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PMC8698708 | core_pubmed_pmc | Predicting Antimicrobial Activity at the Target Site: Pharmacokinetic/Pharmacodynamic Indices versus Time–Kill Approaches | Predicting Antimicrobial Activity at the Target Site: Pharmacokinetic/Pharmacodynamic Indices versus Time–Kill Approaches Abstract Antibiotic dosing strategies are generally based on systemic drug concentrations. However, drug concentrations at the infection site drive antimicrobial effect, and efficacy predictions and... |
PMC5955430 | core_pubmed_pmc | Using antibody directed phototherapy to target oesophageal adenocarcinoma with heterogeneous HER2 expression | Using antibody directed phototherapy to target oesophageal adenocarcinoma with heterogeneous HER2 expression Abstract Early oesophageal adenocarcinoma (OA) and pre-neoplastic dysplasia may be treated with endoscopic resection and ablative techniques such as photodynamic therapy (PDT). Though effective, discrete areas o... |
PMC12590907 | core_pubmed_pmc | Pharmacokinetics, safety and efficacy of an optimized dose of artemether–lumefantrine in the treatment of acute uncomplicated Plasmodium falciparum malaria in neonates and infants of less than 5 kg body weight: a multicentre, open-label, single-arm phase 2/3 study (CALINA) | Pharmacokinetics, safety and efficacy of an optimized dose of artemether–lumefantrine in the treatment of acute uncomplicated Plasmodium falciparum malaria in neonates and infants of less than 5 kg body weight: a multicentre, open-label, single-arm phase 2/3 study (CALINA) Abstract Background Treatment recommendations ... |
PMC6046171 | core_pubmed_pmc | A Validated LC-MS/MS Method for Simultaneous Determination of Six Aconitum Alkaloids and Seven Ginsenosides in Rat Plasma and Application to Pharmacokinetics of Shen-Fu Prescription | A Validated LC-MS/MS Method for Simultaneous Determination of Six Aconitum Alkaloids and Seven Ginsenosides in Rat Plasma and Application to Pharmacokinetics of Shen-Fu Prescription Abstract Abstract A sensitive and reliable LC-MS/MS method has been developed and validated for simultaneous determination of six Aconitum... |
PMC4875954 | core_pubmed_pmc | Pharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients | Pharmacokinetics of Morphine, Morphine-3-Glucuronide and Morphine-6-Glucuronide in Terminally Ill Adult Patients Abstract Abstract Background and Objective Morphine dosing can be challenging in terminally ill adult patients due to the heterogeneous nature of the population and the difficulty of accurately assessing pai... |
PMC7614325 | core_pubmed_pmc | Cardiovascular concentration–effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies | Cardiovascular concentration–effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies Abstract Aims Amodiaquine is a 4‐aminoquinoline used extensively for the treatment and prevention of malaria. Orally administered amodiaquine is largely converted to the active metab... |
PMC8066800 | core_pubmed_pmc | EV20/NMS-P945, a Novel Thienoindole Based Antibody-Drug Conjugate Targeting HER-3 for Solid Tumors | EV20/NMS-P945, a Novel Thienoindole Based Antibody-Drug Conjugate Targeting HER-3 for Solid Tumors Abstract Abstract HER-3 is becoming an attractive target for antibody–drug conjugate (ADC)-based therapy. Indeed, this receptor and its ligands are found to be overexpressed in several malignancies, and re-activation of i... |
PMC3872531 | core_pubmed_pmc | Pharmacometrics and Systems Pharmacology Software Tutorials and Use: Comments and Guidelines for PSP Contributions | Pharmacometrics and Systems Pharmacology Software Tutorials and Use: Comments and Guidelines for PSP Contributions Abstract In addition to methodological Tutorials, 1 CPT:PSP has recently started to publish software Tutorials. 2 , 3 Our readership and authors may be wondering what kind of format or product is expected,... |
PMC9968262 | core_pubmed_pmc | Pharmacokinetics of Roflumilast Cream in Chronic Plaque Psoriasis: Data from Phase I to Phase III Studies | Pharmacokinetics of Roflumilast Cream in Chronic Plaque Psoriasis: Data from Phase I to Phase III Studies Abstract Abstract Background Most patients with chronic plaque psoriasis receive topical treatment; however, available options lack a balance of efficacy with long-term safety and tolerability. Roflumilast cream 0.... |
PMC6149762 | core_pubmed_pmc | Melatonin Pharmacokinetics Following Oral Administration in Preterm Neonates | Melatonin Pharmacokinetics Following Oral Administration in Preterm Neonates Abstract Abstract Melatonin possesses potential efficacy in perinatal brain injuries, and has been proposed as adjunctive pharmacological therapy in combination with hypothermia in the clinical setting. However, the pharmacokinetics of melaton... |
PMC9952796 | core_pubmed_pmc | Evaluation of Drug Interactions in Hospitalized Patients with Respiratory Disorders in Greece | Evaluation of Drug Interactions in Hospitalized Patients with Respiratory Disorders in Greece Abstract Highlights What are the main findings? Patients admitted for hospitalization in Greece due to respiratory disorders are patients with multimorbidity, polypharmacy, and a high prevalence of drug–drug interactions (DDIs... |
PMC7151081 | core_pubmed_pmc | Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations | Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations Abstract Abstract The treatment of the posterior-segment ocular diseases, such as age-related eye diseases (AMD) or diabetic retinopathy (DR), present a challenge for ophthalmologists due to the complex anatomy and phy... |
PMC8547083 | core_pubmed_pmc | Association of vancomycin trough concentration on the treatment outcome of patients with bacteremia caused by Enterococcus species | Association of vancomycin trough concentration on the treatment outcome of patients with bacteremia caused by Enterococcus species Abstract Abstract Background Pharmacokinetic-pharmacodynamic (PK/PD) targets of vancomycin therapy have been recognized for methicillin-resistant Staphylococcus aureus infections but not fo... |
