Biological Process stringlengths 7 1.01k | Cellular Component stringlengths 6 867 | Molecular Function stringlengths 11 871 | Organism stringlengths 8 73 | Keywords stringlengths 1 810 | Sequence 10 stringlengths 5 10 | Sequence stringlengths 5 1.02k | Combined stringlengths 136 3.91k |
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apoptotic process defense response to bacterium killing of cells of another organism | extracellular region | L-phenylalaine oxidase activity toxin activity | Crotalus adamanteus | Antibiotic Antimicrobial Apoptosis Cytolysis Direct protein sequencing Disulfide bond FAD Flavoprotein Glycoprotein Hemolysis Hemostasis impairing toxin Oxidoreductase Secreted Signal Toxin | MNVFFMFSLL | MNVFFMFSLLFLAALGSCAHDRNPLEECFRETDYEEFLEIAKNGLTATSNPKRVVIVGAGMAGLSAAYVLAGAGHQVTVLEASERVGGRVRTYRKKDWYANLGPMRLPTKHRIVREYIKKFDLKLNEFSQENENAWYFIKNIRKRVREVKNNPGLLEYPVKPSEEGKSAAQLYVESLRKVVEELRSTNCKYILDKYDTYSTKEYLLKEGNLSPGAVDMIGDLLNEDSGYYVSFIESLKHDDIFGYEKRFDEIVGGMDQLPTSMYEAIKEKVQVHFNARVIEIQQNDREATVTYQTSANEMSSVTADYVIVCTTSRAARRI... | apoptotic process defense response to bacterium killing of cells of another organism extracellular region L-phenylalaine oxidase activity toxin activity Crotalus adamanteus Antibiotic Antimicrobial Apoptosis Cytolysis Direct protein sequencing Disulfide bond FAD Flavoprotein Glycoprotein Hemolysis Hemostasis impairing ... |
anatomical structure morphogenesis determination of left/right symmetry embryonic limb morphogenesis embryonic organ morphogenesis heart looping heart morphogenesis positive regulation of dermatome development positive regulation of myoblast differentiation positive regulation of myoblast proliferation positive regulat... | nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding | Gallus gallus | Alternative splicing Developmental protein DNA-binding Homeobox Nucleus Reference proteome | MSCMKDPLSL | MSCMKDPLSLERLGAGNNKLCSSSPSSSSSSSSCHHQQPALAMATALAPGQARSSLEAAKHRLEVHTISDTSSPEAAEKEKSQQGKSEDAGPEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSGLNSLNNLNNLSNPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPAS... | anatomical structure morphogenesis determination of left/right symmetry embryonic limb morphogenesis embryonic organ morphogenesis heart looping heart morphogenesis positive regulation of dermatome development positive regulation of myoblast differentiation positive regulation of myoblast proliferation positive regulat... |
actin-myosin filament sliding muscle contraction muscle tissue morphogenesis skeletal muscle tissue development | cytoplasm; myosin complex | calcium ion binding | Danio rerio | Calcium Metal-binding Motor protein Muscle protein Myosin Phosphoprotein Reference proteome Repeat | MAPKKAKRRA | MAPKKAKRRAAGGEGSSNVFSMFEQSQIQEYKEAFTIIDQNRDGIISKDDLRDVLASMGQLNVKNEELEAMIKEASGPINFTVFLTMFGEKLKGADPEDVIVSAFKVLDPEGTGSIKKEFLEELLTTQCDRFTAEEMKNLWAAFPPDVAGNVDYKNICYVITHGEEKEE | actin-myosin filament sliding muscle contraction muscle tissue morphogenesis skeletal muscle tissue development cytoplasm; myosin complex calcium ion binding Danio rerio Calcium Metal-binding Motor protein Muscle protein Myosin Phosphoprotein Reference proteome Repeat MAPKKAKRRA MAPKKAKRRAAGGEGSSNVFSMFEQSQIQEYKEAFTIID... |
cellular response to amino acid stimulus cellular response to ethanol cellular response to zinc ion central nervous system development chloride transmembrane transport monoatomic ion transport neuropeptide signaling pathway regulation of neuron differentiation response to amino acid synaptic transmission, glycinergic | chloride channel complex; dendrite; membrane; neuron projection; perikaryon; plasma membrane; postsynaptic membrane; synapse | extracellularly glycine-gated chloride channel activity extracellularly glycine-gated ion channel activity glycine binding ligand-gated monoatomic ion channel activity transmembrane signaling receptor activity transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential zi... | Danio rerio | 3D-structure Cell membrane Cell projection Chloride Chloride channel Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Membrane Metal-binding Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport Zinc | MFALGIYLWE | MFALGIYLWETIVFFSLAASQQAAARKAASPMPPSEFLDKLMGKVSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRISKNGNVLYSIRITLVLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWDEKGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFS... | cellular response to amino acid stimulus cellular response to ethanol cellular response to zinc ion central nervous system development chloride transmembrane transport monoatomic ion transport neuropeptide signaling pathway regulation of neuron differentiation response to amino acid synaptic transmission, glycinergic c... |
angiogenesis artery morphogenesis blood vessel development definitive hemopoiesis embryonic heart tube development embryonic hemopoiesis endocardium formation endocardium morphogenesis erythrocyte differentiation heart development heart morphogenesis hemangioblast cell differentiation hematopoietic stem cell differenti... | nucleus | DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific protein dimerization activity RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding | Danio rerio | Alternative splicing Angiogenesis Developmental protein Differentiation DNA-binding Nucleus Reference proteome Transcription Transcription regulation | MMEKLKSEQF | MMEKLKSEQFPLSPSAEGCASPPRGDGDARGKQEGTTAETGEHRLPEELNGVAKETAHHATELKKEVAVIELSRRGGSADIKGRELKAELSHKVQTTELCRPPIPLPLPPRDPLSDTRMVQLSPPAFPLPARAMLYSNMTTPLATINSGFAGDAEQYGMYPSNRVKRRPAPYEVEINDGSQPKIVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLNDQDDMVGGEAPARANRDSRDATLVRDDLLQEMLSPNSSCGSLLDGDASPESFTEDQDSSVESRPSARGLHHSSLPLDG... | angiogenesis artery morphogenesis blood vessel development definitive hemopoiesis embryonic heart tube development embryonic hemopoiesis endocardium formation endocardium morphogenesis erythrocyte differentiation heart development heart morphogenesis hemangioblast cell differentiation hematopoietic stem cell differenti... |
proteolysis | extracellular region | metal ion binding metalloendopeptidase activity toxin activity | Bothrops jararaca | 3D-structure Calcium Cell adhesion impairing toxin Direct protein sequencing Disulfide bond Glycoprotein Hemorrhagic toxin Hemostasis impairing toxin Hydrolase Metal-binding Metalloprotease Platelet aggregation inhibiting toxin Protease Pyrrolidone carboxylic acid Secreted Signal Toxin Zinc Zymogen | MIEVLLVTIC | MIEVLLVTICLAAFPYQGSSIILESGNVNDYEVVYPRKVTALPKGAVQPKYEDAMQYEFKVNGEPVVLHLEKNKGLFSKDYSETHYSPDGREITTYPAVEDHCYYHGRIENDADSTASISACNGLKGHFKLQRETYFIEPLKLSNSEAHAVFKYENVEKEDEAPKMCGVTQNWKSYEPIKKASQLVVTAEQQKYNPFRYVELFIVVDQGMVTKNNGDLDKIKARMYELANIVNEILRYLYMHAALVGLEIWSNGDKITVKPDVDYTLNSFAEWRKTDLLTRKKHDNAQLLTAIDFNGPTIGYAYIGSMCHPKRSVAIVED... | proteolysis extracellular region metal ion binding metalloendopeptidase activity toxin activity Bothrops jararaca 3D-structure Calcium Cell adhesion impairing toxin Direct protein sequencing Disulfide bond Glycoprotein Hemorrhagic toxin Hemostasis impairing toxin Hydrolase Metal-binding Metalloprotease Platelet aggreg... |
cellular detoxification cellular response to oxidative stress cellular response to starvation filamentous growth filamentous growth of a population of unicellular organisms filamentous growth of a population of unicellular organisms in response to starvation | mitochondrion; plasma membrane | D-arabinono-1,4-lactone oxidase activity FAD binding L-galactonolactone oxidase activity L-gulonolactone oxidase activity | Candida albicans | FAD Flavoprotein Oxidoreductase Reference proteome Virulence | MTDIPESLKP | MTDIPESLKPFVTKKVIHSTWAGTFLCKPQAIFQPRNVEEIQELIKQARLHGKTIMTVGSGHSPSDLTMTTEWLCNLDKFNHVLLEEPYYAPKSPTDDTPEIKFVDLTVEAGTRIFELNEYLKRNNLAIQNLGSISDQSIAGLISTGTHGSTQYHGLVSQQVVSVKFLNSAGELITCSSVDKPEYFRAILLSLGKIGIITHVTLRTCPKYTIKSKQEIINFETLLNNWDNLWLESEFIRIWWFPYTNKCVLWRANKSTDPLSDPRPSWYGTKLGRFFYESLLWVSVHLFPRLTPFVEKFVFGQQYGEVETLGKGDIAVQN... | cellular detoxification cellular response to oxidative stress cellular response to starvation filamentous growth filamentous growth of a population of unicellular organisms filamentous growth of a population of unicellular organisms in response to starvation mitochondrion; plasma membrane D-arabinono-1,4-lactone oxidas... |
ergosterol biosynthetic process | endoplasmic reticulum lumen; endoplasmic reticulum membrane | C-5 sterol desaturase activity delta7-sterol 5(6)-desaturase activity iron ion binding | Candida albicans | Endoplasmic reticulum Iron Lipid biosynthesis Lipid metabolism Membrane Oxidoreductase Steroid biosynthesis Steroid metabolism Sterol biosynthesis Sterol metabolism Transmembrane Transmembrane helix | MDIVLEICDY | MDIVLEICDYYLFDKVYADVFPKDGAVHEFLKPAIQSFSQIDFPSLPNLDSFDTNSTLISSNNFNISNVNPATIPSYLFSKIASYQDKSEIYGLAPKFFPATDFINTSFLARSNIFRETLSLFIITTIFGWLLYFIVAYLSYVFVFDKKIFNHPRYLKNQMSLEIKRATTAIPVMVLLTIPFFLLELNGYSFLYLDINECTGGYKAILWQIPKFILFTDCGIYFLHRWLHWPSVYKVLHKPHHKWIVCTPFASHAFHPVDGFFQSLPYHLYPLLFPLHKVLYLFLFTFVNFWTVMIHDGSYWSNDPVVNGTACHTVHHLY... | ergosterol biosynthetic process endoplasmic reticulum lumen; endoplasmic reticulum membrane C-5 sterol desaturase activity delta7-sterol 5(6)-desaturase activity iron ion binding Candida albicans Endoplasmic reticulum Iron Lipid biosynthesis Lipid metabolism Membrane Oxidoreductase Steroid biosynthesis Steroid metaboli... |
CAMKK-AMPK signaling cascade carbohydrate metabolic process establishment of mitotic spindle orientation fungal-type cell wall assembly invasive growth in response to glucose limitation negative regulation of TORC1 signaling negative regulation of translation phosphorylation positive regulation of ascus development pos... | cellular bud neck septin ring; nuclear envelope lumen; nuclear membrane; nucleotide-activated protein kinase complex; vacuolar membrane | AMP-activated protein kinase activity ATP binding guanyl-nucleotide exchange factor activity identical protein binding protein serine kinase activity | Candida tropicalis | ATP-binding Carbohydrate metabolism Kinase Membrane Nucleotide-binding Nucleus Phosphoprotein Serine/threonine-protein kinase Transferase | MSEQNQGQPD | MSEQNQGQPDQQHSGDHQHHHHHHHHHHHSQQPAQPIPIDPNVNPANRIGRYQIIKTLGEGSFGKVKLAQHVGTGQKVALKIINRKTLAKSDMQGRVEREISYLRLLRHPHIIKLYDVIKSKDEIIMVIEFAGKELFDYIVQRGKMPEDEARRFFQQIIAAVEYCHRHKIVHRDLKPENLLLDDQLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVISGKLYAGPEVDVWSSGVILYVMLCGRLPFDDEFIPALFKKISNGVYTLPNYLSPGAKHLLTRMLVVNPLNRITIHEIMEDEWFKQDMPDYLLPPDLSKIK... | CAMKK-AMPK signaling cascade carbohydrate metabolic process establishment of mitotic spindle orientation fungal-type cell wall assembly invasive growth in response to glucose limitation negative regulation of TORC1 signaling negative regulation of translation phosphorylation positive regulation of ascus development pos... |
polysaccharide catabolic process | extracellular region | inulinase activity | Aspergillus ficuum | 3D-structure Carbohydrate metabolism Glycoprotein Glycosidase Hydrolase Polysaccharide degradation Secreted Signal | MLNPKVAYMV | MLNPKVAYMVWMTCLGLTLPSQAQSNDYRPSYHFTPDQYWMNEPNGLIKIGSTWHLFFQHNPTANVWGNICWGHATSTDLMHWAHKPTAIADENGVEAFTGTAYYDPNNTSGLGDSANPPYLAWFTGYTTSSQTQDQRLAFSVDNGATWTKFQGNPIISTSQEAPHDITGGLESRDPKVFFHRQSGNWIMVLAHGGQDKLSFWTSADTINWTWQSDLKSTSINGLSSDITGWEVPDMFELPVEGTEETTWVVMMTPAEGSPAGGNGVLAITGSFDGKSFTADPVDASTMWLDNGRDFDGALSWVNVPASDGRRIIAAVMN... | polysaccharide catabolic process extracellular region inulinase activity Aspergillus ficuum3D-structure Carbohydrate metabolism Glycoprotein Glycosidase Hydrolase Polysaccharide degradation Secreted Signal MLNPKVAYMV MLNPKVAYMVWMTCLGLTLPSQAQSNDYRPSYHFTPDQYWMNEPNGLIKIGSTWHLFFQHNPTANVWGNICWGHATSTDLMHWAHKPTAIADENGVEAFTGTA... |
cell division chromosome segregation meiosis I meiotic centromeric cohesion protection in anaphase I meiotic spindle assembly checkpoint signaling mitotic spindle assembly checkpoint signaling phosphorylation protein localization to kinetochore | cytosol; kinetochore; nucleus | ATP binding protein serine kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity | Schizosaccharomyces pombe | ATP-binding Cell cycle Cell division Kinase Mitosis Nucleotide-binding Reference proteome Serine/threonine-protein kinase Transferase | MSKRNPPVTN | MSKRNPPVTNIADLVSDSSLDEDSLSFLEELQDPELYFKNDTFSSKSSHSDGTVTGDTLRRQSSGATALERLVSHPRTKNFDLQGNGGQNSALKEVNTPAYQSMHHFEHLITPLPSTNASHSEVSLSAGVNDLNSNSEHDLLPKSVNKTPGSLSISRRRRIGRIGLGPPKRAEYTLTDPSKTSDTKNSTEADEDIEMKSREVSPASNSVAATTLKPLQLHNTPLQTSQEHPKPSFHPSQFESSFSPRVQFDHDVERRASELHSRPVTVFQEPQRSASQPYESHALSPKVAPLFDNSQATPIPKRQQDVVTVANLQFIKLG... | cell division chromosome segregation meiosis I meiotic centromeric cohesion protection in anaphase I meiotic spindle assembly checkpoint signaling mitotic spindle assembly checkpoint signaling phosphorylation protein localization to kinetochore cytosol; kinetochore; nucleus ATP binding protein serine kinase activity pr... |
cap-dependent translational initiation formation of cytoplasmic translation initiation complex translational initiation | cytoplasmic stress granule; cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiation factor 3 complex, eIF3e; eukaryotic translation initiation factor 3 complex, eIF3m | mRNA cap binding translation initiation factor activity | Schizosaccharomyces pombe | Cytoplasm Initiation factor Protein biosynthesis Reference proteome RNA-binding | MATGFKLPEL | MATGFKLPELAPVKSAWGPPETEQIGGDIPYAPFSKGDRLGKIADWSVDQPKDGREQRGRQGAFAGRFRDQYQTYGYGASSIFGYQHSEDESSFSVIDRGSVNRTRTSARNGGTLLKVRGRGQNVQRGGRGGRYGSSGGRGAGDTVVSRSSGAGGARGRRFGWKDYDKHQRLRNASVTVGDDWQLLDEVEFSHLSKLNLAAAAPVTVDSYGYIYPYDKSFDKIHVKSEKPLQALDRVHYNPTTTEDPVIQKLALNSDANIFITDSILSLLMCSTRSVYPWDIVITHQSGKLFFDKREGGPFDYLTVNENAYDSPMDADNR... | cap-dependent translational initiation formation of cytoplasmic translation initiation complex translational initiation cytoplasmic stress granule; cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiation f... |
