row_id string | dataset_id string | source_dataset string | source_file string | source_table string | source_sha string | row_index int64 | split string | subject_type string | entry_id int64 | sequence_id int64 | target_sequence_id int64 | source_sequence_length int64 | target_sequence_length int64 | protein_id int64 | protein_name string | organism string | isoform int64 | protein_ids string | protein_names string | organisms string | isoforms string | uniprot_accessions string | interpro_accessions string | ec_numbers string | megascale_ids string | other_references string | mutations string | substitutions string | deletions string | insertions string | mutation_count int64 | substitution_count int64 | deletion_count int64 | insertion_count int64 | first_position int64 | first_source_aa string | first_target_aa string | conservation float64 | feature_types string | pdb_ids string | afdb_ids string | structure_ids string | structure_methods string | structure_resolution_min float64 | residue_positions string | residue_chain_names string | residue_secondary_structures string | residue_in_pocket_any bool | residue_in_tunnel_any bool | residue_asa_mean float64 | residue_bfactor_mean float64 | experiment_id int64 | experiment_dataset string | ph float64 | measure string | method string | buffer string | buffer_conc string | exp_temperature float64 | ion string | ion_conc string | pdb_chain_mutation string | tm float64 | dtm float64 | dg float64 | dg_text string | ddg float64 | dh float64 | dcp float64 | dhvh float64 | cm float64 | m_value float64 | trypsin_ml float64 | chymotrypsin_ml float64 | stabilizing float64 | stabilizing_text string | domainome_fitness float64 | domainome_fitness_std float64 | domainome_ddg float64 | domainome_ddg_std float64 | reversibility string | state string | measurement_types string | measurement_datasets string | annotation_types string | publication_id string | publication_type string | publication_title string | publication_year int64 | publication_doi string | publication_pmid string | publication_journal string | publication_url string | publication_author_count int64 | publication_authors string | annotations_json string | measurements_json string | features_json string |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
fireprotdb:8028 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,028 | train | sequence | 142 | 142 | -1 | 155 | -1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | 0 | 0 | 0 | 0 | -1 | null | null | false | false | null | null | 24,258 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 40.3 | null | null | null | 64.9 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":86209,"numValue":40.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":86210,"numValue":64.9,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":86211,"numValue":2.0,"references":[],"strValue":null,"type":"STATE"},{"datasets":[],"id":86212,"numValue":null,"references":[... | |||||||||||||||||||||||||
fireprotdb:8029 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,029 | train | sequence | 142 | 142 | -1 | 155 | -1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | 0 | 0 | 0 | 0 | -1 | null | null | false | false | null | null | 24,259 | ProTherm | 7.3 | fluorescence | Thermal | sodium phosphate | 25 mM | null | 39.8 | null | null | null | 66.2 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":86213,"numValue":39.8,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":86214,"numValue":66.2,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":86215,"numValue":2.0,"references":[],"strValue":null,"type":"STATE"},{"datasets":[],"id":86216,"numValue":null,"references":[... | |||||||||||||||||||||||||
fireprotdb:8030 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,030 | train | sequence | 142 | 142 | -1 | 155 | -1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | 0 | 0 | 0 | 0 | -1 | null | null | false | false | null | null | 24,260 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 40.7 | null | null | null | 67.7 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":86217,"numValue":40.7,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":86218,"numValue":67.7,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":86219,"numValue":2.0,"references":[],"strValue":null,"type":"STATE"},{"datasets":[],"id":86220,"numValue":null,"references":[... | |||||||||||||||||||||||||
fireprotdb:8031 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,031 | train | sequence | 142 | 142 | -1 | 155 | -1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | 0 | 0 | 0 | 0 | -1 | null | null | false | false | null | null | 24,261 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 54.1 | null | null | null | 67.6 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":86221,"numValue":54.1,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":86222,"numValue":67.6,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":86223,"numValue":2.0,"references":[],"strValue":null,"type":"STATE"},{"datasets":[],"id":86224,"numValue":null,"references":[... | |||||||||||||||||||||||||
fireprotdb:8032 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,032 | train | sequence | 142 | 142 | -1 | 155 | -1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | 0 | 0 | 0 | 0 | -1 | null | null | false | false | null | null | 25,933 | ProTherm | 6.6 | Fluorescence | GdnHCl | N-(2-acetamido)-iminodiacetic acid | 20 mM | 25 | NaCl | 100 mM | null | null | 5.04 | null | null | null | null | 1.11 | 4.52 | null | null | null | null | null | null | null | yes | DG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC | 615 | ARTICLE | Identification of a key structural element for protein folding within beta-hairpin turns. | 2,003 | 10.1016/s0022-2836(03)00321-8 | 12729767 | J Mol Biol;328;951-61 | 5 | Lee Jihun|Blaber Michael|Kim Jaewon|Brych Stephen R|Logan Timothy M | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"N-(2-acetamido)-iminodiacetic acid","type":"BUFFER"},{"numValue":null,"... | [{"datasets":[],"id":91157,"numValue":5.04,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":91158,"numValue":4.52,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":91159,"numValue":1.11,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":91160,"numValue":null,"references":[],"... | ||||||||||||||||||||||||
fireprotdb:8033 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,033 | train | sequence | 142 | 142 | -1 | 155 | -1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | 0 | 0 | 0 | 0 | -1 | null | null | false | false | null | null | 25,959 | ProTherm | 7.2 | Fluorescence | GdnHCl | Phosphate | 100 mM | 25 | null | null | 4.5 | null | null | null | null | 0.9 | 4.7 | null | null | null | null | null | null | null | Unknown | DG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC | 1831 | ARTICLE | Structurally homologous all beta-barrel proteins adopt different mechanisms of folding. | 2,003 | 10.1016/S0006-3495(03)74491-9 | 12829501 | Biophys J;85;459-72 | 8 | Srimathi Thiagarajan|Kumar Thallampuranam Krishnaswamy S|Kathir Karuppanan Muthusamy|Chi Ya-Hui|Srisailam Sampath|Lin Wann-Yin|Chiu Ing-Ming|Yu Chin | [{"numValue":7.2,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"100 mM","type"... | [{"datasets":[],"id":91240,"numValue":4.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":91241,"numValue":4.7,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":91242,"numValue":0.9,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":91243,"numValue":null,"references":[],"str... | ||||||||||||||||||||||||||
fireprotdb:8034 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,034 | train | sequence | 142 | 142 | -1 | 155 | -1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | 0 | 0 | 0 | 0 | -1 | null | null | false | false | null | null | 25,960 | ProTherm | 7.2 | CD | GdnHCl | Phosphate | 100 mM | 25 | null | null | 6.5 | null | null | null | null | 1.8 | 3.6 | null | null | null | null | null | null | null | Unknown | DG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC | 1831 | ARTICLE | Structurally homologous all beta-barrel proteins adopt different mechanisms of folding. | 2,003 | 10.1016/S0006-3495(03)74491-9 | 12829501 | Biophys J;85;459-72 | 8 | Srimathi Thiagarajan|Kumar Thallampuranam Krishnaswamy S|Kathir Karuppanan Muthusamy|Chi Ya-Hui|Srisailam Sampath|Lin Wann-Yin|Chiu Ing-Ming|Yu Chin | [{"numValue":7.2,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Phosphate","type":"BUFFER"},{"numValue":null,"strValue":"100 mM","type":"BUFFER_C... | [{"datasets":[],"id":91244,"numValue":6.5,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":91245,"numValue":3.6,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":91246,"numValue":1.8,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":91247,"numValue":null,"references":[],"str... | ||||||||||||||||||||||||||
fireprotdb:8035 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,035 | train | sequence | 142 | 142 | -1 | 155 | -1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | 0 | 0 | 0 | 0 | -1 | null | null | false | false | null | null | 26,659 | ProTherm | 8 | Fluorescence | GdnHCl | Sodium phosphate | 50mM | 25 | null | null | 6.11 | null | null | null | null | 1.23 | 4.97 | null | null | null | null | null | null | null | yes | 2.0 | DG|M|CM|STATE|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC | 1863 | ARTICLE | Mutation choice to eliminate buried free cysteines in protein therapeutics. | 2,015 | 10.1002/jps.24188 | 25312595 | J Pharm Sci;104;566-76 | 3 | Blaber Michael|Xia Xue|Longo Liam M | [{"numValue":8.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"50mM","... | [{"datasets":[],"id":93536,"numValue":6.11,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":93537,"numValue":4.97,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":93538,"numValue":1.23,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":93539,"numValue":2.0,"references":[],"s... | |||||||||||||||||||||||||
fireprotdb:8036 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,036 | train | sequence | 142 | 142 | -1 | 155 | -1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | 0 | 0 | 0 | 0 | -1 | null | null | false | false | null | null | 26,925 | ProTherm | 7.3 | Fluorescence | GdnHCl | H3PO4 | 25 mM | 20.15 | null | null | 5.53 | null | null | null | null | 1.13 | 4.87 | null | null | null | null | null | null | null | Yes | DG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":20.15,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":[],"id":94564,"numValue":5.53,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":94565,"numValue":4.87,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":94566,"numValue":1.13,"references":[],"strValue":null,"type":"CM"},{"datasets":[],"id":94567,"numValue":null,"references":[],"... | ||||||||||||||||||||||||||
