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PMC7604696 | core_pubmed_pmc | Effect of gastric acid‐reducing agents on the pharmacokinetics and efficacy of lemborexant | Effect of gastric acid‐reducing agents on the pharmacokinetics and efficacy of lemborexant Abstract Abstract Lemborexant is a dual orexin receptor antagonist approved for treating insomnia. As the solubility of lemborexant is pH‐sensitive, the impact of the gastric acid‐reducing agent (ARA), famotidine, on lemborexant ... |
PMC9311841 | core_pubmed_pmc | Pharmacokinetics and Safety of Doripenem in Healthy Chinese Subjects and Monte Carlo Dosing Simulations | Pharmacokinetics and Safety of Doripenem in Healthy Chinese Subjects and Monte Carlo Dosing Simulations Abstract The aim of this study was to investigate the pharmacokinetics (PK) of doripenem in healthy Chinese subjects and evaluate the optimal dosage regimens of doripenem. A randomized, single-dose, three-period, sel... |
PMC9926328 | core_pubmed_pmc | Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial | Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial Abstract Key Points Question Are there acute pharmacokinetic or pharmacodynamic differences between oral ingestio... |
PMC9568796 | core_pubmed_pmc | Participation of Older Adults in Clinical Trials for New Drug Applications and Biologics License Applications From 2010 Through 2019 | Participation of Older Adults in Clinical Trials for New Drug Applications and Biologics License Applications From 2010 Through 2019 Abstract Key Points Question Are older adults adequately represented in clinical trials for new drug evaluation? Findings In this cross-sectional study, adults in the oldest age groups ab... |
PMC12796554 | core_pubmed_pmc | Metformin in the Horse: Pharmacokinetics and Detection Times Using Monte Carlo Simulations | Metformin in the Horse: Pharmacokinetics and Detection Times Using Monte Carlo Simulations Abstract ABSTRACT The racehorse industry has strict regulations regarding the detection of prohibited substances in horses. Metformin, a diabetes medication, is a prohibited substance that has been reported in post‐race blood and... |
PMC12198911 | core_pubmed_pmc | Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Afimetoran, a Toll‐Like Receptor 7 and 8 Inhibitor, in Patients With Cutaneous Lupus Erythematosus: A Phase 1b Randomized, Double‐Blind, Placebo‐Controlled Study | Safety, Tolerability, Efficacy, Pharmacokinetics, and Pharmacodynamics of Afimetoran, a Toll‐Like Receptor 7 and 8 Inhibitor, in Patients With Cutaneous Lupus Erythematosus: A Phase 1b Randomized, Double‐Blind, Placebo‐Controlled Study Abstract Abstract Objective There is an unmet need for safe and effective oral treat... |
PMC5481270 | core_pubmed_pmc | Antiparasitic Sesquiterpenes from the Cameroonian Spice Scleria striatinux and Preliminary In Vitro and In Silico DMPK Assessment | Antiparasitic Sesquiterpenes from the Cameroonian Spice Scleria striatinux and Preliminary In Vitro and In Silico DMPK Assessment Abstract Abstract Abstract The antiparasitic activity and preliminary in vitro and in silico drug metabolism and pharmacokinetic (DMPK) assessment of six isomeric sesquiterpenes ( 1 – 6 ), i... |
PMC10568461 | core_pubmed_pmc | A pilot study of cerebral metabolism and serotonin 5-HT 2A receptor occupancy in rats treated with the psychedelic tryptamine DMT in conjunction with the MAO inhibitor harmine | A pilot study of cerebral metabolism and serotonin 5-HT 2A receptor occupancy in rats treated with the psychedelic tryptamine DMT in conjunction with the MAO inhibitor harmine Abstract Rationale: The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are often attributed to agonism ... |
PMC11768591 | core_pubmed_pmc | Development of a Novel Co-Amorphous Curcumin and L-Arginine (1:2): Structural Characterization, Biological Activity and Pharmacokinetics | Development of a Novel Co-Amorphous Curcumin and L-Arginine (1:2): Structural Characterization, Biological Activity and Pharmacokinetics Abstract Abstract Background: Curcumin appears to be well tolerated and effective for managing chronic inflammatory pain, but its poor oral bioavailability has been a hurdle in its us... |
PMC3862718 | core_pubmed_pmc | First-in-Human Phase I Study of PRS-050 (Angiocal), an Anticalin Targeting and Antagonizing VEGF-A, in Patients with Advanced Solid Tumors | First-in-Human Phase I Study of PRS-050 (Angiocal), an Anticalin Targeting and Antagonizing VEGF-A, in Patients with Advanced Solid Tumors Abstract Background To report the nonrandomized first-in-human phase I trial of PRS-050, a novel, rationally engineered Anticalin based on human tear lipocalin that targets and anta... |
PMC11282650 | core_pubmed_pmc | Evaluation of the landscape of pharmacodynamic biomarkers in Niemann-Pick Disease Type C (NPC) | Evaluation of the landscape of pharmacodynamic biomarkers in Niemann-Pick Disease Type C (NPC) Abstract Abstract Niemann-Pick disease type C (NPC) is an autosomal recessive, progressive disorder resulting from variants in NPC1 or NPC2 that leads to the accumulation of cholesterol and other lipids in late endosomes and ... |
PMC6584252 | core_pubmed_pmc | Population Pharmacokinetic Modeling of Benralizumab in Adult and Adolescent Patients with Asthma | Population Pharmacokinetic Modeling of Benralizumab in Adult and Adolescent Patients with Asthma Abstract Abstract Introduction Benralizumab, an interleukin-5 receptor alpha–directed cytolytic anti-eosinophil monoclonal antibody, was recently approved as add-on maintenance treatment for patients aged 12 years and older... |
PMC6132870 | core_pubmed_pmc | Comparison of levetiracetam with phenytoin for the prevention of intravenous busulfan-induced seizures in hematopoietic cell transplantation recipients | Comparison of levetiracetam with phenytoin for the prevention of intravenous busulfan-induced seizures in hematopoietic cell transplantation recipients Abstract Abstract Purpose Busulfan is used as a conditioning regimen for hematopoietic stem cell transplantation and is known to cause seizures as a side effect. As var... |
