id stringlengths 9 11 | source stringclasses 1
value | title stringlengths 15 560 | text stringlengths 2k 153k |
|---|---|---|---|
PMC11800098 | core_pubmed_pmc | Challenges and opportunities to address the emerging burden of targeted therapies in ovarian cancer | Challenges and opportunities to address the emerging burden of targeted therapies in ovarian cancer Abstract Highlights • Ovarian cancer management leads to significant patient out of pocket expenditure. • Patients may experience financial toxicity during the course of treatment. • Targeted therapies may increase treat... |
PMC11349847 | core_pubmed_pmc | A Novel Formulation of Ketorolac Tromethamine (NTM-001) in Continuous Infusion in Adults with and without Renal Impairment: A Randomized Controlled Pharmacologic Study | A Novel Formulation of Ketorolac Tromethamine (NTM-001) in Continuous Infusion in Adults with and without Renal Impairment: A Randomized Controlled Pharmacologic Study Abstract Abstract Introduction There is a medical need for a safe, effective nonopioid postoperative analgesic for older subjects, including those with ... |
PMC8613160 | core_pubmed_pmc | Population Cellular Kinetics of Lisocabtagene Maraleucel, an Autologous CD19-Directed Chimeric Antigen Receptor T-Cell Product, in Patients with Relapsed/Refractory Large B-Cell Lymphoma | Population Cellular Kinetics of Lisocabtagene Maraleucel, an Autologous CD19-Directed Chimeric Antigen Receptor T-Cell Product, in Patients with Relapsed/Refractory Large B-Cell Lymphoma Abstract Abstract Background and Objectives Lisocabtagene maraleucel (liso-cel) is a CD19-directed, defined composition, 4-1BB chimer... |
PMC4281073 | core_pubmed_pmc | Comparison of Drug Release and Pharmacokinetics after Transarterial Chemoembolization Using Diverse Lipiodol Emulsions and Drug-Eluting Beads | Comparison of Drug Release and Pharmacokinetics after Transarterial Chemoembolization Using Diverse Lipiodol Emulsions and Drug-Eluting Beads Abstract In many studies for chemoembolization of hepatocellular carcinoma, the Lipiodol emulsion preparation protocols, especially the mixing steps, were unclear or even unrevea... |
PMC6273216 | core_pubmed_pmc | Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and Development | Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and Development Abstract Dimethylarginine dimethylaminohydrolase (DDAH) is a highly conserved hydrolytic enzyme found in numerous species, including bacteria, rodents, and humans. In humans, the DDAH-1 isoform is kn... |
PMC6587326 | core_pubmed_pmc | Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet‐induced obesity | Delayed insulin absorption correlates with alterations in subcutaneous depot kinetics in rats with diet‐induced obesity Abstract Summary Objective Obesity is associated with delayed insulin absorption upon subcutaneous (s.c.) dosing in humans. The aim of this study was to investigate whether alterations in depot struct... |
PMC12110642 | core_pubmed_pmc | Drugs Used in “Chemsex”/Sexualized Drug Behaviour—Overview of the Related Clinical Psychopharmacological Issues | Drugs Used in “Chemsex”/Sexualized Drug Behaviour—Overview of the Related Clinical Psychopharmacological Issues Abstract Background : “Chemsex” involves the intake of a range of drugs (e.g., synthetic cathinones, gamma-hydroxybutyric acid/gamma-butyrolactone (GHB/GBL), ketamine, methamphetamine, “poppers”, type V phosp... |
PMC3197614 | core_pubmed_pmc | Drug Discovery for Duchenne Muscular Dystrophy via Utrophin Promoter Activation Screening | Drug Discovery for Duchenne Muscular Dystrophy via Utrophin Promoter Activation Screening Abstract Abstract Background Duchenne muscular dystrophy (DMD) is a devastating muscle wasting disease caused by mutations in dystrophin, a muscle cytoskeletal protein. Utrophin is a homologue of dystrophin that can functionally c... |
PMC4467261 | core_pubmed_pmc | Effects of Icosapent Ethyl (Eicosapentaenoic Acid Ethyl Ester) on Pharmacokinetic Parameters of Rosiglitazone in Healthy Subjects | Effects of Icosapent Ethyl (Eicosapentaenoic Acid Ethyl Ester) on Pharmacokinetic Parameters of Rosiglitazone in Healthy Subjects Abstract Background Icosapent ethyl is a high-purity form of eicosapentaenoic acid ethyl ester approved to reduce triglyceride levels in adults with triglycerides ≥500 mg/dL. Candidates for ... |
PMC12823317 | core_pubmed_pmc | Comparison of Metformin PBPK Models Incorporating Placental Transfer to Predict Fetal and Maternal Exposure | Comparison of Metformin PBPK Models Incorporating Placental Transfer to Predict Fetal and Maternal Exposure Abstract ABSTRACT Physiologically based pharmacokinetic (PBPK) modeling of placental drug transfer is an evolving tool for predicting fetal drug exposure. In this study, a pregnancy‐specific metformin PBPK model ... |
PMC12034913 | core_pubmed_pmc | Severe Impact of Omeprazole Timing on pH‐Sensitive Dasatinib Absorption: Unveiling Substantial Drug–Drug Interaction | Severe Impact of Omeprazole Timing on pH‐Sensitive Dasatinib Absorption: Unveiling Substantial Drug–Drug Interaction Abstract Abstract The absorption and bioavailability of most tyrosine kinase inhibitors are affected by gastrointestinal pH as they are weak basic lipophilic drugs. Hence, concomitant use of acid reducin... |
PMC9220178 | core_pubmed_pmc | Preclinical Characterization of Antioxidant Quinolyl Nitrone QN23 as a New Candidate for the Treatment of Ischemic Stroke | Preclinical Characterization of Antioxidant Quinolyl Nitrone QN23 as a New Candidate for the Treatment of Ischemic Stroke Abstract Abstract Nitrones are encouraging drug candidates for the treatment of oxidative stress-driven diseases such as acute ischemic stroke (AIS). In a previous study, we found a promising quinol... |