fireprotdb:8037 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,037 | train | mutant | 7,982 | 142 | 8,706 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | K27V|C132V|P149V | K27V|C132V|P149V | 3 | 3 | 0 | 0 | 27 | K | V | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 27|132|149 | A | E|B | true | false | 42.264737 | 26.660595 | 17,109 | ProTherm | 8 | Fluorescence | GdnHCl | Sodium phosphate | 50mM | 25 | 1JQZ_A:K12V 1JQZ_A:C117V 1JQZ_A:P134V | null | null | 9.53 | -3.42 | null | null | null | 2.18 | 4.37 | null | null | null | null | null | null | null | yes | 2.0 | DG|DDG|M|CM|STATE|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 981 | ARTICLE | Time-averaged order parameter restraints in molecular dynamics simulations. | 2,014 | 10.1007/s10858-014-9866-7 | 25312596 | J Biomol NMR;60;169-87 | 3 | Hansen Niels|Heller Fabian|Schmid Nathan | [{"numValue":8.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"50mM","... | [{"datasets":[],"id":62987,"numValue":9.53,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":62988,"numValue":-3.42,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":62989,"numValue":4.37,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":62990,"numValue":2.18,"references":[]... | [{"id":8629,"numValue":7.0,"position":27,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8734,"numValue":4.0,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8751,"numValue":9.0,"position":149,"positionArray":null,"positionRange... | |||||||||||||
fireprotdb:8038 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,038 | train | mutant | 4,717 | 142 | 5,256 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | C31S | C31S | 1 | 1 | 0 | 0 | 31 | C | S | 8 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 31 | A | E | false | false | 0 | 18.865 | 11,126 | ProTherm | 6.6 | DSC | GdnHCl | GuHCl/ADA | 0.7 M | 25 | 2AFG_A:C16S | null | null | 2.08 | 2.89 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 395 | ARTICLE | Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life. | 2,000 | 10.1021/bi9927742 | 10852713 | Biochemistry;39;7153-8 | 4 | Blaber M|Khurana A|Culajay J F|Blaber S I | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"GuHCl/ADA","type":"BUFFER"},{"numValue":null,"strValue":"0.7 M","type":"BUFFER_C... | [{"datasets":[],"id":38287,"numValue":2.08,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":38288,"numValue":2.89,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":38289,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":8633,"numValue":8.0,"position":31,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8039 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,039 | train | mutant | 4,717 | 142 | 5,256 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | C31S | C31S | 1 | 1 | 0 | 0 | 31 | C | S | 8 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 31 | A | E | false | false | 0 | 18.865 | 12,477 | ProTherm | 8 | Fluorescence | GdnHCl | Sodium phosphate | 50mM | 25 | 1JQZ_A:C16S | null | null | 7.33 | -1.22 | null | null | null | 1.68 | 4.37 | null | null | null | null | null | null | null | yes | 2.0 | DG|DDG|M|CM|STATE|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 781 | ARTICLE | Accurate identification of neutralizing antibodies to adenovirus Ad36, -a putative contributor of obesity in humans. | 2,015 | 10.1016/j.jdiacomp.2014.09.004 | 25312598 | J Diabetes Complications;29;83-7 | 3 | Dubuisson Olga|Day Rena Sue|Dhurandhar Nikhil V | [{"numValue":8.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"50mM","... | [{"datasets":[],"id":45253,"numValue":7.33,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":45254,"numValue":-1.22,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":45255,"numValue":4.37,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":45256,"numValue":1.68,"references":[]... | [{"id":8633,"numValue":8.0,"position":31,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:8041 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,041 | train | mutant | 5,775 | 142 | 6,329 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | C31T | C31T | 1 | 1 | 0 | 0 | 31 | C | T | 8 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 31 | A | E | false | false | 0 | 18.865 | 12,478 | ProTherm | 8 | Fluorescence | GdnHCl | Sodium phosphate | 50mM | 25 | 1JQZ_A:C16T | null | null | 6.71 | -0.6 | null | null | null | 1.45 | 4.63 | null | null | null | null | null | null | null | yes | 2.0 | DG|DDG|M|CM|STATE|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 782 | ARTICLE | The alpha-lipoic acid decreases urinary podocalyxin excretion in type 2 diabetics by inhibiting oxidative stress in vivo. | 2,015 | 10.1016/j.jdiacomp.2014.09.011 | 25312599 | J Diabetes Complications;29;64-7 | 3 | Lin Haiyan|Ye Shandong|Xu Jiang | [{"numValue":8.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"50mM","... | [{"datasets":[],"id":45259,"numValue":6.71,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":45260,"numValue":-0.6,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":45261,"numValue":4.63,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":45262,"numValue":1.45,"references":[],... | [{"id":8633,"numValue":8.0,"position":31,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:8042 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,042 | train | mutant | 5,776 | 142 | 6,330 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | C31V | C31V | 1 | 1 | 0 | 0 | 31 | C | V | 8 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 31 | A | E | false | false | 0 | 18.865 | 12,479 | ProTherm | 8 | Fluorescence | GdnHCl | Sodium phosphate | 50mM | 25 | 1JQZ_A:C16V | null | null | 5.37 | 0.74 | null | null | null | 1.42 | 3.77 | null | null | null | null | null | null | null | yes | 2.0 | DG|DDG|M|CM|STATE|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 783 | ARTICLE | Electrical stimulation of the vagus nerve dermatome in the external ear is protective in rat cerebral ischemia. | 2,015 | 10.1016/j.brs.2014.09.009 | 25312600 | Brain Stimul;8;7-12 | 3 | Ay Ilknur|Napadow Vitaly|Ay Hakan | [{"numValue":8.0,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"Sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"50mM","... | [{"datasets":[],"id":45265,"numValue":5.37,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":45266,"numValue":0.74,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":45267,"numValue":3.77,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":45268,"numValue":1.42,"references":[],... | [{"id":8633,"numValue":8.0,"position":31,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:8043 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,043 | train | mutant | 6,957 | 142 | 7,608 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | C31S|H108G | C31S|H108G | 2 | 2 | 0 | 0 | 31 | C | S | 8 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 31|108 | A | E|S|T | false | false | 59.296249 | 19.5825 | 14,819 | ProTherm | 6.6 | DSC | Thermal | GuHCl/ADA | 0.7 M | null | 2AFG_A:C16S 2AFG_A:H93G | 33.05 | -6.4 | null | null | 40.61 | null | null | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 395 | ARTICLE | Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life. | 2,000 | 10.1021/bi9927742 | 10852713 | Biochemistry;39;7153-8 | 4 | Blaber M|Khurana A|Culajay J F|Blaber S I | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"GuHCl/ADA","type":"BUFFER"},{"numValue":null,"strValue":"0.7 M","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:C16S 2AFG_A:H93G... | [{"datasets":[],"id":54714,"numValue":33.05,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":54715,"numValue":-6.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":54716,"numValue":40.61,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":54717,"numValue":null,"references":... | [{"id":8633,"numValue":8.0,"position":31,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8044 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,044 | train | mutant | 6,957 | 142 | 7,608 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | C31S|H108G | C31S|H108G | 2 | 2 | 0 | 0 | 31 | C | S | 8 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 31|108 | A | E|S|T | false | false | 59.296249 | 19.5825 | 15,117 | ProTherm | 6.6 | DSC | Thermal | N-(2-acetamido)iminodiacetic acid (ADA) | 20 mM | 39.6 | NaCl | 0.1 M | 2AFG_A:C16S 2AFG_A:H93G | null | null | null | 0.84 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 395 | ARTICLE | Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life. | 2,000 | 10.1021/bi9927742 | 10852713 | Biochemistry;39;7153-8 | 4 | Blaber M|Khurana A|Culajay J F|Blaber S I | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":39.6,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"N-(2-acetamido)iminodiacetic acid (ADA)","type":"BUFFER"},{"numValue":null,"str... | [{"datasets":[],"id":55465,"numValue":0.84,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":55466,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":8633,"numValue":8.0,"position":31,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||
fireprotdb:8045 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,045 | train | mutant | 6,957 | 142 | 7,608 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | C31S|H108G | C31S|H108G | 2 | 2 | 0 | 0 | 31 | C | S | 8 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 31|108 | A | E|S|T | false | false | 59.296249 | 19.5825 | 15,410 | ProTherm | 6.6 | DSC | GdnHCl | GuHCl/ADA | 0.7 M | 25 | 2AFG_A:C16S 2AFG_A:H93G | null | null | 4.02 | 0.93 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DG|DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 395 | ARTICLE | Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life. | 2,000 | 10.1021/bi9927742 | 10852713 | Biochemistry;39;7153-8 | 4 | Blaber M|Khurana A|Culajay J F|Blaber S I | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"GuHCl/ADA","type":"BUFFER"},{"numValue":null,"strValue":"0.7 M","type":"BUFFER_C... | [{"datasets":[],"id":56569,"numValue":4.02,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":56570,"numValue":0.93,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":56571,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":8633,"numValue":8.0,"position":31,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8046 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,046 | train | mutant | 6,957 | 142 | 7,608 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | C31S|H108G | C31S|H108G | 2 | 2 | 0 | 0 | 31 | C | S | 8 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 31|108 | A | E|S|T | false | false | 59.296249 | 19.5825 | 15,412 | ProTherm | 6.6 | DSC | Thermal | GuHCl/ADA | 0.7 M | 25 | 2AFG_A:C16S 2AFG_A:H93G | null | null | null | 1.39 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 395 | ARTICLE | Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life. | 2,000 | 10.1021/bi9927742 | 10852713 | Biochemistry;39;7153-8 | 4 | Blaber M|Khurana A|Culajay J F|Blaber S I | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"GuHCl/ADA","type":"BUFFER"},{"numValue":null,"strValue":"0.7 M","type":"BUFFER_... | [{"datasets":[],"id":56574,"numValue":1.39,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":56575,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":8633,"numValue":8.0,"position":31,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8047 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,047 | train | mutant | 942 | 142 | 1,065 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y | H36Y | 1 | 1 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36 | A | E | false | false | 7.636028 | 21.122 | 1,701 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | null | 2AFG_A:H21Y | 43.4 | 3.6 | null | null | null | null | 69.3 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H21Y","type... | [{"datasets":[],"id":6352,"numValue":43.4,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":6353,"numValue":3.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":6354,"numValue":69.3,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":6355,"numValue":null,"references":[],"s... