear matrix; nuclear speck; nucleoplasm; U1 snRNP; U2-type prespliceosome RNA binding Homo sapiens 3D-structure Acetylation ... |
cell division cell population proliferation cerebral cortex development microtubule cytoskeleton organization mitotic spindle organization | centrosome; cytoplasm; cytosol; membrane; midbody; nucleus | nuclear estrogen receptor binding nuclear glucocorticoid receptor binding nuclear receptor binding nuclear receptor coactivator activity nuclear retinoic acid receptor binding nuclear retinoid X receptor binding nuclear thyroid hormone receptor binding peroxisome proliferator activated receptor binding | Homo sapiens | Acetylation Activator Alternative splicing Cell cycle Cell division Coiled coil Cytoplasm Cytoskeleton Lipoprotein Membrane Myristate Nucleus Phosphoprotein Reference proteome Repeat | MAFSPWQILS | MAFSPWQILSPVQWAKWTWSAVRGGAAGEDEAGGPEGDPEEEDSQAETKSLSFSSDSEGNFETPEAETPIRSPFKESCDPSLGLAGPGAKSQESQEADEQLVAEVVEKCSSKTCSKPSENEVPQQAIDSHSVKNFREEPEHDFSKISIVRPFSIETKDSTDISAVLGTKAAHGCVTAVSGKALPSSPPDALQDEAMTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRSSPLKL... | cell division cell population proliferation cerebral cortex development microtubule cytoskeleton organization mitotic spindle organization centrosome; cytoplasm; cytosol; membrane; midbody; nucleus nuclear estrogen receptor binding nuclear glucocorticoid receptor binding nuclear receptor binding nuclear receptor coacti... |
apoptotic process CTP biosynthetic process GTP biosynthetic process negative regulation of cell growth negative regulation of mitotic nuclear division phosphorylation UTP biosynthetic process | mitochondrial inner membrane; mitochondrial matrix; mitochondrion | ATP binding metal ion binding nucleoside diphosphate kinase activity | Homo sapiens | Alternative splicing Apoptosis ATP-binding Kinase Magnesium Metal-binding Nucleotide metabolism Nucleotide-binding Reference proteome Transferase | MASILRSPQA | MASILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWRKEDCQRFYREHEGRFFYQRLVEFMASGPIRAYILAHKDAIQLWRTLMGPTRVFRARHVAPDSIRGSFGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVCYSPEGGVHYVAGTGGLGPA | apoptotic process CTP biosynthetic process GTP biosynthetic process negative regulation of cell growth negative regulation of mitotic nuclear division phosphorylation UTP biosynthetic process mitochondrial inner membrane; mitochondrial matrix; mitochondrion ATP binding metal ion binding nucleoside diphosphate kinase ac... |
DNA replication checkpoint signaling DNA replication initiation DNA unwinding involved in DNA replication double-strand break repair via break-induced replication mitotic DNA replication preinitiation complex assembly | centrosome; ciliary basal body; CMG complex; DNA replication preinitiation complex; nucleoplasm; nucleus | chromatin binding DNA replication origin binding single-stranded DNA binding | Homo sapiens | 3D-structure Alternative splicing Cell cycle Chromosome Disease variant DNA replication Dwarfism Nucleus Phosphoprotein Reference proteome | MFVSDFRKEF | MFVSDFRKEFYEVVQSQRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAFLEHKEQFHYFILINCGANVDLLDILQPDEDTIFFVCDTHRPVNVVNVYNDTQIKLLIKQDDDLEVPAYEDIFRDEEEDEEHSGNDSDGSEPSEKRTRLEEEIVEQTMRRRQRREWEARRRDILFDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRHNHRNEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLADMGL... | DNA replication checkpoint signaling DNA replication initiation DNA unwinding involved in DNA replication double-strand break repair via break-induced replication mitotic DNA replication preinitiation complex assembly centrosome; ciliary basal body; CMG complex; DNA replication preinitiation complex; nucleoplasm; nucle... |
mitochondrial calcium ion transmembrane transport protein processing involved in protein targeting to mitochondrion | mitochondrial inner membrane; mitochondrial processing peptidase complex; mitochondrion | metal ion binding metalloendopeptidase activity | Homo sapiens | Direct protein sequencing Disease variant Hydrolase Metal-binding Metalloprotease Mitochondrion Neurodegeneration Protease Reference proteome Transit peptide Zinc | MAAAAARVVL | MAAAAARVVLSSAARRRLWGFSESLLIRGAAGRSLYFGENRLRSTQAATQVVLNVPETRVTCLESGLRVASEDSGLSTCTVGLWIDAGSRYENEKNNGTAHFLEHMAFKGTKKRSQLDLELEIENMGAHLNAYTSREQTVYYAKAFSKDLPRAVEILADIIQNSTLGEAEIERERGVILREMQEVETNLQEVVFDYLHATAYQNTALGRTILGPTENIKSISRKDLVDYITTHYKGPRIVLAAAGGVSHDELLDLAKFHFGDSLCTHKGEIPALPPCKFTGSEIRVRDDKMPLAHLAIAVEAVGWAHPDTICLMVANTLI... | mitochondrial calcium ion transmembrane transport protein processing involved in protein targeting to mitochondrion mitochondrial inner membrane; mitochondrial processing peptidase complex; mitochondrion metal ion binding metalloendopeptidase activity Homo sapiens Direct protein sequencing Disease variant Hydrolase Met... |
inner ear development integrated stress response signaling lens fiber cell differentiation megakaryocyte differentiation negative regulation of transcription by RNA polymerase II positive regulation of gene expression regulation of chondrocyte differentiation regulation of transcription by RNA polymerase II transcripti... | chromatin; cytoplasm; nucleus; RNA polymerase II transcription regulator complex | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific identical protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Activator Alternative splicing Cataract Chromosomal rearrangement Deafness Disease variant DNA-binding Dwarfism Intellectual disability Isopeptide bond Nucleus Proto-oncogene Reference proteome Repressor Transcription Transcription regulation Tumor suppressor Ubl conjugation | MASELAMSNS | MASELAMSNSDLPTSPLAMEYVNDFDLMKFEVKKEPVETDRIISQCGRLIAGGSLSSTPMSTPCSSVPPSPSFSAPSPGSGSEQKAHLEDYYWMTGYPQQLNPEALGFSPEDAVEALISNSHQLQGGFDGYARGAQQLAAAAGAGAGASLGGSGEEMGPAAAVVSAVIAAAAAQSGAGPHYHHHHHHAAGHHHHPTAGAPGAAGSAAASAGGAGGAGGGGPASAGGGGGGGGGGGGGGAAGAGGALHPHHAAGGLHFDDRFSDEQLVTMSVRELNRQLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLESEK... | inner ear development integrated stress response signaling lens fiber cell differentiation megakaryocyte differentiation negative regulation of transcription by RNA polymerase II positive regulation of gene expression regulation of chondrocyte differentiation regulation of transcription by RNA polymerase II transcripti... |
modulation by host of symbiont transcription negative regulation of cell migration negative regulation of stem cell population maintenance negative regulation of transcription by RNA polymerase II negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of stem cell populati... | histone deacetylase complex; nucleoplasm; nucleus | DNA binding metal ion binding transcription coregulator activity transcription corepressor activity | Homo sapiens | 3D-structure DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MNGFTPDEMS | MNGFTPDEMSRGGDAAAAVAAVVAAAAAAASAGNGTGAGTGAEVPGAGAVSAAGPPGAAGPGPGQLCCLREDGERCGRAAGNASFSKRIQKSISQKKVKIELDKSARHLYICDYHKNLIQSVRNRRKRKGSDDDGGDSPVQDIDTPEVDLYQLQVNTLRRYKRHFKLPTRPGLNKAQLVEIVGCHFRSIPVNEKDTLTYFIYSVKNDKNKSDLKVDSGVH | modulation by host of symbiont transcription negative regulation of cell migration negative regulation of stem cell population maintenance negative regulation of transcription by RNA polymerase II negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of stem cell populati... |
positive regulation of DNA-templated transcription positive regulation of transcription elongation by RNA polymerase II positive regulation of transcription initiation by RNA polymerase II RNA polymerase II preinitiation complex assembly | core mediator complex; mediator complex; nucleoplasm; nucleus | nuclear receptor coactivator activity nuclear thyroid hormone receptor binding nuclear vitamin D receptor binding transcription coactivator activity transcription coregulator activity | Homo sapiens | 3D-structure Activator Alternative splicing Direct protein sequencing Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation | MKVVNLKQAI | MKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLADALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLREGLEAGTPAAGEKQLAMCLQRLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAEQCGTLIRSIPTMLSVHAEQMHKTGFPTVHAVILLEGTMNLTGETQSLVEQLTMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTFLKIPQVLVKL... | positive regulation of DNA-templated transcription positive regulation of transcription elongation by RNA polymerase II positive regulation of transcription initiation by RNA polymerase II RNA polymerase II preinitiation complex assembly core mediator complex; mediator complex; nucleoplasm; nucleus nuclear receptor coa... |
cell cycle cell division cytoplasmic microtubule organization microtubule severing | centrosome; cytoplasm; katanin complex; microtubule; microtubule cytoskeleton; midbody; mitotic spindle pole; spindle; spindle pole | ATP binding ATP hydrolysis activity isomerase activity microtubule binding microtubule severing ATPase activity protein heterodimerization activity | Homo sapiens | 3D-structure Alternative splicing ATP-binding Cell cycle Cell division Cytoplasm Cytoskeleton Isomerase Microtubule Mitosis Nucleotide-binding Phosphoprotein Reference proteome Ubl conjugation | MSLLMISENV | MSLLMISENVKLAREYALLGNYDSAMVYYQGVLDQMNKYLYSVKDTYLQQKWQQVWQEINVEAKHVKDIMKTLESFKLDSTPLKAAQHDLPASEGEVWSMPVPVERRPSPGPRKRQSSQYSDPKSHGNRPSTTVRVHRSSAQNVHNDRGKAVRCREKKEQNKGREEKNKSPAAVTEPETNKFDSTGYDKDLVEALERDIISQNPNVRWDDIADLVEAKKLLKEAVVLPMWMPEFFKGIRRPWKGVLMVGPPGTGKTLLAKAVATECKTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYSPATIFIDEIDSICSRRGTS... | cell cycle cell division cytoplasmic microtubule organization microtubule severing centrosome; cytoplasm; katanin complex; microtubule; microtubule cytoskeleton; midbody; mitotic spindle pole; spindle; spindle pole ATP binding ATP hydrolysis activity isomerase activity microtubule binding microtubule severing ATPase ac... |
