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PMC10614310 | core_pubmed_pmc | Pharmacokinetics and metabolism of lidocaine HCl 2% with epinephrine in horses following a palmar digital nerve block | Pharmacokinetics and metabolism of lidocaine HCl 2% with epinephrine in horses following a palmar digital nerve block Abstract Background Lidocaine is a local anesthetic that is sometimes administered in combination with epinephrine. The addition of epinephrine increases the time lidocaine remains at the site of admini... |
PMC9386913 | core_pubmed_pmc | CC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-inflammatory cytokine production | CC-99677, a novel, oral, selective covalent MK2 inhibitor, sustainably reduces pro-inflammatory cytokine production Abstract Background Mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) is activated downstream of p38 MAPK and regulates stability of mRNAs encoding inflammatory cytokines. CC-99677 ... |
PMC3102322 | core_pubmed_pmc | Pharmacokinetic-Pharmacodynamic Modeling of Metformin for the Treatment of Type II Diabetes Mellitus | Pharmacokinetic-Pharmacodynamic Modeling of Metformin for the Treatment of Type II Diabetes Mellitus Abstract Metformin is an antihyperglycemic agent commonly used for the treatment of Type II diabetes mellitus. However, its effects on patients are derived usually from clinical experiments. In this study, a dynamic mod... |
PMC10508544 | core_pubmed_pmc | Exposure‐safety and exposure‐efficacy analyses for tisotumab vedotin for patients with locally advanced or metastatic solid tumors | Exposure‐safety and exposure‐efficacy analyses for tisotumab vedotin for patients with locally advanced or metastatic solid tumors Abstract Abstract The antibody‐drug conjugate (ADC) tisotumab vedotin (TV) received accelerated approval from the US Food and Drug Administration for treatment of adults with recurrent or m... |
PMC10302406 | core_pubmed_pmc | Influence of Surface-Modification via PEGylation or Chitosanization of Lipidic Nanocarriers on In Vivo Pharmacokinetic/Pharmacodynamic Profiles of Apixaban | Influence of Surface-Modification via PEGylation or Chitosanization of Lipidic Nanocarriers on In Vivo Pharmacokinetic/Pharmacodynamic Profiles of Apixaban Abstract Abstract Nanostructured lipid carriers (NLCs) have been proven to significantly improve the bioavailability and efficacy of many drugs; however, they still... |
PMC12845259 | core_pubmed_pmc | Pharmacogenomics of CYP2D6, CYP2C19, CYP2C9, and Clinical Determinants of Fluoxetine–Norfluoxetine Pharmacokinetics in Real-World Clinical Conditions | Pharmacogenomics of CYP2D6, CYP2C19, CYP2C9, and Clinical Determinants of Fluoxetine–Norfluoxetine Pharmacokinetics in Real-World Clinical Conditions Abstract Abstract Background: Fluoxetine, a widely prescribed selective serotonin reuptake inhibitor, exhibits significant interindividual variability in pharmacokinetics... |
PMC8332596 | core_pubmed_pmc | Effects of Renal Impairment on the Pharmacokinetics of the Dual GIP and GLP-1 Receptor Agonist Tirzepatide | Effects of Renal Impairment on the Pharmacokinetics of the Dual GIP and GLP-1 Receptor Agonist Tirzepatide Abstract Abstract Background and Aims The pharmacokinetics (PK) and single-dose tolerability of tirzepatide, a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist being d... |
PMC11745869 | core_pubmed_pmc | Pharmacogenetic and pharmacokinetic factors for dexmedetomidine-associated hemodynamic instability in pediatric patients | Pharmacogenetic and pharmacokinetic factors for dexmedetomidine-associated hemodynamic instability in pediatric patients Abstract Purpose The incidence of hemodynamic instability associated with dexmedetomidine (DEX) sedation has been reported to exceed 50%, with substantial inter-individual variability in response. Ge... |
PMC5270291 | core_pubmed_pmc | Model‐Based Characterization of the Pharmacokinetics of Pembrolizumab: A Humanized Anti–PD‐1 Monoclonal Antibody in Advanced Solid Tumors | Model‐Based Characterization of the Pharmacokinetics of Pembrolizumab: A Humanized Anti–PD‐1 Monoclonal Antibody in Advanced Solid Tumors Abstract Abstract Pembrolizumab, a potent antibody against programmed death 1 (PD‐1) receptor, has shown robust antitumor activity and manageable safety in patients with advanced sol... |
PMC11091978 | core_pubmed_pmc | Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1 H -pyrazol-4-yl)({[(2 S )-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework | Pharmacological Analysis of NLRP3 Inflammasome Inhibitor Sodium [(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)carbamoyl][(1-methyl-1 H -pyrazol-4-yl)({[(2 S )-oxolan-2-yl]methyl})sulfamoyl]azanide in Cellular and Mouse Models of Inflammation Provides a Translational Framework Abstract Abstract Interleukin (IL)-1β is an apex p... |
PMC8437715 | core_pubmed_pmc | Borneol influences the pharmacokinetics of florfenicol through regulation of cytochrome P450 1A2 (CYP1A2), CYP2C11, CYP3A1, and multidrug resistance 1 (MDR1) mRNA expression levels in rats | Borneol influences the pharmacokinetics of florfenicol through regulation of cytochrome P450 1A2 (CYP1A2), CYP2C11, CYP3A1, and multidrug resistance 1 (MDR1) mRNA expression levels in rats Abstract Borneol is a traditional Chinese medicine. In Chinese veterinary clinics, borneol and its related compounds are often used... |
PMC7612567 | core_pubmed_pmc | Pharmacodynamic Biomarkers for Quantifying the Mycobacterial Effect of High Doses of Rifampin in Patients with Rifampin-susceptible Pulmonary Tuberculosis | Pharmacodynamic Biomarkers for Quantifying the Mycobacterial Effect of High Doses of Rifampin in Patients with Rifampin-susceptible Pulmonary Tuberculosis Abstract Background Suboptimal drug exposure in patients with drug-susceptible tuberculosis (DS-TB) can drive treatment failure. Pharmacodynamics (PD) biomarkers suc... |
