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PMC5177737 | core_pubmed_pmc | Data Analysis Protocol for the Development and Evaluation of Population Pharmacokinetic Models for Incorporation Into the Web-Accessible Population Pharmacokinetic Service - Hemophilia (WAPPS-Hemo) | Data Analysis Protocol for the Development and Evaluation of Population Pharmacokinetic Models for Incorporation Into the Web-Accessible Population Pharmacokinetic Service - Hemophilia (WAPPS-Hemo) Abstract Background Hemophilia is an inherited bleeding disorder caused by a deficiency in a specific clotting factor. Thi... |
PMC9314805 | core_pubmed_pmc | The clinical pharmacology and potential therapeutic applications of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) | The clinical pharmacology and potential therapeutic applications of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) Abstract Abstract 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) is a naturally occurring tryptamine that primarily acts as an agonist at the 5‐HT1A and 5‐HT2A receptors, whereby affinity for the 5‐HT1A subtyp... |
PMC12922076 | core_pubmed_pmc | Controversial Aspects in Sedative Techniques for Drug-Induced Sleep Endoscopy (DISE)—A Narrative Review | Controversial Aspects in Sedative Techniques for Drug-Induced Sleep Endoscopy (DISE)—A Narrative Review Abstract Background/Objectives: Drug-induced sleep endoscopy (DISE) is used in obstructive sleep apnea (OSA) to visualize dynamic upper airway collapse, but sedation protocols vary widely with no consensus on the opt... |
PMC10428082 | core_pubmed_pmc | Safety and Efficacy of Zavegepant in Treating Migraine: A Systematic Review | Safety and Efficacy of Zavegepant in Treating Migraine: A Systematic Review Abstract Abstract Drugs that act on the calcitonin gene-related peptide (CGRP) pathway herald the dawn of a new era in the management of migraine headaches. The blockade of CGRP alleviates neural inflammation and has been associated with reduce... |
PMC7808142 | core_pubmed_pmc | Oral Bioavailability Comparison of Artemisinin, Deoxyartemisinin, and 10-Deoxoartemisinin Based on Computer Simulations and Pharmacokinetics in Rats | Oral Bioavailability Comparison of Artemisinin, Deoxyartemisinin, and 10-Deoxoartemisinin Based on Computer Simulations and Pharmacokinetics in Rats Abstract Abstract Deoxyartemisinin, a compound separated from Artemisinin annua L., shows anti-inflammatory and antiulcer activities. 10-Deoxoartemisinin is a novel compou... |
PMC9947246 | core_pubmed_pmc | How to use COVID-19 antiviral drugs in patients with chronic kidney disease | How to use COVID-19 antiviral drugs in patients with chronic kidney disease Abstract Antiviral drugs such as Remdesivir (Veklury), Nirmatrelvir with Ritonavir (Paxlovid), Azvudine, and Molnupiravir (Lagevrio) can reduce the risk for severe and fatal Coronavirus Disease (COVID)-19. Although chronic kidney disease is a h... |
PMC11052794 | core_pubmed_pmc | Clinical Pharmacokinetics and Pharmacodynamics of Naloxone | Clinical Pharmacokinetics and Pharmacodynamics of Naloxone Abstract Naloxone is a World Health Organization (WHO)-listed essential medicine and is the first choice for treating the respiratory depression of opioids, also by lay-people witnessing an opioid overdose. Naloxone acts by competitive displacement of opioid ag... |
PMC7550466 | core_pubmed_pmc | Pharmacokinetic and Safety Evaluation of Various Oral Doses of a Novel 1:20 THC:CBD Cannabis Herbal Extract in Dogs | Pharmacokinetic and Safety Evaluation of Various Oral Doses of a Novel 1:20 THC:CBD Cannabis Herbal Extract in Dogs Abstract Objective: To determine the pharmacokinetics (PK) and safety of various oral doses of a Cannabis herbal extract (CHE) containing a 1:20 ratio of Δ9-tetrahydrocannabinol (THC):cannabidiol (CBD) in... |
PMC11465898 | core_pubmed_pmc | Implementing differentially pigmented skin models for predicting drug response variability across human ancestries | Implementing differentially pigmented skin models for predicting drug response variability across human ancestries Abstract Abstract Persistent racial disparities in health outcomes have catalyzed legislative reforms and heightened scientific focus recently. However, despite the well-documented properties of skin pigme... |
PMC8203221 | core_pubmed_pmc | Modeling and characterization of inter-individual variability in CD8 T cell responses in mice | Modeling and characterization of inter-individual variability in CD8 T cell responses in mice Abstract To develop vaccines it is mandatory yet challenging to account for inter-individual variability during immune responses. Even in laboratory mice, T cell responses of single individuals exhibit a high heterogeneity tha... |
PMC7947502 | core_pubmed_pmc | Effect of vancomycin loading dose on clinical outcome in critically ill patients with methicillin-resistant Staphylococcus aureus pneumonia | Effect of vancomycin loading dose on clinical outcome in critically ill patients with methicillin-resistant Staphylococcus aureus pneumonia Abstract Abstract Background Vancomycin is the treatment of choice for serious methicillin-resistant Staphylococcus aureus (MRSA) infections. Current guidelines recommend giving an... |
PMC9138586 | core_pubmed_pmc | The Metabolic Activation of Sofosbuvir Is Impaired in an Experimental Model of NAFLD | The Metabolic Activation of Sofosbuvir Is Impaired in an Experimental Model of NAFLD Abstract Simple Summary Steatosis is a disease of the liver characterized by the deposition of lipids in hepatocytes. Although the effect of steatosis on the metabolism of drugs has been investigated, the findings obtained so far are s... |
PMC8604881 | core_pubmed_pmc | Systemic exposure following intravitreal administration of therapeutic agents: an integrated pharmacokinetic approach. 2. THR-687 | Systemic exposure following intravitreal administration of therapeutic agents: an integrated pharmacokinetic approach. 2. THR-687 Abstract Intravitreal (IVT) injection remains the preferred administration route of pharmacological agents intended for the treatment of back of the eye diseases such as diabetic macular ede... |