PMC12669309 | core_pubmed_pmc | Weight-Based Pembrolizumab Dosing at 4 mg/kg Every 6 Weeks Leads to Exposures Below Approved Doses with Unestablished Efficacy: A Pharmacokinetic Model-Based Simulation Analysis | Weight-Based Pembrolizumab Dosing at 4 mg/kg Every 6 Weeks Leads to Exposures Below Approved Doses with Unestablished Efficacy: A Pharmacokinetic Model-Based Simulation Analysis Abstract Abstract Background Pembrolizumab is approved globally at a dose of 200 mg every 3 weeks (Q3W) or 400 mg every 6 weeks (Q6W) intraven... |
PMC7341284 | core_pubmed_pmc | Pharmacokinetic Profile of Oral Administration of Mefloquine to Clinically Normal Cats: A Preliminary In-Vivo Study of a Potential Treatment for Feline Infectious Peritonitis (FIP) | Pharmacokinetic Profile of Oral Administration of Mefloquine to Clinically Normal Cats: A Preliminary In-Vivo Study of a Potential Treatment for Feline Infectious Peritonitis (FIP) Abstract Simple Summary In searching for antiviral agents against feline coronaviruses and feline caliciviruses, mefloquine, a human anti-m... |
PMC5697692 | core_pubmed_pmc | Exposure–Response Analysis of Nivolumab in Patients With Previously Treated or Untreated Advanced Melanoma | Exposure–Response Analysis of Nivolumab in Patients With Previously Treated or Untreated Advanced Melanoma Methods Methods The analysis population consisted of previously treated and untreated patients with advanced melanoma in the following studies who had been treated with nivolumab, and for whom nivolumab serum conc... |
PMC6854236 | core_pubmed_pmc | Opioid Safety and Concomitant Benzodiazepine Use in End-Stage Renal Disease Patients | Opioid Safety and Concomitant Benzodiazepine Use in End-Stage Renal Disease Patients Abstract Abstract Background Opioid use is common in end-stage renal disease (ESRD) patients. However, safety of individual opioids and concomitant benzodiazepine use has not been studied. Objective To study the epidemiology of opioid ... |
PMC5951785 | core_pubmed_pmc | Pharmacokinetics of Hydroxyprogesterone Caproate and its Primary Metabolites during Pregnancy | Pharmacokinetics of Hydroxyprogesterone Caproate and its Primary Metabolites during Pregnancy Abstract Objective To measure pharmacokinetics of hydroxyprogesterone caproate (OHPC) and its major metabolites throughout pregnancy. Study Design Thirty women were prescribed OHPC for recurrent preterm birth prevention. Three... |
PMC11315861 | core_pubmed_pmc | Understanding Drug Exposure and Trichuris trichiura Cure Rates: A Pharmacometric Approach for Albendazole-Ivermectin Co-medication in Tanzania and Côte d’Ivoire | Understanding Drug Exposure and Trichuris trichiura Cure Rates: A Pharmacometric Approach for Albendazole-Ivermectin Co-medication in Tanzania and Côte d’Ivoire Abstract Abstract Background and Objective Trichuriasis caused by the human whipworm Trichuris trichiura poses a significant public health concern. Albendazole... |
PMC10327396 | core_pubmed_pmc | The impact of ABCB1 , CYP3A4/5 and ABCG2 gene polymorphisms on rivaroxaban trough concentrations and bleeding events in patients with non-valvular atrial fibrillation | The impact of ABCB1 , CYP3A4/5 and ABCG2 gene polymorphisms on rivaroxaban trough concentrations and bleeding events in patients with non-valvular atrial fibrillation Abstract Abstract Background The influence of genetic factors on the pharmacokinetics and clinical outcomes of rivaroxaban in patients with non-valvular ... |
PMC8021898 | core_pubmed_pmc | COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms | COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms Abstract Abstract SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. SARS-CoV-2 infection is necessary but not sufficient for development of clinical COVID-19 disease. Currently, ther... |
PMC6431017 | core_pubmed_pmc | Bayesian network-based framework for exposure-response study design and interpretation | Bayesian network-based framework for exposure-response study design and interpretation Abstract Abstract Conventional environmental-health risk-assessment methods are often limited in their ability to account for uncertainty in contaminant exposure, chemical toxicity and resulting human health risk. Exposure levels and... |
PMC9399922 | core_pubmed_pmc | Pharmacokinetics and bioequivalence of two cyclosporine oral solution formulations in cats | Pharmacokinetics and bioequivalence of two cyclosporine oral solution formulations in cats Abstract Abstract The pharmacokinetic profiles and bioequivalence of two cyclosporine oral solutions were investigated in cats. Twenty-four cats were randomly allocated to two equally sized treatment groups in a randomized four-c... |
PMC10252891 | core_pubmed_pmc | Pharmacometabolic Effects of Pteryxin and Valproate on Pentylenetetrazole-Induced Seizures in Zebrafish Reveal Vagus Nerve Stimulation | Pharmacometabolic Effects of Pteryxin and Valproate on Pentylenetetrazole-Induced Seizures in Zebrafish Reveal Vagus Nerve Stimulation Abstract Abstract Zebrafish (Danio rerio) assays provide a versatile pharmacological platform to test compounds on a wide range of behaviors in a whole organism. A major challenge lies ... |
PMC9114963 | core_pubmed_pmc | Anti-CSF-1R emactuzumab in combination with anti-PD-L1 atezolizumab in advanced solid tumor patients naïve or experienced for immune checkpoint blockade | Anti-CSF-1R emactuzumab in combination with anti-PD-L1 atezolizumab in advanced solid tumor patients naïve or experienced for immune checkpoint blockade Abstract Background This phase 1b study ( NCT02323191 ) evaluated the safety, antitumor activity, pharmacokinetics, and pharmacodynamics of colony-stimulating factor-1... |
