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PMC11975203 | core_pubmed_pmc | Evaluation of the Effect of Momelotinib on Cardiac Repolarization: A Thorough QT Study | Evaluation of the Effect of Momelotinib on Cardiac Repolarization: A Thorough QT Study Abstract Abstract A randomized, partially blinded, placebo‐controlled, crossover study in 48 healthy adults assessed the effect of momelotinib on the heart rate‐corrected QT interval (QTc) using the Fridericia formula (QTcF). QTc was... |
PMC12107230 | core_pubmed_pmc | Therapeutic drug monitoring for antimicrobial agents for people living with HIV (TAP) | Therapeutic drug monitoring for antimicrobial agents for people living with HIV (TAP) Abstract Background Antimicrobial resistance (AMR) is a growing health concern, particularly in Africa, and is predicted to become the leading cause of death after cancer by 2050. Factors like overuse or inappropriate use of antibioti... |
PMC3262391 | core_pubmed_pmc | Two-way pharmacokinetic interaction studies between saxagliptin and cytochrome P450 substrates or inhibitors: simvastatin, diltiazem extended-release, and ketoconazole | Two-way pharmacokinetic interaction studies between saxagliptin and cytochrome P450 substrates or inhibitors: simvastatin, diltiazem extended-release, and ketoconazole Abstract Background Many medicines, including several cholesterol-lowering agents (eg, lovastatin, simvastatin), antihypertensives (eg, diltiazem, nifed... |
PMC11098160 | core_pubmed_pmc | Model‐based meta‐analysis to quantify the effects of short interfering RNA therapeutics on hepatitis B surface antigen turnover in hepatitis B‐infected mice | Model‐based meta‐analysis to quantify the effects of short interfering RNA therapeutics on hepatitis B surface antigen turnover in hepatitis B‐infected mice Abstract Abstract The objective of this study was to compare the efficacy of short interfering RNA therapeutics (siRNAs) in reducing hepatitis B surface antigen (H... |
PMC10583248 | core_pubmed_pmc | Population pharmacokinetics of apixaban in a real‐life hospitalized population from the OptimAT study | Population pharmacokinetics of apixaban in a real‐life hospitalized population from the OptimAT study Abstract Abstract This study aimed to characterize apixaban pharmacokinetics (PKs) and its variability in a real‐world clinical setting of hospitalized patients using a population PK (PopPK) approach. Model‐based simul... |
PMC11659111 | core_pubmed_pmc | Efflux and uptake transport and gut microbial reactivation of raloxifene glucuronides | Efflux and uptake transport and gut microbial reactivation of raloxifene glucuronides Abstract Abstract Raloxifene has low bioavailability due to extensive glucuronidation in the intestine and the liver, and its pharmacokinetics is associated with high intra‐ and interindividual variability. Some of this variability co... |
PMC5061948 | core_pubmed_pmc | Pharmacokinetic, Pharmacogenetic, and Other Factors Influencing CNS Penetration of Antiretrovirals | Pharmacokinetic, Pharmacogenetic, and Other Factors Influencing CNS Penetration of Antiretrovirals Abstract Abstract Neurological complications associated with the human immunodeficiency virus (HIV) are a matter of great concern. While antiretroviral (ARV) drugs are the cornerstone of HIV treatment and typically produc... |
PMC7307240 | core_pubmed_pmc | A multicenter, phase I, pharmacokinetic study of osimertinib in cancer patients with normal renal function or severe renal impairment | A multicenter, phase I, pharmacokinetic study of osimertinib in cancer patients with normal renal function or severe renal impairment Abstract Abstract Osimertinib is a third‐generation, irreversible, oral epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitor (TKI) that potently and selectively inhibits bot... |
PMC11733924 | core_pubmed_pmc | A Dynamic Breathing Lung Chip for Precise Evaluation of Inhaled Drug Efficacy and Airway Epithelial Responses | A Dynamic Breathing Lung Chip for Precise Evaluation of Inhaled Drug Efficacy and Airway Epithelial Responses Abstract Inhaled therapy has become a crucial treatment option for respiratory diseases like asthma, cystic fibrosis, and chronic obstructive pulmonary disease (COPD), delivering drugs directly to bronchial and... |
PMC7891593 | core_pubmed_pmc | Exposure–Response Analyses of Anaplastic Lymphoma Kinase Inhibitors Crizotinib and Alectinib in Non‐Small Cell Lung Cancer Patients | Exposure–Response Analyses of Anaplastic Lymphoma Kinase Inhibitors Crizotinib and Alectinib in Non‐Small Cell Lung Cancer Patients Abstract Abstract Crizotinib and alectinib are anaplastic lymphoma kinase (ALK)‐inhibitors indicated for the treatment of ALK‐positive metastatic non‐small cell lung cancer (NSCLC). At the... |
PMC5026379 | core_pubmed_pmc | A Liver-Centric Multiscale Modeling Framework for Xenobiotics | A Liver-Centric Multiscale Modeling Framework for Xenobiotics Abstract We describe a multi-scale, liver-centric in silico modeling framework for acetaminophen pharmacology and metabolism. We focus on a computational model to characterize whole body uptake and clearance, liver transport and phase I and phase II metaboli... |
PMC10326127 | core_pubmed_pmc | A case report of typhlitis during novel use of ropidoxuridine–capecitabine–radiotherapy for treatment-naïve rectal cancer | A case report of typhlitis during novel use of ropidoxuridine–capecitabine–radiotherapy for treatment-naïve rectal cancer Abstract Background Rectal carcinomas are tumors that arise from the last 12 cm of the large intestine closest to the anus. They generally have a modest prognosis exacerbated by a high local recurre... |
