Biological Process stringlengths 7 1.01k | Cellular Component stringlengths 6 867 | Molecular Function stringlengths 11 871 | Organism stringlengths 8 73 | Keywords stringlengths 1 810 | Sequence 10 stringlengths 5 10 | Sequence stringlengths 5 1.02k | Combined stringlengths 136 3.91k |
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bicellular tight junction assembly calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell adhesion protein-containing complex assembly | bicellular tight junction; endoplasmic reticulum; plasma membrane | identical protein binding structural molecule activity | Homo sapiens | Cell junction Cell membrane Deafness Disease variant Membrane Non-syndromic deafness Reference proteome Tight junction Transmembrane Transmembrane helix | MASTAVQLLG | MASTAVQLLGFLLSFLGMVGTLITTILPHWRRTAHVGTNILTAVSYLKGLWMECVWHSTGIYQCQIYRSLLALPQDLQAARALMVISCLLSGIACACAVIGMKCTRCAKGTPAKTTFAILGGTLFILAGLLCMVAVSWTTNDVVQNFYNPLLPSGMKFEIGQALYLGFISSSLSLIGGTLLCLSCQDEAPYRPYQAPPRATTTTANTAPAYQPPAAYKDNRAPSVTSATHSGYRLNDYV | bicellular tight junction assembly calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell adhesion protein-containing complex assembly bicellular tight junction; endoplasmic reticulum; plasma membrane identical protein binding structural molecule activity Homo sapiens Cell junction Cell... |
chromatin organization negative regulation of transcription by RNA polymerase II | chromatin; heterochromatin; nuclear body; nucleoplasm; nucleus; PcG protein complex; PRC1 complex | chromatin binding methylated histone binding single-stranded RNA binding | Homo sapiens | 3D-structure Chromatin regulator Chromosome Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation Ubl conjugation | MELSAVGERV | MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKVIDKGAGGGGAGQGAGALARPKVPSRNRVIGKSKKFSESVLRTQIRHMKFGAFALYKPPPAPLVAPSPGKAEASAPGPGLLLAAPAAPYDARSSGSSGCPSPTPQSSDPDDTPPKLLPETVSPSAPSWREPEVLDLSLPPE... | chromatin organization negative regulation of transcription by RNA polymerase II chromatin; heterochromatin; nuclear body; nucleoplasm; nucleus; PcG protein complex; PRC1 complex chromatin binding methylated histone binding single-stranded RNA binding Homo sapiens 3D-structure Chromatin regulator Chromosome Nucleus Pho... |
artery development cell redox homeostasis circulatory system development dehydroascorbic acid transport embryonic skeletal joint development galactose transmembrane transport glucose import across plasma membrane glucose transmembrane transport hexose transmembrane transport negative regulation of connective tissue gro... | cytosol; endomembrane system; membrane; perinuclear region of cytoplasm; plasma membrane | carbohydrate:proton symporter activity D-glucose transmembrane transporter activity dehydroascorbic acid transmembrane transporter activity symporter activity | Homo sapiens | Cytoplasm Disease variant Glycoprotein Membrane Reference proteome Sugar transport Transmembrane Transmembrane helix Transport | MGHSPPVLPL | MGHSPPVLPLCASVSLLGGLTFGYELAVISGALLPLQLDFGLSCLEQEFLVGSLLLGALLASLVGGFLIDCYGRKQAILGSNLVLLAGSLTLGLAGSLAWLVLGRAVVGFAISLSSMACCIYVSELVGPRQRGVLVSLYEAGITVGILLSYALNYALAGTPWGWRHMFGWATAPAVLQSLSLLFLPAGTDETATHKDLIPLQGGEAPKLGPGRPRYSFLDLFRARDNMRGRTTVGLGLVLFQQLTGQPNVLCYASTIFSSVGFHGGSSAVLASVGLGAVKVAATLTAMGLVDRAGRRALLLAGCALMALSVSGIGLVSFA... | artery development cell redox homeostasis circulatory system development dehydroascorbic acid transport embryonic skeletal joint development galactose transmembrane transport glucose import across plasma membrane glucose transmembrane transport hexose transmembrane transport negative regulation of connective tissue gro... |
ATP metabolic process NAD metabolic process NADP biosynthetic process phosphorylation positive regulation of insulin secretion involved in cellular response to glucose stimulus | cytosol | ATP binding metal ion binding NAD+ kinase activity | Homo sapiens | 3D-structure Alternative splicing ATP-binding Kinase Metal-binding NAD NADP Nucleotide-binding Phosphoprotein Reference proteome Transferase | MEMEQEKMTM | MEMEQEKMTMNKELSPDAAAYCCSACHGDETWSYNHPIRGRAKSRSLSASPALGSTKEFRRTRSLHGPCPVTTFGPKACVLQNPQTIMHIQDPASQRLTWNKSPKSVLVIKKMRDASLLQPFKELCTHLMEENMIVYVEKKVLEDPAIASDESFGAVKKKFCTFREDYDDISNQIDFIICLGGDGTLLYASSLFQGSVPPVMAFHLGSLGFLTPFSFENFQSQVTQVIEGNAAVVLRSRLKVRVVKELRGKKTAVHNGLGENGSQAAGLDMDVGKQAMQYQVLNEVVIDRGPSSYLSNVDVYLDGHLITTVQGDGVIVST... | ATP metabolic process NAD metabolic process NADP biosynthetic process phosphorylation positive regulation of insulin secretion involved in cellular response to glucose stimulus cytosol ATP binding metal ion binding NAD+ kinase activity Homo sapiens 3D-structure Alternative splicing ATP-binding Kinase Metal-binding NAD ... |
cell surface receptor signaling pathway double-strand break repair neuron development | aggresome; cytoplasm; nuclear body; nucleolus; nucleoplasm; nucleus; PML body | 5'-tyrosyl-DNA phosphodiesterase activity magnesium ion binding manganese ion binding nuclease activity single-stranded DNA binding transcription corepressor activity tyrosyl-RNA phosphodiesterase activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm DNA damage DNA repair Host-virus interaction Hydrolase Intellectual disability Isopeptide bond Magnesium Metal-binding Neurodegeneration Nuclease Nucleus Phosphoprotein Reference proteome Spinocerebellar ataxia Ubl conjugation | MELGSCLEGG | MELGSCLEGGREAAEEEGEPEVKKRRLLCVEFASVASCDAAVAQCFLAENDWEMERALNSYFEPPVEESALERRPETISEPKTYVDLTNEETTDSTTSKISPSEDTQQENGSMFSLITWNIDGLDLNNLSERARGVCSYLALYSPDVIFLQEVIPPYYSYLKKRSSNYEIITGHEEGYFTAIMLKKSRVKLKSQEIIPFPSTKMMRNLLCVHVNVSGNELCLMTSHLESTRGHAAERMNQLKMVLKKMQEAPESATVIFAGDTNLRDREVTRCGGLPNNIVDVWEFLGKPKHCQYTWDTQMNSNLGITAACKLRFDRIFF... | cell surface receptor signaling pathway double-strand break repair neuron development aggresome; cytoplasm; nuclear body; nucleolus; nucleoplasm; nucleus; PML body 5'-tyrosyl-DNA phosphodiesterase activity magnesium ion binding manganese ion binding nuclease activity single-stranded DNA binding transcription corepresso... |
acetyl-CoA biosynthetic process from pyruvate mitochondrial pyruvate transmembrane transport positive regulation of insulin secretion involved in cellular response to glucose stimulus | inner mitochondrial membrane protein complex; mitochondrial inner membrane; mitochondrion; nucleus | identical protein binding pyruvate transmembrane transporter activity | Homo sapiens | Membrane Mitochondrion Mitochondrion inner membrane Reference proteome Transmembrane Transmembrane helix Transport | MSAAGARGLR | MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK | acetyl-CoA biosynthetic process from pyruvate mitochondrial pyruvate transmembrane transport positive regulation of insulin secretion involved in cellular response to glucose stimulus inner mitochondrial membrane protein complex; mitochondrial inner membrane; mitochondrion; nucleus identical protein binding pyruvate tr... |
peptidyl-lysine monomethylation regulation of ribosome biogenesis regulation of rRNA processing regulation of translation regulation of translational elongation | cytosol; nucleolus; nucleus; protein-containing complex | heat shock protein binding protein-L-histidine N-tele-methyltransferase activity | Homo sapiens | 3D-structure Cytoplasm Methylation Methyltransferase Nucleus Phosphoprotein Reference proteome S-adenosyl-L-methionine Transferase | MTFQFNFTIE | MTFQFNFTIEDHLENELTPIRDGALTLDSSKELSVSESQKGEERDRKCSAEQFDLPQDHLWEHKSMENAAPSQDTDSPLSAASSSRNLEPHGKQPSLRAAKEHAMPKDLKKMLENKVIETLPGFQHVKLSVVKTILLKENFPGENIVSKSFSSHSDLITGVYEGGLKIWECTFDLLAYFTKAKVKFAGKKVLDLGCGSGLLGITAFKGGSKEIHFQDYNSMVIDEVTLPNVVANSTLEDEENDVNEPDVKRCRKPKVTQLYKCRFFSGEWSEFCKLVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVL... | peptidyl-lysine monomethylation regulation of ribosome biogenesis regulation of rRNA processing regulation of translation regulation of translational elongation cytosol; nucleolus; nucleus; protein-containing complex heat shock protein binding protein-L-histidine N-tele-methyltransferase activity Homo sapiens 3D-struct... |
glutathione metabolic process hydrogen sulfide metabolic process | cytoplasm; mitochondrial matrix; mitochondrion; nucleoplasm | identical protein binding iron ion binding sulfur dioxygenase activity | Homo sapiens | 3D-structure Acetylation Cytoplasm Dioxygenase Disease variant Iron Metal-binding Mitochondrion Nucleus Oxidoreductase Phosphoprotein Reference proteome Transit peptide | MAEAVLRVAR | MAEAVLRVARRQLSQRGGSGAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKELGLRLLYAVNTHCHADHITGSGLLRSLLPGCQSVISRLSGAQADLHIEDGDSIRFGRFALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQQGCAKTLYHSVHEKIFTLPGDCLIYPAHDYHGFTVSTVEEERTLNPRLTLSCEEFVKIMGNLNLPKPQQIDFAVPANMRCGVQTPTA | glutathione metabolic process hydrogen sulfide metabolic process cytoplasm; mitochondrial matrix; mitochondrion; nucleoplasm identical protein binding iron ion binding sulfur dioxygenase activity Homo sapiens 3D-structure Acetylation Cytoplasm Dioxygenase Disease variant Iron Metal-binding Mitochondrion Nucleus Oxidore... |
fatty acid metabolic process long-chain fatty acid import into cell long-chain fatty acid metabolic process long-chain fatty-acyl-CoA biosynthetic process long-chain fatty-acyl-CoA metabolic process neuron differentiation positive regulation of Golgi to plasma membrane protein transport positive regulation of phosphati... | endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; lipid droplet; membrane; mitochondrial outer membrane; perinuclear region of cytoplasm; peroxisomal membrane; plasma membrane | arachidonate-CoA ligase activity ATP binding long-chain fatty acid-CoA ligase activity medium-chain fatty acid-CoA ligase activity palmitoyl-CoA ligase activity protein domain specific binding protein kinase binding | Homo sapiens | ATP-binding Endoplasmic reticulum Fatty acid metabolism Ligase Lipid metabolism Magnesium Membrane Microsome Mitochondrion Mitochondrion outer membrane Nucleotide-binding Peroxisome Phosphoprotein Reference proteome Signal-anchor Transmembrane Transmembrane helix | MNNHVSSKPS | MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGE... | fatty acid metabolic process long-chain fatty acid import into cell long-chain fatty acid metabolic process long-chain fatty-acyl-CoA biosynthetic process long-chain fatty-acyl-CoA metabolic process neuron differentiation positive regulation of Golgi to plasma membrane protein transport positive regulation of phosphati... |
negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | aggresome; chromatin; cytosol; nucleoplasm | DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | Alternative splicing DNA-binding Isopeptide bond Metal-binding Nucleus Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MVDMDKLINN | MVDMDKLINNLEVQLNSEGGSMQVFKQVTASVRNRDPPEIEYRSNMTSPTLLDANPMENPALFNDIKIEPPEELLASDFSLPQVEPVDLSFHKPKAPLQPASMLQAPIRPPKPQSSPQTLVVSTSTSDMSTSANIPTVLTPGSVLTSSQSTGSQQILHVIHTIPSVSLPNKMGGLKTIPVVVQSLPMVYTTLPADGGPAAITVPLIGGDGKNAGSVKVDPTSMSPLEIPSDSEESTIESGSSALQSLQGLQQEPAAMAQMQGEESLDLKRRRIHQCDFAGCSKVYTKSSHLKAHRRIHTGEKPYKCTWDGCSWKFARSDE... | negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II aggresome; chromatin; cytosol; nucleoplasm DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific metal ion binding RNA polym... |
chromatin remodeling mitotic cell cycle positive regulation of DNA-templated transcription positive regulation of double-strand break repair via homologous recombination regulation of apoptotic process regulation of cell cycle regulation of DNA-templated transcription regulation of double-strand break repair regulation... | NuA4 histone acetyltransferase complex; nuclear matrix; nuclear membrane; nucleoplasm; nucleosome; nucleus | histone binding lysine-acetylated histone binding modification-dependent protein binding structural constituent of cytoskeleton | Homo sapiens | 3D-structure Chromatin regulator Coiled coil Direct protein sequencing Growth regulation Isopeptide bond Nucleus Reference proteome Transcription Transcription regulation Ubl conjugation | MFKRMAEFGP | MFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKLEEDDQAKDI | chromatin remodeling mitotic cell cycle positive regulation of DNA-templated transcription positive regulation of double-strand break repair via homologous recombination regulation of apoptotic process regulation of cell cycle regulation of DNA-templated transcription regulation of double-strand break repair regulation... |
nuclear-transcribed mRNA poly(A) tail shortening protein autoubiquitination protein ubiquitination regulation of megakaryocyte differentiation ubiquitin-dependent protein catabolic process | CCR4-NOT complex; cytosol; nucleus | metal ion binding RNA binding ubiquitin-protein transferase activity | Homo sapiens | 3D-structure Alternative splicing Coiled coil Cytoplasm Metal-binding Methylation Nucleus Phosphoprotein Reference proteome RNA-binding Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger | MSRSPDAKED | MSRSPDAKEDPVECPLCMEPLEIDDINFFPCTCGYQICRFCWHRIRTDENGLCPACRKPYPEDPAVYKPLSQEELQRIKNEKKQKQNERKQKISENRKHLASVRVVQKNLVFVVGLSQRLADPEVLKRPEYFGKFGKIHKVVINNSTSYAGSQGPSASAYVTYIRSEDALRAIQCVNNVVVDGRTLKASLGTTKYCSYFLKNMQCPKPDCMYLHELGDEAASFTKEEMQAGKHQEYEQKLLQELYKLNPNFLQLSTGSVDKNKNKVTPLQRYDTPIDKPSDSLSIGNGDNSQQISNSDTPSPPPGLSKSNPVIPISSSNH... | nuclear-transcribed mRNA poly(A) tail shortening protein autoubiquitination protein ubiquitination regulation of megakaryocyte differentiation ubiquitin-dependent protein catabolic process CCR4-NOT complex; cytosol; nucleus metal ion binding RNA binding ubiquitin-protein transferase activity Homo sapiens 3D-structure A... |
