Biological Process stringlengths 7 1.01k | Cellular Component stringlengths 6 867 | Molecular Function stringlengths 11 871 | Organism stringlengths 8 73 | Keywords stringlengths 1 810 | Sequence 10 stringlengths 5 10 | Sequence stringlengths 5 1.02k | Combined stringlengths 136 3.91k |
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heme catabolic process monoatomic ion transport organic anion transport sodium-independent organic anion transport transmembrane transport transport across blood-brain barrier xenobiotic metabolic process | apical plasma membrane; basal plasma membrane; basolateral plasma membrane; plasma membrane | organic anion transmembrane transporter activity prostaglandin transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity transmembrane transporter activity | Homo sapiens | Alternative promoter usage Alternative splicing Cell membrane Disulfide bond Glycoprotein Ion transport Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport | MGPRIGPAGE | MGPRIGPAGEVPQVPDKETKATMGTENTPGGKASPDPQDVRPSVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKASLCLPTTSAPASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGITHQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCVVEGNPVLAGSCDSTCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGSVICFALVLAVLRQQDKEARTKESRSSPAVEQQLLVSGPGKKPEDSRV | heme catabolic process monoatomic ion transport organic anion transport sodium-independent organic anion transport transmembrane transport transport across blood-brain barrier xenobiotic metabolic process apical plasma membrane; basal plasma membrane; basolateral plasma membrane; plasma membrane organic anion transmembrane transporter activity prostaglandin transmembrane transporter activity sodium-independent organic anion transmembrane transporter activity transmembrane transporter activity Homo sapiens Alternative promoter usage Alternative splicing Cell membrane Disulfide bond Glycoprotein Ion transport Membrane Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport MGPRIGPAGE MGPRIGPAGEVPQVPDKETKATMGTENTPGGKASPDPQDVRPSVFHNIKLFVLCHSLLQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNEVGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEPYRYDNTSPEDMPQDFKASLCLPTTSAPASAPSNGNCSSYTETQHLSVVGIMFVAQTLLGVGGVPIQPFGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWVGAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAVTDSPARKGKDSPSKQSPGESTKKQDGLVQIAPNLTVIQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSMAAGMATFLPKFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPLFFIGCSSHQIAGITHQTSAHPGLELSPSCMEACSCPLDGFNPVCDPSTRVEYITPCHAGCSSWVVQDALDNSQVFYTNCSCVVEGNPVLAGSCDSTCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPVIHGSAIDTTCVHWALSCGRRAVCRYYNNDLLRNRFIGLQFFFKTGSVICFALVLAVLRQQDKEARTKESRSSPAVEQQLLVSGPGKKPEDSRV |
aggresome assembly negative regulation of centriole replication negative regulation of gene expression, epigenetic negative regulation of NF-kappaB transcription factor activity negative regulation of transcription by RNA polymerase II positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein autoubiquitination protein import into peroxisome matrix protein monoubiquitination protein stabilization | aggresome; chromosome; cytoplasm; cytosol; perinuclear region of cytoplasm; peroxisomal membrane; peroxisome | chromatin binding histone H2AK119 ubiquitin ligase activity protein homodimerization activity transcription coactivator activity tumor necrosis factor receptor binding ubiquitin protein ligase activity ubiquitin protein ligase binding ubiquitin-protein transferase activity zinc ion binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Chromosome Coiled coil Cytoplasm Dwarfism Membrane Metal-binding Peroxisome Phosphoprotein Proto-oncogene Reference proteome Repressor Transcription Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger | MDEQSVESIA | MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKSSEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYRVEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVRSPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQNDDALETRAKKSACSDMLLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLVYEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYNNMELEEGELMEDAAAAGPAGSSHGYVGSSSRISRRTHLCSAATSSLLDIDPLILIHLLDLKDRSSIENLWGLQPRPPASLLQPTASYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTLSEIKSSSAASGDMQTSLFSADQAALAACGTENSGRLQDLGMELLAKSSVANCYIRNSTNKKSNSPKPARSSVAGSLSLRRAVDPGENSRSKGDCQTLSEGSPGSSQSGSRHSSPRALIHGSIGDILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMVTLGANAKGGHLEGLQMTDLENNSETGELQPVLPEGASAAPEEGMSSDSDIECDTENEEQEEHTSVGGFHDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDENSGR | aggresome assembly negative regulation of centriole replication negative regulation of gene expression, epigenetic negative regulation of NF-kappaB transcription factor activity negative regulation of transcription by RNA polymerase II positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein autoubiquitination protein import into peroxisome matrix protein monoubiquitination protein stabilization aggresome; chromosome; cytoplasm; cytosol; perinuclear region of cytoplasm; peroxisomal membrane; peroxisome chromatin binding histone H2AK119 ubiquitin ligase activity protein homodimerization activity transcription coactivator activity tumor necrosis factor receptor binding ubiquitin protein ligase activity ubiquitin protein ligase binding ubiquitin-protein transferase activity zinc ion binding Homo sapiens 3D-structure Acetylation Alternative splicing Chromosome Coiled coil Cytoplasm Dwarfism Membrane Metal-binding Peroxisome Phosphoprotein Proto-oncogene Reference proteome Repressor Transcription Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger MDEQSVESIA MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISKSSEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYRVEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVRSPTFFQKSRDQHWYITQLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQNDDALETRAKKSACSDMLLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLVYEDEVNQLDGSSSSASSTATSNTEENDIDEETMSGENDVEYNNMELEEGELMEDAAAAGPAGSSHGYVGSSSRISRRTHLCSAATSSLLDIDPLILIHLLDLKDRSSIENLWGLQPRPPASLLQPTASYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTLSEIKSSSAASGDMQTSLFSADQAALAACGTENSGRLQDLGMELLAKSSVANCYIRNSTNKKSNSPKPARSSVAGSLSLRRAVDPGENSRSKGDCQTLSEGSPGSSQSGSRHSSPRALIHGSIGDILPKTEDRQCKALDSDAVVVAVFSGLPAVEKRRKMVTLGANAKGGHLEGLQMTDLENNSETGELQPVLPEGASAAPEEGMSSDSDIECDTENEEQEEHTSVGGFHDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDENSGR |
clathrin-dependent endocytosis intracellular protein transport postsynaptic neurotransmitter receptor internalization vesicle-mediated transport | AP-2 adaptor complex; clathrin-coated endocytic vesicle; clathrin-coated endocytic vesicle membrane; cytoplasmic side of plasma membrane; cytoplasmic vesicle; cytosol; endocytic vesicle membrane; endolysosome membrane; ficolin-1-rich granule membrane; plasma membrane; postsynapse; secretory granule membrane | clathrin adaptor activity disordered domain specific binding lipid binding protein kinase binding | Homo sapiens | Alternative splicing Cell membrane Coated pit Endocytosis Lipid-binding Membrane Protein transport Reference proteome Transport | MPAVSKGDGM | MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALLLSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLEDTKRDRSVDVNGGPEPAPASTSAVSTPSPSADLLGLGAAPPAPAGPPPSSGGSGLLVDVFSDSASVVAPLAPGSEDNFARFVCKNNGVLFENQLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLICSDDLQPNLNLQTKPVDPTVEGGAQVQQVVNIECVSDFTEAPVLNIQFRYGGTFQNVSVQLPITLNKFFQPTEMASQDFFQRWKQLSNPQQEVQNIFKAKHPMDTEVTKAKIIGFGSALLEEVDPNPANFVGAGIIHTKTTQIGCLLRLEPNLQAQMYRLTLRTSKEAVSQRLCELLSAQF | clathrin-dependent endocytosis intracellular protein transport postsynaptic neurotransmitter receptor internalization vesicle-mediated transport AP-2 adaptor complex; clathrin-coated endocytic vesicle; clathrin-coated endocytic vesicle membrane; cytoplasmic side of plasma membrane; cytoplasmic vesicle; cytosol; endocytic vesicle membrane; endolysosome membrane; ficolin-1-rich granule membrane; plasma membrane; postsynapse; secretory granule membrane clathrin adaptor activity disordered domain specific binding lipid binding protein kinase binding Homo sapiens Alternative splicing Cell membrane Coated pit Endocytosis Lipid-binding Membrane Protein transport Reference proteome Transport MPAVSKGDGM MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQKNPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCYPPPDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALLLSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSILAKLKKKKGPSTVTDLEDTKRDRSVDVNGGPEPAPASTSAVSTPSPSADLLGLGAAPPAPAGPPPSSGGSGLLVDVFSDSASVVAPLAPGSEDNFARFVCKNNGVLFENQLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLICSDDLQPNLNLQTKPVDPTVEGGAQVQQVVNIECVSDFTEAPVLNIQFRYGGTFQNVSVQLPITLNKFFQPTEMASQDFFQRWKQLSNPQQEVQNIFKAKHPMDTEVTKAKIIGFGSALLEEVDPNPANFVGAGIIHTKTTQIGCLLRLEPNLQAQMYRLTLRTSKEAVSQRLCELLSAQF |
cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules neurotransmitter receptor transport to postsynaptic membrane positive regulation of synapse assembly positive regulation of synaptic transmission regulation of cell growth regulation of synapse maturation vesicle-mediated transport in synapse | cell surface; endoplasmic reticulum membrane; extracellular region; glutamatergic synapse; Golgi membrane; neuron projection; nucleus; postsynaptic density; postsynaptic endosome; postsynaptic membrane | amyloid-beta binding calcium ion binding kinesin binding X11-like protein binding | Homo sapiens | Alternative splicing Calcium Cell adhesion Cell membrane Cell projection Direct protein sequencing Endoplasmic reticulum Glycoprotein Golgi apparatus Membrane Nucleus Postsynaptic cell membrane Reference proteome Repeat Signal Synapse Transmembrane Transmembrane helix | MLRRPAPALA | MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSDQVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHEPFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGVHHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQLEWDDSTLSY | cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules neurotransmitter receptor transport to postsynaptic membrane positive regulation of synapse assembly positive regulation of synaptic transmission regulation of cell growth regulation of synapse maturation vesicle-mediated transport in synapse cell surface; endoplasmic reticulum membrane; extracellular region; glutamatergic synapse; Golgi membrane; neuron projection; nucleus; postsynaptic density; postsynaptic endosome; postsynaptic membrane amyloid-beta binding calcium ion binding kinesin binding X11-like protein binding Homo sapiens Alternative splicing Calcium Cell adhesion Cell membrane Cell projection Direct protein sequencing Endoplasmic reticulum Glycoprotein Golgi apparatus Membrane Nucleus Postsynaptic cell membrane Reference proteome Repeat Signal Synapse Transmembrane Transmembrane helix MLRRPAPALA MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSDQVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHEPFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGVHHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQLEWDDSTLSY |
negative regulation of synapse maturation positive regulation of stress fiber assembly regulation of catalytic activity regulation of postsynapse assembly regulation of small GTPase mediated signal transduction retina vasculature morphogenesis in camera-type eye | cytoplasm; cytosol; dendrite; glutamatergic synapse; postsynapse | GTPase activator activity guanyl-nucleotide exchange factor activity | Homo sapiens | Cell projection GTPase activation Guanine-nucleotide releasing factor Phosphoprotein Reference proteome Ubl conjugation | MSAQSLPAAT | MSAQSLPAATPPTQKPPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRSASPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEGRAQDADAPEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLELRWVPVGGYEEVPRVPRRASPLRTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFGDPPQPDLDLLSEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLKEQNWELPLQDEPLYQTYRAAVLSEELWGVGEDGSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPTHRLLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSLESRAAPKHLHKTPEGWLKGLPGAFPAQLVCEVTGEHERRRHLRQNQRLLEAVGSSSGTPNAPPP | negative regulation of synapse maturation positive regulation of stress fiber assembly regulation of catalytic activity regulation of postsynapse assembly regulation of small GTPase mediated signal transduction retina vasculature morphogenesis in camera-type eye cytoplasm; cytosol; dendrite; glutamatergic synapse; postsynapse GTPase activator activity guanyl-nucleotide exchange factor activity Homo sapiens Cell projection GTPase activation Guanine-nucleotide releasing factor Phosphoprotein Reference proteome Ubl conjugation MSAQSLPAAT MSAQSLPAATPPTQKPPRIIRPRPPSRSRAAQSPGPPHNGSSPQELPRNSNDAPTPMCTPIFWEPPAASLKPPALLPPSASRASLDSQTSPDSPSSTPTPSPVSRRSASPEPAPRSPVPPPKPSGSPCTPLLPMAGVLAQNGSASAPGTVRRLAGRFEGGAEGRAQDADAPEPGLQARADVNGEREAPLTGSGSQENGAPDAGLACPPCCPCVCHTTRPGLELRWVPVGGYEEVPRVPRRASPLRTSRSRPHPPSIGHPAVVLTSYRSTAERKLLPLLKPPKPTRVRQDATIFGDPPQPDLDLLSEDGIQTGDSPDEAPQNTPPATVEGREEEGLEVLKEQNWELPLQDEPLYQTYRAAVLSEELWGVGEDGSPSPANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLATLLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILRQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLEFQGELTELGCRRGGVLFASRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPTHRLLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSESSAPAKTEGRSLESRAAPKHLHKTPEGWLKGLPGAFPAQLVCEVTGEHERRRHLRQNQRLLEAVGSSSGTPNAPPP |
activation of innate immune response heart development innate immune response negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of transcription elongation by RNA polymerase II negative regulation of viral transcription positive regulation of signal transduction by p53 class mediator | 7SK snRNP; cytoplasm; intracellular membrane-bounded organelle; nucleoplasm; nucleus | 7SK snRNA binding cyclin-dependent protein serine/threonine kinase inhibitor activity identical protein binding P-TEFb complex binding protein kinase inhibitor activity snRNA binding | Homo sapiens | 3D-structure Coiled coil Cytoplasm Immunity Innate immunity Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation | MAEPFLSEYQ | MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQLGGRPGPEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDSSAGGDFPPPAEVEPTPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYSKRAAAKSDDTSDDDFMEEGGEEDGGSDGMGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSRMEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD | activation of innate immune response heart development innate immune response negative regulation of cyclin-dependent protein serine/threonine kinase activity negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of transcription elongation by RNA polymerase II negative regulation of viral transcription positive regulation of signal transduction by p53 class mediator 7SK snRNP; cytoplasm; intracellular membrane-bounded organelle; nucleoplasm; nucleus 7SK snRNA binding cyclin-dependent protein serine/threonine kinase inhibitor activity identical protein binding P-TEFb complex binding protein kinase inhibitor activity snRNA binding Homo sapiens 3D-structure Coiled coil Cytoplasm Immunity Innate immunity Nucleus Phosphoprotein Reference proteome Repressor Transcription Transcription regulation MAEPFLSEYQ MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQLGGRPGPEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDSSAGGDFPPPAEVEPTPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYSKRAAAKSDDTSDDDFMEEGGEEDGGSDGMGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSRMEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD |
negative regulation of transcription by RNA polymerase II negative regulation of Wnt signaling pathway positive regulation of transcription by RNA polymerase II proacrosomal vesicle fusion regulation of transcription by RNA polymerase II response to corticosteroid spermatid development | chromatin; chromocenter; cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleoplasm; nucleus | beta-catenin binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | 3D-structure Activator Alternative splicing Cytoplasm DNA-binding Nucleus Reference proteome Repressor Transcription Transcription regulation | MERARPEPPP | MERARPEPPPQPRPLRPAPPPLPVEGTSFWAAAMEPPPSSPTLSAAASATLASSCGEAVASGLQPAVRRLLQVKPEQVLLLPQPQAQNEEAAASSAQARLLQFRPDLRLLQPPTASDGATSRPELHPVQPLALHVKAKKQKLGPSLDQSVGPRGAVETGPRASRVVKLEGPGPALGYFRGDEKGKLEAEEVMRDSMQGGAGKSPAAIREGVIKTEEPERLLEDCRLGAEPASNGLVHGSAEVILAPTSGAFGPHQQDLRIPLTLHTVPPGARIQFQGAPPSELIRLTKVPLTPVPTKMQSLLEPSVKIETKDVPLTVLPSDAGIPDTPFSKDRNGHVKRPMNAFMVWARIHRPALAKANPAANNAEISVQLGLEWNKLSEEQKKPYYDEAQKIKEKHREEFPGWVYQPRPGKRKRFPLSVSNVFSGTTQNIISTNPTTVYPYRSPTYSVVIPSLQNPITHPVGETSPAIQLPTPAVQSPSPVTLFQPSVSSAAQVAVQDPSLPVYPALPPQRFTGPSQTDTHQLHSEATHTVKQPTPVSLESANRISSSASTAHARFATSTIQPPREYSSVSPCPRSAPIPQASPIPHPHVYQPPPLGHPATLFGTPPRFSFHHPYFLPGPHYFPSSTCPYSRPPFGYGNFPSSMPECLSYYEDRYPKHEGIFSTLNRDYSFRDYSSECTHSENSRSCENMNGTSYYNSHSHSGEENLNPVPQLDIGTLENVFTAPTSTPSSIQQVNVTDSDEEEEEKVLRDL | negative regulation of transcription by RNA polymerase II negative regulation of Wnt signaling pathway positive regulation of transcription by RNA polymerase II proacrosomal vesicle fusion regulation of transcription by RNA polymerase II response to corticosteroid spermatid development chromatin; chromocenter; cytoplasm; cytosol; intracellular membrane-bounded organelle; nucleoplasm; nucleus beta-catenin binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens 3D-structure Activator Alternative splicing Cytoplasm DNA-binding Nucleus Reference proteome Repressor Transcription Transcription regulation MERARPEPPP MERARPEPPPQPRPLRPAPPPLPVEGTSFWAAAMEPPPSSPTLSAAASATLASSCGEAVASGLQPAVRRLLQVKPEQVLLLPQPQAQNEEAAASSAQARLLQFRPDLRLLQPPTASDGATSRPELHPVQPLALHVKAKKQKLGPSLDQSVGPRGAVETGPRASRVVKLEGPGPALGYFRGDEKGKLEAEEVMRDSMQGGAGKSPAAIREGVIKTEEPERLLEDCRLGAEPASNGLVHGSAEVILAPTSGAFGPHQQDLRIPLTLHTVPPGARIQFQGAPPSELIRLTKVPLTPVPTKMQSLLEPSVKIETKDVPLTVLPSDAGIPDTPFSKDRNGHVKRPMNAFMVWARIHRPALAKANPAANNAEISVQLGLEWNKLSEEQKKPYYDEAQKIKEKHREEFPGWVYQPRPGKRKRFPLSVSNVFSGTTQNIISTNPTTVYPYRSPTYSVVIPSLQNPITHPVGETSPAIQLPTPAVQSPSPVTLFQPSVSSAAQVAVQDPSLPVYPALPPQRFTGPSQTDTHQLHSEATHTVKQPTPVSLESANRISSSASTAHARFATSTIQPPREYSSVSPCPRSAPIPQASPIPHPHVYQPPPLGHPATLFGTPPRFSFHHPYFLPGPHYFPSSTCPYSRPPFGYGNFPSSMPECLSYYEDRYPKHEGIFSTLNRDYSFRDYSSECTHSENSRSCENMNGTSYYNSHSHSGEENLNPVPQLDIGTLENVFTAPTSTPSSIQQVNVTDSDEEEEEKVLRDL |
dCMP catabolic process nucleoside metabolic process UMP salvage uridine catabolic process uridine metabolic process | cytosol; type III intermediate filament | deoxyuridine phosphorylase activity identical protein binding uridine phosphorylase activity | Homo sapiens | 3D-structure Alternative splicing Disulfide bond Glycosyltransferase Redox-active center Reference proteome Transferase | MASVIPASNR | MASVIPASNRSMRSDRNTYVGKRFVHVKNPYLDLMDEDILYHLDLGTKTHNLPAMFGDVKFVCVGGSPNRMKAFALFMHKELGFEEAEEDIKDICAGTDRYCMYKTGPVLAISHGMGIPSISIMLHELIKLLHHARCCDVTIIRIGTSGGIGIAPGTVVITDIAVDSFFKPRFEQVILDNIVTRSTELDKELSEELFNCSKEIPNFPTLVGHTMCTYDFYEGQGRLDGALCSFSREKKLDYLKRAFKAGVRNIEMESTVFAAMCGLCGLKAAVVCVTLLDRLDCDQINLPHDVLVEYQQRPQLLISNFIRRRLGLCD | dCMP catabolic process nucleoside metabolic process UMP salvage uridine catabolic process uridine metabolic process cytosol; type III intermediate filament deoxyuridine phosphorylase activity identical protein binding uridine phosphorylase activity Homo sapiens 3D-structure Alternative splicing Disulfide bond Glycosyltransferase Redox-active center Reference proteome Transferase MASVIPASNR MASVIPASNRSMRSDRNTYVGKRFVHVKNPYLDLMDEDILYHLDLGTKTHNLPAMFGDVKFVCVGGSPNRMKAFALFMHKELGFEEAEEDIKDICAGTDRYCMYKTGPVLAISHGMGIPSISIMLHELIKLLHHARCCDVTIIRIGTSGGIGIAPGTVVITDIAVDSFFKPRFEQVILDNIVTRSTELDKELSEELFNCSKEIPNFPTLVGHTMCTYDFYEGQGRLDGALCSFSREKKLDYLKRAFKAGVRNIEMESTVFAAMCGLCGLKAAVVCVTLLDRLDCDQINLPHDVLVEYQQRPQLLISNFIRRRLGLCD |
detection of chemical stimulus involved in sensory perception of smell positive regulation of cytokinesis regulation of actin cytoskeleton organization | cleavage furrow; Flemming body; mitotic spindle midzone; mitotic spindle pole; recycling endosome | G protein-coupled receptor activity odorant binding olfactory receptor activity | Homo sapiens | Cell membrane G-protein coupled receptor Glycoprotein Membrane Olfaction Receptor Reference proteome Sensory transduction Transducer Transmembrane Transmembrane helix | MGDNITSIRE | MGDNITSIREFLLLGFPVGPRIQMLLFGLFSLFYVFTLLGNGTILGLISLDSRLHAPMYFFLSHLAVVDIAYACNTVPRMLVNLLHPAKPISFAGRMMQTFLFSTFAVTECLLLVVMSYDLYVAICHPLRYLAIMTWRVCITLAVTSWTTGVLLSLIHLVLLLPLPFCRPQKIYHFFCEILAVLKLACADTHINENMVLAGAISGLVGPLSTIVVSYMCILCAILQIQSREVQRKAFRTCFSHLCVIGLVYGTAIIMYVGPRYGNPKEQKKYLLLFHSLFNPMLNPLICSLRNSEVKNTLKRVLGVERAL | detection of chemical stimulus involved in sensory perception of smell positive regulation of cytokinesis regulation of actin cytoskeleton organization cleavage furrow; Flemming body; mitotic spindle midzone; mitotic spindle pole; recycling endosome G protein-coupled receptor activity odorant binding olfactory receptor activity Homo sapiens Cell membrane G-protein coupled receptor Glycoprotein Membrane Olfaction Receptor Reference proteome Sensory transduction Transducer Transmembrane Transmembrane helix MGDNITSIRE MGDNITSIREFLLLGFPVGPRIQMLLFGLFSLFYVFTLLGNGTILGLISLDSRLHAPMYFFLSHLAVVDIAYACNTVPRMLVNLLHPAKPISFAGRMMQTFLFSTFAVTECLLLVVMSYDLYVAICHPLRYLAIMTWRVCITLAVTSWTTGVLLSLIHLVLLLPLPFCRPQKIYHFFCEILAVLKLACADTHINENMVLAGAISGLVGPLSTIVVSYMCILCAILQIQSREVQRKAFRTCFSHLCVIGLVYGTAIIMYVGPRYGNPKEQKKYLLLFHSLFNPMLNPLICSLRNSEVKNTLKRVLGVERAL |
cell-cell adhesion cell-cell junction organization establishment of endothelial intestinal barrier maintenance of blood-brain barrier positive regulation of blood-brain barrier permeability protein localization to cell-cell junction | bicellular tight junction; cell junction; nucleoplasm; nucleus; plasma membrane | cell adhesion molecule binding | Homo sapiens | 3D-structure Alternative splicing Cell junction Cell membrane Membrane Nucleus Phosphoprotein Reference proteome Repeat SH3 domain Tight junction | MEELTIWEQH | MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEDISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAETVSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIWTAEDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDYETDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADESQSPRDRGRISAHQGAQVDSRHPQGQWRQDSMRTYEREALKKKFMRVHDAESSDEDGYDWGPATDL | cell-cell adhesion cell-cell junction organization establishment of endothelial intestinal barrier maintenance of blood-brain barrier positive regulation of blood-brain barrier permeability protein localization to cell-cell junction bicellular tight junction; cell junction; nucleoplasm; nucleus; plasma membrane cell adhesion molecule binding Homo sapiens 3D-structure Alternative splicing Cell junction Cell membrane Membrane Nucleus Phosphoprotein Reference proteome Repeat SH3 domain Tight junction MEELTIWEQH MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVPGGPAEGRLQTGDHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKASPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSHGRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKHITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFLVNIPPAVSDSDSSPLEDISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRLRRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSIGLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLLGLPPGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVLDTLHPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVILGPVADIAMQKLTAEMPDQFEIAETVSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTWYQELKAIIREQQTRPIWTAEDQLDGSLEDNLDLPHHGLADSSADLSCDSRVNSDYETDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADESQSPRDRGRISAHQGAQVDSRHPQGQWRQDSMRTYEREALKKKFMRVHDAESSDEDGYDWGPATDL |