PMC11868035 | core_pubmed_pmc | Evaluation of the Landscape of Pharmacodynamic Biomarkers in GM1 and GM2 Gangliosidosis | Evaluation of the Landscape of Pharmacodynamic Biomarkers in GM1 and GM2 Gangliosidosis Abstract ABSTRACT GM1 and GM2 gangliosidosis are inherited, progressive, neurodegenerative lysosomal disorders of variable onset and disease progression. GM1 gangliosidosis is a result of biallelic pathogenic variants in the GLB1 ge... |
PMC10516122 | core_pubmed_pmc | Site-Specific Antibody Conjugation Using Modified Bisected N -Glycans: Method Development and Potential toward Tunable Effector Function | Site-Specific Antibody Conjugation Using Modified Bisected N -Glycans: Method Development and Potential toward Tunable Effector Function Abstract Abstract Antibody–drug conjugates (ADCs) have garnered worldwide attention for disease treatment, as they possess high target specificity, a long half-life, and outstanding p... |
PMC9169852 | core_pubmed_pmc | Cefquinome Sulfate Oily Nanosuspension Designed for Improving its Bioavailability in the Treatment of Veterinary Infections | Cefquinome Sulfate Oily Nanosuspension Designed for Improving its Bioavailability in the Treatment of Veterinary Infections Abstract Introduction Cefquinome sulfate (CS) is the first fourth-generation antibiotic for animals, which has a wide antibacterial spectrum, strong antibacterial activity and low drug resistance.... |
PMC11621409 | core_pubmed_pmc | Analysis of queries to a Swedish drug information centre identifies scientific knowledge gaps | Analysis of queries to a Swedish drug information centre identifies scientific knowledge gaps Abstract Drug Information Centres (DICs) are providing clinicians with evidence-based support for rational drug treatment. However, knowledge gaps in the literature may hinder DICs from offering optimal guidance. This study ex... |
PMC12425547 | core_pubmed_pmc | Network pharmacology, molecular docking, and molecular dynamics analyses to explore the molecular mechanism of paclitaxel in atherosclerosis therapy | Network pharmacology, molecular docking, and molecular dynamics analyses to explore the molecular mechanism of paclitaxel in atherosclerosis therapy Abstract Abstract Atherosclerosis is a chronic arterial disease and the leading cause of vascular death. Paclitaxel has long been recognized as an anticancer agent, but re... |
PMC12108460 | core_pubmed_pmc | High-Dose Ceftriaxone in Elderly Patients with Enterococcal Infective Endocarditis: Population Pharmacokinetics of Free Ceftriaxone and Dose Optimization | High-Dose Ceftriaxone in Elderly Patients with Enterococcal Infective Endocarditis: Population Pharmacokinetics of Free Ceftriaxone and Dose Optimization Abstract Abstract Background: Ampicillin plus ceftriaxone (AC) is a first-line treatment for Enterococcus faecalis infective endocarditis (IE). Its administration in ... |
PMC7318010 | core_pubmed_pmc | Pooled Multicenter Analysis of Cardiovascular Safety and Population Pharmacokinetic Properties of Piperaquine in African Patients with Uncomplicated Falciparum Malaria | Pooled Multicenter Analysis of Cardiovascular Safety and Population Pharmacokinetic Properties of Piperaquine in African Patients with Uncomplicated Falciparum Malaria Abstract Dihydroartemisinin-piperaquine has shown excellent efficacy and tolerability in malaria treatment. However, concerns have been raised of potent... |
PMC9026026 | core_pubmed_pmc | Effect of Myricetin on CYP2C8 Inhibition to Assess the Likelihood of Drug Interaction Using In Silico , In Vitro , and In Vivo Approaches | Effect of Myricetin on CYP2C8 Inhibition to Assess the Likelihood of Drug Interaction Using In Silico , In Vitro , and In Vivo Approaches Abstract Abstract Myricetin, a bioflavonoid, is widely used as functional food/complementary medicine and has promising multifaceted pharmacological actions against therapeutically v... |
PMC9299784 | core_pubmed_pmc | Proteomics of colorectal cancer liver metastasis: A quantitative focus on drug elimination and pharmacodynamics effects | Proteomics of colorectal cancer liver metastasis: A quantitative focus on drug elimination and pharmacodynamics effects Abstract Abstract Aims This study aims to quantify drug‐metabolising enzymes, transporters, receptor tyrosine kinases (RTKs) and protein markers (involved in pathways affected in cancer) in pooled hea... |
PMC4674584 | core_pubmed_pmc | Evaluation of Waste Anesthetic Gas in the Postanesthesia Care Unit within the Patient Breathing Zone | Evaluation of Waste Anesthetic Gas in the Postanesthesia Care Unit within the Patient Breathing Zone Abstract Potential health hazards from waste anesthetic gases (WAGs) have been a concern since the introduction of inhalational anesthetics into clinical practice. The potential to exceed recommended exposure levels (RE... |
PMC11814085 | core_pubmed_pmc | Application of drug-induced growth rate inhibition and intracellular drug exposures for comprehensive evaluation of cellular drug sensitivity | Application of drug-induced growth rate inhibition and intracellular drug exposures for comprehensive evaluation of cellular drug sensitivity Abstract In vitro cellular assays are indispensable tools for preclinical understanding of therapeutic candidates. Herein, we have outlined methods for robust determination of ce... |
PMC3934716 | core_pubmed_pmc | Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats | Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats Abstract Abstract A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (D... |
PMC3328159 | core_pubmed_pmc | Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication | Pharmacokinetics of Hyperthermic Intrathoracic Chemotherapy following Pleurectomy and Decortication Abstract Abstract In patients with pseudomyxoma peritonei or peritoneal mesothelioma, direct extension of disease through the hemidiaphragm may result in an isolated progression of tumor within the pleural space. We moni... |
