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PMC8825669 | core_pubmed_pmc | Model-Based Efficacy and Toxicity Comparisons of Moxifloxacin for Multidrug-Resistant Tuberculosis | Model-Based Efficacy and Toxicity Comparisons of Moxifloxacin for Multidrug-Resistant Tuberculosis Abstract Abstract Background Moxifloxacin (MOX) is used as a first-choice drug to treat multidrug-resistant tuberculosis (MDR-TB); however, evidence-based dosing optimization should be strengthened by integrative analysis... |
PMC9395533 | core_pubmed_pmc | Estimating the time of last drinking from blood ethyl glucuronide and ethyl sulphate concentrations | Estimating the time of last drinking from blood ethyl glucuronide and ethyl sulphate concentrations Abstract The determination of length of time from the last drinking is critical for cases like drunk driving, sexual assault victims, and also postmortem suspected poisoning cases. The study was aimed to established a me... |
PMC9466465 | core_pubmed_pmc | Population pharmacokinetic study of pemetrexed in chinese primary advanced non-small cell lung carcinoma patients | Population pharmacokinetic study of pemetrexed in chinese primary advanced non-small cell lung carcinoma patients Abstract The purposes of this study were to identify physiological and genetic factors that contributed to variability of pemetrexed (PEM) exposure and to optimize the dosing regimens for Chinese non-small ... |
PMC9401487 | core_pubmed_pmc | Ceralasertib (AZD6738), an Oral ATR Kinase Inhibitor, in Combination with Carboplatin in Patients with Advanced Solid Tumors: A Phase I Study | Ceralasertib (AZD6738), an Oral ATR Kinase Inhibitor, in Combination with Carboplatin in Patients with Advanced Solid Tumors: A Phase I Study Abstract Abstract Purpose: This study reports the safety, tolerability, MTD, recommended phase II dose (RP2D), pharmacokinetic/pharmacodynamic profile, and preliminary antitumor ... |
PMC5168502 | core_pubmed_pmc | Understanding Lung Deposition of Alpha-1 Antitrypsin in Acute Experimental Mouse Lung Injury Model Using Fluorescence Microscopy | Understanding Lung Deposition of Alpha-1 Antitrypsin in Acute Experimental Mouse Lung Injury Model Using Fluorescence Microscopy Abstract Abstract Human plasma-derived α 1-antitrypsin (AAT) delivered by intravenous infusion is used as augmentation therapy in patients with emphysema who have a genetic mutation resulting... |
PMC12148590 | core_pubmed_pmc | Sex differences in discontinuations due to side effects of second-generation integrase strand transfer inhibitors: a systematic review and meta-analysis | Sex differences in discontinuations due to side effects of second-generation integrase strand transfer inhibitors: a systematic review and meta-analysis Abstract Summary Background Dolutegravir and bictegravir are frequently prescribed second-generation integrase strand transfer inhibitors. Although sex and gender infl... |
PMC4987402 | core_pubmed_pmc | Pharmacokinetic Bioequivalence of Two Inhaled Tiotropium Bromide Formulations in Healthy Volunteers | Pharmacokinetic Bioequivalence of Two Inhaled Tiotropium Bromide Formulations in Healthy Volunteers Abstract Abstract Background and Objective A novel tiotropium bromide monodose capsule dry powder inhaler (DPI) formulation and device have been developed. The formulation was based on a spray-dried matrix that enhances ... |
PMC7884679 | core_pubmed_pmc | A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours | A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours Abstract Background This open-label, phase 1 trial ( NCT02316197 ) aimed to determine the maximum-tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of peposertib (form... |
PMC7032169 | core_pubmed_pmc | Preparation and in vitro-in vivo evaluation of intestinal retention pellets of Berberine chloride to enhance hypoglycemic and lipid-lowing efficacy | Preparation and in vitro-in vivo evaluation of intestinal retention pellets of Berberine chloride to enhance hypoglycemic and lipid-lowing efficacy Abstract Abstract Berberine chloride (BBR) is a pharmacokinetic profile of drug with poor bioavailability but good therapeutic efficacy, which is closely related to the dis... |
PMC8761718 | core_pubmed_pmc | Characterization of the Population Pharmacokinetics of Moxidectin in Adults Infected with Strongyloides Stercoralis : Support for a Fixed-Dose Treatment Regimen | Characterization of the Population Pharmacokinetics of Moxidectin in Adults Infected with Strongyloides Stercoralis : Support for a Fixed-Dose Treatment Regimen Abstract Abstract Background Moxidectin has recently attracted attention as a novel candidate for the treatment of helminth infections, including Strongyloides... |
PMC7152953 | core_pubmed_pmc | Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MS/MS | Pharmacokinetic Comparisons of Naringenin and Naringenin-Nicotinamide Cocrystal in Rats by LC-MS/MS Abstract Abstract Naringenin (NAR), 4′,5,7-trihydroxydihydroflavone, has a wide range of pharmacological activities but shows poor water solubility and low bioavailability. The pharmacokinetics and bioavailability of nar... |
PMC8249265 | core_pubmed_pmc | Glomerular Filtration Rate in Asphyxiated Neonates Under Therapeutic Whole-Body Hypothermia, Quantified by Mannitol Clearance | Glomerular Filtration Rate in Asphyxiated Neonates Under Therapeutic Whole-Body Hypothermia, Quantified by Mannitol Clearance Abstract Background Therapeutic hypothermia (TH) is an established intervention to improve the outcome of neonates with moderate-to-severe hypoxic-ischemic encephalopathy resulting from perinata... |
PMC5826151 | core_pubmed_pmc | Relation between Skin Pharmacokinetics and Efficacy in AmBisome Treatment of Murine Cutaneous Leishmaniasis | Relation between Skin Pharmacokinetics and Efficacy in AmBisome Treatment of Murine Cutaneous Leishmaniasis Abstract ABSTRACT AmBisome (LAmB), a liposomal formulation of amphotericin B (AmB), is a second-line treatment for the parasitic skin disease cutaneous leishmaniasis (CL). Little is known about its tissue distrib... |
