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PMC5896646 | core_pubmed_pmc | Bupivacaine in alginate and chitosan nanoparticles: an in vivo evaluation of efficacy, pharmacokinetics, and local toxicity | Bupivacaine in alginate and chitosan nanoparticles: an in vivo evaluation of efficacy, pharmacokinetics, and local toxicity Abstract Abstract Objective This study reports a preclinical evaluation of an alginate/chitosan nanoparticle formulation containing NovaBupi®, a racemic bupivacaine (BVC) containing 25% dextrobupi... |
PMC12838393 | core_pubmed_pmc | Vancomycin Dosing Regimen to Obtain the Target Area Under the Concentration–Time Curve, Which Provides an Early Treatment Response for Patients on Haemodialysis | Vancomycin Dosing Regimen to Obtain the Target Area Under the Concentration–Time Curve, Which Provides an Early Treatment Response for Patients on Haemodialysis Abstract Objectives : This study aimed to clarify the area under the curve (AUC) for obtaining better clinical outcomes and to demonstrate vancomycin dosing fo... |
PMC4333497 | core_pubmed_pmc | A first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies | A first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies Abstract Abstract Background: Heat-shock protein 990 (HSP990) is a potent and selective synthetic small-molecule HSP90 inhibitor. The primary objectives of this phase I first-in-... |
PMC7750811 | core_pubmed_pmc | Pharmacokinetics and Bioequivalence of Rasagiline Tablets in Chinese Healthy Subjects Under Fasting and Fed Conditions: An Open, Randomized, Single-Dose, Double-Cycle, Two-Sequence, Crossover Trial | Pharmacokinetics and Bioequivalence of Rasagiline Tablets in Chinese Healthy Subjects Under Fasting and Fed Conditions: An Open, Randomized, Single-Dose, Double-Cycle, Two-Sequence, Crossover Trial Abstract Objective: This study evaluated the pharmacokinetics, safety, and bioequivalence (BE) of two formulations of rasa... |
PMC11914374 | core_pubmed_pmc | Nanohydrogel of Curcumin/Berberine Co‐Crystals Induces Apoptosis via Dual Covalent/Noncovalent Inhibition of Caspases in Endometrial Cancer Cell Lines: The Synergy Between Pharmacokinetics and Pharmacodynamics | Nanohydrogel of Curcumin/Berberine Co‐Crystals Induces Apoptosis via Dual Covalent/Noncovalent Inhibition of Caspases in Endometrial Cancer Cell Lines: The Synergy Between Pharmacokinetics and Pharmacodynamics Abstract ABSTRACT Endometrial cancer remains a significant therapeutic challenge due to drug resistance and he... |
PMC6709426 | core_pubmed_pmc | NONMEM Tutorial Part I: Description of Commands and Options, With Simple Examples of Population Analysis | NONMEM Tutorial Part I: Description of Commands and Options, With Simple Examples of Population Analysis Abstract In this tutorial, the various components of NONMEM will be described, and the basic steps of setting up NONMEM control stream files and data files will be demonstrated. Some basic concepts of nonlinear mixe... |
PMC8255692 | core_pubmed_pmc | Successful Treatment of Airplane Headache with Rizatriptan: Case Report | Successful Treatment of Airplane Headache with Rizatriptan: Case Report Abstract Abstract Optimal management of airplane headache (AH) is still unresolved. A female, 53 years, complained of severe short-lasting jabbing pain attacks over the forehead and in the eyebrows, mainly on the left side, that occur during take-o... |
PMC9782495 | core_pubmed_pmc | Strategies Tackling Viral Replication and Inflammatory Pathways as Early Pharmacological Treatment for SARS-CoV-2 Infection: Any Potential Role for Ketoprofen Lysine Salt? | Strategies Tackling Viral Replication and Inflammatory Pathways as Early Pharmacological Treatment for SARS-CoV-2 Infection: Any Potential Role for Ketoprofen Lysine Salt? Abstract Abstract COVID-19 is an infective disease resulting in widespread respiratory and non-respiratory symptoms prompted by SARS-CoV-2 infection... |
PMC6089823 | core_pubmed_pmc | Moderate correlation between systemic IL‐6 responses and CRP with trough concentrations of voriconazole | Moderate correlation between systemic IL‐6 responses and CRP with trough concentrations of voriconazole Abstract Abstract Aims Voriconazole (VCZ) exhibits wide intrapatient pharmacokinetic variability, which is disadvantageous because of its narrow therapeutic range. A considerable part of this variation remains unexpl... |
PMC7911399 | core_pubmed_pmc | Pharmacokinetic Estimation Models-based Approach to Predict Clinical Implications for CYP Induction by Calcitriol in Human Cryopreserved Hepatocytes and HepaRG Cells | Pharmacokinetic Estimation Models-based Approach to Predict Clinical Implications for CYP Induction by Calcitriol in Human Cryopreserved Hepatocytes and HepaRG Cells Abstract Abstract Calcitriol, a vitamin D 3 metabolite, is approved for various indications because it is the bioactive form of vitamin D in the body. The... |
PMC10293153 | core_pubmed_pmc | A Randomized, Double-Blind, Parallel-Controlled Phase I Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of SCT510 to Bevacizumab (Avastin ® ) in Healthy Chinese Males | A Randomized, Double-Blind, Parallel-Controlled Phase I Study Comparing the Pharmacokinetics, Safety, and Immunogenicity of SCT510 to Bevacizumab (Avastin ® ) in Healthy Chinese Males Abstract Background SCT510 is a recombinant humanized monoclonal antibody targeting vascular endothelial growth factor (VEGF), which is ... |
PMC10857328 | core_pubmed_pmc | Utilization of Biopolymer-Based Lutein Emulsion as an Effective Delivery System to Improve Lutein Bioavailability in Neonatal Rats | Utilization of Biopolymer-Based Lutein Emulsion as an Effective Delivery System to Improve Lutein Bioavailability in Neonatal Rats Abstract Abstract Newborns’ eyes and brains are prone to oxidative stress. Lutein has antioxidant properties and is the main component of macular pigment essential for protecting the retina... |