hippocampal neuron apoptotic process mitotic cytokinesis negative regulation of hippocampal neuron apoptotic process negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of Ras protein signal transduction positive regulation of cell population proliferation prote... | cleavage furrow; cytosol; early endosome; endosome; extracellular exosome; nucleoplasm; nucleus; plasma membrane | deubiquitinase activity K63-linked deubiquitinase activity metal ion binding metal-dependent deubiquitinase activity protein domain specific binding | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Disease variant Endosome Hydrolase Membrane Metal-binding Metalloprotease Nucleus Phosphoprotein Protease Reference proteome Ubl conjugation Ubl conjugation pathway Zinc | MSDHGDVSLP | MSDHGDVSLPPEDRVRALSQLGSAVEVNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAVIPEKKDTVKKLKEIAFPKAEELKAELLKRYTKEYTEYNEEKKKEAEELARNMAIQQELEKEKQRVAQQKQQQLEQEQFHAFEEMIRNQELEKERLKIVQEFGKVDPGLGGPLVPDLEKPSLDVFPTLTVSSIQPSDCHTTVRPAKPPVVDRSLKPGALSNSESIPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVLIPKQSAGSDYCNTENEEELF... | hippocampal neuron apoptotic process mitotic cytokinesis negative regulation of hippocampal neuron apoptotic process negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of Ras protein signal transduction positive regulation of cell population proliferation prote... |
anterior/posterior axon guidance apoptotic process Cdc42 protein signal transduction cell-cell adhesion chemorepulsion of axon glial cell proliferation inner ear morphogenesis mammary gland duct morphogenesis motor neuron migration negative regulation of axon extension nuclear migration positive regulation of axon exte... | actin cytoskeleton; basement membrane; cytosol; extracellular region; nucleoplasm | DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | 3D-structure Apoptosis Cytoplasm Disease variant Disulfide bond Glycoprotein Laminin EGF-like domain Reference proteome Repeat Secreted Signal | MMRAVWEALA | MMRAVWEALAALAAVACLVGAVRGGPGLSMFAGQAAQPDPCSDENGHPRRCIPDFVNAAFGKDVRVSSTCGRPPARYCVVSERGEERLRSCHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSENYLQFPHNVTLTLSLGKKFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRAPITKQNEQEAVCTDSHTDMRPLSGGLIAFSTLDGRPSAHDFDNSPVLQDWVTATDIRVAFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKP... | anterior/posterior axon guidance apoptotic process Cdc42 protein signal transduction cell-cell adhesion chemorepulsion of axon glial cell proliferation inner ear morphogenesis mammary gland duct morphogenesis motor neuron migration negative regulation of axon extension nuclear migration positive regulation of axon exte... |
cell differentiation hematopoietic progenitor cell differentiation negative regulation of activin receptor signaling pathway negative regulation of BMP signaling pathway negative regulation of osteoclast differentiation negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway ossi... | endoplasmic reticulum lumen; extracellular region; extracellular space; nucleoplasm; nucleus | activin binding fibronectin binding | Homo sapiens | 3D-structure Alternative initiation Chromosomal rearrangement Direct protein sequencing Disulfide bond Glycoprotein Nucleus Osteogenesis Phosphoprotein Proto-oncogene Reference proteome Repeat Secreted Signal Transcription Transcription regulation | MRPGAPGPLW | MRPGAPGPLWPLPWGALAWAVGFVSSMGSGNPAPGGVCWLQQGQEATCSLVLQTDVTRAECCASGNIDTAWSNLTHPGNKINLLGFLGLVHCLPCKDSCDGVECGPGKACRMLGGRPRCECAPDCSGLPARLQVCGSDGATYRDECELRAARCRGHPDLSVMYRGRCRKSCEHVVCPRPQSCVVDQTGSAHCVVCRAAPCPVPSSPGQELCGNNNVTYISSCHMRQATCFLGRSIGVRHAGSCAGTPEEPPGGESAEEEENFV | cell differentiation hematopoietic progenitor cell differentiation negative regulation of activin receptor signaling pathway negative regulation of BMP signaling pathway negative regulation of osteoclast differentiation negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway ossi... |
mRNA processing | intracellular membrane-bounded organelle; mRNA cleavage and polyadenylation specificity factor complex; nucleoplasm | RNA binding sequence-specific double-stranded DNA binding zinc ion binding | Homo sapiens | 3D-structure Alternative splicing Host-virus interaction Metal-binding mRNA processing Nucleus Phosphoprotein Reference proteome Repeat RNA-binding Zinc Zinc-finger | MQEIIASVDH | MQEIIASVDHIKFDLEIAVEQQLGAQPLPFPGMDKSGAAVCEFFLKAACGKGGMCPFRHISGEKTVVCKHWLRGLCKKGDQCEFLHEYDMTKMPECYFYSKFGECSNKECPFLHIDPESKIKDCPWYDRGFCKHGPLCRHRHTRRVICVNYLVGFCPEGPSCKFMHPRFELPMGTTEQPPLPQQTQPPAKQSNNPPLQRSSSLIQLTSQNSSPNQQRTPQVIGVMQSQNSSAGNRGPRPLEQVTCYKCGEKGHYANRCTKGHLAFLSGQ | mRNA processing intracellular membrane-bounded organelle; mRNA cleavage and polyadenylation specificity factor complex; nucleoplasm RNA binding sequence-specific double-stranded DNA binding zinc ion binding Homo sapiens 3D-structure Alternative splicing Host-virus interaction Metal-binding mRNA processing Nucleus Phosp... |
aortic valve morphogenesis calcineurin-NFAT signaling cascade cellular response to transforming growth factor beta stimulus cellular response to tumor necrosis factor intracellular signal transduction mononuclear cell differentiation negative regulation of vascular associated smooth muscle cell differentiation negative... | chromatin; cytoplasm; cytosol; nuclear body; nucleoplasm; nucleus; perinuclear region of cytoplasm; sarcoplasm; transcription regulator complex | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific FK506 binding mitogen-activated protein kinase p38 binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specif... | Homo sapiens | 3D-structure Activator Alternative initiation Alternative splicing Cytoplasm DNA-binding Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation | MPSTSFPVPS | MPSTSFPVPSKFPLGPAAAVFGRGETLGPAPRAGGTMKSAEEEHYGYASSNVSPALPLPTAHSTLPAPCHNLQTSTPGIIPPADHPSGYGAALDGGPAGYFLSSGHTRPDGAPALESPRIEITSCLGLYHNNNQFFHDVEVEDVLPSSKRSPSTATLSLPSLEAYRDPSCLSPASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRGLGACTLLGSPRHSPSTSPRASVTEESWLGARSSRPASPCNKRKYSLNGRQPPYSPHHSPTPSPHGSPRVSVTDDSWLGNTTQYTSSAIVAAINALT... | aortic valve morphogenesis calcineurin-NFAT signaling cascade cellular response to transforming growth factor beta stimulus cellular response to tumor necrosis factor intracellular signal transduction mononuclear cell differentiation negative regulation of vascular associated smooth muscle cell differentiation negative... |
regulation of macroautophagy synaptic vesicle lumen acidification | clathrin-coated vesicle membrane; cytosol; melanosome; synaptic vesicle membrane; vacuolar proton-transporting V-type ATPase complex; vacuolar proton-transporting V-type ATPase, V1 domain | ATP hydrolysis activity proton-transporting ATPase activity, rotational mechanism | Homo sapiens | Alternative splicing Cytoplasmic vesicle Hydrogen ion transport Ion transport Membrane Reference proteome Transport | MASQSQGIQQ | MASQSQGIQQLLQAEKRAAEKVADARKRKARRLKQAKEEAQMEVEQYRREREHEFQSKQQAAMGSQGNLSAEVEQATRRQVQGMQSSQQRNRERVLAQLLGMVCDVRPQVHPNYRISA | regulation of macroautophagy synaptic vesicle lumen acidification clathrin-coated vesicle membrane; cytosol; melanosome; synaptic vesicle membrane; vacuolar proton-transporting V-type ATPase complex; vacuolar proton-transporting V-type ATPase, V1 domain ATP hydrolysis activity proton-transporting ATPase activity, rotat... |
methylation nucleotide metabolic process | cytosol | dTTP diphosphatase activity nucleoside triphosphate diphosphatase activity O-methyltransferase activity UTP diphosphatase activity | Homo sapiens | 3D-structure Alternative splicing Hydrolase Methyltransferase Nucleotide metabolism Phosphoprotein Reference proteome S-adenosyl-L-methionine Transferase | MVLCPVIGKL | MVLCPVIGKLLHKRVVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASFATPYGYAMETAKQKALEVANRLYQKDLRAPDVVIGADTIVTVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQLDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKLYYPPRPEDLRRSVKHDSIPAADTFEDLSDVEGGGSEPTQRDAGSRDEKAEAGEAGQATAEAECHRTRETLPPFPTRLLELIEGFMLSKGLLTACKLKVFDLLKDEAPQK... | methylation nucleotide metabolic process cytosol dTTP diphosphatase activity nucleoside triphosphate diphosphatase activity O-methyltransferase activity UTP diphosphatase activity Homo sapiens 3D-structure Alternative splicing Hydrolase Methyltransferase Nucleotide metabolism Phosphoprotein Reference proteome S-adenosy... |
neuropeptide signaling pathway protein processing respiratory system process | plasma membrane | metal ion binding metalloendopeptidase activity metallopeptidase activity | Homo sapiens | Alternative splicing Disease variant Disulfide bond Glycoprotein Hydrolase Membrane Metal-binding Metalloprotease Protease Reference proteome Signal-anchor Transmembrane Transmembrane helix Zinc | MEPPYSLTAH | MEPPYSLTAHYDEFQEVKYVSRCGAGGARGASLPPGFPLGAARSATGARSGLPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGPVAAGGGACPEGCPERKAFARAARFLAANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTYGTIAAIGEQNEERLRRLLARPGGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIEDCGGWDLGGAEERPGVAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEDSEKILAAYRVFMERVLSLLGADAVEQKAQEILQVEQQL... | neuropeptide signaling pathway protein processing respiratory system process plasma membrane metal ion binding metalloendopeptidase activity metallopeptidase activity Homo sapiens Alternative splicing Disease variant Disulfide bond Glycoprotein Hydrolase Membrane Metal-binding Metalloprotease Protease Reference proteom... |
CDP-diacylglycerol biosynthetic process lipid droplet formation phosphatidylglycerol biosynthetic process | endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial inner membrane | phosphatidate cytidylyltransferase activity | Homo sapiens | Alternative splicing Endoplasmic reticulum Lipid biosynthesis Lipid metabolism Membrane Nucleotidyltransferase Phospholipid biosynthesis Phospholipid metabolism Phosphoprotein Reference proteome Transferase Transmembrane Transmembrane helix | MTELRQRVAH | MTELRQRVAHEPVAPPEDKESESEAKVDGETASDSESRAESAPLPVSADDTPEVLNRALSNLSSRWKNWWVRGILTLAMIAFFFIIIYLGPMVLMIIVMCVQIKCFHEIITIGYNVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFTLYLIGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNLFEGMIWFIVPISCVICNDIMAYMFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGLLLSYVMSGYRCFVCPVEYNNDTNSFTVDCEPSDLFRLQEYNIPGV... | CDP-diacylglycerol biosynthetic process lipid droplet formation phosphatidylglycerol biosynthetic process endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial inner membrane phosphatidate cytidylyltransferase activity Homo sapiens Alternative splicing Endoplasmic reticulum Lipid biosynthesis L... |
anatomical structure development anatomical structure morphogenesis cell differentiation chromatin organization DNA repair inner ear development negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of DNA repair visual perception | cytoplasm; nucleus | metal ion binding protein tyrosine phosphatase activity | Homo sapiens | Acetylation Activator Alternative splicing Cardiomyopathy Chromatin regulator Cytoplasm Deafness Developmental protein Disease variant DNA damage DNA repair Hydrolase Isopeptide bond Magnesium Metal-binding Non-syndromic deafness Nucleus Phosphoprotein Protein phosphatase Reference proteome Transcription Transcription ... | MEDSQDLNEQ | MEDSQDLNEQSVKKTCTESDVSQSQNSRSMEMQDLASPHTLVGGGDTPGSSKLEKSNLSSTSVTTNGTGGENMTVLNTADWLLSCNTPSSATMSLLAVKTEPLNSSETTATTGDGALDTFTGSVITSSGYSPRSAHQYSPQLYPSKPYPHILSTPAAQTMSAYAGQTQYSGMQQPAVYTAYSQTGQPYSLPTYDLGVMLPAIKTESGLSQTQSPLQSGCLSYSPGFSTPQPGQTPYSYQMPGSSFAPSSTIYANNSVSNSTNFSGSQQDYPSYTAFGQNQYAQYYSASTYGAYMTSNNTADGTPSSTSTYQLQESLPGLT... | anatomical structure development anatomical structure morphogenesis cell differentiation chromatin organization DNA repair inner ear development negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of DNA repair visual perception cytoplasm; nucleus metal ion binding prot... |
hematopoietic progenitor cell differentiation intermediate filament organization keratinization | cornified envelope; cytosol; extracellular exosome; intermediate filament; keratin filament | structural constituent of skin epidermis structural molecule activity | Homo sapiens | Coiled coil Disease variant Intermediate filament Keratin Reference proteome | MSRQSSITFQ | MSRQSSITFQSGSRRGFSTTSAITPAAGRSRFSSVSVARSAAGSGGLGRISSAGASFGSRSLYNLGGAKRVSINGCGSSCRSGFGGRASNRFGVNSGFGYGGGVGGGFSGPSFPVCPPGGIQEVTVNQSLLTPLHLQIDPTIQRVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDSYTSELRRQLESITTERGRLEAELRNMQDVVEDFKVRYEDEINKRTAAENEFVALKKDVDAAYMNKVELEAKVKSLPEEINFIHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSII... | hematopoietic progenitor cell differentiation intermediate filament organization keratinization cornified envelope; cytosol; extracellular exosome; intermediate filament; keratin filament structural constituent of skin epidermis structural molecule activity Homo sapiens Coiled coil Disease variant Intermediate filament... |
cell projection organization microtubule anchoring negative regulation of protein kinase activity positive regulation of cell growth positive regulation of cell migration positive regulation of cell population proliferation | cell projection; centriole; centrosome; cytosol; nucleus; perinuclear region of cytoplasm | protein homodimerization activity protein kinase binding protein tyrosine kinase inhibitor activity | Homo sapiens | 3D-structure Alternative splicing Cell projection Chromosomal rearrangement Cilium biogenesis/degradation Cytoplasm Cytoskeleton Phosphoprotein Reference proteome | MAATAAAVVA | MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEGALDLSDVHSPPKSPEGKTSAQTTPSKIPRYKGQGKKKTSGQKAGDKKANDEANQSDTSVSLSEPKSKSSLHLLSHETKIGSFLSNRTLDGKDKAGLCPDEDDMEGDSFFDDPIPKPEKTYGLRKEPRKQAGSLASLSDAPPLKSGLSSLAGAPSLKDSESKRGNTVLKDLKLI... | cell projection organization microtubule anchoring negative regulation of protein kinase activity positive regulation of cell growth positive regulation of cell migration positive regulation of cell population proliferation cell projection; centriole; centrosome; cytosol; nucleus; perinuclear region of cytoplasm protei... |
positive regulation of protein secretion regulation of DNA-templated transcription | actin cytoskeleton; cytoplasm; cytosol; membrane; nuclear body; nucleus | amyloid-beta binding low-density lipoprotein particle receptor binding | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Nucleus Reference proteome Repeat | MLGKDYMLAI | MLGKDYMLAIILVNCDDDLWGDHSLEVEAGLPPGWRKIHDAAGTYYWHVPSGSTQWQRPTWELGDAEDPGTGTEGIWGLRPPKGRSFSSLESSLDRSNSLSWYGGESYIQSMEPGAKCFAVRSLGWVEVPEEDLAPGKSSIAVNNCIQQLAQTRSRSQPPDGAWGEGQNMLMILKKDAMSLVNPLDHSLIHCQPLVHIRVWGVGSSKGRDRDFAFVASDKDSCMLKCHVFCCDVPAKAIASALHGLCAQILSERVEVSGDASCCSPDPISPEDLPRQVELLDAVSQAAQKYEALYMGTLPVTKAMGMDVLNEAIGTLTAR... | positive regulation of protein secretion regulation of DNA-templated transcription actin cytoskeleton; cytoplasm; cytosol; membrane; nuclear body; nucleus amyloid-beta binding low-density lipoprotein particle receptor binding Homo sapiens 3D-structure Alternative splicing Cytoplasm Nucleus Reference proteome Repeat MLG... |