PMC9053417 | core_pubmed_pmc | Guideline recommendations for antimicrobial stewardship education for clinical nursing practice in hospitals: A scoping review | Guideline recommendations for antimicrobial stewardship education for clinical nursing practice in hospitals: A scoping review Abstract Background Antimicrobial stewardship (AMS) is a proactive healthcare intervention to improve patient outcomes by optimising antimicrobial use. Although nursing involvement is a recogni... |
PMC11064479 | core_pubmed_pmc | Assessing potential drug-drug interactions between clofazimine and other frequently used agents to treat drug-resistant tuberculosis | Assessing potential drug-drug interactions between clofazimine and other frequently used agents to treat drug-resistant tuberculosis Abstract ABSTRACT Clofazimine is included in drug regimens to treat rifampicin/drug-resistant tuberculosis (DR-TB), but there is little information about its interaction with other drugs ... |
PMC5057500 | core_pubmed_pmc | Phase II study of TP300 in patients with advanced gastric or gastro-oesophageal junction adenocarcinoma | Phase II study of TP300 in patients with advanced gastric or gastro-oesophageal junction adenocarcinoma Abstract Background TP300, a recently developed synthetic camptothecin analogue, is a highly selective topoisomerase I inhibitor. A phase I study showed good safety and tolerability. As camptothecins have proven acti... |
PMC10975186 | core_pubmed_pmc | Modeling Pharmacokinetics in Individual Patients Using Therapeutic Drug Monitoring and Artificial Population Quasi-Models: A Study with Piperacillin | Modeling Pharmacokinetics in Individual Patients Using Therapeutic Drug Monitoring and Artificial Population Quasi-Models: A Study with Piperacillin Abstract Population pharmacokinetic (pop-PK) models constructed for model-informed precision dosing often have limited utility due to the low number of patients recruited.... |
PMC8920108 | core_pubmed_pmc | Lost in modelling and simulation? | Lost in modelling and simulation? Abstract Abstract Over the past few decades, physiologically-based pharmacokinetic modelling (PBPK) has been anticipated to be a powerful tool to improve the productivity of drug discovery and development. However, recently, multiple systematic evaluation studies independently suggeste... |
PMC9666522 | core_pubmed_pmc | Influence of tramadol on bacterial burden in the standard neutropenic thigh infection model | Influence of tramadol on bacterial burden in the standard neutropenic thigh infection model Abstract Abstract The neutropenic thigh infection model is one of the standard models in pharmacokinetic/ pharmacodynamic (PK/PD) characterization of novel antibacterials which are urgently needed due to the rise of antimicrobia... |
PMC12751989 | core_pubmed_pmc | A case report of wrist arthritis caused by Gemella haemolysans | A case report of wrist arthritis caused by Gemella haemolysans Abstract Abstract Background Septic wrist arthritis is rare and usually due to Staphylococcus aureus. Gemella haemolysans is exceptionally involved in osteoarticular infection, mainly reported in prosthetic infections or spondylodiscitis. Case presentation ... |
PMC8232873 | core_pubmed_pmc | Efficacy, Safety and Pharmacokinetic Results of a Phase III, Open-Label, Multicenter Study with a Plasma-Derived Von Willebrand Factor (VWF)/Factor VIII (FVIII) Concentrate in Pediatric Patients <12 Years of Age with Hemophilia A (SWIFTLY-HA Study) | Efficacy, Safety and Pharmacokinetic Results of a Phase III, Open-Label, Multicenter Study with a Plasma-Derived Von Willebrand Factor (VWF)/Factor VIII (FVIII) Concentrate in Pediatric Patients <12 Years of Age with Hemophilia A (SWIFTLY-HA Study) Abstract Abstract Background Plasma-derived von Willebrand factor/facto... |
PMC7579269 | core_pubmed_pmc | Tegaserod for the Treatment of Irritable Bowel Syndrome | Tegaserod for the Treatment of Irritable Bowel Syndrome Abstract Background: Tegaserod (Zelnorm®) is a 5-hydroxytryptamine (serotonin) type 4 receptor agonist for the treatment of hypomotility disorders of the lower gastrointestinal tract associated with the irritable bowel syndrome with constipation (IBS-C). Objective... |
PMC12347757 | core_pubmed_pmc | In Vitro Antimicrobial Activity of the Novel Antimicrobial Peptide OMN51 Against Multi-Drug-Resistant Pseudomonas aeruginosa Isolated from People with Cystic Fibrosis † | In Vitro Antimicrobial Activity of the Novel Antimicrobial Peptide OMN51 Against Multi-Drug-Resistant Pseudomonas aeruginosa Isolated from People with Cystic Fibrosis † Abstract Abstract Background: People with cystic fibrosis (pwCF) frequently suffer from chronic lung infections, with Pseudomonas aeruginosa being the ... |
PMC10745500 | core_pubmed_pmc | Engineering a New IFN-ApoA-I Fusion Protein with Low Toxicity and Prolonged Action | Engineering a New IFN-ApoA-I Fusion Protein with Low Toxicity and Prolonged Action Abstract Abstract Recombinant human interferon alpha-2b (rIFN) is widely used in antiviral and anticancer immunotherapy. However, the high efficiency of interferon therapy is accompanied by a number of side effects; this problem requires... |
PMC7427305 | core_pubmed_pmc | A phase I study of toripalimab, an anti‐PD‐1 antibody, in patients with refractory malignant solid tumors | A phase I study of toripalimab, an anti‐PD‐1 antibody, in patients with refractory malignant solid tumors Abstract Abstract Background Several programmed cell death ligand 1 (PD‐L1)/programmed cell death protein 1 (PD‐1) antibodies have been approved for cancer treatment worldwide. Their pharmacokinetic and pharmacodyn... |
