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PMC4195667 | core_pubmed_pmc | Personalized Tacrolimus Dose Requirement by CYP3A5 but Not ABCB1 or ACE Genotyping in Both Recipient and Donor after Pediatric Liver Transplantation | Personalized Tacrolimus Dose Requirement by CYP3A5 but Not ABCB1 or ACE Genotyping in Both Recipient and Donor after Pediatric Liver Transplantation Abstract Tacrolimus (TAC) is the backbone of an immunosuppressive drug used in most solid organ transplant recipients. A single nucleotide polymorphism (SNP) at position 6... |
PMC4259998 | core_pubmed_pmc | Population Pharmacokinetics of Intravenous Artesunate: A Pooled Analysis of Individual Data From Patients With Severe Malaria | Population Pharmacokinetics of Intravenous Artesunate: A Pooled Analysis of Individual Data From Patients With Severe Malaria Abstract Abstract There are ~660,000 deaths from severe malaria each year. Intravenous artesunate (i.v. ARS) is the first-line treatment in adults and children. To optimize the dosing regimen of... |
PMC12679194 | core_pubmed_pmc | Investigating the pharmaceutical substances and action mechanisms of Changmaxifeng granules against tic disorders | Investigating the pharmaceutical substances and action mechanisms of Changmaxifeng granules against tic disorders Abstract Abstract BACKGROUND Tic disorders (TDs) are a type of neurological and psychiatric disorder characterized by vocal or motor tics in the head, body, or limbs. Clinical studies have shown that Changm... |
PMC11459961 | core_pubmed_pmc | Systemic absorption and safety of topical terbinafine hydrochloride 10% solution (MOB015B): a phase 1 maximal usage trial in patients with moderate-to-severe onychomycosis | Systemic absorption and safety of topical terbinafine hydrochloride 10% solution (MOB015B): a phase 1 maximal usage trial in patients with moderate-to-severe onychomycosis Abstract ABSTRACT Topical antifungals may be considered to treat onychomycosis with minimal risk of systemic side effects. In this study, we assess ... |
PMC11509103 | core_pubmed_pmc | Differential Cytoprotective Effect of Resveratrol and Its Derivatives: Focus on Antioxidant and Autophagy-Inducing Effects | Differential Cytoprotective Effect of Resveratrol and Its Derivatives: Focus on Antioxidant and Autophagy-Inducing Effects Abstract Abstract Numerous beneficial effects of resveratrol were reported; however, its pharmacological profile is contradictious. Previously, we have demonstrated that resveratrol has a dose-depe... |
PMC8211846 | core_pubmed_pmc | Identification of optimal dosing schedules of dacomitinib and osimertinib for a phase I/II trial in advanced EGFR -mutant non-small cell lung cancer | Identification of optimal dosing schedules of dacomitinib and osimertinib for a phase I/II trial in advanced EGFR -mutant non-small cell lung cancer Abstract Despite the clinical success of the third-generation EGFR inhibitor osimertinib as a first-line treatment of EGFR -mutant non-small cell lung cancer (NSCLC), resi... |
PMC7588963 | core_pubmed_pmc | 1,1-Difluoroethane Detection Time in Blood after Inhalation Abuse Estimated by Monte Carlo PBPK Modeling | 1,1-Difluoroethane Detection Time in Blood after Inhalation Abuse Estimated by Monte Carlo PBPK Modeling Abstract (1) Background: Inhalant abuse and misuse are still widespread problems. 1,1-Difluoroethane abuse is reported to be potentially fatal and to cause acute and chronic adverse health effects. Lab testing for d... |
PMC5357639 | core_pubmed_pmc | In vivo Efficacy and Pharmacokinetics of Optimized Apidaecin Analogs | In vivo Efficacy and Pharmacokinetics of Optimized Apidaecin Analogs Abstract Proline-rich antimicrobial peptides (PrAMPs) represent promising alternative therapeutic options for the treatment of multidrug-resistant bacterial infections. PrAMPs are predominantly active against Gram-negative bacteria by inhibiting prote... |
PMC6618770 | core_pubmed_pmc | Pharmacokinetics and Target Attainment of Ceftobiprole in Asian and Non‐Asian Subjects | Pharmacokinetics and Target Attainment of Ceftobiprole in Asian and Non‐Asian Subjects Abstract Abstract Ceftobiprole is a broad‐spectrum cephalosporin. The objective of this study was to test the hypothesis that the pharmacokinetics (PK) and exposure of ceftobiprole in Asian subjects are similar to those in non‐Asian ... |
PMC8930902 | core_pubmed_pmc | Randomized Pharmacokinetic Study of a Highly Purified Human Chorionic Gonadotropin and of a Recombinant Human Chorionic Gonadotropin Following Single Subcutaneous Administration in Healthy Women | Randomized Pharmacokinetic Study of a Highly Purified Human Chorionic Gonadotropin and of a Recombinant Human Chorionic Gonadotropin Following Single Subcutaneous Administration in Healthy Women Abstract Abstract Background and Objectives Exogenous human chorionic gonadotropin (hCG) acts on the final phase of the folli... |
PMC7493358 | core_pubmed_pmc | Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT) | Failure of target attainment of beta-lactam antibiotics in critically ill patients and associated risk factors: a two-center prospective study (EXPAT) Abstract Background Early and appropriate antibiotic dosing is associated with improved clinical outcomes in critically ill patients, yet target attainment remains a cha... |
PMC8520751 | core_pubmed_pmc | Pharmacometrics meets statistics—A synergy for modern drug development | Pharmacometrics meets statistics—A synergy for modern drug development Abstract Abstract Modern drug development problems are very complex and require integration of various scientific fields. Traditionally, statistical methods have been the primary tool for design and analysis of clinical trials. Increasingly, pharmac... |