PMC9465641 | core_pubmed_pmc | Population pharmacokinetics of intravenous colistin sulfate and dosage optimization in critically ill patients | Population pharmacokinetics of intravenous colistin sulfate and dosage optimization in critically ill patients Abstract Aims: To explore the population pharmacokinetics of colistin sulfate and to optimize the dosing strategy for critically ill patients. Methods: The study enrolled critically ill adult patients who rece... |
PMC7958305 | core_pubmed_pmc | Ligelizumab treatment for severe asthma: learnings from the clinical development programme | Ligelizumab treatment for severe asthma: learnings from the clinical development programme Abstract Abstract Objective Ligelizumab is a humanised IgG1 anti‐IgE antibody that binds IgE with higher affinity than omalizumab. Ligelizumab had greater efficacy than omalizumab on inhaled and skin allergen provocation response... |
PMC7303059 | core_pubmed_pmc | Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice | Comparison of the toxicokinetics of the convulsants picrotoxinin and tetramethylenedisulfotetramine (TETS) in mice Abstract Acute intoxication with picrotoxin or the rodenticide tetramethylenedisulfotetramine (TETS) can cause seizures that rapidly progress to status epilepticus and death. Both compounds inhibit γ-amino... |
PMC10196151 | core_pubmed_pmc | Pharmacokinetic studies of hyperoside -2-hydroxypropyl-β-cyclodextrin inclusion complex and ameliorated DSS-induced colitis in mice | Pharmacokinetic studies of hyperoside -2-hydroxypropyl-β-cyclodextrin inclusion complex and ameliorated DSS-induced colitis in mice Abstract Abstract An inclusion complex formation with cyclodextrin is a promising method to improve the bioavailability of water-insoluble drugs. The pharmacokinetic characteristics of Hyp... |
PMC12193971 | core_pubmed_pmc | Optimization of Isavuconazole Dosing in Patients with Invasive Fungal Infections Through Therapeutic Drug Monitoring: Real-World Clinical Practice Experience | Optimization of Isavuconazole Dosing in Patients with Invasive Fungal Infections Through Therapeutic Drug Monitoring: Real-World Clinical Practice Experience Abstract Abstract Therapeutic drug monitoring (TDM) is routinely recommended for most antifungal triazoles to ensure efficacy and safety. Isavuconazole, however, ... |
PMC4128846 | core_pubmed_pmc | Potential patient benefit of a subcutaneous formulation of tocilizumab for the treatment of rheumatoid arthritis: a critical review | Potential patient benefit of a subcutaneous formulation of tocilizumab for the treatment of rheumatoid arthritis: a critical review Abstract Abstract Treatment of rheumatoid arthritis (RA) was revolutionized during the last decade with the development of new biologic disease-modifying anti-rheumatic drugs (DMARDs) enab... |
PMC9796261 | core_pubmed_pmc | Pharmacokinetic Characteristics, Safety, and Tolerability of Telitacicept, an Injectable Recombinant Human B‐Lymphocyte Stimulating Factor Receptor‐Antibody Fusion Protein, in Healthy Chinese Subjects | Pharmacokinetic Characteristics, Safety, and Tolerability of Telitacicept, an Injectable Recombinant Human B‐Lymphocyte Stimulating Factor Receptor‐Antibody Fusion Protein, in Healthy Chinese Subjects Abstract Abstract Telitacicept, an injectable recombinant human B‐lymphocyte stimulating factor receptor‐antibody fusio... |
PMC9727334 | core_pubmed_pmc | Molecular Docking and in silico Pharmacological Screening of Oleosin from Cocos Nucifera Complexed with Tamoxifen in Developing Potential Breast Chemotherapeutic Leads | Molecular Docking and in silico Pharmacological Screening of Oleosin from Cocos Nucifera Complexed with Tamoxifen in Developing Potential Breast Chemotherapeutic Leads Abstract Objective: Tamoxifen is a widely used drug for breast cancer therapy; however, concerns and controversies regarding its efficiency arise as it ... |
PMC3677634 | core_pubmed_pmc | Improved HPLC Method for the Determination of Moxifloxacin in Application to a Pharmacokinetics Study in Patients with Infectious Diseases | Improved HPLC Method for the Determination of Moxifloxacin in Application to a Pharmacokinetics Study in Patients with Infectious Diseases Abstract Objective . To develop a simple and rapid high-performance liquid chromatography (HPLC) method for measuring moxifloxacin concentration in human plasma. Methods . Following... |
PMC10019422 | core_pubmed_pmc | Clinical Pharmacokinetics and Pharmacodynamics of CSL112 | Clinical Pharmacokinetics and Pharmacodynamics of CSL112 Abstract Cardiovascular diseases are the leading cause of death worldwide. Although there have been substantial advances over the last decades, recurrent adverse cardiovascular events after myocardial infarction are still frequent, particularly during the first y... |
PMC10497461 | core_pubmed_pmc | Acute-on-chronic liver failure alters linezolid pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study | Acute-on-chronic liver failure alters linezolid pharmacokinetics in critically ill patients with continuous hemodialysis: an observational study Abstract Abstract Background In acute-on-chronic liver failure (ACLF), adequate antibiotic dosing is challenging due to changes of drug distribution and elimination. We studie... |
PMC11137731 | core_pubmed_pmc | AlbuCatcher for Long-Acting Therapeutics | AlbuCatcher for Long-Acting Therapeutics Abstract Therapeutic proteins, pivotal for treating diverse human diseases due to their biocompatibility and high selectivity, often face challenges such as rapid serum clearance, enzymatic degradation, and immune responses. To address these issues and enable prolonged therapeut... |
PMC5093207 | core_pubmed_pmc | Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging | Pre-clinical Evaluation of a Cyanine-Based SPECT Probe for Multimodal Tumor Necrosis Imaging Abstract Abstract Purpose Recently we showed that a number of carboxylated near-infrared fluorescent (NIRF) cyanine dyes possess strong necrosis avid properties in vitro as well as in different mouse models of spontaneous and t... |