PMC8069917 | core_pubmed_pmc | Stability of Antimicrobial Drug Molecules in Different Gravitational and Radiation Conditions in View of Applications during Outer Space Missions | Stability of Antimicrobial Drug Molecules in Different Gravitational and Radiation Conditions in View of Applications during Outer Space Missions Abstract Abstract The evolution of different antimicrobial drugs in terrestrial, microgravity and hypergravity conditions is presented within this review, in connection with ... |
PMC9382104 | core_pubmed_pmc | Effectiveness and safety of morinidazole in the treatment of pelvic inflammatory disease: A multicenter, prospective, open-label phase IV trial | Effectiveness and safety of morinidazole in the treatment of pelvic inflammatory disease: A multicenter, prospective, open-label phase IV trial Abstract Abstract Background Antimicrobial resistance to metronidazole has emerged after several decades of worldwide use of the drug. The purpose of this study was to evaluate... |
PMC8120430 | core_pubmed_pmc | Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: A Review | Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: A Review Abstract Abstract Curcuma species (family: Zingiberaceae) are widely utilized in traditional medicine to treat diverse immune-related disorders. There have been many scientific studies on their immunomodulating effects to... |
PMC8453752 | core_pubmed_pmc | Population Pharmacokinetic Modeling and Simulations of Imipenem in Burn Patients With and Without Continuous Venovenous Hemofiltration in the Military Health System | Population Pharmacokinetic Modeling and Simulations of Imipenem in Burn Patients With and Without Continuous Venovenous Hemofiltration in the Military Health System Abstract Abstract Continuous venovenous hemofiltration (CVVH) is a life‐sustaining procedure in patients with severe burns and acute kidney injury. Physiol... |
PMC5745716 | core_pubmed_pmc | Genistein Exposure Interferes with Pharmacokinetics of Celecoxib in SD Male Rats by UPLC-MS/MS | Genistein Exposure Interferes with Pharmacokinetics of Celecoxib in SD Male Rats by UPLC-MS/MS Abstract Objective To discuss the effects of genistein on the metabolism of celecoxib in vitro and in vivo. Method In vitro, the effects of genistein on the metabolism of celecoxib were studied using rat and human liver micro... |
PMC7384935 | core_pubmed_pmc | A Year-Long Extended Release Nanoformulated Cabotegravir Prodrug | A Year-Long Extended Release Nanoformulated Cabotegravir Prodrug Abstract Long-acting cabotegravir (CAB) extends antiretroviral drug (ARV) administration from daily to monthly. However, dosing volumes, injection site reactions, and health care oversight are obstacles towards broad usage. The creation of poloxamer-coate... |
PMC8531271 | core_pubmed_pmc | Pharmacokinetics and Drug-Drug Interactions of Abacavir and Lamuvudine Co-administered With Antituberculosis Drugs in HIV-Positive Children Treated for Multidrug-Resistant Tuberculosis | Pharmacokinetics and Drug-Drug Interactions of Abacavir and Lamuvudine Co-administered With Antituberculosis Drugs in HIV-Positive Children Treated for Multidrug-Resistant Tuberculosis Abstract Abstract Given the high prevalence of multidrug-resistant (MDR)-TB in high HIV burden settings, it is important to identify po... |
PMC10509835 | core_pubmed_pmc | Rapid increases in epinephrine concentration following presumed intra–blood vessel administration via epinephrine autoinjector | Rapid increases in epinephrine concentration following presumed intra–blood vessel administration via epinephrine autoinjector Abstract Abstract While epinephrine autoinjectors have been the standard of care for the out-of-hospital treatment of anaphylaxis, their use has been associated with potential cardiovascular ri... |
PMC8005094 | core_pubmed_pmc | PET Diagnostic Molecules Utilizing Multimeric Cyclic RGD Peptide Analogs for Imaging Integrin α v β 3 Receptors | PET Diagnostic Molecules Utilizing Multimeric Cyclic RGD Peptide Analogs for Imaging Integrin α v β 3 Receptors Abstract Abstract Multimeric ligands consisting of multiple pharmacophores connected to a single backbone have been widely investigated for diagnostic and therapeutic applications. In this review, we summariz... |
PMC11504261 | core_pubmed_pmc | Evaluation of the Efficacy of Intravenous Push and Intravenous Piggyback Ceftriaxone in Critically Ill Patients | Evaluation of the Efficacy of Intravenous Push and Intravenous Piggyback Ceftriaxone in Critically Ill Patients Abstract Abstract Background/Objective : Intravenous fluid shortages have led to fluid-sparing measures such as intravenous push (IVP) administration of antibiotics. This study aimed to compare the safety and... |
PMC7760646 | core_pubmed_pmc | Semi-Mechanistic Pharmacokinetic Model to Guide the Dose Selection of Nimotuzumab in Patients with Autosomal Dominant Polycystic Kidney Disease | Semi-Mechanistic Pharmacokinetic Model to Guide the Dose Selection of Nimotuzumab in Patients with Autosomal Dominant Polycystic Kidney Disease Abstract Abstract Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disease characterized by an overexpression of epidermal growth factor receptor (EGFR). Nimot... |
PMC10435398 | core_pubmed_pmc | Excessive vincristine exposure in a child being treated for acute lymphoblastic leukaemia with underlying Dubin–Johnson syndrome: a case report | Excessive vincristine exposure in a child being treated for acute lymphoblastic leukaemia with underlying Dubin–Johnson syndrome: a case report Abstract Abstract Background Dubin–Johnson syndrome is a rare benign autosomal recessive condition that causes an isolated increase of conjugated bilirubin in the serum. Impair... |