PMC3718992 | core_pubmed_pmc | A predictive pharmacokinetic–pharmacodynamic model of tumor growth kinetics in xenograft mice after administration of anticancer agents given in combination | A predictive pharmacokinetic–pharmacodynamic model of tumor growth kinetics in xenograft mice after administration of anticancer agents given in combination Abstract Abstract Purpose In clinical oncology, combination treatments are widely used and increasingly preferred over single drug administrations. A better charac... |
PMC11687222 | core_pubmed_pmc | Prediction and analysis of toxic and side effects of tigecycline based on deep learning | Prediction and analysis of toxic and side effects of tigecycline based on deep learning Abstract Abstract Background In recent years, with the increase of antibiotic resistance, tigecycline has attracted much attention as a new broad-spectrum glycylcycline antibiotic. It is widely used in the treatment of complex skin ... |
PMC5403958 | core_pubmed_pmc | From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine | From PK/PD to QSP: Understanding the Dynamic Effect of Cholesterol-Lowering Drugs on Atherosclerosis Progression and Stratified Medicine Abstract Current computational and mathematical tools are demonstrating the high value of using systems modeling approaches (e.g. Quantitative Systems Pharmacology) to understand the ... |
PMC11015073 | core_pubmed_pmc | Understanding CYP3A4 and P‐gp mediated drug–drug interactions through PBPK modeling – Case example of pralsetinib | Understanding CYP3A4 and P‐gp mediated drug–drug interactions through PBPK modeling – Case example of pralsetinib Abstract Abstract Pralsetinib, a potent and selective inhibitor of oncogenic RET fusion and RET mutant proteins, is a substrate of the drug metabolizing enzyme CYP3A4 and a substrate of the efflux transport... |
PMC8754504 | core_pubmed_pmc | Meropenem Target Attainment and Population Pharmacokinetics in Critically Ill Septic Patients with Preserved or Increased Renal Function | Meropenem Target Attainment and Population Pharmacokinetics in Critically Ill Septic Patients with Preserved or Increased Renal Function Abstract Abstract Purpose Critically ill patients with preserved or increased renal function have been shown to be at risk of underexposure to meropenem. Although many meropenem popul... |
PMC7531749 | core_pubmed_pmc | Evaluation of Renal Anionic Secretion Following Living-donor and Deceased-donor Renal Transplantation: A Clinical Pharmacokinetic Study of Cefoxitin Microdosing | Evaluation of Renal Anionic Secretion Following Living-donor and Deceased-donor Renal Transplantation: A Clinical Pharmacokinetic Study of Cefoxitin Microdosing Abstract Background. Renal transplantation is the treatment of choice for patients with end-stage renal disease. Because kidneys are the primary excretory orga... |
PMC11018886 | core_pubmed_pmc | Differential impact of fentanyl and morphine doses on ticagrelor-induced platelet inhibition in ST-segment elevation myocardial infarction: a subgroup analysis from the PERSEUS randomized trial | Differential impact of fentanyl and morphine doses on ticagrelor-induced platelet inhibition in ST-segment elevation myocardial infarction: a subgroup analysis from the PERSEUS randomized trial Abstract Abstract Introduction Among patients with ST-segment elevation myocardial infarction (STEMI) treated with primary per... |
PMC12755803 | core_pubmed_pmc | The Peak Plasma Concentration (Cmax)/Minimum Inhibitory Concentration (MIC) of bedaquiline and levofloxacin with special attention to the sputum conversion in the treatment of multidrug-resistant tuberculosis in Indonesia | The Peak Plasma Concentration (Cmax)/Minimum Inhibitory Concentration (MIC) of bedaquiline and levofloxacin with special attention to the sputum conversion in the treatment of multidrug-resistant tuberculosis in Indonesia Abstract Background Tuberculosis in Indonesia remains a serious public health concern, as the coun... |
PMC12635367 | core_pubmed_pmc | Pharmacological risks of khat–oral antidiabetic drug interactions among patients at Gondar university referral hospital | Pharmacological risks of khat–oral antidiabetic drug interactions among patients at Gondar university referral hospital Abstract Background Khat (Catha edulis), a psychoactive plant commonly chewed in Ethiopia, is known to influence drug metabolism through its active compound, cathinone. Among patients with T2DM, concu... |
PMC9051383 | core_pubmed_pmc | Human IgG1 Fc pH-dependent optimization from a constant pH molecular dynamics simulation analysis † | Human IgG1 Fc pH-dependent optimization from a constant pH molecular dynamics simulation analysis † Abstract The binding of IgG Fc with FcRn enables the long circulating half-life of IgG, where the Fc–FcRn complex interacts in a pH-dependent manner. This complex shows stronger interaction at pH ≤ 6.5 and weaker interac... |
PMC11408209 | core_pubmed_pmc | Insights from pharmacovigilance and pharmacodynamics on cardiovascular safety signals of NSAIDs | Insights from pharmacovigilance and pharmacodynamics on cardiovascular safety signals of NSAIDs Abstract Background and Aim Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat fever, pain, and inflammation. Concerns regarding their cardiovascular safety have been raised. However, the underlying me... |
PMC11068998 | core_pubmed_pmc | Metabolism and drug interactions of Korean ginseng based on the pharmacokinetic properties of ginsenosides: Current status and future perspectives | Metabolism and drug interactions of Korean ginseng based on the pharmacokinetic properties of ginsenosides: Current status and future perspectives Abstract Orally administered ginsenosides, the major active components of ginseng, have been shown to be biotransformed into a number of metabolites by gastric juice, digest... |
PMC10955127 | core_pubmed_pmc | Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure | Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure Abstract We performed an ab initio next-generation risk assessment (NGRA) for a fragrance ingredient, benzyl salicylate (BSal), to demonstrate how cosmetic ingredie... |