PMC11784235 | core_pubmed_pmc | Cefiderocol pharmacokinetics during acute pulmonary exacerbations in hospitalized adult persons with cystic fibrosis | Cefiderocol pharmacokinetics during acute pulmonary exacerbations in hospitalized adult persons with cystic fibrosis Abstract ABSTRACT Persons with CF (pwCF) present altered pharmacokinetics (PK) and are often infected with multidrug-resistant (MDR) bacteria. Herein, we describe the PK of cefiderocol, a siderophore cep... |
PMC6322107 | core_pubmed_pmc | Clinically relevant drug interactions with multikinase inhibitors: a review | Clinically relevant drug interactions with multikinase inhibitors: a review Abstract Abstract Multikinase inhibitors (MKIs), including the tyrosine kinase inhibitors (TKIs), have rapidly become an established factor in daily (hemato)-oncology practice. Although the oral route of administration offers improved flexibili... |
PMC5108443 | core_pubmed_pmc | Pharmacodynamic and Pharmacokinetic Profiles of Sacubitril/Valsartan (LCZ696) in Patients with Heart Failure and Reduced Ejection Fraction | Pharmacodynamic and Pharmacokinetic Profiles of Sacubitril/Valsartan (LCZ696) in Patients with Heart Failure and Reduced Ejection Fraction Abstract Summary Aims Concomitant renin–angiotensin–aldosterone system blockade and natriuretic peptide system enhancement may provide unique therapeutic benefits to patients with h... |
PMC7829861 | core_pubmed_pmc | Pharmacokinetics and toxicity of carboplatin used for hyperthermic intraperitoneal chemotherapy (HIPEC) in treatment of epithelial ovarian cancer | Pharmacokinetics and toxicity of carboplatin used for hyperthermic intraperitoneal chemotherapy (HIPEC) in treatment of epithelial ovarian cancer Abstract Abstract Objectives Carboplatin is frequently used in various doses for hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of epithelial ovarian canc... |
PMC3049596 | core_pubmed_pmc | Phase II study of S-1 combined with oxaliplatin as therapy for patients with metastatic biliary tract cancer: influence of the CYP2A6 polymorphism on pharmacokinetics and clinical activity | Phase II study of S-1 combined with oxaliplatin as therapy for patients with metastatic biliary tract cancer: influence of the CYP2A6 polymorphism on pharmacokinetics and clinical activity Abstract Abstract Background: Advanced biliary cancer is often treated with fluoropyrimidine-based chemotherapy. In this study, we ... |
PMC10144002 | core_pubmed_pmc | Fabricating a PDA-Liposome Dual-Film Coated Hollow Mesoporous Silica Nanoplatform for Chemo-Photothermal Synergistic Antitumor Therapy | Fabricating a PDA-Liposome Dual-Film Coated Hollow Mesoporous Silica Nanoplatform for Chemo-Photothermal Synergistic Antitumor Therapy Abstract In this study, we synthesized hollow mesoporous silica nanoparticles (HMSNs) coated with polydopamine (PDA) and a D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS)-modif... |
PMC12046126 | core_pubmed_pmc | Pharmacodynamics of aztreonam/ceftazidime/avibactam and polymyxin B versus New Delhi MBL-producing Acinetobacter baumannii | Pharmacodynamics of aztreonam/ceftazidime/avibactam and polymyxin B versus New Delhi MBL-producing Acinetobacter baumannii Abstract Abstract Background Acinetobacter baumannii has become an increasingly urgent public health concern among global health agencies due to high rates of carbapenem resistance. Carbapenem-resi... |
PMC10838836 | core_pubmed_pmc | Ibrutinib Efficacy, Safety, and Pharmacokinetics in Chinese Patients with Relapsed or Refractory Waldenström’s Macroglobulinemia: A Multicenter, Single-Arm, Phase 4 Study | Ibrutinib Efficacy, Safety, and Pharmacokinetics in Chinese Patients with Relapsed or Refractory Waldenström’s Macroglobulinemia: A Multicenter, Single-Arm, Phase 4 Study Abstract Introduction Waldenström’s macroglobulinemia (WM) is a rare malignant B cell lymphoma which occurs in around 1–2% of all hematologic tumors.... |
PMC9293063 | core_pubmed_pmc | Comparison between physiologically based pharmacokinetic and population pharmacokinetic modelling to select paediatric doses of gepotidacin in plague | Comparison between physiologically based pharmacokinetic and population pharmacokinetic modelling to select paediatric doses of gepotidacin in plague Abstract Aims To develop physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) models to predict effective doses of gepotidacin in paediatri... |
PMC8412905 | core_pubmed_pmc | Assessment of Pharmacokinetics, Toxicity, and Biodistribution of a High Dose of Titanate Nanotubes Following Intravenous Injection in Mice: A Promising Nanosystem of Medical Interest | Assessment of Pharmacokinetics, Toxicity, and Biodistribution of a High Dose of Titanate Nanotubes Following Intravenous Injection in Mice: A Promising Nanosystem of Medical Interest Abstract Titanate nanotubes (TiNTs) produced by the static hydrothermal process present a promising nanosystem for nanomedicine. However,... |
PMC5153280 | core_pubmed_pmc | Use of bedaquiline and delamanid in diabetes patients: clinical and pharmacological considerations | Use of bedaquiline and delamanid in diabetes patients: clinical and pharmacological considerations Abstract Abstract Antituberculosis (anti-TB) treatment may be affected by both diabetes and hypoglycemic agents in patients with these 2 comorbidities. However, data supporting this conclusion relate only to standard anti... |
PMC9287219 | core_pubmed_pmc | Avelumab Dose Selection for Clinical Studies in Pediatric Patients with Solid Tumors | Avelumab Dose Selection for Clinical Studies in Pediatric Patients with Solid Tumors Abstract Background and Objective A phase I/II trial evaluated the safety, antitumor activity, and pharmacokinetics of avelumab (anti-PD-L1 antibody) in pediatric patients with refractory/relapsed solid tumors ( NCT03451825 ). This stu... |