PMC10380404 | core_pubmed_pmc | Glycosylation of Quercetin by Selected Entomopathogenic Filamentous Fungi and Prediction of Its Products’ Bioactivity | Glycosylation of Quercetin by Selected Entomopathogenic Filamentous Fungi and Prediction of Its Products’ Bioactivity Abstract Abstract Quercetin is the most abundant flavonoid in food products, including berries, apples, cauliflower, tea, cabbage, nuts, onions, red wine and fruit juices. It exhibits various biological... |
PMC6488552 | core_pubmed_pmc | Pharmacokinetic and Pharmacodynamic Properties of a Micro-Dose Nasal Spray Formulation of Desmopressin (AV002) in Healthy Water-Loaded Subjects | Pharmacokinetic and Pharmacodynamic Properties of a Micro-Dose Nasal Spray Formulation of Desmopressin (AV002) in Healthy Water-Loaded Subjects Abstract Abstract Purpose Antidiuretic therapy with desmopressin for nocturia has been hampered by formulations with high doses, low bioavailability and variable pharmacokineti... |
PMC5867575 | core_pubmed_pmc | Once Daily High Dose Tigecycline Is Optimal: Tigecycline PK/PD Parameters Predict Clinical Effectiveness | Once Daily High Dose Tigecycline Is Optimal: Tigecycline PK/PD Parameters Predict Clinical Effectiveness Abstract Abstract Objective: The clinical effectiveness of tigecycline depends on appropriate use, and PK/PD (pharmacokinetic/pharmacodynamic) parameters related to dose and dosing interval. Methods: In our 600-bed ... |
PMC9045047 | core_pubmed_pmc | Rationale and design of the CORE (COrticosteroids REvised) study: protocol | Rationale and design of the CORE (COrticosteroids REvised) study: protocol Abstract Abstract Introduction Corticosteroids are an important pillar in many anti-inflammatory and immunosuppressive treatment regimens and are available in natural and synthetic forms, which are considered equipotent if clinical bioequivalenc... |
PMC8595241 | core_pubmed_pmc | Methods to Develop an in silico Clinical Trial: Computational Head-to-Head Comparison of Lisdexamfetamine and Methylphenidate | Methods to Develop an in silico Clinical Trial: Computational Head-to-Head Comparison of Lisdexamfetamine and Methylphenidate Abstract Abstract Regulatory agencies encourage computer modeling and simulation to reduce the time and cost of clinical trials. Although still not classified in formal guidelines, system biolog... |
PMC7534356 | core_pubmed_pmc | Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review | Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review Abstract Abstract Context Acetylshikonin, a naphthoquinone derivative, is mainly extracted from some species of the family Boraginaceae, such as Lithospermum erythrorhizon Sieb. et Zucc., Arnebia euchroma (Royle) Johnst., and Arnebia guttata Bunge.... |
PMC2819250 | core_pubmed_pmc | Random pharmacokinetic profiles of EC-MPS in children with autoimmune disease | Random pharmacokinetic profiles of EC-MPS in children with autoimmune disease Abstract Background Therapy with mycophenolate mofetil (MMF) has become a valuable therapeutic option in children with autoimmune disease. MMF prescription in children with autoimmune diseases differs from that in transplant recipients in ter... |
PMC4225446 | core_pubmed_pmc | Phase IIIb, open-label single-arm trial of darunavir/cobicistat (DRV/COBI): Week 48 subgroup analysis of HIV-1-infected treatment-nave adults | Phase IIIb, open-label single-arm trial of darunavir/cobicistat (DRV/COBI): Week 48 subgroup analysis of HIV-1-infected treatment-nave adults Abstract Abstract Introduction COBI, a PK enhancer with no ARV activity is a more selective cytochrome P450 (CYP)3A inhibitor than ritonavir (RTV), does not induce CYP isozymes, ... |
PMC6394649 | core_pubmed_pmc | Model-Based Conditional Weighted Residuals Analysis for Structural Model Assessment | Model-Based Conditional Weighted Residuals Analysis for Structural Model Assessment Abstract Abstract Nonlinear mixed effects models are widely used to describe longitudinal data to improve the efficiency of drug development process or increase the understanding of the studied disease. In such settings, the appropriate... |
PMC8128736 | core_pubmed_pmc | Towards Evidence-Based Weaning: a Mechanism-Based Pharmacometric Model to Characterize Iatrogenic Withdrawal Syndrome in Critically Ill Children | Towards Evidence-Based Weaning: a Mechanism-Based Pharmacometric Model to Characterize Iatrogenic Withdrawal Syndrome in Critically Ill Children Abstract For the management of iatrogenic withdrawal syndrome (IWS) in children, a quantitative understanding of the dynamics of IWS of commonly used opioids and sedatives is ... |
PMC3210071 | core_pubmed_pmc | Bioequivalence assessment of two formulations of ibuprofen | Bioequivalence assessment of two formulations of ibuprofen Abstract Abstract Background: This study assessed the relative bioavailability of two formulations of ibuprofen. The first formulation was Doloraz ® , produced by Al-Razi Pharmaceutical Company, Amman, Jordan. The second forumulation was Brufen ® , manufactured... |
PMC10861969 | core_pubmed_pmc | Population pharmacokinetic approach to guide personalized sertraline treatment in Chinese patients | Population pharmacokinetic approach to guide personalized sertraline treatment in Chinese patients Abstract Abstract Object: Sertraline is a first-line SSRI for the treatment of depression and has the same effectiveness along with a superior safety profile compared to other medications. There are few population pharmac... |
PMC7843972 | core_pubmed_pmc | Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness | Oral absorption and drug interaction kinetics of moxifloxacin in an animal model of weightlessness Abstract Abstract To investigate the effect of simulated weightlessness on the pharmacokinetics of orally administered moxifloxacin and the antacid Maalox or the antidiarrheal Pepto-Bismol using a tail-suspended (TS) rat ... |