PMC6154636 | core_pubmed_pmc | Using UPLC-MS/MS for Characterization of Active Components in Extracts of Yupingfeng and Application to a Comparative Pharmacokinetic Study in Rat Plasma after Oral Administration | Using UPLC-MS/MS for Characterization of Active Components in Extracts of Yupingfeng and Application to a Comparative Pharmacokinetic Study in Rat Plasma after Oral Administration Abstract Yupingfeng (YPF), a famous traditional Chinese medicine, which contains a large array of compounds, has been effectually used in he... |
PMC10033663 | core_pubmed_pmc | Acute pharmacological profile of 2C-B-Fly-NBOMe in male Wistar rats—pharmacokinetics, effects on behaviour and thermoregulation | Acute pharmacological profile of 2C-B-Fly-NBOMe in male Wistar rats—pharmacokinetics, effects on behaviour and thermoregulation Abstract Introduction: N -2-methoxy-benzylated (“NBOMe”) analogues of phenethylamine are a group of new psychoactive substances (NPS) with reported strong psychedelic effects in sub-milligram ... |
PMC8184532 | core_pubmed_pmc | Population pharmacokinetic modelling to quantify the magnitude of drug-drug interactions between amlodipine and antiretroviral drugs | Population pharmacokinetic modelling to quantify the magnitude of drug-drug interactions between amlodipine and antiretroviral drugs Abstract Abstract Purpose Drug-drug interactions (DDIs) with antiretroviral drugs (ARVs) represent an important issue in elderly people living with HIV (PLWH). Amlodipine is a commonly pr... |
PMC8992239 | core_pubmed_pmc | Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection | Pharmacokinetics of ß-d-N4-Hydroxycytidine, the Parent Nucleoside of Prodrug Molnupiravir, in Nonplasma Compartments of Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection Abstract Abstract ß-d-N4-hydroxycytidine (NHC), the parent nucleoside of molnupiravir, a COVID-19 antiviral, was quantified at S... |
PMC3284992 | core_pubmed_pmc | Expression of recombinant human coagulation factors VII (rFVII) and IX (rFIX) in various cell types, glycosylation analysis, and pharmacokinetic comparison | Expression of recombinant human coagulation factors VII (rFVII) and IX (rFIX) in various cell types, glycosylation analysis, and pharmacokinetic comparison Conclusion Results and conclusions Identical protein structures and minor differences in post-translational modifications between rFVII from BHK, CHO, HEK293 cells,... |
PMC10321182 | core_pubmed_pmc | Chirality of antidepressive drugs: an overview of stereoselectivity | Chirality of antidepressive drugs: an overview of stereoselectivity Abstract Abstract Stereochemistry plays an important role in drug design because the enantiomers of a drug frequently vary in their biological action and pharmacokinetic profiles. Racemates of a drug with either an inactive or an unsafe enantiomer can ... |
PMC12823309 | core_pubmed_pmc | Generating Control Groups for Organ Impairment Studies: A Case‐Study Comparing Statistical and Population Pharmacokinetic‐Based Matching Approaches | Generating Control Groups for Organ Impairment Studies: A Case‐Study Comparing Statistical and Population Pharmacokinetic‐Based Matching Approaches Abstract ABSTRACT A common challenge in conducting phase 1 studies that assess the impact of organ impairment on the pharmacokinetics of a drug is the recruitment of a demo... |
PMC5009137 | core_pubmed_pmc | Comparable pharmacodynamics, efficacy, and safety of linagliptin 5 mg among Japanese, Asian and white patients with type 2 diabetes | Comparable pharmacodynamics, efficacy, and safety of linagliptin 5 mg among Japanese, Asian and white patients with type 2 diabetes Abstract Abstract Aims/Introduction The efficacy and safety of drugs can vary between different races or ethnic populations because of differences in the relationship of dose to exposure, ... |
PMC12346198 | core_pubmed_pmc | Valine–Niclosamide for Treatment of Androgen Receptor Splice Variant-Positive Hepatocellular Carcinoma | Valine–Niclosamide for Treatment of Androgen Receptor Splice Variant-Positive Hepatocellular Carcinoma Abstract Simple Summary Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and a leading cause of global cancer-related mortality. At present, the current front-line systemic therapies for advanced... |
PMC3263612 | core_pubmed_pmc | Development of an Oral Form of Azacytidine: 2′3′5′Triacetyl-5-Azacytidine | Development of an Oral Form of Azacytidine: 2′3′5′Triacetyl-5-Azacytidine Abstract Abstract Myelodysplastic syndromes (MDSs) represent a group of incurable stem-cell malignancies which are predominantly treated by supportive care. Epigenetic silencing through promoter methylation of a number of genes is present in poor... |
PMC6440611 | core_pubmed_pmc | Systemic pharmacokinetic/pharmacodynamic analysis of intravitreal aflibercept injection in patients with retinal diseases | Systemic pharmacokinetic/pharmacodynamic analysis of intravitreal aflibercept injection in patients with retinal diseases Abstract Objective Explore relationships between systemic exposure to intravitreal aflibercept injection (IAI) and systemic pharmacodynamic effects via post hoc analyses of clinical trials of IAI fo... |
PMC7977154 | core_pubmed_pmc | Eribulin, Child-Pugh score, and liver-function tests: lessons from pivotal breast cancer studies 301 and 305 | Eribulin, Child-Pugh score, and liver-function tests: lessons from pivotal breast cancer studies 301 and 305 Abstract Background The recommended starting dose of eribulin in patients with hepatic impairment is based on the Child-Pugh score, largely informed by a pharmacokinetic study of 18 patients. In the pivotal stud... |