PMC11598743 | core_pubmed_pmc | First‐in‐Human Study of BAT4406F, an ADCC‐Enhanced Fully Humanized Anti‐CD20 Monoclonal Antibody in Patients With Neuromyelitis Optica Spectrum Disorders | First‐in‐Human Study of BAT4406F, an ADCC‐Enhanced Fully Humanized Anti‐CD20 Monoclonal Antibody in Patients With Neuromyelitis Optica Spectrum Disorders Abstract ABSTRACT Introduction Neuromyelitis optica spectrum disorder (NMOSD) is a rare debilitating autoimmune disease of the central nervous system (CNS). This is t... |
PMC6100507 | core_pubmed_pmc | Ultra-Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS)-Based Pharmacokinetics and Tissue Distribution Study of Koumine and the Detoxification Mechanism of Glycyrrhiza uralensis Fisch on Gelsemium elegans Benth. | Ultra-Liquid Chromatography Tandem Mass Spectrometry (UPLC-MS/MS)-Based Pharmacokinetics and Tissue Distribution Study of Koumine and the Detoxification Mechanism of Glycyrrhiza uralensis Fisch on Gelsemium elegans Benth. Abstract Abstract Gelsemium elegans Benth. ( G. elegans ), which is a famous Chinese folk medicine... |
PMC11620666 | core_pubmed_pmc | Pharmacokinetic evaluation of single-dose migalastat in non-Fabry disease subjects with ESRD receiving dialysis treatment, and use of modeling to select dose regimens in Fabry disease subjects with ESRD receiving dialysis treatment | Pharmacokinetic evaluation of single-dose migalastat in non-Fabry disease subjects with ESRD receiving dialysis treatment, and use of modeling to select dose regimens in Fabry disease subjects with ESRD receiving dialysis treatment Abstract Background Fabry disease (FD) is an X-linked lysosomal disorder leading to mult... |
PMC12640043 | core_pubmed_pmc | Eloralintide (LY3841136), a novel amylin receptor agonist for the treatment of obesity: From discovery to clinical proof of concept | Eloralintide (LY3841136), a novel amylin receptor agonist for the treatment of obesity: From discovery to clinical proof of concept Abstract Objectives Eloralintide (LY3841136), a novel amylin analog, was evaluated in translational studies to characterize its therapeutic potential for treating obesity. Methods In vitro... |
PMC6600414 | core_pubmed_pmc | Pharmacokinetics and Tissue Distribution of a Novel Bis-Chelated Gold(I) Diphosphine Compound, Bis(2,3-bis(tert-butylmethylphosphino)Quinoxaline)Aurate(I), in Rats | Pharmacokinetics and Tissue Distribution of a Novel Bis-Chelated Gold(I) Diphosphine Compound, Bis(2,3-bis(tert-butylmethylphosphino)Quinoxaline)Aurate(I), in Rats Abstract Abstract GC20, a novel soluble bis-chelated gold(I)−diphosphine compound, has been reported as a promising anticancer candidate. Assessing the phar... |
PMC3016232 | core_pubmed_pmc | Effects of methimazole on the elimination of irinotecan | Effects of methimazole on the elimination of irinotecan Abstract Purpose To study the possible pharmacokinetic and pharmacodynamic interactions between irinotecan and methimazole. Methods A patient treated for colorectal cancer with single agent irinotecan received methimazole co-medication for Graves’ disease. Irinote... |
PMC5217871 | core_pubmed_pmc | Single and multiple dose pharmacokinetics and pharmacodynamics of omarigliptin, a novel, once‐weekly dipeptidyl peptidase‐4 inhibitor, in healthy Japanese men | Single and multiple dose pharmacokinetics and pharmacodynamics of omarigliptin, a novel, once‐weekly dipeptidyl peptidase‐4 inhibitor, in healthy Japanese men Abstract Abstract Aims/Introduction Omarigliptin is a novel, potent, long‐acting oral dipeptidyl peptidase‐4 inhibitor being developed as a once‐weekly (q.w.) tr... |
PMC3112458 | core_pubmed_pmc | Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis | Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis Abstract Abstract The case of a 32-year-old Caucasian female with multi-drug resistant HIV-1 subtype B infection treated with a salvage regimen including maraviroc, raltegravir, etravirine and unboosted saquinavir... |
PMC9692523 | core_pubmed_pmc | Exposure to (Poly)phenol Metabolites after a Fruit and Vegetable Supplement Intake: A Double-Blind, Cross-Over, Randomized Trial | Exposure to (Poly)phenol Metabolites after a Fruit and Vegetable Supplement Intake: A Double-Blind, Cross-Over, Randomized Trial Abstract Dietary (poly)phenol intake derived from the daily consumption of five portions of fruits and vegetables could protect against the development of non-communicable diseases. However, ... |
PMC9278710 | core_pubmed_pmc | Pharmacokinetics of Budesonide Oral Suspension in Children and Adolescents With Eosinophilic Esophagitis | Pharmacokinetics of Budesonide Oral Suspension in Children and Adolescents With Eosinophilic Esophagitis Abstract Abstract The pharmacokinetic (PK) profile of budesonide oral suspension (BOS) was evaluated during a phase 2, randomized, double-blind, placebo-controlled, dose-ranging study in pediatric patients with eosi... |
PMC8507417 | core_pubmed_pmc | Spotlight on Trastuzumab Deruxtecan (DS-8201,T-DXd) for HER2 Mutation Positive Non-Small Cell Lung Cancer | Spotlight on Trastuzumab Deruxtecan (DS-8201,T-DXd) for HER2 Mutation Positive Non-Small Cell Lung Cancer Abstract Abstract Human epidermal growth factor receptor 2 ( HER2 ) is a proto-oncogene that, when mutated or overexpressed, plays an important role in oncogenesis. The landscape of HER2 -positive breast cancer has... |
PMC4593207 | core_pubmed_pmc | Once-daily dose regimen of ribavirin is interchangeable with a twice-daily dose regimen: randomized open clinical trial | Once-daily dose regimen of ribavirin is interchangeable with a twice-daily dose regimen: randomized open clinical trial Abstract Background The combination of ribavirin (RBV) and pegylated interferon (PEG-IFN) is effective in the treatment of chronic hepatitis C infection. Reducing the frequency of RBV intake from twic... |
PMC4597189 | core_pubmed_pmc | Hetero-modification of TRAIL trimer for improved drug delivery and in vivo antitumor activities | Hetero-modification of TRAIL trimer for improved drug delivery and in vivo antitumor activities Abstract Abstract Poor pharmacokinetics and resistance within some tumor cell lines have been the major obstacles during the preclinical or clinical application of TRAIL (tumor-necrosis-factor (TNF)-related apoptosis-inducin... |
