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PMC7478950 | core_pubmed_pmc | Asian race and origin have no clinically meaningful effects on polatuzumab vedotin pharmacokinetics in patients with relapsed/refractory B-cell non-Hodgkin lymphoma | Asian race and origin have no clinically meaningful effects on polatuzumab vedotin pharmacokinetics in patients with relapsed/refractory B-cell non-Hodgkin lymphoma Abstract Purpose The CD79b-targeted antibody–drug conjugate polatuzumab vedotin (pola), alone and with chemoimmunotherapy, has clinical efficacy and a tole... |
PMC10087980 | core_pubmed_pmc | Population Pharmacokinetics of Oral Brepocitinib in Healthy Volunteers and Patients | Population Pharmacokinetics of Oral Brepocitinib in Healthy Volunteers and Patients Abstract Abstract Brepocitinib is a tyrosine kinase 2 and Janus kinase 1 inhibitor in development for treatment of inflammatory autoimmune diseases. This analysis aimed to add to the pharmacokinetic knowledge of the medication, through ... |
PMC7783832 | core_pubmed_pmc | A survey of therapeutic drug monitoring in a teaching hospital | A survey of therapeutic drug monitoring in a teaching hospital Abstract Abstract Objectives Therapeutic drug monitoring (TDM) is one of the tools that aim to improve and ensure the best therapeutic effects while avoiding drug toxicity. This study aimed to identify the clinical utilization and application of TDM at a ma... |
PMC9880317 | core_pubmed_pmc | Development and validation of two bioanalysis methods for the determination of etimicin in human serum and urine by liquid chromatography-tandem mass spectrometry: Applications to a human pharmacokinetic and breakpoint study | Development and validation of two bioanalysis methods for the determination of etimicin in human serum and urine by liquid chromatography-tandem mass spectrometry: Applications to a human pharmacokinetic and breakpoint study Abstract Etimicin is a fourth-generation aminoglycoside antibiotic. It has potent activity and ... |
PMC9128966 | core_pubmed_pmc | Evaluation of pharmacokinetic interactions of amoxicillin with ranitidine in healthy human volunteers of Karachi, Pakistan | Evaluation of pharmacokinetic interactions of amoxicillin with ranitidine in healthy human volunteers of Karachi, Pakistan Abstract Abstract Polypharmacy may be considered as the customary practice to provide optimum care services to patients but inter resulted in augmented probability of multiple drug interaction. Kee... |
PMC5932779 | core_pubmed_pmc | ATR-101, a selective ACAT1 inhibitor, decreases ACTH-stimulated cortisol concentrations in dogs with naturally occurring Cushing’s syndrome | ATR-101, a selective ACAT1 inhibitor, decreases ACTH-stimulated cortisol concentrations in dogs with naturally occurring Cushing’s syndrome Abstract Background Cushing’s syndrome in humans shares many similarities with its counterpart in dogs in terms of etiology (pituitary versus adrenal causes), clinical signs, and p... |
PMC9174838 | core_pubmed_pmc | Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response | Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response Abstract Purpose Although recombinant human interleukin-15 (rhIL-15) has generated much excitement as an immunotherapeutic agent for cancer... |
PMC9967935 | core_pubmed_pmc | Transferability of Published Population Pharmacokinetic Models for Apixaban and Rivaroxaban to Subjects with Obesity Treated for Venous Thromboembolism: A Systematic Review and External Evaluations | Transferability of Published Population Pharmacokinetic Models for Apixaban and Rivaroxaban to Subjects with Obesity Treated for Venous Thromboembolism: A Systematic Review and External Evaluations Abstract Apixaban and rivaroxaban have first-line use for many patients needing anticoagulation for venous thromboembolism... |
PMC9563815 | core_pubmed_pmc | Overcoming high level adenosine-mediated immunosuppression by DZD2269, a potent and selective A2aR antagonist | Overcoming high level adenosine-mediated immunosuppression by DZD2269, a potent and selective A2aR antagonist Abstract Background Adenosine is a potent immunosuppressant whose levels in the tumor microenvironment (TME) are often much higher than those in normal tissues. Binding of adenosine to its receptor A2aR activat... |
PMC5659256 | core_pubmed_pmc | Developing a novel dual PI3K–mTOR inhibitor from the prodrug of a metabolite | Developing a novel dual PI3K–mTOR inhibitor from the prodrug of a metabolite Abstract This study presents a process of developing a novel PI3K–mTOR inhibitor through the prodrug of a metabolite. The lead compound (compound 1) was identified with similar efficacy as that of NVP-BEZ235 in a tumor xenograft model, but the... |
PMC11579193 | core_pubmed_pmc | pyDarwin machine learning algorithms application and comparison in nonlinear mixed-effect model selection and optimization | pyDarwin machine learning algorithms application and comparison in nonlinear mixed-effect model selection and optimization Abstract Forward addition/backward elimination (FABE) has been the standard for population pharmacokinetic model selection (PPK) since NONMEM® was introduced. We investigated five machine learning ... |
PMC3281083 | core_pubmed_pmc | Impact of the Herbal Medicine Sophora flavescens on the Oral Pharmacokinetics of Indinavir in Rats: The Involvement of CYP3A and P-Glycoprotein | Impact of the Herbal Medicine Sophora flavescens on the Oral Pharmacokinetics of Indinavir in Rats: The Involvement of CYP3A and P-Glycoprotein Abstract Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage, skin diseases, pyretic stranguria and viral hepatitis. In this st... |