PMC6150481 | core_pubmed_pmc | Structural basis of antiviral activity of peptides from MPER of FIV gp36 | Structural basis of antiviral activity of peptides from MPER of FIV gp36 Abstract Abstract Feline immunodeficiency virus (FIV) is a naturally occurring Lentivirus causing acquired immunodeficiency syndrome in felines. It is considered a useful non-primate model to study HIV infection, and to test anti-HIV vaccine. Simi... |
PMC11770325 | core_pubmed_pmc | Evaluation of the Effect of Loperamide on the Cardiac Repolarization Interval Using Exposure–Response Analysis | Evaluation of the Effect of Loperamide on the Cardiac Repolarization Interval Using Exposure–Response Analysis Abstract ABSTRACT This analysis assessed the relationship between the plasma concentrations of loperamide and its N ‐desmethyl loperamide meta‐ bolite (M1) and the potential QT interval prolongation at therape... |
PMC10962649 | core_pubmed_pmc | An acute herb–drug interaction of Magnoliae Officinalis Cortex with methotrexate via inhibiting multidrug resistance-associated protein 2 | An acute herb–drug interaction of Magnoliae Officinalis Cortex with methotrexate via inhibiting multidrug resistance-associated protein 2 Abstract Abstract Magnoliae Officinalis Cortex (MOC), an herbal drug, contains polyphenolic lignans mainly magnolol (MN) and honokiol (HK). Methotrexate (MTX), a critical drug for ca... |
PMC9283737 | core_pubmed_pmc | Bioequivalence of two oral formulations of tebipenem pivoxil hydrobromide in healthy subjects | Bioequivalence of two oral formulations of tebipenem pivoxil hydrobromide in healthy subjects Abstract Abstract Tebipenem pivoxil hydrobromide (TBP‐PI‐HBr) is a novel oral carbapenem prodrug of tebipenem (TBP), the active moiety, currently in development for treating serious bacterial infections. This study assessed th... |
PMC11646940 | core_pubmed_pmc | Local depletion of large molecule drugs due to target binding in tissue interstitial space | Local depletion of large molecule drugs due to target binding in tissue interstitial space Abstract Abstract Drug–target binding determines a drug's pharmacodynamics but can also have a profound impact on a drug's pharmacokinetics, known as target‐mediated drug disposition (TMDD). TMDD models describe the influence of ... |
PMC4418344 | core_pubmed_pmc | Population Pharmacokinetics of Pomalidomide | Population Pharmacokinetics of Pomalidomide Abstract A population pharmacokinetic (PPK) model of pomalidomide was developed and the influence of demographic and disease-related covariates on PPK parameters was assessed based on data from 6 clinical trials of pomalidomide (dose range, 0.5–10 mg) in healthy participants ... |
PMC7459987 | core_pubmed_pmc | Pharmacokinetics of a Long-Acting Formulation of Oxytetracycline in Freshwater Crocodiles ( Crocodylus siamensis ) after Intramuscular Administration at Three Different Dosages | Pharmacokinetics of a Long-Acting Formulation of Oxytetracycline in Freshwater Crocodiles ( Crocodylus siamensis ) after Intramuscular Administration at Three Different Dosages Abstract Simple Summary The oxytetracycline long-acting formulation (OTC-LA) is used to treat sensitive pathogenic bacteria in the freshwater c... |
PMC6470992 | core_pubmed_pmc | Pharmacokinetics of a New Pharmaceutical Form of Vitamin D3 100,000 IU in Soft Capsule | Pharmacokinetics of a New Pharmaceutical Form of Vitamin D3 100,000 IU in Soft Capsule Abstract Vitamin D deficiency is frequent in the general population and both subjects and health professionals could benefit from a broader range of vitamin D3 formulations. We conducted a single-dose, open-label, parallel-group, ran... |
PMC8932692 | core_pubmed_pmc | Population pharmacokinetics and exposure‐response modeling analyses of guselkumab in patients with psoriatic arthritis | Population pharmacokinetics and exposure‐response modeling analyses of guselkumab in patients with psoriatic arthritis Abstract Abstract Guselkumab is an anti‐interleukin‐23 human monoclonal antibody effective in treating psoriatic arthritis (PsA). To characterize the pharmacokinetics (PKs) and exposure‐response relati... |
PMC4467585 | core_pubmed_pmc | Phase I Study of Ceritinib (LDK378) in Japanese Patients with Advanced, Anaplastic Lymphoma Kinase-Rearranged Non–Small-Cell Lung Cancer or Other Tumors | Phase I Study of Ceritinib (LDK378) in Japanese Patients with Advanced, Anaplastic Lymphoma Kinase-Rearranged Non–Small-Cell Lung Cancer or Other Tumors Abstract Abstract Introduction: Anaplastic lymphoma kinase (ALK)-rearranged non–small-cell lung cancer (NSCLC) is sensitive to ALK inhibitors, but resistance develops.... |
PMC7049745 | core_pubmed_pmc | Comparative Assessment of Distribution Characteristics and Ocular Pharmacokinetics of Norvancomycin Between Continuous Topical Ocular Instillation and Hourly Administration of Eye Drop | Comparative Assessment of Distribution Characteristics and Ocular Pharmacokinetics of Norvancomycin Between Continuous Topical Ocular Instillation and Hourly Administration of Eye Drop Abstract Background The aim of this study was to compare the distribution characteristics and ocular pharmacokinetics of norvancomycin ... |
PMC8550258 | core_pubmed_pmc | Characterization of Plasma Protein Alterations in Pregnant and Postpartum Individuals Living With HIV to Support Physiologically-Based Pharmacokinetic Model Development | Characterization of Plasma Protein Alterations in Pregnant and Postpartum Individuals Living With HIV to Support Physiologically-Based Pharmacokinetic Model Development Abstract Background: Alterations in plasma protein concentrations in pregnant and postpartum individuals can influence antiretroviral (ARV) pharmacokin... |