CENP-A containing chromatin assembly chromatin remodeling | CENP-A recruiting complex; chromosome, centromeric region; cytoplasm; kinetochore; nucleus | H3-H4 histone complex chaperone activity histone binding | Schizosaccharomyces pombe | 3D-structure Centromere Chromatin regulator Chromosome Cytoplasm Kinetochore Nucleus Phosphoprotein Reference proteome Repeat WD repeat | MSEEVVQDAP | MSEEVVQDAPLENNELNAEIDLQKTIQEEYKLWKQNVPFLYDLVITHALEWPSLTIQWLPDKKTIPGTDYSIQRLILGTHTSGNDQNYLQIASVQLPNFDEDTTEFTPSTIRRAQATGSYTIEISQKIPHDGDVNRARYMPQKPEIIATMGEGGNAYIFDTTCHDALTTGEALPQAVLKGHTAEGFGLCWNPNLPGNLATGAEDQVICLWDVQTQSFTSSETKVISPIAKYHRHTDIVNDVQFHPQHEALLASVSDDCTLQIHDTRLNPEEEAPKVIQAHSKAINAVAINPFNDYLLATASADKTVALWDLRNPYQRLHT... | CENP-A containing chromatin assembly chromatin remodeling CENP-A recruiting complex; chromosome, centromeric region; cytoplasm; kinetochore; nucleus H3-H4 histone complex chaperone activity histone binding Schizosaccharomyces pombe 3D-structure Centromere Chromatin regulator Chromosome Cytoplasm Kinetochore Nucleus Ph... |
chromatin organization constitutive heterochromatin formation DNA repair DNA replication DNA replication-dependent chromatin assembly nucleosome organization transcription elongation by RNA polymerase II transcription elongation-coupled chromatin remodeling | euchromatin; FACT complex; nucleus | H2A-H2B histone complex chaperone activity histone chaperone activity nucleosome binding | Schizosaccharomyces pombe | 3D-structure Chromosome Coiled coil DNA damage DNA repair DNA replication Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MAEYEIDEIT | MAEYEIDEITFHKRLGILLTSWKNEEDGKTLFQDCDSILVTVGAHDDTNPYQKSTALHTWLLGYEFPSTLILLEKHRITILTSVNKANMLTKLAETKGAAADVNILKRTKDAEENKKLFEKIIEYIRATNKKVGVFPKDKTQGKFINEWDSIFEPVKSEFNLVDASLGLAKCLAIKDEQELANIKGASRVSVAVMSKYFVDELSTYIDQGKKITHSKFSDQMESLIDNEAFFQTKSLKLGDIDLDQLEWCYTPIIQSGGSYDLKPSAITDDRNLHGDVVLCSLGFRYKSYCSNVGRTYLFDPDSEQQKNYSFLVALQKKL... | chromatin organization constitutive heterochromatin formation DNA repair DNA replication DNA replication-dependent chromatin assembly nucleosome organization transcription elongation by RNA polymerase II transcription elongation-coupled chromatin remodeling euchromatin; FACT complex; nucleus H2A-H2B histone complex cha... |
cellular response to nitrogen starvation macroautophagy membrane fusion protein transport vacuole organization | autophagosome; autophagosome membrane; cytoplasm; cytoplasmic vesicle; cytosol; fungal-type vacuole; fungal-type vacuole membrane; nucleus; phagophore assembly site | phosphatidylethanolamine binding | Schizosaccharomyces pombe | 3D-structure Autophagy Cytoplasmic vesicle Lipoprotein Membrane Protein transport Reference proteome Transport Ubl conjugation pathway Vacuole | MRSQFKDDFS | MRSQFKDDFSFEKRKTESQRIREKYPDRIPVICEKVDKSDIAAIDKKKYLVPSDLTVGQFVYVIRKRIKLSPEKAIFIFIDEILPPTAALMSTIYEEHKSEDGFLYITYSGENTFGTVFPF | cellular response to nitrogen starvation macroautophagy membrane fusion protein transport vacuole organization autophagosome; autophagosome membrane; cytoplasm; cytoplasmic vesicle; cytosol; fungal-type vacuole; fungal-type vacuole membrane; nucleus; phagophore assembly site phosphatidylethanolamine binding Schizosacch... |
meiotic cell cycle pericentric heterochromatin formation regulatory ncRNA-mediated heterochromatin formation silent mating-type cassette heterochromatin formation subtelomeric heterochromatin formation | chromosome, telomeric region; nucleolus; nucleus; pericentric heterochromatin | protein-macromolecule adaptor activity | Schizosaccharomyces pombe | 3D-structure Cell cycle Meiosis Nucleus Reference proteome | MDFKSRKYKI | MDFKSRKYKIKKHPKDCKLHAKKYRGTLNSKGKNDNDCLIMCMRCRKVKGIDSYSKTQWSKTFTFVRGRTVSVSDPKVICRTCQPKQHDSIWCTACQQTKGINEFSKAQRHVLDPRCQICVHSQRNDGDDNLESDKFVDPFIGDDSDLDDDIYIHDKQTINSEYADDVSDNTDEERTESKGQQESNSAEEYDDDDSDEDRMEEIFQQFKKEKQIV | meiotic cell cycle pericentric heterochromatin formation regulatory ncRNA-mediated heterochromatin formation silent mating-type cassette heterochromatin formation subtelomeric heterochromatin formation chromosome, telomeric region; nucleolus; nucleus; pericentric heterochromatin protein-macromolecule adaptor activity S... |
protein urmylation tRNA thio-modification tRNA wobble position uridine thiolation tRNA wobble uridine modification | cytosol; cytosolic tRNA wobble base thiouridylase complex | ATP binding nucleotidyltransferase activity tRNA binding tRNA-uracil-34 sulfurtransferase activity | Schizosaccharomyces pombe | Cytoplasm Reference proteome RNA-binding Transferase tRNA processing tRNA-binding | MSNKLCQLCN | MSNKLCQLCNERRPALVRPKTGQKICKECFYYVFETEIHNVIIENKLFVRGERVGIGASGGKDSTVLAYVMKLLNERYDYGLELYLISVDEGIRGYRDDSLDTVKRNQQQYGLPMKIVSYADLYDGWTMDNVVARIGTKNNCTYCGVFRRQALDRAALSLDIHHLVTGHNADDIAETILMNLLRGDVARLPRSTEITTQSDSSPTKRSKPFKYSYEKEIVLYAHYKKLDYFSTECTYSPEAFRGTARAMIKQLENIRPSSILDIIYSGESMQLASSVQEQLPQQTTCERCGFISSNRICKACMLLEGLNKGITGLGLGSD... | protein urmylation tRNA thio-modification tRNA wobble position uridine thiolation tRNA wobble uridine modification cytosol; cytosolic tRNA wobble base thiouridylase complex ATP binding nucleotidyltransferase activity tRNA binding tRNA-uracil-34 sulfurtransferase activity Schizosaccharomyces pombe Cytoplasm Reference p... |
mRNA splicing, via spliceosome spliceosomal tri-snRNP complex assembly | cytosol; nucleus; post-mRNA release spliceosomal complex; Prp19 complex; spliceosomal complex; U2-type catalytic step 2 spliceosome; U4/U6 x U5 tri-snRNP complex; U5 snRNP | GTP binding GTPase activity U5 snRNA binding | Schizosaccharomyces pombe | 3D-structure Cytoplasm GTP-binding mRNA processing mRNA splicing Nucleotide-binding Nucleus Reference proteome | MMEEDLYDEF | MMEEDLYDEFGNYIGPENEEDEEELFPQAPSPTIAQVPSFEEVIPDEELEDVERAEEMALSHLEPQNAVVLHEDKQYYPSAEEVYGSNVDIMVQEQDTQPLSQPIIEPIRHKRIAIETTNVPDTVYKKEFLFGLLTGTDDVRSFIVAGHLHHGKSALLDLLVYYTHPDTKPPKRRSLRYTDTHYLERERVMSIKSTPLTLAVSDMKGKTFAFQCIDTPGHVDFVDEVAAPMAISDGVVLVVDVIEGVMINTTRIIKHAILHDMPIVLVLNKVDRLILELRLPPNDAYHKLRHVIDEVNDNICQISKDLKYRVSPELGNVC... | mRNA splicing, via spliceosome spliceosomal tri-snRNP complex assembly cytosol; nucleus; post-mRNA release spliceosomal complex; Prp19 complex; spliceosomal complex; U2-type catalytic step 2 spliceosome; U4/U6 x U5 tri-snRNP complex; U5 snRNP GTP binding GTPase activity U5 snRNA binding Schizosaccharomyces pombe 3D-st... |
cell division division septum assembly positive regulation of mitotic actomyosin contractile ring contraction positive regulation of protein phosphorylation positive regulation of septation initiation signaling protein localization signal transduction | cell division site; cytoplasm; cytosol; medial cortex; mitotic spindle pole body; new mitotic spindle pole body; nucleus; old mitotic spindle pole body; Sid2-Mob1 complex | protein kinase activator activity | Schizosaccharomyces pombe | Cell cycle Cell division Cytoplasm Cytoskeleton Mitosis Reference proteome Septation | MFGFSNKTAK | MFGFSNKTAKTFRVRKTEAGTKHYQLRQYAEATLGSGSLMEAVKLPKGEDLNEWIAMNTMDFYTQINMLYGTITEFCTAASCPQMNAGPSYEYYWQDDKIYTKPTRMSAPDYINNLLDWTQEKLDDKKLFPTEIGVEFPKNFRKVIQQIFRRLFRIYAHIYCSHFHVMVAMELESYLNTSFKHFVFFCREFGLMDNKEYAPMQDLVDSMV | cell division division septum assembly positive regulation of mitotic actomyosin contractile ring contraction positive regulation of protein phosphorylation positive regulation of septation initiation signaling protein localization signal transduction cell division site; cytoplasm; cytosol; medial cortex; mitotic spind... |
positive regulation of L-arginine import across plasma membrane positive regulation of TORC1 signaling small GTPase mediated signal transduction | cytosol; extrinsic component of cytoplasmic side of plasma membrane; nucleus; plasma membrane | GDP binding GTP binding GTPase activity protein serine/threonine kinase activator activity | Schizosaccharomyces pombe | Cell membrane GTP-binding Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Reference proteome | MAPIKSRRIA | MAPIKSRRIAVLGSRSVGKSSLTVQYVENHFVESYYPTIENTFSKNIKYKGQEFATEIIDTAGQDEYSILNSKHSIGIHGYVLVYSITSKSSFEMVKIVRDKILNHTGTEWVPIVVVGNKSDLHMQRAVTAEEGKALANEWKCAWTEASARHNENVARAFELIISEIEKQANPSPPGDGKGCVIA | positive regulation of L-arginine import across plasma membrane positive regulation of TORC1 signaling small GTPase mediated signal transduction cytosol; extrinsic component of cytoplasmic side of plasma membrane; nucleus; plasma membrane GDP binding GTP binding GTPase activity protein serine/threonine kinase activator... |
cell division chromatin looping homologous chromosome pairing at meiosis mitotic sister chromatid cohesion regulation of cohesin loading | nuclear chromosome; nucleus; Wpl/Pds5 cohesin loading/unloading complex | ATP hydrolysis activity ATP-dependent protein binding cohesin unloader activity DNA binding | Schizosaccharomyces pombe | Cell cycle Cell division Chromosome Mitosis Nucleus Reference proteome | MKRGKCKEKD | MKRGKCKEKDNGLKRISSESEVWNFLDVTVSELNKQKRSPGQTVSKRLHKKQRVVSNPDLSLPSSPVKQILRNGLQNSKYGSHKTGLERSASCSSIDASANHSSTTYREQRSYLMEEGLDTQPIVPREVSSGRELDSTNHTIGTERAFLIEEDVSEDDEIQMKSIHELRFAGEQQRIVDEIEYLVDGVTFSGNSSASRYLSLIGIAEKMFDNSFRLCLKSIRDVFLRIFEEIDPKDTLHTFLQIYIFATMANEMDCMSSLLDAYSNNVKLLLQTAITLEPQVPVSILAKSLPKSVKGAVQEFVIKAELTFSFSNESLASS... | cell division chromatin looping homologous chromosome pairing at meiosis mitotic sister chromatid cohesion regulation of cohesin loading nuclear chromosome; nucleus; Wpl/Pds5 cohesin loading/unloading complex ATP hydrolysis activity ATP-dependent protein binding cohesin unloader activity DNA binding Schizosaccharomyces... |
cell division mitotic nuclear pore complex disassembly NLS-bearing protein import into nucleus protein import into nucleus regulation of mitotic nuclear envelope disassembly | cytoplasm; cytosol; mitotic spindle midzone; nuclear envelope; nuclear periphery; nuclear pore; nucleolus; nucleoplasm; nucleus | GTP binding nuclear import signal receptor activity nuclear localization sequence binding | Schizosaccharomyces pombe | Cell cycle Cell division Cytoplasm Mitosis Nucleus Protein transport Reference proteome Repeat Transport | MESRYLSDRR | MESRYLSDRRSRFKSKGVFKADELRRQREEQQIEIRKQKREESLNKRRNLNAVLQNDIDVEEEADQSQVQMEQQMKDEFPKLTADVMSDDIELQLGAVTKFRKYLSKETHPPIDQVIACGVVDRFVQFLESEHHLLQFEAAWALTNIASGTTDQTRIVVDSGAVPRFIQLLSSPEKDVREQVVWALGNIAGDSSACRDYVLGNGVLQPLLNILQSSASDVSMLRNATWTLSNLCRGKNPPPNWSTISVAVPILAKLLYSEDVEIIVDACWAISYLSDGPNEKIGAILDVGCAPRLVELLSSPSVNIQTPALRSVGNIVTG... | cell division mitotic nuclear pore complex disassembly NLS-bearing protein import into nucleus protein import into nucleus regulation of mitotic nuclear envelope disassembly cytoplasm; cytosol; mitotic spindle midzone; nuclear envelope; nuclear periphery; nuclear pore; nucleolus; nucleoplasm; nucleus GTP binding nuclea... |
DNA recombination double-strand break repair via nonhomologous end joining replication fork processing stalled replication fork localization to nuclear periphery telomere maintenance | chromosome, subtelomeric region; chromosome, telomeric repeat region; heterochromatin; Ku70:Ku80 complex; nucleus; pericentric heterochromatin; site of double-strand break | 3'-5' DNA helicase activity ATP binding ATP hydrolysis activity damaged DNA binding telomeric DNA binding | Schizosaccharomyces pombe | ATP-binding Chromosome DNA damage DNA recombination DNA repair DNA-binding Helicase Hydrolase Nucleotide-binding Nucleus Reference proteome Telomere | MENDEQIDET | MENDEQIDETENFAIGKYAILFVIEVSPSMLDPVDEFTPSSLQMALICAYQLAAQRVITNPSDIMGVLLYGTESSTGRFANQMMLLDIDPPDAERIKSLQSFEKDFQFSKEKFKPCSCQVSLSSVLYHCSVIFTTKAENFEKRLFLITDNDHPAWDATERDIILQRAKDLRDLDIQVHPVFLDPPTHSFRINIFYSDFLYIVYGRQDVSNLVNRGQAQLQHMLNMITALQKPKRAHFHLKMDLGNDVRIGVEAFILLKRLESAKTNWVYAKGERFAVAVPQSKQVSFATKKELKKDEIRRSYSYGGSSVVFGSDELNKVR... | DNA recombination double-strand break repair via nonhomologous end joining replication fork processing stalled replication fork localization to nuclear periphery telomere maintenance chromosome, subtelomeric region; chromosome, telomeric repeat region; heterochromatin; Ku70:Ku80 complex; nucleus; pericentric heterochro... |
mRNA processing mRNA pseudouridine synthesis snRNA pseudouridine synthesis tRNA pseudouridine synthesis | nucleus | metal ion binding pseudouridine synthase activity RNA binding snRNA pseudouridine synthase activity | Schizosaccharomyces pombe | Isomerase Metal-binding mRNA processing Nucleus Phosphoprotein Reference proteome tRNA processing Zinc | MGRGGKRTWY | MGRGGKRTWYNGDRREAKRNRPNSIYNGEGRPENLVVGEKKPKRKVACLVGYCGSGYHGMQLNPPSKTIEGDLFDAFVKAGAVSSYNADDPKKVALARAARTDKGVHAAGNVISLKLIMEDEKLIEKVNEHLPPSIRLWDVIRTINSFNPRTYCESRIYEYMVPTYAFVPPKPSSILGNCIMKNSPMPAEPINKENINQLSRSLFYEEGKEFWDDYDIAAKEILSLYEQDPEGFVNPYSKRGAAALANSENNKGSEAGVSAKTNPDMDSDSSAIVNEFLKPDSVEDESAGSKIDPSYRLERALKHIEVLKLKNYRISADR... | mRNA processing mRNA pseudouridine synthesis snRNA pseudouridine synthesis tRNA pseudouridine synthesis nucleus metal ion binding pseudouridine synthase activity RNA binding snRNA pseudouridine synthase activity Schizosaccharomyces pombe Isomerase Metal-binding mRNA processing Nucleus Phosphoprotein Reference proteome... |
chromatin remodeling DNA damage response regulation of transcription by RNA polymerase II transcription initiation-coupled chromatin remodeling | chromatin; Ino80 complex; nucleus; SWI/SNF complex; transcription factor TFIID complex; transcription factor TFIIF complex | histone binding RNA polymerase II general transcription initiation factor activity | Schizosaccharomyces pombe | Chromatin regulator DNA damage Nucleus Reference proteome Transcription Transcription regulation | MTTVKRTVRL | MTTVKRTVRLITDQNVLPGGEAAVLNDQSFPVREWSIKLVCLNPQGEETDASFVDRVTYKLHPTFQNPTRTIRKPPFQIKEQGWGEFEMEIIIYYADKGGEHRFLHYLHFQQEHYHEDIELNINATRPGLLKALTATGEVPGYSDEGEEARKDKRKNESEVGAGKKKAKAKPVDMDKLAEGLQKLQEDDLLQVVQMVNENKTPDMYVRNDIEGGEFHIDLYTLPDNLLLLLYSFCAKRVTM | chromatin remodeling DNA damage response regulation of transcription by RNA polymerase II transcription initiation-coupled chromatin remodeling chromatin; Ino80 complex; nucleus; SWI/SNF complex; transcription factor TFIID complex; transcription factor TFIIF complex histone binding RNA polymerase II general transcripti... |
mitotic recombination-dependent replication fork processing proteasome-mediated ubiquitin-dependent protein catabolic process stalled replication fork localization to nuclear periphery | cytosol; nucleus; proteasome regulatory particle, base subcomplex; proteasome regulatory particle, lid subcomplex | K48-linked polyubiquitin modification-dependent protein binding ubiquitin binding | Schizosaccharomyces pombe | 3D-structure Nucleus Proteasome Reference proteome Ubl conjugation pathway | MVLEATMILI | MVLEATMILIDNSEWMINGDYIPTRFEAQKDTVHMIFNQKINDNPENMCGLMTIGDNSPQVLSTLTRDYGKFLSAMHDLPVRGNAKFGDGIQIAQLALKHRENKIQRQRIVAFVGSPIVEDEKNLIRLAKRMKKNNVAIDIIHIGELQNESALQHFIDAANSSDSCHLVSIPPSPQLLSDLVNQSPIGQGVVASQNQFEYGVDPNLDVELALALELSMAEERARQEVAAQKSSEETEDKKMQE | mitotic recombination-dependent replication fork processing proteasome-mediated ubiquitin-dependent protein catabolic process stalled replication fork localization to nuclear periphery cytosol; nucleus; proteasome regulatory particle, base subcomplex; proteasome regulatory particle, lid subcomplex K48-linked polyubiqui... |