lipid metabolic process retinol metabolic process steroid metabolic process | endoplasmic reticulum membrane; intracellular membrane-bounded organelle | 11-cis-retinol dehydrogenase androstan-3-alpha,17-beta-diol dehydrogenase activity androsterone dehydrogenase activity electron transfer activity identical protein binding NAD-retinol dehydrogenase activity | Homo sapiens | Endoplasmic reticulum Lipid metabolism Membrane Microsome NAD Oxidoreductase Reference proteome Steroid metabolism Transmembrane Transmembrane helix | MWLYLAVFVG | MWLYLAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISKYGVEAFSDSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDAIMYWVSPSPAKAL | lipid metabolic process retinol metabolic process steroid metabolic process endoplasmic reticulum membrane; intracellular membrane-bounded organelle 11-cis-retinol dehydrogenase androstan-3-alpha,17-beta-diol dehydrogenase activity androsterone dehydrogenase activity electron transfer activity identical protein binding... |
cellular response to glucose stimulus cellular response to hydrogen peroxide cellular response to unfolded protein cellular response to vascular endothelial growth factor stimulus endothelial cell proliferation insulin metabolic process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress I... | AIP1-IRE1 complex; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; Ire1 complex; IRE1-RACK1-PP2A complex; IRE1-TRAF2-ASK1 complex; mitochondrion; nuclear inner membrane | ADP binding ATP binding enzyme binding Hsp70 protein binding Hsp90 protein binding identical protein binding magnesium ion binding platelet-derived growth factor receptor binding protein homodimerization activity protein serine kinase activity protein serine/threonine kinase activity RNA endonuclease activity unfolded ... | Homo sapiens | 3D-structure ADP-ribosylation Alternative splicing Apoptosis ATP-binding Disulfide bond Endoplasmic reticulum Glycoprotein Hydrolase Kinase Magnesium Membrane Metal-binding Multifunctional enzyme Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Signal Transcription Transcription regu... | MPARRLLLLL | MPARRLLLLLTLLLPGLGIFGSTSTVTLPETLLFVSTLDGSLHAVSKRTGSIKWTLKEDPVLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEGLTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLCPSTSLLYLGRTEYTITMYDTKTRELRWNATYFDYAASLPEDDVDYKMSHFVSNGDGLVVTVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMSGEVGRITKWKYPFPKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLPLLEGPQ... | cellular response to glucose stimulus cellular response to hydrogen peroxide cellular response to unfolded protein cellular response to vascular endothelial growth factor stimulus endothelial cell proliferation insulin metabolic process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress I... |
cell cycle negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | chromatin; MLL1 complex; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex | DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific protein dimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | Alternative splicing Cell cycle DNA-binding Isopeptide bond Nucleus Reference proteome Repressor Transcription Transcription regulation Ubl conjugation | MSQQRPARKL | MSQQRPARKLPSLLLDPTEETVRRRCRDPINVEGLLPSKIRINLEDNVQYVSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIDLVEKKSKNHIRWIGSDLSNFGAVPQQKKLQEELSDLSAMEDALDELIKDCAQQLFELTDDKENERLAYVTYQDIHSIQAFHEQIVIAVKAPAETRLDVPAPREDSITVHIRSTNGPIDVYLCEVEQGQTSNKRSEGVGTSSSESTHPEGPEEEENPQQSEELLEVSN | cell cycle negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II chromatin; MLL1 complex; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor... |
cytokine-mediated signaling pathway negative regulation of motor neuron apoptotic process negative regulation of neuron apoptotic process positive regulation of cell population proliferation positive regulation of tyrosine phosphorylation of STAT protein ureteric bud development | CRLF-CLCF1 complex; cytosol; external side of plasma membrane; extracellular region; extracellular space; receptor complex | cytokine binding cytokine receptor activity | Homo sapiens | 3D-structure Direct protein sequencing Disease variant Disulfide bond Glycoprotein Immunoglobulin domain Phosphoprotein Receptor Reference proteome Repeat Secreted Signal | MPAGRRGPAA | MPAGRRGPAAQSARRPPPLLPLLLLLCVLGAPRAGSGAHTAVISPQDPTLLIGSSLLATCSVHGDPPGATAEGLYWTLNGRRLPPELSRVLNASTLALALANLNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPGAHGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQIRYRVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYG... | cytokine-mediated signaling pathway negative regulation of motor neuron apoptotic process negative regulation of neuron apoptotic process positive regulation of cell population proliferation positive regulation of tyrosine phosphorylation of STAT protein ureteric bud development CRLF-CLCF1 complex; cytosol; external si... |
cell differentiation negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription positive regulation of gene expression positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription ... | chromatin; intermediate filament cytoskeleton; nuclear body; nucleoplasm; transcription regulator complex | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific nuclear receptor activity nuclear receptor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II transcription regulatory region sequen... | Homo sapiens | 3D-structure Activator Alternative splicing DNA-binding Metal-binding Nucleus Receptor Reference proteome Transcription Transcription regulation Zinc Zinc-finger | MEVRPKESWN | MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLL... | cell differentiation negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription positive regulation of gene expression positive regulation of transcription by RNA polymerase II regulation of DNA-templated transcription ... |
adenylate cyclase-activating G protein-coupled receptor signaling pathway epithelial cell proliferation involved in renal tubule morphogenesis G protein-coupled receptor signaling pathway hair follicle development inner ear development oocyte differentiation positive regulation of canonical Wnt signaling pathway regula... | Golgi apparatus; nucleoplasm; plasma membrane; trans-Golgi network membrane | G protein-coupled peptide receptor activity G protein-coupled receptor activity protein-hormone receptor activity transmembrane signaling receptor activity | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Golgi apparatus Leucine-rich repeat Membrane Receptor Reference proteome Repeat Signal Transducer Transmembrane Transmembrane helix | MDTSRLGVLL | MDTSRLGVLLSLPVLLQLATGGSSPRSGVLLRGCPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITE... | adenylate cyclase-activating G protein-coupled receptor signaling pathway epithelial cell proliferation involved in renal tubule morphogenesis G protein-coupled receptor signaling pathway hair follicle development inner ear development oocyte differentiation positive regulation of canonical Wnt signaling pathway regula... |
chromatin remodeling mRNA 5'-splice site recognition positive regulation of transcription by RNA polymerase II response to heat response to oxidative stress | cytosol; euchromatin; heterochromatin; nuclear periphery; nucleoplasm; nucleus | chromatin binding DNA-binding transcription factor binding RNA binding supercoiled DNA binding transcription coactivator activity | Homo sapiens | 3D-structure Alternative splicing Chromosomal rearrangement Citrullination Coiled coil Direct protein sequencing DNA-binding Host-virus interaction Isopeptide bond Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Ubl conjugation | MTRDFKPGDL | MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEE... | chromatin remodeling mRNA 5'-splice site recognition positive regulation of transcription by RNA polymerase II response to heat response to oxidative stress cytosol; euchromatin; heterochromatin; nuclear periphery; nucleoplasm; nucleus chromatin binding DNA-binding transcription factor binding RNA binding supercoiled D... |
cholesterol metabolic process negative regulation of cholesterol biosynthetic process negative regulation of fatty acid biosynthetic process regulation of cholesterol biosynthetic process SREBP signaling pathway ubiquitin-dependent ERAD pathway | endoplasmic reticulum; endoplasmic reticulum membrane; membrane raft; protein-containing complex | cholesterol binding ubiquitin protein ligase binding | Homo sapiens | Acetylation Cholesterol metabolism Direct protein sequencing Disease variant Endoplasmic reticulum Glycoprotein Hereditary spastic paraplegia Lipid metabolism Lipid-binding Membrane Neurodegeneration Reference proteome Signal-anchor Steroid metabolism Sterol metabolism Transmembrane Transmembrane helix | MNMTQARVLV | MNMTQARVLVAAVVGLVAVLLYASIHKIEEGHLAVYYRGGALLTSPSGPGYHIMLPFITTFRSVQTTLQTDEVKNVPCGTSGGVMIYIDRIEVVNMLAPYAVFDIVRNYTADYDKTLIFNKIHHELNQFCSAHTLQEVYIELFDQIDENLKQALQKDLNLMAPGLTIQAVRVTKPKIPEAIRRNFELMEAEKTKLLIAAQKQKVVEKEAETERKKAVIEAEKIAQVAKIRFQQKVMEKETEKRISEIEDAAFLAREKAKADAEYYAAHKYATSNKHKLTPEYLELKKYQAIASNSKIYFGSNIPNMFVDSSCALKYSDIR... | cholesterol metabolic process negative regulation of cholesterol biosynthetic process negative regulation of fatty acid biosynthetic process regulation of cholesterol biosynthetic process SREBP signaling pathway ubiquitin-dependent ERAD pathway endoplasmic reticulum; endoplasmic reticulum membrane; membrane raft; prote... |