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8048 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,048 | train | mutant | 942 | 142 | 1,065 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y | H36Y | 1 | 1 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36 | A | E | false | false | 7.636028 | 21.122 | 1,706 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | null | 2AFG_A:H21Y | 42.5 | 1.8 | null | null | null | null | 67.2 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H21Y","type":"_PDB_CH... | [{"datasets":[],"id":6372,"numValue":42.5,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":6373,"numValue":1.8,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":6374,"numValue":67.2,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":6375,"numValue":null,"references":[],"s... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8049 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,049 | train | mutant | 942 | 142 | 1,065 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y | H36Y | 1 | 1 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36 | A | E | false | false | 7.636028 | 21.122 | 8,073 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | 40.7 | 2AFG_A:H21Y | null | null | null | -0.39 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | khan_protherm_data_mapped.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":40.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"... | [{"datasets":["khan_protherm_data_mapped.csv"],"id":27464,"numValue":-0.39,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27465,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:8050 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,050 | train | mutant | 942 | 142 | 1,065 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y | H36Y | 1 | 1 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36 | A | E | false | false | 7.636028 | 21.122 | 8,150 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | 39.8 | 2AFG_A:H21Y | null | null | null | -0.75 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":[],"id":27690,"numValue":-0.75,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27691,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8051 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,051 | train | mutant | 942 | 142 | 1,065 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y | H36Y | 1 | 1 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36 | A | E | false | false | 7.636028 | 21.122 | 12,705 | ProTherm | 7.3 | Fluorescence | GdnHCl | H3PO4 | 25 mM | 20.15 | 2AFG_A:H21Y | null | null | 6.54 | -1.01 | null | null | null | 1.36 | 4.8 | null | null | null | null | null | null | null | Yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":20.15,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":[],"id":46074,"numValue":6.54,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":46075,"numValue":-1.01,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46076,"numValue":4.8,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":46077,"numValue":1.36,"references":[],... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8052 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,052 | train | mutant | 7,417 | 142 | 8,100 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|L59F | H36Y|L59F | 2 | 2 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|59 | A | E | true | false | 3.818014 | 19.20475 | 15,816 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | null | 2AFG_A:H21Y 2AFG_A:L44F | 45 | 5.2 | null | null | null | null | 79.6 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H21Y 2AFG_A... | [{"datasets":[],"id":58091,"numValue":45.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58092,"numValue":5.2,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58093,"numValue":79.6,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58094,"numValue":null,"references":[... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8053 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,053 | train | mutant | 7,417 | 142 | 8,100 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|L59F | H36Y|L59F | 2 | 2 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|59 | A | E | true | false | 3.818014 | 19.20475 | 15,827 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | null | 2AFG_A:H21Y 2AFG_A:L44F | 44.9 | 4.2 | null | null | null | null | 64.3 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H21Y 2AFG_A:L44F","ty... | [{"datasets":[],"id":58135,"numValue":44.9,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58136,"numValue":4.2,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58137,"numValue":64.3,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58138,"numValue":null,"references":[... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8054 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,054 | train | mutant | 7,417 | 142 | 8,100 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|L59F | H36Y|L59F | 2 | 2 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|59 | A | E | true | false | 3.818014 | 19.20475 | 16,798 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | 40.7 | 2AFG_A:H21Y 2AFG_A:L44F | null | null | null | -0.89 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":40.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"... | [{"datasets":[],"id":61729,"numValue":-0.89,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61730,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8055 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,055 | train | mutant | 7,417 | 142 | 8,100 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|L59F | H36Y|L59F | 2 | 2 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|59 | A | E | true | false | 3.818014 | 19.20475 | 16,811 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | 39.8 | 2AFG_A:H21Y 2AFG_A:L44F | null | null | null | -1.09 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":[],"id":61756,"numValue":-1.09,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61757,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8056 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,056 | train | mutant | 7,418 | 142 | 8,101 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|H117Y | H36Y|H117Y | 2 | 2 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|117 | A | E|T | false | false | 9.158871 | 21.378 | 15,817 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | null | 2AFG_A:H21Y 2AFG_A:H102Y | 44.8 | 5 | null | null | null | null | 75.9 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H21Y 2AFG_A... | [{"datasets":[],"id":58095,"numValue":44.8,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58096,"numValue":5.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58097,"numValue":75.9,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58098,"numValue":null,"references":[... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8057 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,057 | train | mutant | 7,418 | 142 | 8,101 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|H117Y | H36Y|H117Y | 2 | 2 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|117 | A | E|T | false | false | 9.158871 | 21.378 | 15,828 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | null | 2AFG_A:H21Y 2AFG_A:H102Y | 42.7 | 2 | null | null | null | null | 60.2 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H21Y 2AFG_A:H102Y","t... | [{"datasets":[],"id":58139,"numValue":42.7,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58140,"numValue":2.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58141,"numValue":60.2,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58142,"numValue":null,"references":[... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8058 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,058 | train | mutant | 7,418 | 142 | 8,101 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|H117Y | H36Y|H117Y | 2 | 2 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|117 | A | E|T | false | false | 9.158871 | 21.378 | 16,812 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | 39.8 | 2AFG_A:H21Y 2AFG_A:H102Y | null | null | null | -1.05 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":[],"id":61758,"numValue":-1.05,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61759,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8059 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,059 | train | mutant | 7,418 | 142 | 8,101 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|H117Y | H36Y|H117Y | 2 | 2 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|117 | A | E|T | false | false | 9.158871 | 21.378 | 16,822 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | 39.8 | 2AFG_A:H21Y 2AFG_A:H102Y | null | null | null | -0.42 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"... | [{"datasets":[],"id":61778,"numValue":-0.42,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61779,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8060 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,060 | train | mutant | 7,419 | 142 | 8,102 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|F123Y | H36Y|F123Y | 2 | 2 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|123 | A | E|B | false | false | 6.816119 | 18.215318 | 15,818 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | null | 2AFG_A:H21Y 2AFG_A:F108Y | 43.7 | 3.9 | null | null | null | null | 82.2 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H21Y 2AFG_A... | [{"datasets":[],"id":58099,"numValue":43.7,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58100,"numValue":3.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58101,"numValue":82.2,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58102,"numValue":null,"references":[... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8061 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,061 | train | mutant | 7,419 | 142 | 8,102 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|F123Y | H36Y|F123Y | 2 | 2 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|123 | A | E|B | false | false | 6.816119 | 18.215318 | 15,829 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | null | 2AFG_A:H21Y 2AFG_A:F108Y | 43.6 | 2.9 | null | null | null | null | 66.8 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H21Y 2AFG_A:F108Y","t... | [{"datasets":[],"id":58143,"numValue":43.6,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58144,"numValue":2.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58145,"numValue":66.8,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58146,"numValue":null,"references":[... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8062 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,062 | train | mutant | 7,419 | 142 | 8,102 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|F123Y | H36Y|F123Y | 2 | 2 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|123 | A | E|B | false | false | 6.816119 | 18.215318 | 16,799 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | 40.7 | 2AFG_A:H21Y 2AFG_A:F108Y | null | null | null | -0.61 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":40.