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PMC6616248 | core_pubmed_pmc | Dosage Related Efficacy and Tolerability of Cannabidiol in Children With Treatment-Resistant Epileptic Encephalopathy: Preliminary Results of the CARE-E Study | Dosage Related Efficacy and Tolerability of Cannabidiol in Children With Treatment-Resistant Epileptic Encephalopathy: Preliminary Results of the CARE-E Study Abstract Purpose: There is uncertainty regarding the appropriate dose of Cannabidiol (CBD) for childhood epilepsy. We present the preliminary data of seven parti... |
PMC6349757 | core_pubmed_pmc | Exposure of Infants to Isoniazid via Breast Milk After Maternal Drug Intake of Recommended Doses Is Clinically Insignificant Irrespective of Metaboliser Status. A Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach to Estimate Drug Exposure of Infants via Breast-Feeding | Exposure of Infants to Isoniazid via Breast Milk After Maternal Drug Intake of Recommended Doses Is Clinically Insignificant Irrespective of Metaboliser Status. A Physiologically-Based Pharmacokinetic (PBPK) Modelling Approach to Estimate Drug Exposure of Infants via Breast-Feeding Abstract Abstract Isoniazid is a firs... |
PMC6509210 | core_pubmed_pmc | ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma | ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma Abstract Diffuse intrinsic pontine glioma (DIPG) is a lethal childhood brainstem tumour, with a quarter of patients harbouring somatic mutations in ACVR1 , encoding the serine/threonine kinase ALK2. Despite... |
PMC10455840 | core_pubmed_pmc | A Critical Review on the Dosing and Safety of Antifungals Used in Exotic Avian and Reptile Species | A Critical Review on the Dosing and Safety of Antifungals Used in Exotic Avian and Reptile Species Abstract Abstract Antifungals are used in exotic avian and reptile species for the treatment of fungal diseases. Dose extrapolations across species are common due to lack of species-specific pharmacological data. This may... |
PMC10777433 | core_pubmed_pmc | No drug–drug interactions between selective prolyl‐tRNA synthetase inhibitor, bersiporocin, and pirfenidone or nintedanib in healthy participants | No drug–drug interactions between selective prolyl‐tRNA synthetase inhibitor, bersiporocin, and pirfenidone or nintedanib in healthy participants Abstract Abstract Bersiporocin, a potent and selective prolyl‐tRNA synthetase inhibitor, is expected to show a synergistic effect with pirfenidone or nintedanib in patients w... |
PMC7785128 | core_pubmed_pmc | Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance: narrative review | Tigecycline antibacterial activity, clinical effectiveness, and mechanisms and epidemiology of resistance: narrative review Abstract Tigecycline is unique glycylcycline class of semisynthetic antimicrobial agents developed for the treatment of polymicrobial infections caused by multidrug-resistant Gram-positive and Gra... |
PMC7696167 | core_pubmed_pmc | Non-Linear Pharmacokinetics of Oral Roscovitine (Seliciclib) in Cystic Fibrosis Patients Chronically Infected with Pseudomonas aeruginosa : A Study on Population Pharmacokinetics with Monte Carlo Simulations | Non-Linear Pharmacokinetics of Oral Roscovitine (Seliciclib) in Cystic Fibrosis Patients Chronically Infected with Pseudomonas aeruginosa : A Study on Population Pharmacokinetics with Monte Carlo Simulations Abstract Roscovitine (Seliciclib), a new protein kinase inhibitor, was administered orally to adult patients wit... |
PMC10948865 | core_pubmed_pmc | Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats: sex matters | Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats: sex matters Abstract Abstract Though vaping likely represents a safer alternative to smoking, it is not without risks, many of which are not well understood, especially for vulnerable popula... |
PMC6001839 | core_pubmed_pmc | Pharmacokinetics and pharmacodynamics of linezolid in plasma/cerebrospinal fluid in patients with cerebral hemorrhage after lateral ventricular drainage by Monte Carlo simulation | Pharmacokinetics and pharmacodynamics of linezolid in plasma/cerebrospinal fluid in patients with cerebral hemorrhage after lateral ventricular drainage by Monte Carlo simulation Abstract Objective We investigated the pharmacokinetic (PK) and pharmacodynamic (PD) parameters of linezolid in patients who had suffered cer... |
PMC8063233 | core_pubmed_pmc | Dapagliflozin Added to Verinurad Plus Febuxostat Further Reduces Serum Uric Acid in Hyperuricemia: The QUARTZ Study | Dapagliflozin Added to Verinurad Plus Febuxostat Further Reduces Serum Uric Acid in Hyperuricemia: The QUARTZ Study Abstract Abstract Context Combining a sodium-glucose cotransporter 2 inhibitor with a xanthine oxidase inhibitor (XOI) and a urate transporter 1 (URAT1) inhibitor may enhance serum uric acid (sUA) lowerin... |
PMC7116968 | core_pubmed_pmc | Panax ginseng and Panax quinquefolius : From pharmacology to toxicology | Panax ginseng and Panax quinquefolius : From pharmacology to toxicology Abstract The use of Panax ginseng and Panax quinquefolius in traditional Chinese medicine dates back to about 5000 years ago thanks to its several beneficial and healing properties. Over the past few years, extensive preclinical and clinical eviden... |
PMC4816246 | core_pubmed_pmc | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Rising TAK-438 (Vonoprazan) Doses in Healthy Male Japanese/non-Japanese Subjects | Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Rising TAK-438 (Vonoprazan) Doses in Healthy Male Japanese/non-Japanese Subjects Abstract OBJECTIVES: To evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of TAK-438 (vonoprazan, a potassium-competitive acid blocker) in healthy m... |
PMC8539938 | core_pubmed_pmc | Development of Lactoferrin-Loaded Liposomes for the Management of Dry Eye Disease and Ocular Inflammation | Development of Lactoferrin-Loaded Liposomes for the Management of Dry Eye Disease and Ocular Inflammation Abstract Abstract Dry eye disease (DED) is a high prevalent multifactorial disease characterized by a lack of homeostasis of the tear film which causes ocular surface inflammation, soreness, and visual disturbance.... |