PMC6058531 | core_pubmed_pmc | Inhalation delivery of topotecan is superior to intravenous exposure for suppressing lung cancer in a preclinical model | Inhalation delivery of topotecan is superior to intravenous exposure for suppressing lung cancer in a preclinical model Abstract Abstract Intravenous (IV) topotecan is approved for the treatment of various malignancies including lung cancer but its clinical use is greatly undermined by severe hematopoietic toxicity. We... |
PMC3849647 | core_pubmed_pmc | Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice | Pharmacokinetics and biodistribution of the cyclin-dependent kinase inhibitor -CR8- in mice Abstract Background CR8 is a second generation inhibitor of cyclin-dependent kinases derived from roscovitine. CR8 was shown to be 50–100 fold more potent than roscovitine in inducing apoptosis in different tumor cell lines. In ... |
PMC4444337 | core_pubmed_pmc | Antiviral Activity of TMC353121, a Respiratory Syncytial Virus (RSV) Fusion Inhibitor, in a Non-Human Primate Model | Antiviral Activity of TMC353121, a Respiratory Syncytial Virus (RSV) Fusion Inhibitor, in a Non-Human Primate Model Abstract Abstract Background The study assessed the antiviral activity of TMC353121, a respiratory syncytial virus (RSV) fusion inhibitor, in a preclinical non-human primate challenge model with a viral s... |
PMC4746214 | core_pubmed_pmc | Pharmacokinetic Bioequivalence, Safety, and Immunogenicity of DMB-3111, a Trastuzumab Biosimilar, and Trastuzumab in Healthy Japanese Adult Males: Results of a Randomized Trial | Pharmacokinetic Bioequivalence, Safety, and Immunogenicity of DMB-3111, a Trastuzumab Biosimilar, and Trastuzumab in Healthy Japanese Adult Males: Results of a Randomized Trial Abstract Background DMB-3111 is a biosimilar trastuzumab drug being jointly developed by Meiji Seika Pharma (Japan) and Dong-A Socio Holdings (... |
PMC11684502 | core_pubmed_pmc | Efficacy and safety of vancomycin compared with those of alternative treatments for methicillin‐resistant Staphylococcus aureus infections: An umbrella review | Efficacy and safety of vancomycin compared with those of alternative treatments for methicillin‐resistant Staphylococcus aureus infections: An umbrella review Abstract Abstract Objective To summarize the evidence on the efficacy and safety of vancomycin compared with those of alternative treatments in adult patients wi... |
PMC12006663 | core_pubmed_pmc | Subcutaneous Ocrelizumab in Patients With Multiple Sclerosis | Subcutaneous Ocrelizumab in Patients With Multiple Sclerosis Abstract Abstract Background and Objectives IV-administered ocrelizumab (OCR) is approved for the treatment of relapsing and primary progressive multiple sclerosis (RMS/PPMS). OCARINA II ( NCT05232825 ) was designed to demonstrate noninferiority in drug expos... |
PMC9293150 | core_pubmed_pmc | Phase 1/2a, open‐label, multicenter study of RM‐1929 photoimmunotherapy in patients with locoregional, recurrent head and neck squamous cell carcinoma | Phase 1/2a, open‐label, multicenter study of RM‐1929 photoimmunotherapy in patients with locoregional, recurrent head and neck squamous cell carcinoma Abstract Abstract Background Recurrent head and neck squamous cell carcinoma (rHNSCC) represents a significant global health burden with an unmet medical need. In this s... |
PMC9998565 | core_pubmed_pmc | Evaluation of the Influence of Sildenafil on the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Vericiguat in Healthy Adults | Evaluation of the Influence of Sildenafil on the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Vericiguat in Healthy Adults Abstract Background and Objective Vericiguat is approved for the treatment of patients with heart failure with ejection fraction < 45%. Sildenafil, indicated for the treatment of... |
PMC11143530 | core_pubmed_pmc | Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK‒STAT pathway | Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK‒STAT pathway Abstract Oncolytic viruses (OVs), a group of replication-competent viruses that can selectively infect and kill cancer cells while leaving healthy cells intact, are emerging as promising living anticancer agents. Unlike traditional drugs c... |
PMC11263918 | core_pubmed_pmc | Comparative study of the effects of antitussive drugs in a canine acute cough model | Comparative study of the effects of antitussive drugs in a canine acute cough model Abstract Abstract Background Cough is a common clinical complaint in small animal practice with limited treatment options for chronic underlying conditions. Objectives The present study aimed to evaluate the efficacy of three antitussiv... |
PMC12937467 | core_pubmed_pmc | TDM-Guided Dalbavancin Treatment for Complex Staphylococcus aureus Osteoarticular Infections in Children | TDM-Guided Dalbavancin Treatment for Complex Staphylococcus aureus Osteoarticular Infections in Children Abstract Abstract Background/Objectives : Dalbavancin is approved for pediatric acute bacterial skin and skin structure infections (ABSSSIs), yet real-world practice frequently necessitates off-label use for deep-se... |
PMC10015565 | core_pubmed_pmc | Influence of Murraya koenigii extract on diabetes induced rat brain aging | Influence of Murraya koenigii extract on diabetes induced rat brain aging Abstract Abstract Food supplements are used to improve cognitive functions in age-related dementia. This study was designed to determine the Murraya koenigii leaves’ effect on Alloxan-induced cognitive impairment in diabetic rats and the contents... |
PMC7306095 | core_pubmed_pmc | Allylmethylsulfide, a Sulfur Compound Derived from Garlic, Attenuates Isoproterenol-Induced Cardiac Hypertrophy in Rats | Allylmethylsulfide, a Sulfur Compound Derived from Garlic, Attenuates Isoproterenol-Induced Cardiac Hypertrophy in Rats Abstract Allylmethylsulfide (AMS) is a novel sulfur metabolite found in the garlic-fed serum of humans and animals. In the present study, we have observed that AMS is safe on chronic administration an... |