PMC8448008 | core_pubmed_pmc | Obesity in inflammatory bowel disease: A review of its role in the pathogenesis, natural history, and treatment of IBD | Obesity in inflammatory bowel disease: A review of its role in the pathogenesis, natural history, and treatment of IBD Abstract In contrast to previous perceptions that inflammatory bowel disease (IBD) patients are generally malnourished and underweight, there is mounting evidence to suggest that rates of obesity in IB... |
PMC5805504 | core_pubmed_pmc | Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor | Preclinical assessment of galunisertib (LY2157299 monohydrate), a first-in-class transforming growth factor-β receptor type I inhibitor Abstract Transforming growth factor-β (TGFβ) is an important driver of tumor growth via intrinsic and extrinsic mechanisms, and is therefore an attractive target for developing cancer ... |
PMC7379497 | core_pubmed_pmc | Pharmacokinetics of harpagoside in horses after intragastric administration of a Devil's claw (Harpagophytum procumbens) extract | Pharmacokinetics of harpagoside in horses after intragastric administration of a Devil's claw (Harpagophytum procumbens) extract Abstract Abstract Devil's claw is used for the treatment of inflammatory symptoms and degenerative disorders in horses since many years, but without the substantive pharmacokinetic data. The ... |
PMC7143261 | core_pubmed_pmc | Bioavailability of Melatonin from Lentil Sprouts and Its Role in the Plasmatic Antioxidant Status in Rats | Bioavailability of Melatonin from Lentil Sprouts and Its Role in the Plasmatic Antioxidant Status in Rats Abstract Melatonin is a multifunctional antioxidant neurohormone found in plant foods such as lentil sprouts. We aim to evaluate the effect of lentil sprout intake on the plasmatic levels of melatonin and metabolic... |
PMC3418170 | core_pubmed_pmc | Improved biological properties and hypouricemic effects of uricase from Candida utilis loaded in novel alkaline enzymosomes | Improved biological properties and hypouricemic effects of uricase from Candida utilis loaded in novel alkaline enzymosomes Abstract Objective: Previous studies on various enzymosomes (functional lipid vesicles encapsulating an enzyme) have been mostly carried out in vitro and have focused on preserving catalytic activ... |
PMC8744811 | core_pubmed_pmc | Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats | Anticonvulsive Effects and Pharmacokinetic Profile of Cannabidiol (CBD) in the Pentylenetetrazol (PTZ) or N-Methyl-D-Aspartate (NMDA) Models of Seizures in Infantile Rats Abstract In spite of use of cannabidiol (CBD), a non-psychoactive cannabinoid, in pediatric patients with epilepsy, preclinical studies on its effect... |
PMC6567967 | core_pubmed_pmc | Research tools for extrapolating the disposition and pharmacokinetics of nanomaterials from preclinical animals to humans | Research tools for extrapolating the disposition and pharmacokinetics of nanomaterials from preclinical animals to humans Abstract A critical step in the translational science of nanomaterials from preclinical animal studies to humans is the comprehensive investigation of their disposition (or ADME) and pharmacokinetic... |
PMC8587571 | core_pubmed_pmc | Mollusc-Derived Brominated Indoles for the Selective Inhibition of Cyclooxygenase: A Computational Expedition | Mollusc-Derived Brominated Indoles for the Selective Inhibition of Cyclooxygenase: A Computational Expedition Abstract Abstract Inflammation plays an important role in different chronic diseases. Brominated indoles derived from the Australian marine mollusk Dicathais orbita ( D. orbita ) are of interest for their anti-... |
PMC11693714 | core_pubmed_pmc | Comparative immunogenicity assessment of biosimilar natalizumab to its reference medicine: a matching immunogenicity profile | Comparative immunogenicity assessment of biosimilar natalizumab to its reference medicine: a matching immunogenicity profile Abstract Background Biosimilar natalizumab (biosim-NTZ) is the first biosimilar monoclonal antibody of reference natalizumab (ref-NTZ) for treatment of relapsing forms of multiple sclerosis (MS).... |
PMC4148169 | core_pubmed_pmc | 4-Aminopyridyl-Based CYP51 Inhibitors as Anti- Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency | 4-Aminopyridyl-Based CYP51 Inhibitors as Anti- Trypanosoma cruzi Drug Leads with Improved Pharmacokinetic Profile and in Vivo Potency Abstract Abstract CYP51 is a P450 enzyme involved in the biosynthesis of the sterol components of eukaryotic cell membranes. CYP51 inhibitors have been developed to treat infections caus... |
PMC11775036 | core_pubmed_pmc | Effects of zuranolone on next-day simulated driving in healthy adults | Effects of zuranolone on next-day simulated driving in healthy adults Abstract Rationale Zuranolone is an oral positive allosteric modulator of GABA A receptors. Due to its central nervous system (CNS) activity, zuranolone may impact activities requiring complex cognition, including driving. Objective Evaluate the effe... |
PMC3506575 | core_pubmed_pmc | GLP2-2G-XTEN: A Pharmaceutical Protein with Improved Serum Half-Life and Efficacy in a Rat Crohn’s Disease Model | GLP2-2G-XTEN: A Pharmaceutical Protein with Improved Serum Half-Life and Efficacy in a Rat Crohn’s Disease Model Abstract Objectives Glucagon-like peptide 2 (GLP2) is an intestinal growth factor that has been shown to stimulate intestinal growth and reduce disease severity in preclinical models of short bowel syndrome ... |
PMC9334058 | core_pubmed_pmc | In-Depth Study of Thymus vulgaris Essential Oil: Towards Understanding the Antibacterial Target Mechanism and Toxicological and Pharmacological Aspects | In-Depth Study of Thymus vulgaris Essential Oil: Towards Understanding the Antibacterial Target Mechanism and Toxicological and Pharmacological Aspects Abstract Abstract Questions have been raised apropos the emerging problem of microbial resistance, which may pose a great hazard to the human health. Among biosafe comp... |