PMC12112792 | core_pubmed_pmc | Dihydrogeodin from Fennellia flavipes Modulates Platelet Aggregation via Downregulation of Calcium Signaling, αIIbβ 3 Integrins, MAPK, and PI3K/Akt Pathways | Dihydrogeodin from Fennellia flavipes Modulates Platelet Aggregation via Downregulation of Calcium Signaling, αIIbβ 3 Integrins, MAPK, and PI3K/Akt Pathways Abstract Abstract Cardiovascular disease remains a leading cause of morbidity and mortality worldwide, frequently arising from platelet hyperactivation and subsequ... |
PMC9924091 | core_pubmed_pmc | Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine | Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine Abstract Nirmatrelvir (PF-07321332) is a nitrile-bearing small-molecule inhibitor that, in combination with ritonavir, is used to treat infections by severe acute respiratory sy... |
PMC5651442 | core_pubmed_pmc | Ponezumab in mild-to-moderate Alzheimer's disease: Randomized phase II PET-PIB study | Ponezumab in mild-to-moderate Alzheimer's disease: Randomized phase II PET-PIB study Abstract Abstract Introduction The safety, pharmacokinetics, and effect on peripheral and central amyloid β (Aβ) of multiple doses of ponezumab, an anti-Aβ monoclonal antibody, were characterized in subjects with mild-to-moderate Alzhe... |
PMC7467913 | core_pubmed_pmc | Preclinical Pharmacokinetic/Pharmacodynamic Studies and Clinical Trials in the Drug Development Process of EMA-Approved Antibacterial Agents: A Review | Preclinical Pharmacokinetic/Pharmacodynamic Studies and Clinical Trials in the Drug Development Process of EMA-Approved Antibacterial Agents: A Review Abstract Abstract Development of new antibacterial agents is necessary as drug-resistant bacteria are a threat to global health. In Europe, the European Medicines Agency... |
PMC3485533 | core_pubmed_pmc | Population pharmacokinetics of farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer | Population pharmacokinetics of farletuzumab, a humanized monoclonal antibody against folate receptor alpha, in epithelial ovarian cancer Abstract Abstract Purpose The purpose of this analysis was to develop a population pharmacokinetic model for farletuzumab, a humanized immunoglobulin (Ig)G 1 monoclonal antibody (mAb)... |
PMC8482274 | core_pubmed_pmc | Inadequate Cerebrospinal Fluid Concentrations of Available Salvage Agents Further Impedes the Optimal Treatment of Multidrug-Resistant Enterococcus faecium Meningitis and Bacteremia | Inadequate Cerebrospinal Fluid Concentrations of Available Salvage Agents Further Impedes the Optimal Treatment of Multidrug-Resistant Enterococcus faecium Meningitis and Bacteremia Abstract Background: Vancomycin-resistant Enterococcus faecium (VRE) in particular has evolved as an important cause of hospital acquired ... |
PMC9723225 | core_pubmed_pmc | Effects of intestinal microbiota on pharmacokinetics of cyclosporine a in rats | Effects of intestinal microbiota on pharmacokinetics of cyclosporine a in rats Abstract Abstract Background Intestinal microbiota has been confirmed to influencing the pharmacokinetic processes of a variety of oral drugs. However, the pharmacokinetic effects of the gut microbiota on cyclosporine A, a drug with a narrow... |
PMC7217812 | core_pubmed_pmc | Clinical Pharmacokinetics of Upadacitinib: Review of Data Relevant to the Rheumatoid Arthritis Indication | Clinical Pharmacokinetics of Upadacitinib: Review of Data Relevant to the Rheumatoid Arthritis Indication Abstract Abstract Upadacitinib is a Janus kinase 1 inhibitor developed for treatment of moderate to severe rheumatoid arthritis (RA) and was recently approved by the US Food and Drug Administration for this indicat... |
PMC6853762 | core_pubmed_pmc | Pharmacokinetic and Pharmacodynamic Profiles of Cefiderocol, a Novel Siderophore Cephalosporin | Pharmacokinetic and Pharmacodynamic Profiles of Cefiderocol, a Novel Siderophore Cephalosporin Abstract Abstract Cefiderocol, a novel parenteral siderophore cephalosporin, exhibits potent in vitro activity and in vivo efficacy against most gram-negative bacteria, including carbapenem-resistant strains of Enterobacteria... |
PMC9229563 | core_pubmed_pmc | Pharmacokinetics and the Dermal Absorption of Bromochlorophene, a Cosmetic Preservative Ingredient, in Rats | Pharmacokinetics and the Dermal Absorption of Bromochlorophene, a Cosmetic Preservative Ingredient, in Rats Abstract Abstract The cosmetic industry has flourished in recent years. Accordingly, the safety of cosmetic ingredients is increasing. Bromochlorophene (BCP) is a commonly used cosmetic preservative. To evaluate ... |
PMC9049328 | core_pubmed_pmc | Pre-clinical pharmacokinetic and pharmacodynamic modelling study of 4-hydroxyisoleucine using validated ultra-performance liquid chromatography-tandem mass spectrometry † | Pre-clinical pharmacokinetic and pharmacodynamic modelling study of 4-hydroxyisoleucine using validated ultra-performance liquid chromatography-tandem mass spectrometry † Abstract Abstract A reliable and sensitive ultra-performance liquid chromatography-tandem mass spectrometry-based method has been developed for the e... |
PMC12170649 | core_pubmed_pmc | Therapeutic vancomycin monitoring: a comparative analysis of high-performance liquid chromatography and chemiluminescent microparticle immunoassay methods in liver transplant recipients | Therapeutic vancomycin monitoring: a comparative analysis of high-performance liquid chromatography and chemiluminescent microparticle immunoassay methods in liver transplant recipients Abstract Background Vancomycin is a glycopeptide antibiotic of choice for treating serious Gram-positive bacterial infections, includi... |
PMC8027607 | core_pubmed_pmc | Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects | Acute dose-dependent effects of lysergic acid diethylamide in a double-blind placebo-controlled study in healthy subjects Abstract Abstract Growing interest has been seen in using lysergic acid diethylamide (LSD) in psychiatric research and therapy. However, no modern studies have evaluated subjective and autonomic eff... |