PMC9020367 | core_pubmed_pmc | Race and sex associations with tacrolimus pharmacokinetics in stable kidney transplant recipients | Race and sex associations with tacrolimus pharmacokinetics in stable kidney transplant recipients Abstract Abstract Study Objective This study investigated race and sex differences in tacrolimus pharmacokinetics and pharmacodynamics in stable kidney transplant recipients. Design and Setting A cross‐sectional, open‐labe... |
PMC7147088 | core_pubmed_pmc | First-in-human study of anticancer immunotherapy drug candidate mobilan: safety, pharmacokinetics and pharmacodynamics in prostate cancer patients | First-in-human study of anticancer immunotherapy drug candidate mobilan: safety, pharmacokinetics and pharmacodynamics in prostate cancer patients Abstract Toll-like receptor 5 (TLR5) controls endogenous immune responses to pathogens and is a promising target for pharmacological stimulation of anti-tumor immunity. Mobi... |
PMC12349950 | core_pubmed_pmc | Population Pharmacokinetics of Rifampicin in Plasma and Cerebrospinal Fluid in Adults With Tuberculosis Meningitis | Population Pharmacokinetics of Rifampicin in Plasma and Cerebrospinal Fluid in Adults With Tuberculosis Meningitis Abstract Abstract Background Several ongoing clinical trials are evaluating high-dose rifampicin (up to 35 mg/kg) for tuberculous meningitis (TBM). However, rifampicin pharmacokinetics at higher doses is n... |
PMC8808076 | core_pubmed_pmc | High doses of favipiravir in two men survivors of Ebola virus disease carrying Ebola virus in semen in Guinea | High doses of favipiravir in two men survivors of Ebola virus disease carrying Ebola virus in semen in Guinea Abstract Abstract Background Persistence of Ebola virus (EBOV) in semen remains of deep concern, as sexual transmission of EBOV seems plausible up to 6 months after acute phase of Ebola virus disease (EVD). Fav... |
PMC7536163 | core_pubmed_pmc | Direct comparison of two extended half-life PEGylated recombinant FVIII products: a randomized, crossover pharmacokinetic study in patients with severe hemophilia A | Direct comparison of two extended half-life PEGylated recombinant FVIII products: a randomized, crossover pharmacokinetic study in patients with severe hemophilia A Abstract An open-label, crossover randomized study was performed to compare the pharmacokinetics (PK) of damoctocog alfa pegol and rurioctocog alfa pegol, ... |
PMC10796587 | core_pubmed_pmc | Nimodipine systemic exposure and outcomes following aneurysmal subarachnoid hemorrhage: a pilot prospective observational study (ASH-1 study) | Nimodipine systemic exposure and outcomes following aneurysmal subarachnoid hemorrhage: a pilot prospective observational study (ASH-1 study) Abstract Abstract Background Nimodipine improves outcomes following aneurysmal subarachnoid hemorrhage (aSAH). Guidelines recommend that all patients should receive a fixed-dose ... |
PMC12777563 | core_pubmed_pmc | Population pharmacokinetics and optimized dosing of piperacillin-tazobactam in hematological patients with febrile neutropenia | Population pharmacokinetics and optimized dosing of piperacillin-tazobactam in hematological patients with febrile neutropenia Abstract ABSTRACT Hematological patients with febrile neutropenia receiving piperacillin-tazobactam may experience pharmacokinetic alterations that compromise drug exposure. We aimed to charact... |
PMC8637767 | core_pubmed_pmc | Multimodal Imaging Technology Effectively Monitors HER2 Expression in Tumors Using Trastuzumab-Coupled Organic Nanoparticles in Patient-Derived Xenograft Mice Models | Multimodal Imaging Technology Effectively Monitors HER2 Expression in Tumors Using Trastuzumab-Coupled Organic Nanoparticles in Patient-Derived Xenograft Mice Models Abstract Abstract Trastuzumab is a monoclonal antibody targeting human epidermal growth factor 2 (HER2), which has been successfully used in the treatment... |
PMC10985906 | core_pubmed_pmc | Anticholinesterase activities of novel isoindolin-1,3-dione-based acetohydrazide derivatives: design, synthesis, biological evaluation, molecular dynamic study | Anticholinesterase activities of novel isoindolin-1,3-dione-based acetohydrazide derivatives: design, synthesis, biological evaluation, molecular dynamic study Abstract In pursuit of developing novel cholinesterase (ChE) inhibitors through molecular hybridization theory, a novel series of isoindolin-1,3-dione-based ace... |
PMC8518673 | core_pubmed_pmc | Evaluation of Pharmacokinetics, Safety, and Drug‐Drug Interactions of an Oral Suspension of Edaravone in Healthy Adults | Evaluation of Pharmacokinetics, Safety, and Drug‐Drug Interactions of an Oral Suspension of Edaravone in Healthy Adults Abstract Abstract Intravenous (IV) edaravone is approved as an amyotrophic lateral sclerosis (ALS) treatment. Because IV administration places a burden on patients, development of orally administered ... |
PMC4446576 | core_pubmed_pmc | A Novel Simultaneous Determination of Sarpogrelate and its Active Metabolite (M-1) in Human Plasma, Using Liquid Chromatography-Tandem Mass Spectrometry: Clinical Application | A Novel Simultaneous Determination of Sarpogrelate and its Active Metabolite (M-1) in Human Plasma, Using Liquid Chromatography-Tandem Mass Spectrometry: Clinical Application Abstract Background This study describes a novel analytical method for simultaneously determining sarpogrelate and its metabolite (M-1) in human ... |
PMC9202863 | core_pubmed_pmc | Permeability of dopamine D2 receptor agonist hordenine across the intestinal and blood-brain barrier in vitro | Permeability of dopamine D2 receptor agonist hordenine across the intestinal and blood-brain barrier in vitro Abstract Abstract Hordenine, a bioactive food compound, has several pharmacological properties and has recently been identified as a dopamine D2 receptor (D2R) agonist. Since the pharmacokinetic profile of hord... |
PMC12842855 | core_pubmed_pmc | Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men | Pharmacokinetics, pharmacodynamics, and safety interaction study of tunodafil hydrochloride and alcohol: A randomized, blinded, placebo‐controlled, three‐cycle crossover study in Chinese healthy men Abstract Abstract Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochl... |