PMC7877829 | core_pubmed_pmc | Risk Assessment of Drug‐Induced Long QT Syndrome for Some COVID‐19 Repurposed Drugs | Risk Assessment of Drug‐Induced Long QT Syndrome for Some COVID‐19 Repurposed Drugs Abstract Abstract The risk‐benefit ratio associated with the use of repurposed drugs to treat severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2)‐related infectious coronavirus disease 2019 (COVID‐19) is complicated because ben... |
PMC12968790 | core_pubmed_pmc | Targeting mitochondrial quality control in osteoarthritis with GrpE-like 1-loaded synovial mesenchymal stromal/stem cell small extracellular vesicles | Targeting mitochondrial quality control in osteoarthritis with GrpE-like 1-loaded synovial mesenchymal stromal/stem cell small extracellular vesicles Abstract Recent studies have demonstrated that synovial mesenchymal stem cell-derived small extracellular vesicles (EVs) engineered to deliver GrpE-like 1 activated PTEN-... |
PMC12239925 | core_pubmed_pmc | Materials, Syntheses and Biomedical Applications of Nano-Quercetin Formulations: A Comprehensive Literature Review | Materials, Syntheses and Biomedical Applications of Nano-Quercetin Formulations: A Comprehensive Literature Review Abstract Abstract Quercetin (Qu), a naturally occurring flavonoid with potent antioxidant, anti-inflammatory, and anticancer properties, faces clinical limitations due to poor solubility, low stability, an... |
PMC10370898 | core_pubmed_pmc | SuperNatural inhibitors to reverse multidrug resistance emerged by ABCB1 transporter: Database mining, lipid-mediated molecular dynamics, and pharmacokinetics study | SuperNatural inhibitors to reverse multidrug resistance emerged by ABCB1 transporter: Database mining, lipid-mediated molecular dynamics, and pharmacokinetics study Abstract An effective approach to reverse multidrug resistance (MDR) is P-glycoprotein (P-gp, ABCB1) transport inhibition. To identify such molecular regul... |
PMC5783144 | core_pubmed_pmc | A review of the pharmacology and clinical efficacy of brivaracetam | A review of the pharmacology and clinical efficacy of brivaracetam Abstract Brivaracetam (BRV; Briviact) is a new antiepileptic drug (AED) approved for adjunctive treatment of focal (partial-onset) seizures in adults. BRV is a selective, high-affinity ligand for synaptic vesicle 2A (SV2A) with 15- to 30-fold higher aff... |
PMC6567057 | core_pubmed_pmc | Pharmacokinetic, metabolic stability, plasma protein binding and CYP450s inhibition/induction assessment studies of N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide as potential type 5 phosphodiesterase inhibitors | Pharmacokinetic, metabolic stability, plasma protein binding and CYP450s inhibition/induction assessment studies of N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide as potential type 5 phosphodiesterase inhibitors Abstract ABSTRACT N-(2-pyridylmethyl)-2-hyd... |
PMC12579685 | core_pubmed_pmc | Switching Patients with Schizophrenia from Intramuscular Paliperidone Palmitate Once Monthly to TV-46000, a Long-Acting Subcutaneous Antipsychotic: Population Pharmacokinetic–Based Strategies | Switching Patients with Schizophrenia from Intramuscular Paliperidone Palmitate Once Monthly to TV-46000, a Long-Acting Subcutaneous Antipsychotic: Population Pharmacokinetic–Based Strategies Abstract Introduction Pharmacokinetic differences between long-acting injectable antipsychotic (LAI) formulations, combined with... |
PMC3309646 | core_pubmed_pmc | Preparation of Evodiamine Solid Dispersions and Its Pharmacokinetics | Preparation of Evodiamine Solid Dispersions and Its Pharmacokinetics Abstract In order to increase the dissolution rate and bioavailability, solid dispersions of evodiamine in PVP K 30 with different enriched samples of evodiamine to PVP K 30 ratios were prepared by solvent method. Our studies showed that the dissoluti... |
PMC5845165 | core_pubmed_pmc | Pharmacokinetic Study of 7 Compounds Following Oral Administration of Fructus Aurantii to Depressive Rats | Pharmacokinetic Study of 7 Compounds Following Oral Administration of Fructus Aurantii to Depressive Rats Abstract Abstract In the present study, the pharmacokinetics of multi-components (naringenin, nobiletin, meranzin hydrate, narirutin, naringin, hesperidin, and neohesperidin) were investigated in acute depressive r... |
PMC4546378 | core_pubmed_pmc | Single Doses up to 800 mg of E-52862 Do Not Prolong the QTc Interval – A Retrospective Validation by Pharmacokinetic-Pharmacodynamic Modelling of Electrocardiography Data Utilising the Effects of a Meal on QTc to Demonstrate ECG Assay Sensitivity | Single Doses up to 800 mg of E-52862 Do Not Prolong the QTc Interval – A Retrospective Validation by Pharmacokinetic-Pharmacodynamic Modelling of Electrocardiography Data Utilising the Effects of a Meal on QTc to Demonstrate ECG Assay Sensitivity Abstract Background E-52862 is a Sigma-1 receptor antagonist (S1RA) curre... |
PMC11963541 | core_pubmed_pmc | Within-host modeling of primaquine-induced hemolysis in hemizygote glucose-6-phosphate dehydrogenase deficient healthy volunteers | Within-host modeling of primaquine-induced hemolysis in hemizygote glucose-6-phosphate dehydrogenase deficient healthy volunteers Abstract ABSTRACT Primaquine is the only widely available drug to prevent relapses of Plasmodium vivax malaria. Primaquine is underused because of concerns over oxidant hemolysis in glucose-... |
PMC7796052 | core_pubmed_pmc | Discovery of a Bradykinin B2 Partial Agonist Profile of Raloxifene in a Drug Repurposing Campaign | Discovery of a Bradykinin B2 Partial Agonist Profile of Raloxifene in a Drug Repurposing Campaign Abstract Abstract Covid-19 urges a deeper understanding of the underlying molecular mechanisms involved in illness progression to provide a prompt therapeutical response with an adequate use of available drugs, including d... |
