id stringlengths 9 11 | source stringclasses 1
value | title stringlengths 15 560 | text stringlengths 2k 153k |
|---|---|---|---|
PMC4213380 | core_pubmed_pmc | Pediatric Microdose Study of [ 14 C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept | Pediatric Microdose Study of [ 14 C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept Abstract Background Pediatric drug development is hampered by practical, ethical, and scientific challenges. Microdosing is a promising new method to obtain pharmacokinetic data in children wit... |
PMC6434040 | core_pubmed_pmc | Complementary medicine use during cancer treatment and potential herb-drug interactions from a cross-sectional study in an academic centre | Complementary medicine use during cancer treatment and potential herb-drug interactions from a cross-sectional study in an academic centre Abstract Abstract Complementary medicine (CM) is used by one third to one half of cancer patients throughout the world. The objective of this study was to describe the prevalence of... |
PMC9860669 | core_pubmed_pmc | Penetration of Enrofloxacin in Aqueous Humour of Avian Eyes | Penetration of Enrofloxacin in Aqueous Humour of Avian Eyes Abstract Simple Summary Scientific information on the suitability of antibiotics for the treatment of intraocular bacterial infections in birds is lacking so far. Because the anatomical features of avian eyes differ from those in mammals, data obtained in mamm... |
PMC6018301 | core_pubmed_pmc | Dual-channel NIR activatable theranostic prodrug for in vivo spatiotemporal tracking thiol-triggered chemotherapy † †Electronic supplementary information (ESI) available: Detailed experimental procedures, characterizations, supplementary optical spectra and figures. See DOI: 10.1039/c6sc00970k | Dual-channel NIR activatable theranostic prodrug for in vivo spatiotemporal tracking thiol-triggered chemotherapy † †Electronic supplementary information (ESI) available: Detailed experimental procedures, characterizations, supplementary optical spectra and figures. See DOI: 10.1039/c6sc00970k Abstract Real-time tracki... |
PMC9995914 | core_pubmed_pmc | Coicis Semen for the treatment of malignant tumors of the female reproductive system: A review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics, and pharmacodynamics | Coicis Semen for the treatment of malignant tumors of the female reproductive system: A review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics, and pharmacodynamics Abstract Abstract Coicis Semen is an important food product and traditional Chinese medicine (TCM) derived from the dried and matur... |
PMC3600727 | core_pubmed_pmc | Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK-875 in Subjects With Type 2 Diabetes Mellitus | Pharmacometric Approaches to Guide Dose Selection of the Novel GPR40 Agonist TAK-875 in Subjects With Type 2 Diabetes Mellitus Abstract The G-protein-coupled receptor 40 agonist (GPR40) TAK-875 is being developed as an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus. P... |
PMC8143323 | core_pubmed_pmc | Effects of Magnesium, Calcium, and Aluminum Chelation on Fluoroquinolone Absorption Rate and Bioavailability: A Computational Study | Effects of Magnesium, Calcium, and Aluminum Chelation on Fluoroquinolone Absorption Rate and Bioavailability: A Computational Study Abstract Abstract Fluoroquinolones (FQs) are a widespread class of broad-spectrum antibiotics prescribed as a first line of defense, and, in some cases, as the only treatment against bacte... |
PMC5901045 | core_pubmed_pmc | Delafloxacin Pharmacokinetics in Subjects With Varying Degrees of Renal Function | Delafloxacin Pharmacokinetics in Subjects With Varying Degrees of Renal Function Abstract Abstract Delafloxacin, a fluoroquinolone, has activity against gram‐positive organisms including methicillin‐resistant Staphylococcus aureus and fluoroquinolone‐susceptible and –resistant gram‐negative organisms. This study was co... |
PMC8127833 | core_pubmed_pmc | Preparation, Pharmacokinetics, and Antitumor Potential of Miltefosine-Loaded Nanostructured Lipid Carriers | Preparation, Pharmacokinetics, and Antitumor Potential of Miltefosine-Loaded Nanostructured Lipid Carriers Abstract Background The purpose of this study was to investigate the suitability of nanostructured lipid carriers (NLCs) loaded with miltefosine (HePC) as an anticancer drug for the treatment of breast cancer. Met... |
PMC8016787 | core_pubmed_pmc | Nicotine Population Pharmacokinetics in Healthy Smokers After Intravenous, Oral, Buccal and Transdermal Administration | Nicotine Population Pharmacokinetics in Healthy Smokers After Intravenous, Oral, Buccal and Transdermal Administration Abstract Background In 4 decades, numerous nicotine replacement therapy products have been developed. Population pharmacokinetic models can support exposure–response modeling and inform nicotine replac... |
PMC3511404 | core_pubmed_pmc | Synergistic Action of Gentamicin and Bacteriophage in a Continuous Culture Population of Staphylococcus aureus | Synergistic Action of Gentamicin and Bacteriophage in a Continuous Culture Population of Staphylococcus aureus Abstract Abstract With the increasing frequency of antibiotic resistance and the decreasing frequency of new antibiotics entering the market, interest has returned to developing bacteriophage as a therapeutic ... |
PMC9831710 | core_pubmed_pmc | Traditional Uses, Bioactive Compounds, and Pharmacological Investigations of Calendula arvensis L.: A Comprehensive Review | Traditional Uses, Bioactive Compounds, and Pharmacological Investigations of Calendula arvensis L.: A Comprehensive Review Abstract Abstract Calendula arvensis L. (Asteraceae) is a famous ornamental and medicinal plant widely distributed in Mediterranean countries and the southern region of Europe. This reputed species... |