PMC10690594 | core_pubmed_pmc | A mechanism-based pathway toward administering highly active N-phage cocktails | A mechanism-based pathway toward administering highly active N-phage cocktails Abstract Abstract Bacteriophage (phage) therapy is being explored as a possible response to the antimicrobial resistance public health emergency. Administering a mixture of different phage types as a cocktail is one proposed strategy for the... |
PMC6020478 | core_pubmed_pmc | Efficacy of Nivolumab in a Patient with Metastatic Renal Cell Carcinoma and End-Stage Renal Disease on Dialysis: Case Report and Literature Review | Efficacy of Nivolumab in a Patient with Metastatic Renal Cell Carcinoma and End-Stage Renal Disease on Dialysis: Case Report and Literature Review Abstract Abstract Treatment of patients with metastatic renal cell carcinoma (mRCC) and end-stage renal disease (ESRD) on dialysis poses a therapeutic challenge, particularl... |
PMC10692660 | core_pubmed_pmc | A pilot study of the pharmacokinetics of continuous magnesium infusion in critically ill patients | A pilot study of the pharmacokinetics of continuous magnesium infusion in critically ill patients Abstract Objective: The pharmacokinetics and haemodynamic effect of continuous magnesium infusion in non-cardiac intensive care unit (ICU) patients are poorly understood. We aimed to measure serum and urine magnesium level... |
PMC11993281 | core_pubmed_pmc | Dose‐Optimization of a Novel Co‐Formulated Triple Combination Antimalarial Therapy: Artemether‐Lumefantrine‐Amodiaquine | Dose‐Optimization of a Novel Co‐Formulated Triple Combination Antimalarial Therapy: Artemether‐Lumefantrine‐Amodiaquine Abstract Abstract Artemisinin‐based combination therapy (ACT) is the first‐line therapy for uncomplicated falciparum malaria, but artemisinin resistance in Asia and now sub‐Saharan Africa is threateni... |
PMC3405235 | core_pubmed_pmc | Effect of abiraterone acetate plus prednisone on the QT interval in patients with metastatic castration-resistant prostate cancer | Effect of abiraterone acetate plus prednisone on the QT interval in patients with metastatic castration-resistant prostate cancer Abstract Abstract Purpose Abiraterone is the active metabolite of the pro-drug abiraterone acetate (AA) and a selective inhibitor of CYP17, a key enzyme in testosterone synthesis, and improv... |
PMC10191279 | core_pubmed_pmc | Interspecies evaluation of a physiologically based pharmacokinetic model to predict the biodistribution dynamics of dendritic nanoparticles | Interspecies evaluation of a physiologically based pharmacokinetic model to predict the biodistribution dynamics of dendritic nanoparticles Abstract Abstract The exposure of a dendritic nanoparticle and its conjugated active pharmaceutical ingredient (API) was determined in mouse, rat and dog, with the aim of investiga... |
PMC12502012 | core_pubmed_pmc | Site‐Specific Antithrombotic Therapy: 24‐Month Outcomes of the Randomized DESyne BDS Plus Trial Using a Novel Triple‐Drug Eluting Coronary Implant With Two Anticoagulants and Sirolimus | Site‐Specific Antithrombotic Therapy: 24‐Month Outcomes of the Randomized DESyne BDS Plus Trial Using a Novel Triple‐Drug Eluting Coronary Implant With Two Anticoagulants and Sirolimus Abstract ABSTRACT Background DESyne BDS Plus represents a novel triple drug therapy (TRx) applied on a coronary stent platform eluting ... |
PMC10349714 | core_pubmed_pmc | Neuroprotective and nephroprotective effects of Ircinia sponge in polycyclic aromatic hydrocarbons (PAHs) induced toxicity in animal model: a pharmacological and computational approach | Neuroprotective and nephroprotective effects of Ircinia sponge in polycyclic aromatic hydrocarbons (PAHs) induced toxicity in animal model: a pharmacological and computational approach Abstract The present study investigated the neuroprotective and nephroprotective effects of the sponge Ircinia sp. ethyl acetate extrac... |
PMC7151106 | core_pubmed_pmc | Comparative Pharmacokinetics and Pharmacodynamics of a Novel Sodium-Glucose Cotransporter 2 Inhibitor, DWP16001, with Dapagliflozin and Ipragliflozin | Comparative Pharmacokinetics and Pharmacodynamics of a Novel Sodium-Glucose Cotransporter 2 Inhibitor, DWP16001, with Dapagliflozin and Ipragliflozin Abstract Since sodium-glucose cotransporter 2 (SGLT2) inhibitors reduced blood glucose level by inhibiting renal tubular glucose reabsorption mediated by SGLT2, we aimed ... |
PMC6138480 | core_pubmed_pmc | In vivo affinity and target engagement in skin and blood in a first‐time‐in‐human study of an anti‐oncostatin M monoclonal antibody | In vivo affinity and target engagement in skin and blood in a first‐time‐in‐human study of an anti‐oncostatin M monoclonal antibody Abstract Abstract Aims The oncostatin M (OSM) pathway drives fibrosis, inflammation and vasculopathy, and is a potential therapeutic target for inflammatory and fibrotic diseases. The aim ... |
PMC9755920 | core_pubmed_pmc | Applying interpretable machine learning workflow to evaluate exposure–response relationships for large‐molecule oncology drugs | Applying interpretable machine learning workflow to evaluate exposure–response relationships for large‐molecule oncology drugs Abstract Abstract The application of logistic regression (LR) and Cox Proportional Hazard (CoxPH) models are well‐established for evaluating exposure–response (E–R) relationship in large molecu... |
PMC9123906 | core_pubmed_pmc | Effects of Ethanolic Extract of Schisandra sphenanthera on the Pharmacokinetics of Rosuvastatin in Rats | Effects of Ethanolic Extract of Schisandra sphenanthera on the Pharmacokinetics of Rosuvastatin in Rats Abstract Purpose Wuzhi capsule (WZ) is a proprietary Chinese medicine prepared from the ethanolic extract of Schisandra sphenanthera that is commonly used to treat liver injury. Statins are widely used in patients wi... |