PMC8212765 | core_pubmed_pmc | Probability of pharmacological target attainment with flucloxacillin in Staphylococcus aureus bloodstream infection: a prospective cohort study of unbound plasma and individual MICs | Probability of pharmacological target attainment with flucloxacillin in Staphylococcus aureus bloodstream infection: a prospective cohort study of unbound plasma and individual MICs Abstract Abstract Objectives MSSA bloodstream infections (BSIs) are associated with considerable mortality. Data regarding therapeutic dru... |
PMC11887333 | core_pubmed_pmc | Antimicrobial peptide biological activity, delivery systems and clinical translation status and challenges | Antimicrobial peptide biological activity, delivery systems and clinical translation status and challenges Abstract Antibiotic resistance is currently one of the most significant threats to global public health and safety. And studies have found that over the next 25 years, 39 million people will die directly and 169 m... |
PMC12836115 | core_pubmed_pmc | Muscle mass correlates with rocuronium distribution volume and guides dose optimization in obese colorectal cancer patients | Muscle mass correlates with rocuronium distribution volume and guides dose optimization in obese colorectal cancer patients Abstract Abstract BACKGROUND Perioperative anesthesia management of obese patients presents significant challenges as traditional total body weight-based dosing fails to achieve optimal anesthetic... |
PMC10535589 | core_pubmed_pmc | Therapeutic Drug Monitoring (TDM) Implementation in Public Hospitals in Greece in 2003 and 2021: A Comparative Analysis of TDM Evolution over the Years | Therapeutic Drug Monitoring (TDM) Implementation in Public Hospitals in Greece in 2003 and 2021: A Comparative Analysis of TDM Evolution over the Years Abstract Therapeutic drug monitoring (TDM) is the clinical practice of measuring drug concentrations. TDM can be used to determine treatment efficacy and to prevent the... |
PMC10358706 | core_pubmed_pmc | Prevalence of polypharmacy and risk of potential drug-drug interactions among hospitalized patients with emphasis on the pharmacokinetics | Prevalence of polypharmacy and risk of potential drug-drug interactions among hospitalized patients with emphasis on the pharmacokinetics Abstract Abstract Background: Both polypharmacy and potential drug-drug interactions (pDDIs), especially those at the pharmacokinetic level, are common in hospitalized patients and a... |
PMC12895386 | core_pubmed_pmc | Anesthesia Practices for Preterm Infants: A Survey in the Nordic Countries and Review of the Literature | Anesthesia Practices for Preterm Infants: A Survey in the Nordic Countries and Review of the Literature Abstract ABSTRACT Background Preterm infants are at increased risk of perioperative mortality and are among the most vulnerable patients anesthesiologists can encounter. The literature on anesthesia practice in prete... |
PMC10649763 | core_pubmed_pmc | Hepatic Impairment as a Risk Factor for Drug Safety: Suitability and Comparison of Four Liver Scores as Screening Tools | Hepatic Impairment as a Risk Factor for Drug Safety: Suitability and Comparison of Four Liver Scores as Screening Tools Abstract Hepatic impairment (HI) influences the pharmacokinetics and pharmacodynamics of drugs and represents an important risk factor for drug safety. A reliable screening tool for HI identification ... |
PMC11535297 | core_pubmed_pmc | Mechanism of Action and Pharmacokinetics of Approved Bispecific Antibodies | Mechanism of Action and Pharmacokinetics of Approved Bispecific Antibodies Abstract Abstract Bispecific antibodies represent a significant advancement in therapeutic antibody engineering, offering the ability to simultaneously target two distinct antigens. This dual-targeting capability enhances therapeutic efficacy, e... |
PMC10509375 | core_pubmed_pmc | Green synthesis of Piper nigrum copper-based nanoparticles: in silico study and ADMET analysis to assess their antioxidant, antibacterial, and cytotoxic effects | Green synthesis of Piper nigrum copper-based nanoparticles: in silico study and ADMET analysis to assess their antioxidant, antibacterial, and cytotoxic effects Abstract Abstract Nanobiotechnology is a popular branch of science that is gaining interest among scientists and researchers as it allows for the green manufac... |
PMC6057540 | core_pubmed_pmc | Safety, tolerability and pharmacokinetics of shorter duration of infusion of obinutuzumab in Japanese patients with B-cell non-Hodgkin lymphoma: final results of the phase II GATS study | Safety, tolerability and pharmacokinetics of shorter duration of infusion of obinutuzumab in Japanese patients with B-cell non-Hodgkin lymphoma: final results of the phase II GATS study Abstract Abstract Background Shorter duration of infusion of monoclonal antibody treatments may reduce treatment burden and improve he... |
PMC12030455 | core_pubmed_pmc | The Emergence of Psilocybin in Psychiatry and Neuroscience | The Emergence of Psilocybin in Psychiatry and Neuroscience Abstract Abstract Psilocybin, a naturally occurring psychedelic compound, has garnered renewed scientific interest for its potential in treating psychiatric and neurological disorders. This review systematically examines the latest research on psilocybin’s phar... |
PMC10499420 | core_pubmed_pmc | Anti‐inflammatory effects of dexamethasone in COVID ‐19 patients: Translational population PK / PD modeling and simulation | Anti‐inflammatory effects of dexamethasone in COVID ‐19 patients: Translational population PK / PD modeling and simulation Abstract Abstract Dexamethasone (DEX) given at a dose of 6 mg once‐daily for 10 days is a recommended dosing regimen in patients with coronavirus disease 2019 (COVID‐19) requiring oxygen therapy. W... |