chromatin remodeling regulation of cell cycle regulation of cell division regulation of DNA-templated transcription regulation of embryonic development regulation of histone acetylation regulation of transcription by RNA polymerase II regulation of tubulin deacetylation | ATAC complex; mitotic spindle; nucleoplasm; nucleus; SAGA complex; SAGA-type complex | chromatin binding DNA binding transcription coactivator activity zinc ion binding | Homo sapiens | 3D-structure Alternative splicing Chromosome DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MDRLGPFSND | MDRLGPFSNDPSDKPPCRGCSSYLMEPYIKCAECGPPPFFLCLQCFTRGFEYKKHQSDHTYEIMTSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHFINNPLFASTLLNLKQAEEAKTADTAIPFHSTDDPPRPTFDSLLSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFCSARTYDHLKKTREEERLKRTML... | chromatin remodeling regulation of cell cycle regulation of cell division regulation of DNA-templated transcription regulation of embryonic development regulation of histone acetylation regulation of transcription by RNA polymerase II regulation of tubulin deacetylation ATAC complex; mitotic spindle; nucleoplasm; nucle... |
positive regulation of DNA-templated transcription regulation of DNA repair regulation of DNA-templated transcription regulation of RNA splicing regulation of transcription by RNA polymerase II transcription by RNA polymerase II | nucleoplasm; nucleus; SAGA complex; transcription factor TFTC complex | protein heterodimerization activity transcription coactivator activity | Homo sapiens | 3D-structure Acetylation Activator Alternative splicing Direct protein sequencing Isopeptide bond Nucleus Reference proteome Transcription Transcription regulation Ubl conjugation | MNNTAASPMS | MNNTAASPMSTATSSSGRSTGKSISFATELQSMMYSLGDARRPLHETAVLVEDVVHTQLINLLQQAAEVSQLRGARVITPEDLLFLMRKDKKKLRRLLKYMFIRDYKSKIVKGIDEDDLLEDKLSGSNNANKRQKIAQDFLNSIDQTGELLAMFEDDEIDEVKQERMERAERQTRIMDSAQYAEFCESRQLSFSKKASKFRDWLDCSSMEIKPNVVAMEILAYLAYETVAQLVDLALLVRQDMVTKAGDPFSHAISATFIQYHNSAESTAACGVEAHSDAIQPCHIREAIRRYSHRIGPLSPFTNAYRRNGMAFLAC | positive regulation of DNA-templated transcription regulation of DNA repair regulation of DNA-templated transcription regulation of RNA splicing regulation of transcription by RNA polymerase II transcription by RNA polymerase II nucleoplasm; nucleus; SAGA complex; transcription factor TFTC complex protein heterodimeriz... |
cell migration regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of presynapse assembly regulation of signal transduction synaptic membrane adhesion Wnt signaling pathway | cell surface; collagen-containing extracellular matrix; external side of plasma membrane; extracellular exosome; glutamatergic synapse; Golgi lumen; lysosomal lumen; nucleus; plasma membrane; synapse | coreceptor activity | Homo sapiens | Alternative splicing Cell membrane Deafness Disease variant Glycoprotein GPI-anchor Heparan sulfate Intellectual disability Lipoprotein Membrane Phosphoprotein Proteoglycan Reference proteome Secreted Signal | MARFGLPALL | MARFGLPALLCTLAVLSAALLAAELKSKSCSEVRRLYVSKGFNKNDAPLHEINGDHLKICPQGSTCCSQEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKIS... | cell migration regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of presynapse assembly regulation of signal transduction synaptic membrane adhesion Wnt signaling pathway cell surface; collagen-containing extracellular matrix; external side of plasma membrane; extra... |
cytosolic transport mRNA splice site recognition mRNA splicing, via spliceosome negative regulation of mRNA splicing, via spliceosome regulation of DNA-templated transcription regulation of mRNA splicing, via spliceosome RNA splicing, via transesterification reactions spliceosomal tri-snRNP complex assembly | axon terminus; cytoplasm; cytosol; dendrite; neuronal cell body; nuclear speck; nucleoplasm; nucleus | RNA binding RS domain binding unfolded protein binding | Homo sapiens | Alternative splicing Cytoplasm mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome RNA-binding | MSRYLRPPNT | MSRYLRPPNTSLFVRNVADDTRSEDLRREFGRYGPIVDVYVPLDFYTRRPRGFAYVQFEDVRDAEDALHNLDRKWICGRQIEIQFAQGDRKTPNQMKAKEGRNVYSSSRYDDYDRYRRSRSRSYERRRSRSRSFDYNYRRSYSPRNSRPTGRPRRSRSHSDNDRFKHRNRSFSRSKSNSRSRSKSQPKKEMKAKSRSRSASHTKTRGTSKTDSKTHYKSGSRYEKESRKKEPPRSKSQSRSQSRSRSKSRSRSWTSPKSSGH | cytosolic transport mRNA splice site recognition mRNA splicing, via spliceosome negative regulation of mRNA splicing, via spliceosome regulation of DNA-templated transcription regulation of mRNA splicing, via spliceosome RNA splicing, via transesterification reactions spliceosomal tri-snRNP complex assembly axon termin... |
animal organ morphogenesis DNA replication preinitiation complex assembly negative regulation of cell cycle negative regulation of DNA replication negative regulation of DNA-templated DNA replication negative regulation of DNA-templated transcription positive regulation of chromatin binding regulation of DNA replicatio... | cytoplasm; cytosol; nucleoplasm; nucleus; transcription repressor complex | chromatin binding DNA-binding transcription factor binding histone deacetylase binding transcription corepressor activity | Homo sapiens | 3D-structure Acetylation Cell cycle Coiled coil Cytoplasm Disease variant DNA replication inhibitor Dwarfism Nucleus Phosphoprotein Reference proteome | MNPSMKQKQE | MNPSMKQKQEEIKENIKNSSVPRRTLKMIQPSASGSLVGRENELSAGLSKRKHRNDHLTSTTSSPGVIVPESSENKNLGGVTQESFDLMIKENPSSQYWKEVAEKRRKALYEALKENEKLHKEIEQKDNEIARLKKENKELAEVAEHVQYMAELIERLNGEPLDNFESLDNQEFDSEEETVEDSLVEDSEIGTCAEGTVSSSTDAKPCI | animal organ morphogenesis DNA replication preinitiation complex assembly negative regulation of cell cycle negative regulation of DNA replication negative regulation of DNA-templated DNA replication negative regulation of DNA-templated transcription positive regulation of chromatin binding regulation of DNA replicatio... |
brain development glycosylation lysosomal lumen acidification lysosome organization neurogenesis neuron maturation positive regulation of GTP binding protein catabolic process retrograde transport, endosome to Golgi signal peptide processing visual perception | cytosol; endoplasmic reticulum; extracellular exosome; Golgi apparatus; lysosomal membrane; lysosome; membrane; perinuclear region of cytoplasm; vacuolar lumen | bis(monoacylglycero)phosphate synthase activity hydrolase activity, acting on glycosyl bonds mannose binding palmitoyl-CoA hydrolase activity | Homo sapiens | Disease variant Epilepsy Glycoprotein Lysosome Membrane Neurodegeneration Neuronal ceroid lipofuscinosis Reference proteome Signal-anchor Transmembrane Transmembrane helix | MAQEVDTAQG | MAQEVDTAQGAEMRRGAGAARGRASWCWALALLWLAVVPGWSRVSGIPSRRHWPVPYKRFDFRPKPDPYCQAKYTFCPTGSPIPVMEGDDDIEVFRLQAPVWEFKYGDLLGHLKIMHDAIGFRSTLTGKNYTMEWYELFQLGNCTFPHLRPEMDAPFWCNQGAACFFEGIDDVHWKENGTLVQVATISGNMFNQMAKWVKQDNETGIYYETWNVKASPEKGAETWFDSYDCSKFVLRTFNKLAEFGAEFKNIETNYTRIFLYSGEPTYLGNETSVFGPTGNKTLGLAIKRFYYPFKPHLPTKEFLLSLLQIFDAVIVHKQ... | brain development glycosylation lysosomal lumen acidification lysosome organization neurogenesis neuron maturation positive regulation of GTP binding protein catabolic process retrograde transport, endosome to Golgi signal peptide processing visual perception cytosol; endoplasmic reticulum; extracellular exosome; Golgi... |
axonal transport of mitochondrion cellular heat acclimation endodermal cell differentiation negative regulation of transcription by RNA polymerase II | axon cytoplasm; cytosol; nucleoplasm; nucleus | identical protein binding transcription corepressor activity | Homo sapiens | 3D-structure Nucleus Reference proteome | MAETDPKTVQ | MAETDPKTVQDLTSVVQTLLQQMQDKFQTMSDQIIGRIDDMSSRIDDLEKNIADLMTQAGVEELESENKIPATQKS | axonal transport of mitochondrion cellular heat acclimation endodermal cell differentiation negative regulation of transcription by RNA polymerase II axon cytoplasm; cytosol; nucleoplasm; nucleus identical protein binding transcription corepressor activity Homo sapiens 3D-structure Nucleus Reference proteome MAETDPKTVQ... |
axon ensheathment bicellular tight junction assembly calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell adhesion spermatogenesis tight junction assembly | axon; basal part of cell; bicellular tight junction; cell junction; lipid droplet; neurofilament; plasma membrane; tight junction | identical protein binding structural molecule activity | Homo sapiens | Cell junction Cell membrane Leukodystrophy Membrane Phosphoprotein Reference proteome Tight junction Transmembrane Transmembrane helix | MVATCLQVVG | MVATCLQVVGFVTSFVGWIGVIVTTSTNDWVVTCGYTIPTCRKLDELGSKGLWADCVMATGLYHCKPLVDILILPGYVQACRALMIAASVLGLPAILLLLTVLPCIRMGQEPGVAKYRRAQLAGVLLILLALCALVATIWFPVCAHRETTIVSFGYSLYAGWIGAVLCLVGGCVILCCAGDAQAFGENRFYYTAGSSSPTHAKSAHV | axon ensheathment bicellular tight junction assembly calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell adhesion spermatogenesis tight junction assembly axon; basal part of cell; bicellular tight junction; cell junction; lipid droplet; neurofilament; plasma membrane; tight junction ... |