PMC11136808 | core_pubmed_pmc | A population pharmacokinetics model of balovaptan to support dose selection in adult and pediatric populations | A population pharmacokinetics model of balovaptan to support dose selection in adult and pediatric populations Abstract Balovaptan is a brain-penetrating vasopressin receptor 1a antagonist previously investigated for the core symptoms of autism spectrum disorder (ASD). A population pharmacokinetic (PK) model of balovap... |
PMC12564590 | core_pubmed_pmc | Exploring the Anticancer Potential of Coriolus versicolor in Breast Cancer: A Review | Exploring the Anticancer Potential of Coriolus versicolor in Breast Cancer: A Review Abstract Breast cancer remains a leading cause of morbidity and mortality among women globally, with increasing incidence projected in the coming years. Despite advances in standard oncologic therapies, there is a growing interest in s... |
PMC2890358 | core_pubmed_pmc | Dose-Response Effects of Insulin Glargine in Type 2 Diabetes | Dose-Response Effects of Insulin Glargine in Type 2 Diabetes Abstract Abstract OBJECTIVE To determine the pharmacokinetic and pharmacodynamic dose-response effects of insulin glargine administered subcutaneously in individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS Twenty obese type 2 diabetic individuals (1... |
PMC10199278 | core_pubmed_pmc | Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients | Drug repositioning targeting glutaminase reveals drug candidates for the treatment of Alzheimer’s disease patients Abstract Abstract Background Despite numerous clinical trials and decades of endeavour, there is still no effective cure for Alzheimer's disease. Computational drug repositioning approaches may be employed... |
PMC9428304 | core_pubmed_pmc | Rotational intraperitoneal pressurized aerosol chemotherapy with paclitaxel and cisplatin: pharmacokinetics, tissue concentrations, and toxicities in a pig model | Rotational intraperitoneal pressurized aerosol chemotherapy with paclitaxel and cisplatin: pharmacokinetics, tissue concentrations, and toxicities in a pig model Abstract Objective We used paclitaxel and cisplatin, known to be effective in intraperitoneal chemotherapy, in a novel prototype of rotational intraperitoneal... |
PMC10351292 | core_pubmed_pmc | SuPreme Study: a protocol to study the neuroprotective potential of sulfate among very/extremely preterm infants | SuPreme Study: a protocol to study the neuroprotective potential of sulfate among very/extremely preterm infants Abstract Introduction Antenatal maternal magnesium sulfate (MgSO 4 ) administration is a proven efficacious neuroprotective treatment reducing the risk of cerebral palsy (CP) among infants born preterm. Iden... |
PMC10789662 | core_pubmed_pmc | Advancing Subcutaneous Dosing Regimens for Biotherapeutics: Clinical Strategies for Expedited Market Access | Advancing Subcutaneous Dosing Regimens for Biotherapeutics: Clinical Strategies for Expedited Market Access Abstract Abstract In recent years, subcutaneous administration of biotherapeutics has made significant progress. The self-administration market for rheumatoid arthritis has witnessed the introduction of additiona... |
PMC5383603 | core_pubmed_pmc | Effects of CYP2C19 Genetic Polymorphisms on PK/PD Responses of Omeprazole in Korean Healthy Volunteers | Effects of CYP2C19 Genetic Polymorphisms on PK/PD Responses of Omeprazole in Korean Healthy Volunteers Abstract The aim of this study was to examine the effects of CYP2C19*2 and *3 genetic polymorphisms on omeprazole pharmacokinetic (PK) and pharmacodynamic (PD) responses. Twenty-four healthy Korean volunteers were enr... |
PMC9966787 | core_pubmed_pmc | Integrated Computational Approaches for Inhibiting Sex Hormone-Binding Globulin in Male Infertility by Screening Potent Phytochemicals | Integrated Computational Approaches for Inhibiting Sex Hormone-Binding Globulin in Male Infertility by Screening Potent Phytochemicals Abstract Male infertility is significantly influenced by the plasma-protein sex hormone-binding globulin (SHBG). Male infertility, erectile dysfunction, prostate cancer, and several oth... |
PMC12276709 | core_pubmed_pmc | Modeling of pharmacokinetic/pharmacodynamic parameters in regular intermittent intravenous infusion and translational application of the models in personalized antibiotics dosing | Modeling of pharmacokinetic/pharmacodynamic parameters in regular intermittent intravenous infusion and translational application of the models in personalized antibiotics dosing Abstract Objective Quantitative calculation models for the ratio of daily area under the concentration–time curve (AUC 24 ) to the minimum in... |
PMC8251565 | core_pubmed_pmc | Survival assessment of the extended‐wear insulin infusion set featuring lantern technology in adults with type 1 diabetes by the glucose clamp technique | Survival assessment of the extended‐wear insulin infusion set featuring lantern technology in adults with type 1 diabetes by the glucose clamp technique Abstract Abstract Maintaining good glycaemic control with the same infusion set for longer than 3 days may improve the quality of life of insulin pump users. The aim o... |
PMC7858623 | core_pubmed_pmc | Cyclodextrin-based host-guest complexes loaded with regorafenib for colorectal cancer treatment | Cyclodextrin-based host-guest complexes loaded with regorafenib for colorectal cancer treatment Abstract Abstract The malignancy of colorectal cancer (CRC) is connected with inflammation and tumor-associated macrophages (TAMs), but effective therapeutics for CRC are limited. To integrate therapeutic targeting with tumo... |