PMC11704096 | core_pubmed_pmc | Identification of novel 3-dehydroquinate dehydratase (DHQD) inhibitors for anti-tuberculosis activity: insights from virtual screening, molecular docking, and dynamics simulations | Identification of novel 3-dehydroquinate dehydratase (DHQD) inhibitors for anti-tuberculosis activity: insights from virtual screening, molecular docking, and dynamics simulations Abstract Tuberculosis (TB) remains a pressing global health concern, causing substantial mortality and morbidity despite existing drugs and ... |
PMC7254632 | core_pubmed_pmc | Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure | Can we optimise doxorubicin treatment regimens for children with cancer? Pharmacokinetic simulations and a Delphi consensus procedure Abstract Abstract Background Despite its cardiotoxicity doxorubicin is widely used for the treatment of paediatric malignancies. Current treatment regimens appear to be suboptimal as tre... |
PMC9381914 | core_pubmed_pmc | Machine learning algorithms to estimate everolimus exposure trained on simulated and patient pharmacokinetic profiles | Machine learning algorithms to estimate everolimus exposure trained on simulated and patient pharmacokinetic profiles Abstract Abstract Everolimus is an immunosuppressant with a small therapeutic index and large between‐patient variability. The area under the concentration versus time curve (AUC) is the best marker of ... |
PMC6850607 | core_pubmed_pmc | Population pharmacokinetics of brodalumab in patients with moderate to severe plaque psoriasis | Population pharmacokinetics of brodalumab in patients with moderate to severe plaque psoriasis Abstract Abstract Brodalumab is a fully human monoclonal antibody targeting the IL‐17 receptor A leading to an inhibition of the biological effect of IL‐17A, IL‐17F, IL‐17A/F heterodimer, IL‐17C and IL‐17E isoforms. It has sh... |
PMC6351525 | core_pubmed_pmc | Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children | Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children Abstract Abstract Young children are the population most severely affected by Plasmodium falciparum malaria. Seasonal malaria chemoprevention (SMC) with amodiaquine and sulfadoxine-pyrimethamine provides substantial ... |
PMC4226839 | core_pubmed_pmc | Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities | Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities Abstract Summary Irinotecan is a water-soluble camptothecin derivative with clinical activity against colorectal and small cell lung cancers and is currently a standa... |
PMC2837469 | core_pubmed_pmc | Quality of Graphite Target for Biological/Biomedical/Environmental Applications of 14 C-Accelerator Mass Spectrometry | Quality of Graphite Target for Biological/Biomedical/Environmental Applications of 14 C-Accelerator Mass Spectrometry Abstract Abstract Catalytic graphitization for 14 C-accelerator mass spectrometry ( 14 C-AMS) produced various forms of elemental carbon. Our high-throughput Zn reduction method (C/Fe = 1:5, 500 °C, 3 h... |
PMC10536516 | core_pubmed_pmc | Improved Pharmacokinetic Feasibilities of Mirabegron-1,2-Ethanedisulfonic Acid, Mirabegron-1,5-Naphthalenedisulfonic Acid, and Mirabegron-L-Pyroglutamic Acid as Co-Amorphous Dispersions in Rats and Mice | Improved Pharmacokinetic Feasibilities of Mirabegron-1,2-Ethanedisulfonic Acid, Mirabegron-1,5-Naphthalenedisulfonic Acid, and Mirabegron-L-Pyroglutamic Acid as Co-Amorphous Dispersions in Rats and Mice Abstract Mirabegron (MBR) is a β 3 -adrenoceptor agonist used for treating overactive bladder syndrome. Due to its po... |
PMC7090185 | core_pubmed_pmc | A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia | A First-in-Human Dose Finding Study of Camrelizumab in Patients with Advanced or Metastatic Cancer in Australia Abstract Purpose Camrelizumab inhibits PD-1 in non-clinical models and showed typical non-clinical pharmacokinetic (PK) and safety profiles for an IgG4 monoclonal antibody. We report results from the First-in... |
PMC7687182 | core_pubmed_pmc | Safety and Pharmacokinetics of High‐Dose TAS‐303 in Healthy Japanese Volunteers: A Single‐Center, Single‐Blind, Randomized, Placebo‐Controlled, Parallel‐Group, Multiple‐Ascending‐Dose Study | Safety and Pharmacokinetics of High‐Dose TAS‐303 in Healthy Japanese Volunteers: A Single‐Center, Single‐Blind, Randomized, Placebo‐Controlled, Parallel‐Group, Multiple‐Ascending‐Dose Study Abstract Abstract Preclinical data of TAS‐303 (4‐piperidinyl 2,2‐diphenyl‐2‐[propoxy‐1,1,2,2,3,3,3‐ d 7 ] acetate hydrochloride), ... |
PMC10787208 | core_pubmed_pmc | Eliciting the antitumor immune response with a conditionally activated PD‐L1 targeting antibody analyzed with a quantitative systems pharmacology model | Eliciting the antitumor immune response with a conditionally activated PD‐L1 targeting antibody analyzed with a quantitative systems pharmacology model Abstract Abstract Conditionally activated molecules, such as Probody therapeutics (PbTx), have recently been investigated to improve antitumoral response while reducing... |
PMC6782035 | core_pubmed_pmc | Pharmacokinetics of prednisolone in children: an open-label, randomised, two-treatment cross-over trial investigating the bioequivalence of different prednisolone formulations in children with airway disease | Pharmacokinetics of prednisolone in children: an open-label, randomised, two-treatment cross-over trial investigating the bioequivalence of different prednisolone formulations in children with airway disease Abstract Introduction One in three Danish children under 3 years of age experience asthma-like symptoms, and one... |
PMC5890768 | core_pubmed_pmc | Modelling of mycobacterial load reveals bedaquiline’s exposure–response relationship in patients with drug-resistant TB | Modelling of mycobacterial load reveals bedaquiline’s exposure–response relationship in patients with drug-resistant TB Abstract Abstract Background Bedaquiline has been shown to reduce time to sputum culture conversion (SCC) and increase cure rates in patients with drug-resistant TB, but the influence of drug exposure... |