PMC6354023 | core_pubmed_pmc | A phase I study of the HDM2 antagonist SAR405838 combined with the MEK inhibitor pimasertib in patients with advanced solid tumours | A phase I study of the HDM2 antagonist SAR405838 combined with the MEK inhibitor pimasertib in patients with advanced solid tumours Abstract Abstract Background This phase I, open-label, dose-escalation study evaluated the safety, pharmacokinetics and pharmacodynamics of combination therapy with the HDM2 inhibitor SAR4... |
PMC9328201 | core_pubmed_pmc | Why we should sample sparsely and aim for a higher target: Lessons from model‐based therapeutic drug monitoring of vancomycin in intensive care patients | Why we should sample sparsely and aim for a higher target: Lessons from model‐based therapeutic drug monitoring of vancomycin in intensive care patients Abstract Aims To explore the optimal data sampling scheme and the pharmacokinetic (PK) target exposure on which dose computation is based in the model‐based therapeuti... |
PMC9986696 | core_pubmed_pmc | Interstitial washdown during crystalloid fluid loading in graded hypovolemia –A retrospective analysis in volunteers | Interstitial washdown during crystalloid fluid loading in graded hypovolemia –A retrospective analysis in volunteers Abstract Abstract BACKGROUND: “Interstitial washdown” is an edema-preventing mechanism that implies a greater redistribution of interstitial albumin occurs whenever the capillary filtration is increased.... |
PMC9577195 | core_pubmed_pmc | Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate | Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate Abstract Glytrexate, developed by our team, as a novel multitarget folate antagonist, has inhibitory effects on a variety of cancer cell types, especially KB tumor cells (IC 50 0.078 nM), and thus has antit... |
PMC7958597 | core_pubmed_pmc | In Vivo Biodistribution and Efficacy Evaluation of NeoB, A Radiotracer Targeted to GRPR, in Mice Bearing Gastrointestinal Stromal Tumor | In Vivo Biodistribution and Efficacy Evaluation of NeoB, A Radiotracer Targeted to GRPR, in Mice Bearing Gastrointestinal Stromal Tumor Abstract Simple Summary NeoB is undergoing evaluation as a novel theragnostic agent—that is, that it can be employed either for the diagnosis of tumor expressing gastrin-releasing pept... |
PMC7577144 | core_pubmed_pmc | An Open-Label Study of the Impact of Hepatic Impairment on the Pharmacokinetics and Safety of Single Oral and Intravenous Doses of Omadacycline | An Open-Label Study of the Impact of Hepatic Impairment on the Pharmacokinetics and Safety of Single Oral and Intravenous Doses of Omadacycline Abstract Omadacycline is a once-daily oral or intravenous (i.v.) aminomethylcycline antibiotic approved in the United States for the treatment of community-acquired bacterial p... |
PMC11217182 | core_pubmed_pmc | A web-based scoping review assessing the influence of smoking and smoking cessation on antidiabetic drug meabolism: implications for medication efficacy | A web-based scoping review assessing the influence of smoking and smoking cessation on antidiabetic drug meabolism: implications for medication efficacy Abstract Abstract Currently 1.3 billion individuals globally engage in smoking, leading to significant morbidity and mortality, particularly among diabetic patients. T... |
PMC7354465 | core_pubmed_pmc | Toxicokinetics of Hydrolyzed Fumonisin B 1 after Single Oral or Intravenous Bolus to Broiler Chickens Fed a Control or a Fumonisins-Contaminated Diet | Toxicokinetics of Hydrolyzed Fumonisin B 1 after Single Oral or Intravenous Bolus to Broiler Chickens Fed a Control or a Fumonisins-Contaminated Diet Abstract Abstract The toxicokinetics (TK) of hydrolyzed fumonisin B 1 (HFB 1 ) were evaluated in 16 broiler chickens after being fed either a control or a fumonisins-cont... |
PMC9571303 | core_pubmed_pmc | Development of Clinical Weekly-Dose Teriparatide Acetate Encapsulated Dissolving Microneedle Patch for Efficient Treatment of Osteoporosis | Development of Clinical Weekly-Dose Teriparatide Acetate Encapsulated Dissolving Microneedle Patch for Efficient Treatment of Osteoporosis Abstract Abstract Teriparatide acetate (TA), which directly promotes bone formation, is subcutaneously injected to treat osteoporosis. In this study, TA with a once-weekly administr... |
PMC12616876 | core_pubmed_pmc | Pharmacokinetic‐Pharmacodynamic Model of Paclitaxel‐Induced Peripheral Neuropathy | Pharmacokinetic‐Pharmacodynamic Model of Paclitaxel‐Induced Peripheral Neuropathy Abstract ABSTRACT Chemotherapy‐induced peripheral neuropathy (CIPN) is a common neurological toxicity of paclitaxel treatment in patients with cancer that can cause irreversible reductions in function and quality of life. CIPN risk is hig... |
PMC12310894 | core_pubmed_pmc | A phase I study of liposomal Irinotecan (ONIVYDE®) in combination with TAS-102 (LONSURF®) in refractory solid tumors | A phase I study of liposomal Irinotecan (ONIVYDE®) in combination with TAS-102 (LONSURF®) in refractory solid tumors Abstract Abstract Onivyde, a liposome-encapsulated irinotecan, is used for advanced pancreatic, while TAS-102 (trifluridine/tipiracil) is indicated for metastatic colorectal and gastric cancers. This stu... |
PMC11278387 | core_pubmed_pmc | Population pharmacokinetics of meropenem in critically ill patients | Population pharmacokinetics of meropenem in critically ill patients Abstract Abstract Objective The pharmacokinetics of meropenem are significantly altered in critically ill patients. A population pharmacokinetic study was designed to estimate typical values of meropenem clearance in critically ill patients and evaluat... |
PMC9021014 | core_pubmed_pmc | Therapeutic drug monitoring of cefepime in a non-critically ill population: retrospective assessment and potential role for model-based dosing | Therapeutic drug monitoring of cefepime in a non-critically ill population: retrospective assessment and potential role for model-based dosing Abstract Abstract Objectives To describe the therapeutic drug monitoring (TDM) of cefepime in non-critically ill adults and compare four different ways of dosing: conventional t... |
