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PMC8778328 | core_pubmed_pmc | Development of 3D-Printed, Liquisolid and Directly Compressed Glimepiride Tablets, Loaded with Black Seed Oil Self-Nanoemulsifying Drug Delivery System: In Vitro and In Vivo Characterization | Development of 3D-Printed, Liquisolid and Directly Compressed Glimepiride Tablets, Loaded with Black Seed Oil Self-Nanoemulsifying Drug Delivery System: In Vitro and In Vivo Characterization Abstract Abstract Glimepiride is characterized by an inconsistent dissolution and absorption profile due to its limited aqueous s... |
PMC3553413 | core_pubmed_pmc | A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma | A phase 1 dose-escalating study of pegylated recombinant human arginase 1 (Peg-rhArg1) in patients with advanced hepatocellular carcinoma Abstract Summary Background Hepatocellular carcinoma (HCC) cells are auxotrophic for arginine, depletion of which leads to tumour regression. The current study evaluated safety, phar... |
PMC5825125 | core_pubmed_pmc | A new high-performance liquid chromatography-tandem mass spectrometry method for the determination of paclitaxel and 6α-hydroxy-paclitaxel in human plasma: Development, validation and application in a clinical pharmacokinetic study | A new high-performance liquid chromatography-tandem mass spectrometry method for the determination of paclitaxel and 6α-hydroxy-paclitaxel in human plasma: Development, validation and application in a clinical pharmacokinetic study Abstract Abstract Paclitaxel belongs to the taxanes family and it is used, alone or in m... |
PMC6533487 | core_pubmed_pmc | Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic‐pharmacodynamic analysis of cinacalcet | Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic‐pharmacodynamic analysis of cinacalcet Abstract Aims The aims of this study were to develop a pharmacokinetic (PK) and PK‐pharmacodynamic (PK/PD) model of cinacalcet in adults and paediatrics with secondary hyp... |
PMC5764290 | core_pubmed_pmc | Safety and efficacy of subcutaneous tanezumab in patients with knee or hip osteoarthritis | Safety and efficacy of subcutaneous tanezumab in patients with knee or hip osteoarthritis Abstract Background/objective The objective of this study was to investigate the safety and efficacy of subcutaneous (SC) and intravenous (IV) tanezumab administration in osteoarthritis (OA) patients. Materials and methods Study 1... |
PMC3848953 | core_pubmed_pmc | A continuous-time adaptive particle filter for estimations under measurement time uncertainties with an application to a plasma-leucine mixed effects model | A continuous-time adaptive particle filter for estimations under measurement time uncertainties with an application to a plasma-leucine mixed effects model Abstract Background When mathematical modelling is applied to many different application areas, a common task is the estimation of states and parameters based on me... |
PMC9249714 | core_pubmed_pmc | Filgotinib: A Clinical Pharmacology Review | Filgotinib: A Clinical Pharmacology Review Abstract Abstract Filgotinib (GS-6034, formerly GLPG0634; Jyseleca ® ) is an oral, preferential Janus kinase (JAK)-1 inhibitor. Preferential inhibition of JAK1 modulates a subset of proinflammatory cytokines within the JAK–signal transducer and activator of transcription pathw... |
PMC9029174 | core_pubmed_pmc | Population Pharmacokinetic Model of Piperacillin in Critically Ill Patients and Describing Interethnic Variation Using External Validation | Population Pharmacokinetic Model of Piperacillin in Critically Ill Patients and Describing Interethnic Variation Using External Validation Abstract Abstract Objectives: This study aimed to develop a piperacillin population PK model for critically ill Brazil-ian patients and describe interethnic variation using an exter... |
PMC10196416 | core_pubmed_pmc | Mechanistic modeling of ophthalmic, nasal, injectable, and implant generic drug products: A workshop summary report | Mechanistic modeling of ophthalmic, nasal, injectable, and implant generic drug products: A workshop summary report Abstract Abstract For approval, a proposed generic drug product must demonstrate it is bioequivalent (BE) to the reference listed drug product. For locally acting drug products, conventional BE approaches... |
PMC8965498 | core_pubmed_pmc | Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy | Multifunctional co-transport carriers based on cyclodextrin assembly for cancer synergistic therapy Abstract In the past few years, drug delivery systems have been used extensively to improve solubility, stability, and pharmacokinetics of chemotherapeutic drugs. However, traditional delivery systems fail to fulfill the... |
PMC7577019 | core_pubmed_pmc | Population Pharmacodynamic Modeling of Epoetin Alfa in End‐Stage Renal Disease Patients Receiving Maintenance Treatment Using Bayesian Approach | Population Pharmacodynamic Modeling of Epoetin Alfa in End‐Stage Renal Disease Patients Receiving Maintenance Treatment Using Bayesian Approach Abstract The ability to control dosage regimens of erythropoiesis‐stimulating agents (ESAs) to maintain a desired hemoglobin (HGB) target is still elusive. We utilized a Bayesi... |
PMC12466373 | core_pubmed_pmc | Length and Type of Antibiotic Prophylaxis for Infection Prevention in Adults Patient in the Cardiac Surgery Intensive Care Unit: A Narrative Review | Length and Type of Antibiotic Prophylaxis for Infection Prevention in Adults Patient in the Cardiac Surgery Intensive Care Unit: A Narrative Review Abstract Abstract Background: Infections following cardiac surgery are a significant cause of morbidity and mortality, particularly in intensive care units (ICUs). The role... |