fatty acid beta-oxidation fatty acid catabolic process | cytosol; intracellular membrane-bounded organelle; membrane; mitochondrion; peroxisomal matrix; peroxisome | delta(3)-delta(2)-enoyl-CoA isomerase activity fatty-acyl-CoA binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Isomerase Mitochondrion Peroxisome Phosphoprotein Reference proteome Transit peptide | MAMAYLAWRL | MAMAYLAWRLARRSCPSSLQVTSFPVVQLHMNRTAMRASQKDFENSMNQVKLLKKDPGNEVKLKLYALYKQATEGPCNMPKPGVFDLINKAKWDAWNALGSLPKEAARQNYVDLVSSLSPSLESSSQVEPGTDRKSTGFETLVVTSEDGITKIMFNRPKKKNAINTEMYHEIMRALKAASKDDSIITVLTGNGDYYSSGNDLTNFTDIPPGGVEEKAKNNAVLLREFVGCFIDFPKPLIAVVNGPAVGISVTLLGLFDAVYASDRATFHTPFSHLGQSPEGCSSYTFPKIMSPAKATEMLIFGKKLTAGEACAQGLVTEV... | fatty acid beta-oxidation fatty acid catabolic process cytosol; intracellular membrane-bounded organelle; membrane; mitochondrion; peroxisomal matrix; peroxisome delta(3)-delta(2)-enoyl-CoA isomerase activity fatty-acyl-CoA binding Homo sapiens 3D-structure Acetylation Alternative splicing Isomerase Mitochondrion Perox... |
mRNA processing regulation of alternative mRNA splicing, via spliceosome | nucleoplasm; nucleus; protein-containing complex | identical protein binding mRNA binding protein domain specific binding RNA binding SH3 domain binding | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Host-virus interaction Isopeptide bond mRNA processing Nucleus Phosphoprotein Reference proteome RNA-binding SH3-binding Transcription Transcription regulation Ubl conjugation | MEEKYLPELM | MEEKYLPELMAEKDSLDPSFTHALRLVNQEIEKFQKGEGKDEEKYIDVVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKPTLRTRGVPAPAITRGRGGVTARPVGVVVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPPTQETYGEYDYDDGYGTAYDEQSYDSYDNSYSTPAQSGADYYDYGHGLSEETYDSYGQEE... | mRNA processing regulation of alternative mRNA splicing, via spliceosome nucleoplasm; nucleus; protein-containing complex identical protein binding mRNA binding protein domain specific binding RNA binding SH3 domain binding Homo sapiens 3D-structure Alternative splicing Direct protein sequencing Host-virus interaction ... |
chromatin organization intracellular estrogen receptor signaling pathway mitotic cell cycle negative regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription positive regulation of gene expression regulation of cell cycle regulation of cell division regulation of DNA repair re... | ATAC complex; mitotic spindle; nucleoplasm; nucleus; SAGA complex; transcription factor TFTC complex | nuclear receptor binding nuclear receptor coactivator activity protein domain specific binding transcription coactivator activity | Homo sapiens | Acetylation Alternative splicing Coiled coil Isopeptide bond Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Ubl conjugation | MSELKDCPLQ | MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGRPKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKE... | chromatin organization intracellular estrogen receptor signaling pathway mitotic cell cycle negative regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription positive regulation of gene expression regulation of cell cycle regulation of cell division regulation of DNA repair re... |
positive regulation of DNA-templated transcription regulation of DNA repair regulation of DNA-templated transcription regulation of RNA splicing regulation of somatic stem cell population maintenance regulation of transcription by RNA polymerase II transcription by RNA polymerase II | cytoplasmic ribonucleoprotein granule; histone acetyltransferase complex; nuclear speck; nucleus; SAGA complex; transcription factor TFTC complex | transcription coactivator activity | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Nucleus Reference proteome Repeat Transcription Transcription regulation WD repeat | MKRVRTEQIQ | MKRVRTEQIQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSAAPCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNLVQNSPKSTVESFYSRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQSDNNTALCKVLTLHIHLDVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQNEAALEVLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDI... | positive regulation of DNA-templated transcription regulation of DNA repair regulation of DNA-templated transcription regulation of RNA splicing regulation of somatic stem cell population maintenance regulation of transcription by RNA polymerase II transcription by RNA polymerase II cytoplasmic ribonucleoprotein granul... |
negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II spinal cord development | chromosome; cytosol; ESC/E(Z) complex; nucleoplasm; nucleus | chromatin binding enzyme activator activity histone methyltransferase activity identical protein binding transcription corepressor binding | Homo sapiens | 3D-structure Acetylation Alternative initiation Alternative splicing Chromatin regulator Chromosome Disease variant Host-virus interaction Methylation Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation WD repeat | MSEREVSTAP | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLIL... | negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II spinal cord development chromosome; cytosol; ESC/E(Z) complex; nucleoplasm; nucleus chromatin binding enzyme activator activity histone methyltransferase activity identical protein binding transcription corepres... |
chromatin organization DNA integration mitotic nuclear membrane reassembly negative regulation of cGAS/STING signaling pathway negative regulation of innate immune response negative regulation of protein ADP-ribosylation negative regulation of type I interferon production negative regulation of viral genome replication... | chromatin; condensed chromosome; cytoplasm; cytosol; nuclear envelope; nucleoplasm; nucleus | double-stranded DNA binding identical protein binding protein homodimerization activity | Homo sapiens | 3D-structure Acetylation Chromosome Cytoplasm Disease variant DNA-binding Host-virus interaction Nucleus Phosphoprotein Reference proteome | MTTSQKHRDF | MTTSQKHRDFVAEPMGEKPVGSLAGIGEVLGKKLEERGFDKAYVVLGQFLVLKKDEDLFREWLKDTCGANAKQSRDCFGCLREWCDAFL | chromatin organization DNA integration mitotic nuclear membrane reassembly negative regulation of cGAS/STING signaling pathway negative regulation of innate immune response negative regulation of protein ADP-ribosylation negative regulation of type I interferon production negative regulation of viral genome replication... |
CRD-mediated mRNA stabilization IRES-dependent viral translational initiation male gonad development negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay nuclear-transcribed mRNA catabolic process, no-go decay positive regulation of cytoplasmic translation regulation of trans... | CRD-mediated mRNA stability complex; cytoplasmic stress granule; cytosol; Golgi apparatus; mCRD-mediated mRNA stability complex; P-body; plasma membrane | RISC complex binding RNA binding RNA stem-loop binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Isopeptide bond Phosphoprotein Reference proteome Repeat RNA-binding Ubl conjugation | MSFDPNLLHN | MSFDPNLLHNNGHNGYPNGTSAALRETGVIEKLLTSYGFIQCSERQARLFFHCSQYNGNLQDLKVGDDVEFEVSSDRRTGKPIAVKLVKIKQEILPEERMNGQVVCAVPHNLESKSPAAPGQSPTGSVCYERNGEVFYLTYTPEDVEGNVQLETGDKINFVIDNNKHTGAVSARNIMLLKKKQARCQGVVCAMKEAFGFIERGDVVKEIFFHYSEFKGDLETLQPGDDVEFTIKDRNGKEVATDVRLLPQGTVIFEDISIEHFEGTVTKVIPKVPSKNQNDPLPGRIKVDFVIPKELPFGDKDTKSKVTLLEGDHVRFNI... | CRD-mediated mRNA stabilization IRES-dependent viral translational initiation male gonad development negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay nuclear-transcribed mRNA catabolic process, no-go decay positive regulation of cytoplasmic translation regulation of trans... |
mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome RNA splicing | nuclear speck; nucleoplasm; nucleus; precatalytic spliceosome; U2-type precatalytic spliceosome | proline-rich region binding RNA binding zinc ion binding | Homo sapiens | 3D-structure Alternative splicing Metal-binding mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Repeat Spliceosome Zinc Zinc-finger | MADYWKSQPK | MADYWKSQPKKFCDYCKCWIADNRPSVEFHERGKNHKENVAKRISEIKQKSLDKAKEEEKASKEFAAMEAAALKAYQEDLKRLGLESEILEPSITPVTSTIPPTSTSNQQKEKKEKKKRKKDPSKGRWVEGITSEGYHYYYDLISGASQWEKPEGFQGDLKKTAVKTVWVEGLSEDGFTYYYNTETGESRWEKPDDFIPHTSDLPSSKVNENSLGTLDESKSSDSHSDSDGEQEAEEGGVSTETEKPKIKFKEKNKNSDGGSDPETQKEKSIQKQNSLGSNEEKSKTLKKSNPYGEWQEIKQEVESHEEVDLELPSTENE... | mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome RNA splicing nuclear speck; nucleoplasm; nucleus; precatalytic spliceosome; U2-type precatalytic spliceosome proline-rich region binding RNA binding zinc ion binding Homo sapiens 3D-structure Alternative splicing Metal-binding mRNA processing mRNA splici... |