PMC9010252 | core_pubmed_pmc | Pharmacokinetic equations versus Bayesian guided vancomycin monitoring: Pharmacokinetic model and model‐informed precision dosing trial simulations | Pharmacokinetic equations versus Bayesian guided vancomycin monitoring: Pharmacokinetic model and model‐informed precision dosing trial simulations Abstract Abstract The recently released revised vancomycin consensus guideline endorsed area under the concentration‐time curve (AUC) guided monitoring. Means to AUC‐guided... |
PMC8160640 | core_pubmed_pmc | Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects | Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects Abstract Abstract The aims of this study were: (1) to perform population pharmacokinetic analysis of cefaclor in healthy Korean subjects, and (2) to investigate possible effects of various covariates on pharmacokinetic parameters of cefaclor. Al... |
PMC12473830 | core_pubmed_pmc | A Mechanistic Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach Informed by In Vitro and Clinical Studies for Topical Administration of Adapalene Gels | A Mechanistic Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach Informed by In Vitro and Clinical Studies for Topical Administration of Adapalene Gels Abstract Abstract Background/Objectives: Adapalene is a synthetic retinoid used as a treatment for acne vulgaris. In this study, we attempted to ev... |
PMC7474385 | core_pubmed_pmc | Pharmacokinetics of Transdermal Flunixin Meglumine Following a Single Dose in Marine Toads ( Rhinella marina ) | Pharmacokinetics of Transdermal Flunixin Meglumine Following a Single Dose in Marine Toads ( Rhinella marina ) Abstract Abstract Transdermal administration is an important method of pharmacologic drug therapy in amphibians, made possible by their unique skin physiology and permeability. Despite this, there are relative... |
PMC11976153 | core_pubmed_pmc | Comparison of pharmacokinetics of a fixed-dose combination of atorvastatin/ezetimibe 5 mg/10 mg versus separate tablets in healthy subjects | Comparison of pharmacokinetics of a fixed-dose combination of atorvastatin/ezetimibe 5 mg/10 mg versus separate tablets in healthy subjects Abstract The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors are well-established treatment options for dyslipidemia. For patients not meeting low-density lipoprotein ch... |
PMC7679075 | core_pubmed_pmc | Drug‐Disease Interaction and Time‐Dependent Population Pharmacokinetics of Isatuximab in Relapsed/Refractory Multiple Myeloma Patients | Drug‐Disease Interaction and Time‐Dependent Population Pharmacokinetics of Isatuximab in Relapsed/Refractory Multiple Myeloma Patients Abstract Abstract Isatuximab, a monoclonal antibody (mAb) of immunoglobulin G (IgG) isotype, specifically targets the cluster of differentiation 38 antigen overexpressed in malignant pl... |
PMC12211842 | core_pubmed_pmc | Protocol for a multicentre, open-label, dose-escalation phase I/II study evaluating the tolerability, safety, efficacy and pharmacokinetics of repeated continuous intravenous PPMX-T003 in patients with aggressive natural killer cell leukaemia | Protocol for a multicentre, open-label, dose-escalation phase I/II study evaluating the tolerability, safety, efficacy and pharmacokinetics of repeated continuous intravenous PPMX-T003 in patients with aggressive natural killer cell leukaemia Abstract Abstract Introduction Aggressive natural killer cell leukaemia (ANKL... |
PMC3707008 | core_pubmed_pmc | Antibiotics for the critically ill: more than just selecting appropriate initial therapy | Antibiotics for the critically ill: more than just selecting appropriate initial therapy Abstract Abstract Critically ill patients with infection provide a number of challenges to clinicians in terms of optimizing their antimicrobial treatment. Of foremost importance, initial antibiotic treatment should be selected as ... |
PMC9456061 | core_pubmed_pmc | Ligand-Based Virtual Screening and Molecular Docking of Benzimidazoles as Potential Inhibitors of Triosephosphate Isomerase Identified New Trypanocidal Agents | Ligand-Based Virtual Screening and Molecular Docking of Benzimidazoles as Potential Inhibitors of Triosephosphate Isomerase Identified New Trypanocidal Agents Abstract Abstract Trypanosoma cruzi ( T. cruzi ) is a parasite that affects humans and other mammals. T. cruzi depends on glycolysis as a source of adenosine tri... |
PMC7306033 | core_pubmed_pmc | Aqueous humour concentrations after topical apPlication of combinEd levofloxacin-dexamethasone eye dRops and of its single components: a randoMised, assEssor-blinded, parallel-group study in patients undergoing cataract surgery: the iPERME study | Aqueous humour concentrations after topical apPlication of combinEd levofloxacin-dexamethasone eye dRops and of its single components: a randoMised, assEssor-blinded, parallel-group study in patients undergoing cataract surgery: the iPERME study Abstract Abstract Purpose To evaluate the penetration of levofloxacin and ... |
PMC9914098 | core_pubmed_pmc | Lurasidone for the treatment of schizophrenia in adult and paediatric populations | Lurasidone for the treatment of schizophrenia in adult and paediatric populations Abstract Abstract Schizophrenia is a common debilitating disorder characterized by significant impairments in how reality is perceived, combined with behavioural changes. In this review, we describe the lurasidone development programme fo... |
PMC9413514 | core_pubmed_pmc | Accessing Lipophilicity and Biomimetic Chromatography Profile of Biologically Active Ingredients of Botanicals Used in the Treatment of Inflammatory Bowel Disease | Accessing Lipophilicity and Biomimetic Chromatography Profile of Biologically Active Ingredients of Botanicals Used in the Treatment of Inflammatory Bowel Disease Abstract Abstract In the present study, various procedures have been compared for the determination of lipophilicity, hydrophobicity, and plasma protein bind... |