DNA repair DNA repair-dependent chromatin remodeling negative regulation of DNA-templated transcription positive regulation of heterochromatin formation positive regulation of transcription by RNA polymerase II | NuA4 histone acetyltransferase complex; nucleus; pericentric heterochromatin; site of double-strand break | histone H3K4 acetyltransferase activity histone H4K16 acetyltransferase activity metal ion binding peptide 2-hydroxyisobutyryltransferase activity peptide butyryltransferase activity peptide crotonyltransferase activity transcription coregulator activity | Schizosaccharomyces pombe | Acetylation Activator Chromatin regulator Chromosome DNA damage DNA repair Metal-binding Nucleus Reference proteome Transcription Transcription regulation Transferase Zinc Zinc-finger | MSNDVDDESK | MSNDVDDESKIETKSYEAKDIVYKSKVFAFKDGEYRKAEILMIQKRTRGVVYYVHYNDYNKRLDEWITIDNIDLSKGIEYPPPEKPKKAHGKGKSSKRPKAVDRRRSITAPSKTEPSTPSTEKPEPSTPSGESDHGSNAGNESLPLLEEDHKPESLSKEQEVERLRFSGSMVQNPHEIARIRNINKICIGDHEIEPWYFSPYPKEFSEVDIVYICSFCFCYYGSERQFQRHREKCTLQHPPGNEIYRDDYISFFEIDGRKQRTWCRNICLLSKLFLDHKMLYYDVDPFLFYCMCRRDEYGCHLVGYFSKEKESSENYNLA... | DNA repair DNA repair-dependent chromatin remodeling negative regulation of DNA-templated transcription positive regulation of heterochromatin formation positive regulation of transcription by RNA polymerase II NuA4 histone acetyltransferase complex; nucleus; pericentric heterochromatin; site of double-strand break his... |
DNA repair DNA strand elongation involved in DNA replication DNA-templated DNA replication mitotic DNA replication leading strand elongation UV-damage excision repair | chromatin; Ctf18 RFC-like complex; cytosol; DNA replication factor C complex; Elg1 RFC-like complex; nucleus; Rad17 RFC-like complex | ATP binding ATP hydrolysis activity DNA binding DNA clamp unloader activity | Schizosaccharomyces pombe | ATP-binding Cell cycle Direct protein sequencing DNA replication DNA-binding Nucleotide-binding Nucleus Reference proteome | MSNAVSSSVF | MSNAVSSSVFGEKNNSVAYELPWVEKYRPIVLDDIVGNEETIDRLKVIAKEGNMPHLVISGMPGIGKTTSILCLAHALLGPAYKEGVLELNASDERGIDVVRNRIKAFAQKKVILPPGRHKIIILDEADSMTAGAQQALRRTMEIYSNTTRFALACNQSNKIIEPIQSRCAILRYSRLTDQQVLQRLLNICKAEKVNYTDDGLAALIMTAEGDMRQAVNNLQSTVAGFGLVNGENVFRVADQPSPVAIHAMLTACQSGNIDVALEKLQGIWDLGFSAVDIVTNMFRVVKTMDSIPEFSRLEMLKEIGQTHMIILEGVQTL... | DNA repair DNA strand elongation involved in DNA replication DNA-templated DNA replication mitotic DNA replication leading strand elongation UV-damage excision repair chromatin; Ctf18 RFC-like complex; cytosol; DNA replication factor C complex; Elg1 RFC-like complex; nucleus; Rad17 RFC-like complex ATP binding ATP hydr... |
linear element assembly non-recombinational interstrand cross-link repair protein sumoylation reciprocal meiotic recombination replication fork processing stalled replication fork localization to nuclear periphery telomere maintenance | nucleus; site of double-strand break | SUMO ligase activity zinc ion binding | Schizosaccharomyces pombe | Metal-binding Nucleus Phosphoprotein Reference proteome Transferase Ubl conjugation pathway Zinc Zinc-finger | MNQANFLQEL | MNQANFLQELPNVLKRLETGLIIPQLKDILRVFGLRLSGTKAELITRIKQLIERIAIENNTTSWEALKKAIDGDVTSAVCILKYNTYQIYSAAAPIAPPSSASGNRSYSRPFAPVVHSRIRFRKSPFYDILEQFNAPFVVPACVGTRNTISFSFHVTPPALSKLLNDPKQYRVYLFSTPSETIGFGNCLMEFPTPQMELRINNQVAHANYRRLKGKPGTTNPADITDLVSKYAGPPGNNVVIYYMNSTKSYSVVVCFVKVYTIENLVDQIKSRKAESKEKIIERIKNDNQDADIIATSTDISLKCPLSFSRISLPVRSVF... | linear element assembly non-recombinational interstrand cross-link repair protein sumoylation reciprocal meiotic recombination replication fork processing stalled replication fork localization to nuclear periphery telomere maintenance nucleus; site of double-strand break SUMO ligase activity zinc ion binding Schizosacc... |
ergosterol biosynthetic process sterol biosynthetic process | endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; membrane | C-5 sterol desaturase activity delta7-sterol 5(6)-desaturase activity iron ion binding | Schizosaccharomyces pombe | Endoplasmic reticulum Iron Lipid biosynthesis Lipid metabolism Membrane Oxidoreductase Reference proteome Steroid biosynthesis Steroid metabolism Sterol biosynthesis Sterol metabolism Transmembrane Transmembrane helix | MDYLLNYADQ | MDYLLNYADQYALDSIYNAVYPLARDNIVRQSISLFFLTWFGGMFLYLTFASLSYQFVFDKSLMDHPKFLKNQVFMEVLTALQNLPGMALLTVPWFLAELHGYSYLYDNISDYGLKYFLCSLPLFVMFSDFGIYWAHRFLHHRYVYPRLHKLHHKWIICTPYASHAFKSADGFLQSLPYHLFPFFFPLHKLTYLALFTFVNFWSIMIHDGKYISNNPIINGAAHHNGHHIYFNYNYGQFTTLFDRLGNSFRAPDEAWFDKDLRQNEDVLRVELMEYEAIRNEVEGDDDREYIANSAKKNH | ergosterol biosynthetic process sterol biosynthetic process endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; membrane C-5 sterol desaturase activity delta7-sterol 5(6)-desaturase activity iron ion binding Schizosaccharomyces pombe Endoplasmic reticulum Iron Lipid biosynthesis Lipid metabolism Me... |
cell division chromatin looping chromosome segregation maintenance of mitotic sister chromatid cohesion mitotic sister chromatid cohesion | chromatin; cytosol; nucleus; Scc2-Scc4 cohesin loading complex; SMC loading complex | ATP hydrolysis activity cohesin loader activity double-stranded DNA binding | Schizosaccharomyces pombe | Cell cycle Cell division Chromosome partition Mitosis Nucleus Reference proteome | MTGLNETDAR | MTGLNETDARILVTSRHLFLWPLAETYFKNAEKVLQDCGVCDSFGRLLSTGLQCLYSVLMDTKMEPRVELLTRKRICEVLLSHTVEYADVEAILNRALIIAEQHNLTEYKFSLQLLLSRVFCRTSPKAAKVLLTRCVREAEEYAKVAEIYHSNNQSNPHRWVYEFLLATLEFQNVSQVANSIHNYANHHKHQHLQLLAMILNQSLPMDEISTDSDQISILCLVTQIAQCLRKGEILLAREILPKIHSKLESETFVWPSSYIDFFIDDTSKISIKWMSINQLYLLIYLISGFCYISDSTSGRASRFLQEGLRITGDFKHQE... | cell division chromatin looping chromosome segregation maintenance of mitotic sister chromatid cohesion mitotic sister chromatid cohesion chromatin; cytosol; nucleus; Scc2-Scc4 cohesin loading complex; SMC loading complex ATP hydrolysis activity cohesin loader activity double-stranded DNA binding Schizosaccharomyces po... |
actin cytoskeleton organization Golgi to plasma membrane protein transport mitotic division septum assembly negative regulation of cell wall integrity MAPK cascade positive regulation of mitotic division septum assembly signal transduction | actin cortical patch; cell cortex of cell tip; cell division site; cell tip; cleavage furrow; cytoplasm; cytoplasmic side of plasma membrane; cytosol; Golgi apparatus; mitotic actomyosin contractile ring; mitotic actomyosin contractile ring, proximal layer | GTPase activator activity | Schizosaccharomyces pombe | Coiled coil GTPase activation Phosphoprotein Reference proteome | MLSAPSSSTT | MLSAPSSSTTPASPPTSPPNTTSSDDFAVLKEPKVEAILNSELGLAILNDRIKDYLLTCKELAGFFKKRSILEEESGKNLQKLAKSYLETFQSKHHSPQSFSASVITSMEIHEQLANHSLTLQKTLSAFSDQVIEFHKNAERKRKSIKEYAKKQENAYLEAVMQMDKSKSRFKGAETEYNRALDNKNTGDSQKKVGFFKPKSNAQLTKLEDEARLKAENAESDMHSKIENAQNVQKQLLCIHRPNYIKQFFSLQREIESSLIANYLRYTKLCESNTLLNGLTIRPQKPTPTNCGLQHALDNINANTDFVQYVLHASIKHE... | actin cytoskeleton organization Golgi to plasma membrane protein transport mitotic division septum assembly negative regulation of cell wall integrity MAPK cascade positive regulation of mitotic division septum assembly signal transduction actin cortical patch; cell cortex of cell tip; cell division site; cell tip; cle... |
ascospore-type prospore membrane formation intracellular signal transduction lipid droplet localization to prospore membrane leading edge phosphorylation | cytosol; meiotic spindle pole body; nucleolus; nucleus; prospore membrane; spindle pole body | ATP binding protein serine kinase activity protein serine/threonine kinase activity | Schizosaccharomyces pombe | ATP-binding Cytoplasm Kinase Meiosis Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase | MDLLGLKELD | MDLLGLKELDNNKLVSKAKENGVEFSDLFLLSSGYLRDRENASASVSSKNERMVLNEERQNCWTKRNDPKGLTYYQLLKPSEVEILSRPETRRKRMACQVFFLNYYISTIEYHKLRKERLEEFTACTSSLKQSKQKRLWKEHCGRERAFLRKKRTKIQCSHFDLLVKLGQGGYGSVWLAKKRNTHELLAMKMMKKSTLQQLNEVKHILNERDILTNTNSEWLVKLYYAFQDKEKVYLAMEYVPGGDFRTFLTTKGLLHENQTRFYLAEMVAAISAVHKLGYMHRDLKPENFLIDQKGHIKLSDFGLSTAIVTSNQVNRLQ... | ascospore-type prospore membrane formation intracellular signal transduction lipid droplet localization to prospore membrane leading edge phosphorylation cytosol; meiotic spindle pole body; nucleolus; nucleus; prospore membrane; spindle pole body ATP binding protein serine kinase activity protein serine/threonine kinas... |
cell redox homeostasis cellular detoxification | mitochondrion | protein-disulfide reductase activity | Schizosaccharomyces pombe | Disulfide bond Electron transport Mitochondrion Redox-active center Reference proteome Stress response Transit peptide Transport | MRGFIANSLK | MRGFIANSLKPHMRSFALRRSFTSSRILRKVNAVESFGDYNTRISADKVTVVDFYADWCGPCKYLKPFLEKLSEQNQKASFIAVNADKFSDIAQKNGVYALPTMVLFRKGQELDRIVGADVKTLSSLLAKYQE | cell redox homeostasis cellular detoxification mitochondrion protein-disulfide reductase activity Schizosaccharomyces pombe Disulfide bond Electron transport Mitochondrion Redox-active center Reference proteome Stress response Transit peptide Transport MRGFIANSLK MRGFIANSLKPHMRSFALRRSFTSSRILRKVNAVESFGDYNTRISADKVTVVDFY... |
methionine biosynthetic process phosphatidylinositol phosphate biosynthetic process sulfate assimilation | cytosol; nucleus | 3'(2'),5'-bisphosphate nucleotidase activity inositol-1,3,4-trisphosphate 1-phosphatase activity inositol-1,4-bisphosphate 1-phosphatase activity metal ion binding nucleotide binding | Schizosaccharomyces pombe | Hydrolase Magnesium Metal-binding Nucleotide-binding Reference proteome | MSFDAEKQLA | MSFDAEKQLAIAAVRRASYLTEKVFNQLIKEKSAAGALTKDDKSPVTIGDFGAQAIVISMLKDAFPNDPIVGEEDSDFLRENTQTCSRVWELVQETIQHATEYKELGQIKSAEEMMSIIDQGSYHGGRNGRMWTLDPIDGTKGFLRGAQYAICLALIENGKPVVSAIGCPNLPYDFNQPETSPKGIIMSAVRNHGCFQYSLHNEKLEPVQVHMQDVQNTKDSKFCEGVEAGHSMQGTQEEIAKYLGITRGPTKMDSQAKYASLARGDGDIYLRLPTKMTFEEKIWDHAGGSLLVEEAGGVVSDMFGKPLDFGVGRTLKNN... | methionine biosynthetic process phosphatidylinositol phosphate biosynthetic process sulfate assimilation cytosol; nucleus 3'(2'),5'-bisphosphate nucleotidase activity inositol-1,3,4-trisphosphate 1-phosphatase activity inositol-1,4-bisphosphate 1-phosphatase activity metal ion binding nucleotide binding Schizosaccharom... |
alpha-glucan catabolic process involved in ascospore release from ascus ascospore release from ascus cell division extracellular polysaccharide catabolic process involved in ascospore release from ascus fungal-type cell wall disassembly involved in conjugation with cellular fusion | ascus epiplasm; cytosol; mating projection actin fusion focus; nucleus | glucan endo-1,3-alpha-glucosidase activity | Schizosaccharomyces pombe | Cell cycle Cell division Glycosidase Hydrolase Reference proteome | MASLTTALPN | MASLTTALPNKAVVAHFMMGLTYNYAQSDFQNDIQNAISLGLDGFVLNFGNDSWMMSKLTLMYNAADALNLQFLLYLNLDMSEMSTVPASTLVTYVQTFANRGHQARINNNVVVGTFLGQDINFGQSSVNQGWQVAFKNALASAGINIFFMPTWPLDASTIYQTYPVADGFCKWNCWPYYTSSPTSDAEDLVYIQNSKATNKKYMATVSPIFYTHFTSKNYSFFSEGLWFTRWMQLIKDQPNYVQVLTWNDYGESTYIGPTNYAADFPVIGSNSHEWVDSFTHAPLSYSLPLFIQMYKQNTTGLPSNFSGISQLYVTYRV... | alpha-glucan catabolic process involved in ascospore release from ascus ascospore release from ascus cell division extracellular polysaccharide catabolic process involved in ascospore release from ascus fungal-type cell wall disassembly involved in conjugation with cellular fusion ascus epiplasm; cytosol; mating projec... |
eukaryotic translation initiation factor 3 complex assembly formation of cytoplasmic translation initiation complex translational initiation | cytoplasm; cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiation factor 3 complex, eIF3e; nucleus | translation initiation factor activity | Schizosaccharomyces pombe | Cytoplasm Initiation factor Phosphoprotein Protein biosynthesis Reference proteome Stress response | MGSELKSTSP | MGSELKSTSPLAVKYDLSQKIMQHLDRHLIFPLLEFLSLRQTHDPKELLQAKYDLLKDTNMTDYVANLWTNLHGGHTDEDMANAFAEKRRSVLQELSELEEEVQGILGVLENPDLIAALRQDKGQNLQHLQEHYNITPERIAVLYKFAQFQYNCGNYGGASDLLYHFRAFSKDPELNASATWGKFASEILTVDWDGAMEELGKLREMVDSKSFKDSAVQLRNRTWLLHWSLFPLFNHANGCDTLCDLFFYTPYLNTIQTSCPWLLRYLTVAVVTNQNNANQKPRNPRQSYQRRMRDLVRIISQENYEYSDPVTSFISALY... | eukaryotic translation initiation factor 3 complex assembly formation of cytoplasmic translation initiation complex translational initiation cytoplasm; cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiati... |
constitutive heterochromatin formation DNA repair DNA replication DNA replication-dependent chromatin assembly nucleosome organization transcription elongation-coupled chromatin remodeling | cytosol; euchromatin; FACT complex; nuclear replication fork; nucleus | DNA binding H2A-H2B histone complex chaperone activity histone binding nucleosome binding | Schizosaccharomyces pombe | Chromosome DNA damage DNA repair DNA replication Nucleus Reference proteome Transcription Transcription regulation | MAAKTVQYDN | MAAKTVQYDNIYLNLSEKPGKLRIAPSGLGWKSPSLAEPFTLPISEIRRFCWSRFARGYELKIILKSKDPVSLDGFSQEDLDDLINVIKQNFDMGIEQKEFSIKGWNWGEANFLGSELVFDVNSRPAFEIPISAVTNTNLSGKNEVALEFSTTDDKQIPSAQVDELVEMRLYVPGTTAKEDAADGEEVEQNAANLFYESLKERADIGQAAGDAIVSFSEILLLTPRGRYDIDMYETCMRLRGKTYDYKVEYSSINSLFLLPKPDEQHVVFVIGLEPPLRQGQTRYPFLVTQFVRDEDMEVDLNIEETVLKEKYADKVKAS... | constitutive heterochromatin formation DNA repair DNA replication DNA replication-dependent chromatin assembly nucleosome organization transcription elongation-coupled chromatin remodeling cytosol; euchromatin; FACT complex; nuclear replication fork; nucleus DNA binding H2A-H2B histone complex chaperone activity histon... |