PMC11360071 | core_pubmed_pmc | Pharmacokinetic Simulation and Area under the Curve Estimation of Drugs Subject to Enterohepatic Circulation | Pharmacokinetic Simulation and Area under the Curve Estimation of Drugs Subject to Enterohepatic Circulation Abstract Abstract Enterohepatic circulation (EHC) is a complex process where drugs undergo secretion and reabsorption from the intestinal lumen multiple times, resulting in pharmacokinetic profiles with multiple... |
PMC7487994 | core_pubmed_pmc | Navafenterol (AZD8871) in patients with mild asthma: a randomised placebo-controlled phase I study evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending doses of this novel inhaled long-acting dual-pharmacology bronchodilator | Navafenterol (AZD8871) in patients with mild asthma: a randomised placebo-controlled phase I study evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending doses of this novel inhaled long-acting dual-pharmacology bronchodilator Abstract Abstract Background Navafenterol (AZD8871) ... |
PMC10990017 | core_pubmed_pmc | The novel rapid formulation of intravenous dantrolene (NPJ5008) versus standard dantrolene (Dantrium®) | The novel rapid formulation of intravenous dantrolene (NPJ5008) versus standard dantrolene (Dantrium®) Abstract Abstract BACKGROUND Delays in treating anaesthesia-induced malignant hyperthermia increase risks of complications and death. NPJ5008 is a novel formulation of the indicated treatment, dantrolene sodium, devel... |
PMC9411916 | core_pubmed_pmc | Randomised controlled trial of fosfomycin in neonatal sepsis: pharmacokinetics and safety in relation to sodium overload | Randomised controlled trial of fosfomycin in neonatal sepsis: pharmacokinetics and safety in relation to sodium overload Abstract Objective To assess pharmacokinetics and changes to sodium levels in addition to adverse events (AEs) associated with fosfomycin among neonates with clinical sepsis. Design A single-centre o... |
PMC11251614 | core_pubmed_pmc | Pharmacokinetics of isavuconazonium sulfate and its active metabolite isavuconazole in healthy dogs | Pharmacokinetics of isavuconazonium sulfate and its active metabolite isavuconazole in healthy dogs Abstract Abstract Invasive fungal infections (IFIs) are growing in importance in veterinary and human medicine. IFIs such as aspergillosis, blastomycosis, coccidioidomycosis and histoplasmosis remain challenging to treat... |
PMC12631411 | core_pubmed_pmc | A Comprehensive Review of Medicarpin: A Phytoalexin with Therapeutic Potential | A Comprehensive Review of Medicarpin: A Phytoalexin with Therapeutic Potential Abstract Initially, research on medicarpin focused on its role in crop protection, including gene modifications, allelopathic effects, antifungal potential, and biosynthetic mechanisms. Later, various biological activities were demonstrated ... |
PMC10892536 | core_pubmed_pmc | Establishment and Validation of a Transdermal Drug Delivery System for the Anti-Depressant Drug Citalopram Hydrobromide | Establishment and Validation of a Transdermal Drug Delivery System for the Anti-Depressant Drug Citalopram Hydrobromide Abstract To enhance the bioavailability and antihypertensive effect of the anti-depressant drug citalopram hydrobromide (CTH) we developed a sustained-release transdermal delivery system containing CT... |
PMC6669232 | core_pubmed_pmc | Effects of Comedication and Genetic Factors on the Population Pharmacokinetics of Lamotrigine: A Prospective Analysis in Chinese Patients With Epilepsy | Effects of Comedication and Genetic Factors on the Population Pharmacokinetics of Lamotrigine: A Prospective Analysis in Chinese Patients With Epilepsy Abstract Abstract Lamotrigine (LTG) is a second-generation anti-epileptic drug widely used for focal and generalized seizures in adults and children, and as a first-lin... |
PMC3852160 | core_pubmed_pmc | PKPD Modeling of VEGF, sVEGFR-2, sVEGFR-3, and sKIT as Predictors of Tumor Dynamics and Overall Survival Following Sunitinib Treatment in GIST | PKPD Modeling of VEGF, sVEGFR-2, sVEGFR-3, and sKIT as Predictors of Tumor Dynamics and Overall Survival Following Sunitinib Treatment in GIST Abstract The predictive value of longitudinal biomarker data (vascular endothelial growth factor (VEGF), soluble VEGF receptor (sVEGFR)-2, sVEGFR-3, and soluble stem cell factor... |
PMC4631180 | core_pubmed_pmc | Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen | Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen Abstract Aims The antiviral agent favipiravir is likely to be co‐prescribed with acetaminophen (paracetamol). The present study evaluated the possiblility of a pharmacokinetic interaction between favipi... |
PMC5444153 | core_pubmed_pmc | Efficacy, Safety, and Tolerability of Gepotidacin (GSK2140944) in the Treatment of Patients with Suspected or Confirmed Gram-Positive Acute Bacterial Skin and Skin Structure Infections | Efficacy, Safety, and Tolerability of Gepotidacin (GSK2140944) in the Treatment of Patients with Suspected or Confirmed Gram-Positive Acute Bacterial Skin and Skin Structure Infections Abstract ABSTRACT Gepotidacin is a novel, first-in-class, triazaacenaphthylene antibacterial agent which has in vitro activity against ... |
PMC7433713 | core_pubmed_pmc | Beyond Single Nucleotide Polymorphisms: CYP3A5 ∗ 3 ∗ 6 ∗ 7 Composite and ABCB1 Haplotype Associations to Tacrolimus Pharmacokinetics in Black and White Renal Transplant Recipients | Beyond Single Nucleotide Polymorphisms: CYP3A5 ∗ 3 ∗ 6 ∗ 7 Composite and ABCB1 Haplotype Associations to Tacrolimus Pharmacokinetics in Black and White Renal Transplant Recipients Abstract Abstract Interpatient variability in tacrolimus pharmacokinetics is attributed to metabolism by cytochrome P-450 3A5 (CYP3A5) isoen... |
PMC9588345 | core_pubmed_pmc | Mechanisms Underlying the Differences in the Pharmacokinetics of Six Active Constituents of Huangqi Liuyi Decoction between Normal and Diabetic Nephropathy Mouse Models | Mechanisms Underlying the Differences in the Pharmacokinetics of Six Active Constituents of Huangqi Liuyi Decoction between Normal and Diabetic Nephropathy Mouse Models Abstract The aim of this study was to explore the mechanisms underlying the differences in the pharmacokinetics of Huangqi Liuyi decoction extract (HQD... |