PMC6302998 | core_pubmed_pmc | Drug-Drug Interactions, Safety, and Pharmacokinetics of EGFR Tyrosine Kinase Inhibitors for the Treatment of Non–Small Cell Lung Cancer | Drug-Drug Interactions, Safety, and Pharmacokinetics of EGFR Tyrosine Kinase Inhibitors for the Treatment of Non–Small Cell Lung Cancer Abstract Inhibitors of the epidermal growth factor receptor (EGFR) are important treatment options for non–small cell lung cancer (NSCLC) patients with activating EGFR mutations. Erlot... |
PMC7759250 | core_pubmed_pmc | Pharmacokinetic interaction study between ligustrazine and valsartan in rats and its potential mechanism | Pharmacokinetic interaction study between ligustrazine and valsartan in rats and its potential mechanism Abstract Abstract Context Ligustrazine and valsartan are commonly used drugs in the treatment of cardiac and cardiovascular disease. Objective The interaction between ligustrazine and valsartan was studied to invest... |
PMC9099121 | core_pubmed_pmc | Population pharmacokinetic and exposure‐response analyses from ALTA‐1L: Model‐based analyses supporting the brigatinib dose in ALK ‐positive NSCLC | Population pharmacokinetic and exposure‐response analyses from ALTA‐1L: Model‐based analyses supporting the brigatinib dose in ALK ‐positive NSCLC Abstract Abstract The ALK in Lung Cancer Trial of brigAtinib in First Line (ALTA‐1L) compared brigatinib versus crizotinib in anaplastic lymphoma kinase (ALK) inhibitor‐naiv... |
PMC9023358 | core_pubmed_pmc | Kinetics of Bacterial Adaptation, Growth, and Death at Didecyldimethylammonium Chloride sub-MIC Concentrations | Kinetics of Bacterial Adaptation, Growth, and Death at Didecyldimethylammonium Chloride sub-MIC Concentrations Abstract Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) are standard indexes for determining disinfection effectiveness. Nevertheless, they are static values disregarding t... |
PMC8647170 | core_pubmed_pmc | Development and Validation of an HPLC-UV Method for Quantitation of Linezolid: Application to Resistance Study Using in vitro PK/PD Model | Development and Validation of an HPLC-UV Method for Quantitation of Linezolid: Application to Resistance Study Using in vitro PK/PD Model Abstract Abstract Background Linezolid (LNZ), an oxazolidinone antibiotic, has 100% oral bioavailability and favorable activities against gram-positive pathogens. The in vitro PK/PD ... |
PMC4266807 | core_pubmed_pmc | Reverse pharmacology for developing an anti-malarial phytomedicine. The example of Argemone mexicana | Reverse pharmacology for developing an anti-malarial phytomedicine. The example of Argemone mexicana Abstract Highlights • The conventional drug discovery approach is compared with the reverse pharmacology process. • Argemone mexicana is used as a case study. • A reverse pharmacology approach is presented for the treat... |
PMC12691696 | core_pubmed_pmc | Optimizing phage-antibiotic combinations: impact of administration order against daptomycin non-susceptible (DNS) MRSA clinical isolates | Optimizing phage-antibiotic combinations: impact of administration order against daptomycin non-susceptible (DNS) MRSA clinical isolates Abstract ABSTRACT The rise of bacterial resistance has driven the exploration of novel therapies, such as bacteriophage-antibiotic cocktails (PACs), which have shown in vitro promise ... |
PMC10954342 | core_pubmed_pmc | Pharmacokinetics and Optimal Dosing of Levofloxacin in Children for Drug-Resistant Tuberculosis: An Individual Patient Data Meta-Analysis | Pharmacokinetics and Optimal Dosing of Levofloxacin in Children for Drug-Resistant Tuberculosis: An Individual Patient Data Meta-Analysis Abstract Abstract Background Each year 25 000–32 000 children develop rifampicin- or multidrug-resistant tuberculosis (RR/MDR-TB), and many more require preventive treatment. Levoflo... |
PMC10668724 | core_pubmed_pmc | Real-Life Vancomycin Therapeutic Drug Monitoring in Coagulase-Negative Staphylococcal Bacteremia in Neonatal and Pediatric Intensive Care Unit: Are We Underestimating Augmented Renal Clearance? | Real-Life Vancomycin Therapeutic Drug Monitoring in Coagulase-Negative Staphylococcal Bacteremia in Neonatal and Pediatric Intensive Care Unit: Are We Underestimating Augmented Renal Clearance? Abstract Bloodstream infections (BSI) from coagulase-negative-staphylococci (CoNS) are among the most frequent healthcare-rela... |
PMC8878512 | core_pubmed_pmc | Need for Expansion of Pharmacy Education Globally for the Growing Field of Nanomedicine | Need for Expansion of Pharmacy Education Globally for the Growing Field of Nanomedicine Abstract Abstract The emerging landscape of nanomedicine includes a wide variety of active pharmaceutical ingredients and drug formulations. Their design provides nanomedicines with unique features leading to improved pharmacokineti... |
PMC6599298 | core_pubmed_pmc | Evaluation of systemic absorption and bronchodilator effect of glycopyrronium bromide delivered by nebulizer or a dry powder inhaler in subjects with chronic obstructive pulmonary disease | Evaluation of systemic absorption and bronchodilator effect of glycopyrronium bromide delivered by nebulizer or a dry powder inhaler in subjects with chronic obstructive pulmonary disease Abstract Abstract Background Effective bronchodilator therapy depends upon adequate drug deposition in the lung. COPD patients who a... |
PMC4732515 | core_pubmed_pmc | Evaluation of the pharmacokinetic equivalence and 54-week efficacy and safety of CT-P13 and innovator infliximab in Japanese patients with rheumatoid arthritis | Evaluation of the pharmacokinetic equivalence and 54-week efficacy and safety of CT-P13 and innovator infliximab in Japanese patients with rheumatoid arthritis Abstract Abstract Objectives. To demonstrate the pharmacokinetic equivalence of CT-P13 and its innovator infliximab (IFX) in Japanese patients with rheumatoid a... |