PMC3152769 | core_pubmed_pmc | Pentoxifylline as an adjunct therapy in children with cerebral malaria | Pentoxifylline as an adjunct therapy in children with cerebral malaria Abstract Background Pentoxifylline (PTX) affects many processes that may contribute to the pathogenesis of severe malaria and it has been shown to reduce the duration of coma in children with cerebral malaria. This pilot study was performed to asses... |
PMC6192596 | core_pubmed_pmc | Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies | Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies Abstract New therapeutic biological entities such as bispecific antibodies targeting tissue or specific cell populations form an increasingly important part of the drug development portfolio. However,... |
PMC8632367 | core_pubmed_pmc | Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer | Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer Abstract Background: Data from previous work suggests that there is no correlation between systemic (plasma) paclitaxel exposure and efficacy in patients treated for esophageal cancer. In this trial, we... |
PMC3995995 | core_pubmed_pmc | Development of an Adverse Drug Reaction Risk Assessment Score among Hospitalized Patients with Chronic Kidney Disease | Development of an Adverse Drug Reaction Risk Assessment Score among Hospitalized Patients with Chronic Kidney Disease Abstract Background Adverse drug reactions (ADRs) represent a major burden on the healthcare system. Chronic kidney disease (CKD) patients are particularly vulnerable to ADRs because they are usually on... |
PMC9325261 | core_pubmed_pmc | Developing New Treatments for COVID-19 through Dual-Action Antiviral/Anti-Inflammatory Small Molecules and Physiologically Based Pharmacokinetic Modeling | Developing New Treatments for COVID-19 through Dual-Action Antiviral/Anti-Inflammatory Small Molecules and Physiologically Based Pharmacokinetic Modeling Abstract Abstract Broad-spectrum antiviral agents that are effective against many viruses are difficult to develop, as the key molecules, as well as the biochemical p... |
PMC8989052 | core_pubmed_pmc | The novel bronchodilator navafenterol: a phase 2a, multicentre, randomised, double-blind, placebo-controlled crossover trial in COPD | The novel bronchodilator navafenterol: a phase 2a, multicentre, randomised, double-blind, placebo-controlled crossover trial in COPD Abstract Abstract Background Navafenterol (AZD8871) belongs to a new class of bronchodilator, the single-molecule muscarinic antagonist and β-agonist, developed for the treatment of COPD.... |
PMC12064635 | core_pubmed_pmc | Model-Informed Dose Optimization of Pazopanib in Real-World Patients with Cancer | Model-Informed Dose Optimization of Pazopanib in Real-World Patients with Cancer Abstract Abstract Background and Objectives Pazopanib is approved for metastatic renal cell carcinoma (mRCC) and soft tissue sarcoma (STS) in a dose of 800 mg once daily (QD) taken under fasted conditions. In clinical practice, approximate... |
PMC6461749 | core_pubmed_pmc | Phase 1 dose-finding and pharmacokinetic study of eribulin-liposomal formulation in patients with solid tumours | Phase 1 dose-finding and pharmacokinetic study of eribulin-liposomal formulation in patients with solid tumours Abstract Abstract Background This phase 1 study examined the safety, tolerability, pharmacokinetics and preliminary efficacy of eribulin-liposomal formulation (eribulin-LF) in patients with advanced solid tum... |
PMC7047841 | core_pubmed_pmc | Synthesis, Characterization, and Pharmacodynamics Study of Enrofloxacin Mesylate | Synthesis, Characterization, and Pharmacodynamics Study of Enrofloxacin Mesylate Abstract Introduction Enrofloxacin is used in the treatment of a wide variety of bacterial infections in mammals. However, its poor solubility limits the clinical use. Methods In order to improve the solubility of enrofloxacin, the enroflo... |
PMC12854914 | core_pubmed_pmc | Early Evidence of Safety, Clinical Benefit, and Pharmacokinetics of Roflumilast Cream 0.3% Once Daily for Treatment of Mild or Moderate Plaque Psoriasis in Children Aged 2–11 Years | Early Evidence of Safety, Clinical Benefit, and Pharmacokinetics of Roflumilast Cream 0.3% Once Daily for Treatment of Mild or Moderate Plaque Psoriasis in Children Aged 2–11 Years Abstract ABSTRACT Two 4‐week, phase 2, open‐label, maximal usage pharmacokinetic (PK) and safety studies of once‐daily roflumilast cream 0.... |
PMC7564037 | core_pubmed_pmc | Nonclinical safety, tolerance and pharmacodynamics evaluation for meplazumab treating chloroquine-resistant Plasmodium falciparum | Nonclinical safety, tolerance and pharmacodynamics evaluation for meplazumab treating chloroquine-resistant Plasmodium falciparum Abstract Meplazumab is an anti-CD147 humanized IgG2 antibody. The purpose of this study was to characterize the nonclinical safety, tolerance and efficacy evaluation of meplazumab treating c... |
PMC11774110 | core_pubmed_pmc | Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial | Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial Abstract Purpose HA121-28, a novel multi-targeting tyrosine kinase inhibitor, has dual efficacy against tumor growth and neovascularization. The... |
PMC4961081 | core_pubmed_pmc | Multiscale Systems‐Pharmacology Pipeline to Assess the Prophylactic Efficacy of NRTIs Against HIV‐1 | Multiscale Systems‐Pharmacology Pipeline to Assess the Prophylactic Efficacy of NRTIs Against HIV‐1 Abstract While HIV‐1 continues to spread, the use of antivirals in preexposure prophylaxis (PrEP) has recently been suggested. Here we present a modular systems pharmacology modeling pipeline, predicting PrEP efficacy of... |
PMC9686508 | core_pubmed_pmc | Continuous Piperacillin-Tazobactam Infusion Improves Clinical Outcomes in Critically Ill Patients with Sepsis: A Retrospective, Single-Centre Study | Continuous Piperacillin-Tazobactam Infusion Improves Clinical Outcomes in Critically Ill Patients with Sepsis: A Retrospective, Single-Centre Study Abstract Continuous infusion of beta-lactam antibiotics has emerged as an alternative for the treatment of sepsis because of the favourable pharmacokinetics of continuous i... |