rRNA processing tRNA 5'-leader removal | multimeric ribonuclease P complex; nucleolus; nucleoplasm; ribonuclease MRP complex; ribonuclease P complex | ribonuclease P activity ribonuclease P RNA binding | Homo sapiens | 3D-structure Direct protein sequencing Nucleus Phosphoprotein Reference proteome RNA-binding tRNA processing | MKSVIYHALS | MKSVIYHALSQKEANDSDVQPSGAQRAEAFVRAFLKRSTPRMSPQAREDQLQRKAVVLEYFTRHKRKEKKKKAKGLSARQRRELRLFDIKPEQQRYSLFLPLHELWKQYIRDLCSGLKPDTQPQMIQAKLLKADLHGAIISVTKSKCPSYVGITGILLQETKHIFKIITKEDRLKVIPKLNCVFTVETDGFISYIYGSKFQLRSSERSAKKFKAKGTIDL | rRNA processing tRNA 5'-leader removal multimeric ribonuclease P complex; nucleolus; nucleoplasm; ribonuclease MRP complex; ribonuclease P complex ribonuclease P activity ribonuclease P RNA binding Homo sapiens 3D-structure Direct protein sequencing Nucleus Phosphoprotein Reference proteome RNA-binding tRNA processing ... |
antimicrobial humoral immune response mediated by antimicrobial peptide cell-cell signaling chemotaxis signal transduction | extracellular space; Golgi apparatus | chemokine activity | Homo sapiens | 3D-structure Chemotaxis Cytokine Direct protein sequencing Disulfide bond Reference proteome Secreted Signal Ubl conjugation | MSLLPRRAPP | MSLLPRRAPPVSMRLLAAALLLLLLALYTARVDGSKCKCSRKGPKIRYSDVKKLEMKPKYPHCEEKMVIITTKSVSRYRGQEHCLHPKLQSTKRFIKWYNAWNEKRRVYEE | antimicrobial humoral immune response mediated by antimicrobial peptide cell-cell signaling chemotaxis signal transduction extracellular space; Golgi apparatus chemokine activity Homo sapiens 3D-structure Chemotaxis Cytokine Direct protein sequencing Disulfide bond Reference proteome Secreted Signal Ubl conjugation MSL... |
bone resorption positive regulation of regulated secretory pathway protein localization to plasma membrane protein secretion regulation of exocytosis vesicle docking involved in exocytosis | azurophil granule membrane; cytoplasmic microtubule; endosome; extracellular exosome; plasma membrane; secretory vesicle; synaptic vesicle; zymogen granule | GTP binding GTP-dependent protein binding GTPase activity myosin V binding | Homo sapiens | 3D-structure Acetylation Cell membrane Exocytosis GTP-binding Lipoprotein Membrane Methylation Nucleotide-binding Phosphoprotein Prenylation Protein transport Reference proteome Transport | MASAGDTQAG | MASAGDTQAGPRDAADQNFDYMFKLLLIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTVYRHDKRIKLQIWDTAGQERYRTITTAYYRGAMGFLLMYDIANQESFAAVQDWATQIKTYSWDNAQVILVGNKCDLEDERVVPAEDGRRLADDLGFEFFEASAKENINVKQVFERLVDVICEKMNESLEPSSSSGSNGKGPAVGDAPAPQPSSCSC | bone resorption positive regulation of regulated secretory pathway protein localization to plasma membrane protein secretion regulation of exocytosis vesicle docking involved in exocytosis azurophil granule membrane; cytoplasmic microtubule; endosome; extracellular exosome; plasma membrane; secretory vesicle; synaptic ... |
cell dedifferentiation cell population proliferation inner ear development intracellular steroid hormone receptor signaling pathway negative regulation of stem cell differentiation photoreceptor cell maintenance positive regulation of DNA-templated transcription positive regulation of stem cell population maintenance p... | chromatin; condensed chromosome; cytoplasm; cytosol; nucleoplasm; nucleus | cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific estrogen response element binding nuclear receptor activity nuclear steroid recepto... | Homo sapiens | 3D-structure Acetylation Alternative splicing Chromosome Cytoplasm Deafness Disease variant DNA-binding Metal-binding Non-syndromic deafness Nucleus Receptor Reference proteome Transcription Transcription regulation Zinc Zinc-finger | MSSDDRHLGS | MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLEL... | cell dedifferentiation cell population proliferation inner ear development intracellular steroid hormone receptor signaling pathway negative regulation of stem cell differentiation photoreceptor cell maintenance positive regulation of DNA-templated transcription positive regulation of stem cell population maintenance p... |
autophagosome maturation autophagosome membrane docking cilium assembly exocytosis membrane fusion protein transport synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle priming vesicle targeting | autophagosome; autophagosome membrane; azurophil granule membrane; centrosome; ciliary pocket membrane; cytoplasm; cytosol; Golgi membrane; plasma membrane; presynapse; SNARE complex | SNAP receptor activity syntaxin binding | Homo sapiens | 3D-structure Autophagy Cell membrane Cell projection Cilium Cilium biogenesis/degradation Coiled coil Cytoplasm Cytoplasmic vesicle Golgi apparatus Ichthyosis Membrane Neuropathy Palmoplantar keratoderma Phosphoprotein Protein transport Reference proteome Transport | MSAYPKSYNP | MSAYPKSYNPFDDDGEDEGARPAPWRDARDLPDGPDAPADRQQYLRQEVLRRAEATAASTSRSLALMYESEKVGVASSEELARQRGVLERTEKMVDKMDQDLKISQKHINSIKSVFGGLVNYFKSKPVETPPEQNGTLTSQPNNRLKEAISTSKEQEAKYQASHPNLRKLDDTDPVPRGAGSAMSTDAYPKNPHLRAYHQKIDSNLDELSMGLGRLKDIALGMQTEIEEQDDILDRLTTKVDKLDVNIKSTERKVRQL | autophagosome maturation autophagosome membrane docking cilium assembly exocytosis membrane fusion protein transport synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle priming vesicle targeting autophagosome; autophagosome membrane; azurophil granule membrane; centrosome; ciliary pocket membra... |
adaptive immune response cell recognition detection of stimulus detection of tumor cell establishment of T cell polarity heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules lymphocyte migration into lymphoid organs negative regulation of activated T cell proliferation positive regulation of cyto... | immunological synapse; plasma membrane | identical protein binding signaling receptor binding | Homo sapiens | 3D-structure Adaptive immunity Alternative splicing Cell adhesion Cell membrane Disulfide bond Glycoprotein Immunity Immunoglobulin domain Membrane Reference proteome Repeat Signal Transmembrane Transmembrane helix | MWWRVLSLLA | MWWRVLSLLAWFPLQEASLTNHTETITVEEGQTLTLKCVTSLRKNSSLQWLTPSGFTIFLNEYPALKNSKYQLLHHSANQLSITVPNVTLQDEGVYKCLHYSDSVSTKEVKVIVLATPFKPILEASVIRKQNGEEHVVLMCSTMRSKPPPQITWLLGNSMEVSGGTLHEFETDGKKCNTTSTLIIHTYGKNSTVDCIIRHRGLQGRKLVAPFRFEDLVTDEETASDALERNSLSSQDPQQPTSTVSVTEDSSTSEIDKEEKEQTTQDPDLTTEANPQYLGLARKKSGILLLTLVSFLIFILFIIVQLFIMKLRKAHVIWK... | adaptive immune response cell recognition detection of stimulus detection of tumor cell establishment of T cell polarity heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules lymphocyte migration into lymphoid organs negative regulation of activated T cell proliferation positive regulation of cyto... |
cell differentiation cellular response to calcium ion positive regulation of dendrite extension postsynaptic actin cytoskeleton organization | axon; clathrin-coated endocytic vesicle; dendrite; endosome; extracellular exosome; membrane; perikaryon; plasma membrane | calcium ion binding calcium-dependent phospholipid binding phosphatidylserine binding | Homo sapiens | Alternative splicing Calcium Cell membrane Cell projection Cytoplasm Cytoplasmic vesicle Differentiation Endosome Membrane Metal-binding Reference proteome Repeat | MSDPEMGWVP | MSDPEMGWVPEPPTMTLGASRVELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLALEYFFEEKQPLQFHVFDAEDGATSPRNDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKSTITIVAEEVSGTNDYVQLTFRAYKLDNKDLFSKSDPFMEIYKTNEDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCDVHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDP... | cell differentiation cellular response to calcium ion positive regulation of dendrite extension postsynaptic actin cytoskeleton organization axon; clathrin-coated endocytic vesicle; dendrite; endosome; extracellular exosome; membrane; perikaryon; plasma membrane calcium ion binding calcium-dependent phospholipid bindin... |
cell volume homeostasis cellular hyperosmotic response cellular hypotonic response cellular response to chemokine chemokine (C-C motif) ligand 21 signaling pathway chemokine (C-X-C motif) ligand 12 signaling pathway intracellular signal transduction negative regulation of potassium ion transmembrane transport osmosenso... | cytoplasm; cytosol; extracellular exosome | ATP binding identical protein binding magnesium ion binding protein kinase binding protein serine kinase activity protein serine/threonine kinase activity | Homo sapiens | 3D-structure Acetylation ATP-binding Cytoplasm Kinase Magnesium Metal-binding Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase | MSEDSSALPW | MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRR... | cell volume homeostasis cellular hyperosmotic response cellular hypotonic response cellular response to chemokine chemokine (C-C motif) ligand 21 signaling pathway chemokine (C-X-C motif) ligand 12 signaling pathway intracellular signal transduction negative regulation of potassium ion transmembrane transport osmosenso... |
farnesyl diphosphate biosynthetic process geranyl diphosphate biosynthetic process geranylgeranyl diphosphate biosynthetic process isoprenoid biosynthetic process isoprenoid metabolic process | cytoplasm; cytosol; nucleoplasm; perinuclear region of cytoplasm; Z disc | dimethylallyltranstransferase activity farnesyltranstransferase activity geranyltranstransferase activity identical protein binding metal ion binding prenyltransferase activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Congenital muscular dystrophy Cytoplasm Deafness Disease variant Isoprene biosynthesis Lipid metabolism Magnesium Metal-binding Reference proteome Transferase | MEKTQETVQR | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE | farnesyl diphosphate biosynthetic process geranyl diphosphate biosynthetic process geranylgeranyl diphosphate biosynthetic process isoprenoid biosynthetic process isoprenoid metabolic process cytoplasm; cytosol; nucleoplasm; perinuclear region of cytoplasm; Z disc dimethylallyltranstransferase activity farnesyltranstra... |
animal organ morphogenesis cell differentiation fibroblast growth factor receptor signaling pathway negative regulation of bile acid biosynthetic process negative regulation of gene expression nervous system development positive regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade po... | cytoplasm; extracellular region; extracellular space | fibroblast growth factor receptor binding growth factor activity | Homo sapiens | 3D-structure Direct protein sequencing Disulfide bond Growth factor Reference proteome Secreted Signal | MRSGCVVVHV | MRSGCVVVHVWILAGLWLAVAGRPLAFSDAGPHVHYGWGDPIRLRHLYTSGPHGLSSCFLRIRADGVVDCARGQSAHSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQYSEEDCAFEEEIRPDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFLPLSHFLPMLPMVPEEPEDLRGHLESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEK | animal organ morphogenesis cell differentiation fibroblast growth factor receptor signaling pathway negative regulation of bile acid biosynthetic process negative regulation of gene expression nervous system development positive regulation of cell population proliferation positive regulation of ERK1 and ERK2 cascade po... |
axon guidance cell-cell signaling negative chemotaxis negative regulation of axon extension involved in axon guidance nervous system development neural crest cell migration positive regulation of cell migration retinal ganglion cell axon guidance semaphorin-plexin signaling pathway | dendrite; endoplasmic reticulum; glutamatergic synapse; membrane; perikaryon; plasma membrane; postsynaptic density membrane | chemorepellent activity semaphorin receptor binding | Homo sapiens | Alternative splicing Cell membrane Cell projection Developmental protein Differentiation Disulfide bond Glycoprotein Immunoglobulin domain Membrane Neurogenesis Phosphoprotein Reference proteome Signal Synapse Transmembrane Transmembrane helix | MPASAARPRP | MPASAARPRPGPGQPTASPFPLLLLAVLSGPVSGRVPRSVPRTSLPISEADSCLTRFAVPHTYNYSVLLVDPASHTLYVGARDTIFALSLPFSGERPRRIDWMVPEAHRQNCRKKGKKEDECHNFVQILAIANASHLLTCGTFAFDPKCGVIDVSRFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYAATVKNYLGTEPIITRAVGRAEDWIRTDTLPSWLNAPAFVAAVALSPAEWGDEDGDDEIYFFFTETSRAFDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASSVLQDVAVLRPELG... | axon guidance cell-cell signaling negative chemotaxis negative regulation of axon extension involved in axon guidance nervous system development neural crest cell migration positive regulation of cell migration retinal ganglion cell axon guidance semaphorin-plexin signaling pathway dendrite; endoplasmic reticulum; glut... |
anatomical structure morphogenesis erythrocyte maturation mRNA processing negative regulation of RNA splicing regulation of cell differentiation regulation of RNA splicing RNA splicing | nucleus | mRNA binding RNA binding | Homo sapiens | Acetylation Alternative splicing Differentiation Erythrocyte maturation Isopeptide bond mRNA processing mRNA splicing Phosphoprotein Reference proteome Repeat Repressor RNA-binding Ubl conjugation | MDGVVTDLIT | MDGVVTDLITVGLKRGSDELLSSGIINGPFTMNSSTPSTANGNDSKKFKRDRPPCSPSRVLHLRKIPCDVTEAEIISLGLPFGKVTNLLMLKGKSQAFLEMASEEAAVTMVNYYTPITPHLRSQPVYIQYSNHRELKTDNLPNQARAQAALQAVSAVQSGSLALSGGPSNEGTVLPGQSPVLRIIIENLFYPVTLEVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVNAHYAKMALDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDFTRLDLPTGDGQPSLEPPMAAAFGAPGIISSPYAGAAGFAPAIGFPQA... | anatomical structure morphogenesis erythrocyte maturation mRNA processing negative regulation of RNA splicing regulation of cell differentiation regulation of RNA splicing RNA splicing nucleus mRNA binding RNA binding Homo sapiens Acetylation Alternative splicing Differentiation Erythrocyte maturation Isopeptide bond m... |