PMC7955357 | core_pubmed_pmc | Efficacy and Safety of Direct Oral Anticoagulants for Atrial Fibrillation Across Body Mass Index Categories | Efficacy and Safety of Direct Oral Anticoagulants for Atrial Fibrillation Across Body Mass Index Categories Abstract Background Direct‐acting oral anticoagulants are now the preferred method of anticoagulation in patients with atrial fibrillation. Limited data on efficacy and safety of these fixed‐dose regimens are ava... |
PMC4357615 | core_pubmed_pmc | Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits | Development and optimization of carvedilol orodispersible tablets: enhancement of pharmacokinetic parameters in rabbits Abstract Background Carvedilol (CVD) is used for the treatment of essential hypertension, heart failure, and systolic dysfunction after myocardial infarction. Due to its lower aqueous solubility and e... |
PMC11965454 | core_pubmed_pmc | Simultaneous determination of lesinurad and co-administered drugs used in management of gout comorbidities to uncover potential pharmacokinetic interaction in rat plasma | Simultaneous determination of lesinurad and co-administered drugs used in management of gout comorbidities to uncover potential pharmacokinetic interaction in rat plasma Abstract Abstract Gout is one of the most prevalent forms of arthritis that is usually accompanied by other comorbidities. For this reason, multiple d... |
PMC11291171 | core_pubmed_pmc | Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier | Proteomic Profiling Reveals Age-Related Changes in Transporter Proteins in the Human Blood-Brain Barrier Abstract Abstract The Blood-Brain Barrier (BBB) is a crucial, selective barrier that regulates the entry of molecules including nutrients, environmental toxins, and therapeutic medications into the brain. This funct... |
PMC3020290 | core_pubmed_pmc | Feedback modeling of non-esterified fatty acids in rats after nicotinic acid infusions | Feedback modeling of non-esterified fatty acids in rats after nicotinic acid infusions Abstract Abstract A feedback model was developed to describe the tolerance and oscillatory rebound seen in non-esterified fatty acid (NEFA) plasma concentrations following intravenous infusions of nicotinic acid (NiAc) to male Spragu... |
PMC9340410 | core_pubmed_pmc | Effect of inhaled budesonide/formoterol fumarate dihydrate delivered via two different devices on lung function in patients with COPD and low peak inspiratory flow | Effect of inhaled budesonide/formoterol fumarate dihydrate delivered via two different devices on lung function in patients with COPD and low peak inspiratory flow Abstract Background and aims: Low peak inspiratory flow (PIF) is common following severe exacerbations of chronic obstructive pulmonary disease (COPD). Pati... |
PMC11728834 | core_pubmed_pmc | Model-Based Dose Selection of a Sphingosine-1-Phosphate Modulator, Etrasimod, in Patients with Various Degrees of Hepatic Impairment | Model-Based Dose Selection of a Sphingosine-1-Phosphate Modulator, Etrasimod, in Patients with Various Degrees of Hepatic Impairment Abstract Abstract Background/Objectives: Etrasimod is a newly FDA-approved Sphingosine-1-Phosphate modulator indicated for moderate and severe ulcerative colitis. It is extensively metabo... |
PMC5535747 | core_pubmed_pmc | Evidence for Tissue Toxicity in BALB/c Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate | Evidence for Tissue Toxicity in BALB/c Exposed to a Long-Term Treatment with Oxiranes Compared to Meglumine Antimoniate Abstract Abstract Leishmaniasis remains a serious public health problem in developing countries without effective control, whether by vaccination or chemotherapy. Part of the failure of leishmaniasis ... |
PMC8453567 | core_pubmed_pmc | Napabucasin Drug‐Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers | Napabucasin Drug‐Drug Interaction Potential, Safety, Tolerability, and Pharmacokinetics Following Oral Dosing in Healthy Adult Volunteers Abstract Abstract Napabucasin is an orally administered reactive oxygen species generator that is bioactivated by the intracellular antioxidant nicotinamide adenine dinucleotide phos... |
PMC5215575 | core_pubmed_pmc | Phase 3, open‐label, randomized study of the pharmacokinetics, efficacy and safety of ixekizumab following subcutaneous administration using a prefilled syringe or an autoinjector in patients with moderate‐to‐severe plaque psoriasis ( UNCOVER ‐A) | Phase 3, open‐label, randomized study of the pharmacokinetics, efficacy and safety of ixekizumab following subcutaneous administration using a prefilled syringe or an autoinjector in patients with moderate‐to‐severe plaque psoriasis ( UNCOVER ‐A) Abstract Abstract Background The efficacy of ixekizumab, an anti‐interleu... |
PMC11749533 | core_pubmed_pmc | Micronutrient dose response (MiNDR) study among women of reproductive age and pregnant women in rural Bangladesh: study protocol for double-blind, randomised, controlled trials | Micronutrient dose response (MiNDR) study among women of reproductive age and pregnant women in rural Bangladesh: study protocol for double-blind, randomised, controlled trials Abstract Abstract Introduction Optimising the micronutrient status of women before and during reproduction confers benefits to them and their o... |
PMC4681141 | core_pubmed_pmc | Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model | Antiplasmodial activity, in vivo pharmacokinetics and anti-malarial efficacy evaluation of hydroxypyridinone hybrids in a mouse model Abstract Background During the erythrocytic stage in humans, malaria parasites digest haemoglobin of the host cell, and the toxic haem moiety crystallizes into haemozoin. Chloroquine act... |
