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PMC11590947 | core_pubmed_pmc | Effect of Body Size on Plasma and Tissue Pharmacokinetics of Danofloxacin in Rainbow Trout ( Oncorhynchus mykiss ) | Effect of Body Size on Plasma and Tissue Pharmacokinetics of Danofloxacin in Rainbow Trout ( Oncorhynchus mykiss ) Abstract Simple Summary Changes in body size in fish can alter the pharmacokinetics of drugs, thereby affecting their therapeutic efficacy. Fish are among the animals that exhibit the greatest variability ... |
PMC9343858 | core_pubmed_pmc | Proteomics and Metabolomics Unveil Codonopsis pilosula (Franch.) Nannf. Ameliorates Gastric Precancerous Lesions via Regulating Energy Metabolism | Proteomics and Metabolomics Unveil Codonopsis pilosula (Franch.) Nannf. Ameliorates Gastric Precancerous Lesions via Regulating Energy Metabolism Abstract Abstract Objective: This study aimed to systematically evaluate the efficacy of Codonopsis pilosula (Franch.) Nannf. ( Codonopsis Radix , CR) and reveal the mechanis... |
PMC10085936 | core_pubmed_pmc | Population Pharmacokinetics and Exposure–Response Analysis for the Phase 3 COSMIC-311 Trial of Cabozantinib for Radioiodine-Refractory Differentiated Thyroid Cancer | Population Pharmacokinetics and Exposure–Response Analysis for the Phase 3 COSMIC-311 Trial of Cabozantinib for Radioiodine-Refractory Differentiated Thyroid Cancer Abstract Abstract Background and Objective In the USA, cabozantinib was approved for the treatment of patients aged ≥ 12 years with radioiodine-refractory ... |
PMC12221929 | core_pubmed_pmc | Increasing plasma ketamine concentrations decrease the minimum alveolar concentration of isoflurane in rabbits | Increasing plasma ketamine concentrations decrease the minimum alveolar concentration of isoflurane in rabbits Abstract Abstract To evaluate the effects of increasing plasma ketamine concentration on isoflurane minimum alveolar concentration (MAC) in rabbits, six New Zealand white rabbits weighing 4.21 ± 0.35 kg were a... |
PMC12287809 | core_pubmed_pmc | A Multicenter Randomized Controlled Study on Pharmacokinetic‐Guided Vancomycin Use in Children With Severe Infections | A Multicenter Randomized Controlled Study on Pharmacokinetic‐Guided Vancomycin Use in Children With Severe Infections Abstract ABSTRACT This study is a multicenter, randomized controlled prospective trial aimed at evaluating the effects of two vancomycin pharmacokinetics/pharmacodynamics (PK/PD) parameters on clinical ... |
PMC9558428 | core_pubmed_pmc | A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR) | A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR) Abstract Background Granulocyte–macrophage colony-stimulating factor (GM-CSF) and dysregulated myeloid cell responses are implicated in the pathophysiology and severity of COVID-19. Methods In this randomised, sequential, multicentre, place... |
PMC9137962 | core_pubmed_pmc | Therapeutic Drug Monitoring of Antifungal Agents in Critically Ill Patients: Is There a Need for Dose Optimisation? | Therapeutic Drug Monitoring of Antifungal Agents in Critically Ill Patients: Is There a Need for Dose Optimisation? Abstract Abstract Invasive fungal infections are an important cause of morbidity and mortality, especially in critically ill patients. Increasing resistance rates and inadequate antifungal exposure have b... |
PMC9494962 | core_pubmed_pmc | Do Different Sutures with Triclosan Have Different Antimicrobial Activities? A Pharmacodynamic Approach | Do Different Sutures with Triclosan Have Different Antimicrobial Activities? A Pharmacodynamic Approach Abstract (1) Background: Three antimicrobial absorbable sutures have different triclosan (TS) loads, triclosan release kinetics and hydrolysis times. This in vitro study aims to analyse and compare their antimicrobia... |
PMC2912772 | core_pubmed_pmc | A Conserved Behavioral State Barrier Impedes Transitions between Anesthetic-Induced Unconsciousness and Wakefulness: Evidence for Neural Inertia | A Conserved Behavioral State Barrier Impedes Transitions between Anesthetic-Induced Unconsciousness and Wakefulness: Evidence for Neural Inertia Abstract One major unanswered question in neuroscience is how the brain transitions between conscious and unconscious states. General anesthetics offer a controllable means to... |
PMC4160330 | core_pubmed_pmc | Synthesis, pharmacokinetics, and biological use of lysine-modified single-walled carbon nanotubes | Synthesis, pharmacokinetics, and biological use of lysine-modified single-walled carbon nanotubes Abstract We aimed to create a more robust and more accessible standard for amine-modifying single-walled carbon nanotubes (SWCNTs). A 1,3-cycloaddition was developed using an azomethine ylide, generated by reacting parafor... |
PMC6354687 | core_pubmed_pmc | Model-dependent pharmacokinetic analysis of enalapril administered to healthy adult volunteers using orodispersible minitablets for use in pediatrics | Model-dependent pharmacokinetic analysis of enalapril administered to healthy adult volunteers using orodispersible minitablets for use in pediatrics Abstract Abstract Introduction Comparative pharmacokinetic (PK) data analysis of drugs administered using developed child-appropriate and market authorized dosage formula... |
PMC11360054 | core_pubmed_pmc | Synthetic Naphthoquinone Inhibits Herpes Simplex Virus Type-1 Replication Targeting Na + , K + ATPase | Synthetic Naphthoquinone Inhibits Herpes Simplex Virus Type-1 Replication Targeting Na + , K + ATPase Abstract Since 1970 acyclovir (ACV) has been the reference drug in treating herpes simplex virus (HSV) infections. However, resistant herpes simplex virus type 1 (HSV-1) strains have emerged, narrowing the treatment ef... |