cholesterol transport vesicle tethering to endoplasmic reticulum | cytosol; endoplasmic reticulum-endosome membrane contact site; endosome; intracellular membrane-bounded organelle; late endosome membrane; lysosomal membrane; membrane; organelle membrane contact site | cholesterol binding protein homodimerization activity | Homo sapiens | Acetylation Alternative initiation Endosome Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix | MNHLPEDMEN | MNHLPEDMENALTGSQSSHASLRNIHSINPTQLMARIESYEGREKKGISDVRRTFCLFVTFDLLFVTLLWIIELNVNGGIENTLEKEVMQYDYYSSYFDIFLLAVFRFKVLILAYAVCRLRHWWAIALTTAVTSAFLLAKVILSKLFSQGAFGYVLPIISFILAWIETWFLDFKVLPQEAEEENRLLIVQDASERAALIPGGLSDGQFYSPPESEAGSEEAEEKQDSEKPLLEL | cholesterol transport vesicle tethering to endoplasmic reticulum cytosol; endoplasmic reticulum-endosome membrane contact site; endosome; intracellular membrane-bounded organelle; late endosome membrane; lysosomal membrane; membrane; organelle membrane contact site cholesterol binding protein homodimerization activity ... |
mRNA splicing, via spliceosome | Lsm2-8 complex; nucleoplasm; nucleus; precatalytic spliceosome; U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex; U6 snRNP | RNA binding U6 snRNA binding | Homo sapiens | 3D-structure Acetylation Direct protein sequencing mRNA processing mRNA splicing Nucleus Reference proteome Ribonucleoprotein RNA-binding Spliceosome | MTSALENYIN | MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH | mRNA splicing, via spliceosome Lsm2-8 complex; nucleoplasm; nucleus; precatalytic spliceosome; U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex; U6 snRNP RNA binding U6 snRNA binding Homo sapiens 3D-structure Acetylation Direct protein sequencing mRNA processing mRNA splicing Nucleus Reference proteome Ri... |
clathrin-dependent endocytosis endocytosis Golgi to endosome transport intracellular protein transport negative regulation of hyaluronan biosynthetic process positive regulation of neuron projection development positive regulation of receptor-mediated endocytosis postsynaptic neurotransmitter receptor internalization v... | AP-2 adaptor complex; apical plasma membrane; basolateral plasma membrane; clathrin coat of trans-Golgi network vesicle; clathrin-coated endocytic vesicle; clathrin-coated endocytic vesicle membrane; cytoplasmic side of plasma membrane; cytosol; endocytic vesicle membrane; endolysosome membrane; filopodium tip; membran... | clathrin adaptor activity low-density lipoprotein particle receptor binding protein kinase binding protein-containing complex binding | Homo sapiens | Alternative splicing Cell membrane Coated pit Endocytosis Membrane Phosphoprotein Protein transport Reference proteome Transport | MPAVSKGDGM | MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVVTAAVSLITCLCKKNPDDFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPEDAAVKGRLVECLETVLNKAQEPPKSKKVQHSNAKNAILFETISLIIHY... | clathrin-dependent endocytosis endocytosis Golgi to endosome transport intracellular protein transport negative regulation of hyaluronan biosynthetic process positive regulation of neuron projection development positive regulation of receptor-mediated endocytosis postsynaptic neurotransmitter receptor internalization v... |
anterograde dendritic transport of messenger ribonucleoprotein complex cellular response to oxidative stress germ cell development intracellular mRNA localization lncRNA-mediated post-transcriptional gene silencing modification of postsynaptic structure positive regulation by virus of viral protein levels in host cell ... | cell body; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoplasmic stress granule; cytosol; dendrite; dendrite cytoplasm; endoplasmic reticulum; extracellular exosome; glutamatergic synapse; membrane; messenger ribonucleoprotein complex; microtubule associated complex; neuron projection; neuronal cell body; plasm... | double-stranded RNA binding mRNA binding protein phosphatase 1 binding RNA binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Endoplasmic reticulum Host-virus interaction Methylation Phosphoprotein Reference proteome Repeat RNA-binding | MSQVQVQVQN | MSQVQVQVQNPSAALSGSQILNKNQSLLSQPLMSIPSTTSSLPSENAGRPIQNSALPSASITSTSAAAESITPTVELNALCMKLGKKPMYKPVDPYSRMQSTYNYNMRGGAYPPRYFYPFPVPPLLYQVELSVGGQQFNGKGKTRQAAKHDAAAKALRILQNEPLPERLEVNGRESEEENLNKSEISQVFEIALKRNLPVNFEVARESGPPHMKNFVTKVSVGEFVGEGEGKSKKISKKNAAIAVLEELKKLPPLPAVERVKPRIKKKTKPIVKPQTSPEYGQGINPISRLAQIQQAKKEKEPEYTLLTERGLPRRREFV... | anterograde dendritic transport of messenger ribonucleoprotein complex cellular response to oxidative stress germ cell development intracellular mRNA localization lncRNA-mediated post-transcriptional gene silencing modification of postsynaptic structure positive regulation by virus of viral protein levels in host cell ... |
defense response to virus innate immune response protein folding | cytoplasm; nucleoplasm; nucleus | Hsp70 protein binding Hsp90 protein binding | Homo sapiens | 3D-structure Acetylation Antiviral defense Cytoplasm Immunity Innate immunity Nucleus Phosphoprotein Reference proteome Repeat TPR repeat | MEQPGQDPTS | MEQPGQDPTSDDVMDSFLEKFQSQPYRGGFHEDQWEKEFEKVPLFMSRAPSEIDPRENPDLACLQSIIFDEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKKKCADPDLNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKADKLKRIEQRDVRKANLKEKKERNQNEALLQAIKARNIRLSEAACEDEDSASEGLGELFLDGLSTENPHGARLSLDGQGRLSWPVLFLYPEYAQSDFISAFHEDSRFIDHLMVMFGETPSWDLEQKY... | defense response to virus innate immune response protein folding cytoplasm; nucleoplasm; nucleus Hsp70 protein binding Hsp90 protein binding Homo sapiens 3D-structure Acetylation Antiviral defense Cytoplasm Immunity Innate immunity Nucleus Phosphoprotein Reference proteome Repeat TPR repeat MEQPGQDPTS MEQPGQDPTSDDVMDSF... |
heparan sulfate proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process heparin biosynthetic process | Golgi apparatus; Golgi membrane | -glucosamine N-sulfotransferase activity deacetylase activity heparan sulfate N-deacetylase activity | Homo sapiens | Alternative splicing Disulfide bond Glycoprotein Golgi apparatus Hydrolase Membrane Multifunctional enzyme Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix | MSFIMKLHRH | MSFIMKLHRHFQRTVILLATFCMVSIIISAYYLYSGYKQENELSETASEVDCGDLQHLPYQLMEVKAMKLFDASRTDPTVLVFVESQYSSLGQDIIMILESSRFQYHIEIAPGKGDLPVLIDKMKGKYILIIYENILKYINMDSWNRSLLDKYCVEYGVGVIGFHKTSEKSVQSFQLKGFPFSIYGNLAVKDCCINPHSPLIRVTKSSKLEKGSLPGTDWTVFQINHSAYQPVIFAKVKTPENLSPSISKGAFYATIIHDLGLHDGIQRVLFGNNLNFWLHKLIFIDAISFLSGKRLTLSLDRYILVDIDDIFVGKEGTR... | heparan sulfate proteoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process heparin biosynthetic process Golgi apparatus; Golgi membrane -glucosamine N-sulfotransferase activity deacetylase activity heparan sulfate N-deacetylase activity Homo sapiens Al... |
plasma membrane tubulation | caveola; cytoplasm; cytosol; membrane raft; nucleoplasm; plasma membrane | phosphatidylserine binding phospholipid binding protein kinase C binding | Homo sapiens | Acetylation Coiled coil Cytoplasm Direct protein sequencing Lipid-binding Membrane Phosphoprotein Reference proteome | MGEDAAQAEK | MGEDAAQAEKFQHPGSDMRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPS... | plasma membrane tubulation caveola; cytoplasm; cytosol; membrane raft; nucleoplasm; plasma membrane phosphatidylserine binding phospholipid binding protein kinase C binding Homo sapiens Acetylation Coiled coil Cytoplasm Direct protein sequencing Lipid-binding Membrane Phosphoprotein Reference proteome MGEDAAQAEK MGEDAA... |
anterior/posterior axis specification anterior/posterior pattern specification bone mineralization cell migration involved in gastrulation cellular response to cadmium ion determination of dorsal identity determination of heart left/right asymmetry gastrulation growth plate cartilage chondrocyte proliferation negative ... | extracellular region; extracellular space | BMP binding cytokine activity morphogen activity protein homodimerization activity | Homo sapiens | Cytokine Direct protein sequencing Disulfide bond Glycoprotein Reference proteome Secreted Signal | MHLLLFQLLV | MHLLLFQLLVLLPLGKTTRHQDGRQNQSSLSPVLLPRNQRELPTGNHEEAEEKPDLFVAVPHLVATSPAGEGQRQREKMLSRFGRFWKKPEREMHPSRDSDSEPFPPGTQSLIQPIDGMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHEVHWETCRTVPFSQTITHEGCEKVVVQNNLCFGKCGSVHFPGAAQHSHTSCSHCLPAKFTTMHLPLNCTELSSVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA | anterior/posterior axis specification anterior/posterior pattern specification bone mineralization cell migration involved in gastrulation cellular response to cadmium ion determination of dorsal identity determination of heart left/right asymmetry gastrulation growth plate cartilage chondrocyte proliferation negative ... |
negative regulation of protein binding negative regulation of protein ubiquitination negative regulation of ubiquitin protein ligase activity positive regulation of proteasomal protein catabolic process positive regulation of protein processing protein folding protein metabolic process protein stabilization | axon; cytosol; dendrite; dendritic microtubule; protein folding chaperone complex | adenyl-nucleotide exchange factor activity heat shock protein binding identical protein binding protein-folding chaperone binding tau protein binding transmembrane transporter binding ubiquitin protein ligase binding | Homo sapiens | Acetylation Alternative splicing Chaperone Coiled coil Phosphoprotein Reference proteome | MAQAKINAKA | MAQAKINAKANEGRFCRSSSMADRSSRLLESLDQLELRVEALREAATAVEQEKEILLEMIHSIQNSQDMRQISDGEREELNLTANRLMGRTLTVEVSVETIRNPQQQESLKHATRIIDEVVNKFLDDLGNAKSHLMSLYSACSSEVPHGPVDQKFQSIVIGCALEDQKKIKRRLETLLRNIENSDKAIKLLEHSKGAGSKTLQQNAESRFN | negative regulation of protein binding negative regulation of protein ubiquitination negative regulation of ubiquitin protein ligase activity positive regulation of proteasomal protein catabolic process positive regulation of protein processing protein folding protein metabolic process protein stabilization axon; cytos... |
aggresome assembly autophagosome assembly cellular response to heat cellular response to mechanical stimulus cellular response to unfolded protein chaperone-mediated autophagy extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway via death domain receptors muscle cell cellular... | aggresome; cytoplasm; cytosol; membrane; nucleoplasm; nucleus; protein folding chaperone complex; stress fiber; Z disc | adenyl-nucleotide exchange factor activity cadherin binding dynein intermediate chain binding protein carrier chaperone protein-containing complex binding protein-folding chaperone binding | Homo sapiens | Acetylation Apoptosis Cardiomyopathy Chaperone Cytoplasm Disease variant Isopeptide bond Methylation Myofibrillar myopathy Nucleus Phosphoprotein Reference proteome Repeat Ubl conjugation | MSAATHSPMM | MSAATHSPMMQVASGNGDRDPLPPGWEIKIDPQTGWPFFVDHNSRTTTWNDPRVPSEGPKETPSSANGPSREGSRLPPAREGHPVYPQLRPGYIPIPVLHEGAENRQVHPFHVYPQPGMQRFRTEAAAAAPQRSQSPLRGMPETTQPDKQCGQVAAAAAAQPPASHGPERSQSPAASDCSSSSSSASLPSSGRSSLGSHQLPRGYISIPVIHEQNVTRPAAQPSFHQAQKTHYPAQQGEYQTHQPVYHKIQGDDWEPRPLRAASPFRSSVQGASSREGSPARSSTPLHSPSPIRVHTVVDRPQQPMTHRETAPVSQPENK... | aggresome assembly autophagosome assembly cellular response to heat cellular response to mechanical stimulus cellular response to unfolded protein chaperone-mediated autophagy extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway via death domain receptors muscle cell cellular... |
acetyl-CoA biosynthetic process acyl-CoA metabolic process fatty acid biosynthetic process fatty acid oxidation malonyl-CoA catabolic process positive regulation of fatty acid oxidation regulation of fatty acid beta-oxidation regulation of glucose metabolic process response to ischemia response to nutrient | cytoplasm; cytosol; mitochondrial matrix; mitochondrion; peroxisomal matrix; peroxisome | identical protein binding malonyl-CoA decarboxylase activity | Homo sapiens | 3D-structure Acetylation Alternative initiation Cytoplasm Decarboxylase Disulfide bond Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism Lyase Mitochondrion Peroxisome Reference proteome Transit peptide | MRGFGPGLTA | MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFP... | acetyl-CoA biosynthetic process acyl-CoA metabolic process fatty acid biosynthetic process fatty acid oxidation malonyl-CoA catabolic process positive regulation of fatty acid oxidation regulation of fatty acid beta-oxidation regulation of glucose metabolic process response to ischemia response to nutrient cytoplasm; c... |
activation of cysteine-type endopeptidase activity involved in apoptotic process apoptotic process cellular response to aldosterone cellular response to estradiol stimulus cellular response to hydrogen peroxide cellular response to hypoxia cellular response to nitric oxide chromosome condensation intrinsic apoptotic si... | cytoplasm; cytosol; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion; nucleus; perinuclear region of cytoplasm | DNA binding FAD binding NAD(P)H oxidase H2O2-forming activity NADH dehydrogenase activity oxidoreductase activity, acting on NAD(P)H poly-ADP-D-ribose binding protein dimerization activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Apoptosis Charcot-Marie-Tooth disease Cytoplasm Deafness Direct protein sequencing Disease variant DNA-binding Dwarfism FAD Flavoprotein Intellectual disability Isopeptide bond Membrane Mitochondrion Mitochondrion inner membrane NAD Neurodegeneration Neuropathy Nucleus Oxid... | MFRCGGLAAG | MFRCGGLAAGALKQKLVPLVRTVCVRSPRQRNRLPGNLFQRWHVPLELQMTRQMASSGASGGKIDNSVLVLIVGLSTVGAGAYAYKTMKEDEKRYNERISGLGLTPEQKQKKAALSASEGEEVPQDKAPSHVPFLLIGGGTAAFAAARSIRARDPGARVLIVSEDPELPYMRPPLSKELWFSDDPNVTKTLRFKQWNGKERSIYFQPPSFYVSAQDLPHIENGGVAVLTGKKVVQLDVRDNMVKLNDGSQITYEKCLIATGGTPRSLSAIDRAGAEVKSRTTLFRKIGDFRSLEKISREVKSITIIGGGFLGSELACALG... | activation of cysteine-type endopeptidase activity involved in apoptotic process apoptotic process cellular response to aldosterone cellular response to estradiol stimulus cellular response to hydrogen peroxide cellular response to hypoxia cellular response to nitric oxide chromosome condensation intrinsic apoptotic si... |