exocytosis intracellular protein transport membrane fusion synaptic vesicle fusion to presynaptic active zone membrane vesicle docking | endomembrane system; Golgi apparatus; plasma membrane; presynaptic active zone membrane; SNARE complex; synaptic vesicle | SNAP receptor activity SNARE binding | Homo sapiens | Coiled coil Familial hemophagocytic lymphohistiocytosis Golgi apparatus Membrane Protein transport Reference proteome Transport | MKDRLAELLD | MKDRLAELLDLSKQYDQQFPDGDDEFDSPHEDIVFETDHILESLYRDIRDIQDENQLLVADVKRLGKQNARFLTSMRRLSSIKRDTNSIAKAIKARGEVIHCKLRAMKELSEAAEAQHGPHSAVARISRAQYNALTLTFQRAMHDYNQAEMKQRDNCKIRIQRQLEIMGKEVSGDQIEDMFEQGKWDVFSENLLADVKGARAALNEIESRHRELLRLESRIRDVHELFLQMAVLVEKQADTLNVIELNVQKTVDYTGQAKAQVRKAVQYEEKNPCRTLCCFCCPCLK | exocytosis intracellular protein transport membrane fusion synaptic vesicle fusion to presynaptic active zone membrane vesicle docking endomembrane system; Golgi apparatus; plasma membrane; presynaptic active zone membrane; SNARE complex; synaptic vesicle SNAP receptor activity SNARE binding Homo sapiens Coiled coil Fa... |
positive regulation of canonical Wnt signaling pathway | cytoplasm; nucleus; ribonucleoprotein complex | DNA binding mRNA binding | Homo sapiens | Alternative splicing DNA-binding Nucleus Phosphoprotein Reference proteome | MASKPAAGKS | MASKPAAGKSRGEKRKRVVLTLKEKIDICTRLEKGESRKALMQEYNVGMSTLYDIRAHKAQLLRFFASSDSNKALEQRRTLHTPKLEHLDRVLYEWFLGKRSEGVPVSGPMLIEKAKDFYEQMQLTEPCVFSGGWLWRFKARHGIKKLDASSEKQSADHQAAEQFCAFFRSLAAEHGLSAEQVYNADETGLFWRCLPNPTPEGGAVPGPKQGKDRLTVLMCANATGSHRLKPLAIGKCSGPRAFKGIQHLPVAYKAQGNAWVDKEIFSDWFHHIFVPSVREHFRTIGLPEDSKAVLLLDSSRAHPQEAELVSSNVFTIFL... | positive regulation of canonical Wnt signaling pathway cytoplasm; nucleus; ribonucleoprotein complex DNA binding mRNA binding Homo sapiens Alternative splicing DNA-binding Nucleus Phosphoprotein Reference proteome MASKPAAGKS MASKPAAGKSRGEKRKRVVLTLKEKIDICTRLEKGESRKALMQEYNVGMSTLYDIRAHKAQLLRFFASSDSNKALEQRRTLHTPKLEHLDRVLYE... |
cellular response to oxidative stress immune response middle ear morphogenesis miRNA processing negative regulation of cell population proliferation outer ear morphogenesis positive regulation of intrinsic apoptotic signaling pathway pre-miRNA processing protein stabilization regulation of regulatory ncRNA processing r... | cytoplasm; cytosol; membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; RISC complex; RISC-loading complex | double-stranded RNA binding enzyme activator activity enzyme binding identical protein binding pre-miRNA binding protein homodimerization activity RNA binding siRNA binding | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Disease variant Dystonia Host-virus interaction Parkinsonism Phosphoprotein Reference proteome Repeat RNA-binding RNA-mediated gene silencing | MSQSRHRAEA | MSQSRHRAEAPPLEREDSGTFSLGKMITAKPGKTPIQVLHEYGMKTKNIPVYECERSDVQIHVPTFTFRVTVGDITCTGEGTSKKLAKHRAAEAAINILKANASICFAVPDPLMPDPSKQPKNQLNPIGSLQELAIHHGWRLPEYTLSQEGGPAHKREYTTICRLESFMETGKGASKKQAKRNAAEKFLAKFSNISPENHISLTNVVGHSLGCTWHSLRNSPGEKINLLKRSLLSIPNTDYIQLLSEIAKEQGFNITYLDIDELSANGQYQCLAELSTSPITVCHGSGISCGNAQSDAAHNALQYLKIIAERK | cellular response to oxidative stress immune response middle ear morphogenesis miRNA processing negative regulation of cell population proliferation outer ear morphogenesis positive regulation of intrinsic apoptotic signaling pathway pre-miRNA processing protein stabilization regulation of regulatory ncRNA processing r... |
mitochondrial translational termination | mitochondrion | translation release factor activity translation release factor activity, codon specific | Homo sapiens | 3D-structure Alternative splicing Methylation Mitochondrion Protein biosynthesis Reference proteome Transit peptide | MNRHLCVWLF | MNRHLCVWLFRHPSLNGYLQCHIQLHSHQFRQIHLDTRLQVFRQNRNCILHLLSKNWSRRYCHQDTKMLWKHKALQKYMENLSKEYQTLEQCLQHIPVNEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGRTTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEVGLSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGAGGQHVNKTDS... | mitochondrial translational termination mitochondrion translation release factor activity translation release factor activity, codon specific Homo sapiens 3D-structure Alternative splicing Methylation Mitochondrion Protein biosynthesis Reference proteome Transit peptide MNRHLCVWLF MNRHLCVWLFRHPSLNGYLQCHIQLHSHQFRQIHLDTR... |
defense response to virus innate immune response neuropeptide signaling pathway transcription by RNA polymerase III transcription initiation at RNA polymerase III promoter | acrosomal vesicle; cytosol; DNA polymerase III complex; nucleoplasm; plasma membrane; RNA polymerase III complex | calcitonin gene-related peptide receptor activity DNA-directed 5'-3' RNA polymerase activity nucleotide binding | Homo sapiens | 3D-structure Alternative splicing Antiviral defense Cell membrane DNA-directed RNA polymerase Immunity Innate immunity Membrane Nucleus Reference proteome Transcription | MEVKDANSAL | MEVKDANSALLSNYEVFQLLTDLKEQRKESGKNKHSSGQQNLNTITYETLKYISKTPCRHQSPEIVREFLTALKSHKLTKAEKLQLLNHRPVTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAEPEAEQKKNTNSNVAMDEEDPA | defense response to virus innate immune response neuropeptide signaling pathway transcription by RNA polymerase III transcription initiation at RNA polymerase III promoter acrosomal vesicle; cytosol; DNA polymerase III complex; nucleoplasm; plasma membrane; RNA polymerase III complex calcitonin gene-related peptide rec... |
axon guidance inflammatory response interleukin-1-mediated signaling pathway intracellular signal transduction negative regulation of cytokine production negative regulation of DNA-templated transcription positive regulation of CREB transcription factor activity positive regulation of NF-kappaB transcription factor act... | cytoplasm; nucleoplasm; nucleus | ATP binding histone H2AS1 kinase activity histone H3S10 kinase activity histone H3S28 kinase activity magnesium ion binding protein serine kinase activity protein serine/threonine kinase activity protein tyrosine kinase activity | Homo sapiens | 3D-structure Alternative splicing ATP-binding Cytoplasm Inflammatory response Kinase Magnesium Metal-binding Nucleotide-binding Nucleus Phosphoprotein Reference proteome Repeat Serine/threonine-protein kinase Stress response Transferase Ubl conjugation | MEEEGGSSGG | MEEEGGSSGGAAGTSADGGDGGEQLLTVKHELRTANLTGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATIVQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRERFTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETERAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEISRRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQK... | axon guidance inflammatory response interleukin-1-mediated signaling pathway intracellular signal transduction negative regulation of cytokine production negative regulation of DNA-templated transcription positive regulation of CREB transcription factor activity positive regulation of NF-kappaB transcription factor act... |
positive regulation of transcription by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II positive regulation of transcription initiation by RNA polymerase II protein ubiquitination regulation of transcription by RNA polymerase II RNA polymerase II preinitiation complex assembly som... | core mediator complex; mediator complex; membrane; nucleoplasm; nucleus; ubiquitin ligase complex | DNA binding transcription coactivator activity transcription coactivator binding ubiquitin protein ligase activity | Homo sapiens | 3D-structure Acetylation Activator Alternative splicing Direct protein sequencing Isopeptide bond Nucleus Reference proteome Transcription Transcription regulation Ubl conjugation | MAAVDIRDNL | MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHLNQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVRPKAKRKEEPSSIFQRQRVDALLLDLRQKFPPKFVQLKPGEKPVPVDQTKKEAEPIPETVKPEEKETTKNVQQTVSAKGPPEKRMRLQ | positive regulation of transcription by RNA polymerase II positive regulation of transcription elongation by RNA polymerase II positive regulation of transcription initiation by RNA polymerase II protein ubiquitination regulation of transcription by RNA polymerase II RNA polymerase II preinitiation complex assembly som... |
aorta morphogenesis axial mesoderm development cardiac right ventricle morphogenesis cellular response to cytokine stimulus determination of left/right asymmetry in lateral mesoderm embryonic heart tube anterior/posterior pattern specification heart looping hepatocyte differentiation negative regulation of androgen rec... | activin responsive factor complex; chromatin; nucleus; transcription regulator complex | bHLH transcription factor binding cis-regulatory region sequence-specific DNA binding co-SMAD binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor binding nuclear androgen receptor binding ... | Homo sapiens | 3D-structure Activator DNA-binding Nucleus Reference proteome Transcription Transcription regulation | MGPCSGSRLG | MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLAMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAFAKDLGPYVLHGRPYRPPSPPPPPSEGFSIKSLLGGSGEGAPWPGLAPQSSPVPAGTGNSGEEAVPTPPLPSSERPLWPLCPLPGPTRVEGETVQGGAIGPSTLSPEPRAWPLHLLQGTAVPGGRSSGGHRASLWGQLPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGVAPETRGP... | aorta morphogenesis axial mesoderm development cardiac right ventricle morphogenesis cellular response to cytokine stimulus determination of left/right asymmetry in lateral mesoderm embryonic heart tube anterior/posterior pattern specification heart looping hepatocyte differentiation negative regulation of androgen rec... |