PMC9039133 | core_pubmed_pmc | Cefiderocol for the Treatment of Multidrug-Resistant Gram-Negative Bacteria: A Systematic Review of Currently Available Evidence | Cefiderocol for the Treatment of Multidrug-Resistant Gram-Negative Bacteria: A Systematic Review of Currently Available Evidence Abstract Cefiderocol is a novel synthetic siderophore-conjugated antibiotic that hijacks the bacterial iron transport systems facilitating drug entry into cells, achieving high periplasmic co... |
PMC11382518 | core_pubmed_pmc | Uncover the anticancer potential of lycorine | Uncover the anticancer potential of lycorine Abstract Background Natural products have a long history in drug discovery. Lycorine is an alkaloid derived from Amaryllidaceae plants, demonstrating significant pharmacological potential. Lycorine and its hydrochloride salt, lycorine hydrochloride, have shown outstanding an... |
PMC5347705 | core_pubmed_pmc | Combinatorial effects of doxorubicin and retargeted tissue factor by intratumoral entrapment of doxorubicin and proapoptotic increase of tumor vascular infarction | Combinatorial effects of doxorubicin and retargeted tissue factor by intratumoral entrapment of doxorubicin and proapoptotic increase of tumor vascular infarction Abstract Abstract Truncated tissue factor (tTF), retargeted to tumor vasculature by GNGRAHA peptide (tTF-NGR), and doxorubicin have therapeutic activity agai... |
PMC6078047 | core_pubmed_pmc | In vitro and in vivo Assessment of Keratose as a Novel Excipient of Paclitaxel Coated Balloons | In vitro and in vivo Assessment of Keratose as a Novel Excipient of Paclitaxel Coated Balloons Abstract Purpose: Drug coated balloons (DCB) are continually improving due to advances in coating techniques and more effective excipients. Paclitaxel, the current drug choice of DCB, is a microtubule-stabilizing chemotherape... |
PMC3419960 | core_pubmed_pmc | Phase I study investigating the safety and feasibility of combining imatinib mesylate (Gleevec) with sorafenib in patients with refractory castration-resistant prostate cancer | Phase I study investigating the safety and feasibility of combining imatinib mesylate (Gleevec) with sorafenib in patients with refractory castration-resistant prostate cancer Abstract Abstract Background: Determining the maximum tolerated dose (MTD) and the dose-limiting toxicity (DLT) of sorafenib (S) plus imatinib (... |
PMC7238799 | core_pubmed_pmc | Safety, tolerability, and pharmacokinetics of the selective prostacyclin receptor agonist ralinepag in single and multiple dosing studies of an immediate-release oral formulation in healthy volunteers | Safety, tolerability, and pharmacokinetics of the selective prostacyclin receptor agonist ralinepag in single and multiple dosing studies of an immediate-release oral formulation in healthy volunteers Abstract Ralinepag (APD811), an oral, potent, and selective prostacyclin receptor (IP) agonist is being developed for t... |
PMC12089282 | core_pubmed_pmc | Safety and cognitive pharmacodynamics following dose escalations with 3-methylmethcathinone (3-MMC): a first in human, designer drug study | Safety and cognitive pharmacodynamics following dose escalations with 3-methylmethcathinone (3-MMC): a first in human, designer drug study Abstract Abstract 3-Methylmethcathinone (3-MMC) is a designer drug that belongs to the group of synthetic cathinones. The compound has been scheduled in many jurisdictions because o... |
PMC8018653 | core_pubmed_pmc | Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights | Gender-based differences in brain and plasma pharmacokinetics of letrozole in sprague-dawley rats: Application of physiologically-based pharmacokinetic modeling to gain quantitative insights Abstract Based on the discovery that the estrogen synthase aromatase (CYP19A1) is abundantly expressed in high- grade gliomas, th... |
PMC8283337 | core_pubmed_pmc | Neural-ODE for pharmacokinetics modeling and its advantage to alternative machine learning models in predicting new dosing regimens | Neural-ODE for pharmacokinetics modeling and its advantage to alternative machine learning models in predicting new dosing regimens Abstract Summary Forecasting pharmacokinetics (PK) for individual patients is a fundamental problem in clinical pharmacology. One key challenge is that PK models constructed using data fro... |
PMC8376138 | core_pubmed_pmc | PK/PD modeling of FXI antisense oligonucleotides to bridge the dose‐FXI activity relation from healthy volunteers to end‐stage renal disease patients | PK/PD modeling of FXI antisense oligonucleotides to bridge the dose‐FXI activity relation from healthy volunteers to end‐stage renal disease patients Abstract Abstract IONIS‐FXI RX (BAY2306001) is an antisense oligonucleotide that inhibits the synthesis of coagulation factor XI (FXI) and has been investigated in health... |
PMC3553515 | core_pubmed_pmc | Phase I and pharmacodynamic study of high-dose NGR–hTNF in patients with refractory solid tumours | Phase I and pharmacodynamic study of high-dose NGR–hTNF in patients with refractory solid tumours Abstract Abstract Background: NGR–hTNF exploits the peptide asparagine–glycine–arginine (NGR) for selectively targeting tumour necrosis factor (TNF) to CD13-overexpressing tumour vessels. Maximum-tolerated dose (MTD) of NG... |
PMC12905974 | core_pubmed_pmc | Discontinuation of the development of remimazolam for ICU sedation in Japan: background and rationale | Discontinuation of the development of remimazolam for ICU sedation in Japan: background and rationale Abstract Abstract Remimazolam, an ultra-short-acting benzodiazepine rapidly metabolized by carboxylesterase-1, was developed as a promising alternative for ICU sedation. It was anticipated to overcome the unpredictable... |