PMC10898943 | core_pubmed_pmc | A Case Report of a Patient with Soaring Clozapine Levels after Developing a Urinary Tract Infection | A Case Report of a Patient with Soaring Clozapine Levels after Developing a Urinary Tract Infection Abstract Abstract Clozapine is an antipsychotic medicine used to treat mental illnesses that is resistant to therapy. It can induce dose-dependent adverse effects such as increased susceptibility to infections and hemato... |
PMC6964137 | core_pubmed_pmc | Phase Ib Study of Combination Therapy with MEK Inhibitor Binimetinib and Phosphatidylinositol 3‐Kinase Inhibitor Buparlisib in Patients with Advanced Solid Tumors with RAS/RAF Alterations | Phase Ib Study of Combination Therapy with MEK Inhibitor Binimetinib and Phosphatidylinositol 3‐Kinase Inhibitor Buparlisib in Patients with Advanced Solid Tumors with RAS/RAF Alterations Abstract Abstract Background This multicenter, open‐label, phase Ib study investigated the safety and efficacy of binimetinib (MEK i... |
PMC8300326 | core_pubmed_pmc | The interaction of alpha-mangostin and its derivatives against main protease enzyme in COVID-19 using in silico methods | The interaction of alpha-mangostin and its derivatives against main protease enzyme in COVID-19 using in silico methods Abstract Abstract More than 111 million people worldwide have been affected by the COVID-19 outbreak caused by SARS-CoV-2. The main therapeutic target of COVID-19 is main protease (Mpro). It plays a k... |
PMC11901792 | core_pubmed_pmc | Chemical Composition and Larvicidal Activity Against Aedes aegypti of the Leaf Essential Oils from Croton blanchetianus | Chemical Composition and Larvicidal Activity Against Aedes aegypti of the Leaf Essential Oils from Croton blanchetianus Abstract The Aedes aegypti mosquito is the primary vector of dengue, a neglected disease and a serious public health problem in tropical countries. The control of this vector has been carried out usin... |
PMC10226671 | core_pubmed_pmc | RLS-0071 Moderated Elevated Myeloperoxidase Level and Activity in an Asymptomatic Subject in Clinical Trial RLS-0071-101 | RLS-0071 Moderated Elevated Myeloperoxidase Level and Activity in an Asymptomatic Subject in Clinical Trial RLS-0071-101 Abstract Patient: Female, 21-year-old Final Diagnosis: Healthy Symptoms: Asymptomatic Clinical Procedure: Clinical trial Specialty: Immunology Objective: Unknown etiology Background: RLS-0071 is a du... |
PMC10389201 | core_pubmed_pmc | A model-based quantitative analysis of efficacy and associated factors of platelet rich plasma treatment for osteoarthritis | A model-based quantitative analysis of efficacy and associated factors of platelet rich plasma treatment for osteoarthritis Abstract Objective: While platelet rich plasma (PRP) has been extensively studied in treating osteoarthritis (OA), there has been an ongoing debate regarding the efficacy of PRP and the optimal su... |
PMC12110728 | core_pubmed_pmc | Pharmacokinetic and Exposure–Response Modeling Support Body Surface Area‐Based Dosing of Farletuzumab Ecteribulin in Japanese Patients with Solid Tumors | Pharmacokinetic and Exposure–Response Modeling Support Body Surface Area‐Based Dosing of Farletuzumab Ecteribulin in Japanese Patients with Solid Tumors Abstract Abstract The first‐in‐human, Phase 1 Study 101 showed antitumor activity and a tolerable safety profile of farletuzumab ecteribulin in Japanese patients with ... |
PMC4503439 | core_pubmed_pmc | Dose-Independent ADME Properties and Tentative Identification of Metabolites of α-Mangostin from Garcinia mangostana in Mice by Automated Microsampling and UPLC-MS/MS Methods | Dose-Independent ADME Properties and Tentative Identification of Metabolites of α-Mangostin from Garcinia mangostana in Mice by Automated Microsampling and UPLC-MS/MS Methods Abstract Abstract The information about a marker compound's pharmacokinetics in herbal products including the characteristics of absorption, dist... |
PMC3590589 | core_pubmed_pmc | Optimized siRNA-PEG Conjugates for Extended Blood Circulation and Reduced Urine Excretion in Mice | Optimized siRNA-PEG Conjugates for Extended Blood Circulation and Reduced Urine Excretion in Mice Abstract Some of the main concerns with in vivo application of naked small interfering RNA are rapid degradation and urinary excretion resulting in a short plasma half-life. In this study we investigated how conjugation of... |
PMC7181426 | core_pubmed_pmc | Pharmacokinetics, Pharmacodynamics, and Safety of Peficitinib (ASP015K) in Healthy Male Caucasian and Japanese Subjects | Pharmacokinetics, Pharmacodynamics, and Safety of Peficitinib (ASP015K) in Healthy Male Caucasian and Japanese Subjects Abstract Background and Objective Peficitinib pharmacokinetics and pharmacodynamics have been characterized mainly in Caucasian subjects. This study investigated the pharmacokinetics, pharmacodynamics... |
PMC10731587 | core_pubmed_pmc | Quantitative systems pharmacology model of erythropoiesis to simulate therapies targeting anemia due to chronic kidney disease | Quantitative systems pharmacology model of erythropoiesis to simulate therapies targeting anemia due to chronic kidney disease Abstract Anemia induced by chronic kidney disease (CKD) has multiple underlying mechanistic causes and generally worsens as CKD progresses. Erythropoietin (EPO) is a key endogenous protein whic... |
PMC5397563 | core_pubmed_pmc | Morphine Pharmacodynamics in Mechanically Ventilated Preterm Neonates Undergoing Endotracheal Suctioning | Morphine Pharmacodynamics in Mechanically Ventilated Preterm Neonates Undergoing Endotracheal Suctioning Abstract To date, morphine pharmacokinetics (PKs) are well quantified in neonates, but results about its efficacy are ambiguous. This work presents an analysis of a previously published study on pain measurements in... |