PMC4492733 | core_pubmed_pmc | Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates | Pharmacodynamic assays to facilitate preclinical and clinical development of pre-mRNA splicing modulatory drug candidates Abstract The spliceosome has recently emerged as a new target for cancer chemotherapy and novel antitumor spliceosome targeted agents are under development. Here, we describe two types of novel phar... |
PMC8311652 | core_pubmed_pmc | Drugs and Epigenetic Molecular Functions. A Pharmacological Data Scientometric Analysis | Drugs and Epigenetic Molecular Functions. A Pharmacological Data Scientometric Analysis Abstract Interactions of drugs with the classical epigenetic mechanism of DNA methylation or histone modification are increasingly being elucidated mechanistically and used to develop novel classes of epigenetic therapeutics. A data... |
PMC7496732 | core_pubmed_pmc | Effect of Fremanezumab Monthly and Quarterly Doses on Efficacy Responses | Effect of Fremanezumab Monthly and Quarterly Doses on Efficacy Responses Abstract Objective Exposure‐response (E‐R) models were developed to provide a description of the time‐course of treatment effect for monthly and quarterly dosing regimens of fremanezumab. Background Fremanezumab is a monoclonal antibody for preven... |
PMC3428607 | core_pubmed_pmc | Pre-clinical pharmacokinetics and anti-chlamydial activity of salicylidene acylhydrazide inhibitors of bacterial type III secretion | Pre-clinical pharmacokinetics and anti-chlamydial activity of salicylidene acylhydrazide inhibitors of bacterial type III secretion Abstract Abstract Salicylidene acylhydrazides belong to a class of compounds shown to inhibit bacterial type III secretion (T3S) in pathogenic Gram-negative bacteria. This class of compoun... |
PMC12588635 | core_pubmed_pmc | Effect of CYP3A4 Methylation on Tacrolimus Pharmacokinetics | Effect of CYP3A4 Methylation on Tacrolimus Pharmacokinetics Abstract Supplemental Digital Content is Available in the Text. Key Words: tacrolimus, transplantation, liver, pharmacokinetics, therapeutic drug monitoring Abstract Background: Common genetic variants in CYP3A4 together only explain a limited amount of the va... |
PMC9290614 | core_pubmed_pmc | Population pharmacokinetic and exposure–response analysis of apremilast in Japanese subjects with moderate to severe psoriasis | Population pharmacokinetic and exposure–response analysis of apremilast in Japanese subjects with moderate to severe psoriasis Abstract Abstract Apremilast is an orally available phosphodiesterase 4 inhibitor used for the treatment of moderate to severe psoriasis. The aims of this analysis were to develop a population ... |
PMC5641330 | core_pubmed_pmc | Prediction of a Therapeutic Dose for Buagafuran, a Potent Anxiolytic Agent by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Starting from Pharmacokinetics in Rats and Human | Prediction of a Therapeutic Dose for Buagafuran, a Potent Anxiolytic Agent by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Starting from Pharmacokinetics in Rats and Human Abstract Physiologically based pharmacokinetic (PBPK)/pharmacodynamic (PD) models can contribute to animal-to-human extrapolation ... |
PMC10803350 | core_pubmed_pmc | GC–MS analysis, molecular docking, and pharmacokinetic studies of Multidentia crassa extracts’ compounds for analgesic and anti-inflammatory activities in dentistry | GC–MS analysis, molecular docking, and pharmacokinetic studies of Multidentia crassa extracts’ compounds for analgesic and anti-inflammatory activities in dentistry Abstract Abstract Plant extracts have been useful for oral health or dentistry. However, only a few evidence-based justifications exist. This study evaluat... |
PMC11636752 | core_pubmed_pmc | PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man | PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man Abstract Abstract Cytochrome P450 (CYP)3A4 induction by drugs and pesticides plays a critical role in the enhancement of pyrrolizidine alkaloid (PA) toxicity as it leads to increased formation of hepatot... |
PMC7898862 | core_pubmed_pmc | Phase I study of ABBV-428, a mesothelin-CD40 bispecific, in patients with advanced solid tumors | Phase I study of ABBV-428, a mesothelin-CD40 bispecific, in patients with advanced solid tumors Abstract Background CD40 agonist immunotherapy can potentially license antigen-presenting cells to promote antitumor T-cell activation and re-educate macrophages to destroy tumor stroma. Systemic administration of CD40 agoni... |
PMC4703793 | core_pubmed_pmc | Pharmacokinetic/Pharmacodynamic Correlation of Cefquinome Against Experimental Catheter-Associated Biofilm Infection Due to Staphylococcus aureus | Pharmacokinetic/Pharmacodynamic Correlation of Cefquinome Against Experimental Catheter-Associated Biofilm Infection Due to Staphylococcus aureus Abstract Biofilm formations play an important role in Staphylococcus aureus pathogenesis and contribute to antibiotic treatment failures in biofilm-associated infections. The... |
PMC11536375 | core_pubmed_pmc | Determining the optimum dose of remifentanil in combination with propofol for total intravenous anaesthesia in hysteroscopy under Narcotrend and SPI monitoring | Determining the optimum dose of remifentanil in combination with propofol for total intravenous anaesthesia in hysteroscopy under Narcotrend and SPI monitoring Abstract Abstract Background: Outpatient hysteroscopic surgery requires patients to be anaesthetised and recover quickly, and the drugs used must be safe and ef... |
PMC8618356 | core_pubmed_pmc | Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles | Optimization, Characterization and Pharmacokinetic Study of Meso-Tetraphenylporphyrin Metal Complex-Loaded PLGA Nanoparticles Abstract Abstract The selection of technological parameters for nanoparticle formulation represents a complicated development phase. Therefore, the statistical analysis based on Box–Behnken meth... |