PMC9230881 | core_pubmed_pmc | Co-Amorphous Formation of Simvastatin-Ezetimibe: Enhanced Physical Stability, Bioavailability and Cholesterol-Lowering Effects in LDLr−/−Mice | Co-Amorphous Formation of Simvastatin-Ezetimibe: Enhanced Physical Stability, Bioavailability and Cholesterol-Lowering Effects in LDLr−/−Mice Abstract Abstract Hypercholesterolemia is one of the independent risk factors for the development of cardiovascular diseases such as atherosclerosis. The treatment of hypercholes... |
PMC12740544 | core_pubmed_pmc | Accuracy and precision of few‐time‐points renal dosimetry for [ 177 Lu]Lu‐PSMA‐617 therapy: Analysis with nonlinear mixed‐effects modeling | Accuracy and precision of few‐time‐points renal dosimetry for [ 177 Lu]Lu‐PSMA‐617 therapy: Analysis with nonlinear mixed‐effects modeling Abstract Abstract Background Determination of time‐integrated activity (TIA) with a reduced number of imaging sessions is essential for minimizing patient burden and clinical worklo... |
PMC5987897 | core_pubmed_pmc | Pharmacotherapy of Insomnia | Pharmacotherapy of Insomnia Abstract Abstract Insomnia remains a common clinical concern that is associated with negative daytime consequences for patients and represents a significant public health problem for our society. Although a variety of therapies may be employed to treat insomnia, the use of medications has be... |
PMC8902680 | core_pubmed_pmc | Oleandrin: A Systematic Review of its Natural Sources, Structural Properties, Detection Methods, Pharmacokinetics and Toxicology | Oleandrin: A Systematic Review of its Natural Sources, Structural Properties, Detection Methods, Pharmacokinetics and Toxicology Abstract Abstract Oleandrin is a highly lipid-soluble cardiac glycoside isolated from the plant Nerium oleander (Apocynaceae) and is used as a traditional herbal medicine due to its excellent... |
PMC7297445 | core_pubmed_pmc | Pharmacokinetic/Pharmacodynamic Determination and Preclinical Pharmacokinetics of the β-Lactamase Inhibitor ETX1317 and Its Orally Available Prodrug ETX0282 | Pharmacokinetic/Pharmacodynamic Determination and Preclinical Pharmacokinetics of the β-Lactamase Inhibitor ETX1317 and Its Orally Available Prodrug ETX0282 Abstract Increasingly resistant Enterobacteriaceae have emerged as a health threat in both hospital and community settings. Infections of the urinary tract, once o... |
PMC10535515 | core_pubmed_pmc | The First Physiologically Based Pharmacokinetic (PBPK) Model for an Oral Vaccine Using Alpha-Tocopherol as an Adjuvant | The First Physiologically Based Pharmacokinetic (PBPK) Model for an Oral Vaccine Using Alpha-Tocopherol as an Adjuvant Abstract Oral vaccines represent many advantages compared to standard vaccines. They hold a simple method of administration and manufacturing process. In addition to these, the way they can induce immu... |
PMC8894812 | core_pubmed_pmc | Pharmacogenetics and Precision Medicine Approaches for the Improvement of COVID-19 Therapies | Pharmacogenetics and Precision Medicine Approaches for the Improvement of COVID-19 Therapies Abstract Many drugs are being administered to tackle coronavirus disease 2019 (COVID-19) pandemic situations without establishing clinical effectiveness or tailoring safety. A repurposing strategy might be more effective and su... |
PMC9258952 | core_pubmed_pmc | Transplanted organoids empower human preclinical assessment of drug candidate for the clinic | Transplanted organoids empower human preclinical assessment of drug candidate for the clinic Abstract Pharmacodynamic (PD) studies are an essential component of preclinical drug discovery. Current approaches for PD studies, including the analysis of novel kidney disease targeting therapeutic agents, are limited to anim... |
PMC8241901 | core_pubmed_pmc | Therapeutic Drug Monitoring of Tigecycline in 67 Infected Patients and a Population Pharmacokinetics/Microbiological Evaluation of A. baumannii Study | Therapeutic Drug Monitoring of Tigecycline in 67 Infected Patients and a Population Pharmacokinetics/Microbiological Evaluation of A. baumannii Study Abstract Abstract Background The widespread use of antibiotics has led to the emergence of multidrug-resistant (MDR) bacteria such as multidrug-resistant Acinetobacter ba... |
PMC9543581 | core_pubmed_pmc | Predictive performance of pharmacokinetic models for target concentration‐controlled infusion of cefoxitin as a prophylactic antibiotic in patients with colorectal surgery | Predictive performance of pharmacokinetic models for target concentration‐controlled infusion of cefoxitin as a prophylactic antibiotic in patients with colorectal surgery Abstract Abstract We aimed to evaluate the predictive performance of previously constructed free (C free ) and total (C total ) cefoxitin pharmacoki... |
PMC10077752 | core_pubmed_pmc | Insights on the in-vitro binding interaction between donepezil and bovine serum albumin | Insights on the in-vitro binding interaction between donepezil and bovine serum albumin Abstract Abstract In this work, the binding mechanism between donepezil (DNP) and bovine serum albumin (BSA) was established using several techniques, including fluorimetry, UV- spectrophotometry, synchronous fluorimetry (SF), fouri... |
PMC12655107 | core_pubmed_pmc | Development and Pharmacokinetic Evaluation of Newly Formulated Letrozole Non-Aqueous Nanoemulgel Transdermal Systems for Hormone-Dependent Breast Cancer Therapy | Development and Pharmacokinetic Evaluation of Newly Formulated Letrozole Non-Aqueous Nanoemulgel Transdermal Systems for Hormone-Dependent Breast Cancer Therapy Abstract Abstract Background/Objectives: Breast cancer remains the most prevalent malignancy among women worldwide, with letrozole (LZ) serving as a critical a... |