attachment of mitotic spindle microtubules to kinetochore cell division cytoplasmic microtubule organization establishment or maintenance of microtubule cytoskeleton polarity meiotic centromere clustering microtubule nucleation by spindle pole body microtubule polymerization mitotic spindle assembly mitotic spindle elo... | cytoplasmic microtubule; cytoplasmic microtubule plus-end; cytosol; kinetochore; meiotic spindle; microtubule cytoskeleton; mitotic spindle; mitotic spindle microtubule; mitotic spindle pole body; nucleus; outer kinetochore; spindle pole; spindle pole body; static microtubule bundle; TACC/TOG complex | microtubule binding microtubule plus end polymerase microtubule plus-end binding | Schizosaccharomyces pombe | Cell cycle Cell division Centromere Chromosome Coiled coil Cytoplasm Cytoskeleton Kinetochore Microtubule Mitosis Phosphoprotein Reference proteome Repeat | MSQDQEEDYS | MSQDQEEDYSKLPLESRIVHKVWKVRLSAYEECSKSFSLSADGSDNCFELWNNQSELWKSVLTDSNVAAQEAGTAAFVAYCRFSDPSHLLKAREISVLSISEKCLTSPRAGTRENALEALMLLVEADSAAPVIESIIPSLSARSPKVIASNVAAIASLVEQFGAKVIPSKMIIPHISNLFGHADKNVRKEASRLTVNIYRWTGDPLKDLLFKDLRPVQTKELESLFAELPTEPPKQTRFLKSQQPTSEPNVETQVEEQPALENEESEPEPSDDQFDLVEEVDVLPNVDPNLETLMASSKWKDRKEALDKLLPVLSQPKIK... | attachment of mitotic spindle microtubules to kinetochore cell division cytoplasmic microtubule organization establishment or maintenance of microtubule cytoskeleton polarity meiotic centromere clustering microtubule nucleation by spindle pole body microtubule polymerization mitotic spindle assembly mitotic spindle elo... |
cytoplasm to vacuole transport by the NVT pathway peptide catabolic process protein catabolic process proteolysis | cytosol; fungal-type vacuole lumen; multivesicular body; nucleus; NVT complex | aminopeptidase activity epoxide hydrolase activity metalloaminopeptidase activity zinc ion binding | Schizosaccharomyces pombe | Cytoplasm Hydrolase Metal-binding Metalloprotease Nucleus Protease Reference proteome Zinc | MKLRLDPSTQ | MKLRLDPSTQSNYHDVSISKLDWHARIDFDQELLHGKVSFVIQSARVSQALSHIILDTSYLEIKNVTINDIPTPFRVDKRRGFLGSALHIVPADEIPSSKSCILTILYSTTKDCTALQFLKPEQTIGGKFPYVFSECQAIHARSFIPCQDTPSVKVPCTFKIRSKLPVIASGIPCGTANFCNGSLEYLFEQKNPIPSYLFCILSGDLASTNIGPRSSVYTEPGNLLACKYEFEHDMENFMEAAEQLTLPYCWTRYDFVILPPSFPYGGMENPNATFATPTLIAGDRSNVNVIAHELAHSWSGNLVTNESWQCFWLNEGMT... | cytoplasm to vacuole transport by the NVT pathway peptide catabolic process protein catabolic process proteolysis cytosol; fungal-type vacuole lumen; multivesicular body; nucleus; NVT complex aminopeptidase activity epoxide hydrolase activity metalloaminopeptidase activity zinc ion binding Schizosaccharomyces pombe Cy... |
cellular response to osmotic stress cellular response to oxidative stress meiotic cell cycle mitotic DNA damage checkpoint signaling negative regulation of G2/M transition of mitotic cell cycle negative regulation of induction of conjugation with cellular fusion negative regulation of protein localization to nucleus ph... | ascospore-type prospore; cytoplasm; nucleolus; nucleus | ATP binding protein serine kinase activity protein serine/threonine kinase activity | Schizosaccharomyces pombe | ATP-binding Cytoplasm Kinase Meiosis Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase | MRFKSIQQNI | MRFKSIQQNIEDEGKVNVREVNPDSYAERDHGYTAGIFSDAEENFGITQQVADSTQNPTSKPKSRHAHFHETVHENPSEYSRSKCKQPTNEKEYDKAIEALVAKAIVEEHSGQQFPVYKGLEQYTLLQKMGDGAFSNVYKAIHNRTGEKVAIKVVQRAQPNTDPRDPRKRQGVESHNILKEVQIMRRVKHPNIIQLLEFIQTPEYYYLVLELADGGELFHQIVRLTYFSEDLSRHVITQVAHAIRYLHEDCGVVHRDIKPENLLFDSIDFVPSRVRKYRAGDDPDKVDEGEFIPGVGAGTIGRIRLADFGLSKVVWDSHT... | cellular response to osmotic stress cellular response to oxidative stress meiotic cell cycle mitotic DNA damage checkpoint signaling negative regulation of G2/M transition of mitotic cell cycle negative regulation of induction of conjugation with cellular fusion negative regulation of protein localization to nucleus ph... |
cell redox homeostasis cellular detoxification of hydrogen peroxide cellular response to oxidative stress hydrogen peroxide catabolic process removal of superoxide radicals | cytoplasm; cytosol; nucleus | thioredoxin peroxidase activity thioredoxin-dependent peroxiredoxin activity | Schizosaccharomyces pombe | Antioxidant Cytoplasm Disulfide bond Nucleus Oxidoreductase Peroxidase Redox-active center Reference proteome | MDAPRRSSRL | MDAPRRSSRLAAKIANVLDSKGTIIPEAAPVMLKKPAKDESVDSTIQVGDVIPDITLPDEDGTSIRLRDITANKGLVIFAYPKASTPGCTKQGCGFRDNYPKIQASDYEVLGLSFDTSKAQKAFKDKQNFPYHLLSDPKGELIKKLGAEKPGGGKLFRSHWIFEKGTGKCIVKEIDISPLVSVDKAFAVITDSEP | cell redox homeostasis cellular detoxification of hydrogen peroxide cellular response to oxidative stress hydrogen peroxide catabolic process removal of superoxide radicals cytoplasm; cytosol; nucleus thioredoxin peroxidase activity thioredoxin-dependent peroxiredoxin activity Schizosaccharomyces pombe Antioxidant Cyt... |
DNA repair protein sumoylation proteolysis | cytosol; nucleus | double-stranded DNA binding metallopeptidase activity proteasome binding single-stranded DNA binding transition metal ion binding zinc ion binding | Schizosaccharomyces pombe | 3D-structure Cytoplasm DNA damage DNA repair Hydrolase Metal-binding Metalloprotease Nucleus Protease Reference proteome Zinc | MELKFSCRGN | MELKFSCRGNVIALSFNENDTVLDAKEKLGQEIDVSPSLIKLLYKGNLSDDSHLQDVVKNESKIMCLIRQDKDIVNQAISQLKVPDYSTNTYSLKPKKPHTTPKPASIYTFNELVVLDYPHKDRALRYLERLRDDTGIKKIMDSHRWTVPLLSEMDPAEHTRHDSKTLGLNHNQGAHIELRLRTDRYDGFRDYKTVKSTLIHELTHNVHGEHDSSFWELFRQLTKEADAADLLGKPGSYVSDRASYTPQQDNDDEDQKNHRRDLLLAAAERRKQSGSKVQKE | DNA repair protein sumoylation proteolysis cytosol; nucleus double-stranded DNA binding metallopeptidase activity proteasome binding single-stranded DNA binding transition metal ion binding zinc ion binding Schizosaccharomyces pombe 3D-structure Cytoplasm DNA damage DNA repair Hydrolase Metal-binding Metalloprotease N... |
CDP-diacylglycerol biosynthetic process phosphatidylethanolamine biosynthetic process phosphatidylserine biosynthetic process phosphatidylserine metabolic process plasma membrane organization | cytoplasm; cytoplasmic vesicle membrane; cytosol; endoplasmic reticulum membrane | CDP-diacylglycerol-serine O-phosphatidyltransferase activity | Schizosaccharomyces pombe | Cytoplasmic vesicle Endoplasmic reticulum Lipid biosynthesis Lipid metabolism Membrane Phospholipid biosynthesis Phospholipid metabolism Reference proteome Transferase Transmembrane Transmembrane helix | MVRSRVSPGL | MVRSRVSPGLKLQSDASNQSNDKENKLLAYVNDNRHFSLIRALHLADLITLMNGFCGVMSIFSSLRYCLSGQQSAFHLWNAMYFMPFALFFDFLDGKVARWRGKSSLMGQELDSLADLISFGVSPAVFAFCCGFQTFLDTVILSLFVLCGLTRLARFNVSVNSIPKDGSGKSQFFEGTPIPTTLSLVTVCGVCILKGKTHENLPWGEWCGNTPFAFHPLVVLFVLSGIAMTSKKLKVPKI | CDP-diacylglycerol biosynthetic process phosphatidylethanolamine biosynthetic process phosphatidylserine biosynthetic process phosphatidylserine metabolic process plasma membrane organization cytoplasm; cytoplasmic vesicle membrane; cytosol; endoplasmic reticulum membrane CDP-diacylglycerol-serine O-phosphatidyltransfe... |
heterochromatin boundary formation regulation of regulatory ncRNA-mediated heterochromatin formation regulation of transcription by RNA polymerase II | heterochromatin; heterochromatin island; nucleus | histone demethylase activity histone H3K36me/H3K36me2 demethylase activity metal ion binding transcription coregulator activity | Schizosaccharomyces pombe | Chromatin regulator Dioxygenase Iron Metal-binding Nucleus Oxidoreductase Reference proteome Transcription Transcription regulation | MDSWLEYDDI | MDSWLEYDDIINQDIDIPSNDLSGSGTLCVGVHSSLLENSLNSIDSFISSKEEISWCGNQSTPIATKSHLSCINPQYVNPFDTSPVSVDTEFQDTYLLDAPSFAQPHFSERQSVDKTRSRCLSRNRRRKRHPNLHKNHQRLLGMSFPQDGFRRMPAESVNFSYFRDTGFNEPTIFPSSDTQNTRQLNLSKIATLIGYDCPLALVDVVTQKQIPNKMDMESWVKYMSLEPSKRGRIYDVLSLEVSTTKLAYYVRKPNIVRDLDLVNTVWPPGSFALGEYPHVDTYCLMSAENSYTEFHIEFGGSSAYYNILDGCKIFYLIP... | heterochromatin boundary formation regulation of regulatory ncRNA-mediated heterochromatin formation regulation of transcription by RNA polymerase II heterochromatin; heterochromatin island; nucleus histone demethylase activity histone H3K36me/H3K36me2 demethylase activity metal ion binding transcription coregulator ac... |
DNA damage response protein ubiquitination ubiquitin-dependent protein catabolic process | cytoplasm; cytosol; nucleus | ATP binding ATP hydrolysis activity magnesium ion binding ubiquitin activating enzyme activity | Schizosaccharomyces pombe | 3D-structure ATP-binding Cytoplasm Ligase Nucleotide-binding Nucleus Reference proteome Ubl conjugation pathway | MSNNMNIDQT | MSNNMNIDQTDQNTIDEGLYSRQLYVLGHEAMKQMSQSNVLIIGCKGLGVEIAKNVCLAGVKSVTLYDPQPTRIEDLSSQYFLTEDDIGVPRAKVTVSKLAELNQYVPVSVVDELSTEYLKNFKCVVVTETSLTKQLEINDFTHKNHIAYIAADSRGLFGSIFCDFGENFICTDTDGNEPLTGMIASITDDGVVTMLEETRHGLENGDFVKFTEVKGMPGLNDGTPRKVEVKGPYTFSIGSVKDLGSAGYNGVFTQVKVPTKISFKSLRESLKDPEYVYPDFGKMMRPPQYHIAFQALSAFADAHEGSLPRPRNDIDAAE... | DNA damage response protein ubiquitination ubiquitin-dependent protein catabolic process cytoplasm; cytosol; nucleus ATP binding ATP hydrolysis activity magnesium ion binding ubiquitin activating enzyme activity Schizosaccharomyces pombe 3D-structure ATP-binding Cytoplasm Ligase Nucleotide-binding Nucleus Reference pr... |
error-free translesion synthesis error-prone translesion synthesis mitochondrial DNA repair | mitochondrial chromosome; mitotic spindle; nucleolus; nucleus; site of double-strand break | damaged DNA binding deoxycytidyl transferase activity DNA-directed DNA polymerase activity metal ion binding | Schizosaccharomyces pombe | Cytoplasm Cytoskeleton DNA damage DNA repair DNA synthesis DNA-binding Magnesium Metal-binding Mitochondrion Nucleotidyltransferase Nucleus Reference proteome Transferase | MAFNQRKRRR | MAFNQRKRRRPVGIADFDEANDEAYESVGFHDYADYFSRKQRKLQNQNAALYKSIDEDSKSDLFHGLAIAINGYTKPSYTELRQMIVSNGGTFIQYVDGKTSISYLVCSFLTPSKARQWKHQKVVKPEWIVDCIKQKKILPWINYRTFQASSAQATLSFVASKPSQPEGNLEDIQTSSQEEEHDNEKDKTKESKAKGFLDDLSGLSASSLHNYQLLKNPNVRNSTTQNQDFLENFFSSSRLHHLSTWKADFKNEIQAMTTASEPVRPIMKDKSKKSRFLLHVDFDCFFASVSTRFSHELRLKPVAVAHGIKNSEIASCNY... | error-free translesion synthesis error-prone translesion synthesis mitochondrial DNA repair mitochondrial chromosome; mitotic spindle; nucleolus; nucleus; site of double-strand break damaged DNA binding deoxycytidyl transferase activity DNA-directed DNA polymerase activity metal ion binding Schizosaccharomyces pombe C... |
DNA repair epigenetic regulation of gene expression heterochromatin formation negative regulation of transcription by RNA polymerase II | chromatin; chromosome, subtelomeric region; mating-type region heterochromatin; nucleus; pericentric heterochromatin; rDNA heterochromatin; Set3 complex; subtelomeric heterochromatin | histone deacetylase activity histone H3K14 deacetylase activity histone H3K4 deacetylase activity histone H3K9 deacetylase activity histone H4K16 deacetylase activity metal ion binding NAD+ binding NAD-dependent histone H3K9 deacetylase activity NAD-dependent histone H4K16 deacetylase activity transferase activity | Schizosaccharomyces pombe | Centromere Chromatin regulator Chromosome DNA damage DNA repair Metal-binding NAD Nucleus Phosphoprotein Reference proteome Repressor Telomere Transcription Transcription regulation Transferase Zinc | MASNPLDNNM | MASNPLDNNMPTTPVEEKIPVASYSPSSSGSSSGASLLVDIMCGSKETEDEEVDSDEWDKPETENISDLDERSEMVRYLRASGYAKFLEKYLIEEELPVRSILKKLGINLPSALEEFEDIDLLPLLKEVLKREVARRIKLPHFNTFEDVVNLLKKAKNVVVLVGAGISTSLGILDFRSDNGFYARLARHGLSEPSEMFDIHTFRENPEIFYTFARDLLPETNHYSPSHAFIRLLEKKNKLSTLFTQNIDNLEKKTGLSDNKIIQCHGSFATATCIKCKHKVDGSELYEDIRNQRVSYCNECGKPPLKLRRVGQNKKEKHY... | DNA repair epigenetic regulation of gene expression heterochromatin formation negative regulation of transcription by RNA polymerase II chromatin; chromosome, subtelomeric region; mating-type region heterochromatin; nucleus; pericentric heterochromatin; rDNA heterochromatin; Set3 complex; subtelomeric heterochromatin h... |
cellular heat acclimation cellular response to misfolded protein chaperone cofactor-dependent protein refolding protein refolding protein unfolding | cytoplasm; cytosol; nuclear envelope; nucleolar peripheral inclusion body; nucleus; protein aggregate center | ATP binding ATP hydrolysis activity ATP-dependent protein disaggregase activity misfolded protein binding protein-folding chaperone binding unfolded protein binding | Schizosaccharomyces pombe | ATP-binding Chaperone Coiled coil Cytoplasm Nucleotide-binding Nucleus Reference proteome Repeat Stress response | MADYPFTDKA | MADYPFTDKAAKTLSDAYSIAQSYGHSQLTPIHIAAALLSDSDSNGTTLLRTIVDKAGGDGQKFERSVTSRLVRLPAQDPPPEQVTLSPESAKLLRNAHELQKTQKDSYIAQDHFIAVFTKDDTLKSLLAEAGVTPKAFEFAVNNVRGNKRIDSKNAEEGFDALNKFTVDLTELARNGQLDPVIGREDEIRRTIRVLSRRTKNNPVLIGEPGVGKTSIAEGLARRIIDDDVPANLSNCKLLSLDVGSLVAGSKFRGEFEERIKSVLKEVEESETPIILFVDEMHLLMGAGSGGEGGMDAANLLKPMLARGKLHCIGATTL... | cellular heat acclimation cellular response to misfolded protein chaperone cofactor-dependent protein refolding protein refolding protein unfolding cytoplasm; cytosol; nuclear envelope; nucleolar peripheral inclusion body; nucleus; protein aggregate center ATP binding ATP hydrolysis activity ATP-dependent protein disag... |
poly(A)+ mRNA export from nucleus protein transport | cytoplasm; cytosol; nuclear envelope; nuclear membrane; nuclear periphery; nuclear pore; nuclear pore cytoplasmic filaments; nucleus | inositol hexakisphosphate binding phospholipid binding translation initiation factor binding | Schizosaccharomyces pombe | Coiled coil Cytoplasm Membrane mRNA transport Nuclear pore complex Nucleus Protein transport Reference proteome Translocation Transport | MDTKTTPLIH | MDTKTTPLIHAKLDEKIISSYNDANGLDIDDLWDIYNEKTRRMIHIISQRYKPKKQSPFPVIADENVRIFPPLHKTIDWAKKRNVEEQNLIEQSITESQRIFSEKQRLEQERFNRELLEKKRIEAERQRLKDEEERRKKELMEKEKKEKERIRLIEEQKHKENEQRRLKQEQIDAKRKEEEAREKRMKETFKDDPEEDSNMAWSIIHKIKTEVVAPISEKKELKNYCFTQKRKITPRLGQITKSNSQIMKITQLLQQTFQEARNTDPLVYKWVLNFFCKSVVKQAEAEVAVNPISAYPLAKVCLLLQTQNADLKDLLFAR... | poly(A)+ mRNA export from nucleus protein transport cytoplasm; cytosol; nuclear envelope; nuclear membrane; nuclear periphery; nuclear pore; nuclear pore cytoplasmic filaments; nucleus inositol hexakisphosphate binding phospholipid binding translation initiation factor binding Schizosaccharomyces pombe Coiled coil Cyt... |