antimicrobial humoral immune response mediated by antimicrobial peptide biological process involved in interaction with host defense response to Gram-positive bacterium detection of bacterium innate immune response killing of cells of another organism negative regulation of inflammatory response negative regulation of ... | extracellular exosome; extracellular region; extracellular space; phagocytic vesicle lumen; specific granule lumen; tertiary granule lumen | Hsp70 protein binding molecular adaptor activity N-acetylmuramoyl-L-alanine amidase activity peptidoglycan binding peptidoglycan immune receptor activity receptor ligand activity zinc ion binding | Homo sapiens | 3D-structure Antibiotic Antimicrobial Disulfide bond Glycoprotein Immunity Innate immunity Pyrrolidone carboxylic acid Reference proteome Secreted Signal | MSRRSMLLAW | MSRRSMLLAWALPSLLRLGAAQETEDPACCSPIVPRNEWKALASECAQHLSLPLRYVVVSHTAGSSCNTPASCQQQARNVQHYHMKTLGWCDVGYNFLIGEDGLVYEGRGWNFTGAHSGHLWNPMSIGISFMGNYMDRVPTPQAIRAAQGLLACGVAQGALRSNYVLKGHRDVQRTLSPGNQLYHLIQNWPHYRSP | antimicrobial humoral immune response mediated by antimicrobial peptide biological process involved in interaction with host defense response to Gram-positive bacterium detection of bacterium innate immune response killing of cells of another organism negative regulation of inflammatory response negative regulation of ... |
amino acid metabolic process biosynthetic process threonine catabolic process | mitochondrial inner membrane; mitochondrion; nuclear speck; nucleoplasm; nucleus | glycine C-acetyltransferase activity pyridoxal phosphate binding | Homo sapiens | Acetylation Acyltransferase Alternative splicing Mitochondrion Nucleus Pyridoxal phosphate Reference proteome Transferase Transit peptide | MWPGNAWRAA | MWPGNAWRAALFWVPRGRRAQSALAQLRGILEGELEGIRGAGTWKSERVITSRQGPHIRVDGVSGGILNFCANNYLGLSSHPEVIQAGLQALEEFGAGLSSVRFICGTQSIHKNLEAKIARFHQREDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLEAKLQEAQKHRLRLVATDGAFSMDGDIAPLQEICCLASRYGALVFMDECHATGFLGPTGRGTDELLGVMDQVTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYLFSNSLPPAVVGCASKALDLLMGSNTIV... | amino acid metabolic process biosynthetic process threonine catabolic process mitochondrial inner membrane; mitochondrion; nuclear speck; nucleoplasm; nucleus glycine C-acetyltransferase activity pyridoxal phosphate binding Homo sapiens Acetylation Acyltransferase Alternative splicing Mitochondrion Nucleus Pyridoxal ph... |
epithelial cilium movement involved in extracellular fluid movement filopodium assembly neuron projection extension sperm axoneme assembly | acrosomal vesicle; axoneme; extracellular region; microtubule; microtubule cytoskeleton; nucleus; sperm principal piece | microtubule binding | Homo sapiens | Alternative splicing Cell projection Cilium Cilium biogenesis/degradation Cytoplasm Cytoskeleton Flagellum Microtubule Reference proteome Repeat | MSQRQVLQVF | MSQRQVLQVFEQYQKARTQFVQMVAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGRLANYNDDLAEAVVKCDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWALRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAHLAQMILNPDAKLKHQILSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTLIREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYV... | epithelial cilium movement involved in extracellular fluid movement filopodium assembly neuron projection extension sperm axoneme assembly acrosomal vesicle; axoneme; extracellular region; microtubule; microtubule cytoskeleton; nucleus; sperm principal piece microtubule binding Homo sapiens Alternative splicing Cell pr... |
gliogenesis intracellular calcium ion homeostasis intracellular phosphate ion homeostasis parathyroid gland development regulation of transcription by RNA polymerase II transcription by RNA polymerase II | chromatin; nucleus | DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Developmental protein Disease variant DNA-binding Metal-binding Nucleus Reference proteome Transcription Transcription regulation Zinc | MPAAAVQEAV | MPAAAVQEAVGVCSYGMQLSWDINDPQMPQELALFDQFREWPDGYVRFIYSSDEKKAQRHLSGWAMRNTNNHNGHILKKSCLGVVVCTQACTLPDGSRLQLRPAICDKARLKQQKKACPNCHSALELIPCRGHSGYPVTNFWRLDGNAIFFQAKGVHDHPRPESKSETEARRSAIKRQMASFYQPQKKRIRESEAEENQDSSGHFSNIPPLENPEDFDIVTETSFPIPGQPCPSFPKSDVYKATCDLATFQGDKMPPFQKYSSPRIYLPRPPCSYELANPGYTNSSPYPTLYKDSTSIPNDTDWVHLNTLQCNVNSYSSY... | gliogenesis intracellular calcium ion homeostasis intracellular phosphate ion homeostasis parathyroid gland development regulation of transcription by RNA polymerase II transcription by RNA polymerase II chromatin; nucleus DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding ... |
cell cycle circadian behavior circadian regulation of gene expression entrainment of circadian clock by photoperiod locomotor rhythm muscle organ development negative regulation of transcription by RNA polymerase II positive regulation of mitotic cell cycle protein deubiquitination protein stabilization proteolysis reg... | centrosome; cytoplasm; membrane; nucleoplasm; perinuclear region of cytoplasm | cyclin binding cysteine-type deubiquitinase activity cysteine-type endopeptidase activity identical protein binding metal ion binding ubiquitin protein ligase binding | Homo sapiens | 3D-structure Alternative splicing Biological rhythms Cell cycle Cytoplasm Hydrolase Membrane Metal-binding Myogenesis Nucleus Protease Reference proteome Thiol protease Ubl conjugation pathway Zinc | MSQLSSTLKR | MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKLGFKPVPTSSFLTRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNNCLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTRKELCTLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETGKGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEFAK... | cell cycle circadian behavior circadian regulation of gene expression entrainment of circadian clock by photoperiod locomotor rhythm muscle organ development negative regulation of transcription by RNA polymerase II positive regulation of mitotic cell cycle protein deubiquitination protein stabilization proteolysis reg... |
chromatin remodeling rRNA processing rRNA transcription | actin cytoskeleton; cytoplasm; cytosol; nucleolus; nucleoplasm | chromatin binding histone binding RNA binding | Homo sapiens | Acetylation Chaperone Direct protein sequencing Methylation Nucleus Phosphoprotein Reference proteome | MAAGTAAALA | MAAGTAAALAFLSQESRTRAGGVGGLRVPAPVTMDSFFFGCELSGHTRSFTFKVEEEDDAEHVLALTMLCLTEGAKDECNVVEVVARNHDHQEIAVPVANLKLSCQPMLSLDDFQLQPPVTFRLKSGSGPVRITGRHQIVTMSNDVSEEESEEEEEDSDEEEVELCPILPAKKQGGRP | chromatin remodeling rRNA processing rRNA transcription actin cytoskeleton; cytoplasm; cytosol; nucleolus; nucleoplasm chromatin binding histone binding RNA binding Homo sapiens Acetylation Chaperone Direct protein sequencing Methylation Nucleus Phosphoprotein Reference proteome MAAGTAAALA MAAGTAAALAFLSQESRTRAGGVGGLRVP... |
fatty acid metabolic process fatty acid transport negative regulation of Golgi to plasma membrane protein transport protein depalmitoylation | cell surface; cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; nuclear membrane; nucleoplasm; plasma membrane | carboxylic ester hydrolase activity lipase activity lysophospholipase activity palmitoyl-(protein) hydrolase activity phospholipase activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Cell membrane Cytoplasm Endoplasmic reticulum Fatty acid metabolism Hydrolase Lipid metabolism Membrane Nucleus Reference proteome | MCGNNMSTPL | MCGNNMSTPLPAIVPAARKATAAVIFLHGLGDTGHGWAEAFAGIRSSHIKYICPHAPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIKQAAENIKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFPQGPIGGANRDISILQCHGDCDPLVPLMFGSLTVEKLKTLVNPANVTFKTYEGMMHSSCQQEMMDVKQFIDKLLPPID | fatty acid metabolic process fatty acid transport negative regulation of Golgi to plasma membrane protein transport protein depalmitoylation cell surface; cytoplasm; cytosol; endoplasmic reticulum; extracellular exosome; nuclear membrane; nucleoplasm; plasma membrane carboxylic ester hydrolase activity lipase activity ... |
anterior/posterior axis specification determination of left/right symmetry heart morphogenesis negative regulation of transcription by RNA polymerase II transforming growth factor beta receptor signaling pathway | extracellular space | cytokine activity growth factor activity transforming growth factor beta receptor binding | Homo sapiens | Cytokine Developmental protein Disulfide bond Glycoprotein Growth factor Reference proteome Secreted Signal | MQPLWLCWAL | MQPLWLCWALWVLPLASPGAALTGEQLLGSLLRQLQLKEVPTLDRADMEELVIPTHVRAQYVALLQRSHGDRSRGKRFSQSFREVAGRFLALEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSARARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLGDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAENWVLEPPGFLAYECVGTCRQPPEALAFKWPFLGPRQCIASE... | anterior/posterior axis specification determination of left/right symmetry heart morphogenesis negative regulation of transcription by RNA polymerase II transforming growth factor beta receptor signaling pathway extracellular space cytokine activity growth factor activity transforming growth factor beta receptor bindin... |
ribosomal small subunit assembly | cytosol; mitochondrial inner membrane; mitochondrial matrix; mitochondrion | GTP binding ribosomal small subunit binding RNA binding rRNA binding | Homo sapiens | 3D-structure Alternative splicing Deafness Disease variant GTP-binding Membrane Mitochondrion Mitochondrion inner membrane Nucleotide-binding Phosphoprotein Reference proteome Ribosome biogenesis RNA-binding rRNA-binding Transit peptide | MAAPSWRGAR | MAAPSWRGARLVQSVLRVWQVGPHVARERVIPFSSLLGFQRRCVSCVAGSAFSGPRLASASRSNGQGSALDHFLGFSQPDSSVTPCVPAVSMNRDEQDVLLVHHPDMPENSRVLRVVLLGAPNAGKSTLSNQLLGRKVFPVSRKVHTTRCQALGVITEKETQVILLDTPGIISPGKQKRHHLELSLLEDPWKSMESADLVVVLVDVSDKWTRNQLSPQLLRCLTKYSQIPSVLVMNKVDCLKQKSVLLELTAALTEGVVNGKKLKMRQAFHSHPGTHCPSPAVKDPNTQSVGNPQRIGWPHFKEIFMLSALSQEDVKTLK... | ribosomal small subunit assembly cytosol; mitochondrial inner membrane; mitochondrial matrix; mitochondrion GTP binding ribosomal small subunit binding RNA binding rRNA binding Homo sapiens 3D-structure Alternative splicing Deafness Disease variant GTP-binding Membrane Mitochondrion Mitochondrion inner membrane Nucleot... |