PMC10508491 | core_pubmed_pmc | A physiologically‐based pharmacokinetic model for tuberculosis drug disposition at extrapulmonary sites | A physiologically‐based pharmacokinetic model for tuberculosis drug disposition at extrapulmonary sites Abstract Abstract Tuberculosis (TB) is a leading cause of mortality attributed to an infectious agent. TB primarily targets the lungs, but in about 16% cases can affect other organs as well, giving rise to extrapulmo... |
PMC10996858 | core_pubmed_pmc | Pharmacokinetic of two oral doses of a 1:20 THC:CBD cannabis herbal extract in cats | Pharmacokinetic of two oral doses of a 1:20 THC:CBD cannabis herbal extract in cats Abstract Abstract Objective To determine the pharmacokinetics (PK) of two oral doses of a Cannabis herbal extract (CHE) containing 1:20 THC:CBD in 12 healthy Domestic Shorthair cats. Methods Single-dose PK were assessed after oral admin... |
PMC10443535 | core_pubmed_pmc | Pharmacokinetic Study of Enteric-Coated Sustained-Release Aspirin Tablets in Healthy Chinese Participants | Pharmacokinetic Study of Enteric-Coated Sustained-Release Aspirin Tablets in Healthy Chinese Participants Abstract Abstract Purpose To study and compare the pharmacokinetic characteristics of enteric-coated sustained-release (EcSr) aspirin tablets with enteric-coated (Ec) aspirin tablets (Bayer S.p.A) in healthy Chines... |
PMC9573392 | core_pubmed_pmc | From cis -Lobeline to trans -Lobeline: Study on the Pharmacodynamics and Isomerization Factors | From cis -Lobeline to trans -Lobeline: Study on the Pharmacodynamics and Isomerization Factors Abstract Abstract Lobeline is an alkaloid derived from the leaves of an Indian tobacco plant ( Lobelia inflata ), which has been prepared by chemical synthesis. It is classified as a partial nicotinic agonist and has a long h... |
PMC10750039 | core_pubmed_pmc | Clinical development of antivirals against SARS-CoV-2 and its variants | Clinical development of antivirals against SARS-CoV-2 and its variants Abstract Highlight • Developing antivirals is important for the treatment of coronavirus diseases, • Many viral factors and host factors serve as targets for developing antivirals, • Many repurposed antivirals did not demonstrate great efficacy in c... |
PMC10296334 | core_pubmed_pmc | Pharmacokinetics of Antibacterial Agents in the Elderly: The Body of Evidence | Pharmacokinetics of Antibacterial Agents in the Elderly: The Body of Evidence Abstract Abstract Infections are important factors contributing to the morbidity and mortality among elderly patients. High rates of consumption of antimicrobial agents by the elderly may result in increased risk of toxic reactions, deteriora... |
PMC9000669 | core_pubmed_pmc | Design, Synthesis, Pharmacodynamic and In Silico Pharmacokinetic Evaluation of Some Novel Biginelli-Derived Pyrimidines and Fused Pyrimidines as Calcium Channel Blockers | Design, Synthesis, Pharmacodynamic and In Silico Pharmacokinetic Evaluation of Some Novel Biginelli-Derived Pyrimidines and Fused Pyrimidines as Calcium Channel Blockers Abstract Some new pyrimidine derivatives comprising arylsulfonylhydrazino, ethoxycarbonylhydrazino, thiocarbamoylhydrazino and substituted hydrazone a... |
PMC2834613 | core_pubmed_pmc | Antenatal allopurinol for reduction of birth asphyxia induced brain damage (ALLO-Trial); a randomized double blind placebo controlled multicenter study | Antenatal allopurinol for reduction of birth asphyxia induced brain damage (ALLO-Trial); a randomized double blind placebo controlled multicenter study Abstract Background Hypoxic-ischaemic encephalopathy is associated with development of cerebral palsy and cognitive disability later in life and is therefore one of the... |
PMC7076672 | core_pubmed_pmc | Improving the Oral Bioavailability of an Anti-Glioma Prodrug CAT3 Using Novel Solid Lipid Nanoparticles Containing Oleic Acid-CAT3 Conjugates | Improving the Oral Bioavailability of an Anti-Glioma Prodrug CAT3 Using Novel Solid Lipid Nanoparticles Containing Oleic Acid-CAT3 Conjugates Abstract 13a-(S)-3-pivaloyloxyl-6,7-dimethoxyphenanthro(9,10-b)-indolizidine (CAT3) is a novel oral anti-glioma pro-drug with a potent anti-tumor effect against temozolomide-resi... |
PMC7144358 | core_pubmed_pmc | Determination of KD025 (SLx-2119), a Selective ROCK2 Inhibitor, in Rat Plasma by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and Its Pharmacokinetic Application | Determination of KD025 (SLx-2119), a Selective ROCK2 Inhibitor, in Rat Plasma by High-Performance Liquid Chromatography-Tandem Mass Spectrometry and Its Pharmacokinetic Application Abstract Abstract KD025 (SLx-2119), the first specific Rho-associated protein kinase 2 (ROCK2) inhibitor, is a potential new drug candidate... |
PMC3717159 | core_pubmed_pmc | LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models | LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models Abstract Summary The HGF/MET signaling pathway regulates a wide variety of normal cellular functions that can be subverted to support n... |
PMC7919379 | core_pubmed_pmc | Cytotoxicity Evaluation of Chloroquine and Hydroxychloroquine in Multiple Cell Lines and Tissues by Dynamic Imaging System and Physiologically Based Pharmacokinetic Model | Cytotoxicity Evaluation of Chloroquine and Hydroxychloroquine in Multiple Cell Lines and Tissues by Dynamic Imaging System and Physiologically Based Pharmacokinetic Model Abstract Abstract Chloroquine (CQ) and hydroxychloroquine (HCQ) have been challenged in treating COVID-19 patients and still under debate due to the ... |
PMC9050387 | core_pubmed_pmc | The development and validation of an HPLC-MS/MS method for the determination of eriocitrin in rat plasma and its application to a pharmacokinetic study | The development and validation of an HPLC-MS/MS method for the determination of eriocitrin in rat plasma and its application to a pharmacokinetic study Abstract Abstract Eriocitrin is one of the major active constituents of lemon fruit, and it possesses strong antioxidant, lipid-lowering, anticancer and anti-inflammato... |