PMC5431384 | core_pubmed_pmc | Human Abuse Potential of an Abuse-Deterrent (AD), Extended-Release (ER) Morphine Product Candidate (Morphine-ADER Injection-Molded Tablets) versus Extended-Release Morphine Administered Orally in Nondependent Recreational Opioid Users | Human Abuse Potential of an Abuse-Deterrent (AD), Extended-Release (ER) Morphine Product Candidate (Morphine-ADER Injection-Molded Tablets) versus Extended-Release Morphine Administered Orally in Nondependent Recreational Opioid Users Abstract Objective . To compare the relative human abuse potential of intact and mani... |
PMC6134777 | core_pubmed_pmc | Cefepime dosing regimens in critically ill patients receiving continuous renal replacement therapy: a Monte Carlo simulation study | Cefepime dosing regimens in critically ill patients receiving continuous renal replacement therapy: a Monte Carlo simulation study Abstract Background Cefepime can be removed by continuous renal replacement therapy (CRRT) due to its pharmacokinetics. The purpose of this study is to define the optimal cefepime dosing re... |
PMC9275503 | core_pubmed_pmc | Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization | Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization Abstract Abstract Isoliquiritigenin (ISL), as a natural flavonoid, has been proven to have therapeutic potential for corneal neovascularization (CNV) treatment; however,... |
PMC6271955 | core_pubmed_pmc | Pharmacokinetics of BMEDA after Intravenous Administration in Beagle Dogs | Pharmacokinetics of BMEDA after Intravenous Administration in Beagle Dogs Abstract The pharmacokinetics of N , N -bis(2-mercapatoethly)- N ', N '-diethylenediamine (BMEDA), a molecule that can form a chelate with rhenium-188 ( 188 Re) to produce the 188 Re-BMEDA-liposomes, was studied. In this work, beagles received a ... |
PMC8212730 | core_pubmed_pmc | Population pharmacokinetic and exposure‐response analyses of ivosidenib in patients with IDH1 ‐mutant advanced hematologic malignancies | Population pharmacokinetic and exposure‐response analyses of ivosidenib in patients with IDH1 ‐mutant advanced hematologic malignancies Abstract Abstract Ivosidenib is a once daily (q.d.), orally available, potent mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor approved for treatment of patients with relapsed or re... |
PMC8464239 | core_pubmed_pmc | Pharmacokinetics of zonisamide after oral single dosing and multiple‐dose escalation administration in domestic chickens ( Gallus gallus ) | Pharmacokinetics of zonisamide after oral single dosing and multiple‐dose escalation administration in domestic chickens ( Gallus gallus ) Abstract Abstract Background There are few effective drugs for treatment of seizures in avian species. Objectives To investigate the pharmacokinetics and safety of zonisamide in chi... |
PMC10525795 | core_pubmed_pmc | Pharmacokinetics of Four Tyrosine Kinase Inhibitors in Adult and Paediatric Chronic Myeloid Leukaemia Patients | Pharmacokinetics of Four Tyrosine Kinase Inhibitors in Adult and Paediatric Chronic Myeloid Leukaemia Patients Abstract Tyrosine kinase inhibitors work by blocking the tyrosine kinases responsible for the dysregulation of intracellular signalling pathways in tumour cells. This study looked at the impact of age and sex ... |
PMC11807123 | core_pubmed_pmc | Development of highly bioactive long-acting recombinant porcine FSH for batch production management of sows | Development of highly bioactive long-acting recombinant porcine FSH for batch production management of sows Abstract To improve the economic benefits, exogenous hormones are used to control follicular development and synchronize ovulation in the batch flow management of gilts and weaned sows. Equine chorionic gonadotro... |
PMC6466385 | core_pubmed_pmc | A Three-Compartment Pharmacokinetic Model to Predict the Interstitial Concentration of Talaporfin Sodium in the Myocardium for Photodynamic Therapy: A Method Combining Measured Fluorescence and Analysis of the Compartmental Origin of the Fluorescence | A Three-Compartment Pharmacokinetic Model to Predict the Interstitial Concentration of Talaporfin Sodium in the Myocardium for Photodynamic Therapy: A Method Combining Measured Fluorescence and Analysis of the Compartmental Origin of the Fluorescence Abstract Abstract To evaluate the effectiveness of photodynamic thera... |
PMC9572380 | core_pubmed_pmc | Effect of Hydrophilic Polymers on the Release Rate and Pharmacokinetics of Acyclovir Tablets Obtained by Wet Granulation: In Vitro and In Vivo Assays | Effect of Hydrophilic Polymers on the Release Rate and Pharmacokinetics of Acyclovir Tablets Obtained by Wet Granulation: In Vitro and In Vivo Assays Abstract This study aims to evaluate the feasibility of producing acyclovir-containing modified release matrix tablets by a wet granulation method based on the type and c... |
PMC10237096 | core_pubmed_pmc | Assessment of delayed bleeding after endoscopic submucosal dissection of early-stage gastrointestinal tumors in patients receiving direct oral anticoagulants | Assessment of delayed bleeding after endoscopic submucosal dissection of early-stage gastrointestinal tumors in patients receiving direct oral anticoagulants Abstract Delayed bleeding is a major and serious adverse event of endoscopic submucosal dissection (ESD) for early-stage gastrointestinal tumors. The rate of post... |
PMC10620511 | core_pubmed_pmc | In vitro to clinical translation of combinatorial effects of doxorubicin and dexrazoxane in breast cancer: a mechanism-based pharmacokinetic/pharmacodynamic modeling approach | In vitro to clinical translation of combinatorial effects of doxorubicin and dexrazoxane in breast cancer: a mechanism-based pharmacokinetic/pharmacodynamic modeling approach Abstract Abstract Dexrazoxane (DEX) is the only drug clinically approved to treat Doxorubicin-induced cardiotoxicity (DIC), however its impact on... |