bicellular tight junction assembly calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell adhesion cell junction maintenance cell-cell junction organization cellular response to butyrate cellular response to lead ion cellular response to transforming growth factor beta stimulus cellular... | apical plasma membrane; basolateral plasma membrane; bicellular tight junction; lateral plasma membrane; membrane; plasma membrane; protein-containing complex; tight junction | identical protein binding structural molecule activity virus receptor activity | Homo sapiens | Cell junction Cell membrane Disulfide bond Host cell receptor for virus entry Host-virus interaction Ichthyosis Membrane Receptor Reference proteome Tight junction Transmembrane Transmembrane helix | MANAGLQLLG | MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTGQIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAVIGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLCCSCPRKTTSYPTPRPYPKPAPSSGKDYV | bicellular tight junction assembly calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell adhesion cell junction maintenance cell-cell junction organization cellular response to butyrate cellular response to lead ion cellular response to transforming growth factor beta stimulus cellular... |
chloride transport signal transduction | chloride channel complex; cytoplasm; extracellular exosome; membrane; nuclear body; nucleus | chloride channel activity | Homo sapiens | 3D-structure Chloride Chloride channel Cytoplasm Disulfide bond Ion channel Ion transport Membrane Nucleus Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport Voltage-gated channel | MAETKLQLFV | MAETKLQLFVKASEDGESVGHCPSCQRLFMVLLLKGVPFTLTTVDTRRSPDVLKDFAPGSQLPILLYDSDAKTDTLQIEDFLEETLGPPDFPSLAPRYRESNTAGNDVFHKFSAFIKNPVPAQDEALYQQLLRALARLDSYLRAPLEHELAGEPQLRESRRRFLDGDRLTLADCSLLPKLHIVDTVCAHFRQAPIPAELRGVRRYLDSAMQEKEFKYTCPHSAEILAAYRPAVHPR | chloride transport signal transduction chloride channel complex; cytoplasm; extracellular exosome; membrane; nuclear body; nucleus chloride channel activity Homo sapiens 3D-structure Chloride Chloride channel Cytoplasm Disulfide bond Ion channel Ion transport Membrane Nucleus Phosphoprotein Reference proteome Transmemb... |
microtubule cytoskeleton organization negative regulation of microtubule polymerization regulation of microtubule nucleation sensory perception of sound visual perception | cytoplasm; microtubule; microtubule associated complex; spindle | microtubule binding protein self-association tubulin binding | Homo sapiens | 3D-structure Alternative splicing Coiled coil Cytoplasm Cytoskeleton Microtubule Reference proteome Repeat WD repeat | MSSFGAGKTK | MSSFGAGKTKEVIFSVEDGSVKMFLRGRPVPMMIPDELAPTYSLDTRSELPSCRLKLEWVYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGHNDDIKCLAIHPDMVTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVCCVGFSKSNGGNLLCAVDESNDHMLSVWDWAKETKVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTLEGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVLGAHDGGVFGLCALRDGTLVSGGGRDRRVVL... | microtubule cytoskeleton organization negative regulation of microtubule polymerization regulation of microtubule nucleation sensory perception of sound visual perception cytoplasm; microtubule; microtubule associated complex; spindle microtubule binding protein self-association tubulin binding Homo sapiens 3D-structur... |
action potential adenylate cyclase-modulating G protein-coupled receptor signaling pathway phospholipase C-activating dopamine receptor signaling pathway signal transduction | extracellular exosome; heterotrimeric G-protein complex; plasma membrane | G protein-coupled receptor binding G-protein beta/gamma-subunit complex binding GTP binding GTPase activity metal ion binding | Homo sapiens | ADP-ribosylation GTP-binding Magnesium Metal-binding Nucleotide-binding Reference proteome Transducer | MAGCCCLSAE | MAGCCCLSAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDRKGFTKLVYQNIFTAMQAMIRAMDTLRIQYVCEQNKENAQIIREVEVDKVSMLSREQVEAIKQLWQDPGIQECYDRRREYQLSDSAKYYLTDIDRIATPSFVPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFESVTSIIFLVALSEYDQVLAECDNENRMEESKALFKTIITYPWFLNSSVILFLNKKDLLEEKIMYSHLISYFPEYTGPKQDVRAARDFILKLYQDQNPDKEKVI... | action potential adenylate cyclase-modulating G protein-coupled receptor signaling pathway phospholipase C-activating dopamine receptor signaling pathway signal transduction extracellular exosome; heterotrimeric G-protein complex; plasma membrane G protein-coupled receptor binding G-protein beta/gamma-subunit complex b... |
signal transduction visual perception | photoreceptor disc membrane | calcium ion binding calcium sensitive guanylate cyclase activator activity | Homo sapiens | 3D-structure Alternative splicing Calcium Lipoprotein Metal-binding Myristate Reference proteome Repeat | MGNGKSIAGD | MGNGKSIAGDQKAVPTQETHVWYRTFMMEYPSGLQTLHEFKTLLGLQGLNQKANKHIDQVYNTFDTNKDGFVDFLEFIAAVNLIMQEKMEQKLKWYFKLYDADGNGSIDKNELLDMFMAVQALNGQQTLSPEEFINLVFHKIDINNDGELTLEEFINGMAKDQDLLEIVYKSFDFSNVLRVICNGKQPDMETDSSKSPDKAGLGKVKMK | signal transduction visual perception photoreceptor disc membrane calcium ion binding calcium sensitive guanylate cyclase activator activity Homo sapiens 3D-structure Alternative splicing Calcium Lipoprotein Metal-binding Myristate Reference proteome Repeat MGNGKSIAGD MGNGKSIAGDQKAVPTQETHVWYRTFMMEYPSGLQTLHEFKTLLGLQGLNQ... |
inner ear development intracellular triglyceride homeostasis negative regulation of mitochondrial calcium ion concentration negative regulation of mitochondrial membrane potential negative regulation of neuron apoptotic process positive regulation of cell population proliferation regulation of glucose import response t... | apical part of cell; mitochondrial inner membrane; mitochondrial membrane; mitochondrion; neuronal cell body | chloride transmembrane transporter activity protein homodimerization activity proton transmembrane transporter activity transmembrane transporter activity | Homo sapiens | Alternative splicing Membrane Mitochondrion Mitochondrion inner membrane Reference proteome Repeat Transmembrane Transmembrane helix Transport | MSVPEEEERL | MSVPEEEERLLPLTQRWPRASKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGARESAPYRGMVRTALGIIEEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDEHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRKLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWVPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNIMTHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSTDCLIQAVQGEGFMSLYKGFLPSWLRMTPWSMVFWLTYEKIREMSGV... | inner ear development intracellular triglyceride homeostasis negative regulation of mitochondrial calcium ion concentration negative regulation of mitochondrial membrane potential negative regulation of neuron apoptotic process positive regulation of cell population proliferation regulation of glucose import response t... |
nucleoside phosphate metabolic process protein N-linked glycosylation via asparagine ribose phosphate metabolic process | cytosol | ADP-ribose diphosphatase activity identical protein binding metal ion binding UDP-sugar diphosphatase activity | Homo sapiens | 3D-structure Cytoplasm Hydrolase Magnesium Reference proteome | MERIEGASVG | MERIEGASVGRCAASPYLRPLTLHYRQNGAQKSWDFMKTHDSVTVLLFNSSRRSLVLVKQFRPAVYAGEVERRFPGSLAAVDQDGPRELQPALPGSAGVTVELCAGLVDQPGLSLEEVACKEAWEECGYHLAPSDLRRVATYWSGVGLTGSRQTMFYTEVTDAQRSGPGGGLVEEGELIEVVHLPLEGAQAFADDPDIPKTLGVIFGVSWFLSQVAPNLDLQ | nucleoside phosphate metabolic process protein N-linked glycosylation via asparagine ribose phosphate metabolic process cytosol ADP-ribose diphosphatase activity identical protein binding metal ion binding UDP-sugar diphosphatase activity Homo sapiens 3D-structure Cytoplasm Hydrolase Magnesium Reference proteome MERIEG... |
negative regulation of Notch signaling pathway protein localization to plasma membrane protein maturation regulation of membrane protein ectodomain proteolysis | cell junction; cell surface; cytosol; endoplasmic reticulum lumen; intracellular membrane-bounded organelle; late endosome membrane; nuclear body; plasma membrane; tetraspanin-enriched microdomain | enzyme binding | Homo sapiens | 3D-structure Cell membrane Disulfide bond Endosome Glycoprotein Membrane Reference proteome Transmembrane Transmembrane helix | MPRGDSEQVR | MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWLIGALVLSVGIYAEVERQKYKTLESAFLAPAIILILLGVVMFMVSFIGVLASLRDNLYLLQAFMYILGICLIMELIGGVVALTFRNQTIDFLNDNIRRGIENYYDDLDFKNIMDFVQKKFKCCGGEDYRDWSKNQYHDCSAPGPLACGVPYTCCIRNTTEVVNTMCGYKTIDKERFSVQDVIYVRGCTNAVIIWFMDNYTIMAGILLGILLPQFLGVLLTLLYITRVEDIIMEHSVTDGLLGPGAKPSVEAAGTGCCLCYPN | negative regulation of Notch signaling pathway protein localization to plasma membrane protein maturation regulation of membrane protein ectodomain proteolysis cell junction; cell surface; cytosol; endoplasmic reticulum lumen; intracellular membrane-bounded organelle; late endosome membrane; nuclear body; plasma membra... |
3'-phosphoadenosine 5'-phosphosulfate metabolic process nervous system development nucleobase-containing compound metabolic process phosphatidylinositol phosphate biosynthetic process | cytosol | 3'(2'),5'-bisphosphate nucleotidase activity metal ion binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Hydrolase Lithium Magnesium Metal-binding Phosphoprotein Reference proteome | MASSNTVLMR | MASSNTVLMRLVASAYSIAQKAGMIVRRVIAEGDLGIVEKTCATDLQTKADRLAQMSICSSLARKFPKLTIIGEEDLPSEEVDQELIEDSQWEEILKQPCPSQYSAIKEEDLVVWVDPLDGTKEYTEGLLDNVTVLIGIAYEGKAIAGVINQPYYNYEAGPDAVLGRTIWGVLGLGAFGFQLKEVPAGKHIITTTRSHSNKLVTDCVAAMNPDAVLRVGGAGNKIIQLIEGKASAYVFASPGCKKWDTCAPEVILHAVGGKLTDIHGNVLQYHKDVKHMNSAGVLATLRNYDYYASRVPESIKNALVP | 3'-phosphoadenosine 5'-phosphosulfate metabolic process nervous system development nucleobase-containing compound metabolic process phosphatidylinositol phosphate biosynthetic process cytosol 3'(2'),5'-bisphosphate nucleotidase activity metal ion binding Homo sapiens 3D-structure Acetylation Alternative splicing Hydrol... |
alpha-linolenic acid metabolic process linoleic acid metabolic process lipid metabolic process unsaturated fatty acid biosynthetic process | endoplasmic reticulum membrane; membrane; plasma membrane | linoleoyl-CoA desaturase activity oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water stearoyl-CoA 9-desaturase activity | Homo sapiens | Alternative splicing Electron transport Endoplasmic reticulum Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism Membrane Oxidoreductase Reference proteome Transmembrane Transmembrane helix Transport | MGKGGNQGEG | MGKGGNQGEGAAEREVSVPTFSWEEIQKHNLRTDRWLVIDRKVYNITKWSIQHPGGQRVIGHYAGEDATDAFRAFHPDLEFVGKFLKPLLIGELAPEEPSQDHGKNSKITEDFRALRKTAEDMNLFKTNHVFFLLLLAHIIALESIAWFTVFYFGNGWIPTLITAFVLATSQAQAGWLQHDYGHLSVYRKPKWNHLVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDVNMLHVFVLGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGAL... | alpha-linolenic acid metabolic process linoleic acid metabolic process lipid metabolic process unsaturated fatty acid biosynthetic process endoplasmic reticulum membrane; membrane; plasma membrane linoleoyl-CoA desaturase activity oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resu... |
arginine metabolic process citrulline metabolic process negative regulation of apoptotic process positive regulation of nitric oxide biosynthetic process | extracellular exosome; mitochondrion | amino acid binding dimethylargininase activity | Homo sapiens | Cytoplasm Direct protein sequencing Hydrolase Mitochondrion Reference proteome | MGTPGEGLGR | MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEIGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGPSHLRGLCGMGGPRTVVAGSSDAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPGLPGVPPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHS | arginine metabolic process citrulline metabolic process negative regulation of apoptotic process positive regulation of nitric oxide biosynthetic process extracellular exosome; mitochondrion amino acid binding dimethylargininase activity Homo sapiens Cytoplasm Direct protein sequencing Hydrolase Mitochondrion Reference... |
blood coagulation erythrocyte differentiation integrin-mediated signaling pathway megakaryocyte development megakaryocyte differentiation negative regulation of signal transduction platelet formation | cytosol; endoplasmic reticulum; Golgi apparatus; nucleoplasm; plasma membrane | heparin binding | Homo sapiens | 3D-structure Alternative splicing Cell membrane Direct protein sequencing Endoplasmic reticulum Glycoprotein Golgi apparatus Heparin-binding Membrane Phosphoprotein Receptor Reference proteome Signal Transmembrane Transmembrane helix | MAVFLQLLPL | MAVFLQLLPLLLSRAQGNPGASLDGRPGDRVNLSCGGVSHPIRWVWAPSFPACKGLSKGRRPILWASSSGTPTVPPLQPFVGRLRSLDSGIRRLELLLSAGDSGTFFCKGRHEDESRTVLHVLGDRTYCKAPGPTHGSVYPQLLIPLLGAGLVLGLGALGLVWWLHRRLPPQPIRPLPRFAPLVKTEPQRPVKEEEPKIPGDLDQEPSLLYADLDHLALSRPRRLSTADPADASTIYAVVV | blood coagulation erythrocyte differentiation integrin-mediated signaling pathway megakaryocyte development megakaryocyte differentiation negative regulation of signal transduction platelet formation cytosol; endoplasmic reticulum; Golgi apparatus; nucleoplasm; plasma membrane heparin binding Homo sapiens 3D-structure ... |
acetylcholine receptor signaling pathway | external side of plasma membrane; extracellular region; filopodium; plasma membrane; protein-containing complex; synapse | acetylcholine receptor inhibitor activity identical protein binding | Homo sapiens | 3D-structure Cell membrane Cell projection Disulfide bond Glycoprotein GPI-anchor Lipoprotein Membrane Reference proteome Signal | MKPQFVGILL | MKPQFVGILLSSLLGAALGNRMRCYNCGGSPSSSCKEAVTTCGEGRPQPGLEQIKLPGNPPVTLIHQHPACVAAHHCNQVETESVGDVTYPAHRDCYLGDLCNSAVASHVAPAGILAAAATALTCLLPGLWSG | acetylcholine receptor signaling pathway external side of plasma membrane; extracellular region; filopodium; plasma membrane; protein-containing complex; synapse acetylcholine receptor inhibitor activity identical protein binding Homo sapiens 3D-structure Cell membrane Cell projection Disulfide bond Glycoprotein GPI-an... |