PMC8739161 | core_pubmed_pmc | Safety, antitumor activity, and pharmacokinetics of dostarlimab, an anti-PD-1, in patients with advanced solid tumors: a dose–escalation phase 1 trial | Safety, antitumor activity, and pharmacokinetics of dostarlimab, an anti-PD-1, in patients with advanced solid tumors: a dose–escalation phase 1 trial Abstract Abstract Purpose New immuno-oncology therapies targeting programmed cell death receptor 1 (PD-1) have improved patient outcomes in a broad range of cancers. The... |
PMC8785535 | core_pubmed_pmc | Early vigabatrin augmenting GABA-ergic pathways in post-anoxic status epilepticus (VIGAB-STAT) phase IIa clinical trial study protocol | Early vigabatrin augmenting GABA-ergic pathways in post-anoxic status epilepticus (VIGAB-STAT) phase IIa clinical trial study protocol Abstract Abstract Background Nearly one in three unconscious cardiac arrest survivors experience post-anoxic status epilepticus (PASE). Historically, PASE has been deemed untreatable re... |
PMC9796721 | core_pubmed_pmc | Do we become better prescribers after graduation: A 1‐year international follow‐up study among junior doctors | Do we become better prescribers after graduation: A 1‐year international follow‐up study among junior doctors Abstract Aim The aim of this study was to investigate how the prescribing knowledge and skills of junior doctors in the Netherlands and Belgium develop in the year after graduation. We also analysed differences... |
PMC6628352 | core_pubmed_pmc | In Vivo Evaluation of Dual-Targeted Nanoparticles Encapsulating Paclitaxel and Everolimus | In Vivo Evaluation of Dual-Targeted Nanoparticles Encapsulating Paclitaxel and Everolimus Abstract A synergistic combination of paclitaxel (PTX) and everolimus (EVER) can allow for lower drug doses, reducing the toxicities associated with PTX, while maintaining therapeutic efficacy. Polymeric nanoparticles (NPs) of hig... |
PMC8139681 | core_pubmed_pmc | Phase I Trial on Arterial Embolization with Hypoxia Activated Tirapazamine for Unresectable Hepatocellular Carcinoma | Phase I Trial on Arterial Embolization with Hypoxia Activated Tirapazamine for Unresectable Hepatocellular Carcinoma Abstract Abstract Background Tirapazamine (TPZ) is a hypoxia activated drug that may be synergistic with transarterial embolization (TAE). The primary objective was to evaluate the safety of combining TP... |
PMC10398570 | core_pubmed_pmc | Physiologically-based pharmacokinetic modeling for single and multiple dosing regimens of ceftriaxone in healthy and chronic kidney disease populations: a tool for model-informed precision dosing | Physiologically-based pharmacokinetic modeling for single and multiple dosing regimens of ceftriaxone in healthy and chronic kidney disease populations: a tool for model-informed precision dosing Abstract Introduction: Ceftriaxone is one of commonly prescribed beta-lactam antibiotics with several label and off-label cl... |
PMC9306994 | core_pubmed_pmc | Assessment of Effects of Investigational TAK‐931, an Oral Cell Division Cycle 7 Kinase Inhibitor on the QTc Intervals in Patients With Advanced Solid Tumors | Assessment of Effects of Investigational TAK‐931, an Oral Cell Division Cycle 7 Kinase Inhibitor on the QTc Intervals in Patients With Advanced Solid Tumors Abstract Abstract TAK‐931, a novel, selective, small‐molecule inhibitor of cell division cycle 7 has been investigated in multiple clinical trials in patients with... |
PMC4819942 | core_pubmed_pmc | A phase I pharmacokinetics study comparing PF-06439535 (a potential biosimilar) with bevacizumab in healthy male volunteers | A phase I pharmacokinetics study comparing PF-06439535 (a potential biosimilar) with bevacizumab in healthy male volunteers Abstract Abstract Purpose This study compared the pharmacokinetics of PF-06439535, a potential bevacizumab biosimilar, to bevacizumab sourced from the European Union (bevacizumab-EU) and USA (beva... |
PMC12944511 | core_pubmed_pmc | Integrated Computational Investigation of Cannabis sativa Phytoconstituents as Putative Multi-Target Inhibitors in Skin Cancer: A Molecular Docking, Dynamics, and ADMET Profiling Study | Integrated Computational Investigation of Cannabis sativa Phytoconstituents as Putative Multi-Target Inhibitors in Skin Cancer: A Molecular Docking, Dynamics, and ADMET Profiling Study Abstract Abstract Background : Skin cancer progression is driven by the dysregulation of key oncogenic signaling pathways, including EG... |
PMC5659777 | core_pubmed_pmc | Clinical efficacy and pharmacokinetics of meloxicam in Mediterranean buffalo calves ( Bubalus bubalis ) | Clinical efficacy and pharmacokinetics of meloxicam in Mediterranean buffalo calves ( Bubalus bubalis ) Abstract Abstract The aims of the investigation were to establish for the first time (i) clinical efficacy and (ii) pharmacokinetic profile of meloxicam intravenously (IV) administered in male Mediterranean buffalo c... |
PMC7819284 | core_pubmed_pmc | PK/PD Study of Mycophenolate Mofetil in Children With Systemic Lupus Erythematosus to Inform Model-Based Precision Dosing | PK/PD Study of Mycophenolate Mofetil in Children With Systemic Lupus Erythematosus to Inform Model-Based Precision Dosing Abstract Objectives: To evaluate the mycophenolic acid [MPA, the active form of mycophenolate mofetil (MMF)] pharmacokinetic parameters in relation to clinical response to identify target exposure r... |
PMC6412495 | core_pubmed_pmc | Urine Caffeine Concentration in Doping Control Samples from 2004 to 2015 | Urine Caffeine Concentration in Doping Control Samples from 2004 to 2015 Abstract Abstract The ergogenic effect of caffeine is well-established, but the extent of its consumption in sport is unknown at the present. The use of caffeine was considered “prohibited” until 2004, but this stimulant was moved from the List of... |