PMC9864617 | core_pubmed_pmc | Corydalis saxicola Bunting: A Review of Its Traditional Uses, Phytochemistry, Pharmacology, and Clinical Applications | Corydalis saxicola Bunting: A Review of Its Traditional Uses, Phytochemistry, Pharmacology, and Clinical Applications Abstract Corydalis saxicola Bunting (CSB), whose common name in Chinese is Yanhuanglian, is a herb in the family Papaveraceae. When applied in traditional Chinese medicine, it is used to treat various d... |
PMC7935823 | core_pubmed_pmc | Population Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukemia: Treatment Phase Dependency and Predictivity in Case of Missing Data | Population Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukemia: Treatment Phase Dependency and Predictivity in Case of Missing Data Abstract Background and Objectives The pharmacokinetics of polyethylene glycol-conjugated asparaginase (PEG-ASNase) are characterized by an increase in... |
PMC10221334 | core_pubmed_pmc | An In Silico Approach toward the Appropriate Absorption Rate Metric in Bioequivalence | An In Silico Approach toward the Appropriate Absorption Rate Metric in Bioequivalence Abstract Abstract In bioequivalence, the maximum plasma concentration (Cmax) is traditionally used as a metric for the absorption rate, despite the fact that there are several concerns. The idea of “average slope” (AS) was recently in... |
PMC12821266 | core_pubmed_pmc | Associations between rivaroxaban dose, gut microbiota, and coagulation parameters in a rat model | Associations between rivaroxaban dose, gut microbiota, and coagulation parameters in a rat model Abstract Abstract Rivaroxaban, a direct oral anticoagulant, is widely prescribed for thrombotic disorders, yet growing evidence suggests that gut microbiota may influence its pharmacodynamic effects. This study investigated... |
PMC8395583 | core_pubmed_pmc | Broadly Neutralizing Synthetic Cannabinoid Vaccines | Broadly Neutralizing Synthetic Cannabinoid Vaccines Abstract Abstract Synthetic cannabinoids (SCs) constitute a significant portion of psychoactive substances forming a major public health risk. Due to the wide variety of SCs, broadly neutralizing antibodies generated by active immunization present an intriguing pathwa... |
PMC12823307 | core_pubmed_pmc | Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges | Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges Abstract ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden ... |
PMC6930854 | core_pubmed_pmc | Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII | Bayesian Forecasting Utilizing Bleeding Information to Support Dose Individualization of Factor VIII Abstract Abstract Bayesian forecasting for dose individualization of prophylactic factor VIII replacement therapy using pharmacokinetic samples is challenged by large interindividual variability in the bleeding risk. A ... |
PMC3846722 | core_pubmed_pmc | Rates of Fetal Polydrug Exposures in Methadone-Maintained Pregnancies from a High-Risk Population | Rates of Fetal Polydrug Exposures in Methadone-Maintained Pregnancies from a High-Risk Population Abstract Methadone maintenance treatment (MMT) is the standard of care during pregnancy for opioid-dependency, showing efficacy in improving prenatal care and reducing risk of relapse. By design, however, MMT is only inten... |
PMC6890621 | core_pubmed_pmc | The Selective Oral Immunomodulator Vidofludimus in Patients with Active Rheumatoid Arthritis: Safety Results from the COMPONENT Study | The Selective Oral Immunomodulator Vidofludimus in Patients with Active Rheumatoid Arthritis: Safety Results from the COMPONENT Study Abstract Introduction The dihydroorotate dehydrogenase (DHODH) inhibitors leflunomide and teriflunomide are immunomodulatory agents approved to treat rheumatoid arthritis (RA) and multip... |
PMC4241030 | core_pubmed_pmc | Pharmacokinetics of renally excreted drug dexpramipexole in subjects with impaired renal function | Pharmacokinetics of renally excreted drug dexpramipexole in subjects with impaired renal function Abstract Abstract This phase I, open-label, single-dose study evaluated the pharmacokinetics, safety, and tolerability of renally excreted drug dexpramipexole in subjects with normal and impaired renal function, i.e. mild,... |
PMC12367965 | core_pubmed_pmc | Exploring the influence of vaping on the pharmacokinetic fate of inhaled therapeutics | Exploring the influence of vaping on the pharmacokinetic fate of inhaled therapeutics Abstract Abstract The surge of electronic cigarette use in Australia, especially amongst the younger population, raises significant concerns about its impact on respiratory health. This review focuses on the detrimental effects of vap... |
PMC11164859 | core_pubmed_pmc | Investigating clinical pharmacokinetics of brivaracetam by using a pharmacokinetic modeling approach | Investigating clinical pharmacokinetics of brivaracetam by using a pharmacokinetic modeling approach Abstract Abstract The development of technology and the processing speed of computing machines have facilitated the evaluation of advanced pharmacokinetic (PK) models, making modeling processes simple and faster. The pr... |
PMC5811773 | core_pubmed_pmc | Two Phase 1, Open‐Label, Mass Balance Studies to Determine the Pharmacokinetics of 14 C‐Labeled Isavuconazonium Sulfate in Healthy Male Volunteers | Two Phase 1, Open‐Label, Mass Balance Studies to Determine the Pharmacokinetics of 14 C‐Labeled Isavuconazonium Sulfate in Healthy Male Volunteers Abstract Abstract Isavuconazonium sulfate is the water‐soluble prodrug of the active triazole isavuconazole. Two phase 1 studies were conducted to identify the metabolic pro... |
PMC4290702 | core_pubmed_pmc | Endothelin@25 – new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12 | Endothelin@25 – new agonists, antagonists, inhibitors and emerging research frontiers: IUPHAR Review 12 Abstract Abstract Since the discovery of endothelin (ET)-1 in 1988, the main components of the signalling pathway have become established, comprising three structurally similar endogenous 21-amino acid peptides, ET-1... |