PMC7912692 | core_pubmed_pmc | Evidence for Establishing the Clinical Breakpoint of Cefquinome against Haemophilus Parasuis in China | Evidence for Establishing the Clinical Breakpoint of Cefquinome against Haemophilus Parasuis in China Abstract Abstract Haemophilus parasuis can cause high morbidity and mortality in swine. Cefquinome possesses excellent antibacterial activity against pathogens causing diseases of the respiratory tract. This study aime... |
PMC12582058 | core_pubmed_pmc | Scoping review of associations between cytochrome P450 3A4/5 single nucleotide polymorphisms and risk factors for fentanyl overdose | Scoping review of associations between cytochrome P450 3A4/5 single nucleotide polymorphisms and risk factors for fentanyl overdose Abstract ABSTRACT Introduction Fentanyl overdose is a public health crisis in the United States, as fentanyl was implicated in nearly 70% of drug overdose deaths in 2023. To provide insigh... |
PMC3689913 | core_pubmed_pmc | Pharmacokinetic Dose Proportionality Between Two Strengths (12.5 mg and 25 mg) of Doxylamine Hydrogen Succinate Film-Coated Tablets in Fasting State: A Single-Dose, Randomized, Two-Period Crossover Study in Healthy Volunteers | Pharmacokinetic Dose Proportionality Between Two Strengths (12.5 mg and 25 mg) of Doxylamine Hydrogen Succinate Film-Coated Tablets in Fasting State: A Single-Dose, Randomized, Two-Period Crossover Study in Healthy Volunteers Abstract Background Doxylamine succinate, an ethanolamine-based antihistamine, is used in the ... |
PMC10902586 | core_pubmed_pmc | Development of a model to predict vancomycin serum concentration during continuous infusion of vancomycin in critically ill pediatric patients | Development of a model to predict vancomycin serum concentration during continuous infusion of vancomycin in critically ill pediatric patients Abstract Abstract Vancomycin is a frequently used antibiotic in intensive care units, and the patient’s renal clearance affects the pharmacokinetic characteristics of vancomycin... |
PMC9372417 | core_pubmed_pmc | A permeability‐ and perfusion‐based PBPK model for improved prediction of concentration‐time profiles | A permeability‐ and perfusion‐based PBPK model for improved prediction of concentration‐time profiles Abstract Abstract To improve predictions of concentration‐time (C‐t) profiles of drugs, a new physiologically based pharmacokinetic modeling framework (termed ‘PermQ’) has been developed. This model includes permeabili... |
PMC6448905 | core_pubmed_pmc | Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes | Evidence-based prioritisation and enrichment of genes interacting with metformin in type 2 diabetes Abstract Aims/hypothesis There is an extensive body of literature suggesting the involvement of multiple loci in regulating the action of metformin; most findings lack replication, without which distinguishing true-posit... |
PMC9907522 | core_pubmed_pmc | A Phase 2, Randomized, Multicenter, Placebo-Controlled, Proof-of-Concept Trial of Oral Fexinidazole in Adults With Chronic Indeterminate Chagas Disease | A Phase 2, Randomized, Multicenter, Placebo-Controlled, Proof-of-Concept Trial of Oral Fexinidazole in Adults With Chronic Indeterminate Chagas Disease Abstract Abstract Background Chagas disease (CD) has significant global health impact, but safe, effective treatments remain elusive. The nitroimidazole fexinidazole is... |
PMC5370104 | core_pubmed_pmc | Pharmacokinetics of a single 1g dose of azithromycin in rectal tissue in men | Pharmacokinetics of a single 1g dose of azithromycin in rectal tissue in men Abstract Chlamydia is the most common bacterial sexually transmitted infection among men who have sex with men. Repeat infection following treatment with 1g azithromycin is common and treatment failure of up to 22% has been reported. This stud... |
PMC6706711 | core_pubmed_pmc | How Much Vancomycin Dose Is Enough For The MRSA Infection in Pediatric Patients With Various Degrees of Renal Function? | How Much Vancomycin Dose Is Enough For The MRSA Infection in Pediatric Patients With Various Degrees of Renal Function? Abstract Abstract Today, an increase in vancomycin dose has been proposed to ensure efficacy. However, the risk of nephrotoxicity will increase with the dose. The aim of this study was to evaluate the... |
PMC9210257 | core_pubmed_pmc | Pharmacokinetics of bisphenol A in humans following dermal administration | Pharmacokinetics of bisphenol A in humans following dermal administration Abstract Background: Human exposures to bisphenol A (BPA) are widespread. The current study addresses uncertainties regarding human pharmacokinetics of BPA following dermal exposure. Objective: To examine the absorption, distribution, metabolism ... |
PMC3403372 | core_pubmed_pmc | Bioequivalence and Population Pharmacokinetic Modeling of Two Forms of Antibiotic, Cefuroxime Lysine and Cefuroxime Sodium, after Intravenous Infusion in Beagle Dogs | Bioequivalence and Population Pharmacokinetic Modeling of Two Forms of Antibiotic, Cefuroxime Lysine and Cefuroxime Sodium, after Intravenous Infusion in Beagle Dogs Abstract Abstract To investigate the bioequivalence and the population pharmacokinetics of cefuroxime lysine and cefuroxime sodium in healthy beagle dogs.... |
PMC11670702 | core_pubmed_pmc | Cannabichromene from full-spectrum hemp extract exerts acute anti-seizure effects through allosteric activation of GABA A receptors | Cannabichromene from full-spectrum hemp extract exerts acute anti-seizure effects through allosteric activation of GABA A receptors Abstract Abstract The approval of Epidiolex, an anti-epileptic drug containing cannabidiol (CBD) as its active component, has brought hope to patients with refractory epilepsy. However, th... |
PMC12196157 | core_pubmed_pmc | Cystoseira spinosa Polysaccharide: A Promising Natural Source for Antioxidant, Pro-Angiogenic, and Wound Healing Applications: In Silico Study | Cystoseira spinosa Polysaccharide: A Promising Natural Source for Antioxidant, Pro-Angiogenic, and Wound Healing Applications: In Silico Study Abstract Background/Objectives: This study evaluated the potential of a polysaccharide (PCS) extracted from the brown alga Cystoseira spinosa as an antioxidant and anti-inflamma... |