PMC6016261 | core_pubmed_pmc | Kidney-targeted drug delivery via rhein-loaded polyethyleneglycol- co -polycaprolactone- co -polyethylenimine nanoparticles for diabetic nephropathy therapy | Kidney-targeted drug delivery via rhein-loaded polyethyleneglycol- co -polycaprolactone- co -polyethylenimine nanoparticles for diabetic nephropathy therapy Abstract Abstract Introduction Diabetic nephropathy (DN) is the primary root of morbidity and mortality in diabetic patients. Unfortunately, currently, no effectiv... |
PMC9511178 | core_pubmed_pmc | Lung cancer with brain metastases remaining in continuous complete remission due to pembrolizumab and temozolomide: a case report | Lung cancer with brain metastases remaining in continuous complete remission due to pembrolizumab and temozolomide: a case report Abstract Abstract Background Immunotherapy has been shown to improve the overall survival (OS) in patients with advanced or metastatic non-small cell lung cancer (NSCLC) without driver gene ... |
PMC9322370 | core_pubmed_pmc | Predictiveness of the Human-CYP3A4-Transgenic Mouse Model (Cyp3aXAV) for Human Drug Exposure of CYP3A4-Metabolized Drugs | Predictiveness of the Human-CYP3A4-Transgenic Mouse Model (Cyp3aXAV) for Human Drug Exposure of CYP3A4-Metabolized Drugs Abstract Abstract The extrapolation of drug exposure between species remains a challenging step in drug development, contributing to the low success rate of drug approval. As a consequence, extrapola... |
PMC12436384 | core_pubmed_pmc | Population pharmacokinetic modeling of dexmedetomidine nasal spray in Chinese adults | Population pharmacokinetic modeling of dexmedetomidine nasal spray in Chinese adults Abstract Objective The main objective was to build and qualify a population pharmacokinetic (PopPK) model for dexmedetomidine nasal spray in Chinese adults and explore the covariates affecting the PopPK model parameters. Methods A popu... |
PMC7417630 | core_pubmed_pmc | In vitro Activity of Robenidine Analog NCL195 in Combination With Outer Membrane Permeabilizers Against Gram-Negative Bacterial Pathogens and Impact on Systemic Gram-Positive Bacterial Infection in Mice | In vitro Activity of Robenidine Analog NCL195 in Combination With Outer Membrane Permeabilizers Against Gram-Negative Bacterial Pathogens and Impact on Systemic Gram-Positive Bacterial Infection in Mice Abstract Multidrug-resistant (MDR) pathogens, particularly the ESKAPE group ( Enterococcus faecalis/faecium , Staphyl... |
PMC7457137 | core_pubmed_pmc | An Integrated Pharmacokinetic Study of an Acanthopanax senticosus Extract Preparation by Combination of Virtual Screening, Systems Pharmacology, and Multi-Component Pharmacokinetics in Rats | An Integrated Pharmacokinetic Study of an Acanthopanax senticosus Extract Preparation by Combination of Virtual Screening, Systems Pharmacology, and Multi-Component Pharmacokinetics in Rats Abstract In this paper, the integrated pharmacokinetics (PK) of an Acanthopanax senticosus extract preparation (ASEP, named as Ciw... |
PMC8832278 | core_pubmed_pmc | Human Microbiota and Immunotherapy in Breast Cancer - A Review of Recent Developments | Human Microbiota and Immunotherapy in Breast Cancer - A Review of Recent Developments Abstract Breast cancer (BC) is the most common malignancy and the second cause of cancer-specific death in women from high-income countries. Infectious agents are the third most important risk factor for cancer incidence after tobacco... |
PMC10366102 | core_pubmed_pmc | Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib | Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib Abstract Abstract Samuraciclib is a selective oral CDK7-inhibitor. A multi-modular, open-label Phase I study to evaluate safety and tolerability of samuraciclib in patients with advanced m... |
PMC11579122 | core_pubmed_pmc | Population pharmacokinetic analyses of pozelimab in patients with CD55-deficient protein-losing enteropathy (CHAPLE disease) | Population pharmacokinetic analyses of pozelimab in patients with CD55-deficient protein-losing enteropathy (CHAPLE disease) Abstract Abstract Pozelimab, a monoclonal antibody directed against C5, is the first and only treatment for adult and pediatric patients (≥ 1 year) with CD55-deficient protein-losing enteropathy ... |
PMC5315062 | core_pubmed_pmc | Liquid Chromatography–Mass Spectrometry/Mass Spectrometry Analysis and Pharmacokinetic Assessment of Ponatinib in Sprague–Dawley Rats | Liquid Chromatography–Mass Spectrometry/Mass Spectrometry Analysis and Pharmacokinetic Assessment of Ponatinib in Sprague–Dawley Rats Abstract Introduction By means of liquid–liquid extraction with ethyl acetate, a rapid, sensitive, and specific LC–MS/MS method was developed and validated for assaying ponatinib and the... |
PMC12692354 | core_pubmed_pmc | CPX-351 and the Frontier of Nanoparticle-Based Therapeutics in Acute Myeloid Leukemia | CPX-351 and the Frontier of Nanoparticle-Based Therapeutics in Acute Myeloid Leukemia Abstract Acute myeloid leukemia (AML) continues to carry a dismal prognosis in older adults and those with secondary or high-risk disease, where conventional 7 + 3 chemotherapy has long delivered complete remission rates below 40% and... |
PMC12655527 | core_pubmed_pmc | An Investigational Study on the Role of ADME Agents’ Genetic Variation on DD217 Pharmacokinetics and Safety Profile | An Investigational Study on the Role of ADME Agents’ Genetic Variation on DD217 Pharmacokinetics and Safety Profile Abstract Background/Objectives : Direct oral anticoagulants (DOACs) have transformed the prevention of thromboembolic events, but their efficacy and safety remain highly variable across individuals. DD217... |
PMC11945841 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Models for Infliximab, Ipilimumab, and Nivolumab Developed with GastroPlus to Predict Hepatic Concentrations | Physiologically Based Pharmacokinetic Models for Infliximab, Ipilimumab, and Nivolumab Developed with GastroPlus to Predict Hepatic Concentrations Abstract Background/Objectives: Infliximab, ipilimumab, and nivolumab are three monoclonal antibodies that have been associated with hepatotoxicity. Three separate physiolog... |