PMC12199288 | core_pubmed_pmc | Validated LC‐MS/MS Method for Quantifying the Antiparasitic Nitroimidazole DNDI‐0690 in Preclinical Target Site PK/PD Studies | Validated LC‐MS/MS Method for Quantifying the Antiparasitic Nitroimidazole DNDI‐0690 in Preclinical Target Site PK/PD Studies Abstract ABSTRACT Understanding the target site pharmacokinetics (PK) of the nitroimidazole analog DNDI‐0690, a potential drug for the neglected parasitic disease leishmaniasis, is important due... |
PMC12196043 | core_pubmed_pmc | In Vivo PK-PD and Drug–Drug Interaction Study of Dorzagliatin for the Management of PI3Kα Inhibitor-Induced Hyperglycemia | In Vivo PK-PD and Drug–Drug Interaction Study of Dorzagliatin for the Management of PI3Kα Inhibitor-Induced Hyperglycemia Abstract Objectives: The anticancer effects of PI3Kα inhibitors (PI3Ki) are constrained by their hyperglycemic side effects, while the efficacy of conventional hypoglycemic agents, such as insulin, ... |
PMC9303772 | core_pubmed_pmc | Population Pharmacokinetics and Exposure‐Response Relationships of Astegolimab in Patients With Severe Asthma | Population Pharmacokinetics and Exposure‐Response Relationships of Astegolimab in Patients With Severe Asthma Abstract Abstract Astegolimab is a fully human immunoglobulin G2 monoclonal antibody that binds to the ST2 receptor and blocks the interleukin‐33 signaling. It was evaluated in patients with uncontrolled severe... |
PMC8952437 | core_pubmed_pmc | Pharmacokinetics of Curative Tranexamic Acid in Parturients Undergoing Cesarean Delivery | Pharmacokinetics of Curative Tranexamic Acid in Parturients Undergoing Cesarean Delivery Abstract The aim of this study was to evaluate the population pharmacokinetics of tranexamic acid (TXA) administered intravenously at a single dose of 0.5 or 1 g in parturients undergoing active hemorrhagic cesarean delivery and to... |
PMC4049432 | core_pubmed_pmc | Disease progression model for Clinical Dementia Rating–Sum of Boxes in mild cognitive impairment and Alzheimer’s subjects from the Alzheimer’s Disease Neuroimaging Initiative | Disease progression model for Clinical Dementia Rating–Sum of Boxes in mild cognitive impairment and Alzheimer’s subjects from the Alzheimer’s Disease Neuroimaging Initiative Abstract Abstract Background The objective of this analysis was to develop a nonlinear disease progression model, using an expanded set of covari... |
PMC8309003 | core_pubmed_pmc | Short Onset and Enhanced Analgesia Following Nasal Administration of Non-Controlled Drugs in Nanovesicular Systems | Short Onset and Enhanced Analgesia Following Nasal Administration of Non-Controlled Drugs in Nanovesicular Systems Abstract Nasal nanovesicular delivery systems (NVS) containing the noncontrolled analgesic drugs Ketoprofen, Butorphanol or Tramadol, incorporated in a phospholipid nanovesicular carrier, were designed and... |
PMC9044835 | core_pubmed_pmc | A randomised placebo-controlled, double-blind phase II study to explore the safety, efficacy, and pharmacokinetics of sonlicromanol in children with genetically confirmed mitochondrial disease and motor symptoms (“KHENERGYC”) | A randomised placebo-controlled, double-blind phase II study to explore the safety, efficacy, and pharmacokinetics of sonlicromanol in children with genetically confirmed mitochondrial disease and motor symptoms (“KHENERGYC”) Abstract Abstract Background Methods The KHENERGYC trial will be a phase II, randomised, doubl... |
PMC8891207 | core_pubmed_pmc | Pre- and Postnatal Maturation are Important for Fentanyl Exposure in Preterm and Term Newborns: A Pooled Population Pharmacokinetic Study | Pre- and Postnatal Maturation are Important for Fentanyl Exposure in Preterm and Term Newborns: A Pooled Population Pharmacokinetic Study Abstract Abstract Background and Objective Fentanyl is an opioid commonly used to prevent and treat severe pain in neonates; however, its use is off label and mostly based on bodywei... |
PMC5928397 | core_pubmed_pmc | Behavioural, Pharmacokinetic, Metabolic, and Hyperthermic Profile of 3,4-Methylenedioxypyrovalerone (MDPV) in the Wistar Rat | Behavioural, Pharmacokinetic, Metabolic, and Hyperthermic Profile of 3,4-Methylenedioxypyrovalerone (MDPV) in the Wistar Rat Abstract 3,4-methylenedioxypyrovalerone (MDPV) is a potent pyrovalerone cathinone that is substituted for amphetamines by recreational users. We report a comprehensive and detailed description of... |
PMC11604989 | core_pubmed_pmc | Pharmacokinetics of infigratinib and its active metabolites in Chinese patients with advanced gastric cancer harboring FGFR2 gene amplification | Pharmacokinetics of infigratinib and its active metabolites in Chinese patients with advanced gastric cancer harboring FGFR2 gene amplification Abstract Abstract Infigratinib, an FGFR1‐3 selective oral tyrosine kinase inhibitor, has shown clinical activity in cancers with FGFR alterations. The pharmacokinetics (PK) of ... |
PMC6061414 | core_pubmed_pmc | Pharmacokinetics of Fentanyl Sublingual Spray in Opioid-Naïve Participants: Results of a Phase 1, Multiple Ascending Dose Study | Pharmacokinetics of Fentanyl Sublingual Spray in Opioid-Naïve Participants: Results of a Phase 1, Multiple Ascending Dose Study Abstract Abstract Background and Objectives Fentanyl sublingual spray may be a viable alternative to intravenous (IV) opioids for the treatment of acute pain. As patients with acute pain may i... |
PMC12030207 | core_pubmed_pmc | Physiologically-Based Biopharmaceutics Modeling for Ibuprofen: Identifying Key Formulation Parameter and Virtual Bioequivalence Assessment | Physiologically-Based Biopharmaceutics Modeling for Ibuprofen: Identifying Key Formulation Parameter and Virtual Bioequivalence Assessment Abstract Background : Physiologically based pharmacokinetic (PBPK) modeling for biopharmaceutics applications (i.e., physiologically based biopharmaceutics modeling (PBBM)) enables ... |