PMC6969165 | core_pubmed_pmc | Large-scale Analyses of Disease Biomarkers and Apremilast Pharmacodynamic Effects | Large-scale Analyses of Disease Biomarkers and Apremilast Pharmacodynamic Effects Abstract Abstract Finding biomarkers that provide shared link between disease severity, drug-induced pharmacodynamic effects and response status in human trials can provide number of values for patient benefits: elucidating current therap... |
PMC5762979 | core_pubmed_pmc | Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression | Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression Abstract The hepatocyte-specific asialoglycoprotein receptor (ASGPR) is an ideal candidate for targeted drug delivery to the liver due to its high capacity for substrate clearance from circula... |
PMC11098907 | core_pubmed_pmc | Dose-dependent effect of lamotrigine on quetiapine serum concentration in patients using instant release tablets | Dose-dependent effect of lamotrigine on quetiapine serum concentration in patients using instant release tablets Abstract Abstract Purpose Lamotrigine was previously reported to reduce serum concentration of quetiapine. The aim of this study was to investigate whether lamotrigine dose or quetiapine formulation was of i... |
PMC4147042 | core_pubmed_pmc | Statistical Power Calculations for Mixed Pharmacokinetic Study Designs Using a Population Approach | Statistical Power Calculations for Mixed Pharmacokinetic Study Designs Using a Population Approach Abstract Simultaneous modelling of dense and sparse pharmacokinetic data is possible with a population approach. To determine the number of individuals required to detect the effect of a covariate, simulation-based power ... |
PMC6554016 | core_pubmed_pmc | The daily practice of direct oral anticoagulant use in patients with atrial fibrillation; an observational cohort study | The daily practice of direct oral anticoagulant use in patients with atrial fibrillation; an observational cohort study Abstract Background Direct oral anticoagulants (DOACs) are administered in fixed doses without monitoring. There is still little published data on the impact of the absence of monitoring on adherence ... |
PMC3681568 | core_pubmed_pmc | Why do hypertensive patients of African ancestry respond better to calcium blockers and diuretics than to ACE inhibitors and β-adrenergic blockers? A systematic review | Why do hypertensive patients of African ancestry respond better to calcium blockers and diuretics than to ACE inhibitors and β-adrenergic blockers? A systematic review Abstract Abstract Background Clinicians are encouraged to take an individualized approach when treating hypertension in patients of African ancestry, bu... |
PMC4208492 | core_pubmed_pmc | Optimizing antimicrobial therapy in critically ill patients | Optimizing antimicrobial therapy in critically ill patients Abstract Abstract Critically ill patients with infection in the intensive care unit (ICU) would certainly benefit from timely bacterial identification and effective antimicrobial treatment. Diagnostic techniques have clearly improved in the last years and allo... |
PMC5934856 | core_pubmed_pmc | In vitro antineoplastic effects of auranofin in canine lymphoma cells | In vitro antineoplastic effects of auranofin in canine lymphoma cells Abstract Background The orally available gold complex auranofin (AF) has been used in humans, primarily as an antirheumatic/immunomodulatory agent. It has been safely administered to healthy dogs to establish pharmacokinetic parameters for oral admin... |
PMC4767720 | core_pubmed_pmc | Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies | Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies Abstract Background Fostamatinib (R788) is a spleen tyrosine kinase (SYK) inhibitor. The active metabolite of fostamatinib, R406... |
PMC8857346 | core_pubmed_pmc | Use of a Novel EEG-Based Objective Test, the Cognalyzer ® , in Quantifying the Strength and Determining the Action Time of Cannabis Psychoactive Effects and Factors that May Influence Them Within an Observational Study Framework | Use of a Novel EEG-Based Objective Test, the Cognalyzer ® , in Quantifying the Strength and Determining the Action Time of Cannabis Psychoactive Effects and Factors that May Influence Them Within an Observational Study Framework Abstract Introduction Current methods to detect recent delta-9-tetrahydrocannabinol (THC) u... |
PMC4853014 | core_pubmed_pmc | Development and evaluation of vitamin E d -α-tocopheryl polyethylene glycol 1000 succinate-mixed polymeric phospholipid micelles of berberine as an anticancer nanopharmaceutical | Development and evaluation of vitamin E d -α-tocopheryl polyethylene glycol 1000 succinate-mixed polymeric phospholipid micelles of berberine as an anticancer nanopharmaceutical Abstract Abstract Berberine (Brb) is an active alkaloid occurring in various common plant species, with well-recognized potential for cancer t... |
PMC5111764 | core_pubmed_pmc | Pharmacokinetics and Pharmacodynamics of Omarigliptin, a Once‐Weekly Dipeptidyl Peptidase‐4 (DPP‐4) Inhibitor, After Single and Multiple Doses in Healthy Subjects | Pharmacokinetics and Pharmacodynamics of Omarigliptin, a Once‐Weekly Dipeptidyl Peptidase‐4 (DPP‐4) Inhibitor, After Single and Multiple Doses in Healthy Subjects Abstract Abstract The pharmacokinetics (PK) and pharmacodynamics (PD) of omarigliptin, a novel once‐weekly DPP‐4 inhibitor, were assessed following single an... |
PMC4312629 | core_pubmed_pmc | Pharmacokinetics of Etravirine Combined with Atazanavir/Ritonavir and a Nucleoside Reverse Transcriptase Inhibitor in Antiretroviral Treatment-Experienced, HIV-1-Infected Patients | Pharmacokinetics of Etravirine Combined with Atazanavir/Ritonavir and a Nucleoside Reverse Transcriptase Inhibitor in Antiretroviral Treatment-Experienced, HIV-1-Infected Patients Abstract Abstract Objectives . TEACH ( NCT00896051 ) was a randomized, open-label, two-arm Phase II trial to investigate the pharmacokinetic... |