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"... | [{"datasets":[],"id":61731,"numValue":-0.61,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61732,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8063 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,063 | train | mutant | 7,419 | 142 | 8,102 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|F123Y | H36Y|F123Y | 2 | 2 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|123 | A | E|B | false | false | 6.816119 | 18.215318 | 16,813 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | 39.8 | 2AFG_A:H21Y 2AFG_A:F108Y | null | null | null | -0.82 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":[],"id":61760,"numValue":-0.82,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61761,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8064 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,064 | train | mutant | 7,423 | 142 | 8,106 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|L59F|H117Y | H36Y|L59F|H117Y | 3 | 3 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|59|117 | A | E|T | true | false | 6.105914 | 20.0145 | 15,822 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | null | 2AFG_A:H21Y 2AFG_A:L44F 2AFG_A:H102Y | 46.5 | 6.7 | null | null | null | null | 88.4 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H21Y 2AFG_A... | [{"datasets":[],"id":58115,"numValue":46.5,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58116,"numValue":6.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58117,"numValue":88.4,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58118,"numValue":null,"references":[... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8065 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,065 | train | mutant | 7,423 | 142 | 8,106 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|L59F|H117Y | H36Y|L59F|H117Y | 3 | 3 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|59|117 | A | E|T | true | false | 6.105914 | 20.0145 | 15,833 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | null | 2AFG_A:H21Y 2AFG_A:L44F 2AFG_A:H102Y | 45.3 | 4.6 | null | null | null | null | 64 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H21Y 2AFG_A:L44F 2AFG... | [{"datasets":[],"id":58159,"numValue":45.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58160,"numValue":4.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58161,"numValue":64.0,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58162,"numValue":null,"references":[... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8067 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,067 | train | mutant | 7,423 | 142 | 8,106 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|L59F|H117Y | H36Y|L59F|H117Y | 3 | 3 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|59|117 | A | E|T | true | false | 6.105914 | 20.0145 | 16,817 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | 39.8 | 2AFG_A:H21Y 2AFG_A:L44F 2AFG_A:H102Y | null | null | null | -1.41 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":[],"id":61768,"numValue":-1.41,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61769,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8069 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,069 | train | mutant | 7,424 | 142 | 8,107 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|L59F|F123Y | H36Y|L59F|F123Y | 3 | 3 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|59|123 | A | E|B | true | false | 4.544079 | 17.906045 | 15,834 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | null | 2AFG_A:H21Y 2AFG_A:L44F 2AFG_A:F108Y | 46.1 | 5.4 | null | null | null | null | 67.5 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H21Y 2AFG_A:L44F 2AFG... | [{"datasets":[],"id":58163,"numValue":46.1,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58164,"numValue":5.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58165,"numValue":67.5,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58166,"numValue":null,"references":[... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8070 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,070 | train | mutant | 7,424 | 142 | 8,107 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|L59F|F123Y | H36Y|L59F|F123Y | 3 | 3 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|59|123 | A | E|B | true | false | 4.544079 | 17.906045 | 16,804 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | 40.7 | 2AFG_A:H21Y 2AFG_A:L44F 2AFG_A:F108Y | null | null | null | -1.15 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":40.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"... | [{"datasets":[],"id":61741,"numValue":-1.15,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61742,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8071 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,071 | train | mutant | 7,424 | 142 | 8,107 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|L59F|F123Y | H36Y|L59F|F123Y | 3 | 3 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|59|123 | A | E|B | true | false | 4.544079 | 17.906045 | 16,818 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | 39.8 | 2AFG_A:H21Y 2AFG_A:L44F 2AFG_A:F108Y | null | null | null | -1.27 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":[],"id":61770,"numValue":-1.27,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61771,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8072 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,072 | train | mutant | 7,425 | 142 | 8,108 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|H117Y|F123Y | H36Y|H117Y|F123Y | 3 | 3 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|117|123 | A | E|T|B | false | false | 8.104651 | 19.354879 | 15,824 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | null | 2AFG_A:H21Y 2AFG_A:H102Y 2AFG_A:F108Y | 46.3 | 6.5 | null | null | null | null | 82.4 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H21Y 2AFG_A... | [{"datasets":[],"id":58123,"numValue":46.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58124,"numValue":6.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58125,"numValue":82.4,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58126,"numValue":null,"references":[... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange... | ||||||||||||||
fireprotdb:8073 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,073 | train | mutant | 7,425 | 142 | 8,108 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|H117Y|F123Y | H36Y|H117Y|F123Y | 3 | 3 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|117|123 | A | E|T|B | false | false | 8.104651 | 19.354879 | 15,835 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | null | 2AFG_A:H21Y 2AFG_A:H102Y 2AFG_A:F108Y | 44.5 | 3.8 | null | null | null | null | 72.2 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H21Y 2AFG_A:H102Y 2AF... | [{"datasets":[],"id":58167,"numValue":44.5,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58168,"numValue":3.8,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58169,"numValue":72.2,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58170,"numValue":null,"references":[... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange... | ||||||||||||||
fireprotdb:8074 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,074 | train | mutant | 7,425 | 142 | 8,108 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|H117Y|F123Y | H36Y|H117Y|F123Y | 3 | 3 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|117|123 | A | E|T|B | false | false | 8.104651 | 19.354879 | 16,805 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | 40.7 | 2AFG_A:H21Y 2AFG_A:H102Y 2AFG_A:F108Y | null | null | null | -0.81 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":40.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"... | [{"datasets":[],"id":61743,"numValue":-0.81,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61744,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange... | ||||||||||||||
fireprotdb:8075 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,075 | train | mutant | 7,425 | 142 | 8,108 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|H117Y|F123Y | H36Y|H117Y|F123Y | 3 | 3 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|117|123 | A | E|T|B | false | false | 8.104651 | 19.354879 | 16,819 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | 39.8 | 2AFG_A:H21Y 2AFG_A:H102Y 2AFG_A:F108Y | null | null | null | -1.36 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":[],"id":61772,"numValue":-1.36,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61773,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange... | ||||||||||||||
fireprotdb:8077 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,077 | train | mutant | 7,427 | 142 | 8,110 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|L59F|H117Y|F123Y | H36Y|L59F|H117Y|F123Y | 4 | 4 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|59|117|123 | A | E|T|B | true | false | 6.078488 | 18.838034 | 15,837 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | null | 2AFG_A:H21Y 2AFG_A:L44F 2AFG_A:H102Y 2AFG_A:F108Y | 46.7 | 6 | null | null | null | null | 65.2 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H21Y 2AFG_A:L44F 2AFG... | [{"datasets":[],"id":58175,"numValue":46.7,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58176,"numValue":6.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58177,"numValue":65.2,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58178,"numValue":null,"references":[... | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8078 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,078 | train | mutant | 7,427 | 142 | 8,110 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|L59F|H117Y|F123Y | H36Y|L59F|H117Y|F123Y | 4 | 4 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|59|117|123 | A | E|T|B | true | false | 6.078488 | 18.838034 | 16,807 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | 40.7 | 2AFG_A:H21Y 2AFG_A:L44F 2AFG_A:H102Y 2AFG_A:F108Y | null | null | null | -1.28 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":40.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"... | [{"datasets":[],"id":61747,"numValue":-1.28,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61748,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8079 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,079 | train | mutant | 7,427 | 142 | 8,110 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | H36Y|L59F|H117Y|F123Y | H36Y|L59F|H117Y|F123Y | 4 | 4 | 0 | 0 | 36 | H | Y | 5 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 36|59|117|123 | A | E|T|B | true | false | 6.078488 | 18.838034 | 16,821 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | 39.8 | 2AFG_A:H21Y 2AFG_A:L44F 2AFG_A:H102Y 2AFG_A:F108Y | null | null | null | -1.64 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":[],"id":61776,"numValue":-1.64,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61777,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8638,"numValue":5.0,"position":36,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8080 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,080 | train | mutant | 4,368 | 142 | 4,879 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | V46W | V46W | 1 | 1 | 0 | 0 | 46 | V | W | 8 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 46 | A | E | true | false | 11.714425 | 19.313572 | 10,329 | ProTherm | 6.6 | CD, Fluorescence | GdnHCl | ADA (N-(2-acetamide)iminodiaceticacid) | 25 | 2AFG_A:V31W | null | null | 4.49 | -0.96 | null | null | null | 0.91 | 4.95 | null | null | null | null | null | null | null | Yes (>80%) | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION | 235 | ARTICLE | The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1. | 2,009 | 10.1016/j.jmb.2009.08.026 | 19695265 | J Mol Biol;393;113-27 | 2 | Lee Jihun|Blaber Michael | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD, Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"ADA (N-(2-acetamide)iminodiaceticacid)","type":"BUFFER"},{"numValue... | [{"datasets":[],"id":35432,"numValue":4.49,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":35433,"numValue":-0.96,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":35434,"numValue":4.95,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":35435,"numValue":0.91,"references":[]... | [{"id":8648,"numValue":8.0,"position":46,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||||