amine metabolic process methylation response to toxic substance | cytosol | amine N-methyltransferase activity N-methyltransferase activity S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity thioether S-methyltransferase activity | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Detoxification Methyltransferase Reference proteome S-adenosyl-L-methionine Transferase | MKGGFTGGDE | MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAALCNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEEVEQAVLDAGFDIEQLLHSPQSYSVTNAANNGVCFIVARKKPGP | amine metabolic process methylation response to toxic substance cytosol amine N-methyltransferase activity N-methyltransferase activity S-adenosyl-L-methionine:beta-alanine N-methyltransferase activity thioether S-methyltransferase activity Homo sapiens 3D-structure Alternative splicing Cytoplasm Detoxification Methyltransferase Reference proteome S-adenosyl-L-methionine Transferase MKGGFTGGDE MKGGFTGGDEYQKHFLPRDYLATYYSFDGSPSPEAEMLKFNLECLHKTFGPGGLQGDTLIDIGSGPTIYQVLAACDSFQDITLSDFTDRNREELEKWLKKEPGAYDWTPAVKFACELEGNSGRWEEKEEKLRAAVKRVLKCDVHLGNPLAPAVLPLADCVLTLLAMECACCSLDAYRAALCNLASLLKPGGHLVTTVTLRLPSYMVGKREFSCVALEKEEVEQAVLDAGFDIEQLLHSPQSYSVTNAANNGVCFIVARKKPGP |
signal transduction | plasma membrane | GDP binding GTP binding GTPase activity | Homo sapiens | 3D-structure Cell membrane GTP-binding Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Reference proteome | MPEQSNDYRV | MPEQSNDYRVVVFGAGGVGKSSLVLRFVKGTFRDTYIPTIEDTYRQVISCDKSVCTLQITDTTGSHQFPAMQRLSISKGHAFILVFSVTSKQSLEELGPIYKLIVQIKGSVEDIPVMLVGNKCDETQREVDTREAQAVAQEWKCAFMETSAKMNYNVKELFQELLTLETRRNMSLNIDGKRSGKQKRTDRVKGKCTLM | signal transduction plasma membrane GDP binding GTP binding GTPase activity Homo sapiens 3D-structure Cell membrane GTP-binding Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Reference proteome MPEQSNDYRV MPEQSNDYRVVVFGAGGVGKSSLVLRFVKGTFRDTYIPTIEDTYRQVISCDKSVCTLQITDTTGSHQFPAMQRLSISKGHAFILVFSVTSKQSLEELGPIYKLIVQIKGSVEDIPVMLVGNKCDETQREVDTREAQAVAQEWKCAFMETSAKMNYNVKELFQELLTLETRRNMSLNIDGKRSGKQKRTDRVKGKCTLM |
tRNA 5'-leader removal | multimeric ribonuclease P complex; nucleolus; nucleoplasm | ribonuclease P activity ribonuclease P RNA binding | Homo sapiens | 3D-structure Direct protein sequencing Nucleus Reference proteome RNA-binding tRNA processing | MPAPAATYER | MPAPAATYERVVYKNPSEYHYMKVCLEFQDCGVGLNAAQFKQLLISAVKDLFGEVDAALPLDILTYEEKTLSAILRICSSGLVKLWSSLTLLGSYKGKKCAFRVIQVSPFLLALSGNSRELVLD | tRNA 5'-leader removal multimeric ribonuclease P complex; nucleolus; nucleoplasm ribonuclease P activity ribonuclease P RNA binding Homo sapiens 3D-structure Direct protein sequencing Nucleus Reference proteome RNA-binding tRNA processing MPAPAATYER MPAPAATYERVVYKNPSEYHYMKVCLEFQDCGVGLNAAQFKQLLISAVKDLFGEVDAALPLDILTYEEKTLSAILRICSSGLVKLWSSLTLLGSYKGKKCAFRVIQVSPFLLALSGNSRELVLD |
cell division G2/MI transition of meiotic cell cycle in utero embryonic development mitotic cell cycle phase transition regulation of growth spindle assembly involved in female meiosis I T cell homeostasis thymus development | centrosome; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; membrane; microtubule cytoskeleton; nucleus | cadherin binding cyclin-dependent protein serine/threonine kinase regulator activity | Homo sapiens | Cell cycle Cell division Cyclin Mitosis Phosphoprotein Reference proteome | MALLRRPTVS | MALLRRPTVSSDLENIDTGVNSKVKSHVTIRRTVLEEIGNRVTTRAAQVAKKAQNTKVPVQPTKTTNVNKQLKPTASVKPVQMEKLAPKGPSPTPEDVSMKEENLCQAFSDALLCKIEDIDNEDWENPQLCSDYVKDIYQYLRQLEVLQSINPHFLDGRDINGRMRAILVDWLVQVHSKFRLLQETLYMCVGIMDRFLQVQPVSRKKLQLVGITALLLASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFELGRPLPLHFLRRASKAGEVDVEQHTLAKYLMELTLIDYDMVHYHPSKVAAAASCLSQKVLGQGKWNLKQQYYTGYTENEVLEVMQHMAKNVVKVNENLTKFIAIKNKYASSKLLKISMIPQLNSKAVKDLASPLIGRS | cell division G2/MI transition of meiotic cell cycle in utero embryonic development mitotic cell cycle phase transition regulation of growth spindle assembly involved in female meiosis I T cell homeostasis thymus development centrosome; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; membrane; microtubule cytoskeleton; nucleus cadherin binding cyclin-dependent protein serine/threonine kinase regulator activity Homo sapiens Cell cycle Cell division Cyclin Mitosis Phosphoprotein Reference proteome MALLRRPTVS MALLRRPTVSSDLENIDTGVNSKVKSHVTIRRTVLEEIGNRVTTRAAQVAKKAQNTKVPVQPTKTTNVNKQLKPTASVKPVQMEKLAPKGPSPTPEDVSMKEENLCQAFSDALLCKIEDIDNEDWENPQLCSDYVKDIYQYLRQLEVLQSINPHFLDGRDINGRMRAILVDWLVQVHSKFRLLQETLYMCVGIMDRFLQVQPVSRKKLQLVGITALLLASKYEEMFSPNIEDFVYITDNAYTSSQIREMETLILKELKFELGRPLPLHFLRRASKAGEVDVEQHTLAKYLMELTLIDYDMVHYHPSKVAAAASCLSQKVLGQGKWNLKQQYYTGYTENEVLEVMQHMAKNVVKVNENLTKFIAIKNKYASSKLLKISMIPQLNSKAVKDLASPLIGRS |
cardiac ventricle development cellular response to hypoxia cochlea development G protein-coupled receptor signaling pathway memory negative regulation of cardiac muscle cell proliferation negative regulation of DNA biosynthetic process positive regulation of cellular response to hypoxia potassium ion transmembrane transport response to axon injury response to mechanical stimulus stabilization of membrane potential | apical plasma membrane; astrocyte projection; calyx of Held; cell surface; endoplasmic reticulum; endoplasmic reticulum membrane; neuronal cell body; plasma membrane; voltage-gated potassium channel complex | outward rectifier potassium channel activity potassium channel inhibitor activity potassium ion leak channel activity | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disulfide bond Endoplasmic reticulum Glycoprotein Ion channel Ion transport Membrane Phosphoprotein Potassium Potassium channel Potassium transport Reference proteome Transmembrane Transmembrane helix Transport | MLPSASRERP | MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSIKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIAVIENIK | cardiac ventricle development cellular response to hypoxia cochlea development G protein-coupled receptor signaling pathway memory negative regulation of cardiac muscle cell proliferation negative regulation of DNA biosynthetic process positive regulation of cellular response to hypoxia potassium ion transmembrane transport response to axon injury response to mechanical stimulus stabilization of membrane potential apical plasma membrane; astrocyte projection; calyx of Held; cell surface; endoplasmic reticulum; endoplasmic reticulum membrane; neuronal cell body; plasma membrane; voltage-gated potassium channel complex outward rectifier potassium channel activity potassium channel inhibitor activity potassium ion leak channel activity Homo sapiens 3D-structure Alternative splicing Cell membrane Disulfide bond Endoplasmic reticulum Glycoprotein Ion channel Ion transport Membrane Phosphoprotein Potassium Potassium channel Potassium transport Reference proteome Transmembrane Transmembrane helix Transport MLPSASRERP MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSIKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIAVIENIK |
double-strand break repair double-strand break repair via homologous recombination fertilization male meiosis I meiotic cell cycle meiotic sister chromatid cohesion oocyte maturation reciprocal meiotic recombination seminiferous tubule development sister chromatid cohesion spermatid development spermatogenesis synaptonemal complex assembly | cohesin complex; kinetochore; lateral element; male germ cell nucleus; meiotic cohesin complex; nucleus | chromatin binding | Homo sapiens | Alternative splicing Centromere Chromosome Chromosome partition Meiosis Nucleus Phosphoprotein Reference proteome | MFYYPNVLQR | MFYYPNVLQRHTGCFATIWLAATRGSRLVKREYLRVNVVKTCEEILNYVLVRVQPPQPGLPRPRFSLYLSAQLQIGVIRVYSQQCQYLVEDIQHILERLHRAQLQIRIDMETELPSLLLPNHLAMMETLEDAPDPFFGMMSVDPRLPSPFDIPQIRHLLEAAIPERVEEIPPEVPTEPREPERIPVTVLPPEAITILEAEPIRMLEIEGERELPEVSRRELDLLIAEEEEAILLEIPRLPPPAPAEVEGIGEALGPEELRLTGWEPGALLMEVTPPEELRLPAPPSPERRPPVPPPPRRRRRRRLLFWDKETQISPEKFQEQLQTRAHCWECPMVQPPERTIRGPAELFRTPTLSGWLPPELLGLWTHCAQPPPKALRRELPEEAAAEEERRKIEVPSEIEVPREALEPSVPLMVSLEISLEAAEEEKSRISLIPPEERWAWPEVEAPEAPALPVVPELPEVPMEMPLVLPPELELLSLEAVHRAVALELQANREPDFSSLVSPLSPRRMAARVFYLLLVLSAQQILHVKQEKPYGRLLIQPGPRFH | double-strand break repair double-strand break repair via homologous recombination fertilization male meiosis I meiotic cell cycle meiotic sister chromatid cohesion oocyte maturation reciprocal meiotic recombination seminiferous tubule development sister chromatid cohesion spermatid development spermatogenesis synaptonemal complex assembly cohesin complex; kinetochore; lateral element; male germ cell nucleus; meiotic cohesin complex; nucleus chromatin binding Homo sapiens Alternative splicing Centromere Chromosome Chromosome partition Meiosis Nucleus Phosphoprotein Reference proteome MFYYPNVLQR MFYYPNVLQRHTGCFATIWLAATRGSRLVKREYLRVNVVKTCEEILNYVLVRVQPPQPGLPRPRFSLYLSAQLQIGVIRVYSQQCQYLVEDIQHILERLHRAQLQIRIDMETELPSLLLPNHLAMMETLEDAPDPFFGMMSVDPRLPSPFDIPQIRHLLEAAIPERVEEIPPEVPTEPREPERIPVTVLPPEAITILEAEPIRMLEIEGERELPEVSRRELDLLIAEEEEAILLEIPRLPPPAPAEVEGIGEALGPEELRLTGWEPGALLMEVTPPEELRLPAPPSPERRPPVPPPPRRRRRRRLLFWDKETQISPEKFQEQLQTRAHCWECPMVQPPERTIRGPAELFRTPTLSGWLPPELLGLWTHCAQPPPKALRRELPEEAAAEEERRKIEVPSEIEVPREALEPSVPLMVSLEISLEAAEEEKSRISLIPPEERWAWPEVEAPEAPALPVVPELPEVPMEMPLVLPPELELLSLEAVHRAVALELQANREPDFSSLVSPLSPRRMAARVFYLLLVLSAQQILHVKQEKPYGRLLIQPGPRFH |
astrocyte differentiation brain development cell differentiation digestive tract development negative regulation of neuron differentiation neuroendocrine cell differentiation neuron fate specification oligodendrocyte development optic nerve development pancreatic A cell fate commitment pancreatic PP cell fate commitment positive regulation of epithelial cell differentiation positive regulation of gene expression positive regulation of neuron differentiation positive regulation of oligodendrocyte differentiation regulation of transcription by RNA polymerase II response to glucose response to progesterone smoothened signaling pathway spinal cord motor neuron differentiation spinal cord oligodendrocyte cell fate specification type B pancreatic cell development type B pancreatic cell fate commitment ventral spinal cord interneuron fate determination | chromatin; nucleoplasm; nucleus | cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | Activator Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation | MSLTNTKTGF | MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEENEGPEPAKRAGPLGQGALDAVQSLPLKNPFYDSSDNPYTRWLASTEGLQYSLHGLAAGAPPQDSSSKSPEPSADESPDNDKETPGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW | astrocyte differentiation brain development cell differentiation digestive tract development negative regulation of neuron differentiation neuroendocrine cell differentiation neuron fate specification oligodendrocyte development optic nerve development pancreatic A cell fate commitment pancreatic PP cell fate commitment positive regulation of epithelial cell differentiation positive regulation of gene expression positive regulation of neuron differentiation positive regulation of oligodendrocyte differentiation regulation of transcription by RNA polymerase II response to glucose response to progesterone smoothened signaling pathway spinal cord motor neuron differentiation spinal cord oligodendrocyte cell fate specification type B pancreatic cell development type B pancreatic cell fate commitment ventral spinal cord interneuron fate determination chromatin; nucleoplasm; nucleus cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding Homo sapiens Activator Developmental protein DNA-binding Homeobox Nucleus Reference proteome Transcription Transcription regulation MSLTNTKTGF MSLTNTKTGFSVKDILDLPDTNDEEGSVAEGPEEENEGPEPAKRAGPLGQGALDAVQSLPLKNPFYDSSDNPYTRWLASTEGLQYSLHGLAAGAPPQDSSSKSPEPSADESPDNDKETPGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW |
lipid metabolic process negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | chromosome; nuclear body; nucleolus | DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | Alternative splicing DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MATAVEPEDQ | MATAVEPEDQDLWEEEGILMVKLEDDFTCRPESVLQRDDPVLETSHQNFRRFRYQEAASPREALIRLRELCHQWLRPERRTKEQILELLVLEQFLTVLPGELQSWVRGQRPESGEEAVTLVEGLQKQPRRPRRWVTVHVHGQEVLSEETVHLGVEPESPNELQDPVQSSTPEQSPEETTQSPDLGAPAEQRPHQEEELQTLQESEVPVPEDPDLPAERSSGDSEMVALLTALSQGLVTFKDVAVCFSQDQWSDLDPTQKEFYGEYVLEEDCGIVVSLSFPIPRPDEISQVREEEPWVPDIQEPQETQEPEILSFTYTGDRSKDEEECLEQEDLSLEDIHRPVLGEPEIHQTPDWEIVFEDNPGRLNERRFGTNISQVNSFVNLRETTPVHPLLGRHHDCSVCGKSFTCNSHLVRHLRTHTGEKPYKCMECGKSYTRSSHLARHQKVHKMNAPYKYPLNRKNLEETSPVTQAERTPSVEKPYRCDDCGKHFRWTSDLVRHQRTHTGEKPFFCTICGKSFSQKSVLTTHQRIHLGGKPYLCGECGEDFSEHRRYLAHRKTHAAEELYLCSECGRCFTHSAAFAKHLRGHASVRPCRCNECGKSFSRRDHLVRHQRTHTGEKPFTCPTCGKSFSRGYHLIRHQRTHSEKTS | lipid metabolic process negative regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II chromosome; nuclear body; nucleolus DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Homo sapiens Alternative splicing DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger MATAVEPEDQ MATAVEPEDQDLWEEEGILMVKLEDDFTCRPESVLQRDDPVLETSHQNFRRFRYQEAASPREALIRLRELCHQWLRPERRTKEQILELLVLEQFLTVLPGELQSWVRGQRPESGEEAVTLVEGLQKQPRRPRRWVTVHVHGQEVLSEETVHLGVEPESPNELQDPVQSSTPEQSPEETTQSPDLGAPAEQRPHQEEELQTLQESEVPVPEDPDLPAERSSGDSEMVALLTALSQGLVTFKDVAVCFSQDQWSDLDPTQKEFYGEYVLEEDCGIVVSLSFPIPRPDEISQVREEEPWVPDIQEPQETQEPEILSFTYTGDRSKDEEECLEQEDLSLEDIHRPVLGEPEIHQTPDWEIVFEDNPGRLNERRFGTNISQVNSFVNLRETTPVHPLLGRHHDCSVCGKSFTCNSHLVRHLRTHTGEKPYKCMECGKSYTRSSHLARHQKVHKMNAPYKYPLNRKNLEETSPVTQAERTPSVEKPYRCDDCGKHFRWTSDLVRHQRTHTGEKPFFCTICGKSFSQKSVLTTHQRIHLGGKPYLCGECGEDFSEHRRYLAHRKTHAAEELYLCSECGRCFTHSAAFAKHLRGHASVRPCRCNECGKSFSRRDHLVRHQRTHTGEKPFTCPTCGKSFSRGYHLIRHQRTHSEKTS |
actin cytoskeleton organization adenylate cyclase-activating G protein-coupled receptor signaling pathway excitatory postsynaptic potential filopodium assembly G protein-coupled receptor signaling pathway negative regulation of excitatory postsynaptic potential positive regulation of cell population proliferation positive regulation of establishment of endothelial barrier positive regulation of peptidyl-threonine phosphorylation regulation of metabolic process sphingosine-1-phosphate receptor signaling pathway | cytoplasm; plasma membrane; postsynapse | G protein-coupled peptide receptor activity G protein-coupled receptor activity G protein-coupled receptor binding integrin binding lipid binding sphingosine-1-phosphate receptor activity | Homo sapiens | 3D-structure Cell membrane Deafness Disease variant G-protein coupled receptor Glycoprotein Lipoprotein Membrane Non-syndromic deafness Palmitate Receptor Reference proteome Transducer Transmembrane Transmembrane helix | MGSLYSEYLN | MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV | actin cytoskeleton organization adenylate cyclase-activating G protein-coupled receptor signaling pathway excitatory postsynaptic potential filopodium assembly G protein-coupled receptor signaling pathway negative regulation of excitatory postsynaptic potential positive regulation of cell population proliferation positive regulation of establishment of endothelial barrier positive regulation of peptidyl-threonine phosphorylation regulation of metabolic process sphingosine-1-phosphate receptor signaling pathway cytoplasm; plasma membrane; postsynapse G protein-coupled peptide receptor activity G protein-coupled receptor activity G protein-coupled receptor binding integrin binding lipid binding sphingosine-1-phosphate receptor activity Homo sapiens 3D-structure Cell membrane Deafness Disease variant G-protein coupled receptor Glycoprotein Lipoprotein Membrane Non-syndromic deafness Palmitate Receptor Reference proteome Transducer Transmembrane Transmembrane helix MGSLYSEYLN MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV |
aerobic respiration apoptotic process blastocyst formation camera-type eye morphogenesis mitochondrial fusion mitochondrial membrane organization mitochondrion localization negative regulation of Ras protein signal transduction negative regulation of smooth muscle cell proliferation parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization positive regulation of cold-induced thermogenesis positive regulation of vascular associated smooth muscle cell apoptotic process positive regulation of vascular associated smooth muscle cell proliferation protein localization to phagophore assembly site protein targeting to mitochondrion response to unfolded protein | cytosol; microtubule cytoskeleton; mitochondrial outer membrane; mitochondrion | GTP binding GTPase activity ubiquitin protein ligase binding | Homo sapiens | 3D-structure Alternative splicing Apoptosis Autophagy Charcot-Marie-Tooth disease Coiled coil Disease variant GTP-binding Hydrolase Membrane Mitochondrion Mitochondrion outer membrane Neurodegeneration Neuropathy Nucleotide-binding Phosphoprotein Reference proteome Transmembrane Transmembrane helix Ubl conjugation Unfolded protein response | MSLLFSRCNS | MSLLFSRCNSIVTVKKNKRHMAEVNASPLKHFVTAKKKINGIFEQLGAYIQESATFLEDTYRNAELDPVTTEEQVLDVKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVEGTDGHEAFLLTEGSEEKRSAKTVNQLAHALHQDKQLHAGSLVSVMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKHFFHKVSERLSRPNIFILNNRWDASASEPEYMEEVRRQHMERCTSFLVDELGVVDRSQAGDRIFFVSAKEVLNARIQKAQGMPEGGGALAEGFQVRMFEFQNFERRFEECISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHMAAREQQVYCEEMREERQDRLKFIDKQLELLAQDYKLRIKQITEEVERQVSTAMAEEIRRLSVLVDDYQMDFHPSPVVLKVYKNELHRHIEEGLGRNMSDRCSTAITNSLQTMQQDMIDGLKPLLPVSVRSQIDMLVPRQCFSLNYDLNCDKLCADFQEDIEFHFSLGWTMLVNRFLGPKNSRRALMGYNDQVQRPIPLTPANPSMPPLPQGSLTQEEFMVSMVTGLASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYERLTWTTKAKERAFKRQFVEHASEKLQLVISYTGSNCSHQVQQELSGTFAHLCQQVDVTRENLEQEIAAMNKKIEVLDSLQSKAKLLRNKAGWLDSELNMFTHQYLQPSR | aerobic respiration apoptotic process blastocyst formation camera-type eye morphogenesis mitochondrial fusion mitochondrial membrane organization mitochondrion localization negative regulation of Ras protein signal transduction negative regulation of smooth muscle cell proliferation parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization positive regulation of cold-induced thermogenesis positive regulation of vascular associated smooth muscle cell apoptotic process positive regulation of vascular associated smooth muscle cell proliferation protein localization to phagophore assembly site protein targeting to mitochondrion response to unfolded protein cytosol; microtubule cytoskeleton; mitochondrial outer membrane; mitochondrion GTP binding GTPase activity ubiquitin protein ligase binding Homo sapiens 3D-structure Alternative splicing Apoptosis Autophagy Charcot-Marie-Tooth disease Coiled coil Disease variant GTP-binding Hydrolase Membrane Mitochondrion Mitochondrion outer membrane Neurodegeneration Neuropathy Nucleotide-binding Phosphoprotein Reference proteome Transmembrane Transmembrane helix Ubl conjugation Unfolded protein response MSLLFSRCNS MSLLFSRCNSIVTVKKNKRHMAEVNASPLKHFVTAKKKINGIFEQLGAYIQESATFLEDTYRNAELDPVTTEEQVLDVKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVEGTDGHEAFLLTEGSEEKRSAKTVNQLAHALHQDKQLHAGSLVSVMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKHFFHKVSERLSRPNIFILNNRWDASASEPEYMEEVRRQHMERCTSFLVDELGVVDRSQAGDRIFFVSAKEVLNARIQKAQGMPEGGGALAEGFQVRMFEFQNFERRFEECISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHMAAREQQVYCEEMREERQDRLKFIDKQLELLAQDYKLRIKQITEEVERQVSTAMAEEIRRLSVLVDDYQMDFHPSPVVLKVYKNELHRHIEEGLGRNMSDRCSTAITNSLQTMQQDMIDGLKPLLPVSVRSQIDMLVPRQCFSLNYDLNCDKLCADFQEDIEFHFSLGWTMLVNRFLGPKNSRRALMGYNDQVQRPIPLTPANPSMPPLPQGSLTQEEFMVSMVTGLASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYERLTWTTKAKERAFKRQFVEHASEKLQLVISYTGSNCSHQVQQELSGTFAHLCQQVDVTRENLEQEIAAMNKKIEVLDSLQSKAKLLRNKAGWLDSELNMFTHQYLQPSR |
protein import into nucleus RNA import into nucleus snRNA import into nucleus | cytosol; NLS-dependent protein nuclear import complex; nuclear pore; nucleoplasm; plasma membrane | nuclear import signal receptor activity RNA cap binding | Homo sapiens | 3D-structure Acetylation Cytoplasm Direct protein sequencing Nucleus Phosphoprotein Reference proteome RNA-binding Transport | MEELSQALAS | MEELSQALASSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVNHARRLAEDDWTGMESEEENKKDDEEMDIDTVKKLPKHYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTAKDYTILDCIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPDYAGHQLQQIMEHKKSQKEGMKEKLTHKASENGHYELEHLSTPKLKGSSHSPDHPGCLMEN | protein import into nucleus RNA import into nucleus snRNA import into nucleus cytosol; NLS-dependent protein nuclear import complex; nuclear pore; nucleoplasm; plasma membrane nuclear import signal receptor activity RNA cap binding Homo sapiens 3D-structure Acetylation Cytoplasm Direct protein sequencing Nucleus Phosphoprotein Reference proteome RNA-binding Transport MEELSQALAS MEELSQALASSFSVSQDLNSTAAPHPRLSQYKSKYSSLEQSERRRRLLELQKSKRLDYVNHARRLAEDDWTGMESEEENKKDDEEMDIDTVKKLPKHYANQLMLSEWLIDVPSDLGQEWIVVVCPVGKRALIVASRGSTSAYTKSGYCVNRFSSLLPGGNRRNSTAKDYTILDCIYNEVNQTYYVLDVMCWRGHPFYDCQTDFRFYWMHSKLPEEEGLGEKTKLNPFKFVGLKNFPCTPESLCDVLSMDFPFEVDGLLFYHKQTHYSPGSTPLVGWLRPYMVSDVLGVAVPAGPLTTKPDYAGHQLQQIMEHKKSQKEGMKEKLTHKASENGHYELEHLSTPKLKGSSHSPDHPGCLMEN |
activation of cysteine-type endopeptidase activity involved in apoptotic process activation of NF-kappaB-inducing kinase activity immune response signal transduction | extracellular space; membrane; plasma membrane | cytokine activity signaling receptor binding tumor necrosis factor receptor binding | Homo sapiens | 3D-structure Alternative splicing Cytokine Direct protein sequencing Disulfide bond Glycoprotein Membrane Reference proteome Secreted Signal-anchor Transmembrane Transmembrane helix | MAEDLGLSFG | MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL | activation of cysteine-type endopeptidase activity involved in apoptotic process activation of NF-kappaB-inducing kinase activity immune response signal transduction extracellular space; membrane; plasma membrane cytokine activity signaling receptor binding tumor necrosis factor receptor binding Homo sapiens 3D-structure Alternative splicing Cytokine Direct protein sequencing Disulfide bond Glycoprotein Membrane Reference proteome Secreted Signal-anchor Transmembrane Transmembrane helix MAEDLGLSFG MAEDLGLSFGETASVEMLPEHGSCRPKARSSSARWALTCCLVLLPFLAGLTTYLLVSQLRAQGEACVQFQALKGQEFAPSHQQVYAPLRADGDKPRAHLTVVRQTPTQHFKNQFPALHWEHELGLAFTKNRMNYTNKFLLIPESGDYFIYSQVTFRGMTSECSEIRQAGRPNKPDSITVVITKVTDSYPEPTQLLMGTKSVCEVGSNWFQPIYLGAMFSLQEGDKLMVNVSDISLVDYTKEDKTFFGAFLL |
cellular aldehyde metabolic process | cytoplasm; cytosol; extracellular exosome; Golgi apparatus | aldo-keto reductase (NADP) activity electron transfer activity identical protein binding | Homo sapiens | 3D-structure Cytoplasm NAD NADP Oxidoreductase Phosphoprotein Reference proteome | MSRQLSRARP | MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVTHECPNYFR | cellular aldehyde metabolic process cytoplasm; cytosol; extracellular exosome; Golgi apparatus aldo-keto reductase (NADP) activity electron transfer activity identical protein binding Homo sapiens 3D-structure Cytoplasm NAD NADP Oxidoreductase Phosphoprotein Reference proteome MSRQLSRARP MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGGLGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTPVEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVETELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEHHFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAAAEEGPLEPAVVDAFNQAWHLVTHECPNYFR |
regulation of DNA-templated transcription vesicle-mediated transport | Golgi apparatus; membrane; nucleus | DNA binding zinc ion binding | Homo sapiens | ER-Golgi transport Golgi apparatus Membrane Metal-binding Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport Zinc Zinc-finger | MGLCKCPKRK | MGLCKCPKRKVTNLFCFEHRVNVCEHCLVANHAKCIVQSYLQWLQDSDYNPNCRLCNIPLASRETTRLVCYDLFHWACLNERAAQLPRNTAPAGYQCPSCNGPIFPPTNLAGPVASALREKLATVNWARAGLGLPLIDEVVSPEPEPLNTSDFSDWSSFNASSTPGPEEVDSASAAPAFYSQAPRPPASPGRPEQHTVIHMGNPEPLTHAPRKVYDTRDDDRTPGLHGDCDDDKYRRRPALGWLARLLRSRAGSRKRPLTLLQRAGLLLLLGLLGFLALLALMSRLGRAAADSDPNLDPLMNPHIRVGPS | regulation of DNA-templated transcription vesicle-mediated transport Golgi apparatus; membrane; nucleus DNA binding zinc ion binding Homo sapiens ER-Golgi transport Golgi apparatus Membrane Metal-binding Phosphoprotein Reference proteome Transmembrane Transmembrane helix Transport Zinc Zinc-finger MGLCKCPKRK MGLCKCPKRKVTNLFCFEHRVNVCEHCLVANHAKCIVQSYLQWLQDSDYNPNCRLCNIPLASRETTRLVCYDLFHWACLNERAAQLPRNTAPAGYQCPSCNGPIFPPTNLAGPVASALREKLATVNWARAGLGLPLIDEVVSPEPEPLNTSDFSDWSSFNASSTPGPEEVDSASAAPAFYSQAPRPPASPGRPEQHTVIHMGNPEPLTHAPRKVYDTRDDDRTPGLHGDCDDDKYRRRPALGWLARLLRSRAGSRKRPLTLLQRAGLLLLLGLLGFLALLALMSRLGRAAADSDPNLDPLMNPHIRVGPS |