PMC9263204 | core_pubmed_pmc | Strategies to Reduce Mortality Among Children Living With HIV and Children Exposed to HIV but Are Uninfected, Admitted With Severe Acute Malnutrition at Mulago Hospital, Uganda (REDMOTHIV): A Mixed Methods Study | Strategies to Reduce Mortality Among Children Living With HIV and Children Exposed to HIV but Are Uninfected, Admitted With Severe Acute Malnutrition at Mulago Hospital, Uganda (REDMOTHIV): A Mixed Methods Study Abstract Background Children living with HIV (CLHIV) and children who are exposed to HIV but uninfected (CHE... |
PMC12166440 | core_pubmed_pmc | The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little | The effect of black tea and water temperature on the disintegration of gelatine and HPMC capsules, tested with the paddle device, GastroDuo and in vivo pharmacokinetics: Much ado about little Abstract Fluid co-administered with oral medication directly affects its behaviour. Often, people use fluids other than water wh... |
PMC4598208 | core_pubmed_pmc | Maraviroc: a review of its use in HIV infection and beyond | Maraviroc: a review of its use in HIV infection and beyond Abstract The human immunodeficiency virus-1 (HIV-1) enters target cells by binding its envelope glycoprotein gp120 to the CD4 receptor and/or coreceptors such as C-C chemokine receptor type 5 (CCR5; R5) and C-X-C chemokine receptor type 4 (CXCR4; X4), and R5-tr... |
PMC5020340 | core_pubmed_pmc | Predicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling | Predicting lung dosimetry of inhaled particleborne benzo[a]pyrene using physiologically based pharmacokinetic modeling Abstract Abstract Benzo[a]pyrene (BaP) is a by-product of incomplete combustion of fossil fuels and plant/wood products, including tobacco. A physiologically based pharmacokinetic (PBPK) model for BaP ... |
PMC6118139 | core_pubmed_pmc | Therapeutic implications of nano-encapsulated rifabutin, azithromycin & ethambutol against experimental Mycobacterium avium infection in mice | Therapeutic implications of nano-encapsulated rifabutin, azithromycin & ethambutol against experimental Mycobacterium avium infection in mice Abstract Background & objectives: Mycobacterium avium causes atypical infection in both immunocompetent and immunocompromised individuals. Conventional chemotherapy for M. avium ... |
PMC10448909 | core_pubmed_pmc | A First-in-human, Dose-escalation Study of the Methionine Aminopeptidase 2 Inhibitor M8891 in Patients with Advanced Solid Tumors | A First-in-human, Dose-escalation Study of the Methionine Aminopeptidase 2 Inhibitor M8891 in Patients with Advanced Solid Tumors Abstract Abstract Methionine aminopeptidase 2 (MetAP2) is essential to endothelial cell growth and proliferation during tumor angiogenesis. M8891 is a novel orally bioavailable, potent, sele... |
PMC9331863 | core_pubmed_pmc | Population Pharmacokinetic and Pharmacodynamic Analysis of Dalbavancin for Long-Term Treatment of Subacute and/or Chronic Infectious Diseases: The Major Role of Therapeutic Drug Monitoring | Population Pharmacokinetic and Pharmacodynamic Analysis of Dalbavancin for Long-Term Treatment of Subacute and/or Chronic Infectious Diseases: The Major Role of Therapeutic Drug Monitoring Abstract Abstract A population pharmacokinetic analysis of dalbavancin was conducted in patients with different infection sites. No... |
PMC11966180 | core_pubmed_pmc | Enhanced Absorption and Safety of MuscleBlaze CreAMP™: A Comparative Analysis With Regular Micronized Creatine Monohydrate in Healthy Male Adults | Enhanced Absorption and Safety of MuscleBlaze CreAMP™: A Comparative Analysis With Regular Micronized Creatine Monohydrate in Healthy Male Adults Abstract Background Creatine monohydrate is a widely utilized dietary supplement in sports nutrition, valued for its role in enhancing muscle energy availability, power outpu... |
PMC6955413 | core_pubmed_pmc | Physiologically based pharmacokinetic evaluation of cefuroxime in perioperative antibiotic prophylaxis | Physiologically based pharmacokinetic evaluation of cefuroxime in perioperative antibiotic prophylaxis Abstract Abstract Aims Adequate plasma concentrations of antibiotics during surgery are essential for the prevention of surgical site infections. We examined the pharmacokinetics of 1.5 g cefuroxime administered durin... |
PMC12371256 | core_pubmed_pmc | A Randomized, Open‐Label, Single‐Dose, Parallel‐Group Bioequivalence Study of Ferric Carboxymaltose Injection Under Fasting Conditions in Chinese Adult Subjects With Iron Deficiency Anemia | A Randomized, Open‐Label, Single‐Dose, Parallel‐Group Bioequivalence Study of Ferric Carboxymaltose Injection Under Fasting Conditions in Chinese Adult Subjects With Iron Deficiency Anemia Abstract ABSTRACT The objectives of this study were to compare the pharmacokinetics and safety profiles of the test (T) preparation... |
PMC3957867 | core_pubmed_pmc | Pharmacokinetics of Orally Administered Oseltamivir in Healthy Obese and Nonobese Thai Subjects | Pharmacokinetics of Orally Administered Oseltamivir in Healthy Obese and Nonobese Thai Subjects Abstract Oseltamivir is the most widely used anti-influenza drug. In the 2009 H1N1 pandemic, in which the influenza viruses were oseltamivir sensitive, obesity was identified as a risk factor for severe disease and unfavorab... |
PMC11369432 | core_pubmed_pmc | Study on the uptake of Gastrodin in the liver | Study on the uptake of Gastrodin in the liver Abstract Abstract Background Gastrodin is the active monomer of the Chinese herb Rhizoma Gastrodiae with the largest quantity of active components. Gastrodin is commonly used in the treatment of central nervous system disorders such as headaches and epilepsy due to its seda... |