PMC12049359 | core_pubmed_pmc | Ocular drug delivery systems based on nanotechnology: a comprehensive review for the treatment of eye diseases | Ocular drug delivery systems based on nanotechnology: a comprehensive review for the treatment of eye diseases Abstract Ocular drug delivery is a significant challenge due to the intricate anatomy of the eye and the various physiological barriers. Conventional therapeutic approaches, while effective to some extent, oft... |
PMC12864257 | core_pubmed_pmc | Extrapolating Guselkumab Efficacy to Juvenile Psoriatic Arthritis from Adult Psoriatic Arthritis and Adult and Pediatric Psoriasis Data | Extrapolating Guselkumab Efficacy to Juvenile Psoriatic Arthritis from Adult Psoriatic Arthritis and Adult and Pediatric Psoriasis Data Abstract Abstract Background Psoriatic arthritis (PsA) and juvenile PsA (jPsA) are chronic inflammatory diseases with similar features that differ by age and sequence of symptom onset.... |
PMC5458178 | core_pubmed_pmc | Catan-ionic hybrid lipidic nano-carriers for enhanced bioavailability and anti-tumor efficacy of chemodrugs | Catan-ionic hybrid lipidic nano-carriers for enhanced bioavailability and anti-tumor efficacy of chemodrugs Abstract Abstract To date there has not been any report on catan-ionic hybrid lipidic nano-carriers, let alone a report on applying them to deliver insoluble anti-tumor drugs. Catan-ionic hybrid lipidic nano-carr... |
PMC12472829 | core_pubmed_pmc | Fluazuron Baits in the Control of Amblyomma sculptum Tick: Efficacy and Pharmacokinetics Using Guinea Pigs as an Experimental Model | Fluazuron Baits in the Control of Amblyomma sculptum Tick: Efficacy and Pharmacokinetics Using Guinea Pigs as an Experimental Model Abstract The tick Amblyomma sculptum is the vector of the bacterium Rickettsia rickettsii (which causes Brazilian Spotted Fever in humans). It can be found in domestic and wild animals, as... |
PMC8295170 | core_pubmed_pmc | Efficacy, Safety and Immunogenicity of MB02 (Bevacizumab Biosimilar) versus Reference Bevacizumab in Advanced Non-Small Cell Lung Cancer: A Randomized, Double-Blind, Phase III Study (STELLA) | Efficacy, Safety and Immunogenicity of MB02 (Bevacizumab Biosimilar) versus Reference Bevacizumab in Advanced Non-Small Cell Lung Cancer: A Randomized, Double-Blind, Phase III Study (STELLA) Abstract Background MB02 (bevacizumab biosimilar) showed similar structural, functional, and pharmacokinetic properties to refere... |
PMC4918890 | core_pubmed_pmc | Neuromuscular blockade in the elderly patient | Neuromuscular blockade in the elderly patient Abstract Neuromuscular blockade is a desirable or even essential component of general anesthesia for major surgical operations. As the population continues to age, and more operations are conducted in the elderly, due consideration must be given to neuromuscular blockade in... |
PMC7699454 | core_pubmed_pmc | PLGA Nanoparticle Platform for Trans-Ocular Barrier to Enhance Drug Delivery: A Comparative Study Based on the Application of Oligosaccharides in the Outer Membrane of Carriers | PLGA Nanoparticle Platform for Trans-Ocular Barrier to Enhance Drug Delivery: A Comparative Study Based on the Application of Oligosaccharides in the Outer Membrane of Carriers Abstract Abstract Purpose The trans-ocular barrier is a key factor limiting the therapeutic efficacy of triamcinolone acetonide. We developed a... |
PMC12845130 | core_pubmed_pmc | Translational Model to Predict Lung and Prostate Distribution of Levofloxacin in Humans | Translational Model to Predict Lung and Prostate Distribution of Levofloxacin in Humans Abstract Abstract Background/Objectives: Levofloxacin (LVX) is a fluoroquinolone approved for the treatment of bacterial pneumonia, sinusitis, and prostatitis. Emerging in vitro and preclinical evidence suggests that efflux transpor... |
PMC7053291 | core_pubmed_pmc | Development of a RP-HPLC method for analysis of docetaxel in tumor-bearing mice plasma and tissues following injection of docetaxel-loaded pH responsive targeting polymeric micelles | Development of a RP-HPLC method for analysis of docetaxel in tumor-bearing mice plasma and tissues following injection of docetaxel-loaded pH responsive targeting polymeric micelles Abstract Abstract Background and purpose: A simple, rapid, and sensitive reversed-phase high performance liquid chromatography (RP-HPLC) m... |
PMC3583942 | core_pubmed_pmc | Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors | Phase I study of the CD40 agonist antibody CP-870,893 combined with carboplatin and paclitaxel in patients with advanced solid tumors Abstract Abstract CD40 is a cell-surface molecule that critically regulates immune responses. CP-870,893 is a fully human, CD40-specific agonist monoclonal antibody (mAb) exerting clinic... |
PMC5215255 | core_pubmed_pmc | Time-Dependent Structural Alteration of Rituximab Analyzed by LC/TOF-MS after a Systemic Administration to Rats | Time-Dependent Structural Alteration of Rituximab Analyzed by LC/TOF-MS after a Systemic Administration to Rats Abstract Abstract Therapeutic monoclonal antibodies (mAbs) have heterogeneities in their structures. Multiple studies have reported that the variety of post-translational modifications could affect the pharma... |
PMC10792855 | core_pubmed_pmc | Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells | Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells Abstract Background Intestinal epithelial cells derived from human pluripotent stem cells (hPSCs) are generally maintained and cultured as organoids in vitro because they do not exhibit ad... |
PMC11670700 | core_pubmed_pmc | A phase I dose-escalation study of LRP5/6 antagonist BI 905677 in patients with advanced solid tumors | A phase I dose-escalation study of LRP5/6 antagonist BI 905677 in patients with advanced solid tumors Abstract Background Aberrant Wnt pathway signaling has been implicated in the development of many cancers. Targeting of low-density lipoprotein receptor-related protein 5/6 (LRP5/6) co-receptors inhibits Wnt signaling ... |