monoacylglycerol catabolic process phosphatidylserine catabolic process prostaglandin catabolic process | membrane | acylglycerol lipase activity phospholipase activity | Homo sapiens | Alternative splicing Direct protein sequencing Disease variant Hereditary spastic paraplegia Hydrolase Lipid metabolism Membrane Neurodegeneration Reference proteome Transmembrane Transmembrane helix | MAKLLSCVLG | MAKLLSCVLGPRLYKIYRERDSERAPASVPETPTAVTAPHSSSWDTYYQPRALEKHADSILALASVFWSISYYSSPFAFFYLYRKGYLSLSKVVPFSHYAGTLLLLLAGVACLRGIGRWTNPQYRQFITILEATHRNQSSENKRQLANYNFDFRSWPVDFHWEEPSSRKESRGGPSRRGVALLRPEPLHRGTADTLLNRVKKLPCQITSYLVAHTLGRRMLYPGSVYLLQKALMPVLLQGQARLVEECNGRRAKLLACDGNEIDTMFVDRRGTAEPQGQKLVICCEGNAGFYEVGCVSTPLEAGYSVLGWNHPGFAGSTG... | monoacylglycerol catabolic process phosphatidylserine catabolic process prostaglandin catabolic process membrane acylglycerol lipase activity phospholipase activity Homo sapiens Alternative splicing Direct protein sequencing Disease variant Hereditary spastic paraplegia Hydrolase Lipid metabolism Membrane Neurodegenera... |
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | endoplasmic reticulum; endoplasmic reticulum lumen | protein-disulfide reductase (glutathione) activity protein-disulfide reductase activity | Homo sapiens | 3D-structure Direct protein sequencing Disulfide bond Endoplasmic reticulum Oxidoreductase Redox-active center Reference proteome Signal | METRPRLGAT | METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVIIHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDPSGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway endoplasmic reticulum; endoplasmic reticulum lumen protein-disulfide reductase (glutathione) activity protein-disulfide reductase activity Homo sapiens 3D-structure Direct protein sequencing Disulfide bond Endoplasmic reti... |
modification of synaptic structure modulation of chemical synaptic transmission signaling | cholinergic synapse; glutamatergic synapse; neuromuscular junction; plasma membrane; postsynaptic density; postsynaptic specialization | amyloid-beta binding molecular adaptor activity | Homo sapiens | Cell membrane Membrane Phosphoprotein Reference proteome Synapse | MRGYHGDRGS | MRGYHGDRGSHPRPARFADQQHMDVGPAARAPYLLGSREAFSTEPRFCAPRAGLGHISPEGPLSLSEGPSVGPEGGPAGAGVGGGSSTFPRMYPGQGPFDTCEDCVGHPQGKGAPRLPPTLLDQFEKQLPVQQDGFHTLPYQRGPAGAGPGPAPGTGTAPEPRSESPSRIRHLVHSVQKLFAKSHSLEAPGKRDYNGPKAEGRGGSGGDSYPGPGSGGPHTSHHHHHHHHHHHHQSRHGKRSKSKDRKGDGRHQAKSTGWWSSDDNLDSDSGFLAGGRPPGEPGGPFCLEGPDGSYRDLSFKGRSGGSEGRCLACTGMSM... | modification of synaptic structure modulation of chemical synaptic transmission signaling cholinergic synapse; glutamatergic synapse; neuromuscular junction; plasma membrane; postsynaptic density; postsynaptic specialization amyloid-beta binding molecular adaptor activity Homo sapiens Cell membrane Membrane Phosphoprot... |
mRNA processing mRNA pseudouridine synthesis positive regulation of mitochondrial translation tRNA processing | mitochondrial matrix; mitochondrion; ribonucleoprotein granule | pseudouridine synthase activity RNA binding | Homo sapiens | Alternative splicing Isomerase Mitochondrion mRNA processing Reference proteome Transit peptide tRNA processing | MGSAGLSRLH | MGSAGLSRLHGLFAVYKPPGLKWKHLRDTVELQLLKGLNARKPPAPKQRVRFLLGPMEGSEEKELTLTATSVPSFINHPLVCGPAFAHLKVGVGHRLDAQASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLVEKTTYDHVTREKLDRILAVIQGSHQKALVMYSNLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKLVHEIGLELKTTAVCTQVRRTRDGFFTLDSALLRTQWDLTNIQDAIRAATPQVAAELEKSLSPGLDTKQLPSPGWSWDSQGPS... | mRNA processing mRNA pseudouridine synthesis positive regulation of mitochondrial translation tRNA processing mitochondrial matrix; mitochondrion; ribonucleoprotein granule pseudouridine synthase activity RNA binding Homo sapiens Alternative splicing Isomerase Mitochondrion mRNA processing Reference proteome Transit pe... |
fibroblast proliferation mRNA processing positive regulation of transcription by RNA polymerase II regulation of G1/S transition of mitotic cell cycle RNA splicing | cytoplasm; cytosol; nucleoplasm; nucleus | histone acetyltransferase binding | Homo sapiens | Activator Alternative splicing Cytoplasm mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MEETMKLATM | MEETMKLATMEDTVEYCLFLIPDESRDSDKHKEILQKYIERIITRFAPMLVPYIWQNQPFNLKYKPGKGGVPAHMFGVTKFGDNIEDEWFIVYVIKQITKEFPELVARIEDNDGEFLLIEAADFLPKWLDPENSTNRVFFCHGELCIIPAPRKSGAESWLPTTPPTIPQALNIITAHSEKILASESIRAAVNRRIRGYPEKIQASLHRAHCFLPAGIVAVLKQRPRLVAAAVQAFYLRDPIDLRACRVFKTFLPETRIMTSVTFTKCLYAQLVQQRFVPDRRSGYRLPPPSDPQYRAHELGMKLAHGFEILCSKCSPHFS... | fibroblast proliferation mRNA processing positive regulation of transcription by RNA polymerase II regulation of G1/S transition of mitotic cell cycle RNA splicing cytoplasm; cytosol; nucleoplasm; nucleus histone acetyltransferase binding Homo sapiens Activator Alternative splicing Cytoplasm mRNA processing mRNA splici... |
lactate transport monocarboxylic acid transport | apical plasma membrane; basolateral plasma membrane; membrane; plasma membrane | lactate transmembrane transporter activity monocarboxylic acid transmembrane transporter activity symporter activity | Homo sapiens | Cell membrane Membrane Reference proteome Symport Transmembrane Transmembrane helix Transport | MGAGGPRRGE | MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVP... | lactate transport monocarboxylic acid transport apical plasma membrane; basolateral plasma membrane; membrane; plasma membrane lactate transmembrane transporter activity monocarboxylic acid transmembrane transporter activity symporter activity Homo sapiens Cell membrane Membrane Reference proteome Symport Transmembrane... |
cerebellar Purkinje cell differentiation immune response in nasopharyngeal-associated lymphoid tissue microtubule cytoskeleton organization mucociliary clearance protein polyglutamylation regulation of blastocyst development sperm axoneme assembly | ciliary basal body; cilium; cytoplasm; extracellular region; microtubule; motile cilium | ATP binding metal ion binding tubulin binding tubulin-glutamic acid ligase activity | Homo sapiens | Alternative splicing ATP-binding Cell projection Cilium Cytoplasm Cytoskeleton Flagellum Ligase Magnesium Metal-binding Microtubule Nucleotide-binding Reference proteome | MAGKVKWVTD | MAGKVKWVTDIEKSVLINNFEKRGWVQVTENEDWNFYWMSVQTIRNVFSVEAGYRLSDDQIVNHFPNHYELTRKDLMVKNIKRYRKELEKEGSPLAEKDENGKYLYLDFVPVTYMLPADYNLFVEEFRKSPSSTWIMKPCGKAQGKGIFLINKLSQIKKWSRDSKTSSFVSQSNKEAYVISLYINNPLLIGGRKFDLRLYVLVSTYRPLRCYMYKLGFCRFCTVKYTPSTSELDNMFVHLTNVAIQKHGEDYNHIHGGKWTVSNLRLYLESTRGKEVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKL... | cerebellar Purkinje cell differentiation immune response in nasopharyngeal-associated lymphoid tissue microtubule cytoskeleton organization mucociliary clearance protein polyglutamylation regulation of blastocyst development sperm axoneme assembly ciliary basal body; cilium; cytoplasm; extracellular region; microtubule... |
defense response to bacterium negative regulation of calcium ion import negative regulation of flagellated sperm motility negative regulation of peptidase activity | acrosomal vesicle; cell surface; extracellular space; protein-containing complex; sperm plasma membrane | serine-type endopeptidase inhibitor activity | Homo sapiens | Alternative splicing Antimicrobial Disulfide bond Protease inhibitor Reference proteome Secreted Serine protease inhibitor Signal | MGSSGLLSLL | MGSSGLLSLLVLFVLLANVQGPGLTDWLFPRRCPKIREECEFQERDVCTKDRQCQDNKKCCVFSCGKKCLDLKQDVCEMPKETGPCLAYFLHWWYDKKDNTCSMFVYGGCQGNNNNFQSKANCLNTCKNKRFP | defense response to bacterium negative regulation of calcium ion import negative regulation of flagellated sperm motility negative regulation of peptidase activity acrosomal vesicle; cell surface; extracellular space; protein-containing complex; sperm plasma membrane serine-type endopeptidase inhibitor activity Homo sa... |
embryonic organ development gastrulation in utero embryonic development mitotic G2 DNA damage checkpoint signaling mRNA splicing, via spliceosome positive regulation of cell population proliferation | catalytic step 2 spliceosome; nuclear speck; nucleoplasm; nucleus; post-mRNA release spliceosomal complex; Prp19 complex; U2-type catalytic step 2 spliceosome | RNA binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Coiled coil Isopeptide bond mRNA processing mRNA splicing Nucleus Reference proteome Spliceosome Ubl conjugation | MAAIAASEVL | MAAIAASEVLVDSAEEGSLAAAAELAAQKREQRLRKFRELHLMRNEARKLNHQEVVEEDKRLKLPANWEAKKARLEWELKEEEKKKECAARGEDYEKVKLLEISAEDAERWERKKKRKNPDLGFSDYAAAQLRQYHRLTKQIKPDMETYERLREKHGEEFFPTSNSLLHGTHVPSTEEIDRMVIDLEKQIEKRDKYSRRRPYNDDADIDYINERNAKFNKKAERFYGKYTAEIKQNLERGTAV | embryonic organ development gastrulation in utero embryonic development mitotic G2 DNA damage checkpoint signaling mRNA splicing, via spliceosome positive regulation of cell population proliferation catalytic step 2 spliceosome; nuclear speck; nucleoplasm; nucleus; post-mRNA release spliceosomal complex; Prp19 complex;... |
cell fate specification cochlea morphogenesis morphogenesis of embryonic epithelium negative regulation of canonical Wnt signaling pathway negative regulation of transcription by RNA polymerase II neural plate anterior/posterior regionalization positive regulation of DNA-templated transcription regulation of SA node ce... | chromatin; nucleoplasm; nucleus; RNA polymerase II transcription repressor complex | DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific protein homodimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Developmental protein Disease variant DNA-binding Nucleus Reference proteome Repressor Transcription Transcription regulation | MAEKRRGSPC | MAEKRRGSPCSMLSLKAHAFSVEALIGAEKQQQLQKKRRKLGAEEAAGAVDDGGCSRGGGAGEKGSSEGDEGAALPPPAGATSGPARSGADLERGAAGGCEDGFQQGASPLASPGGSPKGSPARSLARPGTPLPSPQAPRVDLQGAELWKRFHEIGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRVHVIRKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQQITRLKID... | cell fate specification cochlea morphogenesis morphogenesis of embryonic epithelium negative regulation of canonical Wnt signaling pathway negative regulation of transcription by RNA polymerase II neural plate anterior/posterior regionalization positive regulation of DNA-templated transcription regulation of SA node ce... |
adaptive immune response astrocyte differentiation brain development cardioblast differentiation CD8-positive, alpha-beta T cell differentiation involved in immune response cell differentiation involved in embryonic placenta development cerebral cortex neuron differentiation cerebral cortex regionalization chromatin re... | chromatin; nucleoplasm | chromatin DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Activator Adaptive immunity Alternative splicing Chromosomal rearrangement Developmental protein Differentiation DNA-binding Gastrulation Immunity Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MQLGEQLLVS | MQLGEQLLVSSVNLPGAHFYPLESARGGSGGSAGHLPSAAPSPQKLDLDKASKKFSGSLSCEAVSGEPAAASAGAPAAMLSDTDAGDAFASAAAVAKPGPPDGRKGSPCGEEELPSAAAAAAAAAAAAAATARYSMDSLSSERYYLQSPGPQGSELAAPCSLFPYQAAAGAPHGPVYPAPNGARYPYGSMLPPGGFPAAVCPPGRAQFGPGAGAGSGAGGSSGGGGGPGTYQYSQGAPLYGPYPGAAAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNPTAHYNVFVEVV... | adaptive immune response astrocyte differentiation brain development cardioblast differentiation CD8-positive, alpha-beta T cell differentiation involved in immune response cell differentiation involved in embryonic placenta development cerebral cortex neuron differentiation cerebral cortex regionalization chromatin re... |
cellular defense response signal transduction | cell surface; plasma membrane | signaling receptor activity transmembrane signaling receptor activity | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Membrane Receptor Reference proteome Signal Transmembrane Transmembrane helix | MAWRALHPLL | MAWRALHPLLLLLLLFPGSQAQSKAQVLQSVAGQTLTVRCQYPPTGSLYEKKGWCKEASALVCIRLVTSSKPRTMAWTSRFTIWDDPDAGFFTVTMTDLREEDSGHYWCRIYRPSDNSVSKSVRFYLVVSPASASTQTSWTPRDLVSSQTQTQSCVPPTAGARQAPESPSTIPVPSQPQNSTLRPGPAAPIALVPVFCGLLVAKSLVLSALLVWWGDIWWKTMMELRSLDTQKATCHLQQVTDLPWTSVSSPVEREILYHTVARTKISDDDDEHTL | cellular defense response signal transduction cell surface; plasma membrane signaling receptor activity transmembrane signaling receptor activity Homo sapiens 3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Membrane Receptor Reference proteome Signal Transmembrane Trans... |
anatomical structure morphogenesis cell fate specification heart looping mesoderm development mesodermal cell fate specification negative regulation of DNA-binding transcription factor activity negative regulation of neuron maturation negative regulation of neuron projection development negative regulation of transcrip... | chromatin; nucleus | DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding sequence-specific double-stranded DNA binding | Homo sapiens | Alternative splicing Developmental protein DNA-binding Dwarfism Nucleus Reference proteome Transcription Transcription regulation | MYHPRELYPS | MYHPRELYPSLGAGYRLGPAQPGADSSFPPALAEGYRYPELDTPKLDCFLSGMEAAPRTLAAHPPLPLLPPAMGTEPAPSAPEALHSLPGVSLSLENRELWKEFSSVGTEMIITKAGRRMFPACRVSVTGLDPEARYLFLLDVIPVDGARYRWQGRRWEPSGKAEPRLPDRVYIHPDSPATGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRAAQLCSQHWGGMASFRFPETTFISVTAYQNPQITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPAATEAYGSGDTPGGPCDSTLGGDIR... | anatomical structure morphogenesis cell fate specification heart looping mesoderm development mesodermal cell fate specification negative regulation of DNA-binding transcription factor activity negative regulation of neuron maturation negative regulation of neuron projection development negative regulation of transcrip... |
animal organ morphogenesis cell fate commitment cilium assembly endocrine pancreas development epithelial cell development liver development mesenchymal stem cell migration negative regulation of transforming growth factor beta receptor signaling pathway peripheral nervous system neuron development positive regulation ... | actin cytoskeleton; chromatin; nucleoplasm; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Activator DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MKAAYTAYRC | MKAAYTAYRCLTKDLEGCAMNPELTMESLGTLHGPAGGGSGGGGGGGGGGGGGGPGHEQELLASPSPHHAGRGAAGSLRGPPPPPTAHQELGTAAAAAAAASRSAMVTSMASILDGGDYRPELSIPLHHAMSMSCDSSPPGMGMSNTYTTLTPLQPLPPISTVSDKFHHPHPHHHPHHHHHHHHQRLSGNVSGSFTLMRDERGLPAMNNLYSPYKEMPGMSQSLSPLAATPLGNGLGGLHNAQQSLPNYGPPGHDKMLSPNFDAHHTAMLTRGEQHLSRGLGTPPAAMMSHLNGLHHPGHTQSHGPVLAPSRERPPSSSS... | animal organ morphogenesis cell fate commitment cilium assembly endocrine pancreas development epithelial cell development liver development mesenchymal stem cell migration negative regulation of transforming growth factor beta receptor signaling pathway peripheral nervous system neuron development positive regulation ... |