PMC12038836 | core_pubmed_pmc | Total Synthesis and Pharmacological Evaluation of Phochrodines A–C | Total Synthesis and Pharmacological Evaluation of Phochrodines A–C Abstract The first syntheses of the Phomopsis -isolated natural products phochrodines A–C are reported. Functional group manipulations on a key 5 H -chromeno[4,3- b ]pyridine intermediate, itself synthesized from intramolecular Suzuki–Miyaura coupling, ... |
PMC7136080 | core_pubmed_pmc | Evaluation of pharmacokinetic interactions between amoxicillin, clarithromycin, and the potassium-competitive acid blocker YH4808 in healthy subjects | Evaluation of pharmacokinetic interactions between amoxicillin, clarithromycin, and the potassium-competitive acid blocker YH4808 in healthy subjects Abstract Abstract YH4808 is a novel potassium-competitive acid blocker that was developed as a therapeutic agent for gastric acid-related diseases; it may replace proton ... |
PMC9930093 | core_pubmed_pmc | Supramolecular Phenylalanine-Derived Hydrogels for the Sustained Release of Functional Proteins | Supramolecular Phenylalanine-Derived Hydrogels for the Sustained Release of Functional Proteins Abstract Abstract Protein-based therapeutics have emerged as next-generation pharmaceutical agents for oncology, bone regeneration, autoimmune disorders, viral infections, and other diseases. The clinical application of prot... |
PMC11502236 | core_pubmed_pmc | Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6 , ADRB1 , ADRB2 , ADRA2C , GRK4 , and GRK5 Genotypes and Beta-Blocker Therapy | Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6 , ADRB1 , ADRB2 , ADRA2C , GRK4 , and GRK5 Genotypes and Beta-Blocker Therapy Abstract Beta-blockers are widely used medications for a variety of indications, including heart failure, myocardial infarction, cardiac arrhythmias, and hyperten... |
PMC5572360 | core_pubmed_pmc | Supervised Machine‐Learning Reveals That Old and Obese People Achieve Low Dapsone Concentrations | Supervised Machine‐Learning Reveals That Old and Obese People Achieve Low Dapsone Concentrations Abstract The human species is becoming increasingly obese. Dapsone, which is extensively used across the globe for dermatological disorders, arachnid bites, and for treatment of several bacterial, fungal, and parasitic dise... |
PMC6105874 | core_pubmed_pmc | Pharmacokinetics of rifampicin in adult TB patients and healthy volunteers: a systematic review and meta-analysis | Pharmacokinetics of rifampicin in adult TB patients and healthy volunteers: a systematic review and meta-analysis Abstract Abstract Objectives The objectives of this study were to explore inter-study heterogeneity in the pharmacokinetics (PK) of orally administered rifampicin, to derive summary estimates of rifampicin ... |
PMC12352996 | core_pubmed_pmc | Physiologically-Based Pharmacokinetics and Empirical Pharmacodynamic Modeling for Pediatric Henagliflozin Dosing: Clinical Insights for Chinese Patients | Physiologically-Based Pharmacokinetics and Empirical Pharmacodynamic Modeling for Pediatric Henagliflozin Dosing: Clinical Insights for Chinese Patients Abstract Abstract Objective: This study aimed to present a quantitative modeling and simulation approach for oral henagliflozin, a selective sodium-glucose cotransport... |
PMC9893258 | core_pubmed_pmc | Synthesis, Characterization, Pharmacogenomics, and Molecular Simulation of Pyridinium Type of Ionic Liquids and Their Applications | Synthesis, Characterization, Pharmacogenomics, and Molecular Simulation of Pyridinium Type of Ionic Liquids and Their Applications Abstract Abstract Substituted pyridinium bromides are prepared by conventional and solvent-free greener methods. The solvent-free solid-phase (greener) method is superior to the conventiona... |
PMC12439002 | core_pubmed_pmc | Comparison of Regression and Categorical Analysis for Pharmacokinetic Data From Renal Impairment Studies | Comparison of Regression and Categorical Analysis for Pharmacokinetic Data From Renal Impairment Studies Abstract The US Food and Drug Administration 2024 guidance prefers regression analysis over categorical analysis for pharmacokinetic data for studies that assess pharmacokinetics in patients with impaired renal func... |
PMC5590147 | core_pubmed_pmc | Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer | Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer Abstract Background Studying the intracellular distribution of pharmacological agents, including anticancer compounds, is of central importance in biomedi... |
PMC3516836 | core_pubmed_pmc | Image Guided Biodistribution and Pharmacokinetic Studies of Theranostics | Image Guided Biodistribution and Pharmacokinetic Studies of Theranostics Abstract Abstract Image guided technique is playing an increasingly important role in the investigation of the biodistribution and pharmacokinetics of drugs or drug delivery systems in various diseases, especially cancers. Besides anatomical imagi... |
PMC8894322 | core_pubmed_pmc | Nanomedicine Ex Machina: Between Model-Informed Development and Artificial Intelligence | Nanomedicine Ex Machina: Between Model-Informed Development and Artificial Intelligence Abstract Abstract Today, a growing number of computational aids and simulations are shaping model-informed drug development. Artificial intelligence, a family of self-learning algorithms, is only the latest emerging trend applied by... |
PMC8662762 | core_pubmed_pmc | Rezafungin Versus Caspofungin in a Phase 2, Randomized, Double-blind Study for the Treatment of Candidemia and Invasive Candidiasis: The STRIVE Trial | Rezafungin Versus Caspofungin in a Phase 2, Randomized, Double-blind Study for the Treatment of Candidemia and Invasive Candidiasis: The STRIVE Trial Abstract Abstract Background Rezafungin (RZF) is a novel echinocandin exhibiting distinctive pharmacokinetics/pharmacodynamics. STRIVE was a phase 2, double-blind, random... |