PMC11442000 | core_pubmed_pmc | Pharmacokinetic/pharmacodynamic model-based optimization of temocillin dosing strategies for the treatment of systemic infections | Pharmacokinetic/pharmacodynamic model-based optimization of temocillin dosing strategies for the treatment of systemic infections Abstract Abstract Background Temocillin is increasingly considered as an alternative to carbapenems. However, there is no consensus on optimal dosing strategies and limited data on temocilli... |
PMC6754125 | core_pubmed_pmc | Safety and pharmacokinetics of dolutegravir in pregnant mothers with HIV infection and their neonates: A randomised trial (DolPHIN-1 study) | Safety and pharmacokinetics of dolutegravir in pregnant mothers with HIV infection and their neonates: A randomised trial (DolPHIN-1 study) Abstract Abstract Background The global transition to use of dolutegravir (DTG) in WHO-preferred regimens for HIV treatment is limited by lack of knowledge on use in pregnancy. Her... |
PMC5890854 | core_pubmed_pmc | Safety, tolerability and pharmacokinetics of subcutaneous and intravenous anifrolumab in healthy volunteers | Safety, tolerability and pharmacokinetics of subcutaneous and intravenous anifrolumab in healthy volunteers Abstract Objectives To compare the pharmacokinetics (PK), safety and tolerability of subcutaneous (SC) and intravenous anifrolumab, an anti–type I interferon receptor monoclonal antibody in development for SLE, i... |
PMC12916759 | core_pubmed_pmc | Pharmacokinetics, pathology and efficacy of SARS-CoV-2 main protease inhibitor VPC285785 in a murine model of coronavirus infection | Pharmacokinetics, pathology and efficacy of SARS-CoV-2 main protease inhibitor VPC285785 in a murine model of coronavirus infection Abstract Abstract Herein we report the development of novel covalent inhibitors of the SARS-CoV-2 main protease (Mpro). The developed compounds VPC285785 and VPC285786 demonstrated moderat... |
PMC9778400 | core_pubmed_pmc | Construction of an MLR-QSAR Model Based on Dietary Flavonoids and Screening of Natural α-Glucosidase Inhibitors | Construction of an MLR-QSAR Model Based on Dietary Flavonoids and Screening of Natural α-Glucosidase Inhibitors Abstract Abstract Postprandial hyperglycemia can be reduced by inhibiting α-glucosidase activity. Common α-glucosidase inhibitors such as acarbose may have various side effects. Therefore, it is important to ... |
PMC7568551 | core_pubmed_pmc | A novel assay to measure calcification propensity: from laboratory to humans | A novel assay to measure calcification propensity: from laboratory to humans Abstract Abstract Cardiovascular calcification (CVC) contributes to morbidity and mortality in patients undergoing dialysis. We examined the pharmacodynamic effects of SNF472, a calcification inhibitor, on plasma calcium phosphate crystallizat... |
PMC6825008 | core_pubmed_pmc | Individual optimal dose of amrubicin to prevent severe neutropenia in Japanese patients with lung cancer | Individual optimal dose of amrubicin to prevent severe neutropenia in Japanese patients with lung cancer Abstract Abstract This study determined individual optimal amrubicin doses for Japanese patients with lung cancer after platinum‐based treatment. We carried out population pharmacokinetic and pharmacodynamic modelin... |
PMC8528265 | core_pubmed_pmc | Results of a phase I trial to assess the safety of macitentan in combination with temozolomide for the treatment of recurrent glioblastoma | Results of a phase I trial to assess the safety of macitentan in combination with temozolomide for the treatment of recurrent glioblastoma Abstract Abstract Background There is an urgent need for additional therapies to treat recurrent glioblastoma (GBM). Preclinical studies suggest that high dose macitentan, an oral d... |
PMC11079524 | core_pubmed_pmc | The baicalein amorphous solid dispersion to enhance the dissolution and bioavailability and effects on growth performance, meat quality, antioxidant capacity and intestinal flora in Taihang chickens | The baicalein amorphous solid dispersion to enhance the dissolution and bioavailability and effects on growth performance, meat quality, antioxidant capacity and intestinal flora in Taihang chickens Abstract Baicalein ( BAI ) is a natural flavonoid with antioxidant, antitumor and antibacterial properties. However, the ... |
PMC11683673 | core_pubmed_pmc | Phase I Trial of Upamostat Combined With Gemcitabine in Locally Unresectable or Metastatic Pancreatic Cancer: Safety and Preliminary Efficacy Assessment | Phase I Trial of Upamostat Combined With Gemcitabine in Locally Unresectable or Metastatic Pancreatic Cancer: Safety and Preliminary Efficacy Assessment Abstract ABSTRACT Aim This study aimed to determine the maximum tolerated dose (MTD) of the urokinase plasminogen activator (uPA) inhibitor upamostat (LH011) in combin... |
PMC12641067 | core_pubmed_pmc | Population Pharmacokinetic Modeling of Glycochenodeoxycholic Acid 3‐O‐Sulfate ( GCDCA ‐S) as Endogenous Biomarker of OATP1B3 and OAT3 Transporters | Population Pharmacokinetic Modeling of Glycochenodeoxycholic Acid 3‐O‐Sulfate ( GCDCA ‐S) as Endogenous Biomarker of OATP1B3 and OAT3 Transporters Abstract Endogenous biomarkers for drug transporters are an emerging tool for the assessment of transporter‐mediated drug–drug interactions (DDI). Glycochenodeoxycholic acid... |
PMC6676270 | core_pubmed_pmc | Sustained safe and effective anticoagulation using Edoxaban via percutaneous endoscopic gastrostomy | Sustained safe and effective anticoagulation using Edoxaban via percutaneous endoscopic gastrostomy Abstract Abstract Extensive data support the safety of direct oral anticoagulants compared with vitamin K antagonists in patients with non‐valvular atrial fibrillation, leading to a significantly increase in the use of t... |
PMC10787778 | core_pubmed_pmc | First-in-human phase I dose escalation trial of the first-in-class tumor microenvironment modulator VT1021 in advanced solid tumors | First-in-human phase I dose escalation trial of the first-in-class tumor microenvironment modulator VT1021 in advanced solid tumors Abstract Abstract Background VT1021 is a cyclic peptide that induces the expression of thrombospondin-1 (TSP-1) in myeloid-derived suppressor cells (MDSCs) recruited to the tumor microenvi... |