endocytosis Golgi to vacuole transport intracellular protein transport positive regulation of vacuole fusion, non-autophagic regulation of vacuole fusion, non-autophagic signaling vacuole fusion, non-autophagic | cytosol; fungal-type vacuole membrane; late endosome; phagocytic vesicle; vacuolar membrane; vacuole | GTP binding GTPase activity | Schizosaccharomyces pombe | GTP-binding Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Protein transport Reference proteome Transport Vacuole | MAGKKKHLLK | MAGKKKHLLKVIILGESGVGKTSIMNQYVNRKFSKDYKATIGADFLTKEVLVDDKVVTLQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNNSKSFETLDSWRDEFLIQASPSNPETFPFILLGNKVDVEEQKRMVSKSKALAFCQARGEIPYFETSAKEAINVQEAFETVAKLALENMDSDDIAADFTDPIHLDMESQKTSCYC | endocytosis Golgi to vacuole transport intracellular protein transport positive regulation of vacuole fusion, non-autophagic regulation of vacuole fusion, non-autophagic signaling vacuole fusion, non-autophagic cytosol; fungal-type vacuole membrane; late endosome; phagocytic vesicle; vacuolar membrane; vacuole GTP bind... |
diacylglycerol metabolic process lipid droplet formation lipid storage triglyceride biosynthetic process | cortical endoplasmic reticulum; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; perinuclear endoplasmic reticulum | O-acyltransferase activity phospholipid:diacylglycerol acyltransferase activity | Schizosaccharomyces pombe | Acyltransferase Endoplasmic reticulum Membrane Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix | MASSKKSKTH | MASSKKSKTHKKKKEVKSPIDLPNSKKPTRALSEQPSASETQSVSNKSRKSKFGKRLNFILGAILGICGAFFFAVGDDNAVFDPATLDKFGNMLGSSDLFDDIKGYLSYNVFKDAPFTTDKPSQSPSGNEVQVGLDMYNEGYRSDHPVIMVPGVISSGLESWSFNNCSIPYFRKRLWGSWSMLKAMFLDKQCWLEHLMLDKKTGLDPKGIKLRAAQGFEAADFFITGYWIWSKVIENLAAIGYEPNNMLSASYDWRLSYANLEERDKYFSKLKMFIEYSNIVHKKKVVLISHSMGSQVTYYFFKWVEAEGYGNGGPTWVN... | diacylglycerol metabolic process lipid droplet formation lipid storage triglyceride biosynthetic process cortical endoplasmic reticulum; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; perinuclear endoplasmic reticulum O-acyltransferase activity phospholipid:diacylglycerol acyltransferase activity Sch... |
DNA repair nucleotide-excision repair regulation of transcription by RNA polymerase II transcription initiation at RNA polymerase II promoter | cytosol; nucleotide-excision repair factor 3 complex; nucleus; transcription factor TFIIH holo complex; transcription factor TFIIK complex | cyclin-dependent protein serine/threonine kinase activator activity RNA polymerase II general transcription initiation factor activity ubiquitin protein ligase activity zinc ion binding | Schizosaccharomyces pombe | Cytoplasm DNA damage DNA repair Metal-binding Nucleus Reference proteome Transcription Transcription regulation Zinc Zinc-finger | MDDEGARKVD | MDDEGARKVDEKCPLCQADRYLNPNMKLLINPECYHKMCESCVDRIFTTGPAQCPTPGCNKILRKAKFREQTFEDAQIEREVDVRKRISRIFNKGQQEFDSLQAYNDYLEEVEILTFNLIYKIDVEETEEKVKQYEKQNRDSIAANSARAAAEARILAQNEILLKRQKQEAREAAIREHQKEKERREQVEQQIIFDLATSGKDPNKIIQLSDSLKKQQENIASSVSNISRSSSILLSDVQQVAEDTTPFSPLAGEKDGSKYFSYSKNTYQDLYLEKVSHEPGRKCGFRIEDCHLRCLYEAFSGIDYDLESLKKLEVAS | DNA repair nucleotide-excision repair regulation of transcription by RNA polymerase II transcription initiation at RNA polymerase II promoter cytosol; nucleotide-excision repair factor 3 complex; nucleus; transcription factor TFIIH holo complex; transcription factor TFIIK complex cyclin-dependent protein serine/threoni... |
chromosome segregation heterochromatin formation pericentric heterochromatin formation regulatory ncRNA-mediated heterochromatin formation silent mating-type cassette heterochromatin formation siRNA-dependent pericentric heterochromatin formation | chromosome, subtelomeric region; cytoplasm; mating-type region heterochromatin; nucleus; pericentric heterochromatin; RITS complex; spindle pole body | molecular adaptor activity | Schizosaccharomyces pombe | 3D-structure Cell cycle Chromosome partition Cytoplasm Cytoskeleton Nucleus Reference proteome RNA-mediated gene silencing | MEKGIKKYLP | MEKGIKKYLPSLPFLACISDFPENHGTSRRSATVSLERVHELFTEHWLSNLKNRREKRQELAEEAVYCRSEMLSQRKLLAAVDFPQQLKNSPAKAKATHTSSGVTKEVRASKKYTSSNVEFPLVTDGKEKPVKSKQLRKNSVTEFEKPIETKKSKHRKSRNKFLDKSSGSMEIESWDNSTSDSIIESSSRLHESISLRENDIRSSDSKSVGWDDNSTGFRESSKSLDHTDTSMFMELDSNSDPQFRPKYQAKSSWFAPDDPEASWGNLDDGWGETNGSWSSTDDTKHYKNEWAESINLDNFNRPSQQEDYDKPKNTQVSR... | chromosome segregation heterochromatin formation pericentric heterochromatin formation regulatory ncRNA-mediated heterochromatin formation silent mating-type cassette heterochromatin formation siRNA-dependent pericentric heterochromatin formation chromosome, subtelomeric region; cytoplasm; mating-type region heterochro... |
actin cortical patch localization establishment or maintenance of bipolar cell polarity mitotic actomyosin contractile ring assembly mitotic actomyosin contractile ring disassembly mitotic cytokinesis | cell cortex of cell tip; cell division site; cell tip; mitotic actomyosin contractile ring; mitotic actomyosin contractile ring, intermediate layer; nucleus | cytoskeletal protein-membrane anchor activity phospholipid binding | Schizosaccharomyces pombe | Cell cycle Cell division Cytoplasm Mitosis Nucleus Reference proteome | MSKNPLGTLV | MSKNPLGTLVVRIWKAKNLPNKALVGKQSPYCVCRVGEVVKRTQTDKRSGQEPSWNAVLEFNIPSESYHIMKITVFHEGFRKHPHLIGDTVLSFEKAMKEELQSEWYELKNEFQFAGELSVQFKFIPTDPLYFDRASSKPVLQFPYSSVAALTPVPKKPSKPSKPRKKVPVSHPLPPTPPSREEHVSVPRESSLFTYEDDPLPSFPSPYMVDDYYTQDVFVSDNVNDYSYGVQNPTNPRLSVEDYDANHSSLPPVPPPHLILPTASSSQIFH | actin cortical patch localization establishment or maintenance of bipolar cell polarity mitotic actomyosin contractile ring assembly mitotic actomyosin contractile ring disassembly mitotic cytokinesis cell cortex of cell tip; cell division site; cell tip; mitotic actomyosin contractile ring; mitotic actomyosin contract... |
negative regulation of TORC1 signaling negative regulation of transcription by RNA polymerase II positive regulation of autophagy positive regulation of transcription by RNA polymerase II | cytosol; nucleus | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding zinc ion binding | Schizosaccharomyces pombe | Activator Cytoplasm DNA-binding Metal-binding Nucleus Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger | MNYNDTTEFC | MNYNDTTEFCFPFGQPSFPTSAMTEGSFDGQFSEFDPTFTSPADTALSDIANLPIDLHKDALFANAPGKGDVDFDSVSMLQLLSDYPLAFNSTENNQKLQTNPSARWSLLDSMDFDNQRQCSDLESAQLGDSGLLKSTILSNSHIDIAALSSSKTSEPTPPFSYVQTPCIPTPSSALIDTPFPGALDSEFGFDESQAPLFPASDGDCQRAFASISYPTNYGCKLSNLGFMSPQSPVKRELNDSTSPSKLSESSSSLTGSSSALLSQSEFLGSVPSLSDSIATVDPFFSFESFETDEKARSLLMDASLKLPQFSTPNLSSN... | negative regulation of TORC1 signaling negative regulation of transcription by RNA polymerase II positive regulation of autophagy positive regulation of transcription by RNA polymerase II cytosol; nucleus DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity,... |
cell cycle cell division protein folding protein stabilization | cytoplasm; cytosol; nucleus | heat shock protein binding protein kinase binding protein-folding chaperone binding unfolded protein binding | Schizosaccharomyces pombe | Cell cycle Cell division Chaperone Cytoplasm Nucleus Phosphoprotein Reference proteome | MAIDYSKWDK | MAIDYSKWDKLELSDDSDIEVHPNVDKKSFIRWRQRDIHEKRAVRKQKMEDIKGAMAMNRRLLSRISEMETVLEKESPSDPYVLLGSFLEAKKSEDMDSAIPGGMSYHHMLMSLLKVIKDAEDTTEEKSMDDSDKCLRRLKSHKERLLKLLEDAQKEYDTLEAESKNYITSEDLHLGFDSTYVQKKEPEKPKKTKTKKETIQVIESLNNPTPPTDFPGAKEQASTGNAPKNPVNENESEDEEGLSLSEDGKKFANIDFGDYSSSEEFLKEHLNILADEEESDAILLEAFNAELEGKPSLAKQYVHQALLISYCRQLGPNG... | cell cycle cell division protein folding protein stabilization cytoplasm; cytosol; nucleus heat shock protein binding protein kinase binding protein-folding chaperone binding unfolded protein binding Schizosaccharomyces pombe Cell cycle Cell division Chaperone Cytoplasm Nucleus Phosphoprotein Reference proteome MAIDYS... |
double-strand break repair via homologous recombination filamentous growth maintenance of DNA trinucleotide repeats mRNA export from nucleus positive regulation of transcription by RNA polymerase II proteasome assembly proteasome-mediated ubiquitin-dependent protein catabolic process regulation of cell cycle SAGA compl... | cytosol; proteasome complex; proteasome regulatory particle, lid subcomplex; proteasome storage granule; transcription export complex 2 | molecular adaptor activity protein folding chaperone | Saccharomyces cerevisiae | 3D-structure Acetylation Phosphoprotein Proteasome Reference proteome Transcription | MSTDVAAAQA | MSTDVAAAQAQSKIDLTKKKNEEINKKSLEEDDEFEDFPIDTWANGETIKSNAVTQTNIWEENWDDVEVDDDFTNELKAELDRYKRENQ | double-strand break repair via homologous recombination filamentous growth maintenance of DNA trinucleotide repeats mRNA export from nucleus positive regulation of transcription by RNA polymerase II proteasome assembly proteasome-mediated ubiquitin-dependent protein catabolic process regulation of cell cycle SAGA compl... |
cellular response to oxidative stress hydrogen peroxide catabolic process lignin catabolic process | extracellular region | heme binding manganese peroxidase activity metal ion binding reactive-black-5:hydrogen-peroxide oxidoreductase activity | Pleurotus eryngii | 3D-structure Calcium Direct protein sequencing Disulfide bond Glycoprotein Heme Hydrogen peroxide Iron Lignin degradation Manganese Metal-binding Organic radical Oxidoreductase Peroxidase Secreted Signal Zymogen | MSFKTLSALA | MSFKTLSALALALGAAVQFASAAVPLVQKRATCDDGRTTANAACCILFPILDDIQENLFDGAQCGEEVHESLRLTFHDAIGFSPTLGGGGADGSIIAFDTIETNFPANAGIDEIVSAQKPFVAKHNISAGDFIQFAGAVGVSNCPGGVRIPFFLGRPDAVAASPDHLVPEPFDSVDSILARMGDAGFSPVEVVWLLASHSIAAADKVDPSIPGTPFDSTPGVFDSQFFIETQLKGRLFPGTADNKGEAQSPLQGEIRLQSDHLLARDPQTACEWQSMVNNQPKIQNRFAATMSKMALLGQDKTKLIDCSDVIPTPPALVG... | cellular response to oxidative stress hydrogen peroxide catabolic process lignin catabolic process extracellular region heme binding manganese peroxidase activity metal ion binding reactive-black-5:hydrogen-peroxide oxidoreductase activity Pleurotus eryngii 3D-structure Calcium Direct protein sequencing Disulfide bond ... |
arginine catabolic process arginine metabolic process citrulline metabolic process negative regulation of cell population proliferation negative regulation of cellular response to hypoxia negative regulation of vascular permeability nitric oxide mediated signal transduction nitric oxide metabolic process positive regul... | cytosol; extracellular exosome | amino acid binding catalytic activity dimethylargininase activity metal ion binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Direct protein sequencing Hydrolase Metal-binding Reference proteome S-nitrosylation Zinc | MAGLGHPAAF | MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKKVDS | arginine catabolic process arginine metabolic process citrulline metabolic process negative regulation of cell population proliferation negative regulation of cellular response to hypoxia negative regulation of vascular permeability nitric oxide mediated signal transduction nitric oxide metabolic process positive regul... |
cell division cellular response to camptothecin cellular response to xenobiotic stimulus chromosome separation DNA metabolic process DNA repair DNA replication DNA unwinding involved in DNA replication double-strand break repair via homologous recombination mitotic cell cycle mitotic DNA-templated DNA replication negat... | chromosome; cytoplasm; cytosol; nucleoplasm; nucleus; replication fork; transcription preinitiation complex | 3'-5' DNA helicase activity ATP binding ATP hydrolysis activity DNA helicase activity four-way junction helicase activity helicase activity identical protein binding nucleic acid binding RNA polymerase II complex binding | Homo sapiens | 3D-structure Alternative splicing ATP-binding Cell cycle Cell division Cytoplasm DNA damage DNA repair DNA replication Helicase Hydrolase Nucleotide-binding Nucleus Phosphoprotein Reference proteome | MSSHHTTFPF | MSSHHTTFPFDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSLCYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERKELLADLEREKPQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAHCVSQWGHDFRPDYLRLGALRSRLGHAPCVALTATATPQVQEDVFAALHLKKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALGQEADKGLSGCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVATISFG... | cell division cellular response to camptothecin cellular response to xenobiotic stimulus chromosome separation DNA metabolic process DNA repair DNA replication DNA unwinding involved in DNA replication double-strand break repair via homologous recombination mitotic cell cycle mitotic DNA-templated DNA replication negat... |
cellular response to growth factor stimulus cellular response to steroid hormone stimulus negative regulation of intrinsic apoptotic signaling pathway negative regulation of phosphatase activity negative regulation of transcription by RNA polymerase II protein stabilization regulation of cell growth regulation of trans... | cytoplasm; cytosol; dendrite; mitochondrion; nucleoplasm; nucleus; protein folding chaperone complex; RPAP3/R2TP/prefoldin-like complex | chromatin binding phosphatase inhibitor activity phosphoprotein binding protein phosphatase inhibitor activity RNA polymerase II complex binding transcription corepressor activity | Homo sapiens | Acetylation Alternative splicing Cell projection Cytoplasm Mitochondrion Nucleus Oncogene Phosphoprotein Protein phosphatase inhibitor Reference proteome Repressor Transcription Transcription regulation | MEAPTVETPP | MEAPTVETPPDPSPPSAPAPALVPLRAPDVARLREEQEKVVTNCQERIQHWKKVDNDYNALRERLSTLPDKLSYNIMVPFGPFAFMPGKLVHTNEVTVLLGDNWFAKCSAKQAVGLVEHRKEHVRKTIDDLKKVMKNFESRVEFTEDLQKMSDAAGDIVDIREEIKCDFEFKAKHRIAHKPHSKPKTSDIFEADIANDVKSKDLLADKELWARLEELERQEELLGELDSKPDTVIANGEDTTSSEEEKEDRNTNVNAMHQVTDSHTPCHKDVASSEPFSGQVNSQLNCSVNGSSSYHSDDDDDDDDDDDDDNIDDDDGDN... | cellular response to growth factor stimulus cellular response to steroid hormone stimulus negative regulation of intrinsic apoptotic signaling pathway negative regulation of phosphatase activity negative regulation of transcription by RNA polymerase II protein stabilization regulation of cell growth regulation of trans... |