PMC12460856 | core_pubmed_pmc | Effect of Severe Renal Impairment on Dordaviprone (ONC201) Pharmacokinetics | Effect of Severe Renal Impairment on Dordaviprone (ONC201) Pharmacokinetics Abstract Abstract Background and Objective Dordaviprone (ONC201) is a novel small molecule with antitumor effects in patients with glioma. The major elimination pathway of dordaviprone is metabolism via cytochrome P450 (CYP) 3A4. This study was... |
PMC10099993 | core_pubmed_pmc | Pharmacokinetics of the Multi‐kinase Inhibitor Pexidartinib: Mass Balance and Dose Proportionality | Pharmacokinetics of the Multi‐kinase Inhibitor Pexidartinib: Mass Balance and Dose Proportionality Abstract Abstract Pexidartinib is an oral small‐molecule tyrosine kinase inhibitor that selectively targets colony‐stimulating factor 1 receptor. Two phase 1 single‐center trials were conducted in healthy subjects to dete... |
PMC8878365 | core_pubmed_pmc | Abuse Potential of Cathinones in Humans: A Systematic Review | Abuse Potential of Cathinones in Humans: A Systematic Review Abstract Abstract Introduction and objective : Assessing the abuse potential of new substances with central nervous system activity is essential for preventing possible risks of misuse and addiction. The same methodology is recommended for the evaluation of t... |
PMC5883931 | core_pubmed_pmc | Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders | Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders Abstract Thymoquinone (TQ) is an active ingredient isolated from Nigella sativa and has various pharmacological activities, such as protection against oxidative stress, inflammation, and infections. In addition, it might be... |
PMC11451929 | core_pubmed_pmc | Current opinion: antiretrovirals during pregnancy and breastfeeding | Current opinion: antiretrovirals during pregnancy and breastfeeding Abstract Abstract Purpose of review To review the most important literature from the past 2 years on the pharmacokinetics of antiretrovirals in pregnancy, placental transfer, and breastmilk. Recent findings Concentrations of antiretrovirals frequently ... |
PMC10804103 | core_pubmed_pmc | Pharmacokinetics of vitamin dosage forms: A complete overview | Pharmacokinetics of vitamin dosage forms: A complete overview Abstract Abstract Vitamins are crucial for sustaining life because they play an essential role in numerous physiological processes. Vitamin deficiencies can lead to a wide range of severe health issues. In this context, there is a need to administer vitamin ... |
PMC6972638 | core_pubmed_pmc | Dupilumab in adolescents with uncontrolled moderate‐to‐severe atopic dermatitis: results from a phase IIa open‐label trial and subsequent phase III open‐label extension † | Dupilumab in adolescents with uncontrolled moderate‐to‐severe atopic dermatitis: results from a phase IIa open‐label trial and subsequent phase III open‐label extension † Abstract Summary Background Dupilumab (monoclonal antibody inhibiting IL‐4/IL‐13 signalling) is approved for use in adolescents aged ≥ 12 years with ... |
PMC3442744 | core_pubmed_pmc | Liposomal bupivacaine: a review of a new bupivacaine formulation | Liposomal bupivacaine: a review of a new bupivacaine formulation Abstract Abstract Many attempts have been made to increase the duration of local anesthetic action. One avenue of investigation has focused on encapsulating local anesthetics within carrier molecules to increase their residence time at the site of action.... |
PMC7874128 | core_pubmed_pmc | Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats | Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats Abstract Berberine, a well-known alkaloid, has been proved to possess various pharmacological activities. Previous studies demonstrated that berberine could be extensively metabolized and the metabolites also contributed to its therapeutic eff... |
PMC3553339 | core_pubmed_pmc | Development of a Physiologically Based Computational Kidney Model to Describe the Renal Excretion of Hydrophilic Agents in Rats | Development of a Physiologically Based Computational Kidney Model to Describe the Renal Excretion of Hydrophilic Agents in Rats Abstract A physiologically based kidney model was developed to analyze the renal excretion and kidney exposure of hydrophilic agents, in particular contrast media, in rats. In order to study t... |
PMC11187257 | core_pubmed_pmc | Pharmacokinetic evaluation of paclitaxel, albumin-binding paclitaxel, and liposomal-encapsulated albumin-binding paclitaxel upon gastric subserosal administration | Pharmacokinetic evaluation of paclitaxel, albumin-binding paclitaxel, and liposomal-encapsulated albumin-binding paclitaxel upon gastric subserosal administration Abstract Abstract Introduction: Systemic chemotherapy is typically administered following radical gastrectomy for advanced stage. To attenuate systemic side ... |
PMC9027532 | core_pubmed_pmc | Preclinical Pharmacokinetic Studies of a Novel Diuretic Inhibiting Urea Transporters | Preclinical Pharmacokinetic Studies of a Novel Diuretic Inhibiting Urea Transporters Abstract Abstract Urea transporter (UT) inhibitors are a class of promising novel diuretics that do not cause the imbalance of Na + , K + , Cl − , and other electrolytes. In our previous studies, 25a , a promising diuretic candidate in... |
PMC6694490 | core_pubmed_pmc | Safety, tolerability, pharmacokinetics, and pharmacodynamics of the afucosylated, humanized anti-EPHA2 antibody DS-8895a: a first-in-human phase I dose escalation and dose expansion study in patients with advanced solid tumors | Safety, tolerability, pharmacokinetics, and pharmacodynamics of the afucosylated, humanized anti-EPHA2 antibody DS-8895a: a first-in-human phase I dose escalation and dose expansion study in patients with advanced solid tumors Abstract Background Erythropoietin-producing hepatocellular receptor A2 (EPHA2) is overexpres... |