PMC11578139 | core_pubmed_pmc | Population PK modeling of certolizumab pegol in pregnant women with chronic inflammatory diseases | Population PK modeling of certolizumab pegol in pregnant women with chronic inflammatory diseases Abstract Abstract Certolizumab pegol (CZP; CIMZIA™) is the only Fc‐free tumor necrosis factor inhibitor with data from a clinical study demonstrating no to minimal placental transfer. The pharmacokinetics (PK) of certolizu... |
PMC12891982 | core_pubmed_pmc | Gentamicin fails to eradicate Staphylococcus aureus biofilm in vitro, even in combination with rifampin | Gentamicin fails to eradicate Staphylococcus aureus biofilm in vitro, even in combination with rifampin Abstract Abstract Introduction : Biofilm formation is one of the key elements making orthopaedic device-related infections (ODRIs) difficult to eradicate. Aminoglycosides such as gentamicin are frequently applied via... |
PMC12146541 | core_pubmed_pmc | Evaluation of pharmacokinetics of intravenous protein C concentrate in protein C deficiency: implications for treatment initiation and maintenance | Evaluation of pharmacokinetics of intravenous protein C concentrate in protein C deficiency: implications for treatment initiation and maintenance Abstract Abstract Background Dosing of intravenous protein C concentrate (Ceprotin) in patients with protein C deficiency is guided by pharmacokinetics (PK) of plasma protei... |
PMC9317565 | core_pubmed_pmc | Tumor-Localized Administration of α-GalCer to Recruit Invariant Natural Killer T Cells and Enhance Their Antitumor Activity against Solid Tumors | Tumor-Localized Administration of α-GalCer to Recruit Invariant Natural Killer T Cells and Enhance Their Antitumor Activity against Solid Tumors Abstract Abstract Invariant natural killer T (iNKT) cells have the capacity to mount potent anti-tumor reactivity and have therefore become a focus in the development of cell-... |
PMC5322938 | core_pubmed_pmc | Biosimilars and the extrapolation of indications for inflammatory conditions | Biosimilars and the extrapolation of indications for inflammatory conditions Abstract Extrapolation is the approval of a biosimilar for use in an indication held by the originator biologic not directly studied in a comparative clinical trial with the biosimilar. Extrapolation is a scientific rationale that bridges all ... |
PMC10604776 | core_pubmed_pmc | Real-Time TDM-Based Expert Clinical Pharmacological Advice Program for Attaining Aggressive Pharmacokinetic/Pharmacodynamic Target of Continuous Infusion Meropenem in the Treatment of Critically Ill Patients with Documented Gram-Negative Infections Undergoing Continuous Veno-Venous Hemodiafiltration | Real-Time TDM-Based Expert Clinical Pharmacological Advice Program for Attaining Aggressive Pharmacokinetic/Pharmacodynamic Target of Continuous Infusion Meropenem in the Treatment of Critically Ill Patients with Documented Gram-Negative Infections Undergoing Continuous Veno-Venous Hemodiafiltration Abstract Abstract (... |
PMC12038368 | core_pubmed_pmc | Impacts of Pharmacokinetic Gene Polymorphisms on Steady‐State Plasma Concentrations of Simvastatin in Thai Population | Impacts of Pharmacokinetic Gene Polymorphisms on Steady‐State Plasma Concentrations of Simvastatin in Thai Population Abstract ABSTRACT Simvastatin, an HMG‐CoA reductase inhibitor, is widely used for hypercholesterolemia but may cause myotoxicity linked to its plasma concentration. Pharmacokinetic gene polymorphisms in... |
PMC8301550 | core_pubmed_pmc | Evolving drug regulatory landscape in China: A clinical pharmacology perspective | Evolving drug regulatory landscape in China: A clinical pharmacology perspective Abstract Abstract In order to encourage innovative medicine to address Chinese unmet medical needs, China has changed its drug regulatory landscape to speed up access to new medicines. In order to understand the fast‐changing landscape and... |
PMC11041816 | core_pubmed_pmc | Comparison of Fat-Free Mass and Ideal Body Weight Scalar for Anesthetic Induction Dose of Propofol in Patients with Morbid Obesity: A Double-Blind, Randomized Clinical Trial | Comparison of Fat-Free Mass and Ideal Body Weight Scalar for Anesthetic Induction Dose of Propofol in Patients with Morbid Obesity: A Double-Blind, Randomized Clinical Trial Abstract Background Obesity is a growing problem worldwide and can affect both the pharmacodynamics and pharmacokinetics of various drugs, includi... |
PMC6468928 | core_pubmed_pmc | Population pharmacokinetics of tacrolimus in pediatric refractory nephrotic syndrome and a summary of other pediatric disease models | Population pharmacokinetics of tacrolimus in pediatric refractory nephrotic syndrome and a summary of other pediatric disease models Abstract Abstract Different tacrolimus (TAC) population pharmacokinetic (PPK) models have been established in various pediatric disease populations. However, a TAC PPK model for pediatric... |
PMC10303079 | core_pubmed_pmc | Bioinformatics Tools for the Analysis of Active Compounds Identified in Ranunculaceae Species | Bioinformatics Tools for the Analysis of Active Compounds Identified in Ranunculaceae Species Abstract Abstract The chemical compounds from extracts of three Ranunculaceae species, Aconitum toxicum Rchb., Anemone nemorosa L. and Helleborus odorus Waldst. & Kit. ex Willd., respectively, were isolated using the HPLC puri... |
PMC9960997 | core_pubmed_pmc | Targeted Therapy of Severe Infections Caused by Staphylococcus aureus in Critically Ill Adult Patients: A Multidisciplinary Proposal of Therapeutic Algorithms Based on Real-World Evidence | Targeted Therapy of Severe Infections Caused by Staphylococcus aureus in Critically Ill Adult Patients: A Multidisciplinary Proposal of Therapeutic Algorithms Based on Real-World Evidence Abstract (1) Introduction: To develop evidence-based algorithms for targeted antibiotic therapy of infections caused by Staphylococc... |