decidualization extrinsic apoptotic signaling pathway via death domain receptors negative regulation of protein catabolic process negative regulation of transcription of nucleolar large rRNA by RNA polymerase I regulation of apoptotic process spermatogenesis | cytoplasm; nucleolus | DNA binding | Homo sapiens | Alternative splicing Apoptosis Cytoplasm DNA-binding Nucleus Reference proteome Repressor Transcription Transcription regulation Ubl conjugation | MAGLKRRASQ | MAGLKRRASQVWPEEHGEQEHGLYSLHRMFDIVGTHLTHRDVRVLSFLFVDVIDDHERGLIRNGRDFLLALERQGRCDESNFRQVLQLLRIITRHDLLPYVTLKRRRAVCPDLVDKYLEETSIRYVTPRALSDPEPRPPQPSKTVPPHYPVVCCPTSGPQMCSKRPARGRATLGSQRKRRKSVTPDPKEKQTCDIRLRVRAEYCQHETALQGNVFSNKQDPLERQFERFNQANTILKSRDLGSIICDIKFSELTYLDAFWRDYINGSLLEALKGVFITDSLKQAVGHEAIKLLVNVDEEDYELGRQKLLRNLMLQALP | decidualization extrinsic apoptotic signaling pathway via death domain receptors negative regulation of protein catabolic process negative regulation of transcription of nucleolar large rRNA by RNA polymerase I regulation of apoptotic process spermatogenesis cytoplasm; nucleolus DNA binding Homo sapiens Alternative spl... |
adaptive immune response aorta development artery morphogenesis cell fate commitment coronary vasculature development eye photoreceptor cell development gene expression germ cell development heart valve development innate immune response intestinal epithelial cell development kidney development maternal placenta develo... | cytoplasm; nucleolus; nucleoplasm; nucleus | DNA-binding transcription factor activity DNA-binding transcription repressor activity, RNA polymerase II-specific histone methyltransferase binding metal ion binding methyltransferase activity promoter-specific chromatin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific do... | Homo sapiens | 3D-structure Adaptive immunity Alternative splicing Cytoplasm DNA-binding Immunity Innate immunity Isopeptide bond Metal-binding Methyltransferase Nucleus Reference proteome Repeat Repressor S-adenosyl-L-methionine Transcription Transcription regulation Transferase Ubl conjugation Zinc Zinc-finger | MLDICLEKRV | MLDICLEKRVGTTLAAPKCNSSTVRFQGLAEGTKGTMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQTQSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPIRAPLPEDFLKASLAYGIER... | adaptive immune response aorta development artery morphogenesis cell fate commitment coronary vasculature development eye photoreceptor cell development gene expression germ cell development heart valve development innate immune response intestinal epithelial cell development kidney development maternal placenta develo... |
negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel regulation of skeletal muscle contraction by calcium ion signaling | I band; plasma membrane; T-tubule | calcium channel regulator activity calmodulin binding GTP binding GTPase activity transmembrane transporter binding | Homo sapiens | 3D-structure Calmodulin-binding GTP-binding Nucleotide-binding Phosphoprotein Reference proteome | MTLNTEQEAK | MTLNTEQEAKTPLHRRASTPLPLSPRGHQPGRLSTVPSTQSQHPRLGQSASLNPPTQKPSPAPDDWSSESSDSEGSWEALYRVVLLGDPGVGKTSLASLFAGKQERDLHEQLGEDVYERTLTVDGEDTTLVVVDTWEAEKLDKSWSQESCLQGGSAYVIVYSIADRGSFESASELRIQLRRTHQADHVPIILVGNKADLARCREVSVEEGRACAVVFDCKFIETSATLQHNVAELFEGVVRQLRLRRRDSAAKEPPAPRRPASLAQRARRFLARLTARSARRRALKARSKSCHNLAVL | negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel regulation of skeletal muscle contraction by calcium ion signaling I band; plasma membrane; T-tubule calcium channel regulator activity calmodulin binding GTP binding GTPase activity transmembrane transporter binding Homo ... |
autophagy endocytosis lysosomal lumen acidification regulation of transcription by RNA polymerase II | azurophil granule lumen; endosome; extracellular exosome; extracellular region; extracellular space; transcription regulator complex | transcription corepressor activity | Homo sapiens | 3D-structure Direct protein sequencing Glycoprotein Growth regulation Reference proteome Secreted Signal | MAGLSRGSAR | MAGLSRGSARALLAALLASTLLALLVSPARGRGGRDHGDWDEASRLPPLPPREDAARVARFVTHVSDWGALATISTLEAVRGRPFADVLSLSDGPPGAGSGVPYFYLSPLQLSVSNLQENPYATLTMTLAQTNFCKKHGFDPQSPLCVHIMLSGTVTKVNETEMDIAKHSLFIRHPEMKTWPSSHNWFFAKLNITNIWVLDYFGGPKIVTPEEYYNVTVQ | autophagy endocytosis lysosomal lumen acidification regulation of transcription by RNA polymerase II azurophil granule lumen; endosome; extracellular exosome; extracellular region; extracellular space; transcription regulator complex transcription corepressor activity Homo sapiens 3D-structure Direct protein sequencing... |
cell surface pattern recognition receptor signaling pathway complement activation complement activation, lectin pathway defense response to virus negative regulation of RNA biosynthetic process negative regulation of viral entry into host cell positive regulation of opsonization proteolysis recognition of apoptotic cel... | blood microparticle; collagen trimer; collagen-containing extracellular matrix; external side of plasma membrane; extracellular region; extracellular space; serine-type endopeptidase complex | antigen binding carbohydrate binding carbohydrate derivative binding metal ion binding signaling receptor binding | Homo sapiens | 3D-structure Alternative splicing Calcium Collagen Complement activation lectin pathway Direct protein sequencing Disulfide bond Glycoprotein Hydroxylation Immunity Innate immunity Lectin Metal-binding Reference proteome Repeat Secreted Signal | MDLLWILPSL | MDLLWILPSLWLLLLGGPACLKTQEHPSCPGPRELEASKVVLLPSCPGAPGSPGEKGAPGPQGPPGPPGKMGPKGEPGDPVNLLRCQEGPRNCRELLSQGATLSGWYHLCLPEGRALPVFCDMDTEGGGWLVFQRRQDGSVDFFRSWSSYRAGFGNQESEFWLGNENLHQLTLQGNWELRVELEDFNGNRTFAHYATFRLLGEVDHYQLALGKFSEGTAGDSLSLHSGRPFTTYDADHDSSNSNCAVIVHGAWWYASCYRSNLNGRYAVSEAAAHKYGIDWASGRGVGHPYRRVRMMLR | cell surface pattern recognition receptor signaling pathway complement activation complement activation, lectin pathway defense response to virus negative regulation of RNA biosynthetic process negative regulation of viral entry into host cell positive regulation of opsonization proteolysis recognition of apoptotic cel... |
tRNA wobble position uridine thiolation | mitochondrion | ATP binding tRNA binding tRNA-5-taurinomethyluridine 2-sulfurtransferase | Homo sapiens | Alternative splicing ATP-binding Deafness Disease variant Disulfide bond Mitochondrion Non-syndromic deafness Nucleotide-binding Reference proteome RNA-binding Transferase tRNA processing tRNA-binding | MQALRHVVCA | MQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFSDFLNEYEKGRTPNPDIVCNKHIKFSCFFHYAVDNLGADAIATGHYARTSLEDEEVFEQKHVKKPEGLFRNRFEVRNAVKLLQAADSFKDQTFFLSQVSQDALRRTIFPLGGLTKEFVKKIAAENRLHHVLQKKESMGMCFIGKRNFEHFLLQYLQPRPGHFISIEDNKVLGTHKGWFLYTLGQRANIGGLREPWYVVEKDSVKGDVFVAPRTDHPALYRDLLRTSRVHWIAEEPPAA... | tRNA wobble position uridine thiolation mitochondrion ATP binding tRNA binding tRNA-5-taurinomethyluridine 2-sulfurtransferase Homo sapiens Alternative splicing ATP-binding Deafness Disease variant Disulfide bond Mitochondrion Non-syndromic deafness Nucleotide-binding Reference proteome RNA-binding Transferase tRNA pro... |
cilium assembly epithelial cilium movement involved in determination of left/right asymmetry | centriolar satellite; centriole; centrosome; ciliary basal body; cilium; cytosol; extracellular region; membrane; microtubule cytoskeleton; motile cilium; nucleus | alpha-tubulin binding gamma-tubulin binding identical protein binding molecular adaptor activity | Homo sapiens | Alternative splicing Cell projection Ciliopathy Cilium Cilium biogenesis/degradation Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Joubert syndrome Nucleus Phosphoprotein Reference proteome Retinitis pigmentosa Ubl conjugation | MMAQSNMFTV | MMAQSNMFTVADVLSQDELRKKLYQTFKDRGILDTLKTQLRNQLIHELMHPVLSGELQPRSISVEGSSLLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPTSSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLIDDQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEKELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGREAELKQRVEAFELNQKLQEEK... | cilium assembly epithelial cilium movement involved in determination of left/right asymmetry centriolar satellite; centriole; centrosome; ciliary basal body; cilium; cytosol; extracellular region; membrane; microtubule cytoskeleton; motile cilium; nucleus alpha-tubulin binding gamma-tubulin binding identical protein bi... |