PMC6009891 | core_pubmed_pmc | Novel series of 1,2,4-trioxane derivatives as antimalarial agents | Novel series of 1,2,4-trioxane derivatives as antimalarial agents Abstract Abstract Among three series of 1,2,4-trioxane derivatives, five compounds showed good in vitro antimalarial activity, three compounds of which exhibited better activity against P. falciparum resistant (RKL9) strain than the sensitive (3D7) one. ... |
PMC5105357 | core_pubmed_pmc | Pharmacokinetic Studies of Sustained-Release Depot of Dexamethasone in Beagle Dogs | Pharmacokinetic Studies of Sustained-Release Depot of Dexamethasone in Beagle Dogs Abstract Abstract Purpose: To examine the pharmacokinetic characteristics of sustained-release dexamethasone depots in two separate canine studies. Methods: Dexamethasone depots loaded with a clinically representative (0.4 mg) dose (DEXT... |
PMC7608064 | core_pubmed_pmc | Absence of gender influence on the pharmacokinetics of chloroquine combined with primaquine in malaria vivax patients | Absence of gender influence on the pharmacokinetics of chloroquine combined with primaquine in malaria vivax patients Abstract ABSTRACT Chloroquine is the first-line therapy against the asexual stages of Plasmodium vivax . There is a high variation of chloroquine plasma levels after therapeutic doses, which can lead to... |
PMC10453147 | core_pubmed_pmc | Sex Differences in Therapies against Myocardial Ischemia-Reperfusion Injury: From Basic Science to Clinical Perspectives | Sex Differences in Therapies against Myocardial Ischemia-Reperfusion Injury: From Basic Science to Clinical Perspectives Abstract Abstract Mortality from myocardial infarction (MI) has declined over recent decades, which could be attributed in large part to improved treatment methods. Early reperfusion is the cornersto... |
PMC11267486 | core_pubmed_pmc | Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects | Insights into the stereoisomerism of dihydroquercetin: analytical and pharmacological aspects Abstract Abstract Dihydroquercetin (DHQ) is a representative of flavonoids that is available on the market as a food supplement and registered as an active pharmaceutical ingredient. The structure of this compound is character... |
PMC9582183 | core_pubmed_pmc | Maximum Entropy Technique and Regularization Functional for Determining the Pharmacokinetic Parameters in DCE-MRI | Maximum Entropy Technique and Regularization Functional for Determining the Pharmacokinetic Parameters in DCE-MRI Abstract Abstract This paper aims to solve the arterial input function (AIF) determination in dynamic contrast-enhanced MRI (DCE-MRI), an important linear ill-posed inverse problem, using the maximum entrop... |
PMC6920897 | core_pubmed_pmc | Interactions of 7,8-Dihydroxyflavone with Serum Albumin as well as with CYP2C9, CYP2C19, CYP3A4, and Xanthine Oxidase Biotransformation Enzymes | Interactions of 7,8-Dihydroxyflavone with Serum Albumin as well as with CYP2C9, CYP2C19, CYP3A4, and Xanthine Oxidase Biotransformation Enzymes Abstract 7,8-dihydroxyflavone (DHF) is a flavone aglycone which has beneficial effects in several central nervous system diseases. Most of the pharmacokinetic properties of DHF... |
PMC8182214 | core_pubmed_pmc | Dual drug-induced aseptic meningoencephalitis: More than a suggestion | Dual drug-induced aseptic meningoencephalitis: More than a suggestion Abstract We present the case of a patient with a first single episode of a dual drug-induced aseptic mening (DIAM) due to amoxicillin and ibuprofen and a short review of updated literature. A 76-year-old man was admitted to our hospital with slowness... |
PMC12123189 | core_pubmed_pmc | Population Pharmacokinetic Analysis and Pharmacodynamic Evaluation of Sulbactam in Pediatric Patients: Dosing Suggestions for Acinetobacter baumannii Infections | Population Pharmacokinetic Analysis and Pharmacodynamic Evaluation of Sulbactam in Pediatric Patients: Dosing Suggestions for Acinetobacter baumannii Infections Abstract Abstract Background This study aims to develop a population pharmacokinetic (PK) model of sulbactam in pediatric patients using pooled data analysis, ... |
PMC11247666 | core_pubmed_pmc | A small‐molecule microtubule‐stabilizing agent safely reduces Aβ plaque and tau pathology in transgenic mouse models of Alzheimer's disease | A small‐molecule microtubule‐stabilizing agent safely reduces Aβ plaque and tau pathology in transgenic mouse models of Alzheimer's disease Abstract Abstract INTRODUCTION Intraneuronal inclusions composed of tau protein are found in Alzheimer's disease (AD) and other tauopathies. Tau normally binds microtubules (MTs), ... |
PMC8145202 | core_pubmed_pmc | Polymerized Albumin Receptor of Hepatitis B Virus for Evading the Reticuloendothelial System | Polymerized Albumin Receptor of Hepatitis B Virus for Evading the Reticuloendothelial System Abstract Various strategies, such as optimization of surface chemistry, size, shape, and charge, have been undertaken to develop nanoparticles (NPs) as DDS (drug delivery system) nanocarriers for evading the reticuloendothelial... |
PMC10978739 | core_pubmed_pmc | Nano-radiopharmaceuticals as therapeutic agents | Nano-radiopharmaceuticals as therapeutic agents Abstract Abstract In recent years, there has been an increased interest in exploring the potential synergy between nanotechnology and nuclear medicine. The application of radioactive isotopes, commonly referred to as radiopharmaceuticals, is recognized in nuclear medicine... |
PMC12965103 | core_pubmed_pmc | Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Intravenous Vancomycin in Intracranial Hemorrhage Patients with External Ventricular Drains: Implications for Dosing and Therapeutic Drug Monitoring | Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Intravenous Vancomycin in Intracranial Hemorrhage Patients with External Ventricular Drains: Implications for Dosing and Therapeutic Drug Monitoring Abstract Purpose Vancomycin is frequently used to treat central nervous system (CNS) infections, yet its... |