PMC12184040 | core_pubmed_pmc | Biofluid biomarker changes following treatment with sabirnetug (ACU193) in INTERCEPT-AD, a phase 1 trial in early Alzheimer's disease | Biofluid biomarker changes following treatment with sabirnetug (ACU193) in INTERCEPT-AD, a phase 1 trial in early Alzheimer's disease Abstract Abstract Objective Sabirnetug (ACU193) is a humanized monoclonal antibody selective for soluble amyloid beta oligomers (AβOs), synaptotoxins that are early and persistent trigge... |
PMC3743865 | core_pubmed_pmc | The FLT3 Inhibitor Quizartinib Inhibits ABCG2 at Pharmacologically Relevant Concentrations, with Implications for Both Chemosensitization and Adverse Drug Interactions | The FLT3 Inhibitor Quizartinib Inhibits ABCG2 at Pharmacologically Relevant Concentrations, with Implications for Both Chemosensitization and Adverse Drug Interactions Abstract The oral second-generation bis-aryl urea fms-like tyrosine kinase 3 (FLT3) inhibitor quizartinib (AC220) has favorable kinase selectivity and p... |
PMC11807913 | core_pubmed_pmc | Evaluating the Usefulness of Online Tools for Detecting Inappropriate Prescriptions in the Geriatric Population at a Tertiary Care Teaching Hospital in Central India: A Retrospective Study | Evaluating the Usefulness of Online Tools for Detecting Inappropriate Prescriptions in the Geriatric Population at a Tertiary Care Teaching Hospital in Central India: A Retrospective Study Abstract The elderly population differs from adults because they have numerous comorbid conditions and pharmacokinetics and pharmac... |
PMC4954841 | core_pubmed_pmc | Analysis of peginterferon β-1a exposure and Gd-enhanced lesion or T2 lesion response in relapsing-remitting multiple sclerosis patients | Analysis of peginterferon β-1a exposure and Gd-enhanced lesion or T2 lesion response in relapsing-remitting multiple sclerosis patients Abstract Abstract The effect of subcutaneous (SC) peginterferon β-1a exposure on reduction of gadolinium-enhanced (Gd+) lesion count over time was evaluated in patients with relapsing-... |
PMC8225009 | core_pubmed_pmc | Zebrafish, an In Vivo Platform to Screen Drugs and Proteins for Biomedical Use | Zebrafish, an In Vivo Platform to Screen Drugs and Proteins for Biomedical Use Abstract Abstract The nearly simultaneous convergence of human genetics and advanced molecular technologies has led to an improved understanding of human diseases. At the same time, the demand for drug screening and gene function identificat... |
PMC8703684 | core_pubmed_pmc | Negligible Effect of Quercetin in the Pharmacokinetics of Sulfasalazine in Rats and Beagles: Metabolic Inactivation of the Interaction Potential of Quercetin with BCRP | Negligible Effect of Quercetin in the Pharmacokinetics of Sulfasalazine in Rats and Beagles: Metabolic Inactivation of the Interaction Potential of Quercetin with BCRP Abstract Breast cancer resistance protein (BCRP) mediates pharmacokinetic drug interactions. This study evaluated the potential of quercetin to inhibit ... |
PMC10304832 | core_pubmed_pmc | The Pharmacokinetic and Absolute Bioavailability of Cyclosporine (Atopica for Cats ® ) in Cats | The Pharmacokinetic and Absolute Bioavailability of Cyclosporine (Atopica for Cats ® ) in Cats Abstract Simple Summary This study aimed to evaluate the rate and amount of cyclosporine A in cats following oral administration using intravenous administration as a reference. Twenty-four healthy cats were selected and rand... |
PMC8636140 | core_pubmed_pmc | Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs | Population Pharmacokinetics of Intravenous Amoxicillin Combined With Clavulanic Acid in Healthy and Critically Ill Dogs Abstract Background: Data regarding antimicrobial pharmacokinetics (PK) in critically ill dogs are lacking and likely differ from those of healthy dogs. The aim of this work is to describe a populatio... |
PMC4456123 | core_pubmed_pmc | Switching from rivaroxaban to warfarin: an open label pharmacodynamic study in healthy subjects | Switching from rivaroxaban to warfarin: an open label pharmacodynamic study in healthy subjects Abstract Abstract Aims The primary objective was to explore the pharmacodynamic changes during transition from rivaroxaban to warfarin in healthy subjects. Safety, tolerability and pharmacokinetics were assessed as secondary... |
PMC5049675 | core_pubmed_pmc | Pharmacodynamics and tolerability of repository corticotropin injection in healthy human subjects: A comparison with intravenous methylprednisolone | Pharmacodynamics and tolerability of repository corticotropin injection in healthy human subjects: A comparison with intravenous methylprednisolone Abstract Abstract Repository corticotropin injection (porcine adrenocorticotropic hormone [ACTH] analog) and intravenous methylprednisolone (IVMP) are used to treat inflamm... |
PMC8959092 | core_pubmed_pmc | Patient-derived tumor models are attractive tools to repurpose drugs for ovarian cancer treatment: pre-clinical updates | Patient-derived tumor models are attractive tools to repurpose drugs for ovarian cancer treatment: pre-clinical updates Abstract Despite advances in understanding of ovarian cancer biology, the progress in translation of research findings into new therapies is still slow. It is associated in part with limitations of co... |
PMC11762427 | core_pubmed_pmc | A Review of Vancomycin, Gentamicin, and Amikacin Population Pharmacokinetic Models in Neonates and Infants | A Review of Vancomycin, Gentamicin, and Amikacin Population Pharmacokinetic Models in Neonates and Infants Abstract Population pharmacokinetic (popPK) models are an essential tool when implementing therapeutic drug monitoring (TDM) and to overcome dosing challenges in neonates in clinical practice. Since vancomycin, ge... |