PMC4949308 | core_pubmed_pmc | Transgender women, hormonal therapy and HIV treatment: a comprehensive review of the literature and recommendations for best practices | Transgender women, hormonal therapy and HIV treatment: a comprehensive review of the literature and recommendations for best practices Abstract Abstract Introduction Studies have shown that transgender women (TGW) are disproportionately affected by HIV, with an estimated HIV prevalence of 19.1% among TGW worldwide. Aft... |
PMC8390684 | core_pubmed_pmc | Optimal loading dose of meropenem before continuous infusion in critically ill patients: a simulation study | Optimal loading dose of meropenem before continuous infusion in critically ill patients: a simulation study Abstract The aim of this study was to investigate optimal loading doses prior to continuous infusion of meropenem in critically ill patients. A previously published and successfully evaluated pharmacokinetic mode... |
PMC7828633 | core_pubmed_pmc | Impact of CNS Diseases on Drug Delivery to Brain Extracellular and Intracellular Target Sites in Human: A “WHAT-IF” Simulation Study | Impact of CNS Diseases on Drug Delivery to Brain Extracellular and Intracellular Target Sites in Human: A “WHAT-IF” Simulation Study Abstract Abstract The blood–brain barrier (BBB) is equipped with unique physical and functional processes that control central nervous system (CNS) drug transport and the resulting concen... |
PMC5715639 | core_pubmed_pmc | Effects of mistletoe products on pharmacokinetic drug turnover by inhibition and induction of cytochrome P450 activities | Effects of mistletoe products on pharmacokinetic drug turnover by inhibition and induction of cytochrome P450 activities Abstract Abstract Background European mistletoe ( Viscum album ) products used in cancer therapy are frequently combined with other anti-cancer-drugs. Hence, potential herb-drug interactions have bec... |
PMC3978888 | core_pubmed_pmc | Safety, tolerability, pharmacokinetics and pharmacodynamics of an anti- oncostatin M monoclonal antibody in rheumatoid arthritis: results from phase II randomized, placebo-controlled trials | Safety, tolerability, pharmacokinetics and pharmacodynamics of an anti- oncostatin M monoclonal antibody in rheumatoid arthritis: results from phase II randomized, placebo-controlled trials Abstract Introduction Oncostatin M (OSM) has been implicated in the pathophysiology of rheumatoid arthritis (RA) through its effec... |
PMC5423235 | core_pubmed_pmc | Antibacterial Loaded Spray Dried Chitosan Polyelectrolyte Complexes as Dry Powder Aerosol for the Treatment of Lung Infections | Antibacterial Loaded Spray Dried Chitosan Polyelectrolyte Complexes as Dry Powder Aerosol for the Treatment of Lung Infections Abstract Inhalation delivery of aerosolized antibacterials is preferred over conventional methods of delivery for targeting lung infection. The present study is concerned with the development a... |
PMC10669052 | core_pubmed_pmc | Exploring Differences in Pharmacometrics of Rabeprazole between Genders via Population Pharmacokinetic–Pharmacodynamic Modeling | Exploring Differences in Pharmacometrics of Rabeprazole between Genders via Population Pharmacokinetic–Pharmacodynamic Modeling Abstract Rabeprazole is a proton pump inhibitor that inhibits gastric acid production and increases gastric pH; it is widely used clinically as a treatment option for gastritis and gastric ulc... |
PMC5966501 | core_pubmed_pmc | Evidence-Based Recommendations to Improve the Safe Use of Drugs in Patients with Liver Cirrhosis | Evidence-Based Recommendations to Improve the Safe Use of Drugs in Patients with Liver Cirrhosis Abstract Introduction The presence of liver cirrhosis can have a major impact on pharmacodynamics and pharmacokinetics, but guidance for prescribing is lacking. Objective The aim of this study is to provide an overview of e... |
PMC6182730 | core_pubmed_pmc | Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale | Extrapolation of praziquantel pharmacokinetics to a pediatric population: a cautionary tale Abstract L-praziquantel (PZQ) pharmacokinetic data were analyzed from two relative bioavailability Phase 1 studies in adult, healthy subjects with two new oral dispersion tablet (ODT) formulations of L-PZQ administered under var... |
PMC11148501 | core_pubmed_pmc | CYP2D6 isoenzyme and ABCB1 gene polymorphisms associated with postoperative nausea and vomiting in women undergoing laparoscopic cholecystectomy: a randomized trial | CYP2D6 isoenzyme and ABCB1 gene polymorphisms associated with postoperative nausea and vomiting in women undergoing laparoscopic cholecystectomy: a randomized trial Abstract Introduction Postoperative nausea and vomiting is still a common complication. Serotonin receptor antagonists are commonly used in clinical practi... |
PMC12945708 | core_pubmed_pmc | Population Pharmacokinetics and Exposure‐Response Analyses for Telisotuzumab Vedotin in Patients With c‐Met Protein Overexpressing Tumors | Population Pharmacokinetics and Exposure‐Response Analyses for Telisotuzumab Vedotin in Patients With c‐Met Protein Overexpressing Tumors Abstract ABSTRACT Telisotuzumab vedotin (Teliso‐V) is a c‐Met‐directed antibody‐drug conjugate that delivers a cytotoxic microtubule inhibitor monomethyl auristatin E (MMAE) payload ... |
PMC8147951 | core_pubmed_pmc | Emergent Drug and Nutrition Interactions in COVID-19: A Comprehensive Narrative Review | Emergent Drug and Nutrition Interactions in COVID-19: A Comprehensive Narrative Review Abstract Coronaviruses are a large family of viruses that are known to cause respiratory tract infections ranging from colds to more severe diseases, such as Middle East Respiratory Syndrome (MERS) and the Severe Acute Respiratory Sy... |
PMC5656880 | core_pubmed_pmc | Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology | Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology Abstract Abstract Despite the fact that pharmacokinetic exposure of kinase inhibitors (KIs) is highly variable and clear relationships exist between exposure and treatment outcomes, fixed dosing is still standard practice. This r... |