PMC5828556 | core_pubmed_pmc | Steady-State Clozapine and Norclozapine Pharmacokinetics in Maori and European Patients | Steady-State Clozapine and Norclozapine Pharmacokinetics in Maori and European Patients Abstract Abstract Background Clozapine is the most effective drug for treatment-resistant schizophrenia, but its use is limited by toxicity. Because ethnicity has been reported to affect clozapine metabolism, we compared its steady ... |
PMC10786955 | core_pubmed_pmc | Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals | Digoxin Pharmacokinetics in Patients with Obesity Before and After a Gastric Bypass or a Strict Diet Compared with Normal Weight Individuals Abstract Background and Objective Several drugs on the market are substrates for P-glycoprotein (P-gp), an efflux transporter highly expressed in barrier tissues such as the intes... |
PMC6446180 | core_pubmed_pmc | Randomised, double-blind, phase III study comparing the infliximab biosimilar, PF-06438179/GP1111, with reference infliximab: efficacy, safety and immunogenicity from week 30 to week 54 | Randomised, double-blind, phase III study comparing the infliximab biosimilar, PF-06438179/GP1111, with reference infliximab: efficacy, safety and immunogenicity from week 30 to week 54 Abstract Abstract Objective To investigate the efficacy, safety and immunogenicity of PF-06438179/GP1111 (PF-SZ-IFX) compared with Eur... |
PMC10237409 | core_pubmed_pmc | Trotabresib, an oral potent bromodomain and extraterminal inhibitor, in patients with high-grade gliomas: A phase I, “window-of-opportunity” study | Trotabresib, an oral potent bromodomain and extraterminal inhibitor, in patients with high-grade gliomas: A phase I, “window-of-opportunity” study Abstract Abstract Background The bromodomain and extraterminal protein (BET) inhibitor trotabresib has demonstrated antitumor activity in patients with advanced solid tumors... |
PMC6306117 | core_pubmed_pmc | Pharmacokinetic Study of Sirolimus-Eluting BioResorbable Vascular Scaffold System for Treatment of De Novo Native Coronary Lesions: A Sub-Study of MeRes-1 Trial | Pharmacokinetic Study of Sirolimus-Eluting BioResorbable Vascular Scaffold System for Treatment of De Novo Native Coronary Lesions: A Sub-Study of MeRes-1 Trial Abstract Background MeRes100™ (Meril Life Sciences Pvt. Ltd., Vapi, India) is a novel sirolimus-eluting bioresorbable vascular scaffold (BRS). The purpose of t... |
PMC3435480 | core_pubmed_pmc | FUNCTIONAL CHARACTERIZATION OF ABCC2 PROMOTER POLYMORPHISMS AND ALLELE SPECIFIC EXPRESSION | FUNCTIONAL CHARACTERIZATION OF ABCC2 PROMOTER POLYMORPHISMS AND ALLELE SPECIFIC EXPRESSION Abstract Multidrug resistance protein 2 (MRP2, ABCC2) is an efflux membrane transporter highly expressed in liver, kidney and intestine with important physiological and pharmacological roles. The goal of this study was to investi... |
PMC4720030 | core_pubmed_pmc | Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells | Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cells Abstract Metabotropic glutamate receptor 4 (mGluR4) possesses immune modulatory properties in vivo , such that a positive allosteric modulator (PAM) of the receptor confers protection on mi... |
PMC8597115 | core_pubmed_pmc | Base and Covariate Population Pharmacokinetic Analyses of Dupilumab in Adolescents and Children ≥6 to <12 Years of Age Using Phase 3 Data | Base and Covariate Population Pharmacokinetic Analyses of Dupilumab in Adolescents and Children ≥6 to <12 Years of Age Using Phase 3 Data Abstract Abstract Population pharmacokinetic (PK) base and covariate analyses were conducted using data from adolescents with moderate‐to‐severe atopic dermatitis (AD) and children ≥... |
PMC8776711 | core_pubmed_pmc | Impact of Sampling Time Variability on Tacrolimus Dosage Regimen in Pediatric Primary Nephrotic Syndrome: Single-Center, Prospective, Observational Study | Impact of Sampling Time Variability on Tacrolimus Dosage Regimen in Pediatric Primary Nephrotic Syndrome: Single-Center, Prospective, Observational Study Abstract Background: Tacrolimus (TAC) is an important immunosuppressant for children with primary nephrotic syndrome (PNS). The relationship between sampling time var... |
PMC9395610 | core_pubmed_pmc | Spectrum effect correlation of yangyin tongnao granules on cerebral ischemia-reperfusion injury rats | Spectrum effect correlation of yangyin tongnao granules on cerebral ischemia-reperfusion injury rats Abstract Yangyin Tongnao Granules (YYTNG), as traditional Chinese medicine (TCM) compound preparation, have a good curative effect on cerebral ischemia-reperfusion injury. This study aimed to investigate the relationshi... |
PMC10457821 | core_pubmed_pmc | Amorphous Solid Dispersion as Drug Delivery Vehicles in Cancer | Amorphous Solid Dispersion as Drug Delivery Vehicles in Cancer Abstract Cancer treatment has improved over the past decades, but a major challenge lies in drug formulation, specifically for oral administration. Most anticancer drugs have poor water solubility which can affect their bioavailability. This causes suboptim... |
PMC4774801 | core_pubmed_pmc | Pharmacokinetic interaction of curcumin and glibenclamide in diabetic rats | Pharmacokinetic interaction of curcumin and glibenclamide in diabetic rats Abstract Abstract Aim: The aim was to assess the pharmacokinetic (PK) interaction of curcumin and glibenclamide (GL) in diabetic rats. Materials and Methods: Sprague-Dawley rats induced with diabetes were divided into 2 groups of six rats in eac... |
PMC12691640 | core_pubmed_pmc | Unlocking potentials: the impact of meropenem, meropenem-vaborbactam, and ceftazidime-avibactam in combating carbapenem-resistant Enterobacter cloacae | Unlocking potentials: the impact of meropenem, meropenem-vaborbactam, and ceftazidime-avibactam in combating carbapenem-resistant Enterobacter cloacae Abstract ABSTRACT Carbapenem-resistant Enterobacterales (CREs) are recognized as an urgent public threat by the Centers for Disease Control and Prevention. This study as... |