PMC10640690 | core_pubmed_pmc | Pharmacokinetic Data of Dolutegravir in Second-line Treatment of Children With Human Immunodeficiency Virus: Results From the CHAPAS4 Trial | Pharmacokinetic Data of Dolutegravir in Second-line Treatment of Children With Human Immunodeficiency Virus: Results From the CHAPAS4 Trial Abstract Abstract Background Dolutegravir (DTG), combined with a backbone of 2 nucleoside reverse transcriptase inhibitors, is currently the preferred first-line treatment for huma... |
PMC5786750 | core_pubmed_pmc | Pharmacokinetics and Safety of Omadacycline in Subjects with Impaired Renal Function | Pharmacokinetics and Safety of Omadacycline in Subjects with Impaired Renal Function Abstract ABSTRACT Many antibiotics require dose adjustments in patients with renal impairment and/or in those undergoing hemodialysis. Omadacycline, the first aminomethylcycline antibiotic in late-stage clinical development, displays a... |
PMC5836847 | core_pubmed_pmc | Evaluation of Pharmacokinetic and Pharmacodynamic Drug–Drug Interaction of Sacubitril/Valsartan (LCZ696) and Sildenafil in Patients With Mild‐to‐Moderate Hypertension | Evaluation of Pharmacokinetic and Pharmacodynamic Drug–Drug Interaction of Sacubitril/Valsartan (LCZ696) and Sildenafil in Patients With Mild‐to‐Moderate Hypertension Abstract Sacubitril/valsartan (LCZ696) is indicated for the treatment of patients with heart failure and reduced ejection fraction (HFrEF). Since patient... |
PMC4448465 | core_pubmed_pmc | Pharmacokinetic profile of paclitaxel in the plasma, lung, and diaphragm following intravenous or intrapleural administration in rats | Pharmacokinetic profile of paclitaxel in the plasma, lung, and diaphragm following intravenous or intrapleural administration in rats Abstract Abstract Background The optimal chemotherapy route for non-small cell lung cancers involving the phrenic nerve and diaphragm is unclear. The pharmacokinetic properties of paclit... |
PMC9345591 | core_pubmed_pmc | Vancomycin area under the curve-guided monitoring in pediatric patients | Vancomycin area under the curve-guided monitoring in pediatric patients Abstract Abstract Objective: To assess the percentage of vancomycin area under the curve/minimum inhibitory concentration target attainment in pediatric patients after the empirical dose regimen and to demonstrate the applicability of this method f... |
PMC5405979 | core_pubmed_pmc | Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats | Pharmacokinetic and pharmacodynamic modelling after subcutaneous, intravenous and buccal administration of a high-concentration formulation of buprenorphine in conscious cats Abstract Abstract Background The aim of this study was to describe the joint pharmacokinetic-pharmacodynamic model and evaluate thermal antinocic... |
PMC8718548 | core_pubmed_pmc | Sedation, Analgesia, and Muscle Relaxation During VV-ECMO Therapy in Patients With Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2): A Single-Center, Retrospective, Observational Study | Sedation, Analgesia, and Muscle Relaxation During VV-ECMO Therapy in Patients With Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2): A Single-Center, Retrospective, Observational Study Abstract Abstract Objective: The pharmacokinetics and pharmacodynamics of ECMO-supported sedative, analgesic, and musc... |
PMC9344054 | core_pubmed_pmc | Studies on Chemical Characterization of Ginkgo Amillaria Oral Solution and Its Drug–Drug Interaction With Piceatannol 3′- O - β -D-Glucopyranoside for Injection | Studies on Chemical Characterization of Ginkgo Amillaria Oral Solution and Its Drug–Drug Interaction With Piceatannol 3′- O - β -D-Glucopyranoside for Injection Abstract Abstract Ginkgo Amillaria oral solution (GAO) is commonly used for the treatment of cardiovascular and cerebrovascular diseases in China. Piceatannol-... |
PMC11832584 | core_pubmed_pmc | The population-specific Thr44Met OCT3 coding variant affects metformin pharmacokinetics with subsequent effects on insulin sensitivity in C57Bl/6J mice | The population-specific Thr44Met OCT3 coding variant affects metformin pharmacokinetics with subsequent effects on insulin sensitivity in C57Bl/6J mice Abstract Abstract Aims/hypothesis Metformin is an important first-line treatment for type 2 diabetes and acts by increasing the body’s ability to dispose of glucose. Me... |
PMC7110358 | core_pubmed_pmc | Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile | Genetically Modified DR5-Specific TRAIL Variant DR5-B Revealed Dual Antitumor and Protumoral Effect in Colon Cancer Xenografts and an Improved Pharmacokinetic Profile Abstract Despite the weak clinical efficacy of TRAIL death receptor agonists, a search is under way for new agents that more efficiently activate apoptot... |
PMC7752525 | core_pubmed_pmc | The Role of Stress and Genital Immunity in Sexual Trauma and HIV Susceptibility Among Adolescent Girls and Adult Women (The THRIVE Study): Protocol for a Longitudinal Case-Control Study | The Role of Stress and Genital Immunity in Sexual Trauma and HIV Susceptibility Among Adolescent Girls and Adult Women (The THRIVE Study): Protocol for a Longitudinal Case-Control Study Abstract Background The relationship between sexual violence and HIV risk has been extensively documented through social and behaviora... |
PMC5399046 | core_pubmed_pmc | Psychomotor effect differences between l -methamphetamine and d -methamphetamine are independent of murine plasma and brain pharmacokinetics profiles | Psychomotor effect differences between l -methamphetamine and d -methamphetamine are independent of murine plasma and brain pharmacokinetics profiles Abstract Abstract l -Methamphetamine has been occasionally referred to as a stimulant similar to d -methamphetamine, probably owing to insufficient comparative studies. H... |