PMC10175687 | core_pubmed_pmc | Population pharmacokinetic analysis and dosing regimen optimization of teicoplanin in critically ill patients with sepsis | Population pharmacokinetic analysis and dosing regimen optimization of teicoplanin in critically ill patients with sepsis Abstract Abstract Objectives: Teicoplanin has been extensively used in the treatment for infections caused by gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). How... |
PMC4671243 | core_pubmed_pmc | Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK) | Associations of Perfluoroalkyl Substances (PFAS) with Lower Birth Weight: An Evaluation of Potential Confounding by Glomerular Filtration Rate Using a Physiologically Based Pharmacokinetic Model (PBPK) Abstract Abstract Background Prenatal exposure to perfluoroalkyl substances (PFAS) has been associated with lower birt... |
PMC5498502 | core_pubmed_pmc | Bioavailability and pharmacokinetic comparison of tanshinones between two formulations of Salvia miltiorrhiza in healthy volunteers | Bioavailability and pharmacokinetic comparison of tanshinones between two formulations of Salvia miltiorrhiza in healthy volunteers Abstract Salvia miltiorrhiza (SM) is widely used to treat microcirculatory disturbance-related diseases; its lipophilic components play important roles in this application. Cryptotanshinon... |
PMC5431879 | core_pubmed_pmc | Pharmacometabolomics for predicting variable busulfan exposure in paediatric haematopoietic stem cell transplantation patients | Pharmacometabolomics for predicting variable busulfan exposure in paediatric haematopoietic stem cell transplantation patients Abstract Abstract Owing to its narrow therapeutic range and high pharmacokinetic variability, optimal dosing for busulfan is important to minimise overexposure-related systemic toxicity and und... |
PMC3304372 | core_pubmed_pmc | Development and validation of a rapid HPLC- fluorescence method for simultaneous determination of venlafaxine and its major metabolites in human plasma | Development and validation of a rapid HPLC- fluorescence method for simultaneous determination of venlafaxine and its major metabolites in human plasma Abstract Background and the purpose of the study To develop a simple, rapid and accurate HPLC method for the measurement of the venlafaxine and its main metabolites, O ... |
PMC6566363 | core_pubmed_pmc | pH-Sensitive Ratiometric Fluorescent Probe for Evaluation of Tumor Treatments | pH-Sensitive Ratiometric Fluorescent Probe for Evaluation of Tumor Treatments Abstract Determining therapeutic efficacy is critical for tumor precision theranostics. In order to monitor the efficacy of anti-cancer drugs (e.g., Paclitaxel), a pH-sensitive ratiometric fluorescent imaging probe was constructed. The pH-sen... |
PMC7002734 | core_pubmed_pmc | Comparative pharmacokinetics of osmotic-controlled and immediate-release Eperisone tablet formulation in healthy human subjects using a sensitive plasma LC-ESI-MS/MS method | Comparative pharmacokinetics of osmotic-controlled and immediate-release Eperisone tablet formulation in healthy human subjects using a sensitive plasma LC-ESI-MS/MS method Abstract To evaluate and compare the pharmacokinetic (PK) characteristics of a newly developed oral osmotically controlled drug delivery system of ... |
PMC7335990 | core_pubmed_pmc | Integrated Quality by Design Approach for Developing Nanolipidic Drug Delivery Systems of Olmesartan Medoxomil with Enhanced Antihypertensive Action | Integrated Quality by Design Approach for Developing Nanolipidic Drug Delivery Systems of Olmesartan Medoxomil with Enhanced Antihypertensive Action Abstract Abstract Purpose: The present work endeavors to report a systematic approach of developing the lipidic self-nanoemulsifying formulation of olmesartan medoxomil (O... |
PMC12096638 | core_pubmed_pmc | Targeting heterogeneous depression with trazodone prolonged release: from neuropharmacology to clinical application | Targeting heterogeneous depression with trazodone prolonged release: from neuropharmacology to clinical application Abstract Aim This paper evaluates the clinical efficacy, safety, and practical implications of Trazodone Prolonged Release (PR) in managing depression, anxiety, and sleep disorders, with a focus on its mu... |
PMC4624361 | core_pubmed_pmc | Pharmacokinetic profile of phytoconstituent(s) isolated from medicinal plants—A comprehensive review | Pharmacokinetic profile of phytoconstituent(s) isolated from medicinal plants—A comprehensive review Abstract Abstract Herbal medicine, the backbone of traditional medicine, has played an important role in human health and welfare for a long period. Traditional therapeutic approaches of regional significance are found ... |
PMC9695373 | core_pubmed_pmc | Shedding a Light on Acyclovir Pharmacodynamics: A Retrospective Analysis on Pharmacokinetic/Pharmacodynamic Modelling of Acyclovir for the Treatment of Varicella Zoster Virus Infection in Immunocompromised Patients: A Pilot Study | Shedding a Light on Acyclovir Pharmacodynamics: A Retrospective Analysis on Pharmacokinetic/Pharmacodynamic Modelling of Acyclovir for the Treatment of Varicella Zoster Virus Infection in Immunocompromised Patients: A Pilot Study Abstract Abstract Background: Acyclovir and valacyclovir are used for the treatment and pr... |
PMC8213417 | core_pubmed_pmc | Application of physiologically based biopharmaceutics modeling to understand the impact of dissolution differences on in vivo performance of immediate release products: The case of bisoprolol | Application of physiologically based biopharmaceutics modeling to understand the impact of dissolution differences on in vivo performance of immediate release products: The case of bisoprolol Abstract Abstract Merck KGaA observed slight differences in the dissolution of Concor ® (bisoprolol) batches over the years. The... |
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