PMC8745373 | core_pubmed_pmc | QiShenYiQi pills, a Chinese patent medicine, increase bioavailability of atorvastatin by inhibiting Mrp2 expression in rats | QiShenYiQi pills, a Chinese patent medicine, increase bioavailability of atorvastatin by inhibiting Mrp2 expression in rats Abstract Abstract Context Atorvastatin (ATV) and QiShenYiQi pills (QSYQ), a Chinese patent medicine, are often co-prescribed to Chinese cardiovascular patients. The effects of QSYQ on the pharmaco... |
PMC8301574 | core_pubmed_pmc | A pharmacokinetic simulation study to assess the performance of a sparse blood sampling approach to quantify early drug exposure | A pharmacokinetic simulation study to assess the performance of a sparse blood sampling approach to quantify early drug exposure Abstract Abstract Estimating early exposure of drugs used for the treatment of emergent conditions is challenging because blood sampling to measure concentrations is difficult. The objective ... |
PMC7870753 | core_pubmed_pmc | Population pharmacokinetics of ATR inhibitor berzosertib in phase I studies for different cancer types | Population pharmacokinetics of ATR inhibitor berzosertib in phase I studies for different cancer types Abstract Purpose Berzosertib (formerly M6620) is the first-in-class inhibitor of ataxia–telangiectasia and Rad3-related protein, a key component of the DNA damage response, and being developed in combination with chem... |
PMC10061170 | core_pubmed_pmc | Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia | Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia Abstract Abstract Background Acetaminophen has been evaluated in horses for treatment of musculoskeletal pain but not as an antipyretic. Objectives To determine the pharmacokinetics a... |
PMC6099471 | core_pubmed_pmc | Exposure‐safety and efficacy response relationships and population pharmacokinetics of eslicarbazepine acetate | Exposure‐safety and efficacy response relationships and population pharmacokinetics of eslicarbazepine acetate Abstract Objectives Eslicarbazepine acetate ( ESL ) is a once‐daily ( QD ) oral antiepileptic drug ( AED ) for focal‐onset seizures ( FOS ). Pharmacokinetic ( PK ) and pharmacodynamic ( PD ) models were develo... |
PMC3948684 | core_pubmed_pmc | Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid | Approaches to Improve the Oral Bioavailability and Effects of Novel Anticancer Drugs Berberine and Betulinic Acid Abstract Abstract Background The poor bioavailability of Berberine (BBR) and Betulinic acid (BA) limits the development of these promising anticancer agents for clinical use. In the current study, BBR and B... |
PMC8602150 | core_pubmed_pmc | Evaluation of the Robustness of Therapeutic Drug Monitoring Coupled with Bayesian Forecasting of Busulfan with Regard to Inaccurate Documentation | Evaluation of the Robustness of Therapeutic Drug Monitoring Coupled with Bayesian Forecasting of Busulfan with Regard to Inaccurate Documentation Abstract Abstract Background Inaccurate documentation of sampling and infusion times is a potential source of error in personalizing busulfan doses using therapeutic drug mon... |
PMC11984268 | core_pubmed_pmc | A Phase Ia/b study of MEK1/2 inhibitor binimetinib with MET inhibitor crizotinib in patients with RAS mutant advanced colorectal cancer (MErCuRIC) | A Phase Ia/b study of MEK1/2 inhibitor binimetinib with MET inhibitor crizotinib in patients with RAS mutant advanced colorectal cancer (MErCuRIC) Abstract Background Targeting RAS mutant (MT) colorectal cancer (CRC) remains a difficult challenge, mainly due to the pervasiveness of RAS/MEK-mediated feedback loops. Prec... |
PMC9587945 | core_pubmed_pmc | Efficacy and safety of talazoparib in Japanese patients with germline BRCA- mutated locally advanced or metastatic breast cancer: results of the phase 1 dose-expansion study | Efficacy and safety of talazoparib in Japanese patients with germline BRCA- mutated locally advanced or metastatic breast cancer: results of the phase 1 dose-expansion study Abstract Background Talazoparib, a poly(ADP-ribose) polymerase enzyme inhibitor, is approved for the treatment of patients with germline BRCA1/2 (... |
PMC10755240 | core_pubmed_pmc | The emergence, implementation, and future growth of pharmacogenomics in psychiatry: a narrative review | The emergence, implementation, and future growth of pharmacogenomics in psychiatry: a narrative review Abstract Abstract Psychotropic medication efficacy and tolerability are critical treatment issues faced by individuals with psychiatric disorders and their healthcare providers. For some people, it can take months to ... |
PMC9662201 | core_pubmed_pmc | Application of physiologically‐based pharmacokinetic model approach to predict pharmacokinetics and drug–drug interaction of rivaroxaban: A case study of rivaroxaban and carbamazepine | Application of physiologically‐based pharmacokinetic model approach to predict pharmacokinetics and drug–drug interaction of rivaroxaban: A case study of rivaroxaban and carbamazepine Abstract Abstract Rivaroxaban (RIV; Xarelto; Janssen Pharmaceuticals, Beerse, Belgium) is one of the direct oral anticoagulants. The dru... |
PMC6941225 | core_pubmed_pmc | Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity | Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity Abstract The broadly neutralizing anti-HIV antibody, 10-1074, is a highly somatically hypermutated IgG1 being developed for prophylaxis in sub-Saharan Africa. A serie... |
PMC5413024 | core_pubmed_pmc | Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo | Mechanistic insights into the more potent effect of KP-54 compared to KP-10 in vivo Abstract Kisspeptins regulate the mammalian reproductive axis by stimulating release of gonadotrophin releasing hormone (GnRH). Different length kisspeptins (KP) are found of 54, 14, 13 or 10 amino-acids which share a common C-terminal ... |