fireprotdb:8081 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,081 | train | mutant | 7,662 | 142 | 8,365 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|K133E | Q55P|K133E | 2 | 2 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|133 | A | G|L|T | true | true | 57.731485 | 27.695 | 16,237 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 47.4 | -7.1 | null | null | 74.5 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59452,"numValue":47.4,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59453,"numValue":-7.1,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59454,"numValue":74.5,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59455,"numValue":2.0,"references":[],... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8082 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,082 | train | mutant | 7,662 | 142 | 8,365 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|K133E | Q55P|K133E | 2 | 2 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|133 | A | G|L|T | true | true | 57.731485 | 27.695 | 16,248 | ProTherm | 7.3 | fluorescence | Thermal | sodium phosphate | 25 mM | null | 46.2 | -6.4 | null | null | 72.5 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59507,"numValue":46.2,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59508,"numValue":-6.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59509,"numValue":72.5,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59510,"numValue":2.0,"references":[],... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8083 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,083 | train | mutant | 7,662 | 142 | 8,365 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|K133E | Q55P|K133E | 2 | 2 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|133 | A | G|L|T | true | true | 57.731485 | 27.695 | 16,259 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 48.8 | -8.1 | null | null | 72.2 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59562,"numValue":48.8,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59563,"numValue":-8.1,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59564,"numValue":72.2,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59565,"numValue":2.0,"references":[],... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8084 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,084 | train | mutant | 7,662 | 142 | 8,365 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|K133E | Q55P|K133E | 2 | 2 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|133 | A | G|L|T | true | true | 57.731485 | 27.695 | 16,270 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 45.9 | 8.2 | null | null | 64.1 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59617,"numValue":45.9,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59618,"numValue":8.2,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59619,"numValue":64.1,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59620,"numValue":2.0,"references":[],"... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8085 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,085 | train | mutant | 7,664 | 142 | 8,367 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K133E | Q55P|S62I|K133E | 3 | 3 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|133 | A | G|E|L|T | true | true | 52.39388 | 26.880833 | 16,239 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 55.2 | -14.9 | null | null | 90.1 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59462,"numValue":55.2,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59463,"numValue":-14.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59464,"numValue":90.1,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59465,"numValue":2.0,"references":[]... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8086 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,086 | train | mutant | 7,664 | 142 | 8,367 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K133E | Q55P|S62I|K133E | 3 | 3 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|133 | A | G|E|L|T | true | true | 52.39388 | 26.880833 | 16,250 | ProTherm | 7.3 | fluorescence | Thermal | sodium phosphate | 25 mM | null | 54.3 | -14.5 | null | null | 93.5 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59517,"numValue":54.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59518,"numValue":-14.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59519,"numValue":93.5,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59520,"numValue":2.0,"references":[]... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8087 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,087 | train | mutant | 7,664 | 142 | 8,367 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K133E | Q55P|S62I|K133E | 3 | 3 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|133 | A | G|E|L|T | true | true | 52.39388 | 26.880833 | 16,261 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 56.3 | -15.6 | null | null | 82.4 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59572,"numValue":56.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59573,"numValue":-15.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59574,"numValue":82.4,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59575,"numValue":2.0,"references":[]... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8088 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,088 | train | mutant | 7,664 | 142 | 8,367 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K133E | Q55P|S62I|K133E | 3 | 3 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|133 | A | G|E|L|T | true | true | 52.39388 | 26.880833 | 16,272 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 53.2 | 0.9 | null | null | 69.6 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59627,"numValue":53.2,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59628,"numValue":0.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59629,"numValue":69.6,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59630,"numValue":2.0,"references":[],"... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8089 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,089 | train | mutant | 7,665 | 142 | 8,368 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K133E|H108G | Q55P|S62I|K133E|H108G | 4 | 4 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|108|133 | A | G|E|S|L|T | true | true | 68.943535 | 25.235625 | 16,240 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 61.2 | -20.9 | null | null | 101.6 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59467,"numValue":61.2,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59468,"numValue":-20.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59469,"numValue":101.6,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59470,"numValue":2.0,"references":[... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8090 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,090 | train | mutant | 7,665 | 142 | 8,368 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K133E|H108G | Q55P|S62I|K133E|H108G | 4 | 4 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|108|133 | A | G|E|S|L|T | true | true | 68.943535 | 25.235625 | 16,251 | ProTherm | 7.3 | fluorescence | Thermal | sodium phosphate | 25 mM | null | 60.4 | -20.6 | null | null | 101.1 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59522,"numValue":60.4,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59523,"numValue":-20.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59524,"numValue":101.1,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59525,"numValue":2.0,"references":[... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8091 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,091 | train | mutant | 7,665 | 142 | 8,368 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K133E|H108G | Q55P|S62I|K133E|H108G | 4 | 4 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|108|133 | A | G|E|S|L|T | true | true | 68.943535 | 25.235625 | 16,262 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 61.7 | -21 | null | null | 83.4 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59577,"numValue":61.7,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59578,"numValue":-21.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59579,"numValue":83.4,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59580,"numValue":2.0,"references":[]... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8092 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,092 | train | mutant | 7,665 | 142 | 8,368 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K133E|H108G | Q55P|S62I|K133E|H108G | 4 | 4 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|108|133 | A | G|E|S|L|T | true | true | 68.943535 | 25.235625 | 16,273 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 59.2 | -5.1 | null | null | 75.5 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59632,"numValue":59.2,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59633,"numValue":-5.1,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59634,"numValue":75.5,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59635,"numValue":2.0,"references":[],... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8093 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,093 | train | mutant | 7,666 | 142 | 8,369 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K127N | Q55P|S62I|K127N | 3 | 3 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|127 | A | G|E|L|T | true | true | 66.876405 | 28.438796 | 16,241 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 58.5 | -18.2 | null | null | 108.5 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59472,"numValue":58.5,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59473,"numValue":-18.2,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59474,"numValue":108.5,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59475,"numValue":2.0,"references":[... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8094 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,094 | train | mutant | 7,666 | 142 | 8,369 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K127N | Q55P|S62I|K127N | 3 | 3 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|127 | A | G|E|L|T | true | true | 66.876405 | 28.438796 | 16,252 | ProTherm | 7.3 | fluorescence | Thermal | sodium phosphate | 25 mM | null | 56.6 | -16.8 | null | null | 107.2 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59527,"numValue":56.6,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59528,"numValue":-16.8,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59529,"numValue":107.2,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59530,"numValue":2.0,"references":[... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8095 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,095 | train | mutant | 7,666 | 142 | 8,369 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K127N | Q55P|S62I|K127N | 3 | 3 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|127 | A | G|E|L|T | true | true | 66.876405 | 28.438796 | 16,263 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 57 | -16.3 | null | null | 90 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59582,"numValue":57.