PMC5225183 | core_pubmed_pmc | Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay | Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay Abstract Abstract Identification of neurotoxic drugs and environmental chemicals is an important challenge. However, only few tools to address this topic are available. The aim of this study was to develop a neurot... |
PMC12823323 | core_pubmed_pmc | B Cell Differentiation Model for Identifying Predictors of Responses to Rituximab‐Mediated B Cell Depletion in Rheumatic Diseases | B Cell Differentiation Model for Identifying Predictors of Responses to Rituximab‐Mediated B Cell Depletion in Rheumatic Diseases Abstract ABSTRACT Rituximab (RTX), an anti‐CD20 monoclonal antibody, has been used to treat autoimmune diseases such as rheumatoid arthritis (RA). However, variability in therapeutic respons... |
PMC12494607 | core_pubmed_pmc | Exposure-safety Markov modeling of ocular adverse events in patient populations treated with tisotumab vedotin | Exposure-safety Markov modeling of ocular adverse events in patient populations treated with tisotumab vedotin Abstract Tisotumab vedotin (TV), a tissue factor–directed antibody–drug conjugate (ADC), is approved in the US at 2.0 mg/kg every 3 weeks (Q3W) for adult patients with recurrent or metastatic cervical cancer f... |
PMC5862168 | core_pubmed_pmc | An international survey of management of pain and sedation after paediatric cardiac surgery | An international survey of management of pain and sedation after paediatric cardiac surgery Abstract Objective The mainstay of pain treatment after paediatric cardiac surgery is the use of opioids. Current guidelines for its optimal use are based on small, non-randomised clinical trials, and data on the pharmacokinetic... |
PMC10941578 | core_pubmed_pmc | gPKPDviz: A flexible R shiny tool for pharmacokinetic/pharmacodynamic simulations using mrgsolve | gPKPDviz: A flexible R shiny tool for pharmacokinetic/pharmacodynamic simulations using mrgsolve Abstract Abstract GPKPDviz is a Shiny application (app) dedicated to real‐time simulation, visualization, and assessment of the pharmacokinetic/pharmacodynamic (PK/PD) models. Within the app, gPKPDviz is capable of generati... |
PMC12813415 | core_pubmed_pmc | Lannea coromandelica (Houtt.) Merr.: A Comprehensive Review of Its Ethnomedicinal Uses, Phytochemistry and Pharmacological Activity | Lannea coromandelica (Houtt.) Merr.: A Comprehensive Review of Its Ethnomedicinal Uses, Phytochemistry and Pharmacological Activity Abstract ABSTRACT Background and Aims Lannea coromandelica (Houtt.) Merr., a deciduous tropical tree of the Anacardiaceae family, is traditionally used in Asian ethnomedicine to treat diab... |
PMC5719364 | core_pubmed_pmc | High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study | High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study Abstract Abstract Pancreatic cancer is among the most lethal cancers with poorly tolerated treatments. There is increasing interest in using high-dose intravenous ascorbate (IVC) in treating this disease... |
PMC4777250 | core_pubmed_pmc | Modeling the pharmacokinetic‐pharmacodynamic relationship of the monoclonal anti‐macaque‐ IL ‐15 antibody Hu714Mu XH u in cynomolgus monkeys | Modeling the pharmacokinetic‐pharmacodynamic relationship of the monoclonal anti‐macaque‐ IL ‐15 antibody Hu714Mu XH u in cynomolgus monkeys Abstract Abstract Hu714Mu XH u is a recombinant chimeric murine‐human monoclonal antibody directed against interleukin‐15 ( IL ‐15), a proinflammatory cytokine associated with mem... |
PMC9253448 | core_pubmed_pmc | Comparative pharmacokinetics between two tablets of tramadol 37.5 mg/acetaminophen 325 mg and one tablet of tramadol 75 mg/acetaminophen 650 mg for extended-release fixed-dose combination | Comparative pharmacokinetics between two tablets of tramadol 37.5 mg/acetaminophen 325 mg and one tablet of tramadol 75 mg/acetaminophen 650 mg for extended-release fixed-dose combination Abstract An extended-release (ER) fixed-dose combination (FDC) of tramadol 37.5 mg/acetaminophen 325 mg was developed due to the dem... |
PMC6527807 | core_pubmed_pmc | Continuous-Infusion Vancomycin in Neonates: Assessment of a Dosing Regimen and Therapeutic Proposal | Continuous-Infusion Vancomycin in Neonates: Assessment of a Dosing Regimen and Therapeutic Proposal Abstract Introduction: Vancomycin remains the reference antibiotic in neonates for care-related infections caused by ß-lactam–resistant Gram-positive bacteria. Achieving the optimal serum vancomycin level is challenging ... |
PMC8743745 | core_pubmed_pmc | Pharmacokinetics, Pharmacodynamics, and Tolerability of Opicapone in Healthy Chinese and Caucasian Subjects: An Open-Label, Single-Center, Phase 1 Study | Pharmacokinetics, Pharmacodynamics, and Tolerability of Opicapone in Healthy Chinese and Caucasian Subjects: An Open-Label, Single-Center, Phase 1 Study Abstract Introduction This study evaluated the pharmacokinetics (PK) and pharmacodynamics (PD) of single and multiple doses of opicapone (OPC) in healthy Chinese and C... |
PMC8541958 | core_pubmed_pmc | Combination therapy with pazopanib and tivantinib modulates VEGF and c-MET levels in refractory advanced solid tumors | Combination therapy with pazopanib and tivantinib modulates VEGF and c-MET levels in refractory advanced solid tumors Abstract The vascular endothelial growth factor (VEGF)/VEGFR and hepatocyte growth factor (HGF)/c-MET signaling pathways act synergistically to promote angiogenesis. Studies indicate VEGF inhibition lea... |
PMC9906735 | core_pubmed_pmc | Preclinical Evaluation of a Companion Diagnostic Radiopharmaceutical, [ 18 F]PSMA-1007, in a Subcutaneous Prostate Cancer Xenograft Mouse Model | Preclinical Evaluation of a Companion Diagnostic Radiopharmaceutical, [ 18 F]PSMA-1007, in a Subcutaneous Prostate Cancer Xenograft Mouse Model Abstract Several radiolabeled prostate-specific membrane antigen (PSMA)-targeted agents have been developed for detecting prostate cancer, using positron emission tomography im... |