PMC10525765 | core_pubmed_pmc | Impact of Continuous Kidney Replacement Therapy and Hemoadsorption with CytoSorb on Antimicrobial Drug Removal in Critically Ill Children with Septic Shock: A Single-Center Prospective Study on a Pediatric Cohort | Impact of Continuous Kidney Replacement Therapy and Hemoadsorption with CytoSorb on Antimicrobial Drug Removal in Critically Ill Children with Septic Shock: A Single-Center Prospective Study on a Pediatric Cohort Abstract Abstract Background: Extracorporeal therapies (ET) are increasingly used in pediatric settings as ... |
PMC10012935 | core_pubmed_pmc | Blueprint for antibody biologics developability | Blueprint for antibody biologics developability Abstract ABSTRACT Large-molecule antibody biologics have revolutionized medicine owing to their superior target specificity, pharmacokinetic and pharmacodynamic properties, safety and toxicity profiles, and amenability to versatile engineering. In this review, we focus on... |
PMC11181026 | core_pubmed_pmc | Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy | Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy Abstract Introduction Interleukin 15 (IL-15) is a potential anticancer agent and numerous engineered IL-15 agonists are currently under clinical investigation. Selective targetin... |
PMC12519141 | core_pubmed_pmc | Distribution of fluralaner in plasma and liver in broiler breeder hens and roosters following the administration of fluralaner (Bravecto®) via medicated drinking water | Distribution of fluralaner in plasma and liver in broiler breeder hens and roosters following the administration of fluralaner (Bravecto®) via medicated drinking water Abstract Highlight • Transcutol V was useful to enhance the water solubility of fluralaner. • 0.2 % (V/V) Transcutol V was tolerated by old broiler bree... |
PMC3666986 | core_pubmed_pmc | Similar Results in Children with Asthma for Steady State Pharmacokinetic Parameters of Ciclesonide Inhaled with or without Spacer | Similar Results in Children with Asthma for Steady State Pharmacokinetic Parameters of Ciclesonide Inhaled with or without Spacer Abstract Background: Ciclesonide is an inhaled corticosteroid administered by a metered dose inhaler (MDI) to treat bronchial asthma. After inhalation, the inactive ciclesonide is converted ... |
PMC10731752 | core_pubmed_pmc | Drug-related problems and associated factors among patients with kidney dysfunction at a tertiary hospital in southwestern Uganda: a prospective observational study | Drug-related problems and associated factors among patients with kidney dysfunction at a tertiary hospital in southwestern Uganda: a prospective observational study Abstract Abstract Background Kidney dysfunction is a common, progressive condition that is increasingly becoming a global public health issue. Because the ... |
PMC8316236 | core_pubmed_pmc | Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors | Mechanistic physiology-based pharmacokinetic modeling to elucidate vincristine-induced peripheral neuropathy following treatment with novel kinase inhibitors Abstract Abstract Purpose Limited information is available regarding the drug–drug interaction (DDI) potential of molecular targeted agents and rituximab plus cyc... |
PMC9828399 | core_pubmed_pmc | Population PK and PD Analysis of Domagrozumab in Pediatric Patients with Duchenne Muscular Dystrophy | Population PK and PD Analysis of Domagrozumab in Pediatric Patients with Duchenne Muscular Dystrophy Abstract Abstract Myostatin, a negative regulator of skeletal muscle growth, is a therapeutic target in muscle‐wasting diseases. Domagrozumab, a humanized recombinant monoclonal antibody, binds myostatin and inhibits ac... |
PMC12135532 | core_pubmed_pmc | Population pharmacokinetics of intravenous fosfomycin: dose optimization for critically ill patients with and without kidney replacement therapy | Population pharmacokinetics of intravenous fosfomycin: dose optimization for critically ill patients with and without kidney replacement therapy Abstract ABSTRACT We investigated the pharmacokinetics (PK) of intravenous fosfomycin in critically ill patients undergoing different types of kidney replacement therapy (KRT)... |
PMC9861162 | core_pubmed_pmc | Prospective Prediction of Dapaconazole Clinical Drug–Drug Interactions Using an In Vitro to In Vivo Extrapolation Equation and PBPK Modeling | Prospective Prediction of Dapaconazole Clinical Drug–Drug Interactions Using an In Vitro to In Vivo Extrapolation Equation and PBPK Modeling Abstract This study predicted dapaconazole clinical drug–drug interactions (DDIs) over the main Cytochrome P450 (CYP) isoenzymes using static (in vitro to in vivo extrapolation eq... |
PMC10106747 | core_pubmed_pmc | Addressing maternal medication use during breastfeeding using clinical resources and a novel physiologically based pharmacokinetic model-derived metric: A qualitative study | Addressing maternal medication use during breastfeeding using clinical resources and a novel physiologically based pharmacokinetic model-derived metric: A qualitative study Abstract Introduction Breastfeeding has major benefits to the maternal-infant dyad and yet healthcare providers have expressed uncertainty about ad... |
PMC5321807 | core_pubmed_pmc | Population Pharmacokinetics Modeling of Unbound Efavirenz, Atazanavir, and Ritonavir in HIV‐Infected Subjects With Aging Biomarkers | Population Pharmacokinetics Modeling of Unbound Efavirenz, Atazanavir, and Ritonavir in HIV‐Infected Subjects With Aging Biomarkers Abstract Unbound drug is the pharmacodynamically relevant concentration. This study aimed to determine if chronologic age or markers of biologic aging, such as the frailty phenotype and p1... |