PMC7584516 | core_pubmed_pmc | Simvastatin-Nicotinamide Co-Crystals: Formation, Pharmaceutical Characterization and in vivo Profile | Simvastatin-Nicotinamide Co-Crystals: Formation, Pharmaceutical Characterization and in vivo Profile Abstract Purpose To enhance the solubility and dissolution profile of simvastatin (SIM) through co-crystallization with varying ratios of nicotinamide (NIC) using various co-methods. Materials and Methods Twelve SIM:NIC... |
PMC9503184 | core_pubmed_pmc | Preparation, Characterization and Pharmacokinetics of Tolfenamic Acid-Loaded Solid Lipid Nanoparticles | Preparation, Characterization and Pharmacokinetics of Tolfenamic Acid-Loaded Solid Lipid Nanoparticles Abstract The clinical use of nonsteroidal anti-inflammatory drugs is limited by their poor water solubility, unstable absorption, and low bioavailability. Solid lipid nanoparticles (SLNs) exhibit high biocompatibility... |
PMC4010472 | core_pubmed_pmc | Pharmacokinetics and Efficacy of Topically Applied Nonsteroidal Anti-Inflammatory Drugs in Retinochoroidal Tissues in Rabbits | Pharmacokinetics and Efficacy of Topically Applied Nonsteroidal Anti-Inflammatory Drugs in Retinochoroidal Tissues in Rabbits Abstract Purpose To evaluate the pharmacokinetics and efficacy of topically applied nonsteroidal anti-inflammatory drugs (NSAIDs) in the retinochoroidal tissues of rabbits. Methods The cyclooxyg... |
PMC7202789 | core_pubmed_pmc | Non-invasive monitoring of pharmacodynamics during the skin wound healing process using multimodal optical microscopy | Non-invasive monitoring of pharmacodynamics during the skin wound healing process using multimodal optical microscopy Abstract Objective Impaired diabetic wound healing is one of the serious complications associated with diabetes. In patients with diabetes, this impairment is characterized by several physiological abno... |
PMC8707786 | core_pubmed_pmc | Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats | Pharmacokinetic Drug Interaction Study of Sorafenib and Morphine in Rats Abstract A combination of the tyrosine kinase inhibitor—sorafenib—and the opioid analgesic—morphine—can be found in the treatment of cancer patients. Since both are substrates of P-glycoprotein (P-gp), and sorafenib is also an inhibitor of P-gp, t... |
PMC12108195 | core_pubmed_pmc | Suitability of Piperacillin–Tazobactam for Treating Dogs Infected with Extended-Spectrum β-Lactamase-Producing Enterobacterales: Pharmacokinetic and Pharmacodynamic Analysis | Suitability of Piperacillin–Tazobactam for Treating Dogs Infected with Extended-Spectrum β-Lactamase-Producing Enterobacterales: Pharmacokinetic and Pharmacodynamic Analysis Abstract Abstract Background/Objectives : Piperacillin–tazobactam (TZP) is a potential alternative to carbapenems for the treatment of dogs infect... |
PMC8237186 | core_pubmed_pmc | Managing drug-induced QT prolongation in clinical practice | Managing drug-induced QT prolongation in clinical practice Abstract Abstract Many drug therapies are associated with prolongation of the QT interval. This may increase the risk of Torsades de Pointes (TdP), a potentially life-threatening cardiac arrhythmia. As the QT interval varies with a change in heart rate, various... |
PMC7919877 | core_pubmed_pmc | A randomized phase-I pharmacokinetic trial comparing the potential biosimilar tocilizumab (QX003S) with the reference product (Actemra ® ) in Chinese healthy subjects | A randomized phase-I pharmacokinetic trial comparing the potential biosimilar tocilizumab (QX003S) with the reference product (Actemra ® ) in Chinese healthy subjects Abstract Abstract Purpose QX003S is a biosimilar candidate for the reference tocilizumab, Actemra®. We investigated the tolerance, variability, and pharm... |
PMC10054647 | core_pubmed_pmc | Phenotyping Indices of CYP450 and P-Glycoprotein in Human Volunteers and in Patients Treated with Painkillers or Psychotropic Drugs | Phenotyping Indices of CYP450 and P-Glycoprotein in Human Volunteers and in Patients Treated with Painkillers or Psychotropic Drugs Abstract Drug-metabolizing enzymes and drug transporters are key determinants of drug pharmacokinetics and response. The cocktail-based cytochrome P450 (CYP) and drug transporter phenotypi... |
PMC9543887 | core_pubmed_pmc | Pharmacokinetic and pharmacodynamic equivalence of Biocon's biosimilar Insulin 70/30 with US‐licensed HUMULIN® 70/30 formulation in healthy subjects: Results from the RHINE‐3 ( R ecombinant H uman IN sulin E quivalence‐3) study | Pharmacokinetic and pharmacodynamic equivalence of Biocon's biosimilar Insulin 70/30 with US‐licensed HUMULIN® 70/30 formulation in healthy subjects: Results from the RHINE‐3 ( R ecombinant H uman IN sulin E quivalence‐3) study Abstract Abstract Aim To establish the pharmacokinetic (PK) and pharmacodynamic (PD) equival... |
PMC8344738 | core_pubmed_pmc | Targeting and pharmacology of an anti-IL13Rα2 antibody and antibody-drug conjugate in a melanoma xenograft model | Targeting and pharmacology of an anti-IL13Rα2 antibody and antibody-drug conjugate in a melanoma xenograft model Abstract ABSTRACT IL13Rα2 is a cell surface tumor antigen that is overexpressed in multiple tumor types. Here, we studied biodistribution and targeting potential of an anti-IL13Rα2 antibody (Ab) and anti-tum... |
PMC10135031 | core_pubmed_pmc | Should Airway Interstitial Fluid Be Used to Evaluate the Pharmacokinetics of Macrolide Antibiotics for Dose Regimen Determination in Respiratory Infection? | Should Airway Interstitial Fluid Be Used to Evaluate the Pharmacokinetics of Macrolide Antibiotics for Dose Regimen Determination in Respiratory Infection? Abstract Abstract Macrolide antibiotics are important drugs to combat infections. The pharmacokinetics (PK) of these drugs are essential for the determination of th... |
PMC12297031 | core_pubmed_pmc | Comparison of Pharmacokinetic/Pharmacodynamic Parameters and Clinical Outcomes of Vancomycin Administered in Two Different Dosage Regimens in Patients with Acute Kidney Injury | Comparison of Pharmacokinetic/Pharmacodynamic Parameters and Clinical Outcomes of Vancomycin Administered in Two Different Dosage Regimens in Patients with Acute Kidney Injury Abstract Abstract Background Vancomycin is commonly used in intensive care units (ICUs), but its optimal dosage in patients with acute kidney in... |