PMC8359491 | core_pubmed_pmc | Clinical Benefit‐Risk Assessment of Nivolumab 240 mg Every 2 Weeks in Chinese Patients With Advanced and Metastatic Solid Tumors | Clinical Benefit‐Risk Assessment of Nivolumab 240 mg Every 2 Weeks in Chinese Patients With Advanced and Metastatic Solid Tumors Abstract Abstract Nivolumab 240 mg every 2 weeks is approved in China by the National Medical Product Agency for squamous cell carcinoma of the head and neck and gastric cancer, based on popu... |
PMC3629222 | core_pubmed_pmc | Design and Initial Results of a Multi-Phase Randomized Trial of Ceftriaxone in Amyotrophic Lateral Sclerosis | Design and Initial Results of a Multi-Phase Randomized Trial of Ceftriaxone in Amyotrophic Lateral Sclerosis Abstract Objectives Ceftriaxone increases expression of the astrocytic glutamate transporter, EAAT2, which might protect from glutamate-mediated excitotoxicity. A trial using a novel three stage nonstop design, ... |
PMC4334335 | core_pubmed_pmc | Factors affecting the pharmacokinetics and pharmacodynamics of PEGylated liposomal irinotecan (IHL-305) in patients with advanced solid tumors | Factors affecting the pharmacokinetics and pharmacodynamics of PEGylated liposomal irinotecan (IHL-305) in patients with advanced solid tumors Abstract Abstract IHL-305 is a PEGylated liposomal formulation of irinotecan (CPT-11). The objective of this study was to evaluate the factors associated with interpatient varia... |
PMC9907520 | core_pubmed_pmc | Pharmacokinetics of Ribavirin in the Treatment of Lassa Fever: An Observational Clinical Study at the Irrua Specialist Teaching Hospital, Edo State, Nigeria | Pharmacokinetics of Ribavirin in the Treatment of Lassa Fever: An Observational Clinical Study at the Irrua Specialist Teaching Hospital, Edo State, Nigeria Abstract Abstract Background Lassa fever is endemic in large parts of West Africa. The recommended antiviral treatment is ribavirin. Two treatment regimens are cur... |
PMC8614466 | core_pubmed_pmc | PK/PD Analysis by Nonlinear Mixed-Effects Modeling of a Marbofloxacin Dose Regimen for Treatment of Goat Mastitis Produced by Coagulase-Negative Staphylococci | PK/PD Analysis by Nonlinear Mixed-Effects Modeling of a Marbofloxacin Dose Regimen for Treatment of Goat Mastitis Produced by Coagulase-Negative Staphylococci Abstract Abstract Simple Summary Coagulase-negative staphylococci are main pathogens that produce goat mastitis. Marbofloxacin is a third-generation fluoroquinol... |
PMC9894594 | core_pubmed_pmc | Progressive Acceleration of Insulin Exposure Over 7 Days of Infusion Set Wear | Progressive Acceleration of Insulin Exposure Over 7 Days of Infusion Set Wear Abstract Abstract Insulin exposure varies over 3 days of insulin infusion set (IIS) wear making day-to-day insulin dosing challenging for people with diabetes (PWD). Here we report insulin pharmacodynamic (PD) and pharmacokinetic (PK) data ex... |
PMC5322882 | core_pubmed_pmc | Alterations in cellular pharmacokinetics and pharmacodynamics of elvitegravir in response to ethanol exposure in HIV-1 infected monocytic (U1) cells | Alterations in cellular pharmacokinetics and pharmacodynamics of elvitegravir in response to ethanol exposure in HIV-1 infected monocytic (U1) cells Abstract Abstract Ethanol consumption is negatively associated with antiretroviral therapy (ART) adherence and general health in HIV positive individuals. Previously, we d... |
PMC3218710 | core_pubmed_pmc | Safety, efficacy, and pharmacokinetics of rilpivirine: systematic review with an emphasis on resource-limited settings | Safety, efficacy, and pharmacokinetics of rilpivirine: systematic review with an emphasis on resource-limited settings Abstract Abstract The vast majority of people living with human immunodeficiency virus (HIV)/acquired immune deficiency syndrome reside in the developing world, in settings characterized by limited hea... |
PMC8070437 | core_pubmed_pmc | The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6- O -desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs | The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6- O -desmethyldonepezil, and Gastric Myoelectric Activity in Experimental Pigs Abstract Gastrointestinal side effects of donepezil, including dyspepsia, nausea, vomiting or diar... |
PMC11720699 | core_pubmed_pmc | Developing Allosteric Chaperones for GBA1 -Associated Disorders—An Integrated Computational and Experimental Approach | Developing Allosteric Chaperones for GBA1 -Associated Disorders—An Integrated Computational and Experimental Approach Abstract Abstract Mutations in the GBA1 gene, which encodes the lysosomal enzyme glucocerebrosidase (GCase), are associated with Gaucher disease and increased risk of Parkinson’s disease. This study des... |
PMC8233906 | core_pubmed_pmc | Sustained In-Vivo Release of Triptorelin Acetate from a Biodegradable Silica Depot: Comparison to Pamorelin ® LA | Sustained In-Vivo Release of Triptorelin Acetate from a Biodegradable Silica Depot: Comparison to Pamorelin ® LA Abstract Triptorelin acetate was encapsulated into silica microparticles by spray-drying a mixture of colloidal silica sol and triptorelin acetate solution. The resulting microparticles were then combined wi... |
PMC12969485 | core_pubmed_pmc | Evaluation of the management of high-risk obstetric patients living with epilepsy: A retrospective study from KwaZulu-Natal, South Africa | Evaluation of the management of high-risk obstetric patients living with epilepsy: A retrospective study from KwaZulu-Natal, South Africa Abstract Background Epilepsy affects approximately 60 million individuals worldwide, with women comprising nearly 50% of the cases. Physiological changes during pregnancy can alter a... |
PMC10322778 | core_pubmed_pmc | Management of Drug Interactions with Inducers: Onset and Disappearance of Induction on Cytochrome P450 3A4 and Uridine Diphosphate Glucuronosyltransferase 1A1 Substrates | Management of Drug Interactions with Inducers: Onset and Disappearance of Induction on Cytochrome P450 3A4 and Uridine Diphosphate Glucuronosyltransferase 1A1 Substrates Abstract Background People living with HIV may present co-morbidities requiring the initiation and subsequently the discontinuation of medications wit... |