PMC3383947 | core_pubmed_pmc | Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors | Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors Abstract Purpose To identify sources of exposure variability for the tumor growth inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) using a population pharmacoki... |
PMC8832337 | core_pubmed_pmc | Rituximab Concentration Varies in Patients With Different Lymphoma Subtypes and Correlates With Clinical Outcome | Rituximab Concentration Varies in Patients With Different Lymphoma Subtypes and Correlates With Clinical Outcome Abstract Individual variations in concentrations of rituximab in different B cell non-Hodgkin’s lymphoma subtypes and their relevance to efficacy were still unclear. From 2016 to 2021, a prospective clinical... |
PMC8074779 | core_pubmed_pmc | The multiple faces of ketamine in anaesthesia and analgesia | The multiple faces of ketamine in anaesthesia and analgesia Abstract Abstract Objective Ketamine is an anaesthetic agent with a unique dissociative profile and pharmacological effects ranging from the induction and maintenance of anaesthesia to analgesia and sedation, depending on the dose. This article provides inform... |
PMC8487314 | core_pubmed_pmc | Open-label phase 3 study of intravenous golimumab in patients with polyarticular juvenile idiopathic arthritis | Open-label phase 3 study of intravenous golimumab in patients with polyarticular juvenile idiopathic arthritis Abstract Abstract Objectives To assess efficacy, pharmacokinetics (PK) and safety of intravenous (i.v.) golimumab in patients with polyarticular-course JIA (pc-JIA). Methods Children aged 2 to <18 years with a... |
PMC10961409 | core_pubmed_pmc | Evaluation of physical variables, thermal nociceptive threshold testing and pharmacokinetics during placement of transdermal buprenorphine matrix-type patch in healthy adult horses | Evaluation of physical variables, thermal nociceptive threshold testing and pharmacokinetics during placement of transdermal buprenorphine matrix-type patch in healthy adult horses Abstract Background Matrix type transdermal buprenorphine patches have not been investigated in horses and may provide an effective means o... |
PMC7674781 | core_pubmed_pmc | The Pharmacokinetics of Doxycycline in Channel Catfish ( Ictalurus punctatus ) Following Intravenous and Oral Administrations | The Pharmacokinetics of Doxycycline in Channel Catfish ( Ictalurus punctatus ) Following Intravenous and Oral Administrations Abstract Abstract The objective of this study was to investigate the bioavailability (BA) and pharmacokinetics (PK) of doxycycline (DC) in channel catfish ( Ictalurus punctatus ) following a sin... |
PMC11762061 | core_pubmed_pmc | Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study | Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study Abstract Abstract Introduction Blood-brain barrier (BBB) integrity is fundamental to brain homeostasis, enabling control of s... |
PMC2928215 | core_pubmed_pmc | Compliance assessment of ambulatory Alzheimer patients to aid therapeutic decisions by healthcare professionals | Compliance assessment of ambulatory Alzheimer patients to aid therapeutic decisions by healthcare professionals Abstract Abstract Background Compliance represents a major determinant for the effectiveness of pharmacotherapy. Compliance reports summarising electronically compiled compliance data qualify healthcare needs... |
PMC3599209 | core_pubmed_pmc | Body Surface Area Predicts Plasma Oxaliplatin and Pharmacokinetic Advantage in Hyperthermic Intraoperative Intraperitoneal Chemotherapy | Body Surface Area Predicts Plasma Oxaliplatin and Pharmacokinetic Advantage in Hyperthermic Intraoperative Intraperitoneal Chemotherapy Abstract Background Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) is used to treat peritoneal surface-spreading malignancies to maximize local drug concentrations wh... |
PMC9907915 | core_pubmed_pmc | In-silico studies of inhibitory compounds against protease enzymes of SARS-CoV-2 | In-silico studies of inhibitory compounds against protease enzymes of SARS-CoV-2 Abstract Abstract In December 2019, a COVID-19 outbreak caused by SARS-CoV-2 raised worldwide health concerns. In this case, molecular docking and drug repurposing computational approaches were engaged to check the efficiency of plant-base... |
PMC10831339 | core_pubmed_pmc | Paclitaxel plus Eftilagimod Alpha, a Soluble LAG-3 Protein, in Metastatic, HR + Breast Cancer: Results from AIPAC, a Randomized, Placebo Controlled Phase IIb Trial | Paclitaxel plus Eftilagimod Alpha, a Soluble LAG-3 Protein, in Metastatic, HR + Breast Cancer: Results from AIPAC, a Randomized, Placebo Controlled Phase IIb Trial Abstract Abstract Purpose: Eftilagimod alpha (efti), a soluble lymphocyte activation gene (LAG-3) protein and MHC class II agonist, enhances innate and adap... |
PMC9808715 | core_pubmed_pmc | Lack of Clinical Relevance of Bilastine-Food Interaction in Healthy Volunteers: A Wheal and Flare Study | Lack of Clinical Relevance of Bilastine-Food Interaction in Healthy Volunteers: A Wheal and Flare Study Abstract Abstract Introduction The aim of this study was to compare the pharmacodynamic activity of bilastine administered under fasting and fed conditions in healthy volunteers. Methods In this randomized, open-labe... |
PMC11503958 | core_pubmed_pmc | Imaging-Assisted Antisense Oligonucleotide Delivery for Tumor-Targeted Gene Therapy | Imaging-Assisted Antisense Oligonucleotide Delivery for Tumor-Targeted Gene Therapy Abstract Antisense oligonucleotide (ASO) represents a class of practical tools for targeting undruggable oncogenes with several candidates currently undergoing clinical investigation. The advancement of antisense therapeutics necessitat... |