PMC11567552 | core_pubmed_pmc | Integrated virtual screening and MD simulation study to discover potential inhibitors of mycobacterial electron transfer flavoprotein oxidoreductase | Integrated virtual screening and MD simulation study to discover potential inhibitors of mycobacterial electron transfer flavoprotein oxidoreductase Abstract Tuberculosis (TB) continues to be a major global health burden, with high incidence and mortality rates, compounded by the emergence and spread of drug-resistant ... |
PMC12496251 | core_pubmed_pmc | Age-adjusted dosing of fludarabine for lymphodepletion in CAR T-cell therapy: a clinical trial simulation study | Age-adjusted dosing of fludarabine for lymphodepletion in CAR T-cell therapy: a clinical trial simulation study Abstract Key Points • This study shows that age-based FLU dosing can increase the number of individuals within a predefined cumulative area under the curve range. • Age-based or TDM-guided FLU dosing has the ... |
PMC6524925 | core_pubmed_pmc | Molecular Aggregation of Marketed Recombinant FVIII Products: Biochemical Evidence and Functional Effects | Molecular Aggregation of Marketed Recombinant FVIII Products: Biochemical Evidence and Functional Effects Abstract Background Recombinant (rec-) coagulation factor VIII concentrates available for hemophilia A (HA) treatment differ in cell line production and structure, which could affect their pharmacodynamics and immu... |
PMC8097421 | core_pubmed_pmc | AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19 | AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19 Abstract The impact of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19, is global and unprecedented. Although rem... |
PMC11554250 | core_pubmed_pmc | Therapeutic Drug Monitoring of Olanzapine: Effects of Clinical Factors on Plasma Concentrations in Psychiatric Patients | Therapeutic Drug Monitoring of Olanzapine: Effects of Clinical Factors on Plasma Concentrations in Psychiatric Patients Abstract Supplemental Digital Content is Available in the Text. Background: Therapeutic drug monitoring (TDM) is strongly recommended for olanzapine due to its high pharmacokinetic variability. This s... |
PMC10722959 | core_pubmed_pmc | Optimizing Early-stage Clinical Pharmacology Evaluation to Accelerate Clinical Development of Giredestrant in Advanced Breast Cancer | Optimizing Early-stage Clinical Pharmacology Evaluation to Accelerate Clinical Development of Giredestrant in Advanced Breast Cancer Abstract Abstract Purpose: We describe the clinical pharmacology characterization of giredestrant in a first-in-human study. Experimental Design: This phase Ia/Ib dose-escalation/-expansi... |
PMC10719468 | core_pubmed_pmc | Phase I crossover study of DNA‐protein kinase inhibitor peposertib in healthy volunteers: Effect of food and pharmacokinetics of an oral suspension | Phase I crossover study of DNA‐protein kinase inhibitor peposertib in healthy volunteers: Effect of food and pharmacokinetics of an oral suspension Abstract Abstract Peposertib is an orally administered inhibitor of DNA‐dependent protein kinase. We evaluated the effect of food on its pharmacokinetics, and examined the ... |
PMC10780485 | core_pubmed_pmc | Marine Toxins as Pharmaceutical Treasure Troves: A Focus on Saxitoxin Derivatives from a Computational Point of View | Marine Toxins as Pharmaceutical Treasure Troves: A Focus on Saxitoxin Derivatives from a Computational Point of View Abstract This work highlights the significant potential of marine toxins, particularly saxitoxin (STX) and its derivatives, in the exploration of novel pharmaceuticals. These toxins, produced by aquatic ... |
PMC8056735 | core_pubmed_pmc | A randomized controlled trial with a delayed‐type hypersensitivity model using keyhole limpet haemocyanin to evaluate adaptive immune responses in man | A randomized controlled trial with a delayed‐type hypersensitivity model using keyhole limpet haemocyanin to evaluate adaptive immune responses in man Abstract Aims Keyhole limpet haemocyanin (KLH) immunization is a clinical model for the evaluation of human antibody responses. The current study evaluated the anti‐KLH ... |
PMC12927874 | core_pubmed_pmc | A population pharmacokinetic study of ampicillin therapy in hospitalized foals | A population pharmacokinetic study of ampicillin therapy in hospitalized foals Abstract Abstract Background Pharmacokinetic studies on ampicillin in foals are limited, underscoring a relevant gap in knowledge, particularly regarding the treatment of critically ill neonatal foals. Hypothesis/Objectives To evaluate the a... |
PMC10631080 | core_pubmed_pmc | Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials | Efficacy of therapeutic drug monitoring-based antibiotic regimen in critically ill patients: a systematic review and meta-analysis of randomized controlled trials Abstract Abstract Background The efficacy of therapeutic drug monitoring (TDM)-based antimicrobial dosing optimization strategies on pharmacokinetics/pharmac... |
PMC7578248 | core_pubmed_pmc | Perspective for Precision Medicine for Tuberculosis | Perspective for Precision Medicine for Tuberculosis Abstract Tuberculosis is a bacterial infectious disease that is mainly transmitted from human to human via infectious aerosols. Currently, tuberculosis is the leading cause of death by an infectious disease world-wide. In the past decade, the number of patients affect... |
PMC9804109 | core_pubmed_pmc | A new triphenylphosphonium-conjugated amphipathic cationic peptide with improved cell-penetrating and ROS-targeting properties | A new triphenylphosphonium-conjugated amphipathic cationic peptide with improved cell-penetrating and ROS-targeting properties Abstract We study for the first time whether triphenylphosphonium (TPP) moiety can improve cellular delivery and redox properties of amphipathic cationic peptides based on YRFK/YrFK cell-penetr... |