PMC4300410 | core_pubmed_pmc | A randomised trial of the pharmacodynamic and pharmacokinetic effects of ticagrelor compared with clopidogrel in Hispanic patients with stable coronary artery disease | A randomised trial of the pharmacodynamic and pharmacokinetic effects of ticagrelor compared with clopidogrel in Hispanic patients with stable coronary artery disease Abstract Abstract The objective was to compare the pharmacodynamic (PD) and pharmacokinetic (PK) effects of ticagrelor with clopidogrel among subjects of... |
PMC3760091 | core_pubmed_pmc | Interaction of Carbamazepine with Herbs, Dietary Supplements, and Food: A Systematic Review | Interaction of Carbamazepine with Herbs, Dietary Supplements, and Food: A Systematic Review Abstract Abstract Background . Carbamazepine (CBZ) is a first-line antiepileptic drug which may be prone to drug interactions. Systematic review of herb- and food-drug interactions on CBZ is warranted to provide guidance for med... |
PMC7157624 | core_pubmed_pmc | Plasma Concentration Rise after the Intramuscular Administration of High Dose Medetomidine (0.13 mg/kg) for Semen Collection in Cats | Plasma Concentration Rise after the Intramuscular Administration of High Dose Medetomidine (0.13 mg/kg) for Semen Collection in Cats Abstract Abstract High dose medetomidine 0.13 mg/kg can be used for semen collection in cats with variable results in terms of quantity and quality. Therefore, a variation in terms of dis... |
PMC5161048 | core_pubmed_pmc | Role of cephalosporins in the era of Clostridium difficile infection | Role of cephalosporins in the era of Clostridium difficile infection Abstract Abstract The incidence of Clostridium difficile infection (CDI) in Europe has increased markedly since 2000. Previous meta-analyses have suggested a strong association between cephalosporin use and CDI, and many national programmes on CDI con... |
PMC8301571 | core_pubmed_pmc | Clinical pharmacology and dosing regimen optimization of neonatal opioid withdrawal syndrome treatments | Clinical pharmacology and dosing regimen optimization of neonatal opioid withdrawal syndrome treatments Abstract Abstract In this paper, we review the management of neonatal opioid withdrawal syndrome (NOWS) and clinical pharmacology of primary treatment agents in NOWS, including morphine, methadone, buprenorphine, clo... |
PMC9943892 | core_pubmed_pmc | Phase 1 Study of the Selective c-MET Inhibitor, HS-10241, in Patients With Advanced Solid Tumors | Phase 1 Study of the Selective c-MET Inhibitor, HS-10241, in Patients With Advanced Solid Tumors Abstract Abstract Introduction c-MET is an important therapeutic target for various cancers; however, the People’s Republic of China currently retails only one specific c-MET inhibitor. Our preclinical study has revealed th... |
PMC10620926 | core_pubmed_pmc | Development of a Method for Multisensory Stripping Voltammetry in the Analysis of Medical Preparations | Development of a Method for Multisensory Stripping Voltammetry in the Analysis of Medical Preparations Abstract For the effective dosage of newly developed ophthalmic drugs, an assessment of the dynamics of their concentration in lacrimal fluid over time is required. To express the detection and identification of drugs... |
PMC8461112 | core_pubmed_pmc | Efficacy predictors of omalizumab in Chinese patients with moderate-to-severe allergic asthma: Findings from a post-hoc analysis of a randomised phase III study ☆ | Efficacy predictors of omalizumab in Chinese patients with moderate-to-severe allergic asthma: Findings from a post-hoc analysis of a randomised phase III study ☆ Abstract Abstract Background Omalizumab has demonstrated efficacy as an add-on therapy in Chinese patients with moderate-to-severe allergic asthma. This post... |
PMC11678373 | core_pubmed_pmc | Pharmacokinetic Interaction Between Olaparib and Regorafenib in an Animal Model | Pharmacokinetic Interaction Between Olaparib and Regorafenib in an Animal Model Abstract Abstract Background: Olaparib (OLA) and regorafenib (REG) are metabolized by the CYP3A4 isoenzyme of cytochrome P450. Both drugs are also substrates and inhibitors of the membrane transporters P-glycoprotein and BCRP. Therefore, th... |
PMC5969050 | core_pubmed_pmc | Influence of aprepitant on the pharmacodynamics and pharmacokinetics of gliclazide in rats and rabbits | Influence of aprepitant on the pharmacodynamics and pharmacokinetics of gliclazide in rats and rabbits Abstract Abstract Background Concomitant drug administration is a general phenomenon in patients with chronic diseases such as diabetes mellitus. Among the currently available oral antidiabetic drugs, gliclazide is a ... |
PMC9199878 | core_pubmed_pmc | High intrapatient variability of tacrolimus exposure associated with poorer outcomes in liver transplantation | High intrapatient variability of tacrolimus exposure associated with poorer outcomes in liver transplantation Abstract Abstract Tacrolimus (TAC) is a dose‐dependent immunosuppressor with considerable intrapatient variability (IPV) in its pharmacokinetics. The aim of this work is to ascertain the association between TAC... |
PMC10456934 | core_pubmed_pmc | Deciphering Molecular Aspects of Potential α -Glucosidase Inhibitors within Aspergillus terreus : A Computational Odyssey of Molecular Docking-Coupled Dynamics Simulations and Pharmacokinetic Profiling | Deciphering Molecular Aspects of Potential α -Glucosidase Inhibitors within Aspergillus terreus : A Computational Odyssey of Molecular Docking-Coupled Dynamics Simulations and Pharmacokinetic Profiling Abstract Hyperglycemia, as a hallmark of the metabolic malady diabetes mellitus, has been an overwhelming healthcare b... |