carbohydrate metabolic process chondroitin sulfate proteoglycan biosynthetic process dermatan sulfate proteoglycan biosynthetic process glycosaminoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process positive regulation of catalytic activity positive regulation of intracellular protein transpor... | cis-Golgi network; extracellular exosome; Golgi apparatus; Golgi membrane; membrane | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity glucuronosyltransferase activity metal ion binding protein phosphatase activator activity | Homo sapiens | 3D-structure Alternative splicing Disease variant Disulfide bond Glycoprotein Golgi apparatus Manganese Membrane Metal-binding Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix | MKLKLKNVFL | MKLKLKNVFLAYFLVSIAGLLYALVQLGQPCDCLPPLRAAAEQLRQKDLRISQLQAELRRPPPAPAQPPEPEALPTIYVVTPTYARLVQKAELVRLSQTLSLVPRLHWLLVEDAEGPTPLVSGLLAASGLLFTHLVVLTPKAQRLREGEPGWVHPRGVEQRNKALDWLRGRGGAVGGEKDPPPPGTQGVVYFADDDNTYSRELFEEMRWTRGVSVWPVGLVGGLRFEGPQVQDGRVVGFHTAWEPSRPFPVDMAGFAVALPLLLDKPNAQFDSTAPRGHLESSLLSHLVDPKDLEPRAANCTRVLVWHTRTEKPKMKQEE... | carbohydrate metabolic process chondroitin sulfate proteoglycan biosynthetic process dermatan sulfate proteoglycan biosynthetic process glycosaminoglycan biosynthetic process heparan sulfate proteoglycan biosynthetic process positive regulation of catalytic activity positive regulation of intracellular protein transpor... |
apoptotic process intracellular signal transduction positive regulation of apoptotic process positive regulation of fibroblast apoptotic process protein autophosphorylation protein phosphorylation | actin cytoskeleton; endoplasmic reticulum-Golgi intermediate compartment; Flemming body; nucleoplasm; nucleus; plasma membrane | ATP binding protein kinase activity protein serine kinase activity protein serine/threonine kinase activity | Homo sapiens | 3D-structure Apoptosis ATP-binding Cell membrane Kinase Membrane Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase | MSRRRFDCRS | MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRS... | apoptotic process intracellular signal transduction positive regulation of apoptotic process positive regulation of fibroblast apoptotic process protein autophosphorylation protein phosphorylation actin cytoskeleton; endoplasmic reticulum-Golgi intermediate compartment; Flemming body; nucleoplasm; nucleus; plasma membr... |
cell-matrix adhesion extracellular matrix organization positive regulation of cell-substrate adhesion | extracellular matrix; extracellular region; interstitial matrix | collagen V binding heparin binding integrin binding | Homo sapiens | Alternative splicing Extracellular matrix Glycoprotein Leucine-rich repeat Reference proteome Repeat Secreted Signal | MKIAVLFCFF | MKIAVLFCFFLLIIFQTDFGKNEEIPRKQRRKIYHRRLRKSSTSHKHRSNRQLGIQQTTVFTPVARLPIVNFDYSMEEKFESFSSFPGVESSYNVLPGKKGHCLVKGITMYNKAVWSPEPCTTCLCSDGRVLCDETMCHPQRCPQTVIPEGECCPVCSATVSYSLLSGIALNDRNEFSGDSSEQREPTNLLHKQLPPPQVGMDRIVRKEALQSEEDEEVKEEDTEQKRETPESRNQGQLYSEGDSRGGDRKQRPGEERRLAHQQQRQGREEEEDEEEEGEEGEEDEEDEEDPVRGDMFRMPSRSPLPAPPRGTLRLPSGC... | cell-matrix adhesion extracellular matrix organization positive regulation of cell-substrate adhesion extracellular matrix; extracellular region; interstitial matrix collagen V binding heparin binding integrin binding Homo sapiens Alternative splicing Extracellular matrix Glycoprotein Leucine-rich repeat Reference prot... |
chromatin organization chromatin remodeling DNA methylation negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II regulation of cell fate specification regu... | chromatin; chromosome, telomeric region; histone deacetylase complex; membrane; nucleoplasm; nucleus; NuRD complex; protein-containing complex; transcription regulator complex | chromatin binding histone deacetylase activity histone deacetylase binding metal ion binding RNA polymerase II-specific DNA-binding transcription factor binding sequence-specific DNA binding transcription coactivator activity transcription corepressor activity | Homo sapiens | Acetylation Alternative splicing DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Ubl conjugation Zinc Zinc-finger | MAANMYRVGD | MAANMYRVGDYVYFENSSSNPYLVRRIEELNKTANGNVEAKVVCLFRRRDISSSLNSLADSNAREFEEESKQPGVSEQQRHQLKHRELFLSRQFESLPATHIRGKCSVTLLNETDILSQYLEKEDCFFYSLVFDPVQKTLLADQGEIRVGCKYQAEIPDRLVEGESDNRNQQKMEMKVWDPDNPLTDRQIDQFLVVARAVGTFARALDCSSSIRQPSLHMSAAAASRDITLFHAMDTLQRNGYDLAKAMSTLVPQGGPVLCRDEMEEWSASEAMLFEEALEKYGKDFNDIRQDFLPWKSLASIVQFYYMWKTTDRYIQQK... | chromatin organization chromatin remodeling DNA methylation negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II regulation of cell fate specification regu... |
dolichol metabolic process GPI anchor biosynthetic process protein O-linked mannosylation regulation of protein stability | dolichol-phosphate-mannose synthase complex; endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex | enzyme activator activity enzyme regulator activity | Homo sapiens | Congenital disorder of glycosylation Congenital muscular dystrophy Direct protein sequencing Disease variant Dystroglycanopathy Endoplasmic reticulum Membrane Reference proteome Transmembrane Transmembrane helix | MATGTDQVVG | MATGTDQVVGLGLVAVSLIIFTYYTAWVILLPFIDSQHVIHKYFLPRAYAVAIPLAAGLLLLLFVGLFISYVMLKTKRVTKKAQ | dolichol metabolic process GPI anchor biosynthetic process protein O-linked mannosylation regulation of protein stability dolichol-phosphate-mannose synthase complex; endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex enzyme activator activity enzyme regulator... |
ammonium import across plasma membrane ammonium transmembrane transport B cell differentiation cellular detoxification cellular response to cAMP hydrogen peroxide transmembrane transport methylammonium transport regulation of cholesterol biosynthetic process transepithelial water transport urea transport water transpor... | apical part of cell; apical plasma membrane; basolateral plasma membrane; brush border membrane; intracellular canaliculus; intracellular vesicle; mitochondrial inner membrane; mitochondrial membrane; mitochondrion; plasma membrane; smooth endoplasmic reticulum; smooth endoplasmic reticulum membrane | ammonium transmembrane transporter activity methylammonium channel activity urea channel activity water channel activity | Homo sapiens | Cell membrane Endoplasmic reticulum Glycoprotein Membrane Mitochondrion Mitochondrion inner membrane Oxidation Reference proteome Repeat Transmembrane Transmembrane helix Transport | MSGEIAMCEP | MSGEIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIFIGCLSVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVMLLPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQGQVAGALVAEIILTTLLALAVCMGAINEKTKGPLAPFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVVANHWNFHWIYWLGPLLAGLLVGLLIRCFIGDGKTRLILKAR | ammonium import across plasma membrane ammonium transmembrane transport B cell differentiation cellular detoxification cellular response to cAMP hydrogen peroxide transmembrane transport methylammonium transport regulation of cholesterol biosynthetic process transepithelial water transport urea transport water transpor... |
DNA repair monoubiquitinated protein deubiquitination positive regulation of error-prone translesion synthesis positive regulation of receptor signaling pathway via JAK-STAT protein deubiquitination proteolysis regulation of DNA repair response to UV skeletal system development | cytosol; nucleoplasm; nucleus | cysteine-type deubiquitinase activity cysteine-type endopeptidase activity peptidase activity | Homo sapiens | 3D-structure Autocatalytic cleavage DNA damage DNA repair Hydrolase Nucleus Phosphoprotein Protease Reference proteome Thiol protease Ubl conjugation Ubl conjugation pathway | MPGVIPSESN | MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQVVPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPKEEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQTRSKRKATSDTLESPPKIIPK... | DNA repair monoubiquitinated protein deubiquitination positive regulation of error-prone translesion synthesis positive regulation of receptor signaling pathway via JAK-STAT protein deubiquitination proteolysis regulation of DNA repair response to UV skeletal system development cytosol; nucleoplasm; nucleus cysteine-ty... |
cell cycle lymphocyte aggregation protein autophosphorylation protein phosphorylation regulation of lymphocyte migration | cytoplasm; cytosol; extracellular exosome; plasma membrane; specific granule membrane | ATP binding identical protein binding protein homodimerization activity protein serine kinase activity protein serine/threonine kinase activity | Homo sapiens | 3D-structure ATP-binding Cell cycle Cell membrane Coiled coil Kinase Membrane Nucleotide-binding Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase | MAFANFRRIL | MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKALRELVAEAKAEVMEEIED... | cell cycle lymphocyte aggregation protein autophosphorylation protein phosphorylation regulation of lymphocyte migration cytoplasm; cytosol; extracellular exosome; plasma membrane; specific granule membrane ATP binding identical protein binding protein homodimerization activity protein serine kinase activity protein se... |
chromatin organization chromatin remodeling dendrite development negative regulation of cell differentiation nervous system development neuron maturation positive regulation of cell differentiation positive regulation of cell population proliferation positive regulation of double-strand break repair positive regulation... | bBAF complex; brahma complex; chromatin; GBAF complex; kinetochore; nBAF complex; NuA4 histone acetyltransferase complex; nuclear matrix; nucleus; RSC-type complex; SWI/SNF complex | chromatin binding structural constituent of cytoskeleton transcription coactivator activity | Homo sapiens | Chromatin regulator Direct protein sequencing Disease variant Epilepsy Intellectual disability Neurogenesis Nucleus Reference proteome Transcription Transcription regulation | MSGGVYGGDE | MSGGVYGGDEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGDKEKKGKIFHIDTNALHVPRDGAEVMSPLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSGNTML... | chromatin organization chromatin remodeling dendrite development negative regulation of cell differentiation nervous system development neuron maturation positive regulation of cell differentiation positive regulation of cell population proliferation positive regulation of double-strand break repair positive regulation... |
protein kinase C-activating G protein-coupled receptor signaling pathway protein phosphorylation sphingolipid biosynthetic process | cytosol; nucleoplasm; plasma membrane | ATP binding diacylglycerol-dependent serine/threonine kinase activity kinase activity metal ion binding protein serine kinase activity | Homo sapiens | 3D-structure Alternative splicing ATP-binding Cytoplasm Kinase Magnesium Membrane Metal-binding Nucleotide-binding Phosphoprotein Reference proteome Repeat Serine/threonine-protein kinase Transferase Zinc Zinc-finger | MSANNSPPSA | MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRD... | protein kinase C-activating G protein-coupled receptor signaling pathway protein phosphorylation sphingolipid biosynthetic process cytosol; nucleoplasm; plasma membrane ATP binding diacylglycerol-dependent serine/threonine kinase activity kinase activity metal ion binding protein serine kinase activity Homo sapiens 3D-... |
cellular response to leukemia inhibitory factor energy reserve metabolic process fructose 6-phosphate metabolic process glutamine metabolic process protein N-linked glycosylation UDP-N-acetylglucosamine biosynthetic process UDP-N-acetylglucosamine metabolic process | cytosol | carbohydrate derivative binding glutamine-fructose-6-phosphate transaminase (isomerizing) activity | Homo sapiens | Aminotransferase Glutamine amidotransferase Phosphoprotein Reference proteome Repeat Transferase | MCGIFAYMNY | MCGIFAYMNYRVPRTRKEIFETLIKGLQRLEYRGYDSAGVAIDGNNHEVKERHIQLVKKRGKVKALDEELYKQDSMDLKVEFETHFGIAHTRWATHGVPSAVNSHPQRSDKGNEFVVIHNGIITNYKDLRKFLESKGYEFESETDTETIAKLIKYVFDNRETEDITFSTLVERVIQQLEGAFALVFKSVHYPGEAVATRRGSPLLIGVRSKYKLSTEQIPILYRTCTLENVKNICKTRMKRLDSSACLHAVGDKAVEFFFASDASAIIEHTNRVIFLEDDDIAAVADGKLSIHRVKRSASDDPSRAIQTLQMELQQIMKG... | cellular response to leukemia inhibitory factor energy reserve metabolic process fructose 6-phosphate metabolic process glutamine metabolic process protein N-linked glycosylation UDP-N-acetylglucosamine biosynthetic process UDP-N-acetylglucosamine metabolic process cytosol carbohydrate derivative binding glutamine-fruc... |
G protein-coupled receptor signaling pathway intracellular signal transduction negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway | cytoplasm; neuron projection; plasma membrane; protein-containing complex | G-protein beta-subunit binding GTPase activator activity GTPase activity | Homo sapiens | Alternative splicing Reference proteome Signal transduction inhibitor | MAAGPAPPPG | MAAGPAPPPGRPRAQMPHLRKMERVVVSMQDPDQGVKMRSQRLLVTVIPHAVTGSDVVQWLAQKFCVSEEEALHLGAVLVQHGYIYPLRDPRSLMLRPDETPYRFQTPYFWTSTLRPAAELDYAIYLAKKNIRKRGTLVDYEKDCYDRLHKKINHAWDLVLMQAREQLRAAKQRSKGDRLVIACQEQTYWLVNRPPPGAPDVLEQGPGRGSCAASRVLMTKSADFHKREIEYFRKALGRTRVKSSVCLEAYLSFCGQRGPHDPLVSGCLPSNPWISDNDAYWVMNAPTVAAPTKLRVERWGFSFRELLEDPVGRAHFMDF... | G protein-coupled receptor signaling pathway intracellular signal transduction negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway cytoplasm; neuron projection; plasma membrane; protein-containing complex G-protein beta-subunit binding GTPase activator activity GTPase a... |
astral microtubule organization cell division microtubule bundle formation microtubule nucleation by microtubule organizing center microtubule polymerization myelin assembly negative regulation of tubulin deacetylation oligodendrocyte development oligodendrocyte differentiation positive regulation of myelination positi... | cytoplasm; cytosol; Golgi apparatus; microtubule; microtubule organizing center; mitochondrion; mitotic spindle; nucleus; perinuclear region of cytoplasm; postsynaptic Golgi apparatus | GTPase activity magnesium ion binding microtubule binding microtubule nucleator activity protein dimerization activity protein homodimerization activity tubulin binding | Homo sapiens | Cell cycle Cell division Cytoplasm Cytoskeleton Glycoprotein Golgi apparatus Hydrolase Magnesium Metal-binding Mitosis Nucleus Phosphoprotein Reference proteome Zinc | MADKAKPAKA | MADKAKPAKAANRTPPKSPGDPSKDRAAKRLSLESEGAGEGAAASPELSALEEAFRRFAVHGDARATGREMHGKNWSKLCKDCQVIDGRNVTVTDVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVREVHRLIEGKAPIISGVTKAISSPTVSRLTDTTKFTGSHKERFDPSGKGKGKAGRVDLVDESGYVSGYKHAGTYDQKVQGGK | astral microtubule organization cell division microtubule bundle formation microtubule nucleation by microtubule organizing center microtubule polymerization myelin assembly negative regulation of tubulin deacetylation oligodendrocyte development oligodendrocyte differentiation positive regulation of myelination positi... |