PMC10551744 | core_pubmed_pmc | Quantification of OATP1B1 endogenous metabolites coproporphyrin I and III in human urine | Quantification of OATP1B1 endogenous metabolites coproporphyrin I and III in human urine Abstract Coproporphyrin (CP)-I and CP-III are the markers of organic anion-transporting polypeptides’ (OATPs) activities, and they are porphyrin metabolites that originate from heme synthesis. Furthermore, CP-I and CP-III, which ar... |
PMC5516711 | core_pubmed_pmc | Pharmacokinetics of Caffeic Acid, Ferulic Acid, Formononetin, Cryptotanshinone, and Tanshinone IIA after Oral Administration of Naoxintong Capsule in Rat by HPLC-MS/MS | Pharmacokinetics of Caffeic Acid, Ferulic Acid, Formononetin, Cryptotanshinone, and Tanshinone IIA after Oral Administration of Naoxintong Capsule in Rat by HPLC-MS/MS Abstract Abstract Naoxintong capsule (NXTC) was a famous patent medicine of Traditional Chinese Medicine (TCM) to treat cerebrovascular diseases in Chin... |
PMC10465907 | core_pubmed_pmc | Initial dosage optimisation of cyclosporine in Chinese paediatric patients undergoing allogeneic haematopoietic stem cell transplantation based on population pharmacokinetics: a retrospective study | Initial dosage optimisation of cyclosporine in Chinese paediatric patients undergoing allogeneic haematopoietic stem cell transplantation based on population pharmacokinetics: a retrospective study Abstract Objective Improved understanding of cyclosporine A (CsA) pharmacokinetics in children undergoing allogeneic haema... |
PMC9601332 | core_pubmed_pmc | The Pharmacogenetics of Cannabis in the Treatment of Chronic Pain | The Pharmacogenetics of Cannabis in the Treatment of Chronic Pain Abstract Background: The increase in the medical use of cannabis has revealed a number of beneficial effects, a variety of adverse side effects and great inter-individual variability. Association studies connecting consumption, addiction and side effects... |
PMC3271533 | core_pubmed_pmc | Pharmacokinetics of venlafaxine and its major metabolite o-desmethylvenlafaxine in freely moving mice using automated dosing/sampling system | Pharmacokinetics of venlafaxine and its major metabolite o-desmethylvenlafaxine in freely moving mice using automated dosing/sampling system Abstract Objective: To assess the pharmacokinetics of venlafaxine (VEN) and its major metabolite o-desmethylvenlafaxine (ODV) in freely moving mice using automated dosing/infusion... |
PMC10986598 | core_pubmed_pmc | Investigating inhibitors of 1-deoxy- d -xylulose 5-phosphate synthase in a mouse model of UTI | Investigating inhibitors of 1-deoxy- d -xylulose 5-phosphate synthase in a mouse model of UTI Abstract ABSTRACT The rising rate of antimicrobial resistance continues to threaten global public health. Further hastening antimicrobial resistance is the lack of new antibiotics against new targets. The bacterial enzyme, 1-d... |
PMC11375721 | core_pubmed_pmc | Bioorthogonal Diels–Alder Click Chemistry-Based Pretargeted PET Imaging Strategy for Monitoring Programmed Death-Ligand 1 Expression | Bioorthogonal Diels–Alder Click Chemistry-Based Pretargeted PET Imaging Strategy for Monitoring Programmed Death-Ligand 1 Expression Abstract Abstract The development of antibody tracers for positron emission tomography (PET) imaging enables real-time monitoring of tumor expression of programmed cell death ligand 1 (PD... |
PMC5259911 | core_pubmed_pmc | The impact of torasemide on haemodynamic and neurohormonal stress, and cardiac remodelling in heart failure – TORNADO: a study protocol for a randomized controlled trial | The impact of torasemide on haemodynamic and neurohormonal stress, and cardiac remodelling in heart failure – TORNADO: a study protocol for a randomized controlled trial Abstract Abstract Background Approximately 50% of heart failure patients are readmitted to hospital within 6 months, owing to deterioration of their c... |
PMC7801763 | core_pubmed_pmc | Role of Intestinal Microbiota in Metabolism of Voglibose In Vitro and In Vivo | Role of Intestinal Microbiota in Metabolism of Voglibose In Vitro and In Vivo Abstract Background Voglibose, an α-glucosidase inhibitor, inhibits breakdown of complex carbohydrates into simple sugar units in intestine. Studies showed that voglibose metabolism in the liver might be negligible due to its poor intestinal ... |
PMC12036670 | core_pubmed_pmc | Quantifying the Source–Receptor Relationships of P M 2 . 5 Pollution and Associated Health Impacts among China, South Korea, and Japan: A Dual Perspective and an Interdisciplinary Approach | Quantifying the Source–Receptor Relationships of P M 2 . 5 Pollution and Associated Health Impacts among China, South Korea, and Japan: A Dual Perspective and an Interdisciplinary Approach Abstract Background: Transboundary particulate matter (PM) with aerodynamic diameter ≤ 2.5 μ m ( PM 2.5 ) pollution is causing sign... |
PMC10694774 | core_pubmed_pmc | Pharmacodynamics, safety, tolerability and pharmacokinetics of a single oral dose of an engineered phenylalanine ammonia-lyase in patients with phenylketonuria | Pharmacodynamics, safety, tolerability and pharmacokinetics of a single oral dose of an engineered phenylalanine ammonia-lyase in patients with phenylketonuria Abstract The cornerstone treatment of hyperphenylalaninemia (HPA) and phenylketonuria (PKU) is a lifelong low-protein diet with phenylalanine (Phe) free L-amino... |
PMC10221142 | core_pubmed_pmc | Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide | Anti-Cancer Agent: The Labdane Diterpenoid-Andrographolide Abstract In spite of the progress in treatment strategies, cancer remains a major cause of death worldwide. Therefore, the main challenge should be the early diagnosis of cancer and the design of an optimal therapeutic strategy to increase the patient’s life ex... |
PMC10805209 | core_pubmed_pmc | Caffeine – Essentials for anaesthesiologists: A narrative review | Caffeine – Essentials for anaesthesiologists: A narrative review Abstract Abstract Caffeine has a multitude of uses in anaesthesia, and numerous studies have evaluated its efficacy and usefulness in various aspects of anaesthesia and medical practice. Its various applications in anaesthesia include its role in awakenin... |