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59583,"numValue":-16.3,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59584,"numValue":90.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59585,"numValue":2.0,"references":[]... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8097 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,097 | train | mutant | 7,667 | 142 | 8,370 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K127N|H108G | Q55P|S62I|K127N|H108G | 4 | 4 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|108|127 | A | G|E|S|L|T | true | true | 79.805428 | 26.404097 | 16,242 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 64.1 | -23.8 | null | null | 120.8 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59477,"numValue":64.1,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59478,"numValue":-23.8,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59479,"numValue":120.8,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59480,"numValue":2.0,"references":[... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8098 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,098 | train | mutant | 7,667 | 142 | 8,370 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K127N|H108G | Q55P|S62I|K127N|H108G | 4 | 4 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|108|127 | A | G|E|S|L|T | true | true | 79.805428 | 26.404097 | 16,253 | ProTherm | 7.3 | fluorescence | Thermal | sodium phosphate | 25 mM | null | 63.2 | -23.4 | null | null | 130.7 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59532,"numValue":63.2,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59533,"numValue":-23.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59534,"numValue":130.7,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59535,"numValue":2.0,"references":[... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8101 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,101 | train | mutant | 7,669 | 142 | 8,372 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|K127N|K133E | Q55P|K127N|K133E | 3 | 3 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|127|133 | A | G|L|T | true | true | 66.131883 | 27.48037 | 16,244 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 47 | -6.7 | null | null | 76.4 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59487,"numValue":47.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59488,"numValue":-6.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59489,"numValue":76.4,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59490,"numValue":2.0,"references":[],... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange... | ||||||||||||||
fireprotdb:8103 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,103 | train | mutant | 7,669 | 142 | 8,372 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|K127N|K133E | Q55P|K127N|K133E | 3 | 3 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|127|133 | A | G|L|T | true | true | 66.131883 | 27.48037 | 16,266 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 49 | -8.3 | null | null | 75 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59597,"numValue":49.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59598,"numValue":-8.3,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59599,"numValue":75.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59600,"numValue":2.0,"references":[],... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange... | ||||||||||||||
fireprotdb:8104 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,104 | train | mutant | 7,669 | 142 | 8,372 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|K127N|K133E | Q55P|K127N|K133E | 3 | 3 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|127|133 | A | G|L|T | true | true | 66.131883 | 27.48037 | 16,277 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 42.9 | 11.2 | null | null | 53 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59652,"numValue":42.9,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59653,"numValue":11.2,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59654,"numValue":53.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59655,"numValue":2.0,"references":[],... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange... | ||||||||||||||
fireprotdb:8105 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,105 | train | mutant | 7,671 | 142 | 8,374 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K127N|K133E | Q55P|S62I|K127N|K133E | 4 | 4 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|127|133 | A | G|E|L|T | true | true | 60.028581 | 26.923403 | 16,246 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 57 | -16.7 | null | null | 96.3 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59497,"numValue":57.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59498,"numValue":-16.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59499,"numValue":96.3,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59500,"numValue":2.0,"references":[]... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8106 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,106 | train | mutant | 7,671 | 142 | 8,374 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K127N|K133E | Q55P|S62I|K127N|K133E | 4 | 4 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|127|133 | A | G|E|L|T | true | true | 60.028581 | 26.923403 | 16,257 | ProTherm | 7.3 | fluorescence | Thermal | sodium phosphate | 25 mM | null | 55.9 | -16.1 | null | null | 100.6 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59552,"numValue":55.9,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59553,"numValue":-16.1,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59554,"numValue":100.6,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59555,"numValue":2.0,"references":[... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8107 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,107 | train | mutant | 7,671 | 142 | 8,374 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K127N|K133E | Q55P|S62I|K127N|K133E | 4 | 4 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|127|133 | A | G|E|L|T | true | true | 60.028581 | 26.923403 | 16,268 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 55.7 | -15 | null | null | 92 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59607,"numValue":55.7,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59608,"numValue":-15.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59609,"numValue":92.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59610,"numValue":2.0,"references":[]... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8108 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,108 | train | mutant | 7,671 | 142 | 8,374 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K127N|K133E | Q55P|S62I|K127N|K133E | 4 | 4 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|127|133 | A | G|E|L|T | true | true | 60.028581 | 26.923403 | 16,279 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 50.1 | 4 | null | null | 72 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59662,"numValue":50.1,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59663,"numValue":4.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59664,"numValue":72.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59665,"numValue":2.0,"references":[],"... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8109 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,109 | train | mutant | 7,672 | 142 | 8,375 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K127N|K133E|H108G | Q55P|S62I|K127N|K133E|H108G | 5 | 5 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|108|127|133 | A | G|E|S|L|T | true | true | 71.741364 | 25.598722 | 16,247 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 62.8 | -22.5 | null | null | 105.1 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59502,"numValue":62.8,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59503,"numValue":-22.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59504,"numValue":105.1,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59505,"numValue":2.0,"references":[... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8110 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,110 | train | mutant | 7,672 | 142 | 8,375 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K127N|K133E|H108G | Q55P|S62I|K127N|K133E|H108G | 5 | 5 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|108|127|133 | A | G|E|S|L|T | true | true | 71.741364 | 25.598722 | 16,258 | ProTherm | 7.3 | fluorescence | Thermal | sodium phosphate | 25 mM | null | 61.9 | -22.1 | null | null | 112.8 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59557,"numValue":61.9,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59558,"numValue":-22.1,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59559,"numValue":112.8,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59560,"numValue":2.0,"references":[... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8111 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,111 | train | mutant | 7,672 | 142 | 8,375 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K127N|K133E|H108G | Q55P|S62I|K127N|K133E|H108G | 5 | 5 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|108|127|133 | A | G|E|S|L|T | true | true | 71.741364 | 25.598722 | 16,269 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 63.2 | -22.5 | null | null | 102 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59612,"numValue":63.2,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59613,"numValue":-22.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59614,"numValue":102.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59615,"numValue":2.0,"references":[... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8112 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,112 | train | mutant | 7,672 | 142 | 8,375 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | Q55P|S62I|K127N|K133E|H108G | Q55P|S62I|K127N|K133E|H108G | 5 | 5 | 0 | 0 | 55 | Q | P | 1 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 55|62|108|127|133 | A | G|E|S|L|T | true | true | 71.741364 | 25.598722 | 16,280 | ProTherm | 7.3 | CD | Thermal | sodium phosphate | 25 mM | null | 58.8 | -4.7 | null | null | 81.6 | null | null | null | null | null | null | null | null | null | null | null | yes | 2.0 | TM|DTM|DH|STATE|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC | 430 | ARTICLE | Increased protein stability of FGF1 can compensate for its reduced affinity for heparin. | 2,009 | 10.1074/jbc.M109.001289 | 19574212 | J Biol Chem;284;25388-403 | 6 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}] | [{"datasets":[],"id":59667,"numValue":58.8,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59668,"numValue":-4.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59669,"numValue":81.6,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59670,"numValue":2.0,"references":[],... | [{"id":8657,"numValue":1.0,"position":55,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange"... | ||||||||||||||