cytoskeleton organization folic acid-containing compound metabolic process histidine catabolic process to glutamate and formamide histidine catabolic process to glutamate and formate | centriole; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; Golgi apparatus; Golgi membrane; plasma membrane; smooth endoplasmic reticulum membrane | folic acid binding formimidoyltetrahydrofolate cyclodeaminase activity glutamate formimidoyltransferase activity microtubule binding | Homo sapiens | Alternative splicing Cytoplasm Cytoskeleton Disease variant Folate-binding Golgi apparatus Histidine metabolism Lyase Multifunctional enzyme Phosphoprotein Reference proteome Transferase | MSQLVECVPN | MSQLVECVPNFSEGKNQEVIDAISGAITQTPGCVLLDVDAGPSTNRTVYTFVGPPECVVEGALNAARVASRLIDMSRHQGEHPRMGALDVCPFIPVRGVSVDECVLCAQAFGQRLAEELDVPVYLYGEAARMDSRRTLPAIRAGEYEALPKKLQQADWAPDFGPSSFVPSWGATATGARKFLIAFNINLLGTKEQAHRIALNLREQGRGKDQPGRLKKVQGIGWYLDEKNLAQVSTNLLDFEVTALHTVYEETCREAQELSLPVVGSQLVGLVPLKALLDAAAFYCEKENLFILEEEQRIRLVVSRLGLDSLCPFSPKER... | cytoskeleton organization folic acid-containing compound metabolic process histidine catabolic process to glutamate and formamide histidine catabolic process to glutamate and formate centriole; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; Golgi ... |
aorta development aorta smooth muscle tissue morphogenesis elastic fiber assembly negative regulation of vascular associated smooth muscle cell proliferation positive regulation of aortic smooth muscle cell differentiation positive regulation of collagen fibril organization positive regulation of smooth muscle cell-mat... | basement membrane; collagen-containing extracellular matrix; elastic fiber; extracellular exosome; extracellular matrix; extracellular region; extracellular vesicle; microfibril | calcium ion binding extracellular matrix structural constituent heparin binding protein homodimerization activity | Homo sapiens | 3D-structure Basement membrane Calcium Direct protein sequencing Disease variant Disulfide bond EGF-like domain Extracellular matrix Glycoprotein Reference proteome Repeat Secreted Signal | MLPCASCLPG | MLPCASCLPGSLLLWALLLLLLGSASPQDSEEPDSYTECTDGYEWDPDSQHCRDVNECLTIPEACKGEMKCINHYGGYLCLPRSAAVINDLHGEGPPPPVPPAQHPNPCPPGYEPDDQDSCVDVDECAQALHDCRPSQDCHNLPGSYQCTCPDGYRKIGPECVDIDECRYRYCQHRCVNLPGSFRCQCEPGFQLGPNNRSCVDVNECDMGAPCEQRCFNSYGTFLCRCHQGYELHRDGFSCSDIDECSYSSYLCQYRCINEPGRFSCHCPQGYQLLATRLCQDIDECESGAHQCSEAQTCVNFHGGYRCVDTNRCVEPYI... | aorta development aorta smooth muscle tissue morphogenesis elastic fiber assembly negative regulation of vascular associated smooth muscle cell proliferation positive regulation of aortic smooth muscle cell differentiation positive regulation of collagen fibril organization positive regulation of smooth muscle cell-mat... |
axon guidance nervous system development neuron projection development neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of cell growth positive regulation of synaptic transmission | axon initial segment; cytoplasm; dendrite; endoplasmic reticulum; extracellular region; extracellular space; glutamatergic synapse; Golgi apparatus; synaptic cleft | signaling receptor binding | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Disease variant Endoplasmic reticulum Epilepsy Glycoprotein Golgi apparatus Leucine-rich repeat Reference proteome Repeat Secreted Signal Synapse | MESERSKRMG | MESERSKRMGNACIPLKRIAYFLCLLSALLLTEGKKPAKPKCPAVCTCTKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSSKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIETQLYVIVAQLFGGSHIYKRDSFANKFIK... | axon guidance nervous system development neuron projection development neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of cell growth positive regulation of synaptic transmission axon initial segment; cytoplasm; dendrite; endoplasmic reticulum; extracellular region; ex... |
adaptive immune response angiogenesis defense response to Gram-negative bacterium innate immune response mucosal immune response negative regulation of adaptive immune memory response negative regulation of angiogenesis negative regulation of CD4-positive, alpha-beta T cell costimulation negative regulation of T cell r... | extracellular region; plasma membrane; side of membrane | activating MHC class I receptor activity kinase binding MHC class I protein complex binding MHC class I receptor activity MHC class Ib receptor activity signaling receptor binding | Homo sapiens | 3D-structure Adaptive immunity Alternative splicing Angiogenesis Cell membrane Disulfide bond Glycoprotein GPI-anchor Immunity Immunoglobulin domain Innate immunity Lipoprotein Membrane Receptor Reference proteome Secreted Signal | MLLEPGRGCC | MLLEPGRGCCALAILLAIVDIQSGGCINITSSASQEGTRLNLICTVWHKKEEAEGFVVFLCKDRSGDCSPETSLKQLRLKRDPGIDGVGEISSQLMFTISQVTPLHSGTYQCCARSQKSGIRLQGHFFSILFTETGNYTVTGLKQRQHLEFSHNEGTLSSGFLQEKVWVMLVTSLVALQAL | adaptive immune response angiogenesis defense response to Gram-negative bacterium innate immune response mucosal immune response negative regulation of adaptive immune memory response negative regulation of angiogenesis negative regulation of CD4-positive, alpha-beta T cell costimulation negative regulation of T cell r... |
female gamete generation | endoplasmic reticulum lumen; extracellular space | cytokine activity growth factor activity | Homo sapiens | Cytokine Disease variant Disulfide bond Glycoprotein Growth factor Phosphoprotein Premature ovarian failure Pyrrolidone carboxylic acid Reference proteome Secreted Signal | MVLLSILRIL | MVLLSILRILFLCELVLFMEHRAQMAEGGQSSIALLAEAPTLPLIEELLEESPGEQPRKPRLLGHSLRYMLELYRRSADSHGHPRENRTIGATMVRLVKPLTNVARPHRGTWHIQILGFPLRPNRGLYQLVRATVVYRHHLQLTRFNLSCHVEPWVQKNPTNHFPSSEGDSSKPSLMSNAWKEMDITQLVQQRFWNNKGHRILRLRFMCQQQKDSGGLELWHGTSSLDIAFLLLYFNDTHKSIRKAKFLPRGMEEFMERESLLRRTRQADGISAEVTASSSKHSGPENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYC... | female gamete generation endoplasmic reticulum lumen; extracellular space cytokine activity growth factor activity Homo sapiens Cytokine Disease variant Disulfide bond Glycoprotein Growth factor Phosphoprotein Premature ovarian failure Pyrrolidone carboxylic acid Reference proteome Secreted Signal MVLLSILRIL MVLLSILRIL... |
activation of phospholipase C activity adenylate cyclase-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway immune response positive regulation of cytosolic calcium ion concentration regulation of metabolic process | cytoplasm; mitochondrion; plasma membrane | G protein-coupled receptor activity lipid binding sphingosine-1-phosphate receptor activity | Homo sapiens | 3D-structure Cell membrane G-protein coupled receptor Glycoprotein Lipoprotein Membrane Palmitate Receptor Reference proteome Transducer Transmembrane Transmembrane helix | MNATGTPVAP | MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLS... | activation of phospholipase C activity adenylate cyclase-activating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway immune response positive regulation of cytosolic calcium ion concentration regulation of metabolic process cytoplasm; mitochondrion; plasma membrane G protein-cou... |
blood vessel maturation canonical Wnt signaling pathway embryo implantation embryonic forelimb morphogenesis extracellular matrix organization negative regulation of cell migration negative regulation of metalloendopeptidase activity positive regulation of canonical Wnt signaling pathway regulation of angiogenesis regu... | extracellular region; membrane; plasma membrane; side of membrane; Wnt signalosome | coreceptor activity endopeptidase inhibitor activity metalloendopeptidase inhibitor activity serine-type endopeptidase inhibitor activity Wnt-protein binding | Homo sapiens | Cell membrane Disulfide bond Glycoprotein GPI-anchor Lipoprotein Membrane Protease inhibitor Reference proteome Repeat Serine protease inhibitor Signal Tumor suppressor Wnt signaling pathway | MATVRASLRG | MATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQIFSSKSESRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGLGCCELAIALECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCCSYAGHHTNCREYCQAIFRTDSSPGPSQIKAVENYCASISPQLIHCVNNYTQSYPMRNPTDSLYCCDRAEDHACQNACKRILMSKKTEMEIVDGLIEGCKTQPLPQDPLWQCFLESSQSVHPGVTVHPPPSTGLDGAKLHCCSKANTSTCRELCTKLYSMSWGNTQSWQ... | blood vessel maturation canonical Wnt signaling pathway embryo implantation embryonic forelimb morphogenesis extracellular matrix organization negative regulation of cell migration negative regulation of metalloendopeptidase activity positive regulation of canonical Wnt signaling pathway regulation of angiogenesis regu... |
chromatin remodeling DNA methylation-dependent heterochromatin formation embryonic organ development heart development in utero embryonic development negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription regulation... | chromatin; cytoplasm; heterochromatin; nucleoplasm; nucleus; NuRD complex; protein-containing complex | chromatin binding DNA binding methyl-CpG binding | Homo sapiens | 3D-structure Alternative splicing Chromosome Coiled coil DNA-binding Isopeptide bond Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Ubl conjugation | MERKRWECPA | MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMSKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLNAFDIAEELVKTMDLPKGLQGVGPGCTDETLLSAIASALHTSTMPITGQLSAAVEKNPGVWLNTTQPLCKAFMVTDEDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEDDDEEDEEEEEEEPDPDPEMEHV | chromatin remodeling DNA methylation-dependent heterochromatin formation embryonic organ development heart development in utero embryonic development negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription regulation... |
chromosome segregation DNA topological change | condensed chromosome; DNA topoisomerase III-beta-TDRD3 complex; nucleus | DNA binding DNA topoisomerase activity DNA topoisomerase type I (single strand cut, ATP-independent) activity RNA binding | Homo sapiens | 3D-structure Alternative splicing DNA-binding Isomerase Reference proteome Topoisomerase | MKTVLMVAEK | MKTVLMVAEKPSLAQSIAKILSRGSLSSHKGLNGACSVHEYTGTFAGQPVRFKMTSVCGHVMTLDFLGKYNKWDKVDPAELFSQAPTEKKEANPKLNMVKFLQVEGRGCDYIVLWLDCDKEGENICFEVLDAVLPVMNKAHGGEKTVFRARFSSITDTDICNAMACLGEPDHNEALSVDARQELDLRIGCAFTRFQTKYFQGKYGDLDSSLISFGPCQTPTLGFCVERHDKIQSFKPETYWVLQAKVNTDKDRSLLLDWDRVRVFDREIAQMFLNMTKLEKEAQVEATSRKEKAKQRPLALNTVEMLRVASSSLGMGPQH... | chromosome segregation DNA topological change condensed chromosome; DNA topoisomerase III-beta-TDRD3 complex; nucleus DNA binding DNA topoisomerase activity DNA topoisomerase type I (single strand cut, ATP-independent) activity RNA binding Homo sapiens 3D-structure Alternative splicing DNA-binding Isomerase Reference p... |
adenosine 5'-(hexahydrogen pentaphosphate) catabolic process cell-cell signaling diadenosine hexaphosphate catabolic process diadenosine pentaphosphate catabolic process diadenosine polyphosphate catabolic process diphosphoinositol polyphosphate catabolic process diphosphoinositol polyphosphate metabolic process RNA de... | cytoplasm; cytosol; nucleus | 5'-(N(7)-methyl 5'-triphosphoguanosine)- diphosphatase activity 5'-(N(7)-methylguanosine 5'-triphospho)- hydrolase activity bis(5'-adenosyl)-hexaphosphatase activity bis(5'-adenosyl)-pentaphosphatase activity diphosphoinositol-polyphosphate diphosphatase activity endopolyphosphatase activity inositol diphosphate pentak... | Homo sapiens | 3D-structure Acetylation Cytoplasm Hydrolase Magnesium Manganese Metal-binding Nucleus Reference proteome Zinc | MMKLKSNQTR | MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWFKIEDAIKVLQYHKPVQASYFETLRQGYSANNGTPVVATTYSVSAQSSMSGIR | adenosine 5'-(hexahydrogen pentaphosphate) catabolic process cell-cell signaling diadenosine hexaphosphate catabolic process diadenosine pentaphosphate catabolic process diadenosine polyphosphate catabolic process diphosphoinositol polyphosphate catabolic process diphosphoinositol polyphosphate metabolic process RNA de... |
actin filament bundle assembly actin filament polymerization cell cycle cellular response to glucocorticoid stimulus cellular response to nutrient levels cognition negative regulation of focal adhesion assembly negative regulation of G1/S transition of mitotic cell cycle negative regulation of long-term synaptic potent... | actin cytoskeleton; cytoplasm; focal adhesion; neuron projection; nuclear speck; nucleus; ruffle membrane; stress fiber; synapse | actin binding | Homo sapiens | Actin-binding Alternative splicing Cell cycle Cell junction Cell membrane Cell projection Coiled coil Cytoplasm Cytoskeleton Growth regulation Membrane Nucleus Reference proteome Stress response Synapse | MYSEIQRERA | MYSEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIATLTSEEREL | actin filament bundle assembly actin filament polymerization cell cycle cellular response to glucocorticoid stimulus cellular response to nutrient levels cognition negative regulation of focal adhesion assembly negative regulation of G1/S transition of mitotic cell cycle negative regulation of long-term synaptic potent... |
B cell chemotaxis cholesterol metabolic process lipid metabolic process negative regulation of cholesterol metabolic process negative regulation of fusion of virus membrane with host plasma membrane response to type I interferon sterol biosynthetic process | cytosol; endoplasmic reticulum membrane | C-4 methylsterol oxidase activity cholesterol 25-hydroxylase activity iron ion binding steroid hydroxylase activity | Homo sapiens | Endoplasmic reticulum Glycoprotein Iron Lipid biosynthesis Lipid metabolism Membrane Metal-binding Monooxygenase Oxidoreductase Reference proteome Steroid biosynthesis Steroid metabolism Sterol biosynthesis Sterol metabolism Transmembrane Transmembrane helix | MSCHNCSDPQ | MSCHNCSDPQVLCSSGQLFLQPLWDHLRSWEALLQSPFFPVIFSITTYVGFCLPFVVLDILCSWVPALRRYKIHPDFSPSAQQLLPCLGQTLYQHVMFVFPVTLLHWARSPALLPHEAPELLLLLHHILFCLLLFDMEFFVWHLLHHKVPWLYRTFHKVHHQNSSSFALATQYMSVWELFSLGFFDMMNVTLLGCHPLTTLTFHVVNIWLSVEDHSGYNFPWSTHRLVPFGWYGGVVHHDLHHSHFNCNFAPYFTHWDKILGTLRTASVPAR | B cell chemotaxis cholesterol metabolic process lipid metabolic process negative regulation of cholesterol metabolic process negative regulation of fusion of virus membrane with host plasma membrane response to type I interferon sterol biosynthetic process cytosol; endoplasmic reticulum membrane C-4 methylsterol oxidas... |