PMC8816528 | core_pubmed_pmc | PBPK Simulation-Based Evaluation of Ganciclovir Crystalluria Risk Factors: Effect of Renal Impairment, Old Age, and Low Fluid Intake | PBPK Simulation-Based Evaluation of Ganciclovir Crystalluria Risk Factors: Effect of Renal Impairment, Old Age, and Low Fluid Intake Abstract Dosing guidance is often lacking for chronic kidney disease (CKD) due to exclusion of such patients from pivotal clinical trials. Physiologically based pharmacokinetic (PBPK) mod... |
PMC5071690 | core_pubmed_pmc | Pharmacokinetics of the Long‐Acting Basal Insulin LY2605541 in Subjects With Varying Degrees of Renal Function | Pharmacokinetics of the Long‐Acting Basal Insulin LY2605541 in Subjects With Varying Degrees of Renal Function Abstract Abstract The pharmacokinetics of LY2605541 (basal insulin peglispro), a novel long‐acting basal insulin analogue, was evaluated in 5 groups of subjects with varying degrees of renal function based on ... |
PMC12108404 | core_pubmed_pmc | Pharmacokinetics of Antibiotics in Crocodiles: A Review | Pharmacokinetics of Antibiotics in Crocodiles: A Review Abstract Simple Summary Antibiotics are used to treat bacterial infections in crocodiles; however, determining appropriate dosing regimens remains challenging due to interspecies variations in pharmacokinetics and the limited availability of pharmacological data. ... |
PMC10603868 | core_pubmed_pmc | Ceftazidime/Avibactam and Meropenem/Vaborbactam for the Management of Enterobacterales Infections: A Narrative Review, Clinical Considerations, and Expert Opinion | Ceftazidime/Avibactam and Meropenem/Vaborbactam for the Management of Enterobacterales Infections: A Narrative Review, Clinical Considerations, and Expert Opinion Abstract This comprehensive review examines the unique attributes, distinctions, and clinical implications of ceftazidime–avibactam (CAZ-AVI) and meropenem–v... |
PMC12637916 | core_pubmed_pmc | Short-term impact of preschool sound exposure on outer hair cell function in young children: An analysis using pressurised distortion product otoacoustic emissions | Short-term impact of preschool sound exposure on outer hair cell function in young children: An analysis using pressurised distortion product otoacoustic emissions Abstract Background Preschool children are regularly exposed to high noise levels that may affect hearing. A previous study has linked preschool noise expos... |
PMC12655191 | core_pubmed_pmc | Toward Genotype-Informed Dosing of Voriconazole: Head-to-Head Simulations Across CYP2C19 Phenotypes Using Population Pharmacokinetic Models | Toward Genotype-Informed Dosing of Voriconazole: Head-to-Head Simulations Across CYP2C19 Phenotypes Using Population Pharmacokinetic Models Abstract Abstract Background/Objective: Voriconazole exhibits nonlinear pharmacokinetics and wide interindividual variability driven by CYP2C19 phenotype and clinical covariates, n... |
PMC8101608 | core_pubmed_pmc | A phase I, single and continuous dose administration study on the safety, tolerability, and pharmacokinetics of neorudin, a novel recombinant anticoagulant protein, in healthy subjects | A phase I, single and continuous dose administration study on the safety, tolerability, and pharmacokinetics of neorudin, a novel recombinant anticoagulant protein, in healthy subjects Abstract Abstract The aim of this study was to evaluate the tolerability, safety, and pharmacokinetics of single and continuous dose ad... |
PMC5651333 | core_pubmed_pmc | ADAM, a hands‐on patient simulator for teaching principles of drug disposition and compartmental pharmacokinetics | ADAM, a hands‐on patient simulator for teaching principles of drug disposition and compartmental pharmacokinetics Abstract Abstract Aims To design, construct and validate a pharmacokinetics simulator that offers students hands‐on opportunities to participate in the design, administration and analysis of oral and intrav... |
PMC10092221 | core_pubmed_pmc | Evaluation of the Pharmacokinetic Drug Interaction of Capmatinib With Itraconazole and Rifampicin and Potential Impact on Renal Transporters in Healthy Subjects | Evaluation of the Pharmacokinetic Drug Interaction of Capmatinib With Itraconazole and Rifampicin and Potential Impact on Renal Transporters in Healthy Subjects Abstract Abstract Capmatinib is a highly specific, potent, and selective mesenchymal–epithelial transition factor inhibitor predominantly eliminated by cytochr... |
PMC9581244 | core_pubmed_pmc | Pharmacokinetics and safety of the two oral cefaclor formulations in healthy chinese subjects in the fasting and postprandial states | Pharmacokinetics and safety of the two oral cefaclor formulations in healthy chinese subjects in the fasting and postprandial states Abstract We conducted a phase I bioequivalence trial in healthy Chinese subjects in the fasting and postprandial states. The goal of this trial was to compare the pharmacokinetics and saf... |
PMC5706442 | core_pubmed_pmc | PARP inhibitors as potential therapeutic agents for various cancers: focus on niraparib and its first global approval for maintenance therapy of gynecologic cancers | PARP inhibitors as potential therapeutic agents for various cancers: focus on niraparib and its first global approval for maintenance therapy of gynecologic cancers Abstract Poly (ADP-ribose) polymerases (PARPs) are an important family of nucleoproteins highly implicated in DNA damage repair. Among the PARP families, t... |
PMC10671713 | core_pubmed_pmc | Gas Chromatography–Mass Spectrometry Detection of Thymoquinone in Oil and Serum for Clinical Pharmacokinetic Studies | Gas Chromatography–Mass Spectrometry Detection of Thymoquinone in Oil and Serum for Clinical Pharmacokinetic Studies Abstract Thymoquinone (TQ) is the primary component of Nigella sativa L. (NS) oil, which is renowned for its potent hepatoprotective effects attributed to its antioxidant, anti-fibrotic, anti-inflammator... |