PMC7306027 | core_pubmed_pmc | Single dose epidural hydromorphone in labour pain: maternal pharmacokinetics and neonatal exposure | Single dose epidural hydromorphone in labour pain: maternal pharmacokinetics and neonatal exposure Abstract Abstract Introduction Epidural hydromorphone could be useful in obstetric analgesia as there is a need for a more water-soluble opioid than sufentanil or fentanyl with prolonged analgesic effect. To our knowledge... |
PMC8879496 | core_pubmed_pmc | Anticoronaviral Activity of the Natural Phloroglucinols, Dryocrassin ABBA and Filixic Acid ABA from the Rhizome of Dryopteris crassirhizoma by Targeting the Main Protease of SARS-CoV-2 | Anticoronaviral Activity of the Natural Phloroglucinols, Dryocrassin ABBA and Filixic Acid ABA from the Rhizome of Dryopteris crassirhizoma by Targeting the Main Protease of SARS-CoV-2 Abstract The rhizome of Dryopteris crassirhizoma Nakai. (Dryopteridaceae) has been used in traditional medicine in East Asia and has re... |
PMC12389431 | core_pubmed_pmc | Phytocannabinoids as Novel SGLT2 Modulators for Renal Glucose Reabsorption in Type 2 Diabetes Management | Phytocannabinoids as Novel SGLT2 Modulators for Renal Glucose Reabsorption in Type 2 Diabetes Management Abstract Abstract Background : Sodium–glucose cotransporter 2 (SGLT2) inhibitors have transformed type 2 diabetes mellitus (T2DM) management by promoting glucosuria, lowering glycated hemoglobin (HbA1c), blood press... |
PMC6332382 | core_pubmed_pmc | Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs | Pharmacokinetics of Ginkgolide B after Oral Administration of Three Different Ginkgolide B Formulations in Beagle Dogs Abstract Ginkgolide B (GB), an important active constituent of Ginkgo biloba extract, has been used in clinical applications for the treatment of dementia, cerebral insufficiency or related cognitive d... |
PMC7992283 | core_pubmed_pmc | A novel sustained‐release cysteamine bitartrate formulation for the treatment of cystinosis: Pharmacokinetics and safety in healthy male volunteers | A novel sustained‐release cysteamine bitartrate formulation for the treatment of cystinosis: Pharmacokinetics and safety in healthy male volunteers Abstract Abstract The strict intake regimen of cysteamine bitartrate formulations, associated with side effects, is a concern for the treatment compliance in cystinosis the... |
PMC3970101 | core_pubmed_pmc | A Cell-Based Pharmacokinetics Assay for Evaluating Tubulin-Binding Drugs | A Cell-Based Pharmacokinetics Assay for Evaluating Tubulin-Binding Drugs Abstract Abstract Increasing evidence reveals that traditional pharmacokinetics parameters based on plasma drug concentrations are insufficient to reliably demonstrate accurate pharmacological effects of drugs in target organs or cells in vivo. Th... |
PMC12242391 | core_pubmed_pmc | Evaluation of drug-drug interaction potentials between JP-1366 and celecoxib using physiologically based pharmacokinetic modeling | Evaluation of drug-drug interaction potentials between JP-1366 and celecoxib using physiologically based pharmacokinetic modeling Abstract Abstract Zastaprazan (JP-1366) is a new potassium-competitive acid blocker being developed for treating gastrointestinal reflux disease. It is an orally administered small molecule ... |
PMC12298542 | core_pubmed_pmc | Pharmacokinetics, Safety, and Tolerability of (R)-Ketamine Hydrochloride Injection, a Novel Rapid-Acting Antidepressant, in Healthy Chinese Subjects | Pharmacokinetics, Safety, and Tolerability of (R)-Ketamine Hydrochloride Injection, a Novel Rapid-Acting Antidepressant, in Healthy Chinese Subjects Abstract Abstract Objectives : (R)-ketamine hydrochloride injection is a novel, rapid-acting antidepressant for the treatment of treatment-resistant depression. The aim of... |
PMC6108095 | core_pubmed_pmc | Evaluating the safety, tolerability, pharmacokinetics and efficacy of clofazimine in cryptosporidiosis (CRYPTOFAZ): study protocol for a randomized controlled trial | Evaluating the safety, tolerability, pharmacokinetics and efficacy of clofazimine in cryptosporidiosis (CRYPTOFAZ): study protocol for a randomized controlled trial Abstract Abstract Background Cryptosporidium infection and diarrhea (cryptosporidiosis) is a life-threatening infection in persons with HIV and also in chi... |
PMC5771593 | core_pubmed_pmc | A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study | A non-linear pharmacokinetic-pharmacodynamic relationship of metformin in healthy volunteers: An open-label, parallel group, randomized clinical study Abstract Abstract Background The aim of this study was to explore the pharmacokinetic-pharmacodynamic (PK-PD) relationship of metformin on glucose levels after the admin... |
PMC3825677 | core_pubmed_pmc | Efficacy of Retigabine in Adjunctive Treatment of Partial Onset Seizures in Adults | Efficacy of Retigabine in Adjunctive Treatment of Partial Onset Seizures in Adults Abstract Objective To evaluate efficacy and tolerability of retigabine (ezogabine, US adopted name) in the adjunctive treatment of partial-onset seizures in adults. Retigabine is the first anticonvulsant in its class, decreasing neuronal... |
PMC5382042 | core_pubmed_pmc | Fludarabine with pharmacokinetically-guided IV busulfan is superior to fixed-dose delivery in pretransplant conditioning of AML/MDS patients | Fludarabine with pharmacokinetically-guided IV busulfan is superior to fixed-dose delivery in pretransplant conditioning of AML/MDS patients Abstract We hypothesized that IV Busulfan (Bu) dosing could be safely intensified through pharmacokinetic (PK-) dose guidance to minimize the inter-patient variability in systemic... |