PMC10772055 | core_pubmed_pmc | Pharmacokinetic properties of a new sustained-release pregabalin tablet in subjects with reduced renal function | Pharmacokinetic properties of a new sustained-release pregabalin tablet in subjects with reduced renal function Abstract Abstract A new sustained-release (SR) pregabalin tablet, YHD1119, was formulated for once-daily dosing. In the current study, we aimed to evaluate the pharmacokinetics of YHD1119 tablets in patients ... |
PMC10819458 | core_pubmed_pmc | Using Pharmacokinetic–Pharmacodynamic Modeling to Study the Main Active Substances of the Anticancer Effect in Mice from Panax ginseng – Ophiopogon japonicus | Using Pharmacokinetic–Pharmacodynamic Modeling to Study the Main Active Substances of the Anticancer Effect in Mice from Panax ginseng – Ophiopogon japonicus Abstract Abstract Ginseng Radix et Rhizoma Rubra ( Panax ginseng C.A. Mey, Hongshen, in Chinese) and Ophiopogonis Radix ( Ophiopogon japonicus (L.f) Ker-Gawl., Ma... |
PMC9657028 | core_pubmed_pmc | Review of the Existing Translational Pharmacokinetics Modeling Approaches Specific to Monoclonal Antibodies (mAbs) to Support the First-In-Human (FIH) Dose Selection | Review of the Existing Translational Pharmacokinetics Modeling Approaches Specific to Monoclonal Antibodies (mAbs) to Support the First-In-Human (FIH) Dose Selection Abstract The interest in therapeutic monoclonal antibodies (mAbs) has continuously growing in several diseases. However, their pharmacokinetics (PK) is co... |
PMC9227779 | core_pubmed_pmc | Changes in Thyroid Metabolites after Liothyronine Administration: A Secondary Analysis of Two Clinical Trials That Incorporated Pharmacokinetic Data | Changes in Thyroid Metabolites after Liothyronine Administration: A Secondary Analysis of Two Clinical Trials That Incorporated Pharmacokinetic Data Abstract We examined relationships between thyroid hormone (TH) metabolites in humans by measuring 3,5-diiodothyronine (3,5-T2) and 3-iodothyronamine (3-T1AM) levels after... |
PMC12316956 | core_pubmed_pmc | Pharmacokinetic variability of 20(S)-protopanaxadiol-type ginsenosides Rb1, rd, and compound K from Korean red ginseng in experimental rodents | Pharmacokinetic variability of 20(S)-protopanaxadiol-type ginsenosides Rb1, rd, and compound K from Korean red ginseng in experimental rodents Abstract Korean red ginseng (KRG, Panax ginseng C.A. Meyer) contains ginsenosides, which are metabolized into active metabolites with various pharmacological effects. This study... |
PMC12068406 | core_pubmed_pmc | A Natural Compound Methylnissolin: Physicochemical Properties, Pharmacological Activities, Pharmacokinetics and Resource Development | A Natural Compound Methylnissolin: Physicochemical Properties, Pharmacological Activities, Pharmacokinetics and Resource Development Abstract Abstract Methylnissolin (also known as Astrapterocarpan) is an isoflavonoid compound featuring a pterocarpan core structure. To date, leguminous plants of the genus Astragalus re... |
PMC11705039 | core_pubmed_pmc | Potential Risks from Cannabis-Infused Beverages: A Critical Review | Potential Risks from Cannabis-Infused Beverages: A Critical Review Abstract Abstract Although Canada legalized cannabis beverages in 2019, most available research on acute cannabis intoxication derives from dried flower and edible products. The distinct bioavailability and pharmacokinetic properties of phytocannabinoid... |
PMC7027979 | core_pubmed_pmc | Changing Body Weight–Based Dosing to a Flat Dose for Avelumab in Metastatic Merkel Cell and Advanced Urothelial Carcinoma | Changing Body Weight–Based Dosing to a Flat Dose for Avelumab in Metastatic Merkel Cell and Advanced Urothelial Carcinoma Abstract Abstract Avelumab, an anti–programmed death‐ligand 1 monoclonal antibody approved for the treatment of metastatic Merkel cell carcinoma and platinum‐treated urothelial carcinoma, was initia... |
PMC4187956 | core_pubmed_pmc | Pharmacokinetic Interaction between Pyronaridine-Artesunate and Metoprolol | Pharmacokinetic Interaction between Pyronaridine-Artesunate and Metoprolol Abstract The objectives of this study were to characterize any drug-drug interaction between the antimalarial Pyramax (pyronaridine-artesunate [PA]) and the CYP2D6 probe substrate metoprolol and to assess the safety of 60-day or 90-day PA redosi... |
PMC12102056 | core_pubmed_pmc | Cannabidiol as an immune modulator: A comprehensive review | Cannabidiol as an immune modulator: A comprehensive review Abstract Cannabidiol (CBD), a non-psychoactive phytocannabinoid derived from Cannabis sativa , has emerged as a promising therapeutic agent due to its diverse pharmacological properties, including potent anti-inflammatory, neuroprotective, and immunomodulatory ... |
PMC6310898 | core_pubmed_pmc | Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities | Model‐Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities Abstract The development of model‐informed precision dosing ( MIPD ) tools, especially in the form of native or web‐based applications to be used at the bedside, has garnered marked attention in recent years. Their potential clinica... |
PMC5771594 | core_pubmed_pmc | Determination of 2,4-Dichlorophenoxyacetic acid (2,4-D) in rat serum for pharmacokinetic studies with a simple HPLC method | Determination of 2,4-Dichlorophenoxyacetic acid (2,4-D) in rat serum for pharmacokinetic studies with a simple HPLC method Abstract 2,4-Dichlorophenoxyacetic acid (2,4-D) is a chlorophenoxy herbicide used worldwide. We describe a high-performance liquid chromatography (HPLC) method with UV detection for the determinati... |
PMC10921645 | core_pubmed_pmc | Utility of sustainable ratio derivative spectrophotometry for the concurrent assay of synergistic repurposed drugs for COVID-19 infections; Insilico pharmacokinetics proof | Utility of sustainable ratio derivative spectrophotometry for the concurrent assay of synergistic repurposed drugs for COVID-19 infections; Insilico pharmacokinetics proof Abstract Abstract The cutting-edge combination of fluvoxamine (FVM) and ivermectin (IVM) has been presented as a proposed dosage form for the treatm... |