PMC12331676 | core_pubmed_pmc | Critical dysregulated signaling pathways in drug resistance: highlighting the repositioning of mebendazole for cancer therapy | Critical dysregulated signaling pathways in drug resistance: highlighting the repositioning of mebendazole for cancer therapy Abstract Abstract Background Cancer drug resistance significantly reduces the effectiveness of current anticancer treatments. Multiple dysregulated signaling pathways drive cancer initiation, pr... |
PMC10207934 | core_pubmed_pmc | Oral antibiotics lower mycophenolate mofetil drug exposure, possibly by interfering with the enterohepatic recirculation: A case series | Oral antibiotics lower mycophenolate mofetil drug exposure, possibly by interfering with the enterohepatic recirculation: A case series Abstract Abstract Mycophenolate mofetil has an important role as immunosuppressive agent in solid organ transplant recipients. Exposure to the active mycophenolic acid (MPA) can be mon... |
PMC11443321 | core_pubmed_pmc | Pharmacokinetic comparison of subcutaneously administered CT ‐ P13 (biosimilar of infliximab) via autoinjector and pre‐filled syringe in healthy participants | Pharmacokinetic comparison of subcutaneously administered CT ‐ P13 (biosimilar of infliximab) via autoinjector and pre‐filled syringe in healthy participants Abstract Abstract CT‐P13, a biosimilar of infliximab, is used to treat inflammatory diseases that arise from immune system complications, resulting in excessive a... |
PMC9743962 | core_pubmed_pmc | Zelquistinel Is an Orally Bioavailable Novel NMDA Receptor Allosteric Modulator That Exhibits Rapid and Sustained Antidepressant-Like Effects | Zelquistinel Is an Orally Bioavailable Novel NMDA Receptor Allosteric Modulator That Exhibits Rapid and Sustained Antidepressant-Like Effects Abstract Abstract Background The role of glutamatergic receptors in major depressive disorder continues to be of great interest for therapeutic development. Recent studies sugges... |
PMC10651645 | core_pubmed_pmc | Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open‐label, phase I study in healthy subjects | Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open‐label, phase I study in healthy subjects Abstract Abstract Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1 under investigation for the treatment of cancer, includ... |
PMC12771343 | core_pubmed_pmc | Pharmacokinetics and metabolism of siamenoside I in rats | Pharmacokinetics and metabolism of siamenoside I in rats Abstract The pharmacokinetics and metabolism of [ 14 C]-siamenoside I were studied following single oral doses of 5 mg/kg bodyweight with intact and bile duct-cannulated rats. Elimination of radioactivity was rapid and essentially complete by the end of the sampl... |
PMC2945087 | core_pubmed_pmc | Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock | Insufficient β-lactam concentrations in the early phase of severe sepsis and septic shock Abstract Introduction Altered pharmacokinetics (PK) in critically ill patients can result in insufficient serum β-lactam concentrations when standard dosages are administered. Previous studies on β-lactam PK have generally exclude... |
PMC4790523 | core_pubmed_pmc | Concentrated insulins: the new basal insulins | Concentrated insulins: the new basal insulins Abstract Introduction Insulin therapy plays a critical role in the treatment of type 1 and type 2 diabetes mellitus. However, there is still a need to find basal insulins with 24-hour coverage and reduced risk of hypoglycemia. Additionally, with increasing obesity and insul... |
PMC12028979 | core_pubmed_pmc | Filgotinib to Treat Acute Severe Refractory Ulcerative Colitis: A Case Report and Review of the Literature | Filgotinib to Treat Acute Severe Refractory Ulcerative Colitis: A Case Report and Review of the Literature Abstract Abstract Introduction Acute severe ulcerative colitis (ASUC) is a serious complication affecting 9%–15% of patients with UC within 3 months of diagnosis and up to 28% of patients during the course of the ... |
PMC8944503 | core_pubmed_pmc | Antimicrobial Random Peptide Mixtures Eradicate Acinetobacter baumannii Biofilms and Inhibit Mouse Models of Infection | Antimicrobial Random Peptide Mixtures Eradicate Acinetobacter baumannii Biofilms and Inhibit Mouse Models of Infection Abstract Antibiotic resistance is one of the greatest crises in human medicine. Increased incidents of antibiotic resistance are linked to clinical overuse and overreliance on antibiotics. Among the ES... |
PMC5844881 | core_pubmed_pmc | A Novel Role of Irbesartan in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats: Targeting DDAH/ADMA and EGFR/ERK Signaling | A Novel Role of Irbesartan in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats: Targeting DDAH/ADMA and EGFR/ERK Signaling Abstract The advent of angiotensin II type 1 receptor blockers (ARBs) as intriguing gastroprotective candidates and the superior pharmacokinetics and pharmacodynamics displayed ... |
PMC8419815 | core_pubmed_pmc | The praziquantel in preschoolers (PIP) trial: study protocol for a phase II PK/PD-driven randomised controlled trial of praziquantel in children under 4 years of age | The praziquantel in preschoolers (PIP) trial: study protocol for a phase II PK/PD-driven randomised controlled trial of praziquantel in children under 4 years of age Abstract Background Over 200 million individuals worldwide are infected with Schistosoma species, with over half of infections occurring in children. Many... |
PMC5346509 | core_pubmed_pmc | Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures | Experience and pharmacokinetics of Levetiracetam in Korean neonates with neonatal seizures Abstract Abstract Purpose The aims of this study were to evaluate the safety and pharmacokinetics of levetiracetam (LEV) in neonates with seizures and to establish a population pharmacokinetics (PPK) model by using the software N... |