PMC6560803 | core_pubmed_pmc | Potential drug–drug interactions and associated factors among hospitalized cardiac patients at Jimma University Medical Center, Southwest Ethiopia | Potential drug–drug interactions and associated factors among hospitalized cardiac patients at Jimma University Medical Center, Southwest Ethiopia Abstract Background: Concomitant use of several drugs for a patient is often imposing increased risk of drug–drug interactions. Drug–drug interactions are a major cause for ... |
PMC8158482 | core_pubmed_pmc | Development and In Vitro Evaluation of Controlled Release Viagra ® Containing Poloxamer-188 Using Gastroplus ™ PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments | Development and In Vitro Evaluation of Controlled Release Viagra ® Containing Poloxamer-188 Using Gastroplus ™ PBPK Modeling Software for In Vivo Predictions and Pharmacokinetic Assessments Abstract Sildenafil is the active substance in Viagra ® tablets, which is approved by the FDA to treat sexual dysfunction in men. ... |
PMC12755061 | core_pubmed_pmc | Population Pharmacokinetics to Support Intravenous and Enteral Methadone Dosing in Children | Population Pharmacokinetics to Support Intravenous and Enteral Methadone Dosing in Children Abstract Abstract Methadone is used in hospitalized children to treat pain and iatrogenic opiate withdrawal. Optimal pediatric dosing for both enteral and intravenous methadone is unknown. We conducted two prospective, multi‐cen... |
PMC5584518 | core_pubmed_pmc | Population pharmacokinetics of fludarabine in patients with aplastic anemia and Fanconi anemia undergoing allogeneic hematopoietic stem cell transplantation | Population pharmacokinetics of fludarabine in patients with aplastic anemia and Fanconi anemia undergoing allogeneic hematopoietic stem cell transplantation Abstract Abstract Although hematopoietic stem cell transplantation (HSCT) with a conditioning regimen consisting of fludarabine (F-araA) and cyclophosphamide (Cy) ... |
PMC9487543 | core_pubmed_pmc | Safety and Pharmacokinetics of Taniborbactam (VNRX-5133) with Cefepime in Subjects with Various Degrees of Renal Impairment | Safety and Pharmacokinetics of Taniborbactam (VNRX-5133) with Cefepime in Subjects with Various Degrees of Renal Impairment Abstract ABSTRACT Taniborbactam, an investigational β-lactamase inhibitor that is active against both serine- and metallo-β-lactamases, is being developed in combination with cefepime to treat ser... |
PMC10088083 | core_pubmed_pmc | Population model‐based analysis of the memory B‐cell response following belimumab therapy in the treatment of systemic lupus erythematosus | Population model‐based analysis of the memory B‐cell response following belimumab therapy in the treatment of systemic lupus erythematosus Abstract Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B‐cell hyperactivity and breach of tolerance. Autoreactive memory B cells, which have ... |
PMC8042970 | core_pubmed_pmc | A phase 1 study of dalpiciclib, a cyclin-dependent kinase 4/6 inhibitor in Chinese patients with advanced breast cancer | A phase 1 study of dalpiciclib, a cyclin-dependent kinase 4/6 inhibitor in Chinese patients with advanced breast cancer Abstract Abstract Background Dalpiciclib (SHR6390) is a novel inhibitor of cyclin-dependent kinase 4/6 which demonstrated promising anti-tumor potency in preclinical models. This first-in-human study ... |
PMC12510396 | core_pubmed_pmc | Computational Fluid Dynamics Modeling of Intravitreal Ranibizumab Bolus Versus Subretinal ABBV-RGX-314 Transgene Product in Human Eyes | Computational Fluid Dynamics Modeling of Intravitreal Ranibizumab Bolus Versus Subretinal ABBV-RGX-314 Transgene Product in Human Eyes Abstract Purpose ABBV-RGX-314 is being developed for neovascular age-related macular degeneration (nAMD). Computational fluid dynamics (CFDs) modeling in the eye enables simulation of d... |
PMC5498608 | core_pubmed_pmc | UPLC-ESI-MS/MS and HPTLC Method for Quantitative Estimation of Cytotoxic Glycosides and Aglycone in Bioactivity Guided Fractions of Solanum nigrum L. | UPLC-ESI-MS/MS and HPTLC Method for Quantitative Estimation of Cytotoxic Glycosides and Aglycone in Bioactivity Guided Fractions of Solanum nigrum L. Abstract Solanum nigrum L., is traditionally used for the management of the various liver disorders. Investigating the effect of polarity based fractionation of S. nigrum... |
PMC12497703 | core_pubmed_pmc | Tyrosine-kinase inhibitors for lung or breast cancer and drug–drug interactions: a clinical guide | Tyrosine-kinase inhibitors for lung or breast cancer and drug–drug interactions: a clinical guide Abstract Abstract Introduction In the last two decades, tyrosine-kinase inhibitors (TKIs) have dramatically changed the prognosis of lung and breast cancers, with significant benefits in the metastatic setting and, more re... |
PMC7689911 | core_pubmed_pmc | Population Pharmacokinetics of Brentuximab Vedotin in Adult and Pediatric Patients With Relapsed/Refractory Hematologic Malignancies: Model‐Informed Hypothesis Generation for Pediatric Dosing Regimens | Population Pharmacokinetics of Brentuximab Vedotin in Adult and Pediatric Patients With Relapsed/Refractory Hematologic Malignancies: Model‐Informed Hypothesis Generation for Pediatric Dosing Regimens Abstract Abstract Prior pharmacokinetic (PK) analyses of the antibody‐drug conjugate (ADC) brentuximab vedotin (1.8 mg/... |
PMC5518218 | core_pubmed_pmc | Influence of Meals and Glycemic Changes on QT Interval Dynamics | Influence of Meals and Glycemic Changes on QT Interval Dynamics Abstract Abstract Thorough QT/QTc studies have become an integral part of early drug development programs, with major clinical and regulatory implications. This analysis expands on existing pharmacodynamic models of QT interval analysis by incorporating th... |