PMC7382147 | core_pubmed_pmc | An effective UFLC–MS/MS method used to study pharmacokinetics of major constituents of Fukeqianjin formula in rat plasma | An effective UFLC–MS/MS method used to study pharmacokinetics of major constituents of Fukeqianjin formula in rat plasma Abstract Background Fukeqianjin formula (FKQJF) is a Chinese medicine prescription, which has been widely used individually or in combination with other western medicine for the treatment of various ... |
PMC9946901 | core_pubmed_pmc | The Evaluation of the Efficacy and Safety of Midazolam Nasal Spray in Patients With Seizure Clusters: A Systematic Review and Meta-Analysis | The Evaluation of the Efficacy and Safety of Midazolam Nasal Spray in Patients With Seizure Clusters: A Systematic Review and Meta-Analysis Abstract Abstract Midazolam nasal spray (MDZ-NS) is a new emerging rescue medication that suppresses epileptic seizures. Until now, few studies, pharmacokinetic (PK) and pharmacody... |
PMC7898678 | core_pubmed_pmc | The Burden of the Serious and Difficult-to-Treat Infections and a New Antibiotic Available: Cefiderocol | The Burden of the Serious and Difficult-to-Treat Infections and a New Antibiotic Available: Cefiderocol Abstract Background: Infection is a disease that can occur due to the entrance of a virus, bacteria, and other infectious agents. Cefiderocol is innovative cephalosporin drug that belongs to a special class of antibi... |
PMC10973027 | core_pubmed_pmc | Evaluation and Application of a PET Tracer in Preclinical and Phase 1 Studies to Determine the Brain Biodistribution of Minzasolmin (UCB0599) | Evaluation and Application of a PET Tracer in Preclinical and Phase 1 Studies to Determine the Brain Biodistribution of Minzasolmin (UCB0599) Abstract Abstract Purpose Minzasolmin (UCB0599) is an orally administered, small molecule inhibitor of ASYN misfolding in development as a potential disease-modifying therapy for... |
PMC11215271 | core_pubmed_pmc | Differentiation between primary central nervous system lymphomas and gliomas according to pharmacokinetic parameters derived from dynamic contrast-enhanced magnetic resonance imaging | Differentiation between primary central nervous system lymphomas and gliomas according to pharmacokinetic parameters derived from dynamic contrast-enhanced magnetic resonance imaging Abstract Abstract Purpose It is difficult to differentiate between primary central nervous system lymphoma and primary glioblastoma due t... |
PMC12467171 | core_pubmed_pmc | Development of HPLC-MS/MS Method for Simultaneous Detection of Esketamine and Norketamine: Application to Pharmacokinetics Drug Interactions Affected by Dexmedetomidine | Development of HPLC-MS/MS Method for Simultaneous Detection of Esketamine and Norketamine: Application to Pharmacokinetics Drug Interactions Affected by Dexmedetomidine Abstract Abstract Purpose Dexmedetomidine (DEX) and esketamine (ESK) are often used together during anesthesia. This study aimed to establish a sensiti... |
PMC8424097 | core_pubmed_pmc | Population Pharmacokinetics of Polymyxin B and Dosage Optimization in Renal Transplant Patients | Population Pharmacokinetics of Polymyxin B and Dosage Optimization in Renal Transplant Patients Abstract Abstract Currently, polymyxin B has been widely used in the treatment of multidrug-resistant Gram-negative pathogen infections. Due to the limited pharmacokinetic/pharmacodynamic data, the optimal dosage regimen for... |
PMC7187203 | core_pubmed_pmc | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non–Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non–Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers Abstract Abstract Tropifexor (LJN452) is a potent, orally available, non–bile acid farnesoid X receptor agonist under clinical development for chronic liver diseases. Here, we pr... |
PMC3423889 | core_pubmed_pmc | Adjuvant Bidirectional Chemotherapy with Intraperitoneal Pemetrexed Combined with Intravenous Cisplatin for Diffuse Malignant Peritoneal Mesothelioma | Adjuvant Bidirectional Chemotherapy with Intraperitoneal Pemetrexed Combined with Intravenous Cisplatin for Diffuse Malignant Peritoneal Mesothelioma Abstract Abstract Cytoreductive surgery (CRS) with heated intraoperative intraperitoneal chemotherapy (HIPEC) has emerged as optimal treatment for diffuse malignant perit... |
PMC11124465 | core_pubmed_pmc | A Sensitive Assay for Unbound Docetaxel Using Ultrafiltration plus HPLC-MS and Its Application to a Clinical Study | A Sensitive Assay for Unbound Docetaxel Using Ultrafiltration plus HPLC-MS and Its Application to a Clinical Study Abstract Abstract Introduction: Docetaxel, a taxane used in the treatment of solid tumours, exerts pharmacological activity when in its unbound form. We report a sensitive assay to quantify unbound docetax... |
PMC8961198 | core_pubmed_pmc | TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults) | TRUE-1: Trial of Repurposed Unithiol for snakebite Envenoming phase 1 (safety, tolerability, pharmacokinetics and pharmacodynamics in healthy Kenyan adults) Abstract Background: Snakebites affect over 5 million people each year, and over 100,000 per year die as a result. The only available treatment is antivenom, which... |
PMC11602888 | core_pubmed_pmc | Population pharmacokinetic/target engagement modelling of tozorakimab in healthy volunteers and patients with chronic obstructive pulmonary disease | Population pharmacokinetic/target engagement modelling of tozorakimab in healthy volunteers and patients with chronic obstructive pulmonary disease Abstract Abstract Aims This study describes the pharmacokinetic (PK)/target engagement (TE) relationship of tozorakimab, an anti‐interleukin (IL)‐33 antibody, by building a... |