PMC6130457 | core_pubmed_pmc | Effects of Danshen tablets on pharmacokinetics of atorvastatin calcium in rats and its potential mechanism | Effects of Danshen tablets on pharmacokinetics of atorvastatin calcium in rats and its potential mechanism Abstract Abstract Context: Danshen tablets (DST), an effective traditional Chinese multi-herbal formula, are often combined with atorvastatin calcium (AC) for treating coronary heart disease in the clinic. Objecti... |
PMC3585842 | core_pubmed_pmc | Food Effects on the Pharmacokinetics of Doxylamine Hydrogen Succinate 25 mg Film-Coated Tablets | Food Effects on the Pharmacokinetics of Doxylamine Hydrogen Succinate 25 mg Film-Coated Tablets Abstract Background Doxylamine succinate, an ethanolamine-based antihistamine, is used in the short-term management of insomnia because of its sedative effects. The data available on the pharmacokinetic profile of doxylamine... |
PMC6853144 | core_pubmed_pmc | Clinical Trial in a Dish: Personalized Stem Cell–Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT‐Prolonging Drugs | Clinical Trial in a Dish: Personalized Stem Cell–Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT‐Prolonging Drugs Abstract Abstract Induced pluripotent stem cells (iPSCs) have shown promise in investigating donor‐specific phenotypes and pathologies. The iPSC‐derived cardiomyocytes (iPSC‐CMs)... |
PMC5790751 | core_pubmed_pmc | Development of a UPLC–MS/MS method for determination of pimavanserin tartrate in rat plasma: Application to a pharmacokinetic study | Development of a UPLC–MS/MS method for determination of pimavanserin tartrate in rat plasma: Application to a pharmacokinetic study Abstract Abstract A simple, rapid and sensitive method based on an ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) has been developed and validated for the de... |
PMC10045619 | core_pubmed_pmc | Vancomycin Sequestration in ST Filters: An In Vitro Study | Vancomycin Sequestration in ST Filters: An In Vitro Study Abstract Background. Sequestration of vancomycin in ST ® filters used in continuous renal therapy is a pending question. Direct vancomycin-ST ® interaction was assessed using the in vitro NeckEpur ® technology. Method. ST150 ® filter and Prismaflex dialyzer, Bax... |
PMC9923100 | core_pubmed_pmc | Pharmacokinetic and pharmacodynamic properties of pantoprazole in calves | Pharmacokinetic and pharmacodynamic properties of pantoprazole in calves Abstract Abstract Introduction Development of abomasal ulceration is a large concern, especially within calves; however, there is a paucity of research into the use of gastro protectants in ruminant species. Proton pump inhibitors, such as pantopr... |
PMC11904534 | core_pubmed_pmc | In vivo Pharmacokinetic/pharmacodynamic relationship of florfenicol in combination with doxycycline against Riemerella anatipestifer in ducks and the effect upon resistance development | In vivo Pharmacokinetic/pharmacodynamic relationship of florfenicol in combination with doxycycline against Riemerella anatipestifer in ducks and the effect upon resistance development Abstract Abstract Antimicrobial chemotherapy is necessary to control Riemerella anatipestifer (RA), among which florfenicol (FF) is reg... |
PMC8213416 | core_pubmed_pmc | The use of extrapolation based on modeling and simulation to support high‐dose regimens of ceftaroline fosamil in pediatric patients with complicated skin and soft‐tissue infections | The use of extrapolation based on modeling and simulation to support high‐dose regimens of ceftaroline fosamil in pediatric patients with complicated skin and soft‐tissue infections Abstract Abstract A model‐informed drug development approach was used to select ceftaroline fosamil high‐dose regimens for pediatric patie... |
PMC6451708 | core_pubmed_pmc | Clinical Pharmacology of Fast-Acting Insulin Aspart Versus Insulin Aspart Measured as Free or Total Insulin Aspart and the Relation to Anti-Insulin Aspart Antibody Levels in Subjects with Type 1 Diabetes Mellitus | Clinical Pharmacology of Fast-Acting Insulin Aspart Versus Insulin Aspart Measured as Free or Total Insulin Aspart and the Relation to Anti-Insulin Aspart Antibody Levels in Subjects with Type 1 Diabetes Mellitus Abstract Background Fast-acting insulin aspart (faster aspart) is an ultra-fast-acting formulation of insul... |
PMC6132366 | core_pubmed_pmc | Clinical Drug–Drug Interaction Potential of BFE1224, Prodrug of Antifungal Ravuconazole, Using Two Types of Cocktails in Healthy Subjects | Clinical Drug–Drug Interaction Potential of BFE1224, Prodrug of Antifungal Ravuconazole, Using Two Types of Cocktails in Healthy Subjects Abstract Abstract BFE1224, prodrug of ravuconazole, is a novel, once‐daily, oral, triazole antifungal drug, and currently in development for the treatment of onychomycosis. The clini... |
PMC12823314 | core_pubmed_pmc | Albumin Levels Are Predictive of Cachexia‐Induced Time‐Dependent Clearance of Therapeutic Antibodies: A Physiologically Based Pharmacokinetic Model of Durvalumab | Albumin Levels Are Predictive of Cachexia‐Induced Time‐Dependent Clearance of Therapeutic Antibodies: A Physiologically Based Pharmacokinetic Model of Durvalumab Abstract ABSTRACT Cachexia is a metabolic condition that accelerates the clearance of monoclonal antibodies in cancer patients and is a known mechanism causin... |
PMC7157554 | core_pubmed_pmc | Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis | Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis Abstract Abstract Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious... |