autophagosome assembly cellular response to nitrogen starvation chemical synaptic transmission extrinsic apoptotic signaling pathway via death domain receptors macroautophagy microtubule cytoskeleton organization positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein K48-linked ubiquitination protein targeting protein transport regulation of Rac protein signal transduction | actin cytoskeleton; autophagosome; autophagosome membrane; axoneme; cytoplasmic vesicle; cytosol; Golgi membrane; lysosome; microtubule; microtubule associated complex; plasma membrane; smooth endoplasmic reticulum; sperm midpiece; synapse | beta-tubulin binding GABA receptor binding microtubule binding phosphatidylethanolamine binding ubiquitin protein ligase binding | Homo sapiens | 3D-structure Apoptosis Autophagy Cytoplasm Cytoplasmic vesicle Cytoskeleton Golgi apparatus Lipoprotein Membrane Microtubule Protein transport Reference proteome Transport | MKFVYKEEHP | MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL | autophagosome assembly cellular response to nitrogen starvation chemical synaptic transmission extrinsic apoptotic signaling pathway via death domain receptors macroautophagy microtubule cytoskeleton organization positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein K48-linked ubiquitination protein targeting protein transport regulation of Rac protein signal transduction actin cytoskeleton; autophagosome; autophagosome membrane; axoneme; cytoplasmic vesicle; cytosol; Golgi membrane; lysosome; microtubule; microtubule associated complex; plasma membrane; smooth endoplasmic reticulum; sperm midpiece; synapse beta-tubulin binding GABA receptor binding microtubule binding phosphatidylethanolamine binding ubiquitin protein ligase binding Homo sapiens 3D-structure Apoptosis Autophagy Cytoplasm Cytoplasmic vesicle Cytoskeleton Golgi apparatus Lipoprotein Membrane Microtubule Protein transport Reference proteome Transport MKFVYKEEHP MKFVYKEEHPFEKRRSEGEKIRKKYPDRVPVIVEKAPKARIGDLDKKKYLVPSDLTVGQFYFLIRKRIHLRAEDALFFFVNNVIPPTSATMGQLYQEHHEEDFFLYIAYSDESVYGL |
embryo development ending in birth or egg hatching epidermis development keratinocyte differentiation positive regulation of canonical Wnt signaling pathway response to mechanical stimulus | cornified envelope; cytoplasm; extracellular exosome; perinuclear region of cytoplasm | metal ion binding | Homo sapiens | Acetylation Alternative splicing Cytoplasm Direct protein sequencing LIM domain Membrane Metal-binding Phosphoprotein Reference proteome Repeat Zinc | MSNVTLRKMS | MSNVTLRKMSPTGNEMKSTTQGTTRKQQDFHEVNKRRTFLQDNSWIKKRPEEEKDENYGRVVLNRHNSHDALDRKVNERDVPKATISRYSSDDTLDRISDRNDAAKTYKANTLDNQLTNRSMSMFRSLEVTKLQPGGSLNANTSNTIASTSATTPVKKKRQSWFPPPPPGYNASSSTGTRRREPGVHPPIPPKPSSPVSSPNQLRQDNRQIHPPKPGVYTETNRSAERNIRSQDLDNIVKVATSLQRSDKGEELDNLIKMNKSLNRNQGLDSLFRANPKVEEREKRAKSLESLIYMSTRTDKDGKGIQSLGSPIKVNQRTDKNEKGRQNLESVAKVNARMNKTSRRSEDLDNATEVNPKGHENTTGKKDLDGLIKVDPETNKNITRGQSLDNLIKVTPEVKRSNQGSKDLNNFIKVYPGTEKSTEGGQSLDSLIKVTPERNRTNQGNQDLENLIKVIPSANKSSEQGLDEHINVSPKAVKNTDGKQDLDKLIKVNPEIFTNNQRNQDLANLIKVNPAVIRNNQSQDLDNLIKVKPSALRNTNRDQNLENLIEVNSHVSENKNGSSNTGAKQAGPQDTVVYTRTYVENSKSPKDGYQENISGKYIQTVYSTSDRSVIERDMCTYCRKPLGVETKMILDELQICCHSTCFKCEICKQPLENLQAGDSIWIYRQTIHCEPCYSKIMAKWIP | embryo development ending in birth or egg hatching epidermis development keratinocyte differentiation positive regulation of canonical Wnt signaling pathway response to mechanical stimulus cornified envelope; cytoplasm; extracellular exosome; perinuclear region of cytoplasm metal ion binding Homo sapiens Acetylation Alternative splicing Cytoplasm Direct protein sequencing LIM domain Membrane Metal-binding Phosphoprotein Reference proteome Repeat Zinc MSNVTLRKMS MSNVTLRKMSPTGNEMKSTTQGTTRKQQDFHEVNKRRTFLQDNSWIKKRPEEEKDENYGRVVLNRHNSHDALDRKVNERDVPKATISRYSSDDTLDRISDRNDAAKTYKANTLDNQLTNRSMSMFRSLEVTKLQPGGSLNANTSNTIASTSATTPVKKKRQSWFPPPPPGYNASSSTGTRRREPGVHPPIPPKPSSPVSSPNQLRQDNRQIHPPKPGVYTETNRSAERNIRSQDLDNIVKVATSLQRSDKGEELDNLIKMNKSLNRNQGLDSLFRANPKVEEREKRAKSLESLIYMSTRTDKDGKGIQSLGSPIKVNQRTDKNEKGRQNLESVAKVNARMNKTSRRSEDLDNATEVNPKGHENTTGKKDLDGLIKVDPETNKNITRGQSLDNLIKVTPEVKRSNQGSKDLNNFIKVYPGTEKSTEGGQSLDSLIKVTPERNRTNQGNQDLENLIKVIPSANKSSEQGLDEHINVSPKAVKNTDGKQDLDKLIKVNPEIFTNNQRNQDLANLIKVNPAVIRNNQSQDLDNLIKVKPSALRNTNRDQNLENLIEVNSHVSENKNGSSNTGAKQAGPQDTVVYTRTYVENSKSPKDGYQENISGKYIQTVYSTSDRSVIERDMCTYCRKPLGVETKMILDELQICCHSTCFKCEICKQPLENLQAGDSIWIYRQTIHCEPCYSKIMAKWIP |
anterior/posterior axon guidance apoptotic process axon guidance brain development chemorepulsion of axon dorsal root ganglion development ectopic germ cell programmed cell death positive regulation of apoptotic process positive regulation of developmental process positive regulation of reproductive process regulation of neuron migration | cell surface; dendrite; filopodium; growth cone; lamellipodium; neuronal cell body; plasma membrane; synapse | netrin receptor activity netrin receptor activity involved in chemorepulsion protein kinase binding tubulin binding | Homo sapiens | Alternative splicing Alzheimer disease Amyloidosis Apoptosis Cell membrane Cell projection Developmental protein Disulfide bond Glycoprotein Immunoglobulin domain Membrane Neurodegeneration Phosphoprotein Receptor Reference proteome Repeat Signal Synapse Synaptosome Transmembrane Transmembrane helix | MRKGLRATAA | MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY | anterior/posterior axon guidance apoptotic process axon guidance brain development chemorepulsion of axon dorsal root ganglion development ectopic germ cell programmed cell death positive regulation of apoptotic process positive regulation of developmental process positive regulation of reproductive process regulation of neuron migration cell surface; dendrite; filopodium; growth cone; lamellipodium; neuronal cell body; plasma membrane; synapse netrin receptor activity netrin receptor activity involved in chemorepulsion protein kinase binding tubulin binding Homo sapiens Alternative splicing Alzheimer disease Amyloidosis Apoptosis Cell membrane Cell projection Developmental protein Disulfide bond Glycoprotein Immunoglobulin domain Membrane Neurodegeneration Phosphoprotein Receptor Reference proteome Repeat Signal Synapse Synaptosome Transmembrane Transmembrane helix MRKGLRATAA MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIQLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQMGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQY |
axon regeneration cell projection morphogenesis cytoskeleton organization glial cell projection elongation intracellular transport nervous system development positive regulation of substrate adhesion-dependent cell spreading regulation of synaptic vesicle exocytosis | cell surface; endoplasmic reticulum membrane; extracellular region; GABA-ergic synapse; glutamatergic synapse; Golgi apparatus; Golgi lumen; Golgi membrane; Golgi-associated vesicle membrane; lysosomal lumen; membrane; plasma membrane; postsynaptic membrane; synapse | growth factor activity | Homo sapiens | Alternative splicing Cell membrane Developmental protein Differentiation Disulfide bond EGF-like domain Endoplasmic reticulum Glycoprotein Golgi apparatus Growth regulation Membrane Neurogenesis Phosphoprotein Proteoglycan Reference proteome Secreted Signal Synapse Transmembrane Transmembrane helix | MGRAGGGGPG | MGRAGGGGPGRGPPPLLLFLGAALVLASGAVPAREAGSAVEAEELVKGSPAWEPPANDTREEAGPPAAGEDEASWTAPGGELAGPEEVLQESAAVTGTAWLEADSPGLGGVTAEAGSGDAQALPATLQAPHEVLGQSIMPPAIPEATEASGPPSPTPGDKLSPASELPKESPLEVWLNLGGSTPDPQGPELTYPFQGTLEPQPASDIIDIDYFEGLDGEGRGADLGSFPGSPGTSENHPDTEGETPSWSLLDLYDDFTPFDESDFYPTTSFYDDLDEEEEEEEDDKDAVGGGDLEDENELLVPTGKPGLGPGTGQPTSRWHAVPPQHTLGSVPGSSIALRPRPGEPGRDLASSENGTECRSGFVRHNGSCRSVCDLFPSYCHNGGQCYLVENIGAFCRCNTQDYIWHKGMRCESIITDFQVMCVAVGSAALVLLLLFMMTVFFAKKLYLLKTENTKLRRTNKFRTPSELHNDNFSLSTIAEGSHPNVRKLCNTPRTSSPHARALAHYDNVICQDDPSAPHKIQEVLKSCLKEEESFNIQNSMSPKLEGGKGDQADLDVNCLQNNLT | axon regeneration cell projection morphogenesis cytoskeleton organization glial cell projection elongation intracellular transport nervous system development positive regulation of substrate adhesion-dependent cell spreading regulation of synaptic vesicle exocytosis cell surface; endoplasmic reticulum membrane; extracellular region; GABA-ergic synapse; glutamatergic synapse; Golgi apparatus; Golgi lumen; Golgi membrane; Golgi-associated vesicle membrane; lysosomal lumen; membrane; plasma membrane; postsynaptic membrane; synapse growth factor activity Homo sapiens Alternative splicing Cell membrane Developmental protein Differentiation Disulfide bond EGF-like domain Endoplasmic reticulum Glycoprotein Golgi apparatus Growth regulation Membrane Neurogenesis Phosphoprotein Proteoglycan Reference proteome Secreted Signal Synapse Transmembrane Transmembrane helix MGRAGGGGPG MGRAGGGGPGRGPPPLLLFLGAALVLASGAVPAREAGSAVEAEELVKGSPAWEPPANDTREEAGPPAAGEDEASWTAPGGELAGPEEVLQESAAVTGTAWLEADSPGLGGVTAEAGSGDAQALPATLQAPHEVLGQSIMPPAIPEATEASGPPSPTPGDKLSPASELPKESPLEVWLNLGGSTPDPQGPELTYPFQGTLEPQPASDIIDIDYFEGLDGEGRGADLGSFPGSPGTSENHPDTEGETPSWSLLDLYDDFTPFDESDFYPTTSFYDDLDEEEEEEEDDKDAVGGGDLEDENELLVPTGKPGLGPGTGQPTSRWHAVPPQHTLGSVPGSSIALRPRPGEPGRDLASSENGTECRSGFVRHNGSCRSVCDLFPSYCHNGGQCYLVENIGAFCRCNTQDYIWHKGMRCESIITDFQVMCVAVGSAALVLLLLFMMTVFFAKKLYLLKTENTKLRRTNKFRTPSELHNDNFSLSTIAEGSHPNVRKLCNTPRTSSPHARALAHYDNVICQDDPSAPHKIQEVLKSCLKEEESFNIQNSMSPKLEGGKGDQADLDVNCLQNNLT |
protein ubiquitination | actin cytoskeleton; Cul3-RING ubiquitin ligase complex; cytoplasm; cytosol; lamellipodium; ruffle | actin binding identical protein binding ubiquitin ligase-substrate adaptor activity | Homo sapiens | 3D-structure Actin-binding Alternative splicing Cell projection Cytoplasm Cytoskeleton Kelch repeat Reference proteome Repeat Ubl conjugation pathway | METPPLPPAC | METPPLPPACTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL | protein ubiquitination actin cytoskeleton; Cul3-RING ubiquitin ligase complex; cytoplasm; cytosol; lamellipodium; ruffle actin binding identical protein binding ubiquitin ligase-substrate adaptor activity Homo sapiens 3D-structure Actin-binding Alternative splicing Cell projection Cytoplasm Cytoskeleton Kelch repeat Reference proteome Repeat Ubl conjugation pathway METPPLPPAC METPPLPPACTKQGHQKPLDSKDDNTEKHCPVTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL |
negative regulation of transcription by RNA polymerase II positive regulation of hydrogen peroxide biosynthetic process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of DNA-templated transcription regulation of transcription by RNA polymerase II | mitochondrion; nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding zinc ion binding | Homo sapiens | DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MSADGGGIQD | MSADGGGIQDTQDKETPPEVPDRGHPHQEMPSKLGEAVPSGDTQESLHIKMEPEEPHSEGASQEDGAQGAWGWAPLSHGSKEKALFLPGGALPSPRIPVLSREGRTRDRQMAAALLTAWSQMPVTFEDVALYLSREEWGRLDHTQQNFYRDVLQKKNGLSLGFPFSRPFWAPQAHGKGEASGSSRQAGDEKEWRGACTGAVEVGQRVQTSSVAALGNVKPFRTRAGRVQWGVPQCAQEAACGRSSGPAKDSGQPAEPDRTPDAAPPDPSPTEPQEYRVPEKPNEEEKGAPESGEEGLAPDSEVGRKSYRCEQCGKGFSWHSHLVTHRRTHTGEKPYACTDCGKRFGRSSHLIQHQIIHTGEKPYTCPACRKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICAKCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYACPLCGKSFSRRSNLHRHEKIHTTGPKALAMLMLGAAAAGALATPPPAPT | negative regulation of transcription by RNA polymerase II positive regulation of hydrogen peroxide biosynthetic process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway regulation of DNA-templated transcription regulation of transcription by RNA polymerase II mitochondrion; nucleus DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding zinc ion binding Homo sapiens DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger MSADGGGIQD MSADGGGIQDTQDKETPPEVPDRGHPHQEMPSKLGEAVPSGDTQESLHIKMEPEEPHSEGASQEDGAQGAWGWAPLSHGSKEKALFLPGGALPSPRIPVLSREGRTRDRQMAAALLTAWSQMPVTFEDVALYLSREEWGRLDHTQQNFYRDVLQKKNGLSLGFPFSRPFWAPQAHGKGEASGSSRQAGDEKEWRGACTGAVEVGQRVQTSSVAALGNVKPFRTRAGRVQWGVPQCAQEAACGRSSGPAKDSGQPAEPDRTPDAAPPDPSPTEPQEYRVPEKPNEEEKGAPESGEEGLAPDSEVGRKSYRCEQCGKGFSWHSHLVTHRRTHTGEKPYACTDCGKRFGRSSHLIQHQIIHTGEKPYTCPACRKSFSHHSTLIQHQRIHTGEKPYVCDRCAKRFTRRSDLVTHQGTHTGAKPHKCPICAKCFTQSSALVTHQRTHTGVKPYPCPECGKCFSQRSNLIAHNRTHTGEKPYHCLDCGKSFSHSSHLTAHQRTHRGVRPYACPLCGKSFSRRSNLHRHEKIHTTGPKALAMLMLGAAAAGALATPPPAPT |
calcium export from the mitochondrion calcium ion transport cristae formation inner mitochondrial membrane organization mitochondrial calcium ion homeostasis mitochondrial calcium ion transmembrane transport mitochondrial potassium ion transmembrane transport negative regulation of mitochondrial calcium ion concentration protein hexamerization protein homooligomerization regulation of cellular hyperosmotic salinity response | mitochondrial inner membrane; mitochondrion | calcium ion binding calcium:proton antiporter activity ribosome binding | Homo sapiens | Acetylation Alternative splicing Antiport Calcium Calcium transport Coiled coil Disease variant Ion transport Membrane Metal-binding Mitochondrion Mitochondrion inner membrane Neurodegeneration Phosphoprotein Potassium Potassium transport Reference proteome Transit peptide Transmembrane Transmembrane helix Transport | MASILLRSCR | MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS | calcium export from the mitochondrion calcium ion transport cristae formation inner mitochondrial membrane organization mitochondrial calcium ion homeostasis mitochondrial calcium ion transmembrane transport mitochondrial potassium ion transmembrane transport negative regulation of mitochondrial calcium ion concentration protein hexamerization protein homooligomerization regulation of cellular hyperosmotic salinity response mitochondrial inner membrane; mitochondrion calcium ion binding calcium:proton antiporter activity ribosome binding Homo sapiens Acetylation Alternative splicing Antiport Calcium Calcium transport Coiled coil Disease variant Ion transport Membrane Metal-binding Mitochondrion Mitochondrion inner membrane Neurodegeneration Phosphoprotein Potassium Potassium transport Reference proteome Transit peptide Transmembrane Transmembrane helix Transport MASILLRSCR MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHPVYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVVEKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAARMLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS |
endocytosis negative regulation of sprouting angiogenesis negative regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of Notch signaling pathway | clathrin vesicle coat; cytosol; endosome; intracellular membrane-bounded organelle; plasma membrane | cadherin binding clathrin binding phospholipid binding | Homo sapiens | Alternative splicing Cytoplasm Cytoplasmic vesicle Endocytosis Lipid-binding Methylation Phosphoprotein Reference proteome Repeat Ubl conjugation | MTTSSIRRQM | MTTSSIRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTSHSEQEYGKAGGSPASYHGSPEASLCPQHRTGAPLGQSEELQPLSQRHPFLPHLGLASRPNGDWSQPCLTCDRAARATSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLRRGDDLRLQMALEESRRDTVKIPKKKEHGSLPQQTTLLDLMDALPSSGPAAQKAEPWGPSASTNQTNPWGGPAAPASTSDPWPSFGTKPAASIDPWGVPTGATVQSVPKNSDPWAASQQPASSAGKRASDAWGAVSTTKPVSVSGSFELFSNLNGTIKDDFSEFDNLRTSKKTAESVTSLPSQNNGTTSPDPFESQPLTVASSKPSSARKTPESFLGPNAALVNLDSLVTRPAPPAQSLNPFLAPGAPATSAPVNPFQVNQPQPLTLNQLRGSPVLGTSTSFGPGPGVESMAVASMTSAAPQPALGATGSSLTPLGPAMMNMVGSVGIPPSAAQATGTTNPFLL | endocytosis negative regulation of sprouting angiogenesis negative regulation of vascular endothelial growth factor receptor signaling pathway positive regulation of Notch signaling pathway clathrin vesicle coat; cytosol; endosome; intracellular membrane-bounded organelle; plasma membrane cadherin binding clathrin binding phospholipid binding Homo sapiens Alternative splicing Cytoplasm Cytoplasmic vesicle Endocytosis Lipid-binding Methylation Phosphoprotein Reference proteome Repeat Ubl conjugation MTTSSIRRQM MTTSSIRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMVWKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQGINVREKSKQLVALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTSHSEQEYGKAGGSPASYHGSPEASLCPQHRTGAPLGQSEELQPLSQRHPFLPHLGLASRPNGDWSQPCLTCDRAARATSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLRRGDDLRLQMALEESRRDTVKIPKKKEHGSLPQQTTLLDLMDALPSSGPAAQKAEPWGPSASTNQTNPWGGPAAPASTSDPWPSFGTKPAASIDPWGVPTGATVQSVPKNSDPWAASQQPASSAGKRASDAWGAVSTTKPVSVSGSFELFSNLNGTIKDDFSEFDNLRTSKKTAESVTSLPSQNNGTTSPDPFESQPLTVASSKPSSARKTPESFLGPNAALVNLDSLVTRPAPPAQSLNPFLAPGAPATSAPVNPFQVNQPQPLTLNQLRGSPVLGTSTSFGPGPGVESMAVASMTSAAPQPALGATGSSLTPLGPAMMNMVGSVGIPPSAAQATGTTNPFLL |
glycogen catabolic process glycophagy intracellular transport substrate localization to autophagosome | endoplasmic reticulum; endoplasmic reticulum membrane; ficolin-1-rich granule membrane; membrane; perinuclear region of cytoplasm; phagophore assembly site membrane; plasma membrane; T-tubule; tertiary granule membrane | cargo receptor activity enzyme binding glycogen binding polysaccharide binding starch binding | Homo sapiens | Autophagy Carbohydrate metabolism Cell membrane Endoplasmic reticulum Glycogen metabolism Membrane Phosphoprotein Reference proteome Signal-anchor Transmembrane Transmembrane helix Ubl conjugation | MGAVWSALLV | MGAVWSALLVGGGLAGALFVWLLRGGPGDTGKDGDAEQEKDAPLGGAAIPGGHQSGSSGLSPGPSGQELVTKPEHLQESNGHLISKTKDLGKLQAASWRLQNPSREVCDNSREHVPSGQFPDTEAPATSETSNSRSYSEVSRNESLESPMGEWGFQKGQEISAKAATCFAEKLPSSNLLKNRAKEEMSLSDLNSQDRVDHEEWEMVPRHSSWGDVGVGGSLKAPVLNLNQGMDNGRSTLVEARGQQVHGKMERVAVMPAGSQQVSVRFQVHYVTSTDVQFIAVTGDHECLGRWNTYIPLHYNKDGFWSHSIFLPADTVVEWKFVLVENGGVTRWEECSNRFLETGHEDKVVHAWWGIH | glycogen catabolic process glycophagy intracellular transport substrate localization to autophagosome endoplasmic reticulum; endoplasmic reticulum membrane; ficolin-1-rich granule membrane; membrane; perinuclear region of cytoplasm; phagophore assembly site membrane; plasma membrane; T-tubule; tertiary granule membrane cargo receptor activity enzyme binding glycogen binding polysaccharide binding starch binding Homo sapiens Autophagy Carbohydrate metabolism Cell membrane Endoplasmic reticulum Glycogen metabolism Membrane Phosphoprotein Reference proteome Signal-anchor Transmembrane Transmembrane helix Ubl conjugation MGAVWSALLV MGAVWSALLVGGGLAGALFVWLLRGGPGDTGKDGDAEQEKDAPLGGAAIPGGHQSGSSGLSPGPSGQELVTKPEHLQESNGHLISKTKDLGKLQAASWRLQNPSREVCDNSREHVPSGQFPDTEAPATSETSNSRSYSEVSRNESLESPMGEWGFQKGQEISAKAATCFAEKLPSSNLLKNRAKEEMSLSDLNSQDRVDHEEWEMVPRHSSWGDVGVGGSLKAPVLNLNQGMDNGRSTLVEARGQQVHGKMERVAVMPAGSQQVSVRFQVHYVTSTDVQFIAVTGDHECLGRWNTYIPLHYNKDGFWSHSIFLPADTVVEWKFVLVENGGVTRWEECSNRFLETGHEDKVVHAWWGIH |
late endosome to vacuole transport via multivesicular body sorting pathway negative regulation of growth hormone receptor signaling pathway | endosome; membrane | identical protein binding | Homo sapiens | Alternative splicing Membrane Reference proteome Transmembrane Transmembrane helix | MAGIKALISL | MAGIKALISLSFGGAIGLMFLMLGCALPIYNKYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELAIFLTTGIVVSAFGLPIVFARAHLIEWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW | late endosome to vacuole transport via multivesicular body sorting pathway negative regulation of growth hormone receptor signaling pathway endosome; membrane identical protein binding Homo sapiens Alternative splicing Membrane Reference proteome Transmembrane Transmembrane helix MAGIKALISL MAGIKALISLSFGGAIGLMFLMLGCALPIYNKYWPLFVLFFYILSPIPYCIARRLVDDTDAMSNACKELAIFLTTGIVVSAFGLPIVFARAHLIEWGACALVLTGNTVIFATILGFFLVFGSNDDFSWQQW |
mRNA processing RNA splicing | nucleoplasm | lipopolysaccharide binding metal ion binding RNA binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Metal-binding mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Repeat RNA-binding Zinc Zinc-finger | MSTKNFRVSD | MSTKNFRVSDGDWICPDKKCGNVNFARRTSCNRCGREKTTEAKMMKAGGTEIGKTLAEKSRGLFSANDWQCKTCSNVNWARRSECNMCNTPKYAKLEERTGYGGGFNERENVEYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSPERRHRSSSGSSHSGSRSSSKKK | mRNA processing RNA splicing nucleoplasm lipopolysaccharide binding metal ion binding RNA binding Homo sapiens 3D-structure Acetylation Alternative splicing Metal-binding mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Repeat RNA-binding Zinc Zinc-finger MSTKNFRVSD MSTKNFRVSDGDWICPDKKCGNVNFARRTSCNRCGREKTTEAKMMKAGGTEIGKTLAEKSRGLFSANDWQCKTCSNVNWARRSECNMCNTPKYAKLEERTGYGGGFNERENVEYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDEDEDEDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRKRSYSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSPERRHRSSSGSSHSGSRSSSKKK |
endocytic recycling positive regulation of autophagosome assembly positive regulation of histamine secretion by mast cell protein transport | cytoplasm; cytoplasmic dynein complex; early endosome; early endosome membrane; membrane; plasma membrane; presynaptic endosome; protein-containing complex; SNARE complex | epidermal growth factor receptor binding insulin receptor binding leptin receptor binding phosphatidylinositol binding phosphatidylinositol-3-phosphate binding transferrin receptor binding | Homo sapiens | Acetylation Alternative splicing Endosome Lipid-binding Membrane Phosphoprotein Protein transport Reference proteome Transport | MEQAPPDPER | MEQAPPDPERQLQPAPLEPLGSPDAGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILEDEEHYADQLKEYLFYAEALRAVCRKHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLEEQINEGEQQLKSKNLEGREFVKNAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQVWTNAKECFSKM | endocytic recycling positive regulation of autophagosome assembly positive regulation of histamine secretion by mast cell protein transport cytoplasm; cytoplasmic dynein complex; early endosome; early endosome membrane; membrane; plasma membrane; presynaptic endosome; protein-containing complex; SNARE complex epidermal growth factor receptor binding insulin receptor binding leptin receptor binding phosphatidylinositol binding phosphatidylinositol-3-phosphate binding transferrin receptor binding Homo sapiens Acetylation Alternative splicing Endosome Lipid-binding Membrane Phosphoprotein Protein transport Reference proteome Transport MEQAPPDPER MEQAPPDPERQLQPAPLEPLGSPDAGLGAAVGKEAEGAGEESSGVDTMTHNNFWLKKIEISVSEAEKRTGRNAMNMQETYTAYLIETRSVEHTDGQSVLTDSLWRRYSEFELLRSYLLVYYPHIVVPPLPEKRAEFVWHKLSADNMDPDFVERRRIGLENFLLRIASHPILCRDKIFYLFLTQEGNWKETVNETGFQLKADSRLKALNATFRVKNPDKRFTDLKHYSDELQSVISHLLRVRARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYASSIDDILEDEEHYADQLKEYLFYAEALRAVCRKHELMQYDLEMAAQDLASKKQQCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLEEQINEGEQQLKSKNLEGREFVKNAWADIERFKEQKNRDLKEALISYAVMQISMCKKGIQVWTNAKECFSKM |
positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II | chromatin; nucleoplasm | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Developmental protein DNA-binding Homeobox Nucleus Reference proteome | MRLSSSPPRG | MRLSSSPPRGPQQLSSFGSVDWLSQSSCSGPTHTPRPADFSLGSLPGPGQTSGAREPPQAVSIKEAAGSSNLPAPERTMAGLSKEPNTLRAPRVRTAFTMEQVRTLEGVFQHHQYLSPLERKRLAREMQLSEVQIKTWFQNRRMKHKRQMQDPQLHSPFSGSLHAPPAFYSTSSGLANGLQLLCPWAPLSGPQALMLPPGSFWGLCQVAQEALASAGASCCGQPLASHPPTPGRPSLGPALSTGPRGLCAMPQTGDAF | positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II chromatin; nucleoplasm DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens Developmental protein DNA-binding Homeobox Nucleus Reference proteome MRLSSSPPRG MRLSSSPPRGPQQLSSFGSVDWLSQSSCSGPTHTPRPADFSLGSLPGPGQTSGAREPPQAVSIKEAAGSSNLPAPERTMAGLSKEPNTLRAPRVRTAFTMEQVRTLEGVFQHHQYLSPLERKRLAREMQLSEVQIKTWFQNRRMKHKRQMQDPQLHSPFSGSLHAPPAFYSTSSGLANGLQLLCPWAPLSGPQALMLPPGSFWGLCQVAQEALASAGASCCGQPLASHPPTPGRPSLGPALSTGPRGLCAMPQTGDAF |
mRNA splice site recognition RNA splicing | nuclear speck; nucleoplasm; nucleus; U1 snRNP; U2-type prespliceosome | DNA binding mRNA binding RNA binding | Homo sapiens | Acetylation Alternative splicing Coiled coil DNA-binding Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Ubl conjugation | MISAAQLLDE | MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN | mRNA splice site recognition RNA splicing nuclear speck; nucleoplasm; nucleus; U1 snRNP; U2-type prespliceosome DNA binding mRNA binding RNA binding Homo sapiens Acetylation Alternative splicing Coiled coil DNA-binding Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Ubl conjugation MISAAQLLDE MISAAQLLDELMGRDRNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDENLRKQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEEKIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN |
microtubule bundle formation microtubule-based movement midbody abscission mitotic cytokinesis protein transport regulation of cytokinesis | Golgi apparatus; intercellular bridge; kinesin complex; microtubule; midbody; nucleoplasm; spindle | ATP binding ATP hydrolysis activity microtubule binding microtubule motor activity protein kinase binding | Homo sapiens | 3D-structure Acetylation Alternative splicing ATP-binding Cardiomyopathy Coiled coil Cytoplasm Cytoskeleton Disease variant Golgi apparatus Microtubule Motor protein Nucleotide-binding Phosphoprotein Protein transport Reference proteome Transport | MSQGILSPPA | MSQGILSPPAGLLSDDDVVVSPMFESTAADLGSVVRKNLLSDCSVVSTSLEDKQQVPSEDSMEKVKVYLRVRPLLPSELERQEDQGCVRIENVETLVLQAPKDSFALKSNERGIGQATHRFTFSQIFGPEVGQASFFNLTVKEMVKDVLKGQNWLIYTYGVTNSGKTHTIQGTIKDGGILPRSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEEMKKLSLLNGGLQEEELSTSLKRSVYIESRIGTSTSFDSGIAGLSSISQCTSSSQLDETSHRWAQPDTAPLPVPANIRFSIWISFFEIYNELLYDLLEPPSQQRKRQTLRLCEDQNGNPYVKDLNWIHVQDAEEAWKLLKVGRKNQSFASTHLNQNSSRSHSIFSIRILHLQGEGDIVPKISELSLCDLAGSERCKDQKSGERLKEAGNINTSLHTLGRCIAALRQNQQNRSKQNLVPFRDSKLTRVFQGFFTGRGRSCMIVNVNPCASTYDETLHVAKFSAIASQLVHAPPMQLGFPSLHSFIKEHSLQVSPSLEKGAKADTGLDDDIENEADISMYGKEELLQVVEAMKTLLLKERQEKLQLEMHLRDEICNEMVEQMQQREQWCSEHLDTQKELLEEMYEEKLNILKESLTSFYQEEIQERDEKIEELEALLQEARQQSVAHQQSGSELALRRSQRLAASASTQQLQEVKAKLQQCKAELNSTTEELHKYQKMLEPPPSAKPFTIDVDKKLEEGQKNIRLLRTELQKLGESLQSAERACCHSTGAGKLRQALTTCDDILIKQDQTLAELQNNMVLVKLDLRKKAACIAEQYHTVLKLQGQVSAKKRLGTNQENQQPNQQPPGKKPFLRNLLPRTPTCQSSTDCSPYARILRSRRSPLLKSGPFGKKY | microtubule bundle formation microtubule-based movement midbody abscission mitotic cytokinesis protein transport regulation of cytokinesis Golgi apparatus; intercellular bridge; kinesin complex; microtubule; midbody; nucleoplasm; spindle ATP binding ATP hydrolysis activity microtubule binding microtubule motor activity protein kinase binding Homo sapiens 3D-structure Acetylation Alternative splicing ATP-binding Cardiomyopathy Coiled coil Cytoplasm Cytoskeleton Disease variant Golgi apparatus Microtubule Motor protein Nucleotide-binding Phosphoprotein Protein transport Reference proteome Transport MSQGILSPPA MSQGILSPPAGLLSDDDVVVSPMFESTAADLGSVVRKNLLSDCSVVSTSLEDKQQVPSEDSMEKVKVYLRVRPLLPSELERQEDQGCVRIENVETLVLQAPKDSFALKSNERGIGQATHRFTFSQIFGPEVGQASFFNLTVKEMVKDVLKGQNWLIYTYGVTNSGKTHTIQGTIKDGGILPRSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEEMKKLSLLNGGLQEEELSTSLKRSVYIESRIGTSTSFDSGIAGLSSISQCTSSSQLDETSHRWAQPDTAPLPVPANIRFSIWISFFEIYNELLYDLLEPPSQQRKRQTLRLCEDQNGNPYVKDLNWIHVQDAEEAWKLLKVGRKNQSFASTHLNQNSSRSHSIFSIRILHLQGEGDIVPKISELSLCDLAGSERCKDQKSGERLKEAGNINTSLHTLGRCIAALRQNQQNRSKQNLVPFRDSKLTRVFQGFFTGRGRSCMIVNVNPCASTYDETLHVAKFSAIASQLVHAPPMQLGFPSLHSFIKEHSLQVSPSLEKGAKADTGLDDDIENEADISMYGKEELLQVVEAMKTLLLKERQEKLQLEMHLRDEICNEMVEQMQQREQWCSEHLDTQKELLEEMYEEKLNILKESLTSFYQEEIQERDEKIEELEALLQEARQQSVAHQQSGSELALRRSQRLAASASTQQLQEVKAKLQQCKAELNSTTEELHKYQKMLEPPPSAKPFTIDVDKKLEEGQKNIRLLRTELQKLGESLQSAERACCHSTGAGKLRQALTTCDDILIKQDQTLAELQNNMVLVKLDLRKKAACIAEQYHTVLKLQGQVSAKKRLGTNQENQQPNQQPPGKKPFLRNLLPRTPTCQSSTDCSPYARILRSRRSPLLKSGPFGKKY |
inflammatory response lipoprotein metabolic process positive regulation of canonical NF-kappaB signal transduction | cytoplasm; extracellular region; membrane | lipid binding lipid transporter activity | Homo sapiens | Alternative splicing Cytoplasm Lipid transport Reference proteome Transport | MGLGQGWGWE | MGLGQGWGWEASCFACLIRSCCQVVTFTFPFGFQGISQSLENVSGYYADARLEVGSTQLRTAGSCSHSFKRSFLEKKRFTEEATKYFRERVSPVHLQILLTNNEAWKRFVTAAELPRDEADALYEALKKLRTYAAIEDEYVQQKDEQFREWFLKEFPQVKRKIQESIEKLRALANGIEEVHRGCTISNVVSSSTGAASGIMSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSIVEHSYTSSAEAEASRLTATSIDRLKVFKEVMRDITPNLLSLLNNYYEATQTIGSEIRAIRQARARARLPVTTWRISAGSGGQAERTIAGTTRAVSRGARILSATTSGIFLALDVVNLVYESKHLHEGAKSASAEELRRQAQELEENLMELTQIYQRLNPCHTH | inflammatory response lipoprotein metabolic process positive regulation of canonical NF-kappaB signal transduction cytoplasm; extracellular region; membrane lipid binding lipid transporter activity Homo sapiens Alternative splicing Cytoplasm Lipid transport Reference proteome Transport MGLGQGWGWE MGLGQGWGWEASCFACLIRSCCQVVTFTFPFGFQGISQSLENVSGYYADARLEVGSTQLRTAGSCSHSFKRSFLEKKRFTEEATKYFRERVSPVHLQILLTNNEAWKRFVTAAELPRDEADALYEALKKLRTYAAIEDEYVQQKDEQFREWFLKEFPQVKRKIQESIEKLRALANGIEEVHRGCTISNVVSSSTGAASGIMSLAGLVLAPFTAGTSLALTAAGVGLGAASAVTGITTSIVEHSYTSSAEAEASRLTATSIDRLKVFKEVMRDITPNLLSLLNNYYEATQTIGSEIRAIRQARARARLPVTTWRISAGSGGQAERTIAGTTRAVSRGARILSATTSGIFLALDVVNLVYESKHLHEGAKSASAEELRRQAQELEENLMELTQIYQRLNPCHTH |
cellular response to leukemia inhibitory factor positive regulation of lipid transport response to bacterium response to retinoic acid response to vitamin A retinoid metabolic process retinol metabolic process visual perception vitamin A metabolic process | endoplasmic reticulum; endoplasmic reticulum membrane; multivesicular body; perinuclear region of cytoplasm; rough endoplasmic reticulum | acyltransferase activity lecithin:11-cis retinol acyltransferase activity O-palmitoyltransferase activity phosphatidylcholine-retinol O-acyltransferase activity retinoic acid binding retinol binding | Homo sapiens | Acyltransferase Cytoplasm Disease variant Endoplasmic reticulum Endosome Leber congenital amaurosis Lipid metabolism Membrane Reference proteome Sensory transduction Transferase Transmembrane Transmembrane helix Vision | MKNPMLEVVS | MKNPMLEVVSLLLEKLLLISNFTLFSSGAAGEDKGRNSFYETSSFHRGDVLEVPRTHLTHYGIYLGDNRVAHMMPDILLALTDDMGRTQKVVSNKRLILGVIVKVASIRVDTVEDFAYGANILVNHLDESLQKKALLNEEVARRAEKLLGFTPYSLLWNNCEHFVTYCRYGTPISPQSDKFCETVKIIIRDQRSVLASAVLGLASIVCTGLVSYTTLPAIFIPFFLWMAG | cellular response to leukemia inhibitory factor positive regulation of lipid transport response to bacterium response to retinoic acid response to vitamin A retinoid metabolic process retinol metabolic process visual perception vitamin A metabolic process endoplasmic reticulum; endoplasmic reticulum membrane; multivesicular body; perinuclear region of cytoplasm; rough endoplasmic reticulum acyltransferase activity lecithin:11-cis retinol acyltransferase activity O-palmitoyltransferase activity phosphatidylcholine-retinol O-acyltransferase activity retinoic acid binding retinol binding Homo sapiens Acyltransferase Cytoplasm Disease variant Endoplasmic reticulum Endosome Leber congenital amaurosis Lipid metabolism Membrane Reference proteome Sensory transduction Transferase Transmembrane Transmembrane helix Vision MKNPMLEVVS MKNPMLEVVSLLLEKLLLISNFTLFSSGAAGEDKGRNSFYETSSFHRGDVLEVPRTHLTHYGIYLGDNRVAHMMPDILLALTDDMGRTQKVVSNKRLILGVIVKVASIRVDTVEDFAYGANILVNHLDESLQKKALLNEEVARRAEKLLGFTPYSLLWNNCEHFVTYCRYGTPISPQSDKFCETVKIIIRDQRSVLASAVLGLASIVCTGLVSYTTLPAIFIPFFLWMAG |
epithelial cell fate commitment glandular epithelial cell development intestinal epithelial cell development lung goblet cell differentiation negative regulation of cell fate commitment negative regulation of transcription by RNA polymerase II positive regulation of apoptotic process positive regulation of cell fate commitment positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription by RNA polymerase II | chromatin; nucleus | DNA-binding transcription factor activity, RNA polymerase II-specific sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | 3D-structure Activator Alternative splicing DNA-binding Nucleus Reference proteome Transcription Transcription regulation | MGSASPGLSS | MGSASPGLSSVSPSHLLLPPDTVSRTGLEKAAAGAVGLERRDWSPSPPATPEQGLSAFYLSYFDMLYPEDSSWAAKAPGASSREEPPEEPEQCPVIDSQAPAGSLDLVPGGLTLEEHSLEQVQSMVVGEVLKDIETACKLLNITADPMDWSPSNVQKWLLWTEHQYRLPPMGKAFQELAGKELCAMSEEQFRQRSPLGGDVLHAHLDIWKSAAWMKERTSPGAIHYCASTSEESWTDSEVDSSCSGQPIHLWQFLKELLLKPHSYGRFIRWLNKEKGIFKIEDSAQVARLWGIRKNRPAMNYDKLSRSIRQYYKKGIIRKPDISQRLVYQFVHPI | epithelial cell fate commitment glandular epithelial cell development intestinal epithelial cell development lung goblet cell differentiation negative regulation of cell fate commitment negative regulation of transcription by RNA polymerase II positive regulation of apoptotic process positive regulation of cell fate commitment positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II transcription by RNA polymerase II chromatin; nucleus DNA-binding transcription factor activity, RNA polymerase II-specific sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens 3D-structure Activator Alternative splicing DNA-binding Nucleus Reference proteome Transcription Transcription regulation MGSASPGLSS MGSASPGLSSVSPSHLLLPPDTVSRTGLEKAAAGAVGLERRDWSPSPPATPEQGLSAFYLSYFDMLYPEDSSWAAKAPGASSREEPPEEPEQCPVIDSQAPAGSLDLVPGGLTLEEHSLEQVQSMVVGEVLKDIETACKLLNITADPMDWSPSNVQKWLLWTEHQYRLPPMGKAFQELAGKELCAMSEEQFRQRSPLGGDVLHAHLDIWKSAAWMKERTSPGAIHYCASTSEESWTDSEVDSSCSGQPIHLWQFLKELLLKPHSYGRFIRWLNKEKGIFKIEDSAQVARLWGIRKNRPAMNYDKLSRSIRQYYKKGIIRKPDISQRLVYQFVHPI |
depyrimidination DNA repair response to estradiol | nuclear speck; nucleoplasm; nucleus | DNA binding DNA endonuclease activity DNA N-glycosylase activity pyrimidine-specific mismatch base pair DNA N-glycosylase activity satellite DNA binding | Homo sapiens | 3D-structure Alternative splicing Disease variant DNA damage DNA repair DNA-binding Hydrolase Nucleus Phosphoprotein Reference proteome | MGTTGLESLS | MGTTGLESLSLGDRGAAPTVTSSERLVPDPPNDLRKEDVAMELERVGEDEEQMMIKRSSECNPLLQEPIASAQFGATAGTECRKSVPCGWERVVKQRLFGKTAGRFDVYFISPQGLKFRSKSSLANYLHKNGETSLKPEDFDFTVLSKRGIKSRYKDCSMAALTSHLQNQSNNSNWNLRTRSKCKKDVFMPPSSSSELQESRGLSNFTSTHLLLKEDEGVDDVNFRKVRKPKGKVTILKGIPIKKTKKGCRKSCSGFVQSDSKRESVCNKADAESEPVAQKSQLDRTVCISDAGACGETLSVTSEENSLVKKKERSLSSGSNFCSEQKTSGIINKFCSAKDSEHNEKYEDTFLESEEIGTKVEVVERKEHLHTDILKRGSEMDNNCSPTRKDFTGEKIFQEDTIPRTQIERRKTSLYFSSKYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLSLS | depyrimidination DNA repair response to estradiol nuclear speck; nucleoplasm; nucleus DNA binding DNA endonuclease activity DNA N-glycosylase activity pyrimidine-specific mismatch base pair DNA N-glycosylase activity satellite DNA binding Homo sapiens 3D-structure Alternative splicing Disease variant DNA damage DNA repair DNA-binding Hydrolase Nucleus Phosphoprotein Reference proteome MGTTGLESLS MGTTGLESLSLGDRGAAPTVTSSERLVPDPPNDLRKEDVAMELERVGEDEEQMMIKRSSECNPLLQEPIASAQFGATAGTECRKSVPCGWERVVKQRLFGKTAGRFDVYFISPQGLKFRSKSSLANYLHKNGETSLKPEDFDFTVLSKRGIKSRYKDCSMAALTSHLQNQSNNSNWNLRTRSKCKKDVFMPPSSSSELQESRGLSNFTSTHLLLKEDEGVDDVNFRKVRKPKGKVTILKGIPIKKTKKGCRKSCSGFVQSDSKRESVCNKADAESEPVAQKSQLDRTVCISDAGACGETLSVTSEENSLVKKKERSLSSGSNFCSEQKTSGIINKFCSAKDSEHNEKYEDTFLESEEIGTKVEVVERKEHLHTDILKRGSEMDNNCSPTRKDFTGEKIFQEDTIPRTQIERRKTSLYFSSKYNKEALSPPRRKAFKKWTPPRSPFNLVQETLFHDPWKLLIATIFLNRTSGKMAIPVLWKFLEKYPSAEVARTADWRDVSELLKPLGLYDLRAKTIVKFSDEYLTKQWKYPIELHGIGKYGNDSYRIFCVNEWKQVHPEDHKLNKYHDWLWENHEKLSLS |
endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport protein transport retrograde transport, endosome to Golgi vesicle fusion | cis-Golgi network; cytosol; Golgi apparatus; Golgi medial cisterna; Golgi membrane; membrane; SNARE complex; transport vesicle | SNAP receptor activity | Homo sapiens | Acetylation Alternative splicing Coiled coil ER-Golgi transport Golgi apparatus Membrane Phosphoprotein Protein transport Reference proteome Transmembrane Transmembrane helix Transport | MAAGTSSYWE | MAAGTSSYWEDLRKQARQLENELDLKLVSFSKLCTSYSHSSTRDGRRDRYSSDTTPLLNGSSQDRMFETMAIEIEQLLARLTGVNDKMAEYTNSAGVPSLNAALMHTLQRHRDILQDYTHEFHKTKANFMAIRERENLMGSVRKDIESYKSGSGVNNRRTELFLKEHDHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQRINLRKRRDSLILGGVIGICTILLLLYAFH | endoplasmic reticulum to Golgi vesicle-mediated transport intra-Golgi vesicle-mediated transport protein transport retrograde transport, endosome to Golgi vesicle fusion cis-Golgi network; cytosol; Golgi apparatus; Golgi medial cisterna; Golgi membrane; membrane; SNARE complex; transport vesicle SNAP receptor activity Homo sapiens Acetylation Alternative splicing Coiled coil ER-Golgi transport Golgi apparatus Membrane Phosphoprotein Protein transport Reference proteome Transmembrane Transmembrane helix Transport MAAGTSSYWE MAAGTSSYWEDLRKQARQLENELDLKLVSFSKLCTSYSHSSTRDGRRDRYSSDTTPLLNGSSQDRMFETMAIEIEQLLARLTGVNDKMAEYTNSAGVPSLNAALMHTLQRHRDILQDYTHEFHKTKANFMAIRERENLMGSVRKDIESYKSGSGVNNRRTELFLKEHDHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQRINLRKRRDSLILGGVIGICTILLLLYAFH |
DNA repair DNA replication DNA replication-dependent chromatin disassembly internal peptidyl-lysine acetylation natural killer cell differentiation negative regulation of DNA-templated transcription positive regulation of DNA replication positive regulation of DNA-templated transcription, elongation positive regulation of hematopoietic stem cell proliferation positive regulation of protein localization to nucleus positive regulation of transcription by RNA polymerase II regulation of cell cycle regulation of cell growth regulation of DNA biosynthetic process regulation of DNA replication regulation of DNA-templated DNA replication initiation regulation of DNA-templated transcription regulation of nucleotide-excision repair response to actinomycin D response to anisomycin response to dithiothreitol response to hydroxyurea response to sorbitol stress-activated protein kinase signaling cascade transcription initiation-coupled chromatin remodeling | chromosome; chromosome, centromeric region; cytosol; histone acetyltransferase complex; histone H3-K14 acetyltransferase complex; nucleoplasm; nucleus; site of DNA damage | DNA replication origin binding histone acetyltransferase activity histone H3K14 acetyltransferase activity histone H3K23 acetyltransferase activity histone H3K4 acetyltransferase activity histone H4 acetyltransferase activity histone H4K12 acetyltransferase activity histone H4K5 acetyltransferase activity histone H4K8 acetyltransferase activity transcription coregulator activity zinc ion binding | Homo sapiens | 3D-structure Acetylation Acyltransferase Alternative splicing Centromere Chromatin regulator Chromosome Cytoplasm DNA damage DNA repair DNA replication Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Transferase Ubl conjugation Zinc Zinc-finger | MPRRKRNAGS | MPRRKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTRSSARLSQSSQDSSPVRNLQSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGSETEQVVDFSDRETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTPPKGT | DNA repair DNA replication DNA replication-dependent chromatin disassembly internal peptidyl-lysine acetylation natural killer cell differentiation negative regulation of DNA-templated transcription positive regulation of DNA replication positive regulation of DNA-templated transcription, elongation positive regulation of hematopoietic stem cell proliferation positive regulation of protein localization to nucleus positive regulation of transcription by RNA polymerase II regulation of cell cycle regulation of cell growth regulation of DNA biosynthetic process regulation of DNA replication regulation of DNA-templated DNA replication initiation regulation of DNA-templated transcription regulation of nucleotide-excision repair response to actinomycin D response to anisomycin response to dithiothreitol response to hydroxyurea response to sorbitol stress-activated protein kinase signaling cascade transcription initiation-coupled chromatin remodeling chromosome; chromosome, centromeric region; cytosol; histone acetyltransferase complex; histone H3-K14 acetyltransferase complex; nucleoplasm; nucleus; site of DNA damage DNA replication origin binding histone acetyltransferase activity histone H3K14 acetyltransferase activity histone H3K23 acetyltransferase activity histone H3K4 acetyltransferase activity histone H4 acetyltransferase activity histone H4K12 acetyltransferase activity histone H4K5 acetyltransferase activity histone H4K8 acetyltransferase activity transcription coregulator activity zinc ion binding Homo sapiens 3D-structure Acetylation Acyltransferase Alternative splicing Centromere Chromatin regulator Chromosome Cytoplasm DNA damage DNA repair DNA replication Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation Transferase Ubl conjugation Zinc Zinc-finger MPRRKRNAGS MPRRKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTRSSARLSQSSQDSSPVRNLQSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGSETEQVVDFSDRETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTPPKGT |
cell population proliferation cellular response to hydrogen peroxide immune response inflammatory response interleukin-18-mediated signaling pathway neutrophil activation positive regulation of natural killer cell mediated cytotoxicity positive regulation of NF-kappaB transcription factor activity | interleukin-18 receptor complex; plasma membrane | coreceptor activity interleukin-18 receptor activity NAD(P)+ nucleosidase activity NAD+ nucleotidase, cyclic ADP-ribose generating | Homo sapiens | 3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein Hydrolase Immunoglobulin domain Inflammatory response Membrane NAD Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix | MLCLGWIFLW | MLCLGWIFLWLVAGERIKGFNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW | cell population proliferation cellular response to hydrogen peroxide immune response inflammatory response interleukin-18-mediated signaling pathway neutrophil activation positive regulation of natural killer cell mediated cytotoxicity positive regulation of NF-kappaB transcription factor activity interleukin-18 receptor complex; plasma membrane coreceptor activity interleukin-18 receptor activity NAD(P)+ nucleosidase activity NAD+ nucleotidase, cyclic ADP-ribose generating Homo sapiens 3D-structure Alternative splicing Cell membrane Disulfide bond Glycoprotein Hydrolase Immunoglobulin domain Inflammatory response Membrane NAD Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix MLCLGWIFLW MLCLGWIFLWLVAGERIKGFNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW |
aerobic respiration inorganic anion transport regulation of cellular response to oxidative stress | mitochondrial inner membrane; mitochondrion; plasma membrane | chloride transmembrane transporter activity protein homodimerization activity proton transmembrane transporter activity solute:inorganic anion antiporter activity transmembrane transporter activity | Homo sapiens | Alternative splicing Membrane Mitochondrion Mitochondrion inner membrane Reference proteome Repeat Transmembrane Transmembrane helix Transport | MGIFPGIILI | MGIFPGIILIFLRVKFATAAVIVSGHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRLQI | aerobic respiration inorganic anion transport regulation of cellular response to oxidative stress mitochondrial inner membrane; mitochondrion; plasma membrane chloride transmembrane transporter activity protein homodimerization activity proton transmembrane transporter activity solute:inorganic anion antiporter activity transmembrane transporter activity Homo sapiens Alternative splicing Membrane Mitochondrion Mitochondrion inner membrane Reference proteome Repeat Transmembrane Transmembrane helix Transport MGIFPGIILI MGIFPGIILIFLRVKFATAAVIVSGHQKSTTVSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRAAIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQRAIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRLQI |
cellular response to calcium ion myoblast fusion potassium ion transmembrane transport potassium ion transport regulation of cell population proliferation regulation of membrane potential | axon; dendrite; early endosome membrane; intracellular membrane-bounded organelle; nuclear inner membrane; perikaryon; plasma membrane; postsynaptic density membrane; presynaptic membrane; voltage-gated potassium channel complex | calmodulin binding delayed rectifier potassium channel activity phosphatidylinositol bisphosphate binding | Homo sapiens | 3D-structure Alternative splicing Calmodulin-binding Cell membrane Cell projection Disease variant Endosome Epilepsy Glycoprotein Intellectual disability Ion channel Ion transport Lipid-binding Membrane Nucleus Phosphoprotein Postsynaptic cell membrane Potassium Potassium channel Potassium transport Reference proteome Synapse Transmembrane Transmembrane helix Transport Voltage-gated channel | MTMAGGRRGL | MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFGAS | cellular response to calcium ion myoblast fusion potassium ion transmembrane transport potassium ion transport regulation of cell population proliferation regulation of membrane potential axon; dendrite; early endosome membrane; intracellular membrane-bounded organelle; nuclear inner membrane; perikaryon; plasma membrane; postsynaptic density membrane; presynaptic membrane; voltage-gated potassium channel complex calmodulin binding delayed rectifier potassium channel activity phosphatidylinositol bisphosphate binding Homo sapiens 3D-structure Alternative splicing Calmodulin-binding Cell membrane Cell projection Disease variant Endosome Epilepsy Glycoprotein Intellectual disability Ion channel Ion transport Lipid-binding Membrane Nucleus Phosphoprotein Postsynaptic cell membrane Potassium Potassium channel Potassium transport Reference proteome Synapse Transmembrane Transmembrane helix Transport Voltage-gated channel MTMAGGRRGL MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFGAS |
behavioral fear response cAMP catabolic process negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of steroid hormone biosynthetic process neuromuscular process controlling balance operant conditioning signal transduction visual learning | cytosol | 3',5'-cyclic-AMP phosphodiesterase activity metal ion binding | Homo sapiens | Alternative splicing cAMP Cushing syndrome Disease variant Hydrolase Metal-binding Phosphoprotein Reference proteome | MGCAPSIHVS | MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASGPPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS | behavioral fear response cAMP catabolic process negative regulation of insulin secretion involved in cellular response to glucose stimulus negative regulation of steroid hormone biosynthetic process neuromuscular process controlling balance operant conditioning signal transduction visual learning cytosol 3',5'-cyclic-AMP phosphodiesterase activity metal ion binding Homo sapiens Alternative splicing cAMP Cushing syndrome Disease variant Hydrolase Metal-binding Phosphoprotein Reference proteome MGCAPSIHVS MGCAPSIHVSQSGVIYCRDSDESSSPRQTTSVSQGPAAPLPGLFVQTDAADAIPPSRASGPPSVARVRRARTELGSGSSAGSAAPAATTSRGRRRHCCSSAEAETQTCYTSVKQVSSAEVRIGPMRLTQDPIQVLLIFAKEDSQSDGFWWACDRAGYRCNIARTPESALECFLDKHHEIIVIDHRQTQNFDAEAVCRSIRATNPSEHTVILAVVSRVSDDHEEASVLPLLHAGFNRRFMENSSIIACYNELIQIEHGEVRSQFKLRACNSVFTALDHCHEAIEITSDDHVIQYVNPAFERMMGYHKGELLGKELADLPKSDKNRADLLDTINTCIKKGKEWQGVYYARRKSGDSIQQHVKITPVIGQGGKIRHFVSLKKLCCTTDNNKQIHKIHRDSGDNSQTEPHSFRYKNRRKESIDVKSISSRGSDAPSLQNRRYPSMARIHSMTIEAPITKVINIINAAQENSPVTVAEALDRVLEILRTTELYSPQLGTKDEDPHTSDLVGGLMTDGLRRLSGNEYVFTKNVHQSHSHLAMPITINDVPPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQVIEANYHSSNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGRTNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIIDMVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADVANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFAHLPALMQHLADNYKHWKTLDDLKCKSLRLPSDS |
inorganic cation transmembrane transport serotonin receptor signaling pathway | cell surface; neuron projection; plasma membrane; postsynaptic membrane; serotonin-activated cation-selective channel complex; synapse | acetylcholine-gated monoatomic cation-selective channel activity serotonin-gated monoatomic cation channel activity | Homo sapiens | Alternative splicing Cell membrane Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Membrane Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport | MLSSVMAPLW | MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALWGGV | inorganic cation transmembrane transport serotonin receptor signaling pathway cell surface; neuron projection; plasma membrane; postsynaptic membrane; serotonin-activated cation-selective channel complex; synapse acetylcholine-gated monoatomic cation-selective channel activity serotonin-gated monoatomic cation channel activity Homo sapiens Alternative splicing Cell membrane Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Membrane Postsynaptic cell membrane Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport MLSSVMAPLW MLSSVMAPLWACILVAAGILATDTHHPQDSALYHLSKQLLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSSMFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQSSAGGFAQIQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVFKTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQEQPFLCLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEVWSQLQSISNYLQTQDQTDQQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALWGGV |
cell-matrix adhesion negative regulation of smooth muscle cell apoptotic process | extracellular region; extracellular space; plasma membrane; side of membrane | laminin binding | Homo sapiens | 3D-structure Cell membrane Direct protein sequencing Glycoprotein GPI-anchor Lipoprotein Membrane Reference proteome Repeat Signal | MDPARKAGAQ | MDPARKAGAQAMIWTAGWLLLLLLRGGAQALECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLTSRALDPAGNESAYPPNGVECYSCVGLSREACQGTSPPVVSCYNASDHVYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGSCCQGSRCNSDLRNKTYFSPRIPPLVRLPPPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPTSQTPRQGVEHEASRDEEPRLTGGAAGHQDRSNSGQYPAKGGPQQPHNKGCVAPTAGLAALLLAVAAGVLL | cell-matrix adhesion negative regulation of smooth muscle cell apoptotic process extracellular region; extracellular space; plasma membrane; side of membrane laminin binding Homo sapiens 3D-structure Cell membrane Direct protein sequencing Glycoprotein GPI-anchor Lipoprotein Membrane Reference proteome Repeat Signal MDPARKAGAQ MDPARKAGAQAMIWTAGWLLLLLLRGGAQALECYSCVQKADDGCSPNKMKTVKCAPGVDVCTEAVGAVETIHGQFSLAVRGCGSGLPGKNDRGLDLHGLLAFIQLQQCAQDRCNAKLNLTSRALDPAGNESAYPPNGVECYSCVGLSREACQGTSPPVVSCYNASDHVYKGCFDGNVTLTAANVTVSLPVRGCVQDEFCTRDGVTGPGFTLSGSCCQGSRCNSDLRNKTYFSPRIPPLVRLPPPEPTTVASTTSVTTSTSAPVRPTSTTKPMPAPTSQTPRQGVEHEASRDEEPRLTGGAAGHQDRSNSGQYPAKGGPQQPHNKGCVAPTAGLAALLLAVAAGVLL |
autophagosome assembly calcium ion transport carbohydrate phosphorylation dephosphorylation glial cell proliferation glycogen biosynthetic process glycogen metabolic process habituation L-glutamate transmembrane transport mitochondrion organization negative regulation of cell cycle negative regulation of dephosphorylation negative regulation of gene expression negative regulation of peptidyl-serine phosphorylation negative regulation of phosphatase activity peptidyl-tyrosine dephosphorylation positive regulation of macroautophagy proteasome-mediated ubiquitin-dependent protein catabolic process protein dephosphorylation regulation of cell growth regulation of proteasomal protein catabolic process regulation of protein import into nucleus regulation of protein localization to plasma membrane regulation of protein ubiquitination Wnt signaling pathway | cytoplasm; cytoplasmic side of rough endoplasmic reticulum membrane; cytosol; dendrite; nucleoplasm; nucleus; perikaryon; plasma membrane | carbohydrate binding carbohydrate phosphatase activity glycogen (starch) synthase activity glycogen binding myosin phosphatase activity phosphatase activity protein dimerization activity protein homodimerization activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity starch binding | Homo sapiens | 3D-structure Alternative initiation Alternative splicing Autophagy Carbohydrate metabolism Cell membrane Cytoplasm Disease variant Endoplasmic reticulum Epilepsy Glycogen metabolism Glycogen storage disease Hydrolase Membrane Neurodegeneration Nucleus Phosphoprotein Protein phosphatase Reference proteome Ubl conjugation | MRFRFGVVVP | MRFRFGVVVPPAVAGARPELLVVGSRPELGRWEPRGAVRLRPAGTAAGDGALALQEPGLWLGEVELAAEEAAQDGAEPGRVDTFWYKFLKREPGGELSWEGNGPHHDRCCTYNENNLVDGVYCLPIGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEEALARAQEDFFQKFGKVRSSVCSL | autophagosome assembly calcium ion transport carbohydrate phosphorylation dephosphorylation glial cell proliferation glycogen biosynthetic process glycogen metabolic process habituation L-glutamate transmembrane transport mitochondrion organization negative regulation of cell cycle negative regulation of dephosphorylation negative regulation of gene expression negative regulation of peptidyl-serine phosphorylation negative regulation of phosphatase activity peptidyl-tyrosine dephosphorylation positive regulation of macroautophagy proteasome-mediated ubiquitin-dependent protein catabolic process protein dephosphorylation regulation of cell growth regulation of proteasomal protein catabolic process regulation of protein import into nucleus regulation of protein localization to plasma membrane regulation of protein ubiquitination Wnt signaling pathway cytoplasm; cytoplasmic side of rough endoplasmic reticulum membrane; cytosol; dendrite; nucleoplasm; nucleus; perikaryon; plasma membrane carbohydrate binding carbohydrate phosphatase activity glycogen (starch) synthase activity glycogen binding myosin phosphatase activity phosphatase activity protein dimerization activity protein homodimerization activity protein serine/threonine phosphatase activity protein tyrosine phosphatase activity protein tyrosine/serine/threonine phosphatase activity starch binding Homo sapiens 3D-structure Alternative initiation Alternative splicing Autophagy Carbohydrate metabolism Cell membrane Cytoplasm Disease variant Endoplasmic reticulum Epilepsy Glycogen metabolism Glycogen storage disease Hydrolase Membrane Neurodegeneration Nucleus Phosphoprotein Protein phosphatase Reference proteome Ubl conjugation MRFRFGVVVP MRFRFGVVVPPAVAGARPELLVVGSRPELGRWEPRGAVRLRPAGTAAGDGALALQEPGLWLGEVELAAEEAAQDGAEPGRVDTFWYKFLKREPGGELSWEGNGPHHDRCCTYNENNLVDGVYCLPIGHWIEATGHTNEMKHTTDFYFNIAGHQAMHYSRILPNIWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEEALARAQEDFFQKFGKVRSSVCSL |
potassium ion export across plasma membrane potassium ion import across plasma membrane potassium ion transmembrane transport potassium ion transport regulation of resting membrane potential stabilization of membrane potential | monoatomic ion channel complex; plasma membrane | outward rectifier potassium channel activity potassium channel activity potassium ion leak channel activity | Homo sapiens | Disulfide bond Glycoprotein Ion channel Ion transport Membrane Phosphoprotein Potassium Potassium channel Potassium transport Reference proteome Transmembrane Transmembrane helix Transport Voltage-gated channel | MVDRGPLLTS | MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKILEVVSDAAGQGVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPFVFMVTEGWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQVKGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLVPLVVYSKNRVPTLEEVSQTLRSKGHVSRSPDEEAVARAPEDSSPAPEVFMNQLDRISEECEPWDAQDYHPLIFQDASITFVNTEAGLSDEETSKSSLEDNLAGEESPQQGAEAKAPLNMGEFPSSSESTFTSTESELSVPYEQLMNEYNKANSPKGT | potassium ion export across plasma membrane potassium ion import across plasma membrane potassium ion transmembrane transport potassium ion transport regulation of resting membrane potential stabilization of membrane potential monoatomic ion channel complex; plasma membrane outward rectifier potassium channel activity potassium channel activity potassium ion leak channel activity Homo sapiens Disulfide bond Glycoprotein Ion channel Ion transport Membrane Phosphoprotein Potassium Potassium channel Potassium transport Reference proteome Transmembrane Transmembrane helix Transport Voltage-gated channel MVDRGPLLTS MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKILEVVSDAAGQGVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPFVFMVTEGWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQVKGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLVPLVVYSKNRVPTLEEVSQTLRSKGHVSRSPDEEAVARAPEDSSPAPEVFMNQLDRISEECEPWDAQDYHPLIFQDASITFVNTEAGLSDEETSKSSLEDNLAGEESPQQGAEAKAPLNMGEFPSSSESTFTSTESELSVPYEQLMNEYNKANSPKGT |
cholesterol transport COPII-coated vesicle budding endoplasmic reticulum membrane organization endoplasmic reticulum organization endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum unfolded protein response endoplasmic reticulum-plasma membrane tethering intracellular calcium ion homeostasis IRE1-mediated unfolded protein response modulation by host of viral RNA genome replication negative regulation by host of viral genome replication negative regulation by virus of viral protein levels in host cell positive regulation by host of viral genome replication positive regulation of viral genome replication suppression of viral release by host viral release from host cell | cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; plasma membrane | beta-tubulin binding cadherin binding enzyme binding FFAT motif binding microtubule binding protein heterodimerization activity protein homodimerization activity | Homo sapiens | 3D-structure Acetylation Alternative splicing Amyotrophic lateral sclerosis Coiled coil Direct protein sequencing Disease variant Endoplasmic reticulum Host-virus interaction Isopeptide bond Membrane Neurodegeneration Phosphoprotein Reference proteome Transmembrane Transmembrane helix Ubl conjugation Unfolded protein response | MAKVEQVLSL | MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEVQRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIGKIAL | cholesterol transport COPII-coated vesicle budding endoplasmic reticulum membrane organization endoplasmic reticulum organization endoplasmic reticulum to Golgi vesicle-mediated transport endoplasmic reticulum unfolded protein response endoplasmic reticulum-plasma membrane tethering intracellular calcium ion homeostasis IRE1-mediated unfolded protein response modulation by host of viral RNA genome replication negative regulation by host of viral genome replication negative regulation by virus of viral protein levels in host cell positive regulation by host of viral genome replication positive regulation of viral genome replication suppression of viral release by host viral release from host cell cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; plasma membrane beta-tubulin binding cadherin binding enzyme binding FFAT motif binding microtubule binding protein heterodimerization activity protein homodimerization activity Homo sapiens 3D-structure Acetylation Alternative splicing Amyotrophic lateral sclerosis Coiled coil Direct protein sequencing Disease variant Endoplasmic reticulum Host-virus interaction Isopeptide bond Membrane Neurodegeneration Phosphoprotein Reference proteome Transmembrane Transmembrane helix Ubl conjugation Unfolded protein response MAKVEQVLSL MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIISTTASKTETPIVSKSLSSSLDDTEVKKVMEECKRLQGEVQRLREENKQFKEEDGLRMRKTVQSNSPISALAPTGKEEGLSTRLLALVVLFFIVGVIIGKIAL |
cell differentiation cellular response to calcium ion intracellular signal transduction negative regulation of Ras protein signal transduction positive regulation of dendrite extension signal transduction | cytosol | GTPase activator activity metal ion binding phospholipid binding | Homo sapiens | Alternative splicing Calcium Differentiation GTPase activation Metal-binding Reference proteome Repeat Zinc Zinc-finger | MAKSSSLNVR | MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGDCRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLADLDRAHEEFQQQERGKAALGPLGP | cell differentiation cellular response to calcium ion intracellular signal transduction negative regulation of Ras protein signal transduction positive regulation of dendrite extension signal transduction cytosol GTPase activator activity metal ion binding phospholipid binding Homo sapiens Alternative splicing Calcium Differentiation GTPase activation Metal-binding Reference proteome Repeat Zinc Zinc-finger MAKSSSLNVR MAKSSSLNVRVVEGRALPAKDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLDFHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSVQMLEDGQGRCLRCHVLQARDLAPRDISGTSDPFARVFWGSQSLETSTIKKTRFPHWDEVLELREMPGAPSPLRVELWDWDMVGKNDFLGMVEFSPKTLQQKPPKGWFRLLPFPRAEEDSGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESVQGPAEEDTASPLALLEELTLGDCRQDLATKLVKLFLGRGLAGRFLDYLTRREVARTMDPNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRISFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAEHQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQLGQGKELWMAPLHPFLLQCVSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKRKEEPAGLATRFAFKKRYVWLSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHVMQVVTQDGTGALHTTYLQCKNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCLQAERSAAGCSRTHSAVTLGDWSDPLDPDAEAQTVYRQLLLGRDQLRLKLLEDSNMDTTLEADTGACPEVLARQRAATARLLEVLADLDRAHEEFQQQERGKAALGPLGP |
anterograde axonal transport anterograde synaptic vesicle transport autophagosome maturation endosome to lysosome transport intracellular protein transport late endosome to lysosome transport lysosomal lumen acidification lysosome localization lysosome organization melanosome organization negative regulation of neuron projection development neuron cellular homeostasis neuron projection development neurotransmitter secretion organelle transport along microtubule positive regulation of late endosome to lysosome transport protein maturation protein-containing complex localization regulation of endosome size regulation of lysosome size regulation of protein binding regulation of synaptic vesicle exocytosis retrograde axonal transport synaptic vesicle exocytosis synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle maturation synaptic vesicle transport terminal button organization | acrosomal vesicle; axon cytoplasm; BLOC-1 complex; BORC complex; cytoplasmic side of lysosomal membrane; cytosol; Golgi membrane; manchette; perinuclear region of cytoplasm; secretory granule; synapse; synaptic vesicle; synaptic vesicle membrane | SNARE binding | Homo sapiens | Acetylation Coiled coil Cytoplasm Cytoplasmic vesicle Exocytosis Golgi apparatus Host-virus interaction Lysosome Membrane Phosphoprotein Reference proteome Synapse | MAGAGSAAVS | MAGAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGIYPPGSPGK | anterograde axonal transport anterograde synaptic vesicle transport autophagosome maturation endosome to lysosome transport intracellular protein transport late endosome to lysosome transport lysosomal lumen acidification lysosome localization lysosome organization melanosome organization negative regulation of neuron projection development neuron cellular homeostasis neuron projection development neurotransmitter secretion organelle transport along microtubule positive regulation of late endosome to lysosome transport protein maturation protein-containing complex localization regulation of endosome size regulation of lysosome size regulation of protein binding regulation of synaptic vesicle exocytosis retrograde axonal transport synaptic vesicle exocytosis synaptic vesicle fusion to presynaptic active zone membrane synaptic vesicle maturation synaptic vesicle transport terminal button organization acrosomal vesicle; axon cytoplasm; BLOC-1 complex; BORC complex; cytoplasmic side of lysosomal membrane; cytosol; Golgi membrane; manchette; perinuclear region of cytoplasm; secretory granule; synapse; synaptic vesicle; synaptic vesicle membrane SNARE binding Homo sapiens Acetylation Coiled coil Cytoplasm Cytoplasmic vesicle Exocytosis Golgi apparatus Host-virus interaction Lysosome Membrane Phosphoprotein Reference proteome Synapse MAGAGSAAVS MAGAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGIYPPGSPGK |
cell-cell signaling transmembrane receptor protein tyrosine kinase signaling pathway | cell surface; focal adhesion; plasma membrane | structural molecule activity | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Immunoglobulin domain Membrane Phosphoprotein Reference proteome Signal Transmembrane Transmembrane helix | MAASAGAGAV | MAASAGAGAVIAAPDSRRWLWSVLAAALGLLTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQAPRKSPSDTEGLVKSLPSGSHQGPVIYAQLDHSGGHHSDKINKSESVVYADIRKN | cell-cell signaling transmembrane receptor protein tyrosine kinase signaling pathway cell surface; focal adhesion; plasma membrane structural molecule activity Homo sapiens 3D-structure Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein Immunoglobulin domain Membrane Phosphoprotein Reference proteome Signal Transmembrane Transmembrane helix MAASAGAGAV MAASAGAGAVIAAPDSRRWLWSVLAAALGLLTAGVSALEVYTPKEIFVANGTQGKLTCKFKSTSTTGGLTSVSWSFQPEGADTTVSFFHYSQGQVYLGNYPPFKDRISWAGDLDKKDASINIENMQFIHNGTYICDVKNPPDIVVQPGHIRLYVVEKENLPVFPVWVVVGIVTAVVLGLTLLISMILAVLYRRKNSKRDYTGCSTSESLSPVKQAPRKSPSDTEGLVKSLPSGSHQGPVIYAQLDHSGGHHSDKINKSESVVYADIRKN |
protein folding | endoplasmic reticulum | calcium ion binding peptidyl-prolyl cis-trans isomerase activity | Homo sapiens | Alternative splicing Calcium Endoplasmic reticulum Glycoprotein Isomerase Metal-binding Phosphoprotein Reference proteome Repeat Rotamase Signal | MAFRGWRPPP | MAFRGWRPPPPPLLLLLLWVTGQAAPVAGLGSDAELQIERRFVPDECPRTVRSGDFVRYHYVGTFPDGQKFDSSYDRDSTFNVFVGKGQLITGMDQALVGMCVNERRFVKIPPKLAYGNEGVSGVIPPNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLDGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFLAYGEDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDTYIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRGNIPGSAVLVFDIHVIDFHNPSDSISITSHYKPPDCSVLSKKGDYLKYHYNASLLDGTLLDSTWNLGKTYNIVLGSGQVVLGMDMGLREMCVGEKRTVIIPPHLGYGEAGVDGEVPGSAVLVFDIELLELVAGLPEGYMFIWNGEVSPNLFEEIDKDGNGEVLLEEFSEYIHAQVASGKGKLAPGFDAELIVKNMFTNQDRNGDGKVTAEEFKLKDQEAKHDEL | protein folding endoplasmic reticulum calcium ion binding peptidyl-prolyl cis-trans isomerase activity Homo sapiens Alternative splicing Calcium Endoplasmic reticulum Glycoprotein Isomerase Metal-binding Phosphoprotein Reference proteome Repeat Rotamase Signal MAFRGWRPPP MAFRGWRPPPPPLLLLLLWVTGQAAPVAGLGSDAELQIERRFVPDECPRTVRSGDFVRYHYVGTFPDGQKFDSSYDRDSTFNVFVGKGQLITGMDQALVGMCVNERRFVKIPPKLAYGNEGVSGVIPPNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLDGTLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFLAYGEDGDGKDIPGQASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLLDGTLFDSSYSRNRTFDTYIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRGNIPGSAVLVFDIHVIDFHNPSDSISITSHYKPPDCSVLSKKGDYLKYHYNASLLDGTLLDSTWNLGKTYNIVLGSGQVVLGMDMGLREMCVGEKRTVIIPPHLGYGEAGVDGEVPGSAVLVFDIELLELVAGLPEGYMFIWNGEVSPNLFEEIDKDGNGEVLLEEFSEYIHAQVASGKGKLAPGFDAELIVKNMFTNQDRNGDGKVTAEEFKLKDQEAKHDEL |
mRNA splice site recognition regulation of alternative mRNA splicing, via spliceosome regulation of heart contraction RNA processing | cytoplasm; Flemming body; intracellular membrane-bounded organelle; nucleoplasm; nucleus; ribonucleoprotein complex | mRNA 3'-UTR binding pre-mRNA binding RNA binding | Homo sapiens | 3D-structure Alternative splicing Cytoplasm Disease variant Epilepsy Intellectual disability mRNA processing Nucleus Reference proteome Repeat Repressor RNA-binding | MRCPKSAVTM | MRCPKSAVTMRNEELLLSNGTANKMNGALDHSDQPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNLTGLGGLTPQYLALLQQATSSSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATSTNANPLSTTSSALGALTSPVAASTPNSTAGAAMNSLTSLGTLQGLAGATVGLNNINALAGMAALNGGLGATGLTNGTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSKPY | mRNA splice site recognition regulation of alternative mRNA splicing, via spliceosome regulation of heart contraction RNA processing cytoplasm; Flemming body; intracellular membrane-bounded organelle; nucleoplasm; nucleus; ribonucleoprotein complex mRNA 3'-UTR binding pre-mRNA binding RNA binding Homo sapiens 3D-structure Alternative splicing Cytoplasm Disease variant Epilepsy Intellectual disability mRNA processing Nucleus Reference proteome Repeat Repressor RNA-binding MRCPKSAVTM MRCPKSAVTMRNEELLLSNGTANKMNGALDHSDQPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQQLAQQMQQLNTATWGNLTGLGGLTPQYLALLQQATSSSNLGAFSGIQQMAGMNALQLQNLATLAAAAAAAQTSATSTNANPLSTTSSALGALTSPVAASTPNSTAGAAMNSLTSLGTLQGLAGATVGLNNINALAGMAALNGGLGATGLTNGTAGTMDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSKPY |
3'-phosphoadenosine 5'-phosphosulfate biosynthetic process blood coagulation bone development hormone metabolic process phosphorylation sulfate assimilation | cytosol | adenylylsulfate kinase activity ATP binding nucleotidyltransferase activity sulfate adenylyltransferase (ATP) activity | Homo sapiens | 3D-structure Alternative splicing ATP-binding Disease variant Dwarfism Kinase Multifunctional enzyme Nucleotide-binding Nucleotidyltransferase Reference proteome Transferase | MSGIKKQKTE | MSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPYTIIKDIHELFVPENKLDHVRAEAETLPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVMHFDTLLDDGVINMSIPIVLPVSAEDKTRLEGCSKFVLAHGGRRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDLQVLEKIRWNDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGVLDPKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPARHNEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLEKN | 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process blood coagulation bone development hormone metabolic process phosphorylation sulfate assimilation cytosol adenylylsulfate kinase activity ATP binding nucleotidyltransferase activity sulfate adenylyltransferase (ATP) activity Homo sapiens 3D-structure Alternative splicing ATP-binding Disease variant Dwarfism Kinase Multifunctional enzyme Nucleotide-binding Nucleotidyltransferase Reference proteome Transferase MSGIKKQKTE MSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPYTIIKDIHELFVPENKLDHVRAEAETLPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVMHFDTLLDDGVINMSIPIVLPVSAEDKTRLEGCSKFVLAHGGRRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDLQVLEKIRWNDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGVLDPKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPARHNEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLEKN |
apoptotic process involved in development brain development cell proliferation in forebrain epithelial cell maturation eye development forebrain dorsal/ventral pattern formation lens development in camera-type eye lens fiber cell apoptotic process lens fiber cell differentiation negative regulation of DNA-templated transcription negative regulation of neuron differentiation neuroblast differentiation neuroblast migration optic vesicle morphogenesis pituitary gland development proximal/distal axis specification regulation of cell cycle phase transition regulation of cell population proliferation regulation of neural precursor cell proliferation regulation of neural retina development regulation of neuroblast proliferation regulation of transcription by RNA polymerase II telencephalon development telencephalon regionalization visual perception | chromatin; nucleus; transcription regulator complex | DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding signaling receptor binding transcription corepressor binding | Homo sapiens | Developmental protein Disease variant DNA-binding Holoprosencephaly Homeobox Nucleus Reference proteome Repressor Transcription Transcription regulation | MVFRSPLDLY | MVFRSPLDLYSSHFLLPNFADSHHRSILLASSGGGNGAGGGGGAGGGSGGGNGAGGGGAGGAGGGGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSECDV | apoptotic process involved in development brain development cell proliferation in forebrain epithelial cell maturation eye development forebrain dorsal/ventral pattern formation lens development in camera-type eye lens fiber cell apoptotic process lens fiber cell differentiation negative regulation of DNA-templated transcription negative regulation of neuron differentiation neuroblast differentiation neuroblast migration optic vesicle morphogenesis pituitary gland development proximal/distal axis specification regulation of cell cycle phase transition regulation of cell population proliferation regulation of neural precursor cell proliferation regulation of neural retina development regulation of neuroblast proliferation regulation of transcription by RNA polymerase II telencephalon development telencephalon regionalization visual perception chromatin; nucleus; transcription regulator complex DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding signaling receptor binding transcription corepressor binding Homo sapiens Developmental protein Disease variant DNA-binding Holoprosencephaly Homeobox Nucleus Reference proteome Repressor Transcription Transcription regulation MVFRSPLDLY MVFRSPLDLYSSHFLLPNFADSHHRSILLASSGGGNGAGGGGGAGGGSGGGNGAGGGGAGGAGGGGGGGSRAPPEELSMFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSECDV |
autophagosome assembly autophagy cellular response to hyperoxia cellular response to nitrogen starvation cellular response to starvation defense response to virus macroautophagy mitophagy nucleophagy piecemeal microautophagy of the nucleus positive regulation of apoptotic process positive regulation of protein catabolic process positive regulation of protein modification process protein lipidation protein modification by small protein conjugation protein transport regulation of circadian rhythm rhythmic process | axoneme; cytoplasm; cytosol; extracellular region; ficolin-1-rich granule lumen; phagophore assembly site; secretory granule lumen | Atg12 activating enzyme activity Atg8 activating enzyme activity protein homodimerization activity | Homo sapiens | Acetylation Alternative splicing Autophagy Biological rhythms Cytoplasm Disease variant Neurodegeneration Phosphoprotein Protein transport Reference proteome Transport Ubl conjugation pathway | MAAATGDPGL | MAAATGDPGLSKLQFAPFSSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLPARLTLEFSAFDMSAPTPARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGTALENPVLLNKFLLLTFADLKKYHFYYWFCYPALCLPESLPLIQGPVGLDQRFSLKQIEALECAYDNLCQTEGVTALPYFLIKYDENMVLVSLLKHYSDFFQGQRTKITIGVYDPCNLAQYPGWPLRNFLVLAAHRWSSSFQSVEVVCFRDRTMQGARDVAHSIIFEVKLPEMAFSPDCPKAVGWEKNQKGGMGPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADRLQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRESRWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEGGYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYEREGFNFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDDETI | autophagosome assembly autophagy cellular response to hyperoxia cellular response to nitrogen starvation cellular response to starvation defense response to virus macroautophagy mitophagy nucleophagy piecemeal microautophagy of the nucleus positive regulation of apoptotic process positive regulation of protein catabolic process positive regulation of protein modification process protein lipidation protein modification by small protein conjugation protein transport regulation of circadian rhythm rhythmic process axoneme; cytoplasm; cytosol; extracellular region; ficolin-1-rich granule lumen; phagophore assembly site; secretory granule lumen Atg12 activating enzyme activity Atg8 activating enzyme activity protein homodimerization activity Homo sapiens Acetylation Alternative splicing Autophagy Biological rhythms Cytoplasm Disease variant Neurodegeneration Phosphoprotein Protein transport Reference proteome Transport Ubl conjugation pathway MAAATGDPGL MAAATGDPGLSKLQFAPFSSALDVGFWHELTQKKLNEYRLDEAPKDIKGYYYNGDSAGLPARLTLEFSAFDMSAPTPARCCPAIGTLYNTNTLESFKTADKKLLLEQAANEIWESIKSGTALENPVLLNKFLLLTFADLKKYHFYYWFCYPALCLPESLPLIQGPVGLDQRFSLKQIEALECAYDNLCQTEGVTALPYFLIKYDENMVLVSLLKHYSDFFQGQRTKITIGVYDPCNLAQYPGWPLRNFLVLAAHRWSSSFQSVEVVCFRDRTMQGARDVAHSIIFEVKLPEMAFSPDCPKAVGWEKNQKGGMGPRMVNLSECMDPKRLAESSVDLNLKLMCWRLVPTLDLDKVVSVKCLLLGAGTLGCNVARTLMGWGVRHITFVDNAKISYSNPVRQPLYEFEDCLGGGKPKALAAADRLQKIFPGVNARGFNMSIPMPGHPVNFSSVTLEQARRDVEQLEQLIESHDVVFLLMDTRESRWLPAVIAASKRKLVINAALGFDTFVVMRHGLKKPKQQGAGDLCPNHPVASADLLGSSLFANIPGYKLGCYFCNDVVAPGDSTRDRTLDQQCTVSRPGLAVIAGALAVELMVSVLQHPEGGYAIASSSDDRMNEPPTSLGLVPHQIRGFLSRFDNVLPVSLAFDKCTACSSKVLDQYEREGFNFLAKVFNSSHSFLEDLTGLTLLHQETQAAEIWDMSDDETI |
positive regulation of DNA-templated transcription positive regulation of interleukin-1 beta production positive regulation of keratinocyte differentiation positive regulation of retinoic acid receptor signaling pathway response to growth hormone response to organophosphorus response to retinoic acid | cytoplasm; cytosol; plasma membrane; PML body | DNA binding interleukin-1 binding NACHT domain binding transferase activity zinc ion binding | Homo sapiens | 3D-structure Alternative splicing Coiled coil Cytoplasm Metal-binding Phosphoprotein Reference proteome Repeat Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger | MAELDLMAPG | MAELDLMAPGPLPRATAQPPAPLSPDSGSPSPDSGSASPVEEEDVGSSEKLGRETEEQDSDSAEQGDPAGEGKEVLCDFCLDDTRRVKAVKSCLTCMVNYCEEHLQPHQVNIKLQSHLLTEPVKDHNWRYCPAHHSPLSAFCCPDQQCICQDCCQEHSGHTIVSLDAARRDKEAELQCTQLDLERKLKLNENAISRLQANQKSVLVSVSEVKAVAEMQFGELLAAVRKAQANVMLFLEEKEQAALSQANGIKAHLEYRSAEMEKSKQELERMAAISNTVQFLEEYCKFKNTEDITFPSVYVGLKDKLSGIRKVITESTVHLIQLLENYKKKLQEFSKEEEYDIRTQVSAVVQRKYWTSKPEPSTREQFLQYAYDITFDPDTAHKYLRLQEENRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVEIFGAGTYVGLTCKGIDRKGEERNSCISGNNFSWSLQWNGKEFTAWYSDMETPLKAGPFRRLGVYIDFPGGILSFYGVEYDTMTLVHKFACKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAPSLVGTAP | positive regulation of DNA-templated transcription positive regulation of interleukin-1 beta production positive regulation of keratinocyte differentiation positive regulation of retinoic acid receptor signaling pathway response to growth hormone response to organophosphorus response to retinoic acid cytoplasm; cytosol; plasma membrane; PML body DNA binding interleukin-1 binding NACHT domain binding transferase activity zinc ion binding Homo sapiens 3D-structure Alternative splicing Coiled coil Cytoplasm Metal-binding Phosphoprotein Reference proteome Repeat Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger MAELDLMAPG MAELDLMAPGPLPRATAQPPAPLSPDSGSPSPDSGSASPVEEEDVGSSEKLGRETEEQDSDSAEQGDPAGEGKEVLCDFCLDDTRRVKAVKSCLTCMVNYCEEHLQPHQVNIKLQSHLLTEPVKDHNWRYCPAHHSPLSAFCCPDQQCICQDCCQEHSGHTIVSLDAARRDKEAELQCTQLDLERKLKLNENAISRLQANQKSVLVSVSEVKAVAEMQFGELLAAVRKAQANVMLFLEEKEQAALSQANGIKAHLEYRSAEMEKSKQELERMAAISNTVQFLEEYCKFKNTEDITFPSVYVGLKDKLSGIRKVITESTVHLIQLLENYKKKLQEFSKEEEYDIRTQVSAVVQRKYWTSKPEPSTREQFLQYAYDITFDPDTAHKYLRLQEENRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVEIFGAGTYVGLTCKGIDRKGEERNSCISGNNFSWSLQWNGKEFTAWYSDMETPLKAGPFRRLGVYIDFPGGILSFYGVEYDTMTLVHKFACKFSEPVYAAFWLSKKENAIRIVDLGEEPEKPAPSLVGTAP |
phenylalanyl-tRNA aminoacylation tRNA aminoacylation for protein translation tRNA processing | cytoplasm; mitochondrial matrix; mitochondrion | ATP binding phenylalanine-tRNA ligase activity tRNA binding | Homo sapiens | 3D-structure Acetylation Aminoacyl-tRNA synthetase ATP-binding Disease variant Hereditary spastic paraplegia Ligase Mitochondrion Neurodegeneration Nucleotide-binding Primary mitochondrial disease Protein biosynthesis Reference proteome Transit peptide | MVGSALRRGA | MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVEFDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKYPAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRHMERTLSQREVRHIHQALQEAAVQLLGVEGRF | phenylalanyl-tRNA aminoacylation tRNA aminoacylation for protein translation tRNA processing cytoplasm; mitochondrial matrix; mitochondrion ATP binding phenylalanine-tRNA ligase activity tRNA binding Homo sapiens 3D-structure Acetylation Aminoacyl-tRNA synthetase ATP-binding Disease variant Hereditary spastic paraplegia Ligase Mitochondrion Neurodegeneration Nucleotide-binding Primary mitochondrial disease Protein biosynthesis Reference proteome Transit peptide MVGSALRRGA MVGSALRRGAHAYVYLVSKASHISRGHQHQAWGSRPPAAECATQRAPGSVVELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHFYKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLNRTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQHYPIFHQLEAVRLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVEFDLKQTLTRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQLVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSNINQKVKFQPLSKYPAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVDLIDKFVHPKTHKTSHCYRITYRHMERTLSQREVRHIHQALQEAAVQLLGVEGRF |
B cell differentiation chromatin organization chromatin remodeling DNA-templated transcription double-strand break repair via classical nonhomologous end joining erythrocyte maturation fat cell differentiation negative regulation of androgen receptor signaling pathway negative regulation of DNA-templated transcription negative regulation of Notch signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of NF-kappaB transcription factor activity protein localization to nucleus regulation of alternative mRNA splicing, via spliceosome regulation of apoptotic process regulation of DNA-binding transcription factor activity regulation of glycolytic process regulation of transcription by RNA polymerase II regulation of transcription regulatory region DNA binding | cytoplasm; DNA-dependent protein kinase complex; nucleus; site of double-strand break | DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription repressor activity, RNA polymerase II-specific histone acetyltransferase binding metal ion binding nuclear androgen receptor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding SMAD binding transcription corepressor binding | Homo sapiens | 3D-structure Developmental protein Differentiation Disease variant DNA-binding Intellectual disability Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MAGGVDGPIG | MAGGVDGPIGIPFPDHSSDILSGLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALMDFAYTATLTVSTANVGDILSAARLLEIPAVSHVCADLLDRQILAADAGADAGQLDLVDQIDQRNLLRAKEYLEFFQSNPMNSLPPAAAAAAASFPWSAFGASDDDLDATKEAVAAAVAAVAAGDCNGLDFYGPGPPAERPPTGDGDEGDSNPGLWPERDEDAPTGGLFPPPVAPPAATQNGHYGRGGEEEAASLSEAAPEPGDSPGFLSGAAEGEDGDGPDVDGLAASTLLQQMMSSVGRAGAAAGDSDEESRADDKGVMDYYLKYFSGAHDGDVYPAWSQKVEKKIRAKAFQKCPICEKVIQGAGKLPRHIRTHTGEKPYECNICKVRFTRQDKLKVHMRKHTGEKPYLCQQCGAAFAHNYDLKNHMRVHTGLRPYQCDSCCKTFVRSDHLHRHLKKDGCNGVPSRRGRKPRVRGGAPDPSPGATATPGAPAQPSSPDARRNGQEKHFKDEDEDEDVASPDGLGRLNVAGAGGGGDSGGGPGAATDGNFTAGLA | B cell differentiation chromatin organization chromatin remodeling DNA-templated transcription double-strand break repair via classical nonhomologous end joining erythrocyte maturation fat cell differentiation negative regulation of androgen receptor signaling pathway negative regulation of DNA-templated transcription negative regulation of Notch signaling pathway negative regulation of transcription by RNA polymerase II negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of NF-kappaB transcription factor activity protein localization to nucleus regulation of alternative mRNA splicing, via spliceosome regulation of apoptotic process regulation of DNA-binding transcription factor activity regulation of glycolytic process regulation of transcription by RNA polymerase II regulation of transcription regulatory region DNA binding cytoplasm; DNA-dependent protein kinase complex; nucleus; site of double-strand break DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription repressor activity, RNA polymerase II-specific histone acetyltransferase binding metal ion binding nuclear androgen receptor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding SMAD binding transcription corepressor binding Homo sapiens 3D-structure Developmental protein Differentiation Disease variant DNA-binding Intellectual disability Isopeptide bond Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger MAGGVDGPIG MAGGVDGPIGIPFPDHSSDILSGLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALMDFAYTATLTVSTANVGDILSAARLLEIPAVSHVCADLLDRQILAADAGADAGQLDLVDQIDQRNLLRAKEYLEFFQSNPMNSLPPAAAAAAASFPWSAFGASDDDLDATKEAVAAAVAAVAAGDCNGLDFYGPGPPAERPPTGDGDEGDSNPGLWPERDEDAPTGGLFPPPVAPPAATQNGHYGRGGEEEAASLSEAAPEPGDSPGFLSGAAEGEDGDGPDVDGLAASTLLQQMMSSVGRAGAAAGDSDEESRADDKGVMDYYLKYFSGAHDGDVYPAWSQKVEKKIRAKAFQKCPICEKVIQGAGKLPRHIRTHTGEKPYECNICKVRFTRQDKLKVHMRKHTGEKPYLCQQCGAAFAHNYDLKNHMRVHTGLRPYQCDSCCKTFVRSDHLHRHLKKDGCNGVPSRRGRKPRVRGGAPDPSPGATATPGAPAQPSSPDARRNGQEKHFKDEDEDEDVASPDGLGRLNVAGAGGGGDSGGGPGAATDGNFTAGLA |
acylglycerol catabolic process axon guidance fatty acid metabolic process prostaglandin catabolic process protein depalmitoylation | cytoplasm; cytosol; extracellular exosome; Golgi stack; nucleoplasm | cadherin binding carboxylic ester hydrolase activity lysophospholipase activity palmitoyl-(protein) hydrolase activity | Homo sapiens | 3D-structure Cytoplasm Fatty acid metabolism Hydrolase Lipid metabolism Lipoprotein Palmitate Phosphoprotein Reference proteome | MCGNTMSVPL | MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV | acylglycerol catabolic process axon guidance fatty acid metabolic process prostaglandin catabolic process protein depalmitoylation cytoplasm; cytosol; extracellular exosome; Golgi stack; nucleoplasm cadherin binding carboxylic ester hydrolase activity lysophospholipase activity palmitoyl-(protein) hydrolase activity Homo sapiens 3D-structure Cytoplasm Fatty acid metabolism Hydrolase Lipid metabolism Lipoprotein Palmitate Phosphoprotein Reference proteome MCGNTMSVPL MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV |
developmental cell growth hematopoietic stem cell proliferation positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein targeting to mitochondrion protein K48-linked ubiquitination protein K63-linked ubiquitination protein polyubiquitination protein ubiquitination ubiquitin-dependent protein catabolic process | cytoplasm; nucleoplasm; nucleus; ubiquitin ligase complex | ubiquitin conjugating enzyme binding ubiquitin protein ligase activity ubiquitin-protein transferase activity zinc ion binding | Homo sapiens | 3D-structure Cytoplasm Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger | MSVDMNSQGS | MSVDMNSQGSDSNEEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALNEHMTSLASVLKVSHSVAKLILVNFHWQVSEILDRYKSNSAQLLVEARVQPNPSKHVPTSHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT | developmental cell growth hematopoietic stem cell proliferation positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of protein targeting to mitochondrion protein K48-linked ubiquitination protein K63-linked ubiquitination protein polyubiquitination protein ubiquitination ubiquitin-dependent protein catabolic process cytoplasm; nucleoplasm; nucleus; ubiquitin ligase complex ubiquitin conjugating enzyme binding ubiquitin protein ligase activity ubiquitin-protein transferase activity zinc ion binding Homo sapiens 3D-structure Cytoplasm Metal-binding Nucleus Phosphoprotein Reference proteome Repeat Transferase Ubl conjugation Ubl conjugation pathway Zinc Zinc-finger MSVDMNSQGS MSVDMNSQGSDSNEEDYDPNCEEEEEEEEDDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALNEHMTSLASVLKVSHSVAKLILVNFHWQVSEILDRYKSNSAQLLVEARVQPNPSKHVPTSHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT |
cell-cell signaling epidermis development epididymis development labyrinthine layer morphogenesis spongiotrophoblast differentiation trophoblast giant cell differentiation | connexin complex | gap junction channel activity | Homo sapiens | Cell junction Cell membrane Gap junction Membrane Reference proteome Transmembrane Transmembrane helix | MNWSIFEGLL | MNWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGCSNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREVQEKRHREAHGENSGRLYLNPGKKRGGLWWTYVCSLVFKASVDIAFLYVFHSFYPKYILPPVVKCHADPCPNIVDCFISKPSEKNIFTLFMVATAAICILLNLVELIYLVSKRCHECLAARKAQAMCTGHHPHGTTSSCKQDDLLSGDLIFLGSDSHPPLLPDRPRDHVKKTIL | cell-cell signaling epidermis development epididymis development labyrinthine layer morphogenesis spongiotrophoblast differentiation trophoblast giant cell differentiation connexin complex gap junction channel activity Homo sapiens Cell junction Cell membrane Gap junction Membrane Reference proteome Transmembrane Transmembrane helix MNWSIFEGLL MNWSIFEGLLSGVNKYSTAFGRIWLSLVFIFRVLVYLVTAERVWSDDHKDFDCNTRQPGCSNVCFDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREVQEKRHREAHGENSGRLYLNPGKKRGGLWWTYVCSLVFKASVDIAFLYVFHSFYPKYILPPVVKCHADPCPNIVDCFISKPSEKNIFTLFMVATAAICILLNLVELIYLVSKRCHECLAARKAQAMCTGHHPHGTTSSCKQDDLLSGDLIFLGSDSHPPLLPDRPRDHVKKTIL |
apoptotic process negative regulation of apoptotic process positive regulation of apoptotic process | cytoplasm; nucleoplasm | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | Homo sapiens | Alternative splicing Apoptosis Coiled coil Cytoplasm Reference proteome | MHSEAEESKE | MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDYTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKPHLQKLCDGINKMLDEENI | apoptotic process negative regulation of apoptotic process positive regulation of apoptotic process cytoplasm; nucleoplasm cysteine-type endopeptidase inhibitor activity involved in apoptotic process Homo sapiens Alternative splicing Apoptosis Coiled coil Cytoplasm Reference proteome MHSEAEESKE MHSEAEESKEVATDVFNSKNLAVQAQKKILGKMVSKSIATTLIDDTSSEVLDELYRVTREYTQNKKEAEKIIKNLIKTVIKLAILYRNNQFNQDELALMEKFKKKVHQLAMTVVSFHQVDYTFDRNVLSRLLNECREMLHQIIQRHLTAKSHGRVNNVFDHFSDCEFLAALYNPFGNFKPHLQKLCDGINKMLDEENI |
bone development cell adhesion cell-cell signaling glucose homeostasis negative regulation of chondrocyte differentiation negative regulation of fat cell differentiation osteoblast differentiation osteoclast differentiation positive regulation of inflammatory response positive regulation of osteoblast differentiation positive regulation of smooth muscle cell migration positive regulation of smooth muscle cell proliferation positive regulation of Wnt signaling pathway positive regulation of wound healing regulation of cytokine production signal transduction Wnt signaling pathway | cytosol; extracellular matrix; extracellular space | heparin binding integrin binding | Homo sapiens | Alternative splicing Cell adhesion Disulfide bond Glycoprotein Proto-oncogene Reference proteome Secreted Signal Wnt signaling pathway | MRWFLPWTLA | MRWFLPWTLAAVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFSEIAN | bone development cell adhesion cell-cell signaling glucose homeostasis negative regulation of chondrocyte differentiation negative regulation of fat cell differentiation osteoblast differentiation osteoclast differentiation positive regulation of inflammatory response positive regulation of osteoblast differentiation positive regulation of smooth muscle cell migration positive regulation of smooth muscle cell proliferation positive regulation of Wnt signaling pathway positive regulation of wound healing regulation of cytokine production signal transduction Wnt signaling pathway cytosol; extracellular matrix; extracellular space heparin binding integrin binding Homo sapiens Alternative splicing Cell adhesion Disulfide bond Glycoprotein Proto-oncogene Reference proteome Secreted Signal Wnt signaling pathway MRWFLPWTLA MRWFLPWTLAAVTAAAASTVLATALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFSEIAN |
cell adhesion cell-cell signaling negative regulation of angiogenesis negative regulation of cell population proliferation regulation of mitochondrial membrane potential regulation of reactive oxygen species biosynthetic process signal transduction | extracellular matrix; extracellular space; mitochondrion | growth factor activity heparin binding integrin binding | Homo sapiens | Alternative splicing Disease variant Disulfide bond Glycoprotein Growth factor Mitochondrion Reference proteome Secreted Signal | MQGLLFSTLL | MQGLLFSTLLLAGLAQFCCRVQGTGPLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLFIPKLAGSHCSGAKGGKKSDQSNCSLEPLLQQLSTSYKTMPAYRNLPLIWKKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQRNCREPGDIFSELKIL | cell adhesion cell-cell signaling negative regulation of angiogenesis negative regulation of cell population proliferation regulation of mitochondrial membrane potential regulation of reactive oxygen species biosynthetic process signal transduction extracellular matrix; extracellular space; mitochondrion growth factor activity heparin binding integrin binding Homo sapiens Alternative splicing Disease variant Disulfide bond Glycoprotein Growth factor Mitochondrion Reference proteome Secreted Signal MQGLLFSTLL MQGLLFSTLLLAGLAQFCCRVQGTGPLDTTPEGRPGEVSDAPQRKQFCHWPCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEICNEADLCDPHKGLYCDYSVDRPRYETGVCAYLVAVGCEFNQVHYHNGQVFQPNPLFSCLCVSGAIGCTPLFIPKLAGSHCSGAKGGKKSDQSNCSLEPLLQQLSTSYKTMPAYRNLPLIWKKKCLVQATKWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPCDSNILKTIKIPKGKTCQPTFQLSKAEKFVFSGCSSTQSYKPTFCGICLDKRCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQRNCREPGDIFSELKIL |
amacrine cell differentiation camera-type eye morphogenesis cell population proliferation mesoderm development metanephros development negative regulation of amacrine cell differentiation negative regulation of cell population proliferation nervous system development roof of mouth development skeletal system development SMAD protein signal transduction spinal cord anterior/posterior patterning type B pancreatic cell maturation ureteric bud development | extracellular space; intracellular membrane-bounded organelle; nucleoplasm; protein-containing complex | cytokine activity growth factor activity | Homo sapiens | 3D-structure Cleavage on pair of basic residues Cytokine Disease variant Disulfide bond Glycoprotein Growth factor Reference proteome Secreted Signal | MVLAAPLLLG | MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS | amacrine cell differentiation camera-type eye morphogenesis cell population proliferation mesoderm development metanephros development negative regulation of amacrine cell differentiation negative regulation of cell population proliferation nervous system development roof of mouth development skeletal system development SMAD protein signal transduction spinal cord anterior/posterior patterning type B pancreatic cell maturation ureteric bud development extracellular space; intracellular membrane-bounded organelle; nucleoplasm; protein-containing complex cytokine activity growth factor activity Homo sapiens 3D-structure Cleavage on pair of basic residues Cytokine Disease variant Disulfide bond Glycoprotein Growth factor Reference proteome Secreted Signal MVLAAPLLLG MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS |
alternative mRNA splicing, via spliceosome cellular response to heat intracellular protein transport mRNA 3'-splice site recognition mRNA splicing, via spliceosome RNA splicing RNA splicing, via transesterification reactions | catalytic step 2 spliceosome; cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; nuclear speck; nucleoplasm; nucleus; small nuclear ribonucleoprotein complex; spliceosomal complex | pre-mRNA 3'-splice site binding second spliceosomal transesterification activity zinc ion binding | Homo sapiens | 3D-structure Acetylation Cytoplasm Isopeptide bond Metal-binding mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Spliceosome Ubl conjugation Zinc Zinc-finger | MSATVVDAVN | MSATVVDAVNAAPLSGSKEMSLEEPKKMTREDWRKKKELEEQRKLGNAPAEVDEEGKDINPHIPQYISSVPWYIDPSKRPTLKHQRPQPEKQKQFSSSGEWYKRGVKENSIITKYRKGACENCGAMTHKKKDCFERPRRVGAKFTGTNIAPDEHVQPQLMFDYDGKRDRWNGYNPEEHMKIVEEYAKVDLAKRTLKAQKLQEELASGKLVEQANSPKHQWGEEEPNSQMEKDHNSEDEDEDKYADDIDMPGQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYANAGKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEAYDKGSEVHLQADPTKLELLYKSFKVKKEDFKEQQKESILEKYGGQEHLDAPPAELLLAQTEDYVEYSRHGTVIKGQERAVACSKYEEDVKIHNHTHIWGSYWKEGRWGYKCCHSFFKYSYCTGEAGKEIVNSEECIINEITGEESVKKPQTLMELHQEKLKEEKKKKKKKKKKHRKSSSDSDDEEKKHEKLKKALNAEEARLLHVKETMQIDERKRPYNSMYETREPTEEEMEAYRMKRQRPDDPMASFLGQ | alternative mRNA splicing, via spliceosome cellular response to heat intracellular protein transport mRNA 3'-splice site recognition mRNA splicing, via spliceosome RNA splicing RNA splicing, via transesterification reactions catalytic step 2 spliceosome; cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; nuclear speck; nucleoplasm; nucleus; small nuclear ribonucleoprotein complex; spliceosomal complex pre-mRNA 3'-splice site binding second spliceosomal transesterification activity zinc ion binding Homo sapiens 3D-structure Acetylation Cytoplasm Isopeptide bond Metal-binding mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Spliceosome Ubl conjugation Zinc Zinc-finger MSATVVDAVN MSATVVDAVNAAPLSGSKEMSLEEPKKMTREDWRKKKELEEQRKLGNAPAEVDEEGKDINPHIPQYISSVPWYIDPSKRPTLKHQRPQPEKQKQFSSSGEWYKRGVKENSIITKYRKGACENCGAMTHKKKDCFERPRRVGAKFTGTNIAPDEHVQPQLMFDYDGKRDRWNGYNPEEHMKIVEEYAKVDLAKRTLKAQKLQEELASGKLVEQANSPKHQWGEEEPNSQMEKDHNSEDEDEDKYADDIDMPGQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYANAGKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEAYDKGSEVHLQADPTKLELLYKSFKVKKEDFKEQQKESILEKYGGQEHLDAPPAELLLAQTEDYVEYSRHGTVIKGQERAVACSKYEEDVKIHNHTHIWGSYWKEGRWGYKCCHSFFKYSYCTGEAGKEIVNSEECIINEITGEESVKKPQTLMELHQEKLKEEKKKKKKKKKKHRKSSSDSDDEEKKHEKLKKALNAEEARLLHVKETMQIDERKRPYNSMYETREPTEEEMEAYRMKRQRPDDPMASFLGQ |