PMC10145446 | core_pubmed_pmc | Developing a Formulation Strategy Coupled with PBPK Modeling and Simulation for the Weakly Basic Drug Albendazole | Developing a Formulation Strategy Coupled with PBPK Modeling and Simulation for the Weakly Basic Drug Albendazole Abstract Albendazole (ABZ) is a weakly basic drug that undergoes extensive presystemic metabolism after oral administration and converts to its active form albendazole sulfoxide (ABZ_SO). The absorption of ... |
PMC5459654 | core_pubmed_pmc | Prevention of Surgical Site Infections and Biofilms: Pharmacokinetics of Subcutaneous Cefazolin and Metronidazole in a Tumescent Lidocaine Solution | Prevention of Surgical Site Infections and Biofilms: Pharmacokinetics of Subcutaneous Cefazolin and Metronidazole in a Tumescent Lidocaine Solution Abstract Supplemental Digital Content is available in the text. Abstract Background: Tumescent anesthesia antibiotic delivery (TAAD) consists of subcutaneous infiltration o... |
PMC6304572 | core_pubmed_pmc | Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLC/QQQ-MS/MS | Simultaneous Evaluation of the Influence of Panax ginseng on the Pharmacokinetics of Three Diester Alkaloids after Oral Administration of Aconiti Lateralis Radix in Rats Using UHPLC/QQQ-MS/MS Abstract Abstract Objectives To investigate whether Panax ginseng ( P. ginseng ) could affect the metabolism of Diester Alkaloid... |
PMC11079547 | core_pubmed_pmc | Evaluation of potential drug–drug interactions with medical cannabis | Evaluation of potential drug–drug interactions with medical cannabis Abstract Abstract Cannabis–drug interactions have caused significant concerns, mainly due to their role in the cytochrome P450 (CYP) enzyme‐mediated metabolic pathway of numerous medications. A systematic review was conducted to gain an overview of th... |
PMC5158093 | core_pubmed_pmc | Relative Bioavailabilities of Lisdexamfetamine Dimesylate and d -Amphetamine in Healthy Adults in an Open-Label, Randomized, Crossover Study After Mixing Lisdexamfetamine Dimesylate With Food or Drink | Relative Bioavailabilities of Lisdexamfetamine Dimesylate and d -Amphetamine in Healthy Adults in an Open-Label, Randomized, Crossover Study After Mixing Lisdexamfetamine Dimesylate With Food or Drink Abstract Supplemental Digital Content is Available in the Text. Key Words: d -amphetamine, lisdexamfetamine, pharmacoki... |
PMC11090672 | core_pubmed_pmc | Advanced UPLC-MS/MS Method for the Quantification of SIPI6398 in Rat Plasma and Its Pharmacokinetic Characterization | Advanced UPLC-MS/MS Method for the Quantification of SIPI6398 in Rat Plasma and Its Pharmacokinetic Characterization Abstract SIPI6398 is a novel anti-schizophrenia agent with a new mechanism of action and demonstrates better target selectivity and safety compared to its competitors. However, few in vivo studies on the... |
PMC3282610 | core_pubmed_pmc | Self-microemulsifying drug-delivery system for improved oral bioavailability of probucol: preparation and evaluation | Self-microemulsifying drug-delivery system for improved oral bioavailability of probucol: preparation and evaluation Abstract The objective of our investigation was to design a self-microemulsifying drug-delivery system (SMEDDS) to improve the bioavailability of probucol. SMEDDS was composed of probucol, olive oil, Lau... |
PMC7073791 | core_pubmed_pmc | A first-in-human phase 1 dose escalation study of spartalizumab (PDR001), an anti–PD-1 antibody, in patients with advanced solid tumors | A first-in-human phase 1 dose escalation study of spartalizumab (PDR001), an anti–PD-1 antibody, in patients with advanced solid tumors Abstract Abstract Background Spartalizumab is a humanized IgG4κ monoclonal antibody that binds programmed death-1 (PD-1) and blocks its interaction with PD-L1 and PD-L2. This phase 1/2... |
PMC6050661 | core_pubmed_pmc | A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice | A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice Abstract Background The yeast-like fungi Pneumocystis, resides in lung alveoli and can cause a lethal infection known as Pneumocystis pneumonia (PCP) in hosts with impaired immune systems. Current therapies for PCP, such as trimethoprim-... |
PMC9728581 | core_pubmed_pmc | Population pharmacokinetics and dosing optimization of unbound teicoplanin in Chinese adult patients | Population pharmacokinetics and dosing optimization of unbound teicoplanin in Chinese adult patients Abstract Objectives: To develop a population pharmacokinetic (PopPK) model describing unbound teicoplanin concentrations in Chinese adult patients and perform Monte Carlo simulations to optimize the dosing regimens. Met... |
PMC10388746 | core_pubmed_pmc | An update on placental drug transport and its relevance to fetal drug exposure | An update on placental drug transport and its relevance to fetal drug exposure Abstract Abstract Pregnant women are often complicated with diseases that require treatment with medication. Most drugs administered to pregnant women are off-label without the necessary dose, efficacy, and safety information. Knowledge conc... |
PMC5968095 | core_pubmed_pmc | A Computational Workflow for Probabilistic Quantitative in Vitro to in Vivo Extrapolation | A Computational Workflow for Probabilistic Quantitative in Vitro to in Vivo Extrapolation Abstract Abstract A computational workflow was developed to facilitate the process of quantitative in vitro to in vivo extrapolation (QIVIVE), specifically the translation of in vitro concentration-response to in vivo dose-respons... |
PMC11609414 | core_pubmed_pmc | Research Progress on Cyclic-Peptide Functionalized Nanoparticles for Tumor-Penetrating Delivery | Research Progress on Cyclic-Peptide Functionalized Nanoparticles for Tumor-Penetrating Delivery Abstract Abstract A key challenge in cancer treatment is the effective delivery of drugs into deep regions of tumor tissues, which are impermeable due to abnormal vascular network, increased interstitial fluid pressure (IFP)... |