PMC5980459 | core_pubmed_pmc | Pharmacokinetics and efficacy of intravenous famotidine in adult cattle | Pharmacokinetics and efficacy of intravenous famotidine in adult cattle Abstract Background Abomasal ulceration is recognized in neonatal and adult cattle, but research regarding treatment is limited. Histamine‐2 receptor antagonists (H 2 RA), such as famotidine, are used clinically with little evidence‐based research ... |
PMC11129016 | core_pubmed_pmc | Thromboembolic prevention in athletes: management of anticoagulation in sports players affected by atrial fibrillation | Thromboembolic prevention in athletes: management of anticoagulation in sports players affected by atrial fibrillation Abstract Abstract Atrial fibrillation (AF) is a common cardiac arrhythmia that poses a significant risk of stroke and thromboembolic events. Anticoagulation therapy is essential for preventing stroke i... |
PMC6804073 | core_pubmed_pmc | Interaction Effects between Doxorubicin and Hernandezine on the Pharmacokinetics by Liquid Chromatography Coupled with Mass Spectrometry | Interaction Effects between Doxorubicin and Hernandezine on the Pharmacokinetics by Liquid Chromatography Coupled with Mass Spectrometry Abstract Abstract Doxorubicin (DOX) is an effective anti-tumor drug widely used in clinics. Hernandezine (HER), isolated from a Chinese medicinal herb, has a selective inhibitory effe... |
PMC7714761 | core_pubmed_pmc | Understanding Volume Kinetics: The Role of Pharmacokinetic Modeling and Analysis in Fluid Therapy | Understanding Volume Kinetics: The Role of Pharmacokinetic Modeling and Analysis in Fluid Therapy Abstract Fluid therapy is a rapidly evolving yet imprecise clinical practice based upon broad assumptions, species-to-species extrapolations, obsolete experimental evidence, and individual preferences. Although widely reco... |
PMC12232703 | core_pubmed_pmc | Herb-drug interactions in oncology: pharmacodynamic/pharmacokinetic mechanisms and risk prediction | Herb-drug interactions in oncology: pharmacodynamic/pharmacokinetic mechanisms and risk prediction Abstract The prevalence of herbal medicines has gained widespread, particularly among cancer patients seeking adjunctive therapies. Co-administered with anticancer drugs (ACDs) frequently, herbal medicines result in incre... |
PMC7354398 | core_pubmed_pmc | The Edoxaban Hokusai VTE PEDIATRICS Study: An open‐label, multicenter, randomized study of edoxaban for pediatric venous thromboembolic disease | The Edoxaban Hokusai VTE PEDIATRICS Study: An open‐label, multicenter, randomized study of edoxaban for pediatric venous thromboembolic disease Abstract Abstract Background Little evidence is available for treatment of pediatric venous thromboembolism (VTE). Large randomized controlled trials are challenging in childre... |
PMC2880414 | core_pubmed_pmc | Non-compartment model to compartment model pharmacokinetics transformation meta-analysis – a multivariate nonlinear mixed model | Non-compartment model to compartment model pharmacokinetics transformation meta-analysis – a multivariate nonlinear mixed model Abstract Abstract Background To fulfill the model based drug development, the very first step is usually a model establishment from published literatures. Pharmacokinetics model is the central... |
PMC9348130 | core_pubmed_pmc | Development of novel ultra-sensitive IL-11 target engagement assays to support mechanistic PK/PD modeling for an anti-IL-11 antibody therapeutic | Development of novel ultra-sensitive IL-11 target engagement assays to support mechanistic PK/PD modeling for an anti-IL-11 antibody therapeutic Abstract ABSTRACT An in-house antibody generation campaign identified a diverse, high affinity set of anti-interleukin-11 (IL-11) monoclonal antibodies (mAbs) to enable succes... |
PMC11897560 | core_pubmed_pmc | Monte Carlo simulation to optimize polymyxin B dosing regimens for the treatment of Gram-negative bacteremia | Monte Carlo simulation to optimize polymyxin B dosing regimens for the treatment of Gram-negative bacteremia Abstract Objective This study aimed to predict and evaluate the efficacy of various polymyxin B dosing regimens for Gram-negative bacteremia using Monte Carlo simulation, with a specific focus on assessing the e... |
PMC9266449 | core_pubmed_pmc | Dried Blood Spots as Matrix for Evaluation of Valproate Levels and the Immediate and Delayed Metabolomic Changes Induced by Single Valproate Dose Treatment | Dried Blood Spots as Matrix for Evaluation of Valproate Levels and the Immediate and Delayed Metabolomic Changes Induced by Single Valproate Dose Treatment Abstract Abstract The immediate and delayed metabolic changes in rats treated with valproate (VPA), a drug used for the treatment of epilepsy, were profiled. An est... |
PMC6831770 | core_pubmed_pmc | Effect of Pterostilbene, a Natural Analog of Resveratrol, on the Activity of some Antiepileptic Drugs in the Acute Seizure Tests in Mice | Effect of Pterostilbene, a Natural Analog of Resveratrol, on the Activity of some Antiepileptic Drugs in the Acute Seizure Tests in Mice Abstract Pterostilbene (PTE), a natural analog of resveratrol, is available both as a diet ingredient and a dietary supplement. The present study was undertaken to assess the effect o... |
PMC4407414 | core_pubmed_pmc | Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®) | Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®) Abstract Abstract Background Artemether-lumefantrine (AL) dispersible formulation was developed for the treatment of uncomplicated Plas... |
PMC6901793 | core_pubmed_pmc | Status of Recombinant Factor VIII Concentrate Treatment for Hemophilia A in Italy: Characteristics and Clinical Benefits | Status of Recombinant Factor VIII Concentrate Treatment for Hemophilia A in Italy: Characteristics and Clinical Benefits Abstract Abstract The current interest in recombinant factor VIII (rFVIII) products stems from the fact that they offer a technological solution to prolonging the half-life of and reducing the risk o... |