PMC5069307 | core_pubmed_pmc | A Semi-Physiological Population Model to Quantify the Effect of Hematocrit on Everolimus Pharmacokinetics and Pharmacodynamics in Cancer Patients | A Semi-Physiological Population Model to Quantify the Effect of Hematocrit on Everolimus Pharmacokinetics and Pharmacodynamics in Cancer Patients Abstract Abstract Introduction and Objective Everolimus (a drug from the class of mammalian target of rapamycin [mTOR] inhibitors) is associated with frequent toxicity-relate... |
PMC10260260 | core_pubmed_pmc | The anti-SARS-CoV-2 activity of novel 9, 10-dihydrophenanthrene derivatives: an insight into molecular docking, ADMET analysis, and molecular dynamics simulation | The anti-SARS-CoV-2 activity of novel 9, 10-dihydrophenanthrene derivatives: an insight into molecular docking, ADMET analysis, and molecular dynamics simulation Abstract Abstract Originating in Wuhan, the COVID-19 pandemic wave has had a profound impact on the global healthcare system. In this study, we used a 2D QSAR... |
PMC7063220 | core_pubmed_pmc | Deciphering the Active Compounds and Mechanisms of Qixuehe Capsule on Qi Stagnation and Blood Stasis Syndrome: A Network Pharmacology Study | Deciphering the Active Compounds and Mechanisms of Qixuehe Capsule on Qi Stagnation and Blood Stasis Syndrome: A Network Pharmacology Study Abstract Background Qixuehe capsule (QXH), a Chinese patent medicine, has been demonstrated to be effective in the treatment of menstrual disorders. In traditional Chinese medicine... |
PMC7284436 | core_pubmed_pmc | Neuroprotective Effect of Ropinirole Lipid Nanoparticles Enriched Hydrogel for Parkinson’s Disease: In Vitro, Ex Vivo, Pharmacokinetic and Pharmacodynamic Evaluation | Neuroprotective Effect of Ropinirole Lipid Nanoparticles Enriched Hydrogel for Parkinson’s Disease: In Vitro, Ex Vivo, Pharmacokinetic and Pharmacodynamic Evaluation Abstract Abstract Parkinson’s disease (rp) is a progressive neurodegenerative disorder. Ropinirole (RP) is a newer generation dopamine agonist used for th... |
PMC7492550 | core_pubmed_pmc | Personalizing Treatment in IBD: Hype or Reality in 2020? Can We Predict Response to Anti-TNF? | Personalizing Treatment in IBD: Hype or Reality in 2020? Can We Predict Response to Anti-TNF? Abstract Abstract The advent of anti-TNF agents as the first approved targeted therapy in the treatment of inflammatory bowel disease (IBD) patients has made a major impact on our existing therapeutic algorithms. They have not... |
PMC9306593 | core_pubmed_pmc | Single‐Dose Pharmacokinetics and Safety of Ubrogepant in Adults With Hepatic Impairment: Results From an Open‐Label, Phase 1 Trial | Single‐Dose Pharmacokinetics and Safety of Ubrogepant in Adults With Hepatic Impairment: Results From an Open‐Label, Phase 1 Trial Abstract Abstract Ubrogepant is an oral calcitonin gene–related peptide receptor antagonist approved for the treatment of acute migraine headaches. Ubrogepant demonstrated efficacy and safe... |
PMC6479242 | core_pubmed_pmc | Pharmacokinetics of HLD200, a Delayed-Release and Extended-Release Methylphenidate: Evaluation of Dose Proportionality, Food Effect, Multiple-Dose Modeling, and Comparative Bioavailability with Immediate-Release Methylphenidate in Healthy Adults | Pharmacokinetics of HLD200, a Delayed-Release and Extended-Release Methylphenidate: Evaluation of Dose Proportionality, Food Effect, Multiple-Dose Modeling, and Comparative Bioavailability with Immediate-Release Methylphenidate in Healthy Adults Abstract Abstract Objectives: HLD200, an oral, once-daily, evening-dosed, ... |
PMC6853153 | core_pubmed_pmc | Pharmacokinetic and Pharmacodynamic Effects of Oral CXA ‐10, a Nitro Fatty Acid, After Single and Multiple Ascending Doses in Healthy and Obese Subjects | Pharmacokinetic and Pharmacodynamic Effects of Oral CXA ‐10, a Nitro Fatty Acid, After Single and Multiple Ascending Doses in Healthy and Obese Subjects Abstract 10‐nitro‐9(E)‐octadec‐9‐enoic acid (CXA‐10), a novel nitro fatty acid compound, demonstrates potential as a therapeutic agent in multiple disease indications ... |
PMC8722153 | core_pubmed_pmc | The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study | The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study Abstract Abstract Older age could be a risk factor for suboptimal CD4+ T-cell recovery in HIV-infected patients despite success... |
PMC11784244 | core_pubmed_pmc | Stage-specific pharmacodynamic chloroquine and pyronaridine action on artemisinin ring-stage resistant Kelch C580Y mutation Plasmodium falciparum correlates to hemozoin inhibition process | Stage-specific pharmacodynamic chloroquine and pyronaridine action on artemisinin ring-stage resistant Kelch C580Y mutation Plasmodium falciparum correlates to hemozoin inhibition process Abstract ABSTRACT The antimalarial quinolines pyronaridine and chloroquine both inhibit hemozoin crystallization, predominately prod... |
PMC6017025 | core_pubmed_pmc | Pharmacokinetics of Schizandrin and Its Pharmaceutical Products Assessed Using a Validated LC–MS/MS Method | Pharmacokinetics of Schizandrin and Its Pharmaceutical Products Assessed Using a Validated LC–MS/MS Method Abstract Schisandra chinensis has been used as an important component in various prescriptions in traditional Chinese medicine and, more recently, in Western-based medicine for its anti-hepatotoxic effect. The aim... |
PMC4404321 | core_pubmed_pmc | A Nonlinear Mixed Effects Approach for Modeling the Cell-To-Cell Variability of Mig1 Dynamics in Yeast | A Nonlinear Mixed Effects Approach for Modeling the Cell-To-Cell Variability of Mig1 Dynamics in Yeast Abstract The last decade has seen a rapid development of experimental techniques that allow data collection from individual cells. These techniques have enabled the discovery and characterization of variability within... |
PMC9122441 | core_pubmed_pmc | The disposition of trimethoprim and sulfadiazine in neonatal foals after intravenous administration | The disposition of trimethoprim and sulfadiazine in neonatal foals after intravenous administration Abstract Abstract Background Septicaemia in the neonatal foal is caused by both Gram positive and Gram negative bacteria. The life‐threatening nature of this condition requires treatment to be initiated with broad spectr... |