PMC7874534 | core_pubmed_pmc | Coexisting flavonoids and administration route effect on pharmacokinetics of Puerarin in MCAO rats | Coexisting flavonoids and administration route effect on pharmacokinetics of Puerarin in MCAO rats Abstract Abstract A pharmacokinetic comparison was made to evaluate the influence from other components in the Radix Puerariae Extract on pharmacokinetic behavior of Puerarin. Samples of blood and brain were collected by ... |
PMC9343874 | core_pubmed_pmc | Comparative Pharmacokinetics of Cinobufacini Capsule and Injection by UPLC-MS/MS | Comparative Pharmacokinetics of Cinobufacini Capsule and Injection by UPLC-MS/MS Abstract Abstract Cinobufacini capsule and injection are two different formulations from the same source, obtained from the extraction of the skin of Bufo bufo gargarizans Cantor, which have been approved by the Chinese State Food and Drug... |
PMC8001859 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network | Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network Abstract Abstract The noradrenaline and dopamine reuptake inhibitor bupropion is metabolized by CYP2B6 and recommended by the FDA as the only sensitive substrate for clinical CYP2B6 drug–drug i... |
PMC4317228 | core_pubmed_pmc | Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor | Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor Abstract Abstract Compounds modulating metabotropic glutamate type 2 (mGlu2) receptor activity may have therapeutic benefits in treating psychiatric disorders like schizophrenia and anxiety. The pharmac... |
PMC4238735 | core_pubmed_pmc | Pharmacokinetics of Tedizolid Following Oral Administration: Single and Multiple Dose, Effect of Food, and Comparison of Two Solid Forms of the Prodrug | Pharmacokinetics of Tedizolid Following Oral Administration: Single and Multiple Dose, Effect of Food, and Comparison of Two Solid Forms of the Prodrug Abstract Objectives The single- and multiple-dose pharmacokinetics (PK) of tedizolid were examined after oral administration of tedizolid phosphate disodium (TPD), incl... |
PMC9548535 | core_pubmed_pmc | Development of a pediatric physiologically-based pharmacokinetic model to support recommended dosing of atezolizumab in children with solid tumors | Development of a pediatric physiologically-based pharmacokinetic model to support recommended dosing of atezolizumab in children with solid tumors Abstract Background: Atezolizumab has been studied in multiple indications for both pediatric and adult patient populations. Generally, clinical studies enrolling pediatric ... |
PMC8451859 | core_pubmed_pmc | Evaluation of Drug‐Drug Interaction Liability for Buprenorphine Extended‐Release Monthly Injection Administered by Subcutaneous Route | Evaluation of Drug‐Drug Interaction Liability for Buprenorphine Extended‐Release Monthly Injection Administered by Subcutaneous Route Abstract Abstract Buprenorphine extended‐release (BUP‐XR) formulation is a once‐monthly subcutaneous injection for the treatment of opioid use disorder (OUD). Buprenorphine undergoes ext... |
PMC9905117 | core_pubmed_pmc | Characterization of the metabolism of eupalinolide A and B by carboxylesterase and cytochrome P450 in human liver microsomes | Characterization of the metabolism of eupalinolide A and B by carboxylesterase and cytochrome P450 in human liver microsomes Abstract Abstract Eupalinolide A (EA; Z-configuration) and eupalinolide B (EB; E-configuration) are bioactive cis-trans isomers isolated from Eupatorii Lindleyani Herba that exert anti-inflammato... |
PMC8894944 | core_pubmed_pmc | Regression Analysis to Estimate the Factor VIII Activity of Patients with Hemophilia A Without Inhibitor who Received Emicizumab Therapy | Regression Analysis to Estimate the Factor VIII Activity of Patients with Hemophilia A Without Inhibitor who Received Emicizumab Therapy Abstract Abstract Background Emicizumab, a bispecific monoclonal antibody for hemophilia A (HA), has strong pharmacodynamic effects in several coagulation assays resulting in dosing d... |
PMC2880336 | core_pubmed_pmc | New anticoagulants for the prevention of venous thromboembolism | New anticoagulants for the prevention of venous thromboembolism Abstract Anticoagulant drugs have an essential role in the prevention and treatment of thromboembolic diseases. Currently available anticoagulants substantially reduce the incidence of thromboembolic events in a number of clinical conditions. However, thes... |
PMC10481538 | core_pubmed_pmc | Bioanalytical method validation and application to a phase 1, double-blind, randomized pharmacokinetic trial of a standardized Centella asiatica (L.) Urban water extract product in healthy older adults | Bioanalytical method validation and application to a phase 1, double-blind, randomized pharmacokinetic trial of a standardized Centella asiatica (L.) Urban water extract product in healthy older adults Abstract Introduction: Centella asiatica is an herbaceous plant reputed in Eastern medicine to improve memory. Preclin... |
PMC4716579 | core_pubmed_pmc | Semi‐Mechanism‐Based Population Pharmacokinetic Modeling of the Hedgehog Pathway Inhibitor Vismodegib | Semi‐Mechanism‐Based Population Pharmacokinetic Modeling of the Hedgehog Pathway Inhibitor Vismodegib Abstract Abstract Vismodegib, approved for the treatment of advanced basal cell carcinoma, has shown unique pharmacokinetic (PK) nonlinearity and binding to α1‐acid glycoprotein (AAG) in humans. A semi‐mechanism‐based ... |
PMC9230074 | core_pubmed_pmc | Development of Photoremovable Linkers as a Novel Strategy to Improve the Pharmacokinetics of Drug Conjugates and Their Potential Application in Antibody–Drug Conjugates for Cancer Therapy | Development of Photoremovable Linkers as a Novel Strategy to Improve the Pharmacokinetics of Drug Conjugates and Their Potential Application in Antibody–Drug Conjugates for Cancer Therapy Abstract Abstract Although there have been extensive research and progress on the discovery of anticancer drug over the years, the a... |