PMC8513154 | core_pubmed_pmc | Structural principles of insulin formulation and analog design: A century of innovation | Structural principles of insulin formulation and analog design: A century of innovation Abstract Abstract Background The discovery of insulin in 1921 and its near-immediate clinical use initiated a century of innovation. Advances extended across a broad front, from the stabilization of animal insulin formulations to th... |
PMC4605235 | core_pubmed_pmc | Preparation, characterization, in vivo pharmacokinetics, and biodistribution of polymeric micellar dimethoxycurcumin for tumor targeting | Preparation, characterization, in vivo pharmacokinetics, and biodistribution of polymeric micellar dimethoxycurcumin for tumor targeting Abstract Dimethoxycurcumin (DMC) is an analog of curcumin with superior efficacy in various disease models. Currently, drug delivery system research on DMC is very limited, and it has... |
PMC7806714 | core_pubmed_pmc | Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous | Statins for the prevention of proliferative vitreoretinopathy: cellular responses in cultured cells and clinical statin concentrations in the vitreous Abstract Proliferative vitreoretinopathy (PVR) with rhegmatogenous retinal detachment (RRD) is a complex inflammatory ocular disease. Statins are widely used cholesterol... |
PMC6864417 | core_pubmed_pmc | Everolimus Exposure as a Predictor of Toxicity in Renal Cell Cancer Patients in the Adjuvant Setting: Results of a Pharmacokinetic Analysis for SWOG S0931 (EVEREST), a Phase III Study ( NCT01120249 ) | Everolimus Exposure as a Predictor of Toxicity in Renal Cell Cancer Patients in the Adjuvant Setting: Results of a Pharmacokinetic Analysis for SWOG S0931 (EVEREST), a Phase III Study ( NCT01120249 ) Abstract Abstract Background: S0931 is assessing recurrence-free survival in renal cell carcinoma (RCC) patients randomi... |
PMC12776353 | core_pubmed_pmc | Pharmacodynamic individualization of phage therapy against a KPC-5-producing Pseudomonas aeruginosa | Pharmacodynamic individualization of phage therapy against a KPC-5-producing Pseudomonas aeruginosa Abstract Abstract Background There is a resurgence of interest in bacteriophage (phage) therapy as antimicrobials, resulting from growing antimicrobial resistance to small-molecule antibiotics. Phages are bacterial virus... |
PMC12200682 | core_pubmed_pmc | SHR-A1811, a novel anti-HER2 antibody–drug conjugate with optimal drug-to-antibody ratio, efficient tumor killing potency, and favorable safety profiles | SHR-A1811, a novel anti-HER2 antibody–drug conjugate with optimal drug-to-antibody ratio, efficient tumor killing potency, and favorable safety profiles Abstract Abstract HER2-targeting antibody–drug conjugates (ADCs), especially trastuzumab deruxtecan (T-DXd), have revolutionized the treatment landscape of HER2-expres... |
PMC9287224 | core_pubmed_pmc | Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently | Liver Cirrhosis Affects the Pharmacokinetics of the Six Substrates of the Basel Phenotyping Cocktail Differently Abstract Abstract Background Activities of hepatic cytochrome P450 enzymes (CYPs) are relevant for hepatic clearance of drugs and known to be decreased in patients with liver cirrhosis. Several studies have ... |
PMC8467065 | core_pubmed_pmc | Evaluation of the Pharmacokinetics of Intranasal Drug Delivery for Targeting Cervical Lymph Nodes in Rats | Evaluation of the Pharmacokinetics of Intranasal Drug Delivery for Targeting Cervical Lymph Nodes in Rats Abstract A well-developed lymphatic network is located under the nasal mucosa, and a few drugs that permeate the nasal mucosa are absorbed into the lymphatic capillaries. Lymph from the nasal cavity flows to the ce... |
PMC11279552 | core_pubmed_pmc | Unveiling Moroccan Nature’s Arsenal: A Computational Molecular Docking, Density Functional Theory, and Molecular Dynamics Study of Natural Compounds against Drug-Resistant Fungal Infections | Unveiling Moroccan Nature’s Arsenal: A Computational Molecular Docking, Density Functional Theory, and Molecular Dynamics Study of Natural Compounds against Drug-Resistant Fungal Infections Abstract Candida albicans and Aspergillus fumigatus are recognized as significant fungal pathogens, responsible for various human ... |
PMC6223703 | core_pubmed_pmc | A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects | A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects Abstract Abstract Background A formal single ascending and multiple dose pharmacokinetic (PK) trial of ... |
PMC4076805 | core_pubmed_pmc | Evaluation of 4β-Hydroxycholesterol as a Clinical Biomarker of CYP3A4 Drug Interactions Using a Bayesian Mechanism–Based Pharmacometric Model | Evaluation of 4β-Hydroxycholesterol as a Clinical Biomarker of CYP3A4 Drug Interactions Using a Bayesian Mechanism–Based Pharmacometric Model Abstract A Bayesian mechanism–based pharmacokinetic/pharmacodynamic model of cytochrome P450 3A4 (CYP3A4) activity was developed based on a clinical study of the effects of ketoc... |
PMC12300650 | core_pubmed_pmc | Development and Characterization of a New Oral Antileishmanial Bis(pyridine-2-Carboxamidine) Drug Through Innovative Dissolution Testing in Biorelevant Media Combined with Pharmacokinetic Studies | Development and Characterization of a New Oral Antileishmanial Bis(pyridine-2-Carboxamidine) Drug Through Innovative Dissolution Testing in Biorelevant Media Combined with Pharmacokinetic Studies Abstract Abstract Background/Objectives : Currently there are very few effective oral antileishmanial treatments. In this st... |
PMC10342511 | core_pubmed_pmc | Opioid Analgesics after Bariatric Surgery: A Scoping Review to Evaluate Physiological Risk Factors for Opioid-Related Harm | Opioid Analgesics after Bariatric Surgery: A Scoping Review to Evaluate Physiological Risk Factors for Opioid-Related Harm Abstract The persisting use of opioids following bariatric surgery has emerged as a prevalent complication, heightening the probability of opioid-related harm (ORM), such as opioid-related fataliti... |