PMC9781104 | core_pubmed_pmc | Prediction of Drug–Drug–Gene Interaction Scenarios of ( E )-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling | Prediction of Drug–Drug–Gene Interaction Scenarios of ( E )-Clomiphene and Its Metabolites Using Physiologically Based Pharmacokinetic Modeling Abstract Abstract Clomiphene, a selective estrogen receptor modulator (SERM), has been used for the treatment of anovulation for more than 50 years. However, since ( E )-clomip... |
PMC11505437 | core_pubmed_pmc | Ceftazidime–Avibactam Versus Polymyxin-Based Combination Therapies: A Study on 30-Day Mortality in Carbapenem-Resistant Enterobacterales Bloodstream Infections in an OXA-48-Endemic Region † | Ceftazidime–Avibactam Versus Polymyxin-Based Combination Therapies: A Study on 30-Day Mortality in Carbapenem-Resistant Enterobacterales Bloodstream Infections in an OXA-48-Endemic Region † Abstract Abstract Background : Ceftazidime–avibactam (CAZ-AVI) is recommended as first-line treatment for Oxacillinase-48 (OXA-48)... |
PMC12423363 | core_pubmed_pmc | Estimands for Early‐Phase Dose Optimization Trials in Oncology | Estimands for Early‐Phase Dose Optimization Trials in Oncology Abstract ABSTRACT Phase I dose escalation trials in oncology generally aim to find the maximum tolerated dose. However, with the advent of molecular‐targeted therapies and antibody drug conjugates, dose‐limiting toxicities are less frequently observed, givi... |
PMC11046337 | core_pubmed_pmc | Abatacept Pharmacokinetics and Exposure Response in Patients Hospitalized With COVID-19 | Abatacept Pharmacokinetics and Exposure Response in Patients Hospitalized With COVID-19 Abstract Key Points Question Is abatacept exposure associated with clinical outcomes in patients with severe COVID-19? Findings In this secondary analysis of abatacept pharmacokinetics and exposure-response data for 395 hospitalized... |
PMC8455721 | core_pubmed_pmc | Association of partial systemic exposure and abuse potential for opioid analgesics with abuse deterrence labeling claims supporting product-specific guidance | Association of partial systemic exposure and abuse potential for opioid analgesics with abuse deterrence labeling claims supporting product-specific guidance Abstract Background Over the past decade, U.S. FDA has approved 10 opioid analgesics in abuse-deterrent formulations (ADFs). ADFs are intended to reduce abuse of ... |
PMC6479889 | core_pubmed_pmc | Fritillariae Thunbergii Bulbus: Traditional Uses, Phytochemistry, Pharmacodynamics, Pharmacokinetics and Toxicity | Fritillariae Thunbergii Bulbus: Traditional Uses, Phytochemistry, Pharmacodynamics, Pharmacokinetics and Toxicity Abstract Abstract Fritillariae Thunbergii Bulbus (FTB) has been widely used as an antitussive herb for thousands of years in China. However, FTB’s traditional uses, chemical compounds and pharmacological ac... |
PMC11812503 | core_pubmed_pmc | Data-based regression models for predicting remifentanil pharmacokinetics | Data-based regression models for predicting remifentanil pharmacokinetics Abstract Background and Aims: Remifentanil is a powerful synthetic opioid drug with a short initiation and period of action, making it an ultra-short-acting opioid. It is delivered as an intravenous infusion during surgical procedures for pain ma... |
PMC7883216 | core_pubmed_pmc | Pharmacokinetics of exogenous GIP(1-42) in C57Bl/6 mice; Extremely rapid degradation but marked variation between available assays | Pharmacokinetics of exogenous GIP(1-42) in C57Bl/6 mice; Extremely rapid degradation but marked variation between available assays Abstract Highlights • Peptide hormone GIP shows an extremely short half-life of 90 s in mice. • Administration of GIP yields a very low ratio of intact:total peptide. • Co-administration wi... |
PMC11784458 | core_pubmed_pmc | Ex vivo assessment of sulbactam-durlobactam clearance during continuous renal replacement therapy to guide dosing recommendations | Ex vivo assessment of sulbactam-durlobactam clearance during continuous renal replacement therapy to guide dosing recommendations Abstract ABSTRACT Sulbactam-durlobactam is approved for the treatment of hospital-acquired and ventilator-associated bacterial pneumonia caused by susceptible isolates of Acinetobacter bauma... |
PMC7557909 | core_pubmed_pmc | Mitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson’s disease | Mitochondrial DNA damage as a potential biomarker of LRRK2 kinase activity in LRRK2 Parkinson’s disease Abstract Leucine-rich repeat kinase 2 (LRRK2) is a promising therapeutic target for the treatment of Parkinson’s disease (PD) and LRRK2 kinase inhibitors are currently being tested in early phase clinical trials. In ... |
PMC12160614 | core_pubmed_pmc | Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity Profiles of a Single‐Dose JYB1904 in Healthy Chinese Participants: A Phase Ia, Randomized, Double‐Blind, Placebo‐Controlled Study | Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity Profiles of a Single‐Dose JYB1904 in Healthy Chinese Participants: A Phase Ia, Randomized, Double‐Blind, Placebo‐Controlled Study Abstract ABSTRACT Allergic asthma, characterized by airborne allergen sensitivity and Th2 immune responses, is a ... |
PMC8437624 | core_pubmed_pmc | Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features | Aminoquinolines as Translational Models for Drug Repurposing: Anticancer Adjuvant Properties and Toxicokinetic-Related Features Abstract Abstract The indiscriminate consumption of antimalarials against coronavirus disease-2019 emphasizes the longstanding clinical weapons of medicines. In this work, we conducted a revie... |
PMC11912621 | core_pubmed_pmc | Comparative bioavailability study of two oral formulations of amoxicillin-clavulanic acid in healthy dogs | Comparative bioavailability study of two oral formulations of amoxicillin-clavulanic acid in healthy dogs Abstract Background Amoxicillin-clavulanic acid combination (AMX-CA) is a widely used oral antibiotic for companion animals. In Thailand, various AMX-CA formulations are available. This study aimed to evaluate and ... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.