carbohydrate metabolic process glucosamine metabolic process hemopoiesis protein N-linked glycosylation protein O-linked glycosylation spermatogenesis UDP-N-acetylglucosamine biosynthetic process | cytosol | magnesium ion binding phosphoacetylglucosamine mutase activity | Homo sapiens | Acetylation Alternative splicing Carbohydrate metabolism Disease variant Isomerase Magnesium Metal-binding Phosphoprotein Reference proteome | MDLGAITKYS | MDLGAITKYSALHAKPNGLILQYGTAGFRTKAEHLDHVMFRMGLLAVLRSKQTKSTIGVMVTASHNPEEDNGVKLVDPLGEMLAPSWEEHATCLANAEEQDMQRVLIDISEKEAVNLQQDAFVVIGRDTRPSSEKLSQSVIDGVTVLGGQFHDYGLLTTPQLHYMVYCRNTGGRYGKATIEGYYQKLSKAFVELTKQASCSGDEYRSLKVDCANGIGALKLREMEHYFSQGLSVQLFNDGSKGKLNHLCGADFVKSHQKPPQGMEIKSNERCCSFDGDADRIVYYYHDADGHFHLIDGDKIATLISSFLKELLVEIGESLNIGVVQTAYANGSSTRYLEEVMKVPVYCTKTGVKHLHHKAQEFDIGVYFEANGHGTALFSTAVEMKIKQSAEQLEDKKRKAAKMLENIIDLFNQAAGDAISDMLVIEAILALKGLTVQQWDALYTDLPNRQLKVQVADRRVISTTDAERQAVTPPGLQEAINDLVKKYKLSRAFVRPSGTEDVVRVYAEADSQESADHLAHEVSLAVFQLAGGIGERPQPGF | carbohydrate metabolic process glucosamine metabolic process hemopoiesis protein N-linked glycosylation protein O-linked glycosylation spermatogenesis UDP-N-acetylglucosamine biosynthetic process cytosol magnesium ion binding phosphoacetylglucosamine mutase activity Homo sapiens Acetylation Alternative splicing Carbohydrate metabolism Disease variant Isomerase Magnesium Metal-binding Phosphoprotein Reference proteome MDLGAITKYS MDLGAITKYSALHAKPNGLILQYGTAGFRTKAEHLDHVMFRMGLLAVLRSKQTKSTIGVMVTASHNPEEDNGVKLVDPLGEMLAPSWEEHATCLANAEEQDMQRVLIDISEKEAVNLQQDAFVVIGRDTRPSSEKLSQSVIDGVTVLGGQFHDYGLLTTPQLHYMVYCRNTGGRYGKATIEGYYQKLSKAFVELTKQASCSGDEYRSLKVDCANGIGALKLREMEHYFSQGLSVQLFNDGSKGKLNHLCGADFVKSHQKPPQGMEIKSNERCCSFDGDADRIVYYYHDADGHFHLIDGDKIATLISSFLKELLVEIGESLNIGVVQTAYANGSSTRYLEEVMKVPVYCTKTGVKHLHHKAQEFDIGVYFEANGHGTALFSTAVEMKIKQSAEQLEDKKRKAAKMLENIIDLFNQAAGDAISDMLVIEAILALKGLTVQQWDALYTDLPNRQLKVQVADRRVISTTDAERQAVTPPGLQEAINDLVKKYKLSRAFVRPSGTEDVVRVYAEADSQESADHLAHEVSLAVFQLAGGIGERPQPGF |
carbohydrate metabolic process intestinal absorption kidney morphogenesis O-glycan processing protein O-linked glycosylation tissue morphogenesis | extracellular exosome; Golgi membrane; membrane | acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity acetylglucosaminyltransferase activity beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity | Homo sapiens | Disulfide bond Glycoprotein Glycosyltransferase Golgi apparatus Membrane Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix | MVQWKRLCQL | MVQWKRLCQLHYLWALGCYMLLATVALKLSFRLKCDSDHLGLESRESQSQYCRNILYNFLKLPAKRSINCSGVTRGDQEAVLQAILNNLEVKKKREPFTDTHYLSLTRDCEHFKAERKFIQFPLSKEEVEFPIAYSMVIHEKIENFERLLRAVYAPQNIYCVHVDEKSPETFKEAVKAIISCFPNVFIASKLVRVVYASWSRVQADLNCMEDLLQSSVPWKYFLNTCGTDFPIKSNAEMVQALKMLNGRNSMESEVPPKHKETRWKYHFEVVRDTLHLTNKKKDPPPYNLTMFTGNAYIVASRDFVQHVLKNPKSQQLIEWVKDTYSPDEHLWATLQRARWMPGSVPNHPKYDISDMTSIARLVKWQGHEGDIDKGAPYAPCSGIHQRAICVYGAGDLNWMLQNHHLLANKFDPKVDDNALQCLEEYLRYKAIYGTEL | carbohydrate metabolic process intestinal absorption kidney morphogenesis O-glycan processing protein O-linked glycosylation tissue morphogenesis extracellular exosome; Golgi membrane; membrane acetylgalactosaminyl-O-glycosyl-seryl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity acetylgalactosaminyl-O-glycosyl-threonyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity acetylglucosaminyltransferase activity beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity Homo sapiens Disulfide bond Glycoprotein Glycosyltransferase Golgi apparatus Membrane Reference proteome Signal-anchor Transferase Transmembrane Transmembrane helix MVQWKRLCQL MVQWKRLCQLHYLWALGCYMLLATVALKLSFRLKCDSDHLGLESRESQSQYCRNILYNFLKLPAKRSINCSGVTRGDQEAVLQAILNNLEVKKKREPFTDTHYLSLTRDCEHFKAERKFIQFPLSKEEVEFPIAYSMVIHEKIENFERLLRAVYAPQNIYCVHVDEKSPETFKEAVKAIISCFPNVFIASKLVRVVYASWSRVQADLNCMEDLLQSSVPWKYFLNTCGTDFPIKSNAEMVQALKMLNGRNSMESEVPPKHKETRWKYHFEVVRDTLHLTNKKKDPPPYNLTMFTGNAYIVASRDFVQHVLKNPKSQQLIEWVKDTYSPDEHLWATLQRARWMPGSVPNHPKYDISDMTSIARLVKWQGHEGDIDKGAPYAPCSGIHQRAICVYGAGDLNWMLQNHHLLANKFDPKVDDNALQCLEEYLRYKAIYGTEL |
Mo-molybdopterin cofactor biosynthetic process molybdopterin cofactor metabolic process protein urmylation tRNA thio-modification tRNA wobble position uridine thiolation tRNA wobble uridine modification | cytoplasm; cytosol | ATP binding metal ion binding molybdopterin-synthase adenylyltransferase activity molybdopterin-synthase sulfurtransferase activity nucleotidyltransferase activity sulfurtransferase activity thiosulfate sulfurtransferase activity URM1 activating enzyme activity | Homo sapiens | 3D-structure ATP-binding Cytoplasm Disulfide bond Metal-binding Molybdenum cofactor biosynthesis Multifunctional enzyme Nucleotide-binding Reference proteome Transferase tRNA processing Zinc | MASREEVLAL | MASREEVLALQAEVAQREEELNSLKQKLASALLAEQEPQPERLVPVSPLPPKAALSRDEILRYSRQLVLPELGVHGQLRLGTACVLIVGCGGLGCPLAQYLAAAGVGRLGLVDYDVVEMSNLARQVLHGEALAGQAKAFSAAASLRRLNSAVECVPYTQALTPATALDLVRRYDVVADCSDNVPTRYLVNDACVLAGRPLVSASALRFEGQITVYHYDGGPCYRCIFPQPPPAETVTNCADGGVLGVVTGVLGCLQALEVLKIAAGLGPSYSGSLLLFDALRGHFRSIRLRSRRLDCAACGERPTVTDLLDYEAFCGSSATDKCRSLQLLSPEERVSVTDYKRLLDSGAFHLLLDVRPQVEVDICRLPHALHIPLKHLERRDAESLKLLKEAIWEEKQGTQEGAAVPIYVICKLGNDSQKAVKILQSLSAAQELDPLTVRDVVGGLMAWAAKIDGTFPQY | Mo-molybdopterin cofactor biosynthetic process molybdopterin cofactor metabolic process protein urmylation tRNA thio-modification tRNA wobble position uridine thiolation tRNA wobble uridine modification cytoplasm; cytosol ATP binding metal ion binding molybdopterin-synthase adenylyltransferase activity molybdopterin-synthase sulfurtransferase activity nucleotidyltransferase activity sulfurtransferase activity thiosulfate sulfurtransferase activity URM1 activating enzyme activity Homo sapiens 3D-structure ATP-binding Cytoplasm Disulfide bond Metal-binding Molybdenum cofactor biosynthesis Multifunctional enzyme Nucleotide-binding Reference proteome Transferase tRNA processing Zinc MASREEVLAL MASREEVLALQAEVAQREEELNSLKQKLASALLAEQEPQPERLVPVSPLPPKAALSRDEILRYSRQLVLPELGVHGQLRLGTACVLIVGCGGLGCPLAQYLAAAGVGRLGLVDYDVVEMSNLARQVLHGEALAGQAKAFSAAASLRRLNSAVECVPYTQALTPATALDLVRRYDVVADCSDNVPTRYLVNDACVLAGRPLVSASALRFEGQITVYHYDGGPCYRCIFPQPPPAETVTNCADGGVLGVVTGVLGCLQALEVLKIAAGLGPSYSGSLLLFDALRGHFRSIRLRSRRLDCAACGERPTVTDLLDYEAFCGSSATDKCRSLQLLSPEERVSVTDYKRLLDSGAFHLLLDVRPQVEVDICRLPHALHIPLKHLERRDAESLKLLKEAIWEEKQGTQEGAAVPIYVICKLGNDSQKAVKILQSLSAAQELDPLTVRDVVGGLMAWAAKIDGTFPQY |
adaptive immune response angiogenesis associative learning cAMP-mediated signaling cellular response to cAMP establishment of endothelial barrier intracellular signal transduction negative regulation of syncytium formation by plasma membrane fusion positive regulation of angiogenesis positive regulation of GTPase activity positive regulation of protein export from nucleus positive regulation of stress fiber assembly positive regulation of syncytium formation by plasma membrane fusion Rap protein signal transduction Ras protein signal transduction regulation of actin cytoskeleton organization regulation of angiogenesis regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction signal transduction | endomembrane system; extracellular exosome; filopodium; lamellipodium; membrane; microvillus; plasma membrane | cAMP binding guanyl-nucleotide exchange factor activity protein domain specific binding | Homo sapiens | 3D-structure Alternative splicing Angiogenesis cAMP cAMP-binding Guanine-nucleotide releasing factor Membrane Nucleotide-binding Phosphoprotein Reference proteome | MKVGWPGESC | MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVRTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP | adaptive immune response angiogenesis associative learning cAMP-mediated signaling cellular response to cAMP establishment of endothelial barrier intracellular signal transduction negative regulation of syncytium formation by plasma membrane fusion positive regulation of angiogenesis positive regulation of GTPase activity positive regulation of protein export from nucleus positive regulation of stress fiber assembly positive regulation of syncytium formation by plasma membrane fusion Rap protein signal transduction Ras protein signal transduction regulation of actin cytoskeleton organization regulation of angiogenesis regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction signal transduction endomembrane system; extracellular exosome; filopodium; lamellipodium; membrane; microvillus; plasma membrane cAMP binding guanyl-nucleotide exchange factor activity protein domain specific binding Homo sapiens 3D-structure Alternative splicing Angiogenesis cAMP cAMP-binding Guanine-nucleotide releasing factor Membrane Nucleotide-binding Phosphoprotein Reference proteome MKVGWPGESC MKVGWPGESCWQVGLAVEDSPALGAPRVGALPDVVPEGTLLNMVLRRMHRPRSCSYQLLLEHQRPSCIQGLRWTPLTNSEESLDFSESLEQASTERVLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCCSGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPEPVRTHEMEEELAEAVALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILREDNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERASQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSAQLCAALLHHFHVEPAGGSEQERSTYVCNKRQQILRLVSQWVALYGSMLHTDPVATSFLQKLSDLVGRDTRLSNLLREQWPERRRCHRLENGCGNASPQMKARNLPVWLPNQDEPLPGSSCAIQVGDKVPYDICRPDHSVLTLQLPVTASVREVMAALAQEDGWTKGQVLVKVNSAGDAIGLQPDARGVATSLGLNERLFVVNPQEVHELIPHPDQLGPTVGSAEGLDLVSAKDLAGQLTDHDWSLFNSIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALAKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAARMLHHCRSHNPVPLSPLRSRVSHLHEDSQVARISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP |
blood vessel diameter maintenance chemical synaptic transmission muscle contraction regulation of blood pressure | extracellular region; extracellular space; synapse | hormone activity signaling receptor binding | Homo sapiens | 3D-structure Alternative splicing Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Reference proteome Secreted Signal | MYKLASCCLL | MYKLASCCLLFIGFLNPLLSLPLLDSREISFQLSAPHEDARLTPEELERASLLQILPEMLGAERGDILRKADSSTNIFNPRGNLRKFQDFSGQDPNILLSHLLARIWKPYKKRETPDCFWKYCV | blood vessel diameter maintenance chemical synaptic transmission muscle contraction regulation of blood pressure extracellular region; extracellular space; synapse hormone activity signaling receptor binding Homo sapiens 3D-structure Alternative splicing Cleavage on pair of basic residues Direct protein sequencing Disulfide bond Hormone Reference proteome Secreted Signal MYKLASCCLL MYKLASCCLLFIGFLNPLLSLPLLDSREISFQLSAPHEDARLTPEELERASLLQILPEMLGAERGDILRKADSSTNIFNPRGNLRKFQDFSGQDPNILLSHLLARIWKPYKKRETPDCFWKYCV |
spliceosomal tri-snRNP complex assembly | cytoplasm; cytosol; fibrillar center; nuclear speck; nucleoplasm; nucleus; U5 snRNP | ribonucleoprotein complex binding | Homo sapiens | 3D-structure Acetylation Cytoplasm Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Ubl conjugation | MPKRKVTFQG | MPKRKVTFQGVGDEEDEDEIIVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEEDDDDGGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWLDNIDWVKIRERPPGQRQASDSEEEDSLGQTSMSAQALLEGLLELLLPRETVAGALRRLGARGGGKGRKGPGQPSSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCQTLGPHNPTPPPSLDMFAEELAEEELETPTPTQRGEAESRGDGLVDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT | spliceosomal tri-snRNP complex assembly cytoplasm; cytosol; fibrillar center; nuclear speck; nucleoplasm; nucleus; U5 snRNP ribonucleoprotein complex binding Homo sapiens 3D-structure Acetylation Cytoplasm Isopeptide bond mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Ubl conjugation MPKRKVTFQG MPKRKVTFQGVGDEEDEDEIIVPKKKLVDPVAGSGGPGSRFKGKHSLDSDEEEDDDDGGSSKYDILASEDVEGQEAATLPSEGGVRITPFNLQEEMEEGHFDADGNYFLNRDAQIRDSWLDNIDWVKIRERPPGQRQASDSEEEDSLGQTSMSAQALLEGLLELLLPRETVAGALRRLGARGGGKGRKGPGQPSSPQRLDRLSGLADQMVARGNLGVYQETRERLAMRLKGLGCQTLGPHNPTPPPSLDMFAEELAEEELETPTPTQRGEAESRGDGLVDVMWEYKWENTGDAELYGPFTSAQMQTWVSEGYFPDGVYCRKLDPPGGQFYNSKRIDFDLYT |
positive regulation of gene expression positive regulation of transcription elongation by RNA polymerase II positive regulation of transcription initiation by RNA polymerase II regulation of transcription by RNA polymerase II RNA polymerase II preinitiation complex assembly transcription initiation at RNA polymerase II promoter | core mediator complex; mediator complex; nucleoplasm; nucleus | transcription coactivator activity transcription coregulator activity | Homo sapiens | 3D-structure Activator Alternative splicing Direct protein sequencing Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation | MTAAPASPQQ | MTAAPASPQQIRDRLLQAIDPQSNIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPAHQHEAALRGLAGATGSANGGAHNCRPEVGAAGPPRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPLPTNGISGSPESFASSLDGSGHAGPEGSRLERDENDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQSLYAPKGSVPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVCWLEQPESHQRLAGPGCKAGLSPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQQSRTELDKQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRQGARQLHVLVPQSPPTDLPGLTREVTQDDLDRIQASQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD | positive regulation of gene expression positive regulation of transcription elongation by RNA polymerase II positive regulation of transcription initiation by RNA polymerase II regulation of transcription by RNA polymerase II RNA polymerase II preinitiation complex assembly transcription initiation at RNA polymerase II promoter core mediator complex; mediator complex; nucleoplasm; nucleus transcription coactivator activity transcription coregulator activity Homo sapiens 3D-structure Activator Alternative splicing Direct protein sequencing Nucleus Phosphoprotein Reference proteome Transcription Transcription regulation MTAAPASPQQ MTAAPASPQQIRDRLLQAIDPQSNIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPAHQHEAALRGLAGATGSANGGAHNCRPEVGAAGPPRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPLPTNGISGSPESFASSLDGSGHAGPEGSRLERDENDKHSGKIPVNAVRPHTSSPGLGKPPGPCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQSLYAPKGSVPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVCWLEQPESHQRLAGPGCKAGLSPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQQSRTELDKQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRQGARQLHVLVPQSPPTDLPGLTREVTQDDLDRIQASQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD |
apoptotic process negative regulation of apoptotic process | extracellular region; extracellular space | signaling receptor activity | Homo sapiens | 3D-structure Apoptosis Direct protein sequencing Disulfide bond Glycoprotein Receptor Reference proteome Repeat Secreted Signal | MRALEGPGLS | MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDAETGERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMPGLERSVRERFLPVH | apoptotic process negative regulation of apoptotic process extracellular region; extracellular space signaling receptor activity Homo sapiens 3D-structure Apoptosis Direct protein sequencing Disulfide bond Glycoprotein Receptor Reference proteome Repeat Secreted Signal MRALEGPGLS MRALEGPGLSLLCLVLALPALLPVPAVRGVAETPTYPWRDAETGERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMPGLERSVRERFLPVH |
brain development cell differentiation central nervous system development negative regulation of DNA-templated transcription positive regulation of DNA-binding transcription factor activity positive regulation of DNA-templated transcription regulation of transcription by RNA polymerase II visual perception | cytoplasm; nuclear body; nucleoplasm; nucleus | chromatin DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding | Homo sapiens | Activator Cytoplasm Developmental protein Differentiation Disease variant DNA-binding Holoprosencephaly Isopeptide bond Metal-binding Neurogenesis Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger | MLLDAGPQFP | MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPEQHGPHGSQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGGGSGSGGAGGGSGGGSGSGGGGGGAGGGGGGSSGGGSGTAGGHSGLSSNFNEWYV | brain development cell differentiation central nervous system development negative regulation of DNA-templated transcription positive regulation of DNA-binding transcription factor activity positive regulation of DNA-templated transcription regulation of transcription by RNA polymerase II visual perception cytoplasm; nuclear body; nucleoplasm; nucleus chromatin DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Homo sapiens Activator Cytoplasm Developmental protein Differentiation Disease variant DNA-binding Holoprosencephaly Isopeptide bond Metal-binding Neurogenesis Nucleus Phosphoprotein Reference proteome Repeat Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger MLLDAGPQFP MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPEQHGPHGSQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGGGSGSGGAGGGSGGGSGSGGGGGGAGGGGGGSSGGGSGTAGGHSGLSSNFNEWYV |
anatomical structure morphogenesis cell differentiation entrainment of circadian clock negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II nervous system development positive regulation of transcription by RNA polymerase II regulation of neuron migration visual perception | chromatin; nucleus; transcription regulator complex | chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | DNA-binding Nucleus Reference proteome Repressor Transcription Transcription regulation | MSKPSDHIKR | MSKPSDHIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDRYVFPLPYLGDTDPLKAAGLPVGASDGLLSAPEKARAFLPPASAPYSLLDPAQFSSSAIQKMGEVPHTLATGALPYASTLGYQNGAFGSLSCPSQHTHTHPSPTNPGYVVPCNCTAWSASTLQPPVAYILFPGMTKTGIDPYSSAHATAM | anatomical structure morphogenesis cell differentiation entrainment of circadian clock negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II nervous system development positive regulation of transcription by RNA polymerase II regulation of neuron migration visual perception chromatin; nucleus; transcription regulator complex chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens DNA-binding Nucleus Reference proteome Repressor Transcription Transcription regulation MSKPSDHIKR MSKPSDHIKRPMNAFMVWSRGQRRKMAQENPKMHNSEISKRLGAEWKLLSEAEKRPYIDEAKRLRAQHMKEHPDYKYRPRRKPKNLLKKDRYVFPLPYLGDTDPLKAAGLPVGASDGLLSAPEKARAFLPPASAPYSLLDPAQFSSSAIQKMGEVPHTLATGALPYASTLGYQNGAFGSLSCPSQHTHTHPSPTNPGYVVPCNCTAWSASTLQPPVAYILFPGMTKTGIDPYSSAHATAM |
GPI anchor biosynthetic process preassembly of GPI anchor in ER membrane | cytosol; endoplasmic reticulum membrane; membrane; plasma membrane | mannose-ethanolamine phosphotransferase activity | Homo sapiens | Disease variant Endoplasmic reticulum Epilepsy Glycoprotein GPI-anchor biosynthesis Membrane Reference proteome Transferase Transmembrane Transmembrane helix | MLLFFTLGLL | MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIEQETLQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTTQLSSKSLFLIVLVISDIMALHFFFLVKDYGSWLDIGTSISHYVIVMSMTIFLVFLNGLAQLLTTKKLRLCGKPKSHFM | GPI anchor biosynthetic process preassembly of GPI anchor in ER membrane cytosol; endoplasmic reticulum membrane; membrane; plasma membrane mannose-ethanolamine phosphotransferase activity Homo sapiens Disease variant Endoplasmic reticulum Epilepsy Glycoprotein GPI-anchor biosynthesis Membrane Reference proteome Transferase Transmembrane Transmembrane helix MLLFFTLGLL MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSILLSLMSTYLLLSTGYEALFPLVLSCLMFVWINIEQETLQQSGVCCKQKLTSIQFSYNTDITQFRQLYLDDIRRAFFLVFFLVTAFFGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQLTTQLSSKSLFLIVLVISDIMALHFFFLVKDYGSWLDIGTSISHYVIVMSMTIFLVFLNGLAQLLTTKKLRLCGKPKSHFM |
cellular response to epidermal growth factor stimulus cellular response to tumor necrosis factor negative regulation of apoptotic process negative regulation of mRNA modification negative regulation of protein targeting to mitochondrion positive regulation of actin filament polymerization positive regulation of cell adhesion positive regulation of fibroblast migration positive regulation of peptidyl-serine phosphorylation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of stress fiber assembly protein folding protein localization to plasma membrane protein stabilization ruffle assembly | cytoplasm; cytosol; membrane; nucleus; plasma membrane | adenyl-nucleotide exchange factor activity protein-containing complex binding protein-folding chaperone binding RNA binding ubiquitin protein ligase binding | Homo sapiens | 3D-structure Alternative splicing Chaperone Cytoplasm Methylation Phosphoprotein Reference proteome | MSALRRSGYG | MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQPPYPSYNSNYWNSTARSRAPYPSTYPVRPELQGQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRSSGNSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLPHYPYGDGNRSVPQSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDLLDSQVQYSAEPQLYGNATSDHPNNQDQSSSLPEECVPSDESTPPSIKKIIHVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL | cellular response to epidermal growth factor stimulus cellular response to tumor necrosis factor negative regulation of apoptotic process negative regulation of mRNA modification negative regulation of protein targeting to mitochondrion positive regulation of actin filament polymerization positive regulation of cell adhesion positive regulation of fibroblast migration positive regulation of peptidyl-serine phosphorylation positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of stress fiber assembly protein folding protein localization to plasma membrane protein stabilization ruffle assembly cytoplasm; cytosol; membrane; nucleus; plasma membrane adenyl-nucleotide exchange factor activity protein-containing complex binding protein-folding chaperone binding RNA binding ubiquitin protein ligase binding Homo sapiens 3D-structure Alternative splicing Chaperone Cytoplasm Methylation Phosphoprotein Reference proteome MSALRRSGYG MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQPPYPSYNSNYWNSTARSRAPYPSTYPVRPELQGQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRSSGNSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLPHYPYGDGNRSVPQSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDLLDSQVQYSAEPQLYGNATSDHPNNQDQSSSLPEECVPSDESTPPSIKKIIHVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL |
positive regulation of ATP-dependent activity protein folding | cytosol; endoplasmic reticulum; extracellular exosome | ATPase activator activity cadherin binding Hsp90 protein binding protein-folding chaperone binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Chaperone Cytoplasm Endoplasmic reticulum Host-virus interaction Isopeptide bond Phosphoprotein Reference proteome Stress response Ubl conjugation | MAKWGEGDPR | MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTDKLKTLFLAVQVQNEEGKCEVTEVSKLDGEASINNRKGKLIFFYEWSVKLNWTGTSKSGVQYKGHVEIPNLSDENSVDEVEISVSLAKDEPDTNLVALMKEEGVKLLREAMGIYISTLKTEFTQGMILPTMNGESVDPVGQPALKTEERKAKPAPSKTQARPVGVKIPTCKITLKETFLTSPEELYRVFTTQELVQAFTHAPATLEADRGGKFHMVDGNVSGEFTDLVPEKHIVMKWRFKSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYGARLF | positive regulation of ATP-dependent activity protein folding cytosol; endoplasmic reticulum; extracellular exosome ATPase activator activity cadherin binding Hsp90 protein binding protein-folding chaperone binding Homo sapiens 3D-structure Acetylation Alternative splicing Chaperone Cytoplasm Endoplasmic reticulum Host-virus interaction Isopeptide bond Phosphoprotein Reference proteome Stress response Ubl conjugation MAKWGEGDPR MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTDKLKTLFLAVQVQNEEGKCEVTEVSKLDGEASINNRKGKLIFFYEWSVKLNWTGTSKSGVQYKGHVEIPNLSDENSVDEVEISVSLAKDEPDTNLVALMKEEGVKLLREAMGIYISTLKTEFTQGMILPTMNGESVDPVGQPALKTEERKAKPAPSKTQARPVGVKIPTCKITLKETFLTSPEELYRVFTTQELVQAFTHAPATLEADRGGKFHMVDGNVSGEFTDLVPEKHIVMKWRFKSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYGARLF |
in utero embryonic development intracellular phosphate ion homeostasis phosphate ion transport protein metabolic process response to estrogen sodium-dependent phosphate transport | apical plasma membrane; brush border; brush border membrane; membrane; plasma membrane; vesicle | phosphate ion binding sodium ion binding sodium:phosphate symporter activity | Homo sapiens | Alternative splicing Cell membrane Disease variant Disulfide bond Glycoprotein Ion transport Membrane Reference proteome Sodium Sodium transport Symport Transmembrane Transmembrane helix Transport | MAPWPELGDA | MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL | in utero embryonic development intracellular phosphate ion homeostasis phosphate ion transport protein metabolic process response to estrogen sodium-dependent phosphate transport apical plasma membrane; brush border; brush border membrane; membrane; plasma membrane; vesicle phosphate ion binding sodium ion binding sodium:phosphate symporter activity Homo sapiens Alternative splicing Cell membrane Disease variant Disulfide bond Glycoprotein Ion transport Membrane Reference proteome Sodium Sodium transport Symport Transmembrane Transmembrane helix Transport MAPWPELGDA MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL |
cholesterol efflux cholesterol homeostasis high-density lipoprotein particle assembly high-density lipoprotein particle clearance high-density lipoprotein particle remodeling lipoprotein metabolic process negative regulation of plasma lipoprotein oxidation reverse cholesterol transport | discoidal high-density lipoprotein particle; extracellular region; high-density lipoprotein particle; low-density lipoprotein particle; spherical high-density lipoprotein particle; very-low-density lipoprotein particle | antioxidant activity lipid transporter activity phospholipid binding | Homo sapiens | 3D-structure Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein HDL Lipid transport Reference proteome Secreted Signal Transport | MFHQIWAALL | MFHQIWAALLYFYGIILNSIYQCPEHSQLTTLGVDGKEFPEVHLGQWYFIAGAAPTKEELATFDPVDNIVFNMAAGSAPMQLHLRATIRMKDGLCVPRKWIYHLTEGSTDLRTEGRPDMKTELFSSSCPGGIMLNETGQGYQRFLLYNRSPHPPEKCVEEFKSLTSCLDSKAFLLTPRNQEACELSNN | cholesterol efflux cholesterol homeostasis high-density lipoprotein particle assembly high-density lipoprotein particle clearance high-density lipoprotein particle remodeling lipoprotein metabolic process negative regulation of plasma lipoprotein oxidation reverse cholesterol transport discoidal high-density lipoprotein particle; extracellular region; high-density lipoprotein particle; low-density lipoprotein particle; spherical high-density lipoprotein particle; very-low-density lipoprotein particle antioxidant activity lipid transporter activity phospholipid binding Homo sapiens 3D-structure Alternative splicing Direct protein sequencing Disulfide bond Glycoprotein HDL Lipid transport Reference proteome Secreted Signal Transport MFHQIWAALL MFHQIWAALLYFYGIILNSIYQCPEHSQLTTLGVDGKEFPEVHLGQWYFIAGAAPTKEELATFDPVDNIVFNMAAGSAPMQLHLRATIRMKDGLCVPRKWIYHLTEGSTDLRTEGRPDMKTELFSSSCPGGIMLNETGQGYQRFLLYNRSPHPPEKCVEEFKSLTSCLDSKAFLLTPRNQEACELSNN |
cell-cell signaling cellular response to glucose stimulus ear morphogenesis gap junction assembly gap junction-mediated intercellular transport inner ear development maintenance of blood-brain barrier negative regulation of cell population proliferation response to electrical stimulus response to lipopolysaccharide sensory perception of sound sinoatrial node development transmembrane transport | actin filament; apical plasma membrane; cell junction; connexin complex; gap junction | actin filament binding beta-tubulin binding gap junction channel activity gap junction channel activity involved in cell communication by electrical coupling microtubule binding | Homo sapiens | Cell junction Cell membrane Deafness Disease variant Ectodermal dysplasia Gap junction Hearing Membrane Non-syndromic deafness Palmoplantar keratoderma Reference proteome Transmembrane Transmembrane helix | MDWGTLHTFI | MDWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCKNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEKRNDFKDIEDIKKQKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISASVICMLLNVAELCYLLLKVCFRRSKRAQTQKNHPNHALKESKQNEMNELISDSGQNAITGFPS | cell-cell signaling cellular response to glucose stimulus ear morphogenesis gap junction assembly gap junction-mediated intercellular transport inner ear development maintenance of blood-brain barrier negative regulation of cell population proliferation response to electrical stimulus response to lipopolysaccharide sensory perception of sound sinoatrial node development transmembrane transport actin filament; apical plasma membrane; cell junction; connexin complex; gap junction actin filament binding beta-tubulin binding gap junction channel activity gap junction channel activity involved in cell communication by electrical coupling microtubule binding Homo sapiens Cell junction Cell membrane Deafness Disease variant Ectodermal dysplasia Gap junction Hearing Membrane Non-syndromic deafness Palmoplantar keratoderma Reference proteome Transmembrane Transmembrane helix MDWGTLHTFI MDWGTLHTFIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVWGDEQEDFVCNTLQPGCKNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHETTRKFRRGEKRNDFKDIEDIKKQKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNGYHLPWVLKCGIDPCPNLVDCFISRPTEKTVFTIFMISASVICMLLNVAELCYLLLKVCFRRSKRAQTQKNHPNHALKESKQNEMNELISDSGQNAITGFPS |
box H/ACA RNA 3'-end processing female gamete generation miRNA catabolic process ncRNA deadenylation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA poly(A) tail shortening polyadenylation-dependent snoRNA 3'-end processing positive regulation of telomerase activity positive regulation of telomere maintenance via telomerase regulation of telomerase RNA localization to Cajal body RNA modification telomerase RNA stabilization | cytoplasm; cytosol; glutamatergic synapse; nuclear speck; nucleolus; nucleus; postsynapse | cation binding metal ion binding mRNA 3'-UTR binding nuclease activity poly(A)-specific ribonuclease activity protein kinase binding RNA binding telomerase RNA binding | Homo sapiens | 3D-structure Acetylation Alternative splicing Cytoplasm Disease variant Dyskeratosis congenita Exonuclease Hydrolase Magnesium Metal-binding Nonsense-mediated mRNA decay Nuclease Nucleus Phosphoprotein Reference proteome RNA-binding | MEIIRSNFKS | MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVKIAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAGSISKNSPATLFEVPDTW | box H/ACA RNA 3'-end processing female gamete generation miRNA catabolic process ncRNA deadenylation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay nuclear-transcribed mRNA poly(A) tail shortening polyadenylation-dependent snoRNA 3'-end processing positive regulation of telomerase activity positive regulation of telomere maintenance via telomerase regulation of telomerase RNA localization to Cajal body RNA modification telomerase RNA stabilization cytoplasm; cytosol; glutamatergic synapse; nuclear speck; nucleolus; nucleus; postsynapse cation binding metal ion binding mRNA 3'-UTR binding nuclease activity poly(A)-specific ribonuclease activity protein kinase binding RNA binding telomerase RNA binding Homo sapiens 3D-structure Acetylation Alternative splicing Cytoplasm Disease variant Dyskeratosis congenita Exonuclease Hydrolase Magnesium Metal-binding Nonsense-mediated mRNA decay Nuclease Nucleus Phosphoprotein Reference proteome RNA-binding MEIIRSNFKS MEIIRSNFKSNLHKVYQAIEEADFFAIDGEFSGISDGPSVSALTNGFDTPEERYQKLKKHSMDFLLFQFGLCTFKYDYTDSKYITKSFNFYVFPKPFNRSSPDVKFVCQSSSIDFLASQGFDFNKVFRNGIPYLNQEEERQLREQYDEKRSQANGAGALSYVSPNTSKCPVTIPEDQKKFIDQVVEKIEDLLQSEENKNLDLEPCTGFQRKLIYQTLSWKYPKGIHVETLETEKKERYIVISKVDEEERKRREQQKHAKEQEELNDAVGFSRVIHAIANSGKLVIGHNMLLDVMHTVHQFYCPLPADLSEFKEMTTCVFPRLLDTKLMASTQPFKDIINNTSLAELEKRLKETPFNPPKVESAEGFPSYDTASEQLHEAGYDAYITGLCFISMANYLGSFLSPPKIHVSARSKLIEPFFNKLFLMRVMDIPYLNLEGPDLQPKRDHVLHVTFPKEWKTSDLYQLFSAFGNIQISWIDDTSAFVSLSQPEQVKIAVNTSKYAESYRIQTYAEYMGRKQEEKQIKRKWTEDSWKEADSKRLNPQCIPYTLQNHYYRNNSFTAPSTVGKRNLSPSQEEAGLEDGVSGEISDTELEQTDSCAEPLSEGRKKAKKLKRMKKELSPAGSISKNSPATLFEVPDTW |
cerebellar granule cell precursor proliferation chaperone-mediated protein complex assembly proteasome core complex assembly | cytoplasm; cytosol; endoplasmic reticulum; Golgi apparatus; nucleoplasm; nucleus; protein folding chaperone complex | molecular adaptor activity proteasome binding | Homo sapiens | Acetylation Alternative splicing Chaperone Cytoplasm Endoplasmic reticulum Phosphoprotein Reference proteome | MAATFFGEVV | MAATFFGEVVKAPCRAGTEDEEEEEEGRRETPEDREVRLQLARKREVRLLRRQTKTSLEVSLLEKYPCSKFIIAIGNNAVAFLSSFVMNSGVWEEVGCAKLWNEWCRTTDTTHLSSTEAFCVFYHLKSNPSVFLCQCSCYVAEDQQYQWLEKVFGSCPRKNMQITILTCRHVTDYKTSESTGSLPSPFLRALKTQNFKDSACCPLLEQPNIVHDLPAAVLSYCQVWKIPAILYLCYTDVMKLDLITVEAFKPILSTRSLKGLVKNIPQSTEILKKLMTTNEIQSNIYT | cerebellar granule cell precursor proliferation chaperone-mediated protein complex assembly proteasome core complex assembly cytoplasm; cytosol; endoplasmic reticulum; Golgi apparatus; nucleoplasm; nucleus; protein folding chaperone complex molecular adaptor activity proteasome binding Homo sapiens Acetylation Alternative splicing Chaperone Cytoplasm Endoplasmic reticulum Phosphoprotein Reference proteome MAATFFGEVV MAATFFGEVVKAPCRAGTEDEEEEEEGRRETPEDREVRLQLARKREVRLLRRQTKTSLEVSLLEKYPCSKFIIAIGNNAVAFLSSFVMNSGVWEEVGCAKLWNEWCRTTDTTHLSSTEAFCVFYHLKSNPSVFLCQCSCYVAEDQQYQWLEKVFGSCPRKNMQITILTCRHVTDYKTSESTGSLPSPFLRALKTQNFKDSACCPLLEQPNIVHDLPAAVLSYCQVWKIPAILYLCYTDVMKLDLITVEAFKPILSTRSLKGLVKNIPQSTEILKKLMTTNEIQSNIYT |
extracellular matrix organization | collagen-containing extracellular matrix; extracellular region; matrilin complex | calcium ion binding | Homo sapiens | Alternative splicing Coiled coil Disulfide bond EGF-like domain Glycoprotein Reference proteome Repeat Secreted Signal | MRGLLCWPVL | MRGLLCWPVLLLLLQPWETQLQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQSRLCGKDQCAEGGHGCQHQCVNAWAMFHCTCNPGYKLAADNKSCLAIDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENLRGSICPEEGISAGTELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDLENQLANQK | extracellular matrix organization collagen-containing extracellular matrix; extracellular region; matrilin complex calcium ion binding Homo sapiens Alternative splicing Coiled coil Disulfide bond EGF-like domain Glycoprotein Reference proteome Repeat Secreted Signal MRGLLCWPVL MRGLLCWPVLLLLLQPWETQLQLTGPRCHTGPLDLVFVIDSSRSVRPFEFETMRQFLMGLLRGLNVGPNATRVGVIQYSSQVQSVFPLRAFSRREDMERAIRDLVPLAQGTMTGLAIQYAMNVAFSVAEGARPPEERVPRVAVIVTDGRPQDRVAEVAAQARARGIEIYAVGVQRADVGSLRAMASPPLDEHVFLVESFDLIQEFGLQFQSRLCGKDQCAEGGHGCQHQCVNAWAMFHCTCNPGYKLAADNKSCLAIDLCAEGTHGCEHHCVNSPGSYFCHCQVGFVLQQDQRSCRAIDYCSFGNHSCQHECVSTPGGPRCHCREGHDLQPDGRSCQVRDLCNGVDHGCEFQCVSEGLSYRCLCPEGRQLQADGKSCNRCREGHVDLVLLVDGSKSVRPQNFELVKRFVNQIVDFLDVSPEGTRVGLVQFSSRVRTEFPLGRYGTAAEVKQAVLAVEYMERGTMTGLALRHMVEHSFSEAQGARPRALNVPRVGLVFTDGRSQDDISVWAARAKEEGIVMYAVGVGKAVEAELREIASEPAELHVSYAPDFGTMTHLLENLRGSICPEEGISAGTELRSPCECESLVEFQGRTLGALESLTLNLAQLTARLEDLENQLANQK |
androgen metabolic process apoptotic signaling pathway ceramide metabolic process estrogen metabolic process face morphogenesis fatty acid metabolic process fibroblast migration hemopoiesis kidney development Leydig cell differentiation luteinization platelet-derived growth factor receptor signaling pathway post-embryonic development regulation of multicellular organism growth roof of mouth development skeletal system morphogenesis spermatogenesis sphingolipid catabolic process sphingolipid metabolic process vasculogenesis | endoplasmic reticulum; endoplasmic reticulum membrane | pyridoxal phosphate binding sphinganine-1-phosphate aldolase activity | Homo sapiens | 3D-structure Acetylation Apoptosis Disease variant Endoplasmic reticulum Lipid metabolism Lyase Membrane Nitration Phosphoprotein Pyridoxal phosphate Reference proteome Signal-anchor Sphingolipid metabolism Transmembrane Transmembrane helix | MPSTDLLMLK | MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFVFQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGSPKPH | androgen metabolic process apoptotic signaling pathway ceramide metabolic process estrogen metabolic process face morphogenesis fatty acid metabolic process fibroblast migration hemopoiesis kidney development Leydig cell differentiation luteinization platelet-derived growth factor receptor signaling pathway post-embryonic development regulation of multicellular organism growth roof of mouth development skeletal system morphogenesis spermatogenesis sphingolipid catabolic process sphingolipid metabolic process vasculogenesis endoplasmic reticulum; endoplasmic reticulum membrane pyridoxal phosphate binding sphinganine-1-phosphate aldolase activity Homo sapiens 3D-structure Acetylation Apoptosis Disease variant Endoplasmic reticulum Lipid metabolism Lyase Membrane Nitration Phosphoprotein Pyridoxal phosphate Reference proteome Signal-anchor Sphingolipid metabolism Transmembrane Transmembrane helix MPSTDLLMLK MPSTDLLMLKAFEPYLEILEVYSTKAKNYVNGHCTKYEPWQLIAWSVVWTLLIVWGYEFVFQPESLWSRFKKKCFKLTRKMPIIGRKIQDKLNKTKDDISKNMSFLKVDKEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWSNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGIKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQFPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISADTHKYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKGWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQTTVDRNMVAELSSVFLDSLYSTDTVTQGSQMNGSPKPH |
bicellular tight junction assembly calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell adhesion negative regulation of apoptotic process negative regulation of cell adhesion negative regulation of protein-containing complex assembly positive regulation of cell motility positive regulation of cell population proliferation response to ethanol | apicolateral plasma membrane; basolateral plasma membrane; bicellular tight junction; lateral plasma membrane; plasma membrane | cell adhesion molecule binding identical protein binding protein domain specific binding structural molecule activity | Homo sapiens | Alternative splicing Cell junction Cell membrane Membrane Phosphoprotein Reference proteome Tight junction Transmembrane Transmembrane helix | MANSGLQLLG | MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTGMMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAMGGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGALLSCSCPGNESKAGYRVPRSYPKSNSSKEYV | bicellular tight junction assembly calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell adhesion negative regulation of apoptotic process negative regulation of cell adhesion negative regulation of protein-containing complex assembly positive regulation of cell motility positive regulation of cell population proliferation response to ethanol apicolateral plasma membrane; basolateral plasma membrane; bicellular tight junction; lateral plasma membrane; plasma membrane cell adhesion molecule binding identical protein binding protein domain specific binding structural molecule activity Homo sapiens Alternative splicing Cell junction Cell membrane Membrane Phosphoprotein Reference proteome Tight junction Transmembrane Transmembrane helix MANSGLQLLG MANSGLQLLGFSMALLGWVGLVACTAIPQWQMSSYAGDNIITAQAMYKGLWMDCVTQSTGMMSCKMYDSVLALSAALQATRALMVVSLVLGFLAMFVATMGMKCTRCGGDDKVKKARIAMGGGIIFIVAGLAALVACSWYGHQIVTDFYNPLIPTNIKYEFGPAIFIGWAGSALVILGGALLSCSCPGNESKAGYRVPRSYPKSNSSKEYV |
animal organ morphogenesis eye development regulation of transcription by RNA polymerase II visual perception | chromatin; nucleus; transcription regulator complex | DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding | Homo sapiens | Cataract Developmental protein Disease variant DNA-binding Homeobox Microphthalmia Nucleus Phosphoprotein Reference proteome | MFQLPILNFS | MFQLPILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIVAFHGGNYRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQVLSQGSGRALRAEGDGTPEVLGVATSPAASLSSKAATSAISITSSDSECDI | animal organ morphogenesis eye development regulation of transcription by RNA polymerase II visual perception chromatin; nucleus; transcription regulator complex DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding Homo sapiens Cataract Developmental protein Disease variant DNA-binding Homeobox Microphthalmia Nucleus Phosphoprotein Reference proteome MFQLPILNFS MFQLPILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIVAFHGGNYRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQVLSQGSGRALRAEGDGTPEVLGVATSPAASLSSKAATSAISITSSDSECDI |
canonical Wnt signaling pathway gamete generation mesoderm development mitotic nuclear membrane disassembly nuclear envelope organization positive regulation of canonical Wnt signaling pathway positive regulation of triglyceride biosynthetic process protein dephosphorylation protein localization to nucleus | cytoplasm; endoplasmic reticulum membrane; lipid droplet; Nem1-Spo7 phosphatase complex; nuclear envelope; nuclear membrane | myosin phosphatase activity protein serine/threonine phosphatase activity | Homo sapiens | Endoplasmic reticulum Hydrolase Membrane Nucleus Protein phosphatase Reference proteome Transmembrane Transmembrane helix | MMRTQCLLGL | MMRTQCLLGLRTFVAFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSRNRLAQVKRKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQHRLW | canonical Wnt signaling pathway gamete generation mesoderm development mitotic nuclear membrane disassembly nuclear envelope organization positive regulation of canonical Wnt signaling pathway positive regulation of triglyceride biosynthetic process protein dephosphorylation protein localization to nucleus cytoplasm; endoplasmic reticulum membrane; lipid droplet; Nem1-Spo7 phosphatase complex; nuclear envelope; nuclear membrane myosin phosphatase activity protein serine/threonine phosphatase activity Homo sapiens Endoplasmic reticulum Hydrolase Membrane Nucleus Protein phosphatase Reference proteome Transmembrane Transmembrane helix MMRTQCLLGL MMRTQCLLGLRTFVAFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSRNRLAQVKRKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQHRLW |
glucose metabolic process pentose-phosphate shunt, oxidative branch regulation of cortisol biosynthetic process response to alcohol response to nutrient levels | endoplasmic reticulum; endoplasmic reticulum lumen | 6-phosphogluconolactonase activity carbohydrate binding glucose 1-dehydrogenase (NAD+) activity glucose 1-dehydrogenase (NADP+) activity glucose 1-dehydrogenase activity glucose-6-phosphate dehydrogenase activity NADP binding | Homo sapiens | 3D-structure Alternative splicing Carbohydrate metabolism Disease variant Endoplasmic reticulum Glucose metabolism Glycoprotein Hydrolase Multifunctional enzyme NAD NADP Oxidoreductase Pyrrolidone carboxylic acid Reference proteome Signal | MWNMLIVAMC | MWNMLIVAMCLALLGCLQAQELQGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHSFSFHGAALTAPKQGQELMAKALESLSCPKDMAPSHCAEHKDQFLQLSQYRQLKTAEDYQALNKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPHNVSSAEAVLRHKLQVFQALRGLQRGSAVVGQYQSYSEQVRRELQKPDSFHSLTPTFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNQACCVQSEKHWAAAQSQCLPRQLVFHIGHGDLGSPAVLVSRNLFRPSLPSSWKEMEGPPGLRLFGSPLSDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHKAPRLYPGGAENGRLLDFEFSSGRLFFSQQQPEQLVPGPGPAPMPSDFQVLRAKYRESPLVSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQRLCAEEDQGAQIYAREISALVANSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLVVLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLPHSGQLVWYMDYDAFLG | glucose metabolic process pentose-phosphate shunt, oxidative branch regulation of cortisol biosynthetic process response to alcohol response to nutrient levels endoplasmic reticulum; endoplasmic reticulum lumen 6-phosphogluconolactonase activity carbohydrate binding glucose 1-dehydrogenase (NAD+) activity glucose 1-dehydrogenase (NADP+) activity glucose 1-dehydrogenase activity glucose-6-phosphate dehydrogenase activity NADP binding Homo sapiens 3D-structure Alternative splicing Carbohydrate metabolism Disease variant Endoplasmic reticulum Glucose metabolism Glycoprotein Hydrolase Multifunctional enzyme NAD NADP Oxidoreductase Pyrrolidone carboxylic acid Reference proteome Signal MWNMLIVAMC MWNMLIVAMCLALLGCLQAQELQGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGRGHSFSFHGAALTAPKQGQELMAKALESLSCPKDMAPSHCAEHKDQFLQLSQYRQLKTAEDYQALNKDIEAQLQHAGLREAGRIFYFSVPPFAYEDIARNINSSCRPGPGAWLRVVLEKPFGHDHFSAQQLATELGTFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDGLWNRHHVERVEIIMKETVDAEGRTSFYEEYGVIRDVLQNHLTEVLTLVAMELPHNVSSAEAVLRHKLQVFQALRGLQRGSAVVGQYQSYSEQVRRELQKPDSFHSLTPTFAAVLVHIDNLRWEGVPFILMSGKALDERVGYARILFKNQACCVQSEKHWAAAQSQCLPRQLVFHIGHGDLGSPAVLVSRNLFRPSLPSSWKEMEGPPGLRLFGSPLSDYYAYSPVRERDAHSVLLSHIFHGRKNFFITTENLLASWNFWTPLLESLAHKAPRLYPGGAENGRLLDFEFSSGRLFFSQQQPEQLVPGPGPAPMPSDFQVLRAKYRESPLVSAWSEELISKLANDIEATAVRAVRRFGQFHLALSGGSSPVALFQQLATAHYGFPWAHTHLWLVDERCVPLSDPESNFQGLQAHLLQHVRIPYYNIHPMPVHLQQRLCAEEDQGAQIYAREISALVANSSFDLVLLGMGADGHTASLFPQSPTGLDGEQLVVLTTSPSQPHRRMSLSLPLINRAKKVAVLVMGRMKREITTLVSRVGHEPKKWPISGVLPHSGQLVWYMDYDAFLG |
bicellular tight junction assembly calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell adhesion | bicellular tight junction; cell junction; intracellular membrane-bounded organelle; plasma membrane | identical protein binding structural molecule activity virus receptor activity | Homo sapiens | 3D-structure Cell junction Cell membrane Deafness Host cell receptor for virus entry Host-virus interaction Membrane Non-syndromic deafness Receptor Reference proteome Tight junction Transmembrane Transmembrane helix | MASTGLELLG | MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV | bicellular tight junction assembly calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules cell adhesion bicellular tight junction; cell junction; intracellular membrane-bounded organelle; plasma membrane identical protein binding structural molecule activity virus receptor activity Homo sapiens 3D-structure Cell junction Cell membrane Deafness Host cell receptor for virus entry Host-virus interaction Membrane Non-syndromic deafness Receptor Reference proteome Tight junction Transmembrane Transmembrane helix MASTGLELLG MASTGLELLGMTLAVLGWLGTLVSCALPLWKVTAFIGNSIVVAQVVWEGLWMSCVVQSTGQMQCKVYDSLLALPQDLQAARALCVIALLLALLGLLVAITGAQCTTCVEDEGAKARIVLTAGVILLLAGILVLIPVCWTAHAIIQDFYNPLVAEALKRELGASLYLGWAAAALLMLGGGLLCCTCPPPQVERPRGPRLGYSIPSRSGASGLDKRDYV |
acute inflammatory response cell-cell adhesion chronic inflammatory response coenzyme A catabolic process inflammatory response innate immune response pantothenate metabolic process positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of T cell differentiation in thymus response to oxidative stress | azurophil granule membrane; extracellular region; membrane; plasma membrane; side of membrane | pantetheine hydrolase activity | Homo sapiens | 3D-structure Cell membrane Glycoprotein GPI-anchor Hydrolase Lipoprotein Membrane Reference proteome Signal | MTTQLPAYVA | MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLTAQARIIMLIVIAPIVCSLSW | acute inflammatory response cell-cell adhesion chronic inflammatory response coenzyme A catabolic process inflammatory response innate immune response pantothenate metabolic process positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of T cell differentiation in thymus response to oxidative stress azurophil granule membrane; extracellular region; membrane; plasma membrane; side of membrane pantetheine hydrolase activity Homo sapiens 3D-structure Cell membrane Glycoprotein GPI-anchor Hydrolase Lipoprotein Membrane Reference proteome Signal MTTQLPAYVA MTTQLPAYVAILLFYVSRASCQDTFTAAVYEHAAILPNATLTPVSREEALALMNRNLDILEGAITSAADQGAHIIVTPEDAIYGWNFNRDSLYPYLEDIPDPEVNWIPCNNRNRFGQTPVQERLSCLAKNNSIYVVANIGDKKPCDTSDPQCPPDGRYQYNTDVVFDSQGKLVARYHKQNLFMGENQFNVPKEPEIVTFNTTFGSFGIFTCFDILFHDPAVTLVKDFHVDTIVFPTAWMNVLPHLSAVEFHSAWAMGMRVNFLASNIHYPSKKMTGSGIYAPNSSRAFHYDMKTEEGKLLLSQLDSHPSHSAVVNWTSYASSIEALSSGNKEFKGTVFFDEFTFVKLTGVAGNYTVCQKDLCCHLSYKMSENIPNEVYALGAFDGLHTVEGRYYLQICTLLKCKTTNLNTCGDSAETASTRFEMFSLSGTFGTQYVFPEVLLSENQLAPGEFQVSTDGRLFSLKPTSGPVLTVTLFGRLYEKDWASNASSGLTAQARIIMLIVIAPIVCSLSW |
pantothenate metabolic process | extracellular region; plasma membrane; side of membrane | pantetheine hydrolase activity | Homo sapiens | Alternative splicing Cell membrane Glycoprotein GPI-anchor Hydrolase Lipoprotein Membrane Reference proteome Signal | MVTSSFPISV | MVTSSFPISVAVFALITLQVGTQDSFIAAVYEHAVILPNKTETPVSQEDALNLMNENIDILETAIKQAAEQGARIIVTPEDALYGWKFTRETVFPYLEDIPDPQVNWIPCQDPHRFGHTPVQARLSCLAKDNSIYVLANLGDKKPCNSRDSTCPPNGYFQYNTNVVYNTEGKLVARYHKYHLYSEPQFNVPEKPELVTFNTAFGRFGIFTCFDIFFYDPGVTLVKDFHVDTILFPTAWMNVLPLLTAIEFHSAWAMGMGVNLLVANTHHVSLNMTGSGIYAPNGPKVYHYDMKTELGKLLLSEVDSHPLSSLAYPTAVNWNAYATTIKPFPVQKNTFRGFISRDGFNFTELFENAGNLTVCQKELCCHLSYRMLQKEENEVYVLGAFTGLHGRRRREYWQVCTLLKCKTTNLTTCGRPVETASTRFEMFSLSGTFGTEYVFPEVLLTEIHLSPGKFEVLKDGRLVNKNGSSGPILTVSLFGRWYTKDSLYSSCGTSNSAITYLLIFILLMIIALQNIVML | pantothenate metabolic process extracellular region; plasma membrane; side of membrane pantetheine hydrolase activity Homo sapiens Alternative splicing Cell membrane Glycoprotein GPI-anchor Hydrolase Lipoprotein Membrane Reference proteome Signal MVTSSFPISV MVTSSFPISVAVFALITLQVGTQDSFIAAVYEHAVILPNKTETPVSQEDALNLMNENIDILETAIKQAAEQGARIIVTPEDALYGWKFTRETVFPYLEDIPDPQVNWIPCQDPHRFGHTPVQARLSCLAKDNSIYVLANLGDKKPCNSRDSTCPPNGYFQYNTNVVYNTEGKLVARYHKYHLYSEPQFNVPEKPELVTFNTAFGRFGIFTCFDIFFYDPGVTLVKDFHVDTILFPTAWMNVLPLLTAIEFHSAWAMGMGVNLLVANTHHVSLNMTGSGIYAPNGPKVYHYDMKTELGKLLLSEVDSHPLSSLAYPTAVNWNAYATTIKPFPVQKNTFRGFISRDGFNFTELFENAGNLTVCQKELCCHLSYRMLQKEENEVYVLGAFTGLHGRRRREYWQVCTLLKCKTTNLTTCGRPVETASTRFEMFSLSGTFGTEYVFPEVLLTEIHLSPGKFEVLKDGRLVNKNGSSGPILTVSLFGRWYTKDSLYSSCGTSNSAITYLLIFILLMIIALQNIVML |
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