PMC8116427 | core_pubmed_pmc | Pharmacokinetics of Levornidazole Tablet in Healthy Chinese Subjects and Proposed Dosing Regimen Based on Pharmacokinetic/Pharmacodynamic Analysis | Pharmacokinetics of Levornidazole Tablet in Healthy Chinese Subjects and Proposed Dosing Regimen Based on Pharmacokinetic/Pharmacodynamic Analysis Abstract Abstract Introduction Levornidazole is a novel nitroimidazole antimicrobial agent active against anaerobes. We aimed to investigate the pharmacokinetic (PK) profile... |
PMC8658702 | core_pubmed_pmc | Arterial Hypertension in Aortic Valve Stenosis: A Critical Update | Arterial Hypertension in Aortic Valve Stenosis: A Critical Update Abstract Aortic stenosis (AS) is a very common valve disease and is associated with high mortality once it becomes symptomatic. Arterial hypertension (HT) has a high prevalence among patients with AS leading to worse left ventricle remodeling and faster ... |
PMC12844682 | core_pubmed_pmc | Pharmacokinetics and Childhood Obesity: Pathophysiological Basis and Challenges in Choosing the Ideal Body Size Descriptor | Pharmacokinetics and Childhood Obesity: Pathophysiological Basis and Challenges in Choosing the Ideal Body Size Descriptor Abstract Abstract Despite the progressive increase in obesity and associated chronic diseases in children, there is limited evidence on the optimal dosage of most medications for obese children and... |
PMC8245786 | core_pubmed_pmc | Comparative Studies on Multi-Component Pharmacokinetics of Polygonum multiflorum Thunb Extract After Oral Administration in Different Rat Models | Comparative Studies on Multi-Component Pharmacokinetics of Polygonum multiflorum Thunb Extract After Oral Administration in Different Rat Models Abstract Abstract The clinical use of Polygonum multiflorum Thunb (PM) has been restricted or banned in many countries, due to its hepatotoxic adverse effects. Its toxicity re... |
PMC12844686 | core_pubmed_pmc | Efficacy and Safety of SA001 in Patients with Primary Sjögren’s Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial | Efficacy and Safety of SA001 in Patients with Primary Sjögren’s Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial Abstract Abstract Background/Objectives : SA001, a mofetil-ester prodrug of rebamipide, was developed to enhance gastrointestinal absorption and systemic exposure, which was confirmed in a prio... |
PMC11568852 | core_pubmed_pmc | Effect-Site Concentration of Remimazolam by Age Groups During Target-Controlled Infusion for Total Intravenous Anesthesia: A Retrospective Comparative Study | Effect-Site Concentration of Remimazolam by Age Groups During Target-Controlled Infusion for Total Intravenous Anesthesia: A Retrospective Comparative Study Abstract Purpose Pharmacokinetic and pharmacodynamic (PKPD) models exist for remimazolam, but data for target-controlled infusion (TCI) are limited. The Schüttler ... |
PMC6882847 | core_pubmed_pmc | Pharmacogenetics of amfepramone in healthy Mexican subjects reveals potential markers for tailoring pharmacotherapy of obesity: results of a randomised trial | Pharmacogenetics of amfepramone in healthy Mexican subjects reveals potential markers for tailoring pharmacotherapy of obesity: results of a randomised trial Abstract Amfepramone (AFP) is an appetite-suppressant drug used in the treatment of obesity. Nonetheless, studies on interindividual pharmacokinetic variability a... |
PMC11493442 | core_pubmed_pmc | Sensory-Motor Neuropathy in Mfn2 T105M Knock-in Mice and Its Reversal by a Novel Piperine-Derived Mitofusin Activator | Sensory-Motor Neuropathy in Mfn2 T105M Knock-in Mice and Its Reversal by a Novel Piperine-Derived Mitofusin Activator Abstract Mitochondrial dysfunction is a hallmark of many genetic neurodegenerative diseases, but therapeutic options to reverse mitochondrial dysfunction are limited. While recent studies support the po... |
PMC5394133 | core_pubmed_pmc | Pharmacokinetic Properties of Fast-Acting Insulin Aspart Administered in Different Subcutaneous Injection Regions | Pharmacokinetic Properties of Fast-Acting Insulin Aspart Administered in Different Subcutaneous Injection Regions Abstract Abstract Background Fast-acting insulin aspart (faster aspart) is insulin aspart set in a new formulation with faster initial absorption after subcutaneous administration. This study investigated t... |
PMC6360331 | core_pubmed_pmc | Population Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Pediatric Patients with Sickle Cell Disease Treated with Artesunate-Amodiaquine | Population Pharmacokinetic Estimates Suggest Elevated Clearance and Distribution Volume of Desethylamodiaquine in Pediatric Patients with Sickle Cell Disease Treated with Artesunate-Amodiaquine Abstract Abstract Background There is limited information on the safety or efficacy of currently recommended antimalarial drug... |
PMC7962407 | core_pubmed_pmc | A randomized, placebo-controlled experimental medicine study of RIPK1 inhibitor GSK2982772 in patients with moderate to severe rheumatoid arthritis | A randomized, placebo-controlled experimental medicine study of RIPK1 inhibitor GSK2982772 in patients with moderate to severe rheumatoid arthritis Abstract Abstract Background Receptor-interacting protein kinase 1 (RIPK1) is a key mediator of inflammation through cell death and proinflammatory cytokine production. Thi... |
PMC7617887 | core_pubmed_pmc | A novel LC-MS/MS method for the determination of favipiravir ribofuranosyl-5’-triphosphate (T-705-RTP) in human peripheral mononuclear cells | A novel LC-MS/MS method for the determination of favipiravir ribofuranosyl-5’-triphosphate (T-705-RTP) in human peripheral mononuclear cells Abstract Favipiravir is a broad-spectrum antiviral that is metabolised intracellularly into the active form, favipiravir ribofuranosyl-5’-triphosphate (F-RTP). Measurement of the ... |
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