activation of innate immune response cellular response to virus negative regulation of cell growth involved in cardiac muscle cell development positive regulation of defense response to virus by host positive regulation of interferon-beta production positive regulation of protein targeting to mitochondrion protein impo... | extracellular exosome; membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrial outer membrane translocase complex; mitochondrion; TOM complex | mitochondrion targeting sequence binding molecular adaptor activity protein transmembrane transporter activity | Homo sapiens | 3D-structure Acetylation Host-virus interaction Isopeptide bond Membrane Methylation Mitochondrion Mitochondrion outer membrane Phosphoprotein Reference proteome Repeat TPR repeat Transmembrane Transmembrane helix Ubl conjugation | MAASKPVEAA | MAASKPVEAAVVAAAVPSSGSGVGGGGTAGPGTGGLPRWQLALAVGAPLLLGAGAIYLWSRQQRRREARGRGDASGLKRNSERKTPEGRASPAPGSGHPEGPGAHLDMNSLDRAQAAKNKGNKYFKAGKYEQAIQCYTEAISLCPTEKNVDLSTFYQNRAAAFEQLQKWKEVAQDCTKAVELNPKYVKALFRRAKAHEKLDNKKECLEDVTAVCILEGFQNQQSMLLADKVLKLLGKEKAKEKYKNREPLMPSPQFIKSYFSSFTDDIISQPMLKGEKSDEDKDKEGEALEVKENSGYLKAKQYMEEENYDKIISECSKE... | activation of innate immune response cellular response to virus negative regulation of cell growth involved in cardiac muscle cell development positive regulation of defense response to virus by host positive regulation of interferon-beta production positive regulation of protein targeting to mitochondrion protein impo... |
endothelial cell chemotaxis endothelial cell migration positive regulation of canonical NF-kappaB signal transduction regulation of small GTPase mediated signal transduction Rho protein signal transduction | axon; cell-cell junction; cytoplasm; cytosol; endocytic vesicle; lamellipodium; perinuclear region of cytoplasm; plasma membrane | guanyl-nucleotide exchange factor activity | Homo sapiens | Alternative splicing Cell junction Cell membrane Cell projection Charcot-Marie-Tooth disease Cytoplasm Disease variant Membrane Neurodegeneration Neuropathy Phosphoprotein Reference proteome | MHYDGHVRFD | MHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAVDLEEEEEESSVDGKGDRKSTGLKLSKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAPAKPGDEGKVEQGMKDSKSLSLPILRPAGTGPPALERVDAQSRRESLDILAPGRRRKNMSEFLGEASIPGQEPPTPSSCSLPSGSSGSTNTGDSWKNRAASRFSGFFSSGPSTSAFGREVDKMEQLEGKLHTYSLFGLPRLPRGLRFDHDSWEEEYDEDEDEDNACLRLEDSW... | endothelial cell chemotaxis endothelial cell migration positive regulation of canonical NF-kappaB signal transduction regulation of small GTPase mediated signal transduction Rho protein signal transduction axon; cell-cell junction; cytoplasm; cytosol; endocytic vesicle; lamellipodium; perinuclear region of cytoplasm; p... |
protein import into nucleus | cytoplasm; nucleus | small GTPase binding | Homo sapiens | 3D-structure Cytoplasm Nucleus Protein transport Reference proteome Repeat Transport | MERREEQPGA | MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAVADMVRLFQAEDSPVDGQGRCLALLELLTVLPEEFQTSRLPQYRKGLVRTSLAVECGAVFPLLEQLLQQPSSPSCVRQKVLKCFSSWVQLEVPLQDCEALIQAAFAALQDSELFDSSVEAIVNAISQPDAQRYVNTLLKLIPLVLGLQEQLRQAVQNGDMETSHGICRIAVALGENHS... | protein import into nucleus cytoplasm; nucleus small GTPase binding Homo sapiens 3D-structure Cytoplasm Nucleus Protein transport Reference proteome Repeat Transport MERREEQPGA MERREEQPGAAGAGAAPALDFTVENVEKALHQLYYDPNIENKNLAQKWLMQAQVSPQAWHFSWQLLQPDKVPEIQYFGASALHIKISRYWSDIPTDQYESLKAQLFTQITRFASGSKIVLTRLCVALASLALSMMPDAWPCAV... |
lipid droplet organization locomotory behavior mitochondrial fission positive regulation of mitochondrial fission triglyceride catabolic process visual learning | centriolar satellite; COPII-coated ER to Golgi transport vesicle; cytosol; endoplasmic reticulum-Golgi intermediate compartment; Golgi apparatus; membrane | metal ion binding triglyceride lipase activity | Homo sapiens | Alternative splicing Cytoplasm Disease variant Golgi apparatus Hereditary spastic paraplegia Hydrolase Lipid degradation Lipid metabolism Neurodegeneration Phosphoprotein Reference proteome | MSSVQSQQEQ | MSSVQSQQEQLSQSDPSPSPNSCSSFELIDMDAGSLYEPVSPHWFYCKIIDSKETWIPFNSEDSQQLEEAYSSGKGCNGRVVPTDGGRYDVHLGERMRYAVYWDELASEVRRCTWFYKGDKDNKYVPYSESFSQVLEETYMLAVTLDEWKKKLESPNREIIILHNPKLMVHYQPVAGSDDWGSTPTEQGRPRTVKRGVENISVDIHCGEPLQIDHLVFVVHGIGPACDLRFRSIVQCVNDFRSVSLNLLQTHFKKAQENQQIGRVEFLPVNWHSPLHSTGVDVDLQRITLPSINRLRHFTNDTILDVFFYNSPTYCQTIV... | lipid droplet organization locomotory behavior mitochondrial fission positive regulation of mitochondrial fission triglyceride catabolic process visual learning centriolar satellite; COPII-coated ER to Golgi transport vesicle; cytosol; endoplasmic reticulum-Golgi intermediate compartment; Golgi apparatus; membrane meta... |
actin filament organization cellular localization early endosome to recycling endosome transport protein transport vesicle transport along actin filament | actin cytoskeleton; apical dendrite; axolemma; axon; basolateral plasma membrane; brush border; cell cortex; cytoplasm; cytoplasmic vesicle; cytosol; early endosome; endosome; extracellular exosome; microvillus; myelin sheath; myosin complex; neuron projection; neuronal cell body; perikaryon; plasma membrane; smooth en... | actin filament binding ATP binding calcium-dependent protein binding calmodulin binding microfilament motor activity protein domain specific binding | Homo sapiens | Acetylation Actin-binding ATP-binding Calmodulin-binding Cell projection Cytoplasm Direct protein sequencing Endosome Motor protein Myosin Nucleotide-binding Phosphoprotein Protein transport Reference proteome Repeat Transport | MAEQESLEFG | MAEQESLEFGKADFVLMDTVSMPEFMANLRLRFEKGRIYTFIGEVVVSVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEASKYIMQYIAAITNPSQRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSRVIVQQPGERSFHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMKVIGFKPEEIQTVYKILAAILHLGNLKFVVDGDTPLIENGKVVSIIAELLSTKTDMVEKALLYRTV... | actin filament organization cellular localization early endosome to recycling endosome transport protein transport vesicle transport along actin filament actin cytoskeleton; apical dendrite; axolemma; axon; basolateral plasma membrane; brush border; cell cortex; cytoplasm; cytoplasmic vesicle; cytosol; early endosome; ... |
regulation of transcription by RNA polymerase II | chromatin; nucleus; PTW/PP1 phosphatase complex | chromatin DNA binding | Homo sapiens | Alternative splicing DNA-binding Methylation Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MEFPGGNDNY | MEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLADPSSSQDGSFSAQYGVQTLDMPVGMTHGLMEQGGGLLSGGLTMDLDHSIGTQYSANPPVTIDVPMTDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTSSLHEDGVEDFRRQLPSQKTVVVEAGKKQKAPKKRKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYKDNQECQATVETVELDPAPPSQTPSPPPMA... | regulation of transcription by RNA polymerase II chromatin; nucleus; PTW/PP1 phosphatase complex chromatin DNA binding Homo sapiens Alternative splicing DNA-binding Methylation Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation MEFPGGNDNY MEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLA... |
positive regulation of transcription by RNA polymerase II | cell projection; cytoplasm; dendritic spine membrane; endoplasmic reticulum membrane; nucleus; perikaryon; postsynaptic membrane | DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | Cell membrane Cell projection Coiled coil Cytoplasm Endoplasmic reticulum Membrane Nucleus Phosphoprotein Postsynaptic cell membrane Reference proteome Synapse | MLDGPLFSEG | MLDGPLFSEGPDSPRELQDEESGSCLWVQKSKLLVIEVKTISCHYSRRAPSRQPMDFQASHWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQEREAKETERKRRKAGGARRSPPGRPRPEPRNAPRVAQLAGLPAPLRPERLAPVGRAPRPSAQPQSDPGSAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRRRWDRPPPYVAPPSYEGPHRTLGTKRGPGNSQVPTSSAPAATPARTDGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGCGAARARPEPGKGVVEKSLGL... | positive regulation of transcription by RNA polymerase II cell projection; cytoplasm; dendritic spine membrane; endoplasmic reticulum membrane; nucleus; perikaryon; postsynaptic membrane DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA b... |
maintenance of protein location in nucleus positive regulation of DNA-templated transcription regulation of DNA repair regulation of RNA splicing | nucleoplasm; nucleus; SAGA complex | protein heterodimerization activity transcription coactivator activity | Homo sapiens | 3D-structure Alternative splicing Isopeptide bond Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Ubl conjugation | MNLQRYWGEI | MNLQRYWGEIPISSSQTNRSSFDLLPREFRLVEVHDPPLHQPSANKPKPPTMLDIPSEPCSLTIHTIQLIQHNRRLRNLIATAQAQNQQQTEGVKTEESEPLPSCPGSPPLPDDLLPLDCKNPNAPFQIRHSDPESDFYRGKGEPVTELSWHSCRQLLYQAVATILAHAGFDCANESVLETLTDVAHEYCLKFTKLLRFAVDREARLGQTPFPDVMEQVFHEVGIGSVLSLQKFWQHRIKDYHSYMLQISKQLSEEYERIVNPEKATEDAKPVKIKEEPVSDITFPVSEELEADLASGDQSLPMGVLGAQSERFPSNLEV... | maintenance of protein location in nucleus positive regulation of DNA-templated transcription regulation of DNA repair regulation of RNA splicing nucleoplasm; nucleus; SAGA complex protein heterodimerization activity transcription coactivator activity Homo sapiens 3D-structure Alternative splicing Isopeptide bond Nucle... |
clathrin-dependent endocytosis membrane organization neuromuscular synaptic transmission positive regulation of actin filament polymerization positive regulation of Arp2/3 complex-mediated actin nucleation protein transport regulation of actin filament polymerization | anchoring junction; clathrin-coated pit; neuromuscular junction; plasma membrane; recycling endosome; stereocilium shaft | phosphatidylinositol-3,4,5-trisphosphate binding phosphatidylinositol-3,4-bisphosphate binding | Homo sapiens | 3D-structure Alternative splicing Cell junction Cell membrane Cell projection Coated pit Coiled coil Cytoplasm Endocytosis Lipid-binding Membrane Phosphoprotein Protein transport Reference proteome Repeat SH3 domain Transport | MQPPPRKVKV | MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESETGTTE... | clathrin-dependent endocytosis membrane organization neuromuscular synaptic transmission positive regulation of actin filament polymerization positive regulation of Arp2/3 complex-mediated actin nucleation protein transport regulation of actin filament polymerization anchoring junction; clathrin-coated pit; neuromuscul... |
DNA damage checkpoint signaling DNA repair erythrocyte differentiation hematopoietic stem cell differentiation negative regulation of apoptotic process negative regulation of IRE1-mediated unfolded protein response negative regulation of NF-kappaB transcription factor activity negative regulation of protein ubiquitinat... | cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial outer membrane; neuron projection; nucleus; protein-containing complex; site of double-strand break | protein kinase binding UFM1 ligase activity UFM1 transferase activity | Homo sapiens | Acetylation Alternative splicing Chromosome Cytoplasm DNA damage DNA repair Endoplasmic reticulum Membrane Methylation Nucleus Phosphoprotein Reference proteome Transferase Ubl conjugation Ubl conjugation pathway | MADAWEEIRR | MADAWEEIRRLAADFQRAQFAEATQRLSERNCIEIVNKLIAQKQLEVVHTLDGKEYITPAQISKEMRDELHVRGGRVNIVDLQQVINVDLIHIENRIGDIIKSEKHVQLVLGQLIDENYLDRLAEEVNDKLQESGQVTISELCKTYDLPGNFLTQALTQRLGRIISGHIDLDNRGVIFTEAFVARHKARIRGLFSAITRPTAVNSLISKYGFQEQLLYSVLEELVNSGRLRGTVVGGRQDKAVFVPDIYSRTQSTWVDSFFRQNGYLEFDALSRLGIPDAVSYIKKRYKTTQLLFLKAACVGQGLVDQVEASVEEAISSG... | DNA damage checkpoint signaling DNA repair erythrocyte differentiation hematopoietic stem cell differentiation negative regulation of apoptotic process negative regulation of IRE1-mediated unfolded protein response negative regulation of NF-kappaB transcription factor activity negative regulation of protein ubiquitinat... |
endoplasmic reticulum organization endosomal transport endosome fission endosome membrane tubulation membrane fission | cytosol; endomembrane system; endoplasmic reticulum membrane; endoplasmic reticulum-endosome membrane contact site; rough endoplasmic reticulum | identical protein binding | Homo sapiens | Acetylation Alternative splicing Coiled coil Endoplasmic reticulum Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport | MEPSGSEQLF | MEPSGSEQLFEDPDPGGKSQDAEARKQTESEQKLSKMTHNALENINVIGQGLKHLFQHQRRRSSVSPHDVQQIQADPEPEMDLESQNACAEIDGVPTHPTALNRVLQQIRVPPKMKRGTSLHSRRGKPEAPKGSPQINRKSGQEMTAVMQSGRPRSSSTTDAPTSSAMMEIACAAAAAAAACLPGEEGTAERIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIAQTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQNGIPRQPKD... | endoplasmic reticulum organization endosomal transport endosome fission endosome membrane tubulation membrane fission cytosol; endomembrane system; endoplasmic reticulum membrane; endoplasmic reticulum-endosome membrane contact site; rough endoplasmic reticulum identical protein binding Homo sapiens Acetylation Alterna... |
germinal center B cell differentiation lung alveolus development mesenchymal cell proliferation mesenchymal cell proliferation involved in lung development negative regulation of cell population proliferation negative regulation of mesenchymal cell proliferation negative regulation of mesenchymal cell proliferation inv... | chromatin; chromosome; cytoplasm; nucleus | histone binding histone reader activity zinc ion binding | Homo sapiens | Alternative initiation Alternative splicing Chromosome Coiled coil Cytoplasm Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Ubl conjugation Zinc Zinc-finger | MDRSSKRRQV | MDRSSKRRQVKPLAASLLEALDYDSSDDSDFKVGDASDSEGSGNGSEDASKDSGEGSCSDSEENILEEELNEDIKVKEEQLKNSAEEEVLSSEKQLIKMEKKEEEENGERPRKKKEKEKEKEKEKEKEKEREKEKEKATVSENVAASAAATTPATSPPAVNTSPSVPTTTTATEEQVSEPKKWNLRRNRPLLDFVSMEELNDMDDYDSEDDNDWRPTVVKRKGRSASQKEGSDGDNEDDEDEGSGSDEDENDEGNDEDHSSPASEGGCKKKKSKVLSRNSADDEELTNDSLTLSQSKSNEDSLILEKSQNWSSQKMDHIL... | germinal center B cell differentiation lung alveolus development mesenchymal cell proliferation mesenchymal cell proliferation involved in lung development negative regulation of cell population proliferation negative regulation of mesenchymal cell proliferation negative regulation of mesenchymal cell proliferation inv... |