PMC12857141 | core_pubmed_pmc | Receptor identification and in vivo efficacy of a lytic phage vB_EcoStr-FJ63A against colistin-resistant Escherichia coli | Receptor identification and in vivo efficacy of a lytic phage vB_EcoStr-FJ63A against colistin-resistant Escherichia coli Abstract Abstract Bacteriophages (phages), as natural predators of bacteria, represent promising alternatives to antibiotics. However, challenges such as narrow host range and insufficient pharmacok... |
PMC10674228 | core_pubmed_pmc | Modification of the Physicochemical Properties of Active Pharmaceutical Ingredients via Lyophilization | Modification of the Physicochemical Properties of Active Pharmaceutical Ingredients via Lyophilization Abstract Abstract Bioavailability is an important biopharmaceutical characteristic of active pharmaceutical ingredients (APIs) that is often correlated with their solubility in water. One of the methods of increasing ... |
PMC5625157 | core_pubmed_pmc | Lack of clinically important PK interaction between coformulated ledipasvir/sofosbuvir and rilpivirine/emtricitabine/tenofovir alafenamide | Lack of clinically important PK interaction between coformulated ledipasvir/sofosbuvir and rilpivirine/emtricitabine/tenofovir alafenamide Abstract Abstract The drug–drug interaction (DDI) potential between the fixed‐dose combinations of ledipasvir/sofosbuvir 90/400 mg for hepatitis C virus and emtricitabine/rilpivirin... |
PMC10861834 | core_pubmed_pmc | Pharmacokinetic Comparison Between a Fixed-Dose Combination of Atorvastatin/Omega-3-Acid Ethyl Esters and the Corresponding Loose Combination in Healthy Korean Male Subjects | Pharmacokinetic Comparison Between a Fixed-Dose Combination of Atorvastatin/Omega-3-Acid Ethyl Esters and the Corresponding Loose Combination in Healthy Korean Male Subjects Abstract Abstract Purpose Statins are widely used in combination with omega-3 fatty acids for the treatment of patients with dyslipidemia. The aim... |
PMC8342882 | core_pubmed_pmc | Prediction of Rivaroxaban-Rifampin Interaction After Major Orthopedic Surgery: Physiologically Based Pharmacokinetic Modeling and Simulation | Prediction of Rivaroxaban-Rifampin Interaction After Major Orthopedic Surgery: Physiologically Based Pharmacokinetic Modeling and Simulation Abstract Abstract Rivaroxaban is commonly used for the prophylaxis of venous thromboembolism (VTE) for patients undergoing major orthopedic surgery. Rivaroxaban is primarily elimi... |
PMC6587524 | core_pubmed_pmc | The JAK1 Inhibitor Upadacitinib Has No Effect on the Pharmacokinetics of Levonorgestrel and Ethinylestradiol: A Study in Healthy Female Subjects | The JAK1 Inhibitor Upadacitinib Has No Effect on the Pharmacokinetics of Levonorgestrel and Ethinylestradiol: A Study in Healthy Female Subjects Abstract Abstract Upadacitinib is a novel selective oral Janus kinase 1 (JAK) inhibitor being developed for treatment of several inflammatory diseases. Oral contraceptives are... |
PMC5506666 | core_pubmed_pmc | Formulation and pharmacokinetics of multi-layered matrix tablets: Biphasic delivery of diclofenac | Formulation and pharmacokinetics of multi-layered matrix tablets: Biphasic delivery of diclofenac Abstract The rapid availability of the drug at the site of action followed by maintaining its effect for a long period of time is of great clinical importance. Thus, the purpose of the present study was to prepare and eval... |
PMC8567945 | core_pubmed_pmc | Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics | Saikosaponin D: review on the antitumour effects, toxicity and pharmacokinetics Abstract Abstract Context Bupleuri Radix , the dried root of Bupleurum chinense DC and Bupleurum scorzonerifolium Willd (Apiaceae), is an important medicinal herb widely used to treat cancers for hundreds of years in Asian countries. As the... |
PMC10887906 | core_pubmed_pmc | Exploring the Link between Altitude of Residence and Smoking Patterns in the United States | Exploring the Link between Altitude of Residence and Smoking Patterns in the United States Abstract Abstract Introduction: Smoking-related diseases affect 16 million Americans, causing approximately 480,000 deaths annually. The prevalence of cigarette smoking varies regionally across the United States, and previous res... |
PMC11938900 | core_pubmed_pmc | In silico exploration of bioactive secondary metabolites with anesthetic effects on sodium channels Nav 1.7, 1.8, and 1.9 in painful human dental pulp | In silico exploration of bioactive secondary metabolites with anesthetic effects on sodium channels Nav 1.7, 1.8, and 1.9 in painful human dental pulp Abstract Abstract Aim: To investigate the efficacy of medicinal plant bioactive secondary metabolites as inhibitors of voltage-gated sodium channels (Nav1.7, Nav1.8, and... |
PMC5600110 | core_pubmed_pmc | Pharmacokinetic/pharmacodynamic integration and modelling of oxytetracycline for the porcine pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida | Pharmacokinetic/pharmacodynamic integration and modelling of oxytetracycline for the porcine pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida Abstract Abstract Pharmacokinetic–pharmacodynamic (PK/PD) integration and modelling were used to predict dosage schedules of oxytetracycline for two ... |
PMC4436099 | core_pubmed_pmc | Pharmacokinetics and the optimal regimen for levofloxacin in critically ill patients receiving continuous hemodiafiltration | Pharmacokinetics and the optimal regimen for levofloxacin in critically ill patients receiving continuous hemodiafiltration Abstract Abstract The aim of this study was to establish the pharmacokinetics of levofloxacin (LVFX) and determine the optimal dose of this drug in critically ill patients receiving continuous hem... |