PMC3480797 | core_pubmed_pmc | Effects of pravastatin on the pharmacokinetic parameters of nimodipine after oral and intravenous administration in rats: Possible role of CYP3A4 inhibition by pravastatin | Effects of pravastatin on the pharmacokinetic parameters of nimodipine after oral and intravenous administration in rats: Possible role of CYP3A4 inhibition by pravastatin Abstract Abstract Objective: The aim of this study was to investigate the effects of pravastatin on the pharmacokinetics of nimodipine in rats. Mate... |
PMC9898348 | core_pubmed_pmc | Bioactive compounds, pharmacological actions and pharmacokinetics of Cupressus sempervirens | Bioactive compounds, pharmacological actions and pharmacokinetics of Cupressus sempervirens Abstract Abstract The roles of plants and its products in all forms of life cannot be overemphasized. The medicinal products from plant are phytochemicals, drugs, food supplements, beauty products, etc. In ethnomedicine, leaves,... |
PMC8657875 | core_pubmed_pmc | Determination of CYP450 Expression Levels in the Human Small Intestine by Mass Spectrometry-Based Targeted Proteomics | Determination of CYP450 Expression Levels in the Human Small Intestine by Mass Spectrometry-Based Targeted Proteomics Abstract Abstract The human small intestine can be involved in the first-pass metabolism of drugs. Under this condition, members of the CYP450 superfamily are expected to contribute to drug presystemic ... |
PMC7878668 | core_pubmed_pmc | A Randomized Phase 1 Pharmacokinetic Study Comparing the Potential Biosimilar LRG201902 With Liraglutide (Victoza ® ) in Healthy Male Subjects | A Randomized Phase 1 Pharmacokinetic Study Comparing the Potential Biosimilar LRG201902 With Liraglutide (Victoza ® ) in Healthy Male Subjects Abstract Objective: Pharmacokinetic (PK) similarity between biosimilar candidate LRG201902 and European Union-sourced liraglutide reference product (Victoza ® ) was evaluated. S... |
PMC7897713 | core_pubmed_pmc | Safety, Tolerability, and Pharmacokinetics of Ibuprofenamine Hydrochloride Spray (NSAIDs), a New Drug for Rheumatoid Arthritis and Osteoarthritis, in Healthy Chinese Subjects | Safety, Tolerability, and Pharmacokinetics of Ibuprofenamine Hydrochloride Spray (NSAIDs), a New Drug for Rheumatoid Arthritis and Osteoarthritis, in Healthy Chinese Subjects Abstract Abstract Background Ibuprofenamine hydrochloride spray is novel transdermal nonsteroidal anti-inflammatory drugs (NSAIDs), under clinica... |
PMC12207764 | core_pubmed_pmc | A phase I, randomized, double-blind, parallel, single-dose pharmacokinetic study to evaluate the biosimilarity of KM118 (proposed pertuzumab biosimilar) with reference pertuzumab (Perjeta ® ) in healthy male subjects | A phase I, randomized, double-blind, parallel, single-dose pharmacokinetic study to evaluate the biosimilarity of KM118 (proposed pertuzumab biosimilar) with reference pertuzumab (Perjeta ® ) in healthy male subjects Abstract Abstract Objective KM118 is a biosimilar to pertuzumab (Perjeta ® ). This study aimed to prove... |
PMC4893096 | core_pubmed_pmc | Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an inadequate response to allopurinol | Lesinurad in combination with allopurinol: results of a phase 2, randomised, double-blind study in patients with gout with an inadequate response to allopurinol Abstract Abstract Objectives To assess the efficacy and tolerability of lesinurad, an oral selective uric acid reabsorption inhibitor, in combination with allo... |
PMC11529650 | core_pubmed_pmc | Clinical Risk Factors for High‐Dose Methotrexate‐Induced Oral Mucositis Following Individualized Dosing | Clinical Risk Factors for High‐Dose Methotrexate‐Induced Oral Mucositis Following Individualized Dosing Abstract ABSTRACT Background Oral mucositis affects about 20% of children undergoing high‐dose methotrexate (HDMTX) for acute lymphoblastic leukemia (ALL), despite existing management strategies. Personalized HDMTX d... |
PMC10261210 | core_pubmed_pmc | Phase 1 study of the pan-RAF inhibitor tovorafenib in patients with advanced solid tumors followed by dose expansion in patients with metastatic melanoma | Phase 1 study of the pan-RAF inhibitor tovorafenib in patients with advanced solid tumors followed by dose expansion in patients with metastatic melanoma Abstract Abstract Purpose Genomic alterations of BRAF and NRAS are oncogenic drivers in malignant melanoma and other solid tumors. Tovorafenib is an investigational, ... |
PMC10087559 | core_pubmed_pmc | Drug‐Drug Interactions With the Hepatitis B Virus Capsid Assembly Modulator JNJ‐56136379 (Bersacapavir) | Drug‐Drug Interactions With the Hepatitis B Virus Capsid Assembly Modulator JNJ‐56136379 (Bersacapavir) Abstract Abstract The capsid assembly modulator JNJ‐56136379 (bersacapavir) disrupts hepatitis B virus replication. It is metabolized via cytochrome P450 (CYP) 3A, but little is known about the drug‐drug interactions... |
PMC11678027 | core_pubmed_pmc | In Vitro Dynamic Model Evaluation of Meropenem Alone and in Combination with Avibactam Against Carbapenemase-Producing Klebsiella pneumoniae | In Vitro Dynamic Model Evaluation of Meropenem Alone and in Combination with Avibactam Against Carbapenemase-Producing Klebsiella pneumoniae Abstract Abstract Background: A potential strategy to maintain the efficacy of carbapenems against carbapenemase-producing Klebsiella pneumoniae (CPKP) is their combination with c... |
PMC9897050 | core_pubmed_pmc | Safety, tolerability, and pharmacokinetics of single and multiple ascending Oral doses of DA ‐8010 in healthy subjects: First‐in‐human phase I study | Safety, tolerability, and pharmacokinetics of single and multiple ascending Oral doses of DA ‐8010 in healthy subjects: First‐in‐human phase I study Abstract Abstract This study assessed the safety, tolerability, and pharmacokinetics of single and multiple oral doses of DA‐8010, a muscarinic M 3 receptor antagonist, in... |