PMC11912929 | core_pubmed_pmc | Bioequivalence Study of Single-Pill Capsule Formulation of Amlodipine Plus Benazepril in Healthy Chinese Subjects Under Fasting and Fed Conditions | Bioequivalence Study of Single-Pill Capsule Formulation of Amlodipine Plus Benazepril in Healthy Chinese Subjects Under Fasting and Fed Conditions Abstract Abstract Background The aim of the study was to evaluate the pharmacokinetic (PK) properties and safety profiles of test and reference amlodipine/benazepril capsule... |
PMC6615023 | core_pubmed_pmc | Elaboration and characterization of curcumin-loaded Tri-CL-mPEG three-arm copolymeric nanoparticles by a microchannel technology | Elaboration and characterization of curcumin-loaded Tri-CL-mPEG three-arm copolymeric nanoparticles by a microchannel technology Abstract Abstract Purpose: Clinical applications of curcumin (Cur) have been greatly restricted due to its low solubility and poor systemic bioavailability. Three-arm amphiphilic copolymer tr... |
PMC11897554 | core_pubmed_pmc | Pharmacokinetic effect of disease severity and use of extracorporeal membrane oxygenation in critically ill Asian patients receiving vancomycin | Pharmacokinetic effect of disease severity and use of extracorporeal membrane oxygenation in critically ill Asian patients receiving vancomycin Abstract Abstract Purpose Vancomycin is an essential antibiotic for the treatment of severe gram-positive bacterial infections, including methicillin-resistant Staphylococcus a... |
PMC12884172 | core_pubmed_pmc | Ginseng and its active compounds in ovarian aging: mechanistic basis and translational prospects | Ginseng and its active compounds in ovarian aging: mechanistic basis and translational prospects Abstract Ovarian aging is characterized by follicular depletion and declining oocyte quality, encompassing both physiological age-related decline and pathological forms such as diminished ovarian reserve, premature ovarian ... |
PMC10399172 | core_pubmed_pmc | Application of Allometric Scaling to Nanochelator Pharmacokinetics | Application of Allometric Scaling to Nanochelator Pharmacokinetics Abstract Deferoxamine (DFO) is an effective FDA-approved iron chelator; however, its use is considerably limited by off-target toxicities and an extremely cumbersome dose regimen involving daily infusions. The recent development of a deferoxamine-based ... |
PMC4224077 | core_pubmed_pmc | Computational investigation of potential dosing schedules for a switch of medication from warfarin to rivaroxaban—an oral, direct Factor Xa inhibitor | Computational investigation of potential dosing schedules for a switch of medication from warfarin to rivaroxaban—an oral, direct Factor Xa inhibitor Abstract Abstract The long-lasting anticoagulant effect of vitamin K antagonists can be problematic in cases of adverse drug reactions or when patients are switched to an... |
PMC10469630 | core_pubmed_pmc | Microfluidic technology and simulation models in studying pharmacokinetics during pregnancy | Microfluidic technology and simulation models in studying pharmacokinetics during pregnancy Abstract Abstract Introduction: Preterm birth rates and maternal and neonatal mortality remain concerning global health issues, necessitating improved strategies for testing therapeutic compounds during pregnancy. Current 2D or ... |
PMC5324257 | core_pubmed_pmc | Malaria parasite clearance | Malaria parasite clearance Abstract Following anti-malarial drug treatment asexual malaria parasite killing and clearance appear to be first order processes. Damaged malaria parasites in circulating erythrocytes are removed from the circulation mainly by the spleen. Splenic clearance functions increase markedly in acut... |
PMC11597675 | core_pubmed_pmc | Principles and Biomedical Applications of Self-Assembled Peptides: Potential Treatment of Type 2 Diabetes Mellitus | Principles and Biomedical Applications of Self-Assembled Peptides: Potential Treatment of Type 2 Diabetes Mellitus Abstract Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder worldwide. There have been tremendous efforts to find a safe and prolonged effective therapy for its treatment. Peptide hor... |
PMC6519757 | core_pubmed_pmc | First‐in‐Human Phase I Study of MBC‐11, a Novel Bone‐Targeted Cytarabine‐Etidronate Conjugate in Patients with Cancer‐Induced Bone Disease | First‐in‐Human Phase I Study of MBC‐11, a Novel Bone‐Targeted Cytarabine‐Etidronate Conjugate in Patients with Cancer‐Induced Bone Disease Abstract Abstract Lessons Learned. Results are consistent with MBC‐11 targeting and treating cancer‐induced bone lesions by concentrating cytarabine and etidronate at the site of di... |
PMC6875711 | core_pubmed_pmc | Physiologically‐Based Pharmacokinetic Modeling vs. Allometric Scaling for the Prediction of Infliximab Pharmacokinetics in Pediatric Patients | Physiologically‐Based Pharmacokinetic Modeling vs. Allometric Scaling for the Prediction of Infliximab Pharmacokinetics in Pediatric Patients Abstract The comparative performances of physiologically‐based pharmacokinetic ( PBPK ) modeling and allometric scaling for predicting the pharmacokinetics (PKs) of large molecul... |
PMC10234547 | core_pubmed_pmc | Population pharmacokinetic model of ivermectin in mass drug administration against lymphatic filariasis | Population pharmacokinetic model of ivermectin in mass drug administration against lymphatic filariasis Abstract Background Ivermectin (IVM) is a broad–spectrum anthelmintic drug used to treat diseases caused by filarial worms, such as onchocerciasis and lymphatic filariasis (LF). IVM is part of a triple–drug therapy u... |
PMC7442995 | core_pubmed_pmc | Pharmacokinetics of Bismuth following Oral Administration of Wei Bi Mei in Healthy Chinese Volunteers | Pharmacokinetics of Bismuth following Oral Administration of Wei Bi Mei in Healthy Chinese Volunteers Abstract Abstract Background Bismuth-containing quadruple therapy achieves higher eradication rate of Helicobacter pylori . High level of bismuth in blood may result in damage of many organs. Wei Bi Mei is a new bismut... |