PMC10640773 | core_pubmed_pmc | Clinical Antiviral Efficacy of Remdesivir in Coronavirus Disease 2019: An Open-Label, Randomized Controlled Adaptive Platform Trial (PLATCOV) | Clinical Antiviral Efficacy of Remdesivir in Coronavirus Disease 2019: An Open-Label, Randomized Controlled Adaptive Platform Trial (PLATCOV) Abstract Abstract Background Uncertainty over the therapeutic benefit of parenteral remdesivir in coronavirus disease 2019 (COVID-19) has resulted in varying treatment guidelines... |
PMC12962400 | core_pubmed_pmc | Semi‐Physiological Population Pharmacokinetic Modeling of Oral and Intravenous Paracetamol to Quantify Presystemic Metabolism and Enterohepatic Recirculation | Semi‐Physiological Population Pharmacokinetic Modeling of Oral and Intravenous Paracetamol to Quantify Presystemic Metabolism and Enterohepatic Recirculation Abstract ABSTRACT Paracetamol (PCM) is extensively metabolized in the liver via glucuronidation, sulfation, and oxidation. Although oral and intravenous PCM are c... |
PMC12479722 | core_pubmed_pmc | Population Modeling of Factor IX Activity Following Administration of Fidanacogene Elaparvovec Gene Therapy in Participants with Hemophilia B | Population Modeling of Factor IX Activity Following Administration of Fidanacogene Elaparvovec Gene Therapy in Participants with Hemophilia B Abstract Abstract Background and Objective Fidanacogene elaparvovec (BEQVEZ™), an adeno-associated virus-based gene therapy approved for the treatment of hemophilia B, enables en... |
PMC9469084 | core_pubmed_pmc | Unravelling the pharmacokinetics of aflatoxin B1: In vitro determination of Michaelis–Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes | Unravelling the pharmacokinetics of aflatoxin B1: In vitro determination of Michaelis–Menten constants, intrinsic clearance and the metabolic contribution of CYP1A2 and CYP3A4 in pooled human liver microsomes Abstract Mycotoxins, fungal secondary metabolites, are ubiquitously present in food commodities. Acute exposure... |
PMC11327210 | core_pubmed_pmc | A first-in-human phase I trial of daily oral zelenirstat, a N-myristoyltransferase inhibitor, in patients with advanced solid tumors and relapsed/refractory B-cell lymphomas | A first-in-human phase I trial of daily oral zelenirstat, a N-myristoyltransferase inhibitor, in patients with advanced solid tumors and relapsed/refractory B-cell lymphomas Abstract Abstract Myristoylation, the N-terminal addition of the fatty acid myristate to proteins, regulates membrane-bound signal transduction pa... |
PMC4909797 | core_pubmed_pmc | No major effects of vitamin D 3 (1,25 dihydroxyvitamin D 3 ) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers | No major effects of vitamin D 3 (1,25 dihydroxyvitamin D 3 ) on absorption and pharmacokinetics of folic acid and fexofenadine in healthy volunteers Abstract Abstract Purpose In Caco-2 cells, folate uptake via the proton-coupled folate transporter (PCFT) increases significantly by a 3-day treatment with 1,25-dihydroxyv... |
PMC6102907 | core_pubmed_pmc | Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression | Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression Abstract Abstract Background Estimating the health effects of multi-pollutant mixtures is of increasing interest in environmental epidemiology. Recently, a new approach for estimating the health... |
PMC3793010 | core_pubmed_pmc | The influence of severe hypoalbuminemia on the half-life of vancomycin in elderly patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia | The influence of severe hypoalbuminemia on the half-life of vancomycin in elderly patients with methicillin-resistant Staphylococcus aureus hospital-acquired pneumonia Abstract Abstract Background Vancomycin (VCM) treatment outcomes depend on the characteristics of the patient, and it is well known that hypoalbuminemia... |
PMC9964148 | core_pubmed_pmc | Is a Lower Dose of Rivaroxaban Required for Asians? A Systematic Review of a Population Pharmacokinetics and Pharmacodynamics Analysis of Rivaroxaban | Is a Lower Dose of Rivaroxaban Required for Asians? A Systematic Review of a Population Pharmacokinetics and Pharmacodynamics Analysis of Rivaroxaban Abstract Rivaroxaban has been widely used to prevent and treat various thromboembolic diseases for more than a decade. However, whether a lower dose of rivaroxaban is req... |
PMC10083990 | core_pubmed_pmc | Asia‐Inclusive Clinical Research and Development Enabled by Translational Science and Quantitative Clinical Pharmacology: Toward a Culture That Challenges the Status Quo | Asia‐Inclusive Clinical Research and Development Enabled by Translational Science and Quantitative Clinical Pharmacology: Toward a Culture That Challenges the Status Quo Abstract Access lag to innovative therapies in Asian populations continues to present a challenge to global health. Recent progressive changes in the ... |
PMC10023865 | core_pubmed_pmc | Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife | Pharmacokinetic and pharmacodynamic considerations for treating sarcoptic mange with cross-relevance to Australian wildlife Abstract Abstract Sarcoptes scabiei is the microscopic burrowing mite responsible for sarcoptic mange, which is reported in approximately 150 mammalian species. In Australia, sarcoptic mange affec... |
PMC4709373 | core_pubmed_pmc | Model-Based Optimisation of Deferoxamine Chelation Therapy | Model-Based Optimisation of Deferoxamine Chelation Therapy Abstract Abstract Purpose Here we show how a model-based approach may be used to provide further insight into the role of clinical and demographic covariates on the progression of iron overload. The therapeutic effect of deferoxamine is used to illustrate the a... |
PMC6710524 | core_pubmed_pmc | Population pharmacokinetics of treosulfan in paediatric patients undergoing hematopoietic stem cell transplantation | Population pharmacokinetics of treosulfan in paediatric patients undergoing hematopoietic stem cell transplantation Abstract Abstract Aims Treosulfan is an alkylating agent increasingly used prior to haematopoietic stem cell transplantation. The aim of this study was to develop a population pharmacokinetic (PK) model o... |