PMC12811167 | core_pubmed_pmc | In silico analysis of selected polyphenols as potential multitarget rheumatoid arthritis modifying agents | In silico analysis of selected polyphenols as potential multitarget rheumatoid arthritis modifying agents Abstract Introduction Rheumatoid arthritis (RA) arises from a complex inflammatory network involving cytokines, kinases, and matrix degrading enzymes. Methotrexate is the clinical standard but is limited by poor ph... |
PMC11246076 | core_pubmed_pmc | Impact of Obesity on Echinocandin Effectiveness in Treating Candida Infections: A Retrospective Observational Cohort Study | Impact of Obesity on Echinocandin Effectiveness in Treating Candida Infections: A Retrospective Observational Cohort Study Abstract Abstract Introduction Echinocandins are used to treat invasive candidiasis (IC), with FDA-approved doses indicated for both obese and non-obese patients. Pharmacokinetic (PK) studies have ... |
PMC11024016 | core_pubmed_pmc | Quantification of Unencapsulated Drug in Target Tissues Demonstrates Pharmacological Properties and Therapeutic Effects of Liposomal Topotecan (FF-10850) | Quantification of Unencapsulated Drug in Target Tissues Demonstrates Pharmacological Properties and Therapeutic Effects of Liposomal Topotecan (FF-10850) Abstract Purpose Quantifying unencapsulated drug concentrations in tissues is crucial for understanding the mechanisms underlying the efficacy and safety of liposomal... |
PMC6848909 | core_pubmed_pmc | A phase I pharmacokinetic study of belinostat in patients with advanced cancers and varying degrees of liver dysfunction | A phase I pharmacokinetic study of belinostat in patients with advanced cancers and varying degrees of liver dysfunction Abstract Aims The histone deacetylase inhibitor belinostat has activity in various cancers. Because belinostat is metabolized by the liver, reduced hepatic clearance could lead to excessive drug accu... |
PMC11653551 | core_pubmed_pmc | Replacing serum with dried blood microsampling for pharmacokinetics, viral neutralisation and immunogenicity bioanalysis supporting future paediatric development of RSM01, a candidate respiratory syncytial virus neutralising monoclonal antibody | Replacing serum with dried blood microsampling for pharmacokinetics, viral neutralisation and immunogenicity bioanalysis supporting future paediatric development of RSM01, a candidate respiratory syncytial virus neutralising monoclonal antibody Abstract Background Virus neutralising antibodies in serum are considered k... |
PMC3619084 | core_pubmed_pmc | A first-in-class, first-in-human, phase I trial of p28, a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in patients with advanced solid tumours | A first-in-class, first-in-human, phase I trial of p28, a non-HDM2-mediated peptide inhibitor of p53 ubiquitination in patients with advanced solid tumours Abstract Background: This first-in-human, phase I clinical trial of p28 (NSC745104), a 28-amino-acid fragment of the cupredoxin azurin, investigated the safety, tol... |
PMC11596597 | core_pubmed_pmc | Pseudomonas aeruginosa in the Frontline of the Greatest Challenge of Biofilm Infection—Its Tolerance to Antibiotics | Pseudomonas aeruginosa in the Frontline of the Greatest Challenge of Biofilm Infection—Its Tolerance to Antibiotics Abstract P. aeruginosa biofilms are aggregates of bacteria surrounded by a self-produced matrix which binds to some antibiotics such as aminoglycosides. P. aeruginosa biofilms are tolerant to antibiotics.... |
PMC7762806 | core_pubmed_pmc | Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype‐Derived Activity Scores | Examination of Metoprolol Pharmacokinetics and Pharmacodynamics Across CYP2D6 Genotype‐Derived Activity Scores Abstract Abstract Recent CYP2D6 phenotype standardization efforts by CYP2D6 activity score (AS) are based on limited pharmacokinetic (PK) and pharmacodynamic (PD) data. Using data from two independent clinical... |
PMC11930181 | core_pubmed_pmc | Bioequivalence Study of Ibuprofen and Diphenhydramine Hydrochloride mini liquid-filled capsules: A Size Reduction Alternative | Bioequivalence Study of Ibuprofen and Diphenhydramine Hydrochloride mini liquid-filled capsules: A Size Reduction Alternative Abstract Abstract Background Advil PM Liqui-Gels are widely used to improve the quality of life for individuals experiencing sleep disturbances due to pain. To accommodate those who have difficu... |
PMC5027105 | core_pubmed_pmc | Safety, efficacy and pharmacokinetic evaluations of a new coated chloroquine tablet in a single-arm open-label non-comparative trial in Brazil: a step towards a user-friendly malaria vivax treatment | Safety, efficacy and pharmacokinetic evaluations of a new coated chloroquine tablet in a single-arm open-label non-comparative trial in Brazil: a step towards a user-friendly malaria vivax treatment Abstract Abstract Background Malaria remains a major public health problem, with half the world population at risk of con... |
PMC5610674 | core_pubmed_pmc | Dose and Schedule Selection of the Oral Proteasome Inhibitor Ixazomib in Relapsed/Refractory Multiple Myeloma: Clinical and Model-Based Analyses | Dose and Schedule Selection of the Oral Proteasome Inhibitor Ixazomib in Relapsed/Refractory Multiple Myeloma: Clinical and Model-Based Analyses Abstract Background The oral proteasome inhibitor ixazomib has been approved by regulatory authorities around the world, including in the United States and the European Union,... |
PMC12275044 | core_pubmed_pmc | Pharmacokinetics of difloxacin in Sichuan Shelducks after single or multiple dosing | Pharmacokinetics of difloxacin in Sichuan Shelducks after single or multiple dosing Abstract Abstract This study evaluated both single and multiple dosing regimens of difloxacin administered via different routes to Sichuan Shelducks: single intramuscular ( sIM ), intravenous ( sIV ), oral gavage ( sPO ), and multiple i... |