PMC10812532 | core_pubmed_pmc | Dosage Optimisation of Trimethoprim and Sulfamethoxazole for the Treatment of an Avian Pathogenic Strain of Escherichia coli in Broiler Chickens | Dosage Optimisation of Trimethoprim and Sulfamethoxazole for the Treatment of an Avian Pathogenic Strain of Escherichia coli in Broiler Chickens Abstract Based on pharmacokinetic studies carried out according to the methodologies defined by the European Medicines Agency (EMA) using mass spectrometry analysis, a new for... |
PMC6441814 | core_pubmed_pmc | Pharmacokinetic and pharmacodynamic integration of enrofloxacin against Salmonella Enteritidis after administering to broiler chicken by per-oral and intravenous routes | Pharmacokinetic and pharmacodynamic integration of enrofloxacin against Salmonella Enteritidis after administering to broiler chicken by per-oral and intravenous routes Abstract Abstract It is crucial to optimize the dose of fluoroquinolones to avoid antibiotic resistance and to attain clinical success. We undertook th... |
PMC9293227 | core_pubmed_pmc | Assessment of the Effect of Filgotinib on the Pharmacokinetics of Atorvastatin, Pravastatin, and Rosuvastatin in Healthy Adult Participants | Assessment of the Effect of Filgotinib on the Pharmacokinetics of Atorvastatin, Pravastatin, and Rosuvastatin in Healthy Adult Participants Abstract Abstract Filgotinib, an oral Janus kinase‐1 preferential inhibitor, is approved in Europe and Japan for adults with rheumatoid arthritis. Patients with rheumatoid arthriti... |
PMC12174348 | core_pubmed_pmc | Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis | Monoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis Abstract Abstract Anti-NMDA receptor (NMDAR) encephalitis is a devastating disease with severe psychiatric and neurological symptoms believed to be caused by pathogenic autoantibodies that bind to the N-terminal domain (NTD) o... |
PMC10534867 | core_pubmed_pmc | Topical Micro-Emulsion of 5-Fluorouracil by a Twin Screw Processor-Based Novel Continuous Manufacturing Process for the Treatment of Skin Cancer: Preparation and In Vitro and In Vivo Evaluations | Topical Micro-Emulsion of 5-Fluorouracil by a Twin Screw Processor-Based Novel Continuous Manufacturing Process for the Treatment of Skin Cancer: Preparation and In Vitro and In Vivo Evaluations Abstract 5-Fluorouracil (5-FU), a BCS class III drug, has low oral bioavailability and is cytotoxic in nature causing severe ... |
PMC4249529 | core_pubmed_pmc | Effects of Dosage, Comorbidities, and Food on Isoniazid Pharmacokinetics in Peruvian Tuberculosis Patients | Effects of Dosage, Comorbidities, and Food on Isoniazid Pharmacokinetics in Peruvian Tuberculosis Patients Abstract Poor response to tuberculosis (TB) therapy might be attributable to subtherapeutic levels in drug-compliant patients. Pharmacokinetic (PK) parameters can be affected by several factors, such as comorbidit... |
PMC8775906 | core_pubmed_pmc | Dosing Therapeutic Radiopharmaceuticals in Obese Patients | Dosing Therapeutic Radiopharmaceuticals in Obese Patients Abstract Abstract The prevalence of obesity has increased dramatically in the Western population. Obesity is known to influence not only the proportion of adipose tissue but also physiological processes that could alter drug pharmacokinetics. Yet, there are no s... |
PMC8468506 | core_pubmed_pmc | Direct Oral Anticoagulants in Patients with Obesity and Atrial Fibrillation: Position Paper of Italian National Association of Hospital Cardiologists (ANMCO) | Direct Oral Anticoagulants in Patients with Obesity and Atrial Fibrillation: Position Paper of Italian National Association of Hospital Cardiologists (ANMCO) Abstract Abstract The use of the direct oral anticoagulants dabigatran, rivaroxaban, apixaban and edoxaban (DOACs) offers some major advantages over warfarin and ... |
PMC10044408 | core_pubmed_pmc | Update on Therapeutic Drug Monitoring of Beta-Lactam Antibiotics in Critically Ill Patients—A Narrative Review | Update on Therapeutic Drug Monitoring of Beta-Lactam Antibiotics in Critically Ill Patients—A Narrative Review Abstract Beta-lactam antibiotics remain one of the most preferred groups of antibiotics in critical care due to their excellent safety profiles and their activity against a wide spectrum of pathogens. The corn... |
PMC4370505 | core_pubmed_pmc | Stabilization of Resveratrol in Blood Circulation by Conjugation to mPEG and mPEG-PLA Polymers: Investigation of Conjugate Linker and Polymer Composition on Stability, Metabolism, Antioxidant Activity and Pharmacokinetic Profile | Stabilization of Resveratrol in Blood Circulation by Conjugation to mPEG and mPEG-PLA Polymers: Investigation of Conjugate Linker and Polymer Composition on Stability, Metabolism, Antioxidant Activity and Pharmacokinetic Profile Abstract Abstract Resveratrol is naturally occurring phytochemical with diverse biological ... |
PMC6156125 | core_pubmed_pmc | Chemistry and Hypoglycemic Activity of GPR119 Agonist ZB-16 | Chemistry and Hypoglycemic Activity of GPR119 Agonist ZB-16 Abstract This article is to highlight the chemical properties and primary pharmacology of novel GPR119 agonist ZB-16 and its analogs, which were rejected during the screening. Experiments were performed in vitro (specific activity, metabolism and cell toxicity... |
PMC3858995 | core_pubmed_pmc | Interaction of Acupuncture and Electroacupuncture on the Pharmacokinetics of Aspirin and the Effect of Brain Blood Flow in Rats | Interaction of Acupuncture and Electroacupuncture on the Pharmacokinetics of Aspirin and the Effect of Brain Blood Flow in Rats Abstract Acupuncture and electroacupuncture have been used to improve the brain and motor functions of poststroke patients, and aspirin is used for the prevention of stroke recurrence. Our hyp... |
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