fireprotdb:8113 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,113 | train | mutant | 126 | 142 | 143 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59P | L59P | 1 | 1 | 0 | 0 | 59 | L | P | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59 | A | E | true | false | 0 | 17.2875 | 238 | ProTherm | 6.6 | DSC | Thermal | N-(2-acetamido)iminodiacetic acid(ADA) | 20 mM | null | NaCl | 100 mM | 2AFG_A:L44P | 43.05 | 3 | null | null | 76.48 | null | 53.54 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|DHVH|REVERSIBILITY | AUTOMUTE_S1749.csv|Saraboji_S1791.csv | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 20 | ARTICLE | Stabilization of hen egg white lysozyme by a cavity-filling mutation. | 2,001 | 10.1110/ps.37401 | 11266617 | Protein Sci;10;313-20 | 5 | Ueda T|Imoto T|Ohmura T|Ootsuka K|Saito M | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"N-(2-acetamido)iminodiacetic acid(ADA)","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strVa... | [{"datasets":[],"id":977,"numValue":43.05,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":978,"numValue":3.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":979,"numValue":76.48,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":9... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:8114 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,114 | train | mutant | 126 | 142 | 143 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59P | L59P | 1 | 1 | 0 | 0 | 59 | L | P | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59 | A | E | true | false | 0 | 17.2875 | 8,081 | ProTherm | 6.6 | DSC | Thermal | N-(2-acetamido)iminodiacetic acid(ADA) | 20 mM | 40.2 | NaCl | 100 mM | 2AFG_A:L44P | null | null | null | -0.69 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 20 | ARTICLE | Stabilization of hen egg white lysozyme by a cavity-filling mutation. | 2,001 | 10.1110/ps.37401 | 11266617 | Protein Sci;10;313-20 | 5 | Ueda T|Imoto T|Ohmura T|Ootsuka K|Saito M | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":40.2,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"N-(2-acetamido)iminodiacetic acid(ADA)","type":"BUFFER"},{"numValue":null,"strV... | [{"datasets":["potapov_with_uniprot_mapping.csv"],"id":27480,"numValue":-0.69,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27481,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||
fireprotdb:8115 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,115 | train | mutant | 943 | 142 | 1,066 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F | L59F | 1 | 1 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59 | A | E | true | false | 0 | 17.2875 | 1,702 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | null | 2AFG_A:L44F | 41.3 | 1.5 | null | null | null | null | 70.8 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:L44F","type... | [{"datasets":[],"id":6356,"numValue":41.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":6357,"numValue":1.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":6358,"numValue":70.8,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":6359,"numValue":null,"references":[],"s... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8116 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,116 | train | mutant | 943 | 142 | 1,066 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F | L59F | 1 | 1 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59 | A | E | true | false | 0 | 17.2875 | 1,707 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | null | 2AFG_A:L44F | 42.9 | 2.2 | null | null | null | null | 70.5 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:L44F","type":"_PDB_CH... | [{"datasets":[],"id":6376,"numValue":42.9,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":6377,"numValue":2.2,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":6378,"numValue":70.5,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":6379,"numValue":null,"references":[],"s... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8117 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,117 | train | mutant | 943 | 142 | 1,066 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F | L59F | 1 | 1 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59 | A | E | true | false | 0 | 17.2875 | 2,657 | ProTherm | 6.6 | DSC | Thermal | ADA (N-(2-acetamide)iminodiaceticacid) | null | 2AFG_A:L44F | 42.85 | 3.1 | null | 0.72 | 78.15 | null | null | null | null | null | null | null | null | null | null | null | Yes (>80%) | TM|DTM|DH|DDG|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION | 235 | ARTICLE | The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1. | 2,009 | 10.1016/j.jmb.2009.08.026 | 19695265 | J Mol Biol;393;113-27 | 2 | Lee Jihun|Blaber Michael | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"ADA (N-(2-acetamide)iminodiaceticacid)","type":"BUFFER"},{"numValue":null,"strValue":"2AFG_A:L44F","type":"_PDB_CHAIN_MUTATION"}] | [{"datasets":[],"id":9739,"numValue":42.85,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":9740,"numValue":3.1,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":9741,"numValue":78.15,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":9742,"numValue":0.72,"references":[],"s... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||||
fireprotdb:8118 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,118 | train | mutant | 943 | 142 | 1,066 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F | L59F | 1 | 1 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59 | A | E | true | false | 0 | 17.2875 | 8,074 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | 40.7 | 2AFG_A:L44F | null | null | null | -0.47 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":40.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"... | [{"datasets":["potapov_with_uniprot_mapping.csv"],"id":27466,"numValue":-0.47,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27467,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:8119 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,119 | train | mutant | 943 | 142 | 1,066 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F | L59F | 1 | 1 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59 | A | E | true | false | 0 | 17.2875 | 8,151 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | 39.8 | 2AFG_A:L44F | null | null | null | -0.31 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":["khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27692,"numValue":-0.31,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27693,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||
fireprotdb:8120 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,120 | train | mutant | 943 | 142 | 1,066 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F | L59F | 1 | 1 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59 | A | E | true | false | 0 | 17.2875 | 12,706 | ProTherm | 7.3 | Fluorescence | GdnHCl | H3PO4 | 25 mM | 20.15 | 2AFG_A:L44F | null | null | 6.4 | -0.87 | null | null | null | 1.29 | 4.97 | null | null | null | null | null | null | null | Yes | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":20.15,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":[],"id":46079,"numValue":6.4,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":46080,"numValue":-0.87,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46081,"numValue":4.97,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":46082,"numValue":1.29,"references":[],... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8121 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,121 | train | mutant | 4,367 | 142 | 4,878 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59W | L59W | 1 | 1 | 0 | 0 | 59 | L | W | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59 | A | E | true | false | 0 | 17.2875 | 10,326 | ProTherm | 6.6 | CD, Fluorescence | GdnHCl | ADA (N-(2-acetamide)iminodiaceticacid) | 25 | 2AFG_A:L44W | null | null | 3.61 | -0.81 | null | null | null | 0.92 | 3.94 | null | null | null | null | null | null | null | Yes (>80%) | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION | 235 | ARTICLE | The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1. | 2,009 | 10.1016/j.jmb.2009.08.026 | 19695265 | J Mol Biol;393;113-27 | 2 | Lee Jihun|Blaber Michael | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD, Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"ADA (N-(2-acetamide)iminodiaceticacid)","type":"BUFFER"},{"numValue... | [{"datasets":[],"id":35417,"numValue":3.61,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":35418,"numValue":-0.81,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":35419,"numValue":3.94,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":35420,"numValue":0.92,"references":[]... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||||
fireprotdb:8122 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,122 | train | mutant | 4,367 | 142 | 4,878 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59W | L59W | 1 | 1 | 0 | 0 | 59 | L | W | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59 | A | E | true | false | 0 | 17.2875 | 10,331 | ProTherm | 6.6 | CD, Fluorescence | GdnHCl | ADA (N-(2-acetamide)iminodiaceticacid) | 25 | 2AFG_A:L44W | null | null | 6 | 0.57 | null | null | null | 1.23 | 4.88 | null | null | null | null | null | null | null | Yes (>80%) | DG|DDG|M|CM|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION | 235 | ARTICLE | The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1. | 2,009 | 10.1016/j.jmb.2009.08.026 | 19695265 | J Mol Biol;393;113-27 | 2 | Lee Jihun|Blaber Michael | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD, Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"ADA (N-(2-acetamide)iminodiaceticacid)","type":"BUFFER"},{"numValue... | [{"datasets":[],"id":35442,"numValue":6.0,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":35443,"numValue":0.57,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":35444,"numValue":4.88,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":35445,"numValue":1.23,"references":[],"... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | |||||||||||||||
fireprotdb:8123 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,123 | train | mutant | 7,297 | 142 | 7,967 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59P|L88V|V124L | L59P|L88V|V124L | 3 | 3 | 0 | 0 | 59 | L | P | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59|88|124 | A | E|L | true | false | 5.268561 | 16.012946 | 15,654 | ProTherm | 6.6 | DSC | Thermal | N-(2-acetamido)iminodiacetic acid(ADA) | 20 mM | null | NaCl | 100 mM | 2AFG_A:L44P 2AFG_A:L73V 2AFG_A:V109L | 39.35 | -0.7 | null | null | 61.42 | null | 30.71 | null | null | null | null | null | null | null | null | null | yes | TM|DTM|DH|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 20 | ARTICLE | Stabilization of hen egg white lysozyme by a cavity-filling mutation. | 2,001 | 10.1110/ps.37401 | 11266617 | Protein Sci;10;313-20 | 5 | Ueda T|Imoto T|Ohmura T|Ootsuka K|Saito M | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"N-(2-acetamido)iminodiacetic acid(ADA)","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strVa... | [{"datasets":[],"id":57450,"numValue":39.35,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":57451,"numValue":-0.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":57452,"numValue":61.42,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":57453,"numValue":30.71,"references"... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8690,"numValue":8.0,"position":88,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8726,"numValue":7.0,"position":124,"positionArray":null,"positionRange"... | ||||||||||||