PMC11136851 | core_pubmed_pmc | Longitudinal modeling of efficacy response in patients with lupus nephritis receiving belimumab | Longitudinal modeling of efficacy response in patients with lupus nephritis receiving belimumab Abstract Abstract Belimumab was approved for active lupus nephritis (LN) in adults in the European Union and patients ≥ 5 years of age in the USA based on a Phase 3, double-blind, placebo-controlled, 104-week study. The stud... |
PMC11450921 | core_pubmed_pmc | Racial, ethnic and regional differences in the effect of sodium–glucose co-transporter 2 inhibitors and glucagon-like peptide 1 receptor agonists on cardiovascular and renal outcomes: a systematic review and meta-analysis of cardiovascular outcome trials | Racial, ethnic and regional differences in the effect of sodium–glucose co-transporter 2 inhibitors and glucagon-like peptide 1 receptor agonists on cardiovascular and renal outcomes: a systematic review and meta-analysis of cardiovascular outcome trials Abstract Objectives The cardiorenal protective effects of sodium–... |
PMC6394511 | core_pubmed_pmc | Modelling of oscillatory cortisol response in horses using a Bayesian population approach for evaluation of dexamethasone suppression test protocols | Modelling of oscillatory cortisol response in horses using a Bayesian population approach for evaluation of dexamethasone suppression test protocols Abstract Abstract Cortisol is a steroid hormone relevant to immune function in horses and other species and shows a circadian rhythm. The glucocorticoid dexamethasone supp... |
PMC11772350 | core_pubmed_pmc | Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effect | Hydroxysafflor yellow A: a natural pigment with potential anticancer therapeutic effect Abstract Abstract Hydroxysafflor yellow A (HSYA), a natural pigment with a chalcone structure extracted from Carthamus tinctorius L. (Safflower), has been widely proven to have good efficacy on cardiovascular diseases, atheroscleros... |
PMC12164861 | core_pubmed_pmc | Impact of Fungal Co-Infection on Teicoplanin Plasma Trough Concentration in Critically Ill Adults: A Novel Consideration for Dose Adjustment | Impact of Fungal Co-Infection on Teicoplanin Plasma Trough Concentration in Critically Ill Adults: A Novel Consideration for Dose Adjustment Abstract Objective The pathophysiology and disease status of critically ill patients have a significant impact on the pharmacokinetics/pharmacodynamics (PK/PD) of antimicrobial ag... |
PMC8093168 | core_pubmed_pmc | Assessing Treatment Effects with Pharmacometric Models: A New Method that Addresses Problems with Standard Assessments | Assessing Treatment Effects with Pharmacometric Models: A New Method that Addresses Problems with Standard Assessments Abstract Longitudinal pharmacometric models offer many advantages in the analysis of clinical trial data, but potentially inflated type I error and biased drug effect estimates, as a consequence of mod... |
PMC12439280 | core_pubmed_pmc | Mechanism‐Based Modeling Approaches to Quantify the Effect of Immunogenicity on the Pharmacokinetics of Therapeutic Proteins in Drug Development | Mechanism‐Based Modeling Approaches to Quantify the Effect of Immunogenicity on the Pharmacokinetics of Therapeutic Proteins in Drug Development Abstract ABSTRACT Therapeutic protein administration in both preclinical and clinical studies can result in the formation of anti‐drug antibodies against the therapeutic prote... |
PMC9662200 | core_pubmed_pmc | Population pharmacokinetics modeling and exposure‐response analyses of cemiplimab in patients with recurrent or metastatic cervical cancer | Population pharmacokinetics modeling and exposure‐response analyses of cemiplimab in patients with recurrent or metastatic cervical cancer Abstract Abstract A population pharmacokinetic (PopPK) model was previously developed for cemiplimab in patients with solid tumors, including advanced cutaneous squamous cell carcin... |
PMC8416863 | core_pubmed_pmc | Population Pharmacokinetics and Pharmacodynamics of Once-Daily Growth Hormone Norditropin ® in Children and Adults | Population Pharmacokinetics and Pharmacodynamics of Once-Daily Growth Hormone Norditropin ® in Children and Adults Abstract Abstract Background and Objective Once-daily injectable recombinant human growth hormone (GH) formulations (e.g. Norditropin ® ; Novo Nordisk A/S) are used to treat GH deficiency in children and a... |
PMC10015254 | core_pubmed_pmc | Comparative antihyperglycemic, analgesic and anti-inflammatory potential of ethanolic aerial root extracts of Ceriops decandra and Ceriops tagal : Supported by molecular docking and ADMET analysis | Comparative antihyperglycemic, analgesic and anti-inflammatory potential of ethanolic aerial root extracts of Ceriops decandra and Ceriops tagal : Supported by molecular docking and ADMET analysis Abstract Ceriops decandra (Griff.) (CD) and Ceriops tagal (Perr.) (CT) are two mangrove plants of the Sundarbans distribute... |
PMC9845125 | core_pubmed_pmc | Fabrication and characterization of orodispersible films loaded with solid dispersion to enhance Rosuvastatin calcium bioavailability | Fabrication and characterization of orodispersible films loaded with solid dispersion to enhance Rosuvastatin calcium bioavailability Abstract Abstract The present study was aimed to formulate and evaluate fast dissolving oral film of Rosuvastatin calcium to improve its bioavailability in comparison to typical solid or... |
PMC12528282 | core_pubmed_pmc | Scoping review of the role of pharmacometrics in model-informed drug development | Scoping review of the role of pharmacometrics in model-informed drug development Abstract Abstract Model-informed drug development (MIDD) is a framework that utilizes quantitative modeling and simulation methods to integrate nonclinical and clinical data, as well as prior knowledge, to inform drug development and regul... |
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