PMC9862944 | core_pubmed_pmc | Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with Curcuma longa and Lepidium sativum | Changes in Pharmacokinetics and Pharmacodynamics of Losartan in Experimental Diseased Rats Treated with Curcuma longa and Lepidium sativum Abstract Abstract The current study investigated “pharmacodynamics and pharmacokinetics interactions” of losartan with Curcuma longa (CUR) and Lepidium sativum (LS) in hypertensive ... |
PMC12265818 | core_pubmed_pmc | Engineered IL-18 variants with half-life extension and improved stability for cancer immunotherapy | Engineered IL-18 variants with half-life extension and improved stability for cancer immunotherapy Abstract Abstract Background The pro-inflammatory cytokine, interleukin-18 (IL-18), plays an instrumental role in bolstering anti-tumor immunity. However, the therapeutic application of IL-18 has been limited due to its s... |
PMC8069539 | core_pubmed_pmc | Pharmacokinetic Disposition of Amiodarone When Given with an Intralipid Rescue Strategy | Pharmacokinetic Disposition of Amiodarone When Given with an Intralipid Rescue Strategy Abstract Abstract While the antiarrhythmic drug amiodarone is commonly used in clinical practice, it has a narrow therapeutic index that can lead to acute overdose. One proposed method to deal with this toxicity is lipid emulsion th... |
PMC7408095 | core_pubmed_pmc | Pharmacokinetic Interaction between Sorafenib and Atorvastatin, and Sorafenib and Metformin in Rats | Pharmacokinetic Interaction between Sorafenib and Atorvastatin, and Sorafenib and Metformin in Rats Abstract The tyrosine kinase inhibitor sorafenib is the first-line treatment for patients with hepatocellular carcinoma (HCC), in which hyperlipidemia and type 2 diabetes mellitus (T2DM) may often coexist. Protein transp... |
PMC9363357 | core_pubmed_pmc | Pharmacosimulation of delays and interruptions during administration of tirofiban: a systematic comparison between EU and US dosage regimens | Pharmacosimulation of delays and interruptions during administration of tirofiban: a systematic comparison between EU and US dosage regimens Abstract Tirofiban is a glycoproteine (GP) IIb/IIIa receptor antagonist, which inhibits platelet-platelet aggregation and is a potential adjunctive antithrombotic treatment in pat... |
PMC9303631 | core_pubmed_pmc | Effects of Renal Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites | Effects of Renal Impairment on the Pharmacokinetics of Abrocitinib and Its Metabolites Abstract Abstract Abrocitinib, an oral once‐daily Janus kinase 1 selective inhibitor, is under development for the treatment of atopic dermatitis. This phase 1, nonrandomized, open‐label, single‐dose study (NCT03660241) investigated ... |
PMC6282775 | core_pubmed_pmc | Effect of Hepatic Impairment on the Pharmacokinetics of Alectinib | Effect of Hepatic Impairment on the Pharmacokinetics of Alectinib Abstract Abstract Alectinib is approved and recommended as the preferred first‐line treatment for patients with anaplastic lymphoma kinase ( ALK )‐positive non–small cell lung cancer. The effect of hepatic impairment on the pharmacokinetics (PK) of alect... |
PMC10974226 | core_pubmed_pmc | Ranibizumab Port Delivery System in Neovascular Age-Related Macular Degeneration: Where Do We Stand? Overview of Pharmacokinetics, Clinical Results, and Future Directions | Ranibizumab Port Delivery System in Neovascular Age-Related Macular Degeneration: Where Do We Stand? Overview of Pharmacokinetics, Clinical Results, and Future Directions Abstract Abstract The ranibizumab (RBZ) port delivery system (PDS) is a device designed to continuously deliver RBZ in the vitreous chamber for the t... |
PMC6325993 | core_pubmed_pmc | Population Pharmacokinetic Analysis of Alirocumab in Healthy Volunteers or Hypercholesterolemic Subjects Using a Michaelis–Menten Approximation of a Target-Mediated Drug Disposition Model—Support for a Biologics License Application Submission: Part I | Population Pharmacokinetic Analysis of Alirocumab in Healthy Volunteers or Hypercholesterolemic Subjects Using a Michaelis–Menten Approximation of a Target-Mediated Drug Disposition Model—Support for a Biologics License Application Submission: Part I Abstract Abstract Background Alirocumab, a human monoclonal antibody,... |
PMC10122081 | core_pubmed_pmc | Pharmacokinetics of N , N -dimethyltryptamine in Humans | Pharmacokinetics of N , N -dimethyltryptamine in Humans Abstract Background and Objective N , N -dimethyltryptamine (DMT) is a psychedelic compound under development for the treatment of major depressive disorder (MDD). This study evaluated the preclinical and clinical pharmacokinetics and metabolism of DMT in healthy ... |
PMC8868263 | core_pubmed_pmc | Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep | Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep Abstract Abstract Simple Summary Anthelmintic drugs are among those most widely used in veterinary practice. The development of resistance to these drugs is a widespread problem, especially in small ruminants, and represents a serious thr... |
PMC11213218 | core_pubmed_pmc | Probabilistic Nested Model Selection in Pharmacokinetic Analysis of DCE-MRI Data in Animal Model of Cerebral Tumor | Probabilistic Nested Model Selection in Pharmacokinetic Analysis of DCE-MRI Data in Animal Model of Cerebral Tumor Abstract Abstract Purpose: Best current practice in the analysis of dynamic contrast enhanced (DCE)-MRI is to employ a voxel-by-voxel model selection from a hierarchy of nested models. This nested model se... |
PMC6222803 | core_pubmed_pmc | A Compositive Strategy to Study the Pharmacokinetics of TCMs: Taking Coptidis Rhizoma , and Coptidis Rhizoma - Glycyrrhizae Radix et Rhizoma as Examples | A Compositive Strategy to Study the Pharmacokinetics of TCMs: Taking Coptidis Rhizoma , and Coptidis Rhizoma - Glycyrrhizae Radix et Rhizoma as Examples Abstract Abstract Pharmacokinetic studies are crucial for elucidating the effective constituents and formula compatibility of traditional Chinese medicines (TCMs). How... |