PMC7158076 | core_pubmed_pmc | An optimised dosing regimen versus a standard dosing regimen of vancomycin for the treatment of late onset sepsis due to Gram-positive microorganisms in neonates and infants aged less than 90 days (NeoVanc): study protocol for a randomised controlled trial | An optimised dosing regimen versus a standard dosing regimen of vancomycin for the treatment of late onset sepsis due to Gram-positive microorganisms in neonates and infants aged less than 90 days (NeoVanc): study protocol for a randomised controlled trial Abstract Abstract Background Vancomycin has been used in clinic... |
PMC12460201 | core_pubmed_pmc | Assessment of Pharmacokinetics and Safety with Bioequivalence of the Nitroglycerin Sublingual Tablets of Two Formulations in Chinese Healthy Subjects: A Bioequivalence Study | Assessment of Pharmacokinetics and Safety with Bioequivalence of the Nitroglycerin Sublingual Tablets of Two Formulations in Chinese Healthy Subjects: A Bioequivalence Study Abstract Abstract Background and Objective Nitroglycerin, a cornerstone therapy for acute angina pectoris, achieves rapid symptom relief through s... |
PMC12213970 | core_pubmed_pmc | Genetic variation of low-to-medium-affinity Fc-gamma receptors in Guillain-Barré syndrome | Genetic variation of low-to-medium-affinity Fc-gamma receptors in Guillain-Barré syndrome Abstract Abstract Introduction Fc-gamma receptors (FcγRs) are important for the effector functions of immunoglobulin G (IgG) and are therefore expected to play a role in the pathophysiology of Guillain-Barré syndrome (GBS). The FC... |
PMC11197031 | core_pubmed_pmc | Immune responsiveness in stable kidney transplantation patients: Complete inhibition of T‐cell proliferation but residual T‐cell activity during maintenance immunosuppressive treatment | Immune responsiveness in stable kidney transplantation patients: Complete inhibition of T‐cell proliferation but residual T‐cell activity during maintenance immunosuppressive treatment Abstract Abstract The recommended immunosuppressive treatment after kidney transplantation consists of tacrolimus, mycophenolate mofeti... |
PMC11249637 | core_pubmed_pmc | Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters | Interaction of the Atypical Tetracyclines Chelocardin and Amidochelocardin with Renal Drug Transporters Abstract Antimicrobial resistance is expected to increase mortality rates by up to several million deaths per year by 2050 without new treatment options at hand. Recently, we characterized the pharmacokinetic (PK) an... |
PMC10537057 | core_pubmed_pmc | Topical Sustained-Release Dexamethasone-Loaded Chitosan Nanoparticles: Assessment of Drug Delivery Efficiency in a Rabbit Model of Endotoxin-Induced Uveitis | Topical Sustained-Release Dexamethasone-Loaded Chitosan Nanoparticles: Assessment of Drug Delivery Efficiency in a Rabbit Model of Endotoxin-Induced Uveitis Abstract Abstract Uveitis is an ocular illness that if not treated properly can lead to a total loss of vision. In this study, we evaluated the utility of HA-coate... |
PMC11985606 | core_pubmed_pmc | Pharmacokinetics, metabolism, and excretion of [ 14 C]-valemetostat in healthy male participants, and in vitro plasma protein binding | Pharmacokinetics, metabolism, and excretion of [ 14 C]-valemetostat in healthy male participants, and in vitro plasma protein binding Abstract Abstract Introduction Valemetostat tosylate (valemetostat) is an oral, selective, dual inhibitor of enhancer of zeste homolog (EZH)2 and EZH1. This article reports findings on t... |
PMC3446644 | core_pubmed_pmc | Safety and Observations in a Pilot Study of Lenalidomide for Treatment in Autism | Safety and Observations in a Pilot Study of Lenalidomide for Treatment in Autism Abstract Autism affects 1 : 88 children in the United States. Familial history of autoimmune disease, autoantibodies in the serum of mothers when there is more than one autistic offspring, and neuroglial response in CSF and brain tissue in... |
PMC3378442 | core_pubmed_pmc | Effect of exenatide on the pharmacokinetics of a combination oral contraceptive in healthy women: an open-label, randomised, crossover trial | Effect of exenatide on the pharmacokinetics of a combination oral contraceptive in healthy women: an open-label, randomised, crossover trial Abstract Background Consistent with its effect on gastric emptying, exenatide, an injectable treatment for type 2 diabetes, may slow the absorption rate of concomitantly administe... |
PMC7303159 | core_pubmed_pmc | Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits | Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients—a genome-wide association study adjusting for smoking habits Abstract Clozapine (CLZ) is the superior antipsychotic drug for treatment of schizophrenia, but exhibits an extensive interpatient pharmacokinetic... |
PMC12818890 | core_pubmed_pmc | Evaluation of the Effect of Clobetasol Propionate on Circulating Cortisol and Growth Velocity in Children with Atopic Dermatitis: A Modelling and Simulation Study | Evaluation of the Effect of Clobetasol Propionate on Circulating Cortisol and Growth Velocity in Children with Atopic Dermatitis: A Modelling and Simulation Study Abstract Abstract Introduction Children with atopic dermatitis (AD) appear to have higher skin permeation, which may increase the risk of systemic adverse ev... |
PMC9025826 | core_pubmed_pmc | Linezolid Administration to Critically Ill Patients: Intermittent or Continuous Infusion? A Systematic Literature Search and Review | Linezolid Administration to Critically Ill Patients: Intermittent or Continuous Infusion? A Systematic Literature Search and Review Abstract Abstract A judicious antibiotic therapy is one of the challenges in the therapy of critically ill patients with sepsis and septic shock. The pathophysiological changes in these pa... |