PMC12337008 | core_pubmed_pmc | Predictors of caspofungin exposure-response relationship: a retrospective cohort study on therapeutic drug monitoring parameters | Predictors of caspofungin exposure-response relationship: a retrospective cohort study on therapeutic drug monitoring parameters Abstract Introduction This study aimed to characterize the exposure-response relationship of caspofungin through analysis of trough serum concentration (Cmin) associated with clinical efficac... |
PMC4266495 | core_pubmed_pmc | Preparation, Pharmacokinetics, Biodistribution, Antitumor Efficacy and Safety of Lx2-32c-Containing Liposome | Preparation, Pharmacokinetics, Biodistribution, Antitumor Efficacy and Safety of Lx2-32c-Containing Liposome Abstract Lx2-32c is a novel taxane that has been demonstrated to have robust antitumor activity against different types of tumors including several paclitaxel-resistant neoplasms. Since the delivery vehicles for... |
PMC6887677 | core_pubmed_pmc | Role of equilibrative nucleoside transporter 1 (ENT1) in the disposition of cytarabine in mice | Role of equilibrative nucleoside transporter 1 (ENT1) in the disposition of cytarabine in mice Abstract Abstract Cytarabine (Ara‐C) is a nucleoside analog used in the treatment of acute myeloid leukemia (AML). Despite the many years of clinical use, the identity of the transporter(s) involved in the disposition of Ara‐... |
PMC12382689 | core_pubmed_pmc | Pharmacokinetics/Pharmacodynamics-Based Repositioning of Cefmetazole and Flomoxef in Extended-Spectrum β-Lactamase-Producing Enterobacterales Treatment: An Injectable Carbapenem-Sparing and Outpatient Strategy | Pharmacokinetics/Pharmacodynamics-Based Repositioning of Cefmetazole and Flomoxef in Extended-Spectrum β-Lactamase-Producing Enterobacterales Treatment: An Injectable Carbapenem-Sparing and Outpatient Strategy Abstract Infections caused by extended-spectrum β-lactamase-producing Enterobacterales (ESBL-Es) pose a signif... |
PMC8375633 | core_pubmed_pmc | Synchronous LC-MS/MS determination of pantoprazole and amitriptyline in rabbit plasma: application to comparative in vivo pharmacokinetic study of novel formulated effervescent granules with its marketed tablet dosage form | Synchronous LC-MS/MS determination of pantoprazole and amitriptyline in rabbit plasma: application to comparative in vivo pharmacokinetic study of novel formulated effervescent granules with its marketed tablet dosage form Abstract Abstract In the present study the bioavailability and pharmacokinetics properties of pan... |
PMC11962002 | core_pubmed_pmc | Traditional usages, chemical metabolites, pharmacological activities, and pharmacokinetics of Boesenbergia rotunda (L.) Mansf.: a comprehensive review | Traditional usages, chemical metabolites, pharmacological activities, and pharmacokinetics of Boesenbergia rotunda (L.) Mansf.: a comprehensive review Abstract Abstract Boesenbergia rotunda : (L.) Mansf. (family Zingiberaceae), also known as fingerroot, is a medicinal and food plant that is widely distributed in southe... |
PMC3018506 | core_pubmed_pmc | Private Drinking Water Wells as a Source of Exposure to Perfluorooctanoic Acid (PFOA) in Communities Surrounding a Fluoropolymer Production Facility | Private Drinking Water Wells as a Source of Exposure to Perfluorooctanoic Acid (PFOA) in Communities Surrounding a Fluoropolymer Production Facility Abstract Background The C8 Health Project was established in 2005 to collect data on perfluorooctanoic acid (PFOA, or C8) and human health in Ohio and West Virginia commun... |
PMC5434340 | core_pubmed_pmc | Pharmacodynamics of Isavuconazole for Invasive Mold Disease: Role of Galactomannan for Real-Time Monitoring of Therapeutic Response | Pharmacodynamics of Isavuconazole for Invasive Mold Disease: Role of Galactomannan for Real-Time Monitoring of Therapeutic Response Abstract Abstract Background. The ability to make early therapeutic decisions when treating invasive aspergillosis using changes in biomarkers as a surrogate for therapeutic response could... |
PMC4174509 | core_pubmed_pmc | Accuracy and Completeness of Drug Information in Wikipedia: A Comparison with Standard Textbooks of Pharmacology | Accuracy and Completeness of Drug Information in Wikipedia: A Comparison with Standard Textbooks of Pharmacology Abstract The online resource Wikipedia is increasingly used by students for knowledge acquisition and learning. However, the lack of a formal editorial review and the heterogeneous expertise of contributors ... |
PMC6521589 | core_pubmed_pmc | Developmental Pharmacokinetics and Safety of Ibuprofen and Its Enantiomers in the Conventional Pig as Potential Pediatric Animal Model | Developmental Pharmacokinetics and Safety of Ibuprofen and Its Enantiomers in the Conventional Pig as Potential Pediatric Animal Model Abstract Abstract Pediatric drug development, especially in disease areas that only affect children, can be stimulated by using juvenile animal models not only for general safety studie... |
PMC9087011 | core_pubmed_pmc | Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID‐19 Trial of Nirmatrelvir | Innovative Randomized Phase I Study and Dosing Regimen Selection to Accelerate and Inform Pivotal COVID‐19 Trial of Nirmatrelvir Abstract Coronavirus disease 2019 (COVID‐19) is a continued leading cause of hospitalization and death. Safe, efficacious COVID‐19 antivirals are needed urgently. Nirmatrelvir (PF‐07321332), ... |