PMC12539121 | core_pubmed_pmc | Expression of multidrug efflux pump gene acrAB in Escherichia coli : a systematic review and meta analysis | Expression of multidrug efflux pump gene acrAB in Escherichia coli : a systematic review and meta analysis Abstract Abstract Background Multidrug-resistant (MDR) Escherichia coli ( E.coli ) is a growing public health concern, largely driven by the overexpression of efflux pumps such as AcrAB-tolC . These efflux systems... |
PMC7036601 | core_pubmed_pmc | A Novel Drug Delivery Carrier Comprised of Nimodipine Drug Solution and a Nanoemulsion: Preparation, Characterization, in vitro, and in vivo Studies | A Novel Drug Delivery Carrier Comprised of Nimodipine Drug Solution and a Nanoemulsion: Preparation, Characterization, in vitro, and in vivo Studies Abstract Purpose Nimodipine (NIMO) is used clinically to treat ischemic damage resulting from subarachnoid hemorrhage. However, clinical application of NIMO is limited by ... |
PMC7011339 | core_pubmed_pmc | Population pharmacokinetics of riociguat and its metabolite in patients with chronic thromboembolic pulmonary hypertension from routine clinical practice | Population pharmacokinetics of riociguat and its metabolite in patients with chronic thromboembolic pulmonary hypertension from routine clinical practice Abstract Abstract Pharmacokinetic data for riociguat in patients with chronic thromboembolic pulmonary hypertension (CTEPH) have previously been reported from randomi... |
PMC10903328 | core_pubmed_pmc | Bidirectional pharmacokinetics of doravirine, tenofovir, and feminizing hormones in transgender women (IDentify): A randomized crossover trial | Bidirectional pharmacokinetics of doravirine, tenofovir, and feminizing hormones in transgender women (IDentify): A randomized crossover trial Abstract Abstract Transgender women may have concerns of drug interactions between feminizing hormone therapy (FHT) and antiretrovirals, leading to nonadherence. This randomized... |
PMC7780030 | core_pubmed_pmc | Iron chelation cancer therapy using hydrophilic block copolymers conjugated with deferoxamine | Iron chelation cancer therapy using hydrophilic block copolymers conjugated with deferoxamine Abstract Abstract Cancer cells have high iron requirements due to their rapid growth and proliferation. Iron depletion using iron chelators has a potential in cancer treatment. Previous studies have demonstrated that deferoxam... |
PMC7571299 | core_pubmed_pmc | Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19 | Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19 Abstract The urgent need for a cure for early phase COVID-19 infected patients critically underlines drug repositioning strategies able to efficiently identify new and reliable treatments by merging computational, experimental, and pharmacok... |
PMC8246729 | core_pubmed_pmc | Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP 2C8 and OATP 1B Drug Substrates | Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP 2C8 and OATP 1B Drug Substrates Abstract Chronic kidney disease ( CKD ) differentially affects the pharmacokinetics ( PK ) of nonrenally cleared drugs via certain pathways (e.g., cyto... |
PMC4075152 | core_pubmed_pmc | Beta-lactam dosing in critically ill patients with septic shock and continuous renal replacement therapy | Beta-lactam dosing in critically ill patients with septic shock and continuous renal replacement therapy Abstract Although early and appropriate antibiotic therapy remains the most important intervention for successful treatment of septic shock, data guiding optimization of beta-lactam prescription in critically ill pa... |
PMC9168866 | core_pubmed_pmc | Improving the tolerability of osimertinib by identifying its toxic limit | Improving the tolerability of osimertinib by identifying its toxic limit Abstract Abstract Background: Osimertinib is the cornerstone in the treatment of epidermal growth factor receptor-mutated non-small cell lung cancer (NSCLC). Nonetheless, ±25% of patients experience severe treatment-related toxicities. Currently, ... |
PMC12041064 | core_pubmed_pmc | Opportunities for Precision Dosing of Cytotoxic Drugs in Non-Small Cell Lung Cancer: Bridging the Gap in Precision Medicine | Opportunities for Precision Dosing of Cytotoxic Drugs in Non-Small Cell Lung Cancer: Bridging the Gap in Precision Medicine Abstract Precision dosing of classical cytotoxic drugs in oncology remains underdeveloped, especially in treating non-small cell lung cancer (NSCLC). Despite advancements in targeted therapy and i... |
PMC8602931 | core_pubmed_pmc | Phase 2 study of danicopan in patients with paroxysmal nocturnal hemoglobinuria with an inadequate response to eculizumab | Phase 2 study of danicopan in patients with paroxysmal nocturnal hemoglobinuria with an inadequate response to eculizumab Abstract Key Points Danicopan, a first-in-class oral factor D inhibitor showed clinical benefit when given in addition to eculizumab in patients with PNH. Addition of danicopan reduced extravascular... |
PMC12246539 | core_pubmed_pmc | Phase I First-in-Human Study of TRK-950, an IgG1 Antibody Specific to CAPRIN-1, in Patients with Advanced Solid Tumors | Phase I First-in-Human Study of TRK-950, an IgG1 Antibody Specific to CAPRIN-1, in Patients with Advanced Solid Tumors Abstract Abstract Purpose: TRK-950 is a first-in-class humanized antibody targeting cytoplasmic activation/proliferation-associated protein-1, which is strongly expressed on the cell membrane surface i... |
PMC10673948 | core_pubmed_pmc | Population pharmacokinetic modeling and dosing simulation of avalglucosidase alfa for selecting alternative dosing regimen in pediatric patients with late-onset pompe disease | Population pharmacokinetic modeling and dosing simulation of avalglucosidase alfa for selecting alternative dosing regimen in pediatric patients with late-onset pompe disease Abstract Avalglucosidase alfa (AVAL) was approved in the United States (2021) for patients with late-onset Pompe disease (LOPD), aged ≥ 1 year. I... |