PMC11679290 | core_pubmed_pmc | Rhein: An Updated Review Concerning Its Biological Activity, Pharmacokinetics, Structure Optimization, and Future Pharmaceutical Applications | Rhein: An Updated Review Concerning Its Biological Activity, Pharmacokinetics, Structure Optimization, and Future Pharmaceutical Applications Abstract Rhein is a natural active ingredient in traditional Chinese medicine that has attracted much attention due to its wide range of pharmacological activities. However, its ... |
PMC8359228 | core_pubmed_pmc | Biomarker‐Guided Individualization of Antibiotic Therapy | Biomarker‐Guided Individualization of Antibiotic Therapy Abstract Abstract Treatment failure of antibiotic therapy due to insufficient efficacy or occurrence of toxicity is a major clinical challenge, and is expected to become even more urgent with the global rise of antibiotic resistance. Strategies to optimize treatm... |
PMC5892780 | core_pubmed_pmc | Pharmacodynamic and pharmacokinetic effects and safety of verinurad in combination with febuxostat in adults with gout: a phase IIa, open-label study | Pharmacodynamic and pharmacokinetic effects and safety of verinurad in combination with febuxostat in adults with gout: a phase IIa, open-label study Abstract Objective Verinurad (RDEA3170) is a high-affinity, selective URAT1 inhibitor in development for treating gout and asymptomatic hyperuricaemia. This study evaluat... |
PMC10347378 | core_pubmed_pmc | Pharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge | Pharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge Abstract Abstract In the last 5 years, interest has grown in using phytocannabinoids, particularly cannabidiol (CBD), in veterinary medicine to treat several pathologies, including pain, epilepsy, anxiety, nausea, anorexia, sk... |
PMC7024191 | core_pubmed_pmc | A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine | A Liposomal Formulation for Improving Solubility and Oral Bioavailability of Nifedipine Abstract Abstract Proliposomes were used to improve the solubility and oral bioavailability of nifedipine. Nifedipine proliposomes were prepared by methanol injection-spray drying method. The response surface method was used to opti... |
PMC7499606 | core_pubmed_pmc | Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors | Phase I Trial of First-in-Class ATR Inhibitor M6620 (VX-970) as Monotherapy or in Combination With Carboplatin in Patients With Advanced Solid Tumors Abstract Abstract PURPOSE Preclinical studies demonstrated that ATR inhibition can exploit synthetic lethality (eg, in cancer cells with impaired compensatory DNA damage ... |
PMC4546108 | core_pubmed_pmc | Current and future antimicrobial treatment of gonorrhoea – the rapidly evolving Neisseria gonorrhoeae continues to challenge | Current and future antimicrobial treatment of gonorrhoea – the rapidly evolving Neisseria gonorrhoeae continues to challenge Abstract Abstract Neisseria gonorrhoeae has developed antimicrobial resistance (AMR) to all drugs previously and currently recommended for empirical monotherapy of gonorrhoea. In vitro resistance... |
PMC6205776 | core_pubmed_pmc | Complex interactions between malaria and malnutrition: a systematic literature review | Complex interactions between malaria and malnutrition: a systematic literature review Abstract Background Despite substantial improvement in the control of malaria and decreased prevalence of malnutrition over the past two decades, both conditions remain heavy burdens that cause hundreds of thousands of deaths in child... |
PMC10488663 | core_pubmed_pmc | Modified Rice Bran Arabinoxylan by Lentinus edodes Mycelial Enzyme as an Immunoceutical for Health and Aging—A Comprehensive Literature Review | Modified Rice Bran Arabinoxylan by Lentinus edodes Mycelial Enzyme as an Immunoceutical for Health and Aging—A Comprehensive Literature Review Abstract Abstract Rice bran arabinoxylan compound (RBAC) is derived from defatted rice bran enzymatically treated with Lentinus edodes mycelium. This review explores biologicall... |
PMC10054777 | core_pubmed_pmc | Nanosystems, Drug Molecule Functionalization and Intranasal Delivery: An Update on the Most Promising Strategies for Increasing the Therapeutic Efficacy of Antidepressant and Anxiolytic Drugs | Nanosystems, Drug Molecule Functionalization and Intranasal Delivery: An Update on the Most Promising Strategies for Increasing the Therapeutic Efficacy of Antidepressant and Anxiolytic Drugs Abstract Abstract Depression and anxiety are high incidence and debilitating psychiatric disorders, usually treated by antidepre... |
PMC12255705 | core_pubmed_pmc | Maximum likelihood inference for multivariate delay differential equation models | Maximum likelihood inference for multivariate delay differential equation models Abstract The maximum likelihood inference framework for delay differential equation models in the multivariate settings is developed. The number of delay parameters is assumed to be one or more. This study does not make any restrictive ass... |
PMC10433471 | core_pubmed_pmc | Physiologically Based Pharmacokinetic Model To Predict Metoprolol Disposition in Healthy and Disease Populations | Physiologically Based Pharmacokinetic Model To Predict Metoprolol Disposition in Healthy and Disease Populations Abstract The evolution in the development of drugs has increased the popularity of physiologically based pharmacokinetic (PBPK) models. This study seeks to assess the PK of metoprolol in populations with hea... |