proteasome-mediated ubiquitin-dependent protein catabolic process | cytosol; nucleoplasm; nucleus; VCP-NPL4-UFD1 AAA ATPase complex | RNA polymerase II-specific DNA-binding transcription factor binding ubiquitin binding ubiquitin protein ligase binding | Homo sapiens | 3D-structure Acetylation Isopeptide bond Nucleus Phosphoprotein Reference proteome Ubl conjugation | MAAHGGSAAS | MAAHGGSAASSALKGLIQQFTTITGASESVGKHMLEACNNNLEMAVTMFLDGGGIAEEPSTSSASVSTVRPHTEEEVRAPIPQKQEILVEPEPLFGAPKRRRPARSIFDGFRDFQTETIRQEQELRNGGAIDKKLTTLADLFRPPIDLMHKGSFETAKECGQMQNKWLMINIQNVQDFACQCLNRDVWSNEAVKNIIREHFIFWQVYHDSEEGQRYIQFYKLGDFPYVSILDPRTGQKLVEWHQLDVSSFLDQVTGFLGEHGQLDGLSSSPPKKCARSESLIDASEDSQLEAAIRASLQETHFDSTQTKQDSRSDEESES... | proteasome-mediated ubiquitin-dependent protein catabolic process cytosol; nucleoplasm; nucleus; VCP-NPL4-UFD1 AAA ATPase complex RNA polymerase II-specific DNA-binding transcription factor binding ubiquitin binding ubiquitin protein ligase binding Homo sapiens 3D-structure Acetylation Isopeptide bond Nucleus Phosphopr... |
DNA damage response regulation of transcription by RNA polymerase II | nucleoplasm; nucleus | damaged DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding protein-macromolecule adaptor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | DNA-binding Metal-binding Nitration Nucleus Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger | MINAQELLTL | MINAQELLTLEDVTVEFTWEEWQLLGPFQKDLYRDVMLEIYSNLLSMGYQVSKPDALSKLERGEEPWTMEDERHSRICPENNEVDDHLQDHLENQRMLKSVEQYHEHNAFGNTASQTKSLCLFRENHDTFELYIKTLKSNLSLVNQNKSCEINNSTKFSGDGKSFLHGNYEELYSAAKFSVSTKANSTKSQVSKHQRTHEIEKNHVCSECGKAFVKKSQLTDHERVHTGEKPYGCTLCAKVFSRKSRLNEHQRIHKREKSFICSECGKVFTMKSRLIEHQRTHTGEKPYICNECGKGFPGKRNLIVHQRNHTGEKSYICS... | DNA damage response regulation of transcription by RNA polymerase II nucleoplasm; nucleus damaged DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding protein-macromolecule adaptor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding Homo sapiens ... |
CD4-positive, alpha-beta T cell lineage commitment CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment CD8-positive, alpha-beta T cell lineage commitment cerebral cortex neuron differentiation chromatin organization leukocyte differentiation lymph node development natural killer cell differenti... | nucleus | chromatin DNA binding | Homo sapiens | Chromatin regulator DNA-binding Neurogenesis Nucleus Reference proteome Transcription Transcription regulation | MDVRFYPPPA | MDVRFYPPPAQPAAAPDAPCLGPSPCLDPYYCNKFDGENMYMSMTEPSQDYVPASQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNHNGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMPDIRNPEGTQYSSHPQMAAMRPRGQPADIRQQPGMMPHGQLTTINQSQLSAQLGLNMGGSNVPHNSPSPPGSKSATPSPSSSVHEDEGDDTSKINGGEKRPASDMGKKPKTPKKKKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDGLGEEQKQVYKKKTEAAKKE... | CD4-positive, alpha-beta T cell lineage commitment CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment CD8-positive, alpha-beta T cell lineage commitment cerebral cortex neuron differentiation chromatin organization leukocyte differentiation lymph node development natural killer cell differenti... |
centrosome localization homologous chromosome pairing at meiosis meiotic attachment of telomere to nuclear envelope nuclear matrix anchoring at nuclear membrane nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration ossification response to mechanical stimulus spermatogenesis | chromosome, telomeric region; cytoplasm; intracellular membrane-bounded organelle; meiotic nuclear membrane microtubule tethering complex; nuclear envelope; nuclear inner membrane; nuclear membrane | cytoskeleton-nuclear membrane anchor activity identical protein binding lamin binding protein-membrane adaptor activity | Homo sapiens | 3D-structure Alternative splicing Coiled coil Differentiation Disulfide bond Isopeptide bond Meiosis Membrane Nucleus Phosphoprotein Reference proteome Signal-anchor Spermatogenesis Transmembrane Transmembrane helix Ubl conjugation | MDFSRLHMYS | MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPV... | centrosome localization homologous chromosome pairing at meiosis meiotic attachment of telomere to nuclear envelope nuclear matrix anchoring at nuclear membrane nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration ossification response to mechanical stimulus spermatogenesis chromosome... |
cholesterol metabolic process negative regulation of cholesterol biosynthetic process negative regulation of fatty acid biosynthetic process regulation of cholesterol biosynthetic process SREBP signaling pathway ubiquitin-dependent ERAD pathway | cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane raft; plasma membrane; protein-containing complex | cholesterol binding ubiquitin protein ligase binding | Homo sapiens | Acetylation Alternative splicing Cholesterol metabolism Direct protein sequencing Endoplasmic reticulum Glycoprotein Hereditary spastic paraplegia Lipid metabolism Membrane Neurodegeneration Reference proteome Signal-anchor Steroid metabolism Sterol metabolism Transmembrane Transmembrane helix | MAQLGAVVAV | MAQLGAVVAVASSFFCASLFSAVHKIEEGHIGVYYRGGALLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSAGSVSKQFEGLA... | cholesterol metabolic process negative regulation of cholesterol biosynthetic process negative regulation of fatty acid biosynthetic process regulation of cholesterol biosynthetic process SREBP signaling pathway ubiquitin-dependent ERAD pathway cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane ra... |
mRNA splicing, via spliceosome positive regulation of transcription by RNA polymerase II RNA localization RNA splicing RNA splicing, via transesterification reactions spliceosomal complex assembly spliceosomal tri-snRNP complex assembly | catalytic step 2 spliceosome; membrane; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex; U5 snRNP | identical protein binding ribonucleoprotein complex binding RNA binding | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Disease variant mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Repeat Retinitis pigmentosa Spliceosome | MNKKKKPFLG | MNKKKKPFLGMPAPLGYVPGLGRGATGFTTRSDIGPARDANDPVDDRHAPPGKRTVGDQMKKNQAADDDDEDLNDTNYDEFNGYAGSLFSSGPYEKDDEEADAIYAALDKRMDERRKERREQREKEEIEKYRMERPKIQQQFSDLKRKLAEVTEEEWLSIPEVGDARNKRQRNPRYEKLTPVPDSFFAKHLQTGENHTSVDPRQTQFGGLNTPYPGGLNTPYPGGMTPGLMTPGTGELDMRKIGQARNTLMDMRLSQVSDSVSGQTVVDPKGYLTDLNSMIPTHGGDINDIKKARLLLKSVRETNPHHPPAWIASARLEE... | mRNA splicing, via spliceosome positive regulation of transcription by RNA polymerase II RNA localization RNA splicing RNA splicing, via transesterification reactions spliceosomal complex assembly spliceosomal tri-snRNP complex assembly catalytic step 2 spliceosome; membrane; nuclear speck; nucleoplasm; nucleus; splice... |
innate immune response | cytosol; extracellular exosome; extracellular region; membrane | endonuclease activity metal ion binding nucleic acid binding | Homo sapiens | Acetylation Endonuclease Hydrolase Immunity Innate immunity Nuclease Reference proteome Secreted Signal | MGTARWLALG | MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPPAGLAADSHVKICQRAEGAERFATLYSTRDRIPVYSAFRAPRPAPGGAEQRWLVEPQIDDPNSNLEEAINEAEAITSVNSLGSKQALNTDYLDSDYQRGQLYPFSLSSDVQVATFTLTNSAPMTQSFQERWYVNLHSLMDRALTPQCGSGEDLYILTGTVPSDYRVKDKVAVPEFVWLAACCAVPGGGWAMGFVKHTRDSDIIEDVMVKDLQKLLPFNPQLFQNNCGETEQDTEKMKKILEVVNQIQDEERMVQSQKSSSPLSSTRSKRSTLLPPEA... | innate immune response cytosol; extracellular exosome; extracellular region; membrane endonuclease activity metal ion binding nucleic acid binding Homo sapiens Acetylation Endonuclease Hydrolase Immunity Innate immunity Nuclease Reference proteome Secreted Signal MGTARWLALG MGTARWLALGSLFALAGLLEGRLVGEEEAGFGECDKFFYAGTPPA... |
cell division G2/M transition of mitotic cell cycle phosphorylation regulation of canonical Wnt signaling pathway Wnt signaling pathway | cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoplasmic cyclin-dependent protein kinase holoenzyme complex; cytosol; nucleoplasm; nucleus; plasma membrane | ATP binding cyclin binding cyclin-dependent protein serine/threonine kinase activity protein serine kinase activity | Homo sapiens | Alternative splicing ATP-binding Cell cycle Cell division Cell membrane Cytoplasm Kinase Membrane Nucleotide-binding Nucleus Phosphoprotein Reference proteome Serine/threonine-protein kinase Transferase Wnt signaling pathway | MCDLIEPQPA | MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGC... | cell division G2/M transition of mitotic cell cycle phosphorylation regulation of canonical Wnt signaling pathway Wnt signaling pathway cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytoplasmic cyclin-dependent protein kinase holoenzyme complex; cytosol; nucleoplasm; nucleus; plasma membrane ATP bindin... |
heparan sulfate proteoglycan biosynthetic process heparin biosynthetic process negative regulation of cell projection organization positive regulation of cell population proliferation positive regulation of SMAD protein signal transduction | Golgi apparatus; Golgi membrane | calcium ion binding heparosan-N-sulfate-glucuronate 5-epimerase activity protein homodimerization activity racemase and epimerase activity, acting on carbohydrates and derivatives | Homo sapiens | 3D-structure Calcium Glycoprotein Golgi apparatus Isomerase Membrane Metal-binding Reference proteome Signal-anchor Transmembrane Transmembrane helix | MRCLAARVNY | MRCLAARVNYKTLIIICALFTLVTVLLWNKCSSDKAIQFPRRSSSGFRVDGFEKRAAASESNNYMNHVAKQQSEEAFPQEQQKAPPVVGGFNSNVGSKVLGLKYEEIDCLINDEHTIKGRREGNEVFLPFTWVEKYFDVYGKVVQYDGYDRFEFSHSYSKVYAQRAPYHPDGVFMSFEGYNVEVRDRVKCISGVEGVPLSTQWGPQGYFYPIQIAQYGLSHYSKNLTEKPPHIEVYETAEDRDKNKPNDWTVPKGCFMANVADKSRFTNVKQFIAPETSEGVSLQLGNTKDFIISFDLKFLTNGSVSVVLETTEKNQLFT... | heparan sulfate proteoglycan biosynthetic process heparin biosynthetic process negative regulation of cell projection organization positive regulation of cell population proliferation positive regulation of SMAD protein signal transduction Golgi apparatus; Golgi membrane calcium ion binding heparosan-N-sulfate-glucuron... |
chemical synaptic transmission glutamate biosynthetic process glutamine catabolic process intracellular glutamate homeostasis protein homotetramerization regulation of respiratory gaseous exchange by nervous system process suckling behavior | cytosol; mitochondrial matrix; mitochondrion; synapse | glutaminase activity | Homo sapiens | 3D-structure Acetylation Alternative splicing ANK repeat Cataract Cytoplasm Direct protein sequencing Disease variant Epilepsy Hydrolase Mitochondrion Phosphoprotein Reference proteome Repeat Transit peptide | MMRLRGSGML | MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGGGGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNK... | chemical synaptic transmission glutamate biosynthetic process glutamine catabolic process intracellular glutamate homeostasis protein homotetramerization regulation of respiratory gaseous exchange by nervous system process suckling behavior cytosol; mitochondrial matrix; mitochondrion; synapse glutaminase activity Homo... |
cilium assembly cytoskeleton organization lamellipodium assembly positive regulation of protein targeting to mitochondrion positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II | actin cytoskeleton; cytoplasm; glutamatergic synapse; lamellipodium; stress fiber | actin filament binding metal ion binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm LIM domain Metal-binding Methylation Phosphoprotein Reference proteome Repeat Zinc | MNTSIPYQQN | MNTSIPYQQNPYNPRGSSNVIQCYRCGDTCKGEVVRVHNNHFHIRCFTCQVCGCGLAQSGFFFKNQEYICTQDYQQLYGTRCDSCRDFITGEVISALGRTYHPKCFVCSLCRKPFPIGDKVTFSGKECVCQTCSQSMASSKPIKIRGPSHCAGCKEEIKHGQSLLALDKQWHVSCFKCQTCSVILTGEYISKDGVPYCESDYHAQFGIKCETCDRYISGRVLEAGGKHYHPTCARCVRCHQMFTEGEEMYLTGSEVWHPICKQAARAEKKLKHRRTSETSISPPGSSIGSPNRVICAKVDNEILNYKDLAALPKVKSIYE... | cilium assembly cytoskeleton organization lamellipodium assembly positive regulation of protein targeting to mitochondrion positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II actin cytoskeleton; cytoplasm; glutamatergic synapse; lamellipodium; stress fiber actin filament binding... |
protein polyubiquitination | focal adhesion; nuclear body; nucleoplasm; nucleus | metal ion binding ubiquitin protein ligase binding ubiquitin-ubiquitin ligase activity | Homo sapiens | Alternative splicing Metal-binding Methylation Nucleus Reference proteome Transferase Ubl conjugation pathway Zinc Zinc-finger | MVINLCLPQF | MVINLCLPQFRPRIHCNKISADGYEVENLISEDLTKRSHGFRTEYFIKPPVYVTVSFPFNVEICRINIDLTAGGGQNVTGLEMYTSASSSRVSWNTPQCRTLGPAEPSVPDKEAFTLVGKVLLKNQSQVVFSHRGFKARPPFGAMEATLPSPAVVAQELWNKGALSLSHVAHLRICITHVTGGGIPCIKRLEVWGQPAKTCSQEVIDSILLVTSENLPQDVALQAPALPMESDCDPGDQPESQQAPSSLQKLAEIIQDVPEEFLDPITLEIMPCPMLLPSGKVIDQSTLEKCNRSEATWGRVPSDPFTGVAFTPHSQPLP... | protein polyubiquitination focal adhesion; nuclear body; nucleoplasm; nucleus metal ion binding ubiquitin protein ligase binding ubiquitin-ubiquitin ligase activity Homo sapiens Alternative splicing Metal-binding Methylation Nucleus Reference proteome Transferase Ubl conjugation pathway Zinc Zinc-finger MVINLCLPQF MVIN... |
male gonad development proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteolysis retrograde transport, endosome to Golgi | cytoplasm; cytosol; extracellular exosome; trans-Golgi network membrane | ATP binding ATP hydrolysis activity GTPase activity small GTPase binding ubiquitin protein ligase binding | Homo sapiens | ATP-binding Golgi apparatus Hydrolase Nucleotide-binding Reference proteome Repeat Transport | MSIHIVALGN | MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLLNAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKKRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNSDLNNLLFCCQCVDVVFYNPNLKKVVEAHKIVLCAVSHVFMLLFNVKSPTDIQDSSIIRTTQDLFAINRDTAFPGASHE... | male gonad development proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteolysis retrograde transport, endosome to Golgi cytoplasm; cytosol; extracellular exosome; trans-Golgi network membrane ATP binding ATP hydrolysis activity GTPase activity small GTPase binding ubiquitin protein li... |
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