PMC12321875 | core_pubmed_pmc | Vancomycin levels for Bayesian dose-optimization in critical care: a prospective cohort study | Vancomycin levels for Bayesian dose-optimization in critical care: a prospective cohort study Abstract Abstract Background Vancomycin dosing in critically ill patients typically requires monitoring the area under the concentration-time curve/minimum inhibitory concentration (AUC/MIC), often using at least two vancomyci... |
PMC11531792 | core_pubmed_pmc | Comparing Two Vancomycin Loading Dose Regimens in Patients With Obesity: A Single-Center Prospective Clinical Trial | Comparing Two Vancomycin Loading Dose Regimens in Patients With Obesity: A Single-Center Prospective Clinical Trial Abstract Abstract Background: Obesity can significantly influence the pharmacokinetics of several medications, including vancomycin. Consequently, specialized dosing strategies may be required to ensure e... |
PMC7019112 | core_pubmed_pmc | Impact of Population and Pharmacogenetics Variations on Efavirenz Pharmacokinetics and Immunologic Outcomes During Anti-Tuberculosis Co-Therapy: A Parallel Prospective Cohort Study in Two Sub-Sahara African Populations | Impact of Population and Pharmacogenetics Variations on Efavirenz Pharmacokinetics and Immunologic Outcomes During Anti-Tuberculosis Co-Therapy: A Parallel Prospective Cohort Study in Two Sub-Sahara African Populations Abstract Efavirenz-based combination antiretroviral-therapy (cART) is the recommended regimen during ... |
PMC6000981 | core_pubmed_pmc | A cost effective RFLP method to genotype Solute carrier organic anion 1B1 ( SLCO1B1) c.1929A>C (p.Leu643Phe, rs34671512); a variant with potential effect on rosuvastatin pharmacokinetics | A cost effective RFLP method to genotype Solute carrier organic anion 1B1 ( SLCO1B1) c.1929A>C (p.Leu643Phe, rs34671512); a variant with potential effect on rosuvastatin pharmacokinetics Abstract Abstract Objective This study describes a restriction fragment polymorphism protocol for rapidly screening the polymorphism ... |
PMC12394376 | core_pubmed_pmc | Evaluation of the Effect of Ticagrelor Dose Interruption and Treatment Resumption with or without Bolus Doses Through Population PK/PD Simulation | Evaluation of the Effect of Ticagrelor Dose Interruption and Treatment Resumption with or without Bolus Doses Through Population PK/PD Simulation Abstract Abstract Background Ticagrelor is an oral P2Y 12 receptor antagonist used mostly in combination with aspirin, in patients with acute coronary syndromes (ACS). Ticagr... |
PMC8224782 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Modelling of Cabozantinib to Simulate Enterohepatic Recirculation, Drug–Drug Interaction with Rifampin and Liver Impairment | Physiologically Based Pharmacokinetic Modelling of Cabozantinib to Simulate Enterohepatic Recirculation, Drug–Drug Interaction with Rifampin and Liver Impairment Abstract Abstract Cabozantinib (CAB) is a receptor tyrosine kinase inhibitor approved for the treatment of several cancer types. Enterohepatic recirculation (... |
PMC7467405 | core_pubmed_pmc | Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Mini-Tabs Plus Ribavirin for Children Aged 3–11 Years with Hepatitis C Genotype 1a | Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Mini-Tabs Plus Ribavirin for Children Aged 3–11 Years with Hepatitis C Genotype 1a Abstract Abstract Introduction To assess the safety, efficacy, and pharmacokinetics of mini-tablet formulations of ombitasvir (OBV), paritaprevir (PTV), ritonavir, and dasabuvir (DSV) wi... |
PMC9818342 | core_pubmed_pmc | Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin | Pharmacodynamic Modeling to Evaluate the Impact of Cimetidine, an OCT2 Inhibitor, on the Anticancer Effects of Cisplatin Abstract Despite potent anticancer activity, the clinical utilization of cisplatin is limited due to nephrotoxicity. As Organic Cation Transporter 2 (OCT2) has been shown to be one of the key transpo... |
PMC7332755 | core_pubmed_pmc | Pharmacokinetics Alterations in Critically Ill Pediatric Patients on Extracorporeal Membrane Oxygenation: A Systematic Review | Pharmacokinetics Alterations in Critically Ill Pediatric Patients on Extracorporeal Membrane Oxygenation: A Systematic Review Abstract Abstract Objectives: This study aimed to identify alterations in pharmacokinetics in children on extracorporeal membrane oxygenation (ECMO), identify knowledge gaps, and inform future p... |
PMC10846240 | core_pubmed_pmc | Pharmacokinetic/pharmacodynamic integration of amphenmulin: a novel pleuromutilin derivative against Mycoplasma gallisepticum | Pharmacokinetic/pharmacodynamic integration of amphenmulin: a novel pleuromutilin derivative against Mycoplasma gallisepticum Abstract ABSTRACT Amphenmulin is a novel pleuromutilin derivative with great anti-mycoplasma potential. The present study evaluated the action characteristics of amphenmulin against Mycoplasma g... |
PMC11834215 | core_pubmed_pmc | Food effects and pharmacokinetic evaluation of oral single-dose prednisone acetate and prednisolone in healthy Chinese subjects | Food effects and pharmacokinetic evaluation of oral single-dose prednisone acetate and prednisolone in healthy Chinese subjects Abstract Background To assess the food effects and pharmacokinetic profile of oral prednisone (test preparation,5 mg) and prednisolone tablets (reference preparation,5 mg) using a randomized, ... |
PMC11773334 | core_pubmed_pmc | Preparation and pharmacokinetic evaluation of a sertraline-methylpropyphenazone prodrug: a comparative metabolic study on the plasma and brain tissues of rats using LC-MS/MS analysis † | Preparation and pharmacokinetic evaluation of a sertraline-methylpropyphenazone prodrug: a comparative metabolic study on the plasma and brain tissues of rats using LC-MS/MS analysis † Abstract A mutual prodrug of sertraline-methylpropyphenazone (SER-MP) was prepared and characterized using a spectral method. The yield... |