PMC4930166 | core_pubmed_pmc | Pattern and Predictors of Medication Dosing Errors in Chronic Kidney Disease Patients in Pakistan: A Single Center Retrospective Analysis | Pattern and Predictors of Medication Dosing Errors in Chronic Kidney Disease Patients in Pakistan: A Single Center Retrospective Analysis Abstract Background Chronic kidney disease (CKD) alters the pharmacokinetic and pharmacodynamic response of various drugs and increases the risk of toxicity. The data regarding the p... |
PMC11638745 | core_pubmed_pmc | Pharmacokinetics, pharmacodynamics and bioavailability of dexmedetomidine nasal spray in healthy Chinese adults: A phase I clinical trial | Pharmacokinetics, pharmacodynamics and bioavailability of dexmedetomidine nasal spray in healthy Chinese adults: A phase I clinical trial Abstract Background Intranasal administration is a convenient route for drug delivery that can be applied for procedural sedation. However, there is currently limited exploration int... |
PMC8901636 | core_pubmed_pmc | Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2 V617F -induced myeloproliferative neoplasms | Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2 V617F -induced myeloproliferative neoplasms Abstract Abstract Janus kinase 2 (JAK2) hyperactivation by JAK2 V617F mutation leads to myeloproliferative neoplasms (MPNs) and targeting JAK2 could serve as a promising therapeutic ... |
PMC5153517 | core_pubmed_pmc | The HPLC assay of concentration of azithromycin from two different manufacturers in gingival crevicular fluid (GCF) | The HPLC assay of concentration of azithromycin from two different manufacturers in gingival crevicular fluid (GCF) Abstract Abstract Background: Azithromycin (AZM) is used in periodontal infections. The present study compared gingival crevicular fluid concentration of azithromycin of two pharmaceutical companies throu... |
PMC5395284 | core_pubmed_pmc | Simultaneous administration of fluoxetine and simvastatin ameliorates lipid profile, improves brain level of neurotransmitters, and increases bioavailability of simvastatin | Simultaneous administration of fluoxetine and simvastatin ameliorates lipid profile, improves brain level of neurotransmitters, and increases bioavailability of simvastatin Abstract Abstract Simvastatin (STT), a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, is widely prescribed for dyslipidemia, whereas fl... |
PMC10363420 | core_pubmed_pmc | Pharmacokinetic serum concentrations of VRC01 correlate with prevention of HIV-1 acquisition | Pharmacokinetic serum concentrations of VRC01 correlate with prevention of HIV-1 acquisition Abstract Summary Background The phase 2b proof-of-concept Antibody Mediated Prevention (AMP) trials showed that VRC01, an anti-HIV-1 broadly neutralising antibody (bnAb), prevented acquisition of HIV-1 sensitive to VRC01. To in... |
PMC11099157 | core_pubmed_pmc | ImmunoPET imaging of Trop2 in patients with solid tumours | ImmunoPET imaging of Trop2 in patients with solid tumours Abstract Abstract Accurately predicting and selecting patients who can benefit from targeted or immunotherapy is crucial for precision therapy. Trophoblast cell surface antigen 2 (Trop2) has been extensively investigated as a pan-cancer biomarker expressed in va... |
PMC8222727 | core_pubmed_pmc | Influence of Pyrexia on Pharmacokinetics of Azithromycin and Its Interaction With Tolfenamic Acid in Goats | Influence of Pyrexia on Pharmacokinetics of Azithromycin and Its Interaction With Tolfenamic Acid in Goats Abstract Abstract Azithromycin is a macrolide antimicrobial agent of the azalide group with a broad spectrum of activity against gram-negative and gram-positive bacterial organisms. Tolfenamic acid is a non-steroi... |
PMC12856045 | core_pubmed_pmc | 18 F-BPA as a surrogate tracer for BPA in BNCT: comparative analysis of transport mechanisms and biodistribution | 18 F-BPA as a surrogate tracer for BPA in BNCT: comparative analysis of transport mechanisms and biodistribution Abstract Abstract 4-Borono-L-phenylalanine (BPA) is a key 10 B carrier used in boron neutron capture therapy (BNCT), while its PET tracer analogue, 4-borono-2- 18 F-fluoro-L-phenylalanine ( 18 F-BPA), enable... |
PMC7075170 | core_pubmed_pmc | Metal-Based Nanoparticles as Antimicrobial Agents: An Overview | Metal-Based Nanoparticles as Antimicrobial Agents: An Overview Abstract Abstract Metal-based nanoparticles have been extensively investigated for a set of biomedical applications. According to the World Health Organization, in addition to their reduced size and selectivity for bacteria, metal-based nanoparticles have a... |
PMC7318569 | core_pubmed_pmc | A Drug‐Drug Interaction Study to Evaluate the Effect of TAS‐303 on CYP3A Activity in the Small Intestine and Liver | A Drug‐Drug Interaction Study to Evaluate the Effect of TAS‐303 on CYP3A Activity in the Small Intestine and Liver Abstract Abstract TAS‐303 (4‐piperidinyl 2,2‐diphenyl‐2‐[propoxy‐1,1,2,2,3,3,3‐ d 7 ] acetate hydrochloride) is a novel selective noradrenaline reuptake inhibitor being developed for the treatment of stres... |
PMC11625371 | core_pubmed_pmc | The attenuation of doxorubicin-induced testicular toxicity with improved testicular histoarchitecture of mice by the bioactive compounds in Solanum anomalum leaves: Experimental and computational studies | The attenuation of doxorubicin-induced testicular toxicity with improved testicular histoarchitecture of mice by the bioactive compounds in Solanum anomalum leaves: Experimental and computational studies Abstract Abstract Doxorubicin, as an antibiotic causes toxicity in human tissues through the generation of oxidant s... |