PMC10977013 | core_pubmed_pmc | Human monoclonal antibody F61 nasal spray effectively protected high-risk populations from SARS-CoV-2 variants during the COVID-19 pandemic from late 2022 to early 2023 in China | Human monoclonal antibody F61 nasal spray effectively protected high-risk populations from SARS-CoV-2 variants during the COVID-19 pandemic from late 2022 to early 2023 in China Abstract ABSTRACT Following the national dynamic zero-COVID strategy adjustment, the utilization of broad-spectrum nasal neutralizing antibodi... |
PMC11176165 | core_pubmed_pmc | Combating the causative agent of amoebic keratitis, Acanthamoeba castellanii , using Padina pavonica alcoholic extract: toxicokinetic and molecular docking approaches | Combating the causative agent of amoebic keratitis, Acanthamoeba castellanii , using Padina pavonica alcoholic extract: toxicokinetic and molecular docking approaches Abstract Natural products play a significant role in providing the current demand as antiparasitic agents, which offer an attractive approach for the dis... |
PMC10058213 | core_pubmed_pmc | In Silico Exploration of Metabolically Active Peptides as Potential Therapeutic Agents against Amyotrophic Lateral Sclerosis | In Silico Exploration of Metabolically Active Peptides as Potential Therapeutic Agents against Amyotrophic Lateral Sclerosis Abstract Abstract Amyotrophic lateral sclerosis (ALS) is regarded as a fatal neurodegenerative disease that is featured by progressive damage of the upper and lower motor neurons. To date, over 4... |
PMC10386382 | core_pubmed_pmc | Therapeutic Potential and Predictive Pharmaceutical Modeling of Stilbenes in Cannabis sativa | Therapeutic Potential and Predictive Pharmaceutical Modeling of Stilbenes in Cannabis sativa Abstract Cannabis sativa is a plant used for recreational and therapeutic purposes; however, many of the secondary metabolites in the plant have not been thoroughly investigated. Stilbenes are a class of compounds with demonstr... |
PMC8464829 | core_pubmed_pmc | Review: Influence of the CYP450 Genetic Variation on the Treatment of Psychotic Disorders | Review: Influence of the CYP450 Genetic Variation on the Treatment of Psychotic Disorders Abstract Abstract Second-generation antipsychotic metabolism is mainly carried out by the CYP450 superfamily, which is highly polymorphic. Therefore, knowing the influence of the different known CYP450 polymorphisms on antipsychot... |
PMC11949362 | core_pubmed_pmc | Population pharmacokinetic analysis of intravenous voriconazole in cancer patients | Population pharmacokinetic analysis of intravenous voriconazole in cancer patients Abstract Purpose The pharmacokinetics of voriconazole have been studied across various populations but data specific to the Pakistani cancer population has not yet been reported. The aim of present study was to explore and identify covar... |
PMC3637032 | core_pubmed_pmc | Effect of famotidine on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor | Effect of famotidine on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor Abstract Background Apixaban is an oral, selective, direct factor Xa inhibitor approved for thromboprophylaxis after orthopedic surgery and stroke prevention in patients with atrial fibrillation, and under development for treat... |
PMC12508793 | core_pubmed_pmc | Distribution of CYP2D6 multiplication, CYP2D6*5, and clinical implications in postoperative patients receiving tramadol analgesia in the Minangkabau ethnic group, Indonesia | Distribution of CYP2D6 multiplication, CYP2D6*5, and clinical implications in postoperative patients receiving tramadol analgesia in the Minangkabau ethnic group, Indonesia Abstract Background Cytochrome P450 2D6 (CYP2D6) is an important enzyme that metabolizes commonly used drugs, such as tramadol hydrochloride. Genet... |
PMC4230447 | core_pubmed_pmc | Modeling bioavailability to organs protected by biological barriers | Modeling bioavailability to organs protected by biological barriers Abstract Abstract Computational pharmacokinetic (PK) modeling gives access to drug concentration vs. time profiles in target organs and allows better interpretation of clinical observations of therapeutic or toxic effects. Physiologically-based PK (PBP... |
PMC12515116 | core_pubmed_pmc | Pharmacokinetics of UGN‑102, an investigational mitomycin‑containing reverse thermal gel for the treatment of non-muscle invasive bladder cancer | Pharmacokinetics of UGN‑102, an investigational mitomycin‑containing reverse thermal gel for the treatment of non-muscle invasive bladder cancer Abstract Purpose To evaluate the pharmacokinetic properties of UGN-102, a mitomycin-containing reverse thermal gel. Methods Twelve patients with NMIBC received 6 once-weekly i... |
PMC6587371 | core_pubmed_pmc | Intravenous vortioxetine to accelerate onset of effect in major depressive disorder: a 2-week, randomized, double-blind, placebo-controlled study | Intravenous vortioxetine to accelerate onset of effect in major depressive disorder: a 2-week, randomized, double-blind, placebo-controlled study Abstract This 2-week randomized, double-blind, placebo-controlled fixed-dose study (NCT02919501) explored the potential of accelerating onset of antidepressant efficacy and p... |
PMC3509570 | core_pubmed_pmc | Bioavailability and Brain-Targeting of Geniposide in Gardenia-Borneol Co-Compound by Different Administration Routes in Mice | Bioavailability and Brain-Targeting of Geniposide in Gardenia-Borneol Co-Compound by Different Administration Routes in Mice Abstract Both geniposide (Ge) and borneol (Bo) are bioactive substances derived from traditional Chinese medicine. Injections containing co-compound of Gardenia-Borneol are widely used for stroke... |
PMC12388763 | core_pubmed_pmc | Experimental Evidence of Caffeic Acid’s Neuroprotective Activity in Alzheimer’s Disease: In Vitro, In Vivo, and Delivery-Based Insights | Experimental Evidence of Caffeic Acid’s Neuroprotective Activity in Alzheimer’s Disease: In Vitro, In Vivo, and Delivery-Based Insights Abstract Abstract Background and Objectives : Alzheimer’s disease (AD) is a complex neurodegenerative disorder marked by cholinergic deficits, oxidative stress, amyloid-β (Aβ) aggregat... |