PMC10112185 | core_pubmed_pmc | Determining the Delamanid Pharmacokinetics/Pharmacodynamics Susceptibility Breakpoint Using Monte Carlo Experiments | Determining the Delamanid Pharmacokinetics/Pharmacodynamics Susceptibility Breakpoint Using Monte Carlo Experiments Abstract ABSTRACT Antimicrobial susceptibility testing, based on clinical breakpoints that incorporate pharmacokinetics/pharmacodynamics (PK/PD) and clinical outcomes, is becoming a new standard in guidin... |
PMC11311171 | core_pubmed_pmc | Influence of Age, Gender and Body Mass Index on Intravenous Pharmacokinetics of Buprenorphine in Children Undergoing Orthopedic Surgery | Influence of Age, Gender and Body Mass Index on Intravenous Pharmacokinetics of Buprenorphine in Children Undergoing Orthopedic Surgery Abstract Background Buprenorphine (BPN) is a widely used analgesic in the pediatric population, although there are few studies on the pharmacokinetics and pharmacodynamics of this drug... |
PMC9149647 | core_pubmed_pmc | Liquid Enteral Nutrients Alter the Pharmacokinetics of Orally Administered Carbamazepine in Rats | Liquid Enteral Nutrients Alter the Pharmacokinetics of Orally Administered Carbamazepine in Rats Abstract The interaction between enteral nutrients (ENs) and drugs co-administered through a nasogastric (NG) tube reportedly affects the absorption and resultant plasma concentrations of the respective drugs. However, the ... |
PMC9712479 | core_pubmed_pmc | Differences between men and women in response to antiseizure medication use and the likelihood of developing treatment resistant epilepsy | Differences between men and women in response to antiseizure medication use and the likelihood of developing treatment resistant epilepsy Abstract Abstract Objective The prevalence of epilepsy is slightly higher in women than in men and sensitivity to seizure stimuli differs between sexes. Some evidence suggests sex di... |
PMC8836276 | core_pubmed_pmc | Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids | Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids Abstract Doxorubicin is widely used in the treatment of different cancers, and its side effects can be severe in many tissues, including the intestines. Symptoms such as diarrhoea and abdominal pain caused by intestinal inflammation... |
PMC11018996 | core_pubmed_pmc | Pharmacokinetics of desflurane uptake and disposition in piglets | Pharmacokinetics of desflurane uptake and disposition in piglets Abstract Introduction: Many respiratory but few arterial blood pharmacokinetics of desflurane uptake and disposition have been investigated. We explored the pharmacokinetic parameters in piglets by comparing inspiratory, end-tidal, arterial blood, and mix... |
PMC12471540 | core_pubmed_pmc | Overview of Primary and Secondary Metabolites of Rugulopteryx okamurae Seaweed: Assessing Bioactivity, Scalability, and Molecular Mechanisms | Overview of Primary and Secondary Metabolites of Rugulopteryx okamurae Seaweed: Assessing Bioactivity, Scalability, and Molecular Mechanisms Abstract Abstract Rugulopteryx okamurae is an invasive brown alga that has colonised Mediterranean and northeastern Atlantic coastlines, posing significant ecological and economic... |
PMC6593727 | core_pubmed_pmc | A Cocktail Interaction Study Evaluating the Drug‐Drug Interaction Potential of the Perpetrator Drug ASP8477 at Multiple Ascending Dose Levels | A Cocktail Interaction Study Evaluating the Drug‐Drug Interaction Potential of the Perpetrator Drug ASP8477 at Multiple Ascending Dose Levels Abstract Abstract ASP8477 (molecular weight 325.36 g/mol) is a fatty acid amide hydrolase inhibitor intended for the treatment of neuropathic pain. Results from in vitro studies ... |
PMC6680613 | core_pubmed_pmc | In Vitro–In Vivo Correlations Based on In Vitro Dissolution of Parent Drug Diltiazem and Pharmacokinetics of Its Metabolite | In Vitro–In Vivo Correlations Based on In Vitro Dissolution of Parent Drug Diltiazem and Pharmacokinetics of Its Metabolite Abstract Abstract In this study a novel type of in vitro–in vivo correlation (IVIVC) is proposed: The correlation of the in vitro parent drug dissolution data with the in vivo pharmacokinetic data... |
PMC5395652 | core_pubmed_pmc | Input Estimation for Extended-Release Formulations Exemplified with Exenatide | Input Estimation for Extended-Release Formulations Exemplified with Exenatide Abstract Abstract Estimating the in vivo absorption profile of a drug is essential when developing extended-release medications. Such estimates can be obtained by measuring plasma concentrations over time and inferring the absorption from a m... |
PMC9684881 | core_pubmed_pmc | Comparison of Pharmacokinetic Similarity, Immunogenicity, and Safety of Ustekinumab and BAT2206 in Healthy Chinese Male Subjects in a Double-Blind, Randomized, Single-Dose, Parallel-Group Phase I Trial | Comparison of Pharmacokinetic Similarity, Immunogenicity, and Safety of Ustekinumab and BAT2206 in Healthy Chinese Male Subjects in a Double-Blind, Randomized, Single-Dose, Parallel-Group Phase I Trial Abstract Objective We aimed to evaluate the similarity of BAT2206 to its originator, ustekinumab, including pharmacoki... |
PMC10327353 | core_pubmed_pmc | Preclinical and clinical activity of DZD1516, a full blood–brain barrier-penetrant, highly selective HER2 inhibitor | Preclinical and clinical activity of DZD1516, a full blood–brain barrier-penetrant, highly selective HER2 inhibitor Abstract Background Patients with HER2-positive metastatic breast cancer (MBC) are at high risk of developing central nervous system (CNS) metastases. A potent and selective HER2 inhibitor with good blood... |