PMC11879349 | core_pubmed_pmc | Landiolol is effective and safe in paediatric supraventricular tachycardia: evidence from a European prospective multicentre open-label phase III study (LANDI-PED) | Landiolol is effective and safe in paediatric supraventricular tachycardia: evidence from a European prospective multicentre open-label phase III study (LANDI-PED) Abstract Abstract Aims Landiolol, an ultra-fast acting super-selective beta-blocker, was investigated for the first time in Europe in a prospective clinical... |
PMC9344961 | core_pubmed_pmc | Improving cellular uptake and bioavailability of periplocymarin-linoleic acid prodrug by combining PEGylated liposome | Improving cellular uptake and bioavailability of periplocymarin-linoleic acid prodrug by combining PEGylated liposome Abstract Abstract Periplocymarin (PPM), a cardiac glycoside isolated from Cortex periplocae , has a strong anti-tumor effect against various cancer cells. However, cardiotoxicity and rapid metabolism hi... |
PMC8212745 | core_pubmed_pmc | Asia‐inclusive global development of pevonedistat: Clinical pharmacology and translational research enabling a phase 3 multiregional clinical trial | Asia‐inclusive global development of pevonedistat: Clinical pharmacology and translational research enabling a phase 3 multiregional clinical trial Abstract Abstract The investigational NEDD8‐activating enzyme inhibitor pevonedistat is being evaluated in combination with azacitidine versus single‐agent azacitidine in p... |
PMC9707418 | core_pubmed_pmc | Gantenerumab: an anti-amyloid monoclonal antibody with potential disease-modifying effects in early Alzheimer’s disease | Gantenerumab: an anti-amyloid monoclonal antibody with potential disease-modifying effects in early Alzheimer’s disease Abstract Abstract Background This review describes the research and development process of gantenerumab, a fully human anti-amyloid monoclonal antibody in development to treat early symptomatic and as... |
PMC4734807 | core_pubmed_pmc | Liver-targeting Resibufogenin-loaded poly(lactic- co -glycolic acid)- d -α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for liver cancer therapy | Liver-targeting Resibufogenin-loaded poly(lactic- co -glycolic acid)- d -α-tocopheryl polyethylene glycol 1000 succinate nanoparticles for liver cancer therapy Abstract Liver cancer remains a major problem around the world. Resibufogenin (RBG) is a major bioactive compound that was isolated from Chansu (also called toa... |
PMC6364960 | core_pubmed_pmc | Adherence to intermittent preventive treatment for malaria in Papua New Guinean infants: A pharmacological study alongside the randomized controlled trial | Adherence to intermittent preventive treatment for malaria in Papua New Guinean infants: A pharmacological study alongside the randomized controlled trial Abstract Background The intermittent preventive treatment in infants (IPTi) trial that took place in Papua New Guinea showed an overall reduction of 29% of the risk ... |
PMC12421914 | core_pubmed_pmc | NFE2 and PF4 as biomarkers for BET inhibition-induced thrombocytopenia in preclinical and clinical studies | NFE2 and PF4 as biomarkers for BET inhibition-induced thrombocytopenia in preclinical and clinical studies Abstract Introduction Bromodomain and Extraterminal (BET) proteins play a crucial role in cellular proliferation and differentiation through the epigenetic regulation of gene transcription. As a result, inhibiting... |
PMC11550964 | core_pubmed_pmc | Patients with dementia: prevalence and type of drug–drug interactions | Patients with dementia: prevalence and type of drug–drug interactions Abstract Abstract Background Patients with Alzheimer’s disease (AD) and other dementias are more frequently exposed to polymedication, mainly due to the presence of comorbidities, are particularly vulnerable to drug-related problems, and present grea... |
PMC5019977 | core_pubmed_pmc | Evaluation of Pharmacodynamic Interactions Between Telavancin and Aztreonam or Piperacillin/Tazobactam Against Pseudomonas aeruginosa , Escherichia coli and Methicillin-Resistant Staphylococcus aureus | Evaluation of Pharmacodynamic Interactions Between Telavancin and Aztreonam or Piperacillin/Tazobactam Against Pseudomonas aeruginosa , Escherichia coli and Methicillin-Resistant Staphylococcus aureus Abstract Abstract Introduction In clinical trials comparing telavancin (TLV) with vancomycin for treatment of hospital-... |
PMC4134501 | core_pubmed_pmc | A phase IIa dose-finding and safety study of first-line pertuzumab in combination with trastuzumab, capecitabine and cisplatin in patients with HER2-positive advanced gastric cancer | A phase IIa dose-finding and safety study of first-line pertuzumab in combination with trastuzumab, capecitabine and cisplatin in patients with HER2-positive advanced gastric cancer Abstract Background: Pertuzumab plus trastuzumab provides a more comprehensive blockade of HER2 signalling than trastuzumab alone. Therefo... |
PMC3834884 | core_pubmed_pmc | A fully caninised anti-NGF monoclonal antibody for pain relief in dogs | A fully caninised anti-NGF monoclonal antibody for pain relief in dogs Abstract Abstract Background Monoclonal antibodies are a major class of biological therapies in human medicine but have not yet been successfully applied to veterinary species. We have developed a novel approach, PETisation, to rapidly convert antib... |
PMC12809411 | core_pubmed_pmc | Computational and experimental insights into the interaction of the seaweed-derived steroidal metabolite 11α-hydroxyprogesterone with the glucocorticoid receptor | Computational and experimental insights into the interaction of the seaweed-derived steroidal metabolite 11α-hydroxyprogesterone with the glucocorticoid receptor Abstract Abstract Seaweed-derived metabolites offer a rich source of bioactive compounds with therapeutic potential. In this study, 112 steroidal metabolites ... |
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