PMC7984088 | core_pubmed_pmc | Renal water conservation and the volume kinetics of fluid‐induced diuresis: A retrospective analysis of two cohorts of elderly men | Renal water conservation and the volume kinetics of fluid‐induced diuresis: A retrospective analysis of two cohorts of elderly men Abstract Abstract Renal water conservation after an overnight fast mirrors the habitual intake of liquid. The hypothesis in the present study was that water conservation influences the diur... |
PMC9827893 | core_pubmed_pmc | Semimechanistic Physiologically‐Based Pharmacokinetic/Pharmacodynamic Model Informing Epcoritamab Dose Selection for Patients With B‐Cell Lymphomas | Semimechanistic Physiologically‐Based Pharmacokinetic/Pharmacodynamic Model Informing Epcoritamab Dose Selection for Patients With B‐Cell Lymphomas Abstract Epcoritamab is a CD3xCD20 bispecific antibody (bsAb) that induces T‐cell–mediated cytotoxicity against CD20‐positive B cells. Target engagement and crosslinking of... |
PMC10949877 | core_pubmed_pmc | Invasive fungal infections and oomycoses in cats 2. Antifungal therapy | Invasive fungal infections and oomycoses in cats 2. Antifungal therapy Abstract Clinical relevance: Invasive fungal infections (IFIs) and oomycoses (hereafter termed invasive fungal-like infections [IFLIs]) are characterised by penetration of tissues by fungal elements. The environment is the most common reservoir of i... |
PMC8304499 | core_pubmed_pmc | Polyester Polymeric Nanoparticles as Platforms in the Development of Novel Nanomedicines for Cancer Treatment | Polyester Polymeric Nanoparticles as Platforms in the Development of Novel Nanomedicines for Cancer Treatment Abstract Simple Summary Despite the existence of powerful therapeutic agents, cancer is still an incurable disease in many clinical scenarios. In this regard, nanomedicine and particularly polymeric nanoparticl... |
PMC4036650 | core_pubmed_pmc | Cannabinoid-Induced Hyperemesis: A Conundrum—From Clinical Recognition to Basic Science Mechanisms | Cannabinoid-Induced Hyperemesis: A Conundrum—From Clinical Recognition to Basic Science Mechanisms Abstract Abstract Cannabinoids are used clinically on a subacute basis as prophylactic agonist antiemetics for the prevention of nausea and vomiting caused by chemotherapeutics. Cannabinoids prevent vomiting by inhibition... |
PMC5301423 | core_pubmed_pmc | Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks | Pharmacokinetic and pharmacodynamic modeling of sarafloxacin against avian pathogenic Escherichia coli in Muscovy ducks Abstract Background This study focused on utilizing pharmacokinetics/pharmacodynamics (PK/PD) modeling to optimize therapeutic dosage regimens of sarafloxacin against avian pathogenic Escherichia. col... |
PMC11255622 | core_pubmed_pmc | Safety, Tolerability, and Pharmacodynamics of AZD3366 (Optimized Human CD39L3 Apyrase) Alone and in Combination With Ticagrelor and Acetylsalicylic Acid: A Phase 1, Randomized, Placebo‐Controlled Study | Safety, Tolerability, and Pharmacodynamics of AZD3366 (Optimized Human CD39L3 Apyrase) Alone and in Combination With Ticagrelor and Acetylsalicylic Acid: A Phase 1, Randomized, Placebo‐Controlled Study Abstract Abstract Background ADP and ATP are importantly involved in vascular and thrombotic homeostasis, via multiple... |
PMC11128879 | core_pubmed_pmc | Physiologically based pharmacokinetic model for predicting the biodistribution of albumin nanoparticles after induction and recovery from acute lung injury | Physiologically based pharmacokinetic model for predicting the biodistribution of albumin nanoparticles after induction and recovery from acute lung injury Abstract Abstract The application of nanomedicine in the treatment of acute lung injury (ALI) has great potential for the development of new therapeutic strategies.... |
PMC3608883 | core_pubmed_pmc | An Open-Label Investigation of the Pharmacokinetic Profiles of Lisdexamfetamine Dimesylate and Venlafaxine Extended-Release, Administered Alone and in Combination, in Healthy Adults | An Open-Label Investigation of the Pharmacokinetic Profiles of Lisdexamfetamine Dimesylate and Venlafaxine Extended-Release, Administered Alone and in Combination, in Healthy Adults Abstract Background Lisdexamfetamine dimesylate (LDX), a prodrug consisting of d -amphetamine and l -lysine, is being studied in clinical ... |
PMC6677645 | core_pubmed_pmc | Questionable Industry-Sponsored Postneonatal Pediatric Studies in Slovenia | Questionable Industry-Sponsored Postneonatal Pediatric Studies in Slovenia Abstract Background US and EU pediatric laws promote industry-sponsored pediatric studies, based on the therapeutic orphans concept that claims discrimination of children in drug treatment and drug development. Objective We investigated the medi... |
PMC5083757 | core_pubmed_pmc | Effect of veliparib (ABT-888) on cardiac repolarization in patients with advanced solid tumors: a randomized, placebo-controlled crossover study | Effect of veliparib (ABT-888) on cardiac repolarization in patients with advanced solid tumors: a randomized, placebo-controlled crossover study Abstract Abstract Purpose Veliparib (ABT-888) is an orally bioavailable potent inhibitor of poly(ADP-ribose) polymerase (PARP)-1 and PARP-2. This phase 1 study evaluated the e... |
PMC9010192 | core_pubmed_pmc | Determination of Senegenin and Tenuifolin in Mouse Blood by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry and Their Pharmacokinetics | Determination of Senegenin and Tenuifolin in Mouse Blood by Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry and Their Pharmacokinetics Abstract Abstract An ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the determination of senegenin and tenuifolin in... |
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