activation of protein kinase activity negative regulation of mitotic nuclear division positive regulation of protein autophosphorylation protein transport signal transduction ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | cytoplasm; cytosol; endosome; endosome membrane; extracellular exosome; Golgi stack; lysosome; membrane | clathrin binding phosphatidylinositol binding protein kinase activator activity protein kinase binding SH3 domain binding ubiquitin binding | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Endosome Golgi apparatus Membrane Phosphoprotein Protein transport Reference proteome SH3-binding Transport | MAFGKSHRDP | MAFGKSHRDPYATSVGHLIEKATFAGVQTEDWGQFMHICDIINTTQDGPKDAVKALKKRISKNYNHKEIQLTLSLIDMCVQNCGPSFQSLIVKKEFVKENLVKLLNPRYNLPLDIQNRILNFIKTWSQGFPGGVDVSEVKEVYLDLVKKGVQFPPSEAEAETARQETAQISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGKLHSELDMVKMNVRVMSAILMENTPGSENHEDIELLQKLYKTGREMQERIMDLLVVVENEDVTVELIQVNEDLNNAILGYERFTRNQQRILEQNKNQKEATNTTSEPSAPSQDLLDL... | activation of protein kinase activity negative regulation of mitotic nuclear division positive regulation of protein autophosphorylation protein transport signal transduction ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway cytoplasm; cytosol; endosome; endosome membrane; extrac... |
inflammatory response interleukin-1-mediated signaling pathway intracellular signal transduction negative regulation of cytokine production positive regulation of CREB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of transcription by RNA polymerase II p... | cytoplasm; cytosol; nucleoplasm; nucleus; synapse | ATP binding histone H3S10 kinase activity histone H3S28 kinase activity magnesium ion binding protein serine kinase activity protein serine/threonine kinase activity ribosomal protein S6 kinase activity | Homo sapiens | Alternative splicing ATP-binding Inflammatory response Kinase Magnesium Metal-binding Nucleotide-binding Nucleus Phosphoprotein Reference proteome Repeat Serine/threonine-protein kinase Stress response Transferase | MGDEDDDESC | MGDEDDDESCAVELRITEANLTGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAALVQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQYFKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKERTFSFCGTIEYMAPEIIRSKTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVSRRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAARKIPAPFRP... | inflammatory response interleukin-1-mediated signaling pathway intracellular signal transduction negative regulation of cytokine production positive regulation of CREB transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of transcription by RNA polymerase II p... |
cell cycle innate immune response negative regulation of cell division negative regulation of cell population proliferation negative regulation of G2/M transition of mitotic cell cycle negative regulation of mitotic cell cycle positive regulation of apoptotic process positive regulation of autophagy positive regulation... | cytoplasm; cytosol; nucleoplasm | metal ion binding protein homodimerization activity protein kinase binding ubiquitin protein ligase activity | Homo sapiens | Cell cycle Cytoplasm Metal-binding Nucleus Phosphoprotein Reference proteome Zinc Zinc-finger | MKRLSLVTTN | MKRLSLVTTNRLSPHGNFLPLCTFPLAVDMAALFQEASSCPVCSDYLEKPMSLECGCAVCFKCINSLQKEPHGEDLLCCCCSMVSQKNKIRPSWQLERLASHIKELEPKLKKILQMNPRMRKFQVDMTLDADTANNFLLISDDLRSVRSGCITQNRQDLAERFDVSICILGSPRFTCGRHYWEVDVGTSTEWDLGVCRESVHRKGRIHLTTERGFWTVSLRDGSRLSASTVPLTFLFVDRKLQRVGIFLDMGMQNVSFFDAEGGSHVYTFRSVSAEEPLHLFFAPPSPPNGDKSVLSICPVINPGTTDAPVHPGEAK | cell cycle innate immune response negative regulation of cell division negative regulation of cell population proliferation negative regulation of G2/M transition of mitotic cell cycle negative regulation of mitotic cell cycle positive regulation of apoptotic process positive regulation of autophagy positive regulation... |
innate immune response positive regulation of autophagy positive regulation of canonical NF-kappaB signal transduction protein polyubiquitination regulation of protein localization regulation of viral entry into host cell | cytoplasm; cytosol; nucleoplasm | metal ion binding protein homodimerization activity protein kinase binding ubiquitin protein ligase activity | Homo sapiens | Alternative splicing Metal-binding Reference proteome Zinc Zinc-finger | MEVAELGFPE | MEVAELGFPETAVSQSRICLCAVLCGHWDFADMMVIRSLSLIRLEGVEGRDPVGGGNLTNKRPSCAPSPQDLSAQWKQLEDRGASSRRVDMAALFQEASSCPVCSDYLEKPMSLECGCAVCLKCINSLQKEPHGEDLLCCCSSMVSRKNKIRRNRQLERLASHIKELEPKLKKILQMNPRMRKFQVDMTLDANTANNFLLISDDLRSVRSGRIRQNRQDLAERFDVSVCILGSPRFTCGRHCWEVDVGTSTEWDLGVCRESVHRKGRIQLTTELGFWTVSLRDGGRLSATTVPLTFLFVDRKLQRVGIFLDMGMQNVSFF... | innate immune response positive regulation of autophagy positive regulation of canonical NF-kappaB signal transduction protein polyubiquitination regulation of protein localization regulation of viral entry into host cell cytoplasm; cytosol; nucleoplasm metal ion binding protein homodimerization activity protein kinase... |
innate immune response positive regulation of autophagy positive regulation of canonical NF-kappaB signal transduction protein polyubiquitination regulation of protein localization regulation of viral entry into host cell | cytoplasm; cytosol; nucleoplasm | metal ion binding protein homodimerization activity protein kinase binding ubiquitin protein ligase activity | Homo sapiens | Alternative splicing Cytoplasm Host-virus interaction Metal-binding Nucleus Reference proteome Zinc Zinc-finger | MKRLSLVTTN | MKRLSLVTTNRLSPQGNFLPLCTFPLAVDMAALFQEASSCPVCSDYLEKPMSLECGCTVCLKCINSLQKEPHGEDLLCCCCSMVSQRNKIRPNRQLERLVSHIKELEPKLKKILQMNPRMRKFQVDMTLDADTANNFLLISDDLRSVRSGLITQNRQDLAERFDVSVCILGSPRFTCGRHYWEVDVGTSTEWDLGVCRESVHCKGKIQLTTELGFWTVSLRDGSRLSASTVPLTFLLVDRKLQRVGIFLDMGMQNVSFFDAESGSHVYTFRSVSAEEPLRPFLAPSIPPNGDQGVLSICPLMNSGTTDAPVRPGEAK | innate immune response positive regulation of autophagy positive regulation of canonical NF-kappaB signal transduction protein polyubiquitination regulation of protein localization regulation of viral entry into host cell cytoplasm; cytosol; nucleoplasm metal ion binding protein homodimerization activity protein kinase... |
N-terminal protein myristoylation negative regulation of canonical NF-kappaB signal transduction negative regulation of defense response to virus negative regulation of interferon-beta production negative regulation of non-canonical NF-kappaB signal transduction peptidyl-threonine dephosphorylation positive regulation ... | cytosol; membrane; nucleolus; nucleus | magnesium ion binding manganese ion binding myosin phosphatase activity protein serine/threonine phosphatase activity | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Hydrolase Isopeptide bond Lipoprotein Magnesium Manganese Membrane Metal-binding Myristate Phosphoprotein Protein phosphatase Reference proteome Ubl conjugation | MGAFLDKPKT | MGAFLDKPKTEKHNAHGAGNGLRYGLSSMQGWRVEMEDAHTAVVGIPHGLEDWSFFAVYDGHAGSRVANYCSTHLLEHITTNEDFRAAGKSGSALELSVENVKNGIRTGFLKIDEYMRNFSDLRNGMDRSGSTAVGVMISPKHIYFINCGDSRAVLYRNGQVCFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVYEILRAEEDEFIILACDGIWDVMSNEELCEYVKSRLEVSDDLENVCNWVVDTCLHKGSRDNMSIVLVCFSNAPKVSDEAVKKDSELDKHLESRV... | N-terminal protein myristoylation negative regulation of canonical NF-kappaB signal transduction negative regulation of defense response to virus negative regulation of interferon-beta production negative regulation of non-canonical NF-kappaB signal transduction peptidyl-threonine dephosphorylation positive regulation ... |
cell surface receptor signaling pathway regulation of GTPase activity | cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleus; plasma membrane | GTPase activator activity inositol 1,3,4,5 tetrakisphosphate binding metal ion binding phosphatidylinositol bisphosphate binding phosphatidylinositol-3,4,5-trisphosphate binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm GTPase activation Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Zinc Zinc-finger | MAKERRRAVL | MAKERRRAVLELLQRPGNARCADCGAPDPDWASYTLGVFICLSCSGIHRNIPQVSKVKSVRLDAWEEAQVEFMASHGNDAARARFESKVPSFYYRPTPSDCQLLREQWIRAKYERQEFIYPEKQEPYSAGYREGFLWKRGRDNGQFLSRKFVLTEREGALKYFNRNDAKEPKAVMKIEHLNATFQPAKIGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGAGDADLVPKLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLHGFPPSTQGHH... | cell surface receptor signaling pathway regulation of GTPase activity cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleus; plasma membrane GTPase activator activity inositol 1,3,4,5 tetrakisphosphate binding metal ion binding phosphatidylinositol bisphosphate binding phosphatidylinositol-3,4,5-trispho... |
cilium assembly post-Golgi vesicle-mediated transport protein folding protein transport visual perception | centriole; ciliary basal body; cilium; cytoplasm; cytoplasmic vesicle; extracellular exosome; Golgi apparatus; nuclear body; nucleoplasm; periciliary membrane compartment; plasma membrane | GTP binding GTPase activator activity magnesium ion binding unfolded protein binding | Homo sapiens | 3D-structure Cell membrane Cell projection Cilium Disease variant GTP-binding GTPase activation Lipoprotein Membrane Myristate Nucleotide-binding Palmitate Protein transport Reference proteome Retinitis pigmentosa Transport | MGCFFSKRRK | MGCFFSKRRKADKESRPENEEERPKQYSWDQREKVDPKDYMFSGLKDETVGRLPGTVAGQQFLIQDCENCNIYIFDHSATVTIDDCTNCIIFLGPVKGSVFFRNCRDCKCTLACQQFRVRDCRKLEVFLCCATQPIIESSSNIKFGCFQWYYPELAFQFKDAGLSIFNNTWSNIHDFTPVSGELNWSLLPEDAVVQDYVPIPTTEELKAVRVSTEANRSIVPISRGQRQKSSDESCLVVLFAGDYTIANARKLIDEMVGKGFFLVQTKEVSMKAEDAQRVFREKAPDFLPLLNKGPVIALEFNGDGAVEVCQLIVNEIFN... | cilium assembly post-Golgi vesicle-mediated transport protein folding protein transport visual perception centriole; ciliary basal body; cilium; cytoplasm; cytoplasmic vesicle; extracellular exosome; Golgi apparatus; nuclear body; nucleoplasm; periciliary membrane compartment; plasma membrane GTP binding GTPase activat... |
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