fireprotdb:8124 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,124 | train | mutant | 7,297 | 142 | 7,967 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59P|L88V|V124L | L59P|L88V|V124L | 3 | 3 | 0 | 0 | 59 | L | P | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59|88|124 | A | E|L | true | false | 5.268561 | 16.012946 | 16,809 | ProTherm | 6.6 | DSC | Thermal | N-(2-acetamido)iminodiacetic acid(ADA) | 20 mM | 40.2 | NaCl | 100 mM | 2AFG_A:L44P 2AFG_A:L73V 2AFG_A:V109L | null | null | null | 0.14 | null | null | null | null | null | null | null | null | null | null | null | null | yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION | 20 | ARTICLE | Stabilization of hen egg white lysozyme by a cavity-filling mutation. | 2,001 | 10.1110/ps.37401 | 11266617 | Protein Sci;10;313-20 | 5 | Ueda T|Imoto T|Ohmura T|Ootsuka K|Saito M | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":40.2,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"N-(2-acetamido)iminodiacetic acid(ADA)","type":"BUFFER"},{"numValue":null,"strV... | [{"datasets":[],"id":61751,"numValue":0.14,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61752,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}] | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8690,"numValue":8.0,"position":88,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8726,"numValue":7.0,"position":124,"positionArray":null,"positionRange"... | ||||||||||||
fireprotdb:8125 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,125 | train | mutant | 7,420 | 142 | 8,103 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F|H117Y | L59F|H117Y | 2 | 2 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59|117 | A | E|T | true | false | 5.340857 | 19.46075 | 15,819 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | null | 2AFG_A:L44F 2AFG_A:H102Y | 43.4 | 3.6 | null | null | null | null | 83.3 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:L44F 2AFG_A... | [{"datasets":[],"id":58103,"numValue":43.4,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58104,"numValue":3.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58105,"numValue":83.3,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58106,"numValue":null,"references":[... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8126 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,126 | train | mutant | 7,420 | 142 | 8,103 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F|H117Y | L59F|H117Y | 2 | 2 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59|117 | A | E|T | true | false | 5.340857 | 19.46075 | 15,830 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | null | 2AFG_A:L44F 2AFG_A:H102Y | 43.6 | 2.9 | null | null | null | null | 65.6 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:L44F 2AFG_A:H102Y","t... | [{"datasets":[],"id":58147,"numValue":43.6,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58148,"numValue":2.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58149,"numValue":65.6,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58150,"numValue":null,"references":[... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8127 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,127 | train | mutant | 7,420 | 142 | 8,103 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F|H117Y | L59F|H117Y | 2 | 2 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59|117 | A | E|T | true | false | 5.340857 | 19.46075 | 16,800 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | 40.7 | 2AFG_A:L44F 2AFG_A:H102Y | null | null | null | -0.61 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":40.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"... | [{"datasets":[],"id":61733,"numValue":-0.61,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61734,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8129 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,129 | train | mutant | 7,421 | 142 | 8,104 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F|F123Y | L59F|F123Y | 2 | 2 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59|123 | A | E|B | true | false | 2.998105 | 16.298068 | 15,820 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | null | 2AFG_A:L44F 2AFG_A:F108Y | 42.6 | 2.8 | null | null | null | null | null | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:L44F 2AFG_A... | [{"datasets":[],"id":58107,"numValue":42.6,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58108,"numValue":2.8,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58109,"numValue":null,"references":[],"strValue":"84.2.","type":"DHVH"},{"datasets":[],"id":58110,"numValue":null,"references... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8130 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,130 | train | mutant | 7,421 | 142 | 8,104 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F|F123Y | L59F|F123Y | 2 | 2 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59|123 | A | E|B | true | false | 2.998105 | 16.298068 | 15,831 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | null | 2AFG_A:L44F 2AFG_A:F108Y | 44.3 | 3.6 | null | null | null | null | 73.8 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:L44F 2AFG_A:F108Y","t... | [{"datasets":[],"id":58151,"numValue":44.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58152,"numValue":3.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58153,"numValue":73.8,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58154,"numValue":null,"references":[... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8131 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,131 | train | mutant | 7,421 | 142 | 8,104 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F|F123Y | L59F|F123Y | 2 | 2 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59|123 | A | E|B | true | false | 2.998105 | 16.298068 | 16,801 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | 40.7 | 2AFG_A:L44F 2AFG_A:F108Y | null | null | null | -0.77 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":40.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"... | [{"datasets":[],"id":61735,"numValue":-0.77,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61736,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8132 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,132 | train | mutant | 7,421 | 142 | 8,104 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F|F123Y | L59F|F123Y | 2 | 2 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59|123 | A | E|B | true | false | 2.998105 | 16.298068 | 16,815 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | 39.8 | 2AFG_A:L44F 2AFG_A:F108Y | null | null | null | -0.58 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU... | [{"datasets":[],"id":61764,"numValue":-0.58,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61765,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] | ||||||||||||||
fireprotdb:8133 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,133 | train | mutant | 7,426 | 142 | 8,109 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F|H117Y|F123Y | L59F|H117Y|F123Y | 3 | 3 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59|117|123 | A | E|T|B | true | false | 5.559308 | 18.076712 | 15,825 | ProTherm | 7.3 | Fluorescence | Thermal | H3PO4 | 25 mM | null | 2AFG_A:L44F 2AFG_A:H102Y 2AFG_A:F108Y | 44.3 | 4.5 | null | null | null | null | 81.3 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:L44F 2AFG_A... | [{"datasets":[],"id":58127,"numValue":44.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58128,"numValue":4.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58129,"numValue":81.3,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58130,"numValue":null,"references":[... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange... | ||||||||||||||
fireprotdb:8134 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,134 | train | mutant | 7,426 | 142 | 8,109 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F|H117Y|F123Y | L59F|H117Y|F123Y | 3 | 3 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59|117|123 | A | E|T|B | true | false | 5.559308 | 18.076712 | 15,836 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | null | 2AFG_A:L44F 2AFG_A:H102Y 2AFG_A:F108Y | 45.2 | 4.5 | null | null | null | null | 62.3 | null | null | null | null | null | null | null | null | null | Yes | TM|DTM|DHVH|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:L44F 2AFG_A:H102Y 2AF... | [{"datasets":[],"id":58171,"numValue":45.2,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58172,"numValue":4.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58173,"numValue":62.3,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58174,"numValue":null,"references":[... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange... | ||||||||||||||
fireprotdb:8135 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,135 | train | mutant | 7,426 | 142 | 8,109 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F|H117Y|F123Y | L59F|H117Y|F123Y | 3 | 3 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59|117|123 | A | E|T|B | true | false | 5.559308 | 18.076712 | 16,806 | ProTherm | 7.3 | CD | Thermal | H3PO4 | 25 mM | 40.7 | 2AFG_A:L44F 2AFG_A:H102Y 2AFG_A:F108Y | null | null | null | -0.96 | null | null | null | null | null | null | null | null | null | null | null | null | Yes | DDG|REVERSIBILITY | PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION | 180 | ARTICLE | Design of fully active FGF-1 variants with increased stability. | 2,004 | 10.1093/protein/gzh076 | 15469994 | Protein Eng Des Sel;17;603-11 | 4 | Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni | [{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":40.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"... | [{"datasets":[],"id":61745,"numValue":-0.96,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61746,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}] | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange... | ||||||||||||||
fireprotdb:8137 | fireprotdb | LiteFold/FireProtDB | labeled/fireprotdb/fireprotdb_search_all.jsonl | tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl | 79354b4f8754e21c3eb41aaf3dd63ba34ae750cd | 8,137 | train | mutant | 7,532 | 142 | 8,233 | 155 | 155 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | 17 | Fibroblast growth factor 1 | Homo sapiens | 1 | P05230 | IPR002209|IPR008996 | L59F|F147W | L59F|F147W | 2 | 2 | 0 | 0 | 59 | L | F | 7 | CONSERVATION | 2AFG|1JQZ | 60|180 | null | 59|147 | A | E | true | false | 0.407819 | 14.976477 | 16,036 | ProTherm | 6.6 | DSC | Thermal | ADA (N-(2-acetamide)iminodiaceticacid) | null | 2AFG_A:L44F 2AFG_A:F132W | 43.85 | 4.1 | null | 0.98 | 78.87 | null | null | null | null | null | null | null | null | null | null | null | Yes (>80%) | TM|DTM|DH|DDG|REVERSIBILITY | PH|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION | 235 | ARTICLE | The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1. | 2,009 | 10.1016/j.jmb.2009.08.026 | 19695265 | J Mol Biol;393;113-27 | 2 | Lee Jihun|Blaber Michael | [{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"ADA (N-(2-acetamide)iminodiaceticacid)","type":"BUFFER"},{"numValue":null,"strValue":"2AFG_A:L44F 2AFG_A:F132W","type":"_PDB_CHAIN_MUTATIO... | [{"datasets":[],"id":58830,"numValue":43.85,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58831,"numValue":4.1,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58832,"numValue":78.87,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":58833,"numValue":0.98,"references":[... | [{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8749,"numValue":9.0,"position":147,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}] |
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