PMC8646516 | core_pubmed_pmc | Elevated acute phase proteins affect pharmacokinetics in COVID‐19 trials: Lessons from the CounterCOVID ‐ imatinib study | Elevated acute phase proteins affect pharmacokinetics in COVID‐19 trials: Lessons from the CounterCOVID ‐ imatinib study Abstract Abstract This study aimed to determine whether published pharmacokinetic (PK) models can adequately predict the PK profile of imatinib in a new indication, such as coronavirus disease 2019 (... |
PMC9967190 | core_pubmed_pmc | A Novel Hybridization LC-MS/MS Methodology for Quantification of siRNA in Plasma, CSF and Tissue Samples | A Novel Hybridization LC-MS/MS Methodology for Quantification of siRNA in Plasma, CSF and Tissue Samples Abstract Therapeutic oligonucleotides, such as antisense oligonucleotide (ASO) and small interfering RNA (siRNA), are a new class of therapeutics rapidly growing in drug discovery and development. A sensitive and re... |
PMC9311154 | core_pubmed_pmc | Pharmacokinetics, pharmacodynamics and safety of BAY 2433334, a novel activated factor XI inhibitor, in healthy volunteers: A randomized phase 1 multiple‐dose study | Pharmacokinetics, pharmacodynamics and safety of BAY 2433334, a novel activated factor XI inhibitor, in healthy volunteers: A randomized phase 1 multiple‐dose study Abstract Abstract Aim To evaluate BAY 2433334, an oral activated factor XI (FXIa) inhibitor, in volunteers. Methods Phase 1 study of healthy men at a Germa... |
PMC12677076 | core_pubmed_pmc | Comparison of rituximab induction and maintenance regimens in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: PK/PD modelling of ANCA and gammaglobulin levels in real-world patients | Comparison of rituximab induction and maintenance regimens in anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis: PK/PD modelling of ANCA and gammaglobulin levels in real-world patients Abstract Summary Background We aimed to provide pharmacokinetic-pharmacodynamic (PK/PD) rationale for selecting the o... |
PMC12491760 | core_pubmed_pmc | Pharmacokinetic Monitoring of JAK Inhibitor and Tacrolimus for Safe and Effective Management of Graft‐Versus‐Host Disease After Pediatric Liver Transplantation | Pharmacokinetic Monitoring of JAK Inhibitor and Tacrolimus for Safe and Effective Management of Graft‐Versus‐Host Disease After Pediatric Liver Transplantation Abstract ABSTRACT Background and Aim Though liver transplantation (LT) is effective for pediatric patients with end‐stage liver disease, it is associated with c... |
PMC11743202 | core_pubmed_pmc | Quantification and prediction of human fetal (-)-Δ 9 -tetrahydrocannabinol/(±)-11-OH-Δ 9 -tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity | Quantification and prediction of human fetal (-)-Δ 9 -tetrahydrocannabinol/(±)-11-OH-Δ 9 -tetrahydrocannabinol exposure during pregnancy to inform fetal cannabis toxicity Abstract Abstract Prenatal cannabis use is associated with neurodevelopmental deficits, likely due to exposure to the psychoactive cannabinoid, (-)-Δ... |
PMC9967583 | core_pubmed_pmc | Does Aging Have an Impact on Vitamin C Status and Requirements? A Scoping Review of Comparative Studies of Aging and Institutionalisation | Does Aging Have an Impact on Vitamin C Status and Requirements? A Scoping Review of Comparative Studies of Aging and Institutionalisation Abstract Abstract The global healthcare burden of an aging population continues to increase, with nearly a quarter of the total global burden of disease attributable to people aged ≥... |
PMC4532972 | core_pubmed_pmc | A Randomized Clinical Trial of Nefopam versus Ketorolac Combined With Oxycodone in Patient-Controlled Analgesia after Gynecologic Surgery | A Randomized Clinical Trial of Nefopam versus Ketorolac Combined With Oxycodone in Patient-Controlled Analgesia after Gynecologic Surgery Abstract Abstract Objectives: Nefopam is a centrally-acting non-opioid analgesic, which has no effect on bleeding time and platelet aggregation. There has been no study about nefopam... |
PMC10232915 | core_pubmed_pmc | Multifunctional nanostructures: Intelligent design to overcome biological barriers | Multifunctional nanostructures: Intelligent design to overcome biological barriers Abstract Over the past three decades, nanoscience has offered a unique solution for reducing the systemic toxicity of chemotherapy drugs and for increasing drug therapeutic efficiency. However, the poor accumulation and pharmacokinetics ... |
PMC5384948 | core_pubmed_pmc | Levodopa/carbidopa microtablets in Parkinson’s disease: a study of pharmacokinetics and blinded motor assessment | Levodopa/carbidopa microtablets in Parkinson’s disease: a study of pharmacokinetics and blinded motor assessment Abstract Abstract Background Motor function assessments with rating scales in relation to the pharmacokinetics of levodopa may increase the understanding of how to individualize and fine-tune treatments. Obj... |
PMC7907604 | core_pubmed_pmc | Clinical Pharmacokinetics of Enalapril and Enalaprilat in Pediatric Patients—A Systematic Review | Clinical Pharmacokinetics of Enalapril and Enalaprilat in Pediatric Patients—A Systematic Review Abstract Abstract Purpose: Enalapril has an established safety and efficacy in adults and is used in hypertension, heart failure, and renal failure. In pediatric patients, enalapril is labeled for children with hypertension... |
PMC11754916 | core_pubmed_pmc | Identification of promising SARS-CoV-2 main protease inhibitor through molecular docking, dynamics simulation, and ADMET analysis | Identification of promising SARS-CoV-2 main protease inhibitor through molecular docking, dynamics simulation, and ADMET analysis Abstract The COVID-19 pandemic caused by SARS-CoV-2 continues to pose a major challenge to global health. Targeting the main protease of the virus (Mpro), which is essential for viral replic... |
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