digestive tract morphogenesis inflammatory response lung goblet cell differentiation mucus secretion positive regulation of cell-substrate adhesion positive regulation of developmental growth positive regulation of epidermal growth factor receptor signaling pathway positive regulation of gene expression positive regula... | endoplasmic reticulum; extracellular region; extracellular space | dystroglycan binding epidermal growth factor receptor binding identical protein binding | Homo sapiens | 3D-structure Direct protein sequencing Disease variant Disulfide bond Endoplasmic reticulum Proto-oncogene Reference proteome Secreted Signal | MEKIPVSAFL | MEKIPVSAFLLLVALSYTLARDTTVKPGAKKDTKDSRPKLPQTLSRGWGDQLIWTQTYEEALYKSKTSNKPLMIIHHLDECPHSQALKKVFAENKEIQKLAEQFVLLNLVYETTDKHLSPDGQYVPRIMFVDPSLTVRADITGRYSNRLYAYEPADTALLLDNMKKALKLLKTEL | digestive tract morphogenesis inflammatory response lung goblet cell differentiation mucus secretion positive regulation of cell-substrate adhesion positive regulation of developmental growth positive regulation of epidermal growth factor receptor signaling pathway positive regulation of gene expression positive regula... |
axoneme assembly brain development cilium movement involved in cell motility determination of left/right symmetry epithelial cilium movement involved in extracellular fluid movement establishment of localization in cell flagellated sperm motility negative regulation of cell population proliferation positive regulation ... | axoneme; ciliary basal body; cilium; cytosol; extracellular region; Golgi apparatus; microtubule; motile cilium; plasma membrane; sperm flagellum | microtubule binding small GTPase binding | Homo sapiens | 3D-structure Alternative splicing Cell projection Ciliopathy Cilium Coiled coil Cytoplasm Cytoskeleton Flagellum Golgi apparatus Microtubule Primary ciliary dyskinesia Reference proteome | MAPKKKGKKG | MAPKKKGKKGKAKGTPIVDGLAPEDMSKEQVEEHVSRIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLTEMKAEGTVVMKLAQKEHRIQESVLRKDMRALKVELKEQELASEVVVKNLRLKHTEEITRMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTELHEVEERKNGQIHTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEDHLEREMAEVSGQNKRLADPLQKAREEMSEMQKQLANYERDKQILLCTKARLKVREKE... | axoneme assembly brain development cilium movement involved in cell motility determination of left/right symmetry epithelial cilium movement involved in extracellular fluid movement establishment of localization in cell flagellated sperm motility negative regulation of cell population proliferation positive regulation ... |
cell division chromosome organization DNA repair homologous chromosome segregation spermatogenesis | cytoplasm; cytosol; nucleus | cysteine-type endopeptidase inhibitor activity molecular function activator activity SH3 domain binding | Homo sapiens | 3D-structure Acetylation Cell cycle Cell division Chromosome partition Cytoplasm DNA damage DNA repair Mitosis Nucleus Phosphoprotein Proto-oncogene Reference proteome Repeat SH3-binding Ubl conjugation | MATLIYVDKE | MATLIYVDKENGEPGTRVVAKDGLKLGSGPSIKALDGRSQVSTPRFGKTFDAPPALPKATRKALGTVNRATEKSVKTKGPLKQKQPSFSAKKMTEKTVKAKSSVPASDDAYPEIEKFFPFNPLDFESFDLPEEHQIAHLPLSGVPLMILDEERELEKLFQLGPPSPVKMPSPPWESNLLQSPSSILSTLDVELPPVCCDIDI | cell division chromosome organization DNA repair homologous chromosome segregation spermatogenesis cytoplasm; cytosol; nucleus cysteine-type endopeptidase inhibitor activity molecular function activator activity SH3 domain binding Homo sapiens 3D-structure Acetylation Cell cycle Cell division Chromosome partition Cytop... |
cellular response to hydrogen peroxide cellular response to tumor necrosis factor response to lipopolysaccharide T-helper 1 type immune response | extracellular exosome; extracellular region; extracellular space | interleukin-18 binding receptor antagonist activity | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Immunoglobulin domain Reference proteome Secreted Signal | MTMRHNWTPD | MTMRHNWTPDLSPLWVLLLCAHVVTLLVRATPVSQTTTAATASVRSTKDPCPSQPPVFPAAKQCPALEVTWPEVEVPLNGTLSLSCVACSRFPNFSILYWLGNGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLEQLTPALHSTNFSCVLVDPEQVVQRHVVLAQLWAGLRATLPPTQEALPSSHSSPQQQG | cellular response to hydrogen peroxide cellular response to tumor necrosis factor response to lipopolysaccharide T-helper 1 type immune response extracellular exosome; extracellular region; extracellular space interleukin-18 binding receptor antagonist activity Homo sapiens 3D-structure Alternative splicing Direct prot... |
angiogenesis blastocyst development cardiac left ventricle formation cardiac right ventricle formation cardiac septum morphogenesis cartilage morphogenesis embryonic heart tube development embryonic heart tube formation heart development heart looping mesenchyme development mesoderm formation negative regulation of DNA... | chromatin; cytoplasm; nucleolus; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex | bHLH transcription factor binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific enzyme binding identical protein binding protein homodimerization acti... | Homo sapiens | Activator Developmental protein DNA-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MNLVGSYAHH | MNLVGSYAHHHHHHHPHPAHPMLHEPFLFGPASRCHQERPYFQSWLLSPADAAPDFPAGGPPPAAAAAATAYGPDARPGQSPGRLEALGGRLGRRKGSGPKKERRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQSGDPEAFKAELKKADGGRESKRKRELQQHEGFPPALGPVEKRIKGRTGWPQQVWALELNQ | angiogenesis blastocyst development cardiac left ventricle formation cardiac right ventricle formation cardiac septum morphogenesis cartilage morphogenesis embryonic heart tube development embryonic heart tube formation heart development heart looping mesenchyme development mesoderm formation negative regulation of DNA... |
cell differentiation regulation of T cell differentiation in thymus | endomembrane system; external side of plasma membrane; membrane; plasma membrane | GABA receptor binding | Homo sapiens | Acetylation Alternative splicing Chromosomal rearrangement Developmental protein Differentiation Glycoprotein Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix | MAAAQEADGA | MAAAQEADGARSAVVAAGGGSSGQVTSNGSIGRDPPAETQPQNPPAQPAPNAWQVIKGVLFRIFIIWAISSWFRRGPAPQDQAGPGGAPRVASRNLFPKDTLMNLHVYISEHEHFTDFNATSALFWEQHDLVYGDWTSGENSDGCYEHFAELDIPQSVQQNGSIYIHVYFTKSGFHPDPRQKALYRRLATVHMSRMINKYKRRRFQKTKNLLTGETEADPEMIKRAEDYGPVEVISHWHPNITINIVDDHTPWVKGSVPPPLDQYVKFDAVSGDYYPIIYFNDYWNLQKDYYPINESLASLPLRVSFCPLSLWRWQLYAA... | cell differentiation regulation of T cell differentiation in thymus endomembrane system; external side of plasma membrane; membrane; plasma membrane GABA receptor binding Homo sapiens Acetylation Alternative splicing Chromosomal rearrangement Developmental protein Differentiation Glycoprotein Membrane Phosphoprotein Re... |
negative regulation by host of viral genome replication positive regulation of transcription by RNA polymerase II protein autosumoylation protein sumoylation regulation of DNA-templated transcription regulation of transcription by RNA polymerase II | centrosome; chromatin; nuclear membrane; nucleoplasm; nucleus; PML body | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific identical protein binding metal ion binding protein dimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding seq... | Homo sapiens | 3D-structure DNA-binding Host-virus interaction Metal-binding Nucleus Reference proteome Transcription Transcription regulation Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger | MENKSLESSQ | MENKSLESSQTDLKLVAHPRAKSKVWKYFGFDTNAEGCILQWKKIYCRICMAQIAYSGNTSNLSYHLEKNHPEEFCEFVKSNTEQMREAFATAFSKLKPESSQQPGQDALAVKAGHGYDSKKQQELTAAVLGLICEGLYPASIVDEPTFKVLLKTADPRYELPSRKYISTKAIPEKYGAVREVILKELAEATWCGISTDMWRSENQNRAYVTLAAHFLGLGAPNCLSMGSRCLKTFEVPEENTAETITRVLYEVFIEWGISAKVFGATTNYGKDIVKACSLLDVAVHMPCLGHTFNAGIQQAFQLPKLGALLSRCRKLVE... | negative regulation by host of viral genome replication positive regulation of transcription by RNA polymerase II protein autosumoylation protein sumoylation regulation of DNA-templated transcription regulation of transcription by RNA polymerase II centrosome; chromatin; nuclear membrane; nucleoplasm; nucleus; PML body... |
Mo-molybdopterin cofactor biosynthetic process molybdopterin cofactor biosynthetic process | cytosol; molybdopterin synthase complex; nuclear speck; nucleoplasm | molybdopterin synthase activity | Homo sapiens | 3D-structure Cytoplasm Disease variant Molybdenum cofactor biosynthesis Phosphoprotein Reference proteome Transferase | MSSLEISSSC | MSSLEISSSCFSLETKLPLSPPLVEDSAFEPSRKDMDEVEEKSKDVINFTAEKLSVDEVSQLVISPLCGAISLFVGTTRNNFEGKKVISLEYEAYLPMAENEVRKICSDIRQKWPVKHIAVFHRLGLVPVSEASIIIAVSSAHRAASLEAVSYAIDTLKAKVPIWKKEIYEESSTWKGNKECFWASNS | Mo-molybdopterin cofactor biosynthetic process molybdopterin cofactor biosynthetic process cytosol; molybdopterin synthase complex; nuclear speck; nucleoplasm molybdopterin synthase activity Homo sapiens 3D-structure Cytoplasm Disease variant Molybdenum cofactor biosynthesis Phosphoprotein Reference proteome Transferas... |
monoatomic ion transport protein import into mitochondrial matrix protein insertion into mitochondrial outer membrane protein targeting to mitochondrion | cytosol; membrane; mitochondria-associated endoplasmic reticulum membrane; mitochondrial inner membrane; mitochondrial outer membrane; mitochondrial outer membrane translocase complex; mitochondrion; pore complex; TOM complex | porin activity protein transmembrane transporter activity | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Ion transport Membrane Mitochondrion Mitochondrion outer membrane Porin Protein transport Reference proteome Transmembrane Transmembrane beta strand Transport | MGNVLAASSP | MGNVLAASSPPAGPPPPPAPALVGLPPPPPSPPGFTLPPLGGSLGAGTSTSRSSERTPGAATASASGAAEDGACGCLPNPGTFEECHRKCKELFPIQMEGVKLTVNKGLSNHFQVNHTVALSTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLGPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEEGTVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSVSFGYQLDLPKANLLFKGSVDS... | monoatomic ion transport protein import into mitochondrial matrix protein insertion into mitochondrial outer membrane protein targeting to mitochondrion cytosol; membrane; mitochondria-associated endoplasmic reticulum membrane; mitochondrial inner membrane; mitochondrial outer membrane; mitochondrial outer membrane tra... |
membrane protein proteolysis proteolysis surfactant homeostasis | alveolar lamellar body; extracellular exosome; extracellular space; lysosome; multivesicular body lumen | aspartic-type endopeptidase activity endopeptidase activity peptidase activity | Homo sapiens | Aspartyl protease Direct protein sequencing Disulfide bond Glycoprotein Hydrolase Protease Reference proteome Secreted Signal Zymogen | MSPPPLLQPL | MSPPPLLQPLLLLLPLLNVEPSGATLIRIPLHRVQPGRRILNLLRGWREPAELPKLGAPSPGDKPIFVPLSNYRDVQYFGEIGLGTPPQNFTVAFDTGSSNLWVPSRRCHFFSVPCWLHHRFDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIKGASVIFGEALWEPSLVFAFAHFDGILGLGFPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPEEPDGGELVLGGSDPAHYIPPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDTGTSLITGPTEEIRALHAAIGGIPLLAGEYIILCSEI... | membrane protein proteolysis proteolysis surfactant homeostasis alveolar lamellar body; extracellular exosome; extracellular space; lysosome; multivesicular body lumen aspartic-type endopeptidase activity endopeptidase activity peptidase activity Homo sapiens Aspartyl protease Direct protein sequencing Disulfide bond G... |
peroxisome fission peroxisome organization regulation of peroxisome size signal transduction | cytosol; intracellular membrane-bounded organelle; membrane; mitochondrion; nucleoplasm; peroxisomal membrane; peroxisome; protein-containing complex | identical protein binding protein homodimerization activity | Homo sapiens | Acetylation Alternative splicing Membrane Peroxisome Peroxisome biogenesis Peroxisome biogenesis disorder Reference proteome Transmembrane Transmembrane helix | MDAWVRFSAQ | MDAWVRFSAQSQARERLCRAAQYACSLLGHALQRHGASPELQKQIRQLESHLSLGRKLLRLGNSADALESAKRAVHLSDVVLRFCITVSHLNRALYFACDNVLWAGKSGLAPRVDQEKWAQRSFRYYLFSLIMNLSRDAYEIRLLMEQESSACSRRLKGSGGGVPGGSETGGLGGPGTPGGGLPQLALKLRLQVLLLARVLRGHPPLLLDVVRNACDLFIPLDKLGLWRCGPGIVGLCGLVSSILSILTLIYPWLRLKP | peroxisome fission peroxisome organization regulation of peroxisome size signal transduction cytosol; intracellular membrane-bounded organelle; membrane; mitochondrion; nucleoplasm; peroxisomal membrane; peroxisome; protein-containing complex identical protein binding protein homodimerization activity Homo sapiens Acet... |
apoptotic process cell cycle cell migration cellular response to organic cyclic compound cytoskeleton organization dendritic spine development intracellular signal transduction negative regulation of endothelial cell apoptotic process phosphorylation positive regulation of angiogenesis regulation of cell growth regulat... | adherens junction; cytoplasm; cytosol; focal adhesion; Golgi apparatus | ATP binding cadherin binding involved in cell-cell adhesion protein kinase activity protein serine kinase activity protein serine/threonine kinase activity | Homo sapiens | 3D-structure Alternative splicing Apoptosis ATP-binding Cell cycle Cytoplasm Kinase Methylation Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase Ubl conjugation | MFGKRKKRVE | MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSY... | apoptotic process cell cycle cell migration cellular response to organic cyclic compound cytoskeleton organization dendritic spine development intracellular signal transduction negative regulation of endothelial cell apoptotic process phosphorylation positive regulation of angiogenesis regulation of cell growth regulat... |
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