PMC6615816 | core_pubmed_pmc | Assessing the safety and pharmacokinetics of the monoclonal antibodies, VRC07-523LS and PGT121 in HIV negative women in South Africa: study protocol for the CAPRISA 012A randomised controlled phase I trial | Assessing the safety and pharmacokinetics of the monoclonal antibodies, VRC07-523LS and PGT121 in HIV negative women in South Africa: study protocol for the CAPRISA 012A randomised controlled phase I trial Abstract Abstract Introduction Despite extensive prevention campaigns and scale-up of antiretroviral therapy, HIV ... |
PMC3293174 | core_pubmed_pmc | Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C | Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C Abstract Abstract Background Chronic hepatitis C is associated with significant morbidity and mortality as a consequence of progression to cirrhosis, hepatocellular carcinoma, and liver failure. Current treatment ... |
PMC3573806 | core_pubmed_pmc | Formulation and in vitro and in vivo evaluation of film-coated montelukast sodium tablets using Opadry ® yellow 20A82938 on an industrial scale | Formulation and in vitro and in vivo evaluation of film-coated montelukast sodium tablets using Opadry ® yellow 20A82938 on an industrial scale Abstract Purpose: The aim of this study was to formulate stable film-coated montelukast sodium (MS) tablets using Opadry ® yellow 20A82938 (Montikast ® tablets) and to evaluate... |
PMC5822840 | core_pubmed_pmc | Drug–drug interactions involving antidepressants: focus on desvenlafaxine | Drug–drug interactions involving antidepressants: focus on desvenlafaxine Abstract Abstract Psychiatric and physical conditions often coexist, and there is robust evidence that associates the frequency of depression with single and multiple physical conditions. More than half of patients with depression may have at lea... |
PMC6451710 | core_pubmed_pmc | Impact of CYP3A4*22 on Pazopanib Pharmacokinetics in Cancer Patients | Impact of CYP3A4*22 on Pazopanib Pharmacokinetics in Cancer Patients Abstract Background and Objective As pazopanib plasma trough concentrations are correlated with treatment outcome, we explored whether single nucleotide polymorphisms in the elimination pathway of pazopanib affect systemic pazopanib concentrations. Me... |
PMC5320447 | core_pubmed_pmc | Scale up and pharmacokinetic study of a novel mutated chimeric tissue plasminogen activator (mt-PA) in rats | Scale up and pharmacokinetic study of a novel mutated chimeric tissue plasminogen activator (mt-PA) in rats Abstract Because of high mortality caused by cardiovascular diseases, various fibrinolytic agents with diverse pharmacokinetic and pharmacodynamic properties have been developed. A novel mutated chimeric tissue p... |
PMC11579104 | core_pubmed_pmc | A quantitative systems pharmacology model of plasma kallikrein-kinin system dysregulation in hereditary angioedema | A quantitative systems pharmacology model of plasma kallikrein-kinin system dysregulation in hereditary angioedema Abstract Abstract Hereditary angioedema (HAE) due to C1-inhibitor deficiency is a rare, debilitating, genetic disorder characterized by recurrent, unpredictable, attacks of edema. The clinical symptoms of ... |
PMC5890720 | core_pubmed_pmc | A model-informed preclinical approach for prediction of clinical pharmacodynamic interactions of anti-TB drug combinations | A model-informed preclinical approach for prediction of clinical pharmacodynamic interactions of anti-TB drug combinations Abstract Abstract Background Identification of pharmacodynamic interactions is not reasonable to carry out in a clinical setting for many reasons. The aim of this work was to develop a model-inform... |
PMC7961457 | core_pubmed_pmc | Rp-HPLC Determination of Quercetin in a Novel D-α-Tocopherol Polyethylene Glycol 1000 Succinate Based SNEDDS Formulation: Pharmacokinetics in Rat Plasma | Rp-HPLC Determination of Quercetin in a Novel D-α-Tocopherol Polyethylene Glycol 1000 Succinate Based SNEDDS Formulation: Pharmacokinetics in Rat Plasma Abstract Despite its proven efficacy in diverse metabolic disorders, quercetin (QU) for clinical use is still limited because of its low bioavailability. D-α-Tocophero... |
PMC6989225 | core_pubmed_pmc | Pharmacokinetics of fixed-dose combination of rosuvastatin 20 mg and ezetimibe 10 mg compared to concurrent administration of individual tablets in healthy Korean subjects | Pharmacokinetics of fixed-dose combination of rosuvastatin 20 mg and ezetimibe 10 mg compared to concurrent administration of individual tablets in healthy Korean subjects Abstract Abstract This study aimed to compare the pharmacokinetics of fixed-dose combination (FDC) tablet of rosuvastatin 20 mg/ezetimibe 10 mg with... |
PMC7042483 | core_pubmed_pmc | Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system | Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system Abstract In this study, we show that the percutaneous absorption and brain distribution of tetramethylpyrazine (TMP) is enhanced when combined with borneol (BN) in a micr... |
PMC12843901 | core_pubmed_pmc | Bacteriophage Therapy: Overcoming Antimicrobial Resistance Through Advanced Delivery Methods | Bacteriophage Therapy: Overcoming Antimicrobial Resistance Through Advanced Delivery Methods Abstract Abstract Microbial resistance to antibiotics necessitates the development of alternative treatments to address the challenges posed by severe bacterial infections. Bacteriophages are regaining clinical relevance, but t... |
PMC8663851 | core_pubmed_pmc | Development of a simple method for measuring tedizolid concentration in human serum using HPLC with a fluorescent detector | Development of a simple method for measuring tedizolid concentration in human serum using HPLC with a fluorescent detector Abstract Abstract The objective of the present study was to develop a method to measure tedizolid (TZD) concentration for studying target concentration intervention, pharmacokinetics, and pharmacod... |
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