PMC6138239 | core_pubmed_pmc | Pharmacokinetics of metformin in patients with chronic kidney disease stage 4 and metformin‐naïve type 2 diabetes | Pharmacokinetics of metformin in patients with chronic kidney disease stage 4 and metformin‐naïve type 2 diabetes Abstract Abstract The pharmacokinetics of metformin therapy in patients with chronic kidney disease stage 4 ( CKD ‐4) were studied using data from the largest Phase I consecutive cohort trial yet performed ... |
PMC9880359 | core_pubmed_pmc | Pharmacokinetic profile of acyclovir in a child receiving continuous kidney replacement therapy for acute liver failure | Pharmacokinetic profile of acyclovir in a child receiving continuous kidney replacement therapy for acute liver failure Abstract Background Continuous venovenous hemodiafiltration (CVVHDF) is one of the treatments of critically ill children presenting severe acute liver failure. This affliction might be induced by HSV ... |
PMC8016750 | core_pubmed_pmc | Population Pharmacokinetics of a Monthly Buprenorphine Depot Injection for the Treatment of Opioid Use Disorder: A Combined Analysis of Phase II and Phase III Trials | Population Pharmacokinetics of a Monthly Buprenorphine Depot Injection for the Treatment of Opioid Use Disorder: A Combined Analysis of Phase II and Phase III Trials Abstract Abstract Background BUP-XR (a.k.a. RBP-6000 or SUBLOCADE™) is an extended-release subcutaneous buprenorphine formulation for the treatment of opi... |
PMC4629093 | core_pubmed_pmc | Pharmacokinetics of levosulpiride after single and multiple intramuscular administrations in healthy Chinese volunteers | Pharmacokinetics of levosulpiride after single and multiple intramuscular administrations in healthy Chinese volunteers Abstract Abstract The main purpose of this study was to evaluate the pharmacokinetics of levosulpiride in humans after single and multiple intramuscular injections. Six males and six females received ... |
PMC3907819 | core_pubmed_pmc | Pharmacokinetic Comparison of Berberine in Rat Plasma after Oral Administration of Berberine Hydrochloride in Normal and Post Inflammation Irritable Bowel Syndrome Rats | Pharmacokinetic Comparison of Berberine in Rat Plasma after Oral Administration of Berberine Hydrochloride in Normal and Post Inflammation Irritable Bowel Syndrome Rats Abstract In the present study, post inflammation irritable bowel syndrome (PI-IBS) rats were firstly established by intracolonic instillation of acetic... |
PMC4729183 | core_pubmed_pmc | Simultaneous Determination and Pharmacokinetic Study of Losartan, Losartan Carboxylic Acid, Ramipril, Ramiprilat, and Hydrochlorothiazide in Rat Plasma by a Liquid Chromatography/Tandem Mass Spectrometry Method | Simultaneous Determination and Pharmacokinetic Study of Losartan, Losartan Carboxylic Acid, Ramipril, Ramiprilat, and Hydrochlorothiazide in Rat Plasma by a Liquid Chromatography/Tandem Mass Spectrometry Method Abstract The monitoring of the plasmatic concentrations of cardiovascular drugs is crucial for understanding ... |
PMC12329059 | core_pubmed_pmc | Comparison of pharmacokinetic and pharmacodynamic properties of allopurinol and benzbromarone in a quail model of hyperuricemia | Comparison of pharmacokinetic and pharmacodynamic properties of allopurinol and benzbromarone in a quail model of hyperuricemia Abstract Importance Hyperuricemia (HUA) is a major metabolic disorder in poultry, leading to gout and kidney damage, which affects farm productivity. Accordingly, understanding the pharmacodyn... |
PMC7280149 | core_pubmed_pmc | Mechanistic insights of the controlled release capacity of polar functional group in transdermal drug delivery system: the relationship of hydrogen bonding strength and controlled release capacity | Mechanistic insights of the controlled release capacity of polar functional group in transdermal drug delivery system: the relationship of hydrogen bonding strength and controlled release capacity Abstract Abstract Background Hydrogen bonding interaction was considered to play a critical role in controlling drug releas... |
PMC6153812 | core_pubmed_pmc | Population Pharmacokinetics of Artemether, Dihydroartemisinin, and Lumefantrine in Rwandese Pregnant Women Treated for Uncomplicated Plasmodium falciparum Malaria | Population Pharmacokinetics of Artemether, Dihydroartemisinin, and Lumefantrine in Rwandese Pregnant Women Treated for Uncomplicated Plasmodium falciparum Malaria Abstract The artemisinin-based combination therapy artemether-lumefantrine is commonly used in pregnant malaria patients. However, the effect of pregnancy-re... |
PMC8877570 | core_pubmed_pmc | Population Pharmacokinetics of Hydroxychloroquine and 3 Metabolites in COVID-19 Patients and Pharmacokinetic/Pharmacodynamic Application | Population Pharmacokinetics of Hydroxychloroquine and 3 Metabolites in COVID-19 Patients and Pharmacokinetic/Pharmacodynamic Application Abstract We develop a population pharmacokinetic model for hydroxychloroquine (HCQ) and three of its metabolites (desethylhydroxychloroquine, Des HCQ; desethylchloroquine, DesCQ; and ... |
PMC7582776 | core_pubmed_pmc | In Vitro Interaction of AB-FUBINACA with Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes and Drug Transporters | In Vitro Interaction of AB-FUBINACA with Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes and Drug Transporters Abstract AB-FUBINACA, a synthetic indazole carboxamide cannabinoid, has been used worldwide as a new psychoactive substance. Because drug abusers take various drugs concomitantly, it is necessary to... |
PMC12736365 | core_pubmed_pmc | Towards Personalized Lymphodepletion: A Population Pharmacokinetic Fludarabine Model in Patients Receiving CAR T-Cell Therapy | Towards Personalized Lymphodepletion: A Population Pharmacokinetic Fludarabine Model in Patients Receiving CAR T-Cell Therapy Abstract Background/Objectives: Optimal fludarabine dosing in the conditioning regimen based on population pharmacokinetic analysis (popPK) can predict outcomes in patients receiving hematopoiet... |
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