PMC11818818 | core_pubmed_pmc | Clinical and Biochemical Factors Associated with Infliximab Pharmacokinetics in Paediatric Patients with Inflammatory Bowel Disease | Clinical and Biochemical Factors Associated with Infliximab Pharmacokinetics in Paediatric Patients with Inflammatory Bowel Disease Abstract Abstract Monitoring infliximab (IFX) concentrations is crucial for optimizing IFX therapy in children with inflammatory bowel diseases (IBDs) who show low response rates due to in... |
PMC12555093 | core_pubmed_pmc | Evaluation of Characteristics and Ethnic Sensitivity for FDA‐Approved Drugs with Racial and Ethnic Differences in Pharmacokinetics, Safety, and Efficacy | Evaluation of Characteristics and Ethnic Sensitivity for FDA‐Approved Drugs with Racial and Ethnic Differences in Pharmacokinetics, Safety, and Efficacy Abstract Abstract Racial and ethnic differences in drug disposition and response may have a significant impact on its risk‐benefit balance. Therefore, it is important ... |
PMC12844797 | core_pubmed_pmc | Oral Bioavailability of Monoclonal Antibody | Oral Bioavailability of Monoclonal Antibody Abstract Abstract Background/Objectives: Despite significant interest in the oral delivery of antibodies, the oral bioavailability of monoclonal antibodies (mAbs) is not known to date. To find out an answer to this question, we have performed a preclinical investigation in mi... |
PMC8155022 | core_pubmed_pmc | Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534 | Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534 Abstract Abstract The nuclear receptor retinoid-related orphan receptor gamma t (RORγt) plays a critical role in driving Th17 cell differentiation and expansion, as well as IL-17 production in innate and adaptive immune cells. The IL-23/IL-17... |
PMC10535099 | core_pubmed_pmc | A Shortcut from Genome to Drug: The Employment of Bioinformatic Tools to Find New Targets for Gastric Cancer Treatment | A Shortcut from Genome to Drug: The Employment of Bioinformatic Tools to Find New Targets for Gastric Cancer Treatment Abstract Abstract Gastric cancer (GC) is a highly heterogeneous, complex disease and the fifth most common cancer worldwide (about 1 million cases and 784,000 deaths worldwide in 2018). GC has a poor p... |
PMC6161129 | core_pubmed_pmc | Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals | Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals Abstract Abstract Solid dosage forms of biopharmaceuticals such as therapeutic proteins could provide enhanced bioavailability, improved storage stability, as well as expanded alternatives to parenteral administration. Although numerous dry... |
PMC4471056 | core_pubmed_pmc | Predictive Performance of a Vancomycin Population Pharmacokinetic Model in Neonates | Predictive Performance of a Vancomycin Population Pharmacokinetic Model in Neonates Abstract Abstract Introduction The pharmacokinetics of vancomycin are highly variable among neonates, which makes dosing challenging in this population. However, adequate drug exposure is critical, especially when treating methicillin-r... |
PMC3787209 | core_pubmed_pmc | Multiple Imputation of Missing Covariates in NONMEM and Evaluation of the Method’s Sensitivity to η-Shrinkage | Multiple Imputation of Missing Covariates in NONMEM and Evaluation of the Method’s Sensitivity to η-Shrinkage Abstract Multiple imputation (MI) is an approach widely used in statistical analysis of incomplete data. However, its application to missing data problems in nonlinear mixed-effects modelling is limited. The ob... |
PMC12458472 | core_pubmed_pmc | Biodistribution-Driven Discovery Identifies a Glycosidase-Cleavable Linker to Reprogram Radiotheranostics | Biodistribution-Driven Discovery Identifies a Glycosidase-Cleavable Linker to Reprogram Radiotheranostics Abstract Abstract While radiopharmaceutical therapy (RPT) has become part of the standard-of-care for patients with advanced prostate cancers and neuroendocrine tumors (NETs), cures are elusive and normal tissue to... |
PMC8511381 | core_pubmed_pmc | Optimization of Linezolid Dosing Regimens for Treatment of Vancomycin-Resistant Enterococci Infection | Optimization of Linezolid Dosing Regimens for Treatment of Vancomycin-Resistant Enterococci Infection Abstract Abstract Background Linezolid, an oxazolidinone antibiotic, is recommended for vancomycin-resistant enterococci (VRE). However, 100% free-drug concentration above the minimum inhibitory concentration ( f T>MIC... |
PMC8711600 | core_pubmed_pmc | The Association Between Genetic Variants, Pharmacokinetics, and Infliximab Efficacy in Pediatric Patients With Crohn's Disease in China | The Association Between Genetic Variants, Pharmacokinetics, and Infliximab Efficacy in Pediatric Patients With Crohn's Disease in China Abstract Abstract Background: Infliximab is an effective therapy for Crohn's disease (CD). Early non-invasive predictors of disease remission allow for modification of treatments. The ... |
PMC9439974 | core_pubmed_pmc | Pharmacokinetic Evaluation of Intravenous Vitamin C: A Classic Pharmacokinetic Study | Pharmacokinetic Evaluation of Intravenous Vitamin C: A Classic Pharmacokinetic Study Abstract Purpose Intravenous vitamin C (IVC) is used in a variety of disorders with limited supporting pharmacokinetic data. Herein we report a pharmacokinetic study in healthy volunteers and cancer participants with IVC doses in the r... |
PMC3179593 | core_pubmed_pmc | Neuronal network pharmacodynamics of GABAergic modulation in the human cortex determined using pharmaco‐magnetoencephalography † | Neuronal network pharmacodynamics of GABAergic modulation in the human cortex determined using pharmaco‐magnetoencephalography † Abstract Abstract Neuronal network oscillations are a unifying phenomenon in neuroscience research, with comparable measurements across scales and species. Cortical oscillations are of centra... |
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