PMC9291800 | core_pubmed_pmc | Population pharmacokinetics and dose optimisation of colecalciferol in paediatric patients with chronic kidney disease | Population pharmacokinetics and dose optimisation of colecalciferol in paediatric patients with chronic kidney disease Abstract Aims The prevalence of vitamin D deficiency is high in children with chronic kidney disease (CKD). However, current dosing recommendations are based on limited pharmacokinetic (PK) data. This ... |
PMC12135056 | core_pubmed_pmc | Machine Learning Prediction and Validation of Plasma Concentration–Time Profiles | Machine Learning Prediction and Validation of Plasma Concentration–Time Profiles Abstract Abstract Recent research has increasingly focused on using machine learning for covariate selection in population pharmacokinetics (PPK) analysis. However, few studies have explored the prediction of plasma concentration profiles ... |
PMC5410230 | core_pubmed_pmc | Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma | Multiple spatially related pharmacophores define small molecule inhibitors of OLIG2 in glioblastoma Abstract Abstract Transcription factors (TFs) are a major class of protein signaling molecules that play key cellular roles in cancers such as the highly lethal brain cancer—glioblastoma (GBM). However, the development o... |
PMC12057357 | core_pubmed_pmc | Population pharmacokinetics study on nebulized and intravenous administration of polymyxin B in patients with pneumonia caused by multidrug-resistant gram-negative bacteria | Population pharmacokinetics study on nebulized and intravenous administration of polymyxin B in patients with pneumonia caused by multidrug-resistant gram-negative bacteria Abstract ABSTRACT Polymyxin B (PMB) remains a last-line therapeutic agent for multidrug-resistant gram-negative bacteria (MDR-GNB) infections. Howe... |
PMC6131119 | core_pubmed_pmc | Population Pharmacokinetic Modelling of Ceftazidime and Avibactam in the Plasma and Epithelial Lining Fluid of Healthy Volunteers | Population Pharmacokinetic Modelling of Ceftazidime and Avibactam in the Plasma and Epithelial Lining Fluid of Healthy Volunteers Abstract Abstract Objectives Our objective was to develop population pharmacokinetic (PK) models for ceftazidime and avibactam in the plasma and epithelial lining fluid (ELF) of healthy volu... |
PMC5710889 | core_pubmed_pmc | GSTA1 diplotypes affect busulfan clearance and toxicity in children undergoing allogeneic hematopoietic stem cell transplantation: a multicenter study | GSTA1 diplotypes affect busulfan clearance and toxicity in children undergoing allogeneic hematopoietic stem cell transplantation: a multicenter study Abstract Busulfan (BU) dose adjustment following therapeutic drug monitoring contributes to better outcome of hematopoietic stem cell transplantation (HSCT). Further imp... |
PMC10604031 | core_pubmed_pmc | Aerosol Inhalation Delivery of Ag Nanoparticles in Mice: Pharmacokinetics and Antibacterial Action | Aerosol Inhalation Delivery of Ag Nanoparticles in Mice: Pharmacokinetics and Antibacterial Action Abstract Abstract The aerosol inhalation delivery of composite particles consisting of Ag nanoparticles enveloped by polyvinylpyrrolidone was investigated in experiments with mice. An ultrasonic nebulizing system was crea... |
PMC4717259 | core_pubmed_pmc | Chemical Polysialylation and In Vivo Tetramerization Improve Pharmacokinetic Characteristics of Recombinant Human Butyrylcholinesterase-Based Bioscavengers | Chemical Polysialylation and In Vivo Tetramerization Improve Pharmacokinetic Characteristics of Recombinant Human Butyrylcholinesterase-Based Bioscavengers Abstract Abstract Organophosphate toxins (OPs) are the most toxic low-molecular compounds. The extremely potent toxicity of OPs is determined by their specificity t... |
PMC11811511 | core_pubmed_pmc | Bayesian Population Pharmacokinetic Modeling of Ondansetron for Neonatal Opioid Withdrawal Syndrome | Bayesian Population Pharmacokinetic Modeling of Ondansetron for Neonatal Opioid Withdrawal Syndrome Abstract ABSTRACT Ondansetron is an anti‐emetic 5‐HT3 receptor antagonist being investigated for treating neonatal opioid withdrawal syndrome (NOWS). Sparse PK data were analyzed from a multicenter, double‐blind clinical... |
PMC7212273 | core_pubmed_pmc | Phase I Study in Healthy Women of a Novel Antimycotic Vaginal Ovule Combining Econazole and Benzydamine | Phase I Study in Healthy Women of a Novel Antimycotic Vaginal Ovule Combining Econazole and Benzydamine Abstract Abstract Purpose A novel fixed-dose combination of 150 mg of econazole with 6 mg of benzydamine formulated in vaginal ovules was investigated in a randomised, double-blind, four-parallel group, tolerability,... |
PMC8603542 | core_pubmed_pmc | Protocol: Pentoxifylline optimal dose finding trial in preterm neonates with suspected late onset sepsis (PTX-trial) | Protocol: Pentoxifylline optimal dose finding trial in preterm neonates with suspected late onset sepsis (PTX-trial) Abstract Background Late onset sepsis is a leading cause of death and morbidity in preterm infants. Despite optimal antibiotic treatment, sepsis related mortality and morbidity is still high. Pentoxifyll... |
PMC9666938 | core_pubmed_pmc | Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti- Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa -colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial | Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti- Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa -colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial Abstract Abstract Background Ventilator-associated pneumonia caused by P... |
PMC10741625 | core_pubmed_pmc | Combination Drug Therapy for the Management of Chronic Neuropathic Pain | Combination Drug Therapy for the Management of Chronic Neuropathic Pain Abstract Abstract Chronic neuropathic pain (NP) is an increasingly prevalent disease and leading cause of disability which is challenging to treat. Several distinct classes of drugs are currently used for the treatment of chronic NP, but each drug ... |
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