PMC8417876 | core_pubmed_pmc | Pharmacodynamics and Pharmacokinetics of Injectable Pimobendan and Its Metabolite, O-Desmethyl-Pimobendan, in Healthy Dogs | Pharmacodynamics and Pharmacokinetics of Injectable Pimobendan and Its Metabolite, O-Desmethyl-Pimobendan, in Healthy Dogs Abstract Objectives: This study was designed to thoroughly evaluate the effects of bolus pimobendan at a dose of 0.15 mg/kg on cardiac functions, hemodynamics, and electrocardiographic parameters t... |
PMC10014699 | core_pubmed_pmc | The randomized, single‐ and multiple‐ ascending dose studies of the safety, tolerability, pharmacokinetics of CSPCHA115 in healthy Chinese subjects | The randomized, single‐ and multiple‐ ascending dose studies of the safety, tolerability, pharmacokinetics of CSPCHA115 in healthy Chinese subjects Abstract Abstract CSPCHA115 is a highly selective and potent antagonist of chemoattractant receptor‐homologous molecule expressed on TH2 cells (CRTH2). This study aimed to ... |
PMC11859694 | core_pubmed_pmc | Bioconjugation of Podophyllotoxin and Nanosystems: Approaches for Boosting Its Biopharmaceutical and Antitumoral Profile | Bioconjugation of Podophyllotoxin and Nanosystems: Approaches for Boosting Its Biopharmaceutical and Antitumoral Profile Abstract Abstract Podophyllotoxin is a natural compound belonging to the lignan family and is well-known for its great antitumor activity. However, it shows several limitations, such as severe side e... |
PMC9026419 | core_pubmed_pmc | Repeated-Dose Pharmacodynamics of Pimobendan in Healthy Cats | Repeated-Dose Pharmacodynamics of Pimobendan in Healthy Cats Abstract Abstract Simple Summary The dosing of pimobendan in cats is determined with reference to the effects of a single dose, although pimobendan is normally administered in repeated doses. In this study, the pharmacodynamics of repeated and multiple-dose p... |
PMC12816428 | core_pubmed_pmc | Model‐Informed Deep Q‐Networks to Guide Infliximab Dosing in Pediatric Crohn’s Disease | Model‐Informed Deep Q‐Networks to Guide Infliximab Dosing in Pediatric Crohn’s Disease Abstract Abstract Model‐informed precision dosing (MIPD) utilizes pharmacokinetic/pharmacodynamic (PK/PD) models to optimize drug therapy. However, conventional MIPD often requires manual simulation and regimen selection, which are t... |
PMC8267123 | core_pubmed_pmc | Preoperative histogram parameters of dynamic contrast‐enhanced MRI as a potential imaging biomarker for assessing the expression of Ki‐67 in prostate cancer | Preoperative histogram parameters of dynamic contrast‐enhanced MRI as a potential imaging biomarker for assessing the expression of Ki‐67 in prostate cancer Abstract Abstract Purpose To investigate whether preoperative histogram parameters of dynamic contrast‐enhanced MRI (DCE‐MRI) can assess the expression of Ki‐67 in... |
PMC9060532 | core_pubmed_pmc | Pharmacokinetic profile and metabolite identification of bornyl caffeate and caffeic acid in rats by high performance liquid chromatography coupled with mass spectrometry † | Pharmacokinetic profile and metabolite identification of bornyl caffeate and caffeic acid in rats by high performance liquid chromatography coupled with mass spectrometry † Abstract Bornyl caffeate was initially discovered as a bioactive compound in medicinal plants. Despite the promising pharmacological activities inc... |
PMC4203516 | core_pubmed_pmc | Combined MTOR and autophagy inhibition | Combined MTOR and autophagy inhibition Abstract The combination of temsirolimus (TEM), an MTOR inhibitor, and hydroxychloroquine (HCQ), an autophagy inhibitor, augments cell death in preclinical models. This phase 1 dose-escalation study evaluated the maximum tolerated dose (MTD), safety, preliminary activity, pharmaco... |
PMC11836065 | core_pubmed_pmc | Associations of long-term exposure to nitrogen oxides with all-cause and cause-specific mortality | Associations of long-term exposure to nitrogen oxides with all-cause and cause-specific mortality Abstract Associations between long-term exposure to nitrogen oxides (NO x ) and cause-specific mortality remain insufficiently explored. This study utilizes data from 502,040 participants registered in the UK Biobank. Time... |
PMC7066271 | core_pubmed_pmc | A drug–drug interaction study of a novel, selective urate reabsorption inhibitor dotinurad and the non-steroidal anti-inflammatory drug oxaprozin in healthy adult males | A drug–drug interaction study of a novel, selective urate reabsorption inhibitor dotinurad and the non-steroidal anti-inflammatory drug oxaprozin in healthy adult males Abstract Background Dotinurad is a novel, selective urate reabsorption inhibitor, which reduces serum uric acid levels by inhibiting the urate transpor... |
PMC8021041 | core_pubmed_pmc | Knowledge, Perception, and Antibiotic Prescribing Practice in the Intensive Care Unit: Findings from the Malaysian Public Setting | Knowledge, Perception, and Antibiotic Prescribing Practice in the Intensive Care Unit: Findings from the Malaysian Public Setting Abstract A BSTRACT Introduction: Approach to managing infection in the intensive care unit (ICU) often varies between institutions and not many readily adapt to available local guidelines de... |
PMC12256690 | core_pubmed_pmc | Use of Model‐Based Meta‐Analysis to Inform the Design of Early Clinical Trials of Anti‐Amyloid Beta Therapies in Alzheimer's Disease | Use of Model‐Based Meta‐Analysis to Inform the Design of Early Clinical Trials of Anti‐Amyloid Beta Therapies in Alzheimer's Disease Abstract ABSTRACT To inform an efficient development of new investigational anti‐amyloid beta (anti‐Aβ) monoclonal antibodies (mAbs), a modeling‐and‐simulation‐based strategy was proposed... |
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