PMC7329777 | core_pubmed_pmc | Systemic and Target-Site Pharmacokinetics of Antiparasitic Agents | Systemic and Target-Site Pharmacokinetics of Antiparasitic Agents Abstract Abstract About one-sixth of the world’s population is affected by a neglected tropical disease as defined by the World Health Organization and Center for Disease Control. Parasitic diseases comprise most of the neglected tropical disease list an... |
PMC10315697 | core_pubmed_pmc | Evaluation of 134 Ce/ 134 La as a PET Imaging Theranostic Pair for 225 Ac α-Radiotherapeutics | Evaluation of 134 Ce/ 134 La as a PET Imaging Theranostic Pair for 225 Ac α-Radiotherapeutics Abstract 225 Ac-targeted α-radiotherapy is a promising approach to treating malignancies, including prostate cancer. However, α-emitting isotopes are difficult to image because of low administered activities and a low fraction... |
PMC6199790 | core_pubmed_pmc | Variability of efavirenz plasma concentrations among pediatric HIV patients treated with efavirenz based combination antiretroviral therapy in Dar es Salaam, Tanzania | Variability of efavirenz plasma concentrations among pediatric HIV patients treated with efavirenz based combination antiretroviral therapy in Dar es Salaam, Tanzania Abstract Abstract Background Children are subject to varying drug pharmacokinetics which influence plasma drug levels, and hence treatment outcomes espec... |
PMC5501629 | core_pubmed_pmc | Insulin glargine 300 U/mL for basal insulin therapy in type 1 and type 2 diabetes mellitus | Insulin glargine 300 U/mL for basal insulin therapy in type 1 and type 2 diabetes mellitus Abstract Abstract Objective To review published clinical studies on the efficacy and safety of new insulin glargine 300 units/mL (Gla-300), a new long-acting insulin analog, for the treatment of type 1 and type 2 diabetes mellitu... |
PMC5074076 | core_pubmed_pmc | Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance | Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance Abstract Purpose Develop a minimal mechanistic model based on in vitro–in vivo extrapolation (IVIVE) principles to predict extent of passive tubular reabsorption. Assess the ability of the model de... |
PMC8163634 | core_pubmed_pmc | Development of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats | Development of UPLC-MS/MS Method for Studying the Pharmacokinetic Interaction Between Dasatinib and Posaconazole in Rats Abstract Abstract Background and Aim Dasatinib is approved for the treatment of leukaemia worldwide. Triazole agents such as posaconazole may be used for the control of secondary fungal infection wit... |
PMC5686279 | core_pubmed_pmc | PKPD modeling of acquired resistance to anti-cancer drug treatment | PKPD modeling of acquired resistance to anti-cancer drug treatment Abstract Abstract Non-small cell lung cancer (NSCLC) patients greatly benefit from the treatment with tyrosine kinase inhibitors (TKIs) targeting the epidermal growth factor receptor (EGFR). However, emergence of acquired resistance inevitable occurs af... |
PMC10864931 | core_pubmed_pmc | Adult and pediatric physiologically‐based biopharmaceutics modeling to explain lamotrigine immediate release absorption process | Adult and pediatric physiologically‐based biopharmaceutics modeling to explain lamotrigine immediate release absorption process Abstract Abstract Physiologically‐based biopharmaceutics modeling (PBBM) has potential to accelerate the development of new drug and formulations. An important application of PBBM is for speci... |
PMC11504384 | core_pubmed_pmc | Protective Effects of Anethole in Foeniculum vulgare Mill. Seed Ethanol Extract on Hypoxia/Reoxygenation Injury in H9C2 Heart Myoblast Cells | Protective Effects of Anethole in Foeniculum vulgare Mill. Seed Ethanol Extract on Hypoxia/Reoxygenation Injury in H9C2 Heart Myoblast Cells Abstract Abstract Background: Active compounds from plants and herbs are increasingly incorporated into modern medical systems to address cardiovascular diseases (CVDs). Foeniculu... |
PMC3403915 | core_pubmed_pmc | Efficacy of olanzapine long-acting injection in patients with acutely exacerbated schizophrenia: an insight from effect size comparison with historical oral data | Efficacy of olanzapine long-acting injection in patients with acutely exacerbated schizophrenia: an insight from effect size comparison with historical oral data Abstract Abstract Background To treat acute schizophrenia, a long-acting injectable antipsychotic needs a rapid onset of action and therapeutic profile simila... |
PMC10036133 | core_pubmed_pmc | Mechanistic Modeling of the Interplay Between Host Immune System, IL-7 and UCART19 Allogeneic CAR-T Cells in Adult B-cell Acute Lymphoblastic Leukemia | Mechanistic Modeling of the Interplay Between Host Immune System, IL-7 and UCART19 Allogeneic CAR-T Cells in Adult B-cell Acute Lymphoblastic Leukemia Abstract Abstract Chimeric antigen receptor (CAR)-T cell therapies have shown tremendous results against various hematologic cancers. Prior to cell infusion, a host prec... |
PMC9009980 | core_pubmed_pmc | A European cross-sectional survey to investigate how involved doctors training in clinical pharmacology are in drug concentration monitoring | A European cross-sectional survey to investigate how involved doctors training in clinical pharmacology are in drug concentration monitoring Abstract Purpose Therapeutic drug monitoring (TDM) is widely recognised as a key attribute of clinical pharmacologists; yet, the extent to which physicians undertaking postgraduat... |
PMC4410823 | core_pubmed_pmc | Preparation, characterization, and in vivo study of rhein-loaded poly(lactic- co -glycolic acid) nanoparticles for oral delivery | Preparation, characterization, and in vivo study of rhein-loaded poly(lactic- co -glycolic acid) nanoparticles for oral delivery Abstract A novel rhein formulation based on poly(lactic- co -glycolic acid) (PLGA) nanoparticles (NPs) suitable for oral administration was developed in this study. The designed nanosystems w... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.