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string
dataset_id
string
source_dataset
string
source_file
string
source_table
string
source_sha
string
row_index
int64
split
string
subject_type
string
entry_id
int64
sequence_id
int64
target_sequence_id
int64
source_sequence_length
int64
target_sequence_length
int64
protein_id
int64
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string
organism
string
isoform
int64
protein_ids
string
protein_names
string
organisms
string
isoforms
string
uniprot_accessions
string
interpro_accessions
string
ec_numbers
string
megascale_ids
string
other_references
string
mutations
string
substitutions
string
deletions
string
insertions
string
mutation_count
int64
substitution_count
int64
deletion_count
int64
insertion_count
int64
first_position
int64
first_source_aa
string
first_target_aa
string
conservation
float64
feature_types
string
pdb_ids
string
afdb_ids
string
structure_ids
string
structure_methods
string
structure_resolution_min
float64
residue_positions
string
residue_chain_names
string
residue_secondary_structures
string
residue_in_pocket_any
bool
residue_in_tunnel_any
bool
residue_asa_mean
float64
residue_bfactor_mean
float64
experiment_id
int64
experiment_dataset
string
ph
float64
measure
string
method
string
buffer
string
buffer_conc
string
exp_temperature
float64
ion
string
ion_conc
string
pdb_chain_mutation
string
tm
float64
dtm
float64
dg
float64
dg_text
string
ddg
float64
dh
float64
dcp
float64
dhvh
float64
cm
float64
m_value
float64
trypsin_ml
float64
chymotrypsin_ml
float64
stabilizing
float64
stabilizing_text
string
domainome_fitness
float64
domainome_fitness_std
float64
domainome_ddg
float64
domainome_ddg_std
float64
reversibility
string
state
string
measurement_types
string
measurement_datasets
string
annotation_types
string
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string
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string
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string
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int64
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string
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string
publication_journal
string
publication_url
string
publication_author_count
int64
publication_authors
string
annotations_json
string
measurements_json
string
features_json
string
fireprotdb:8138
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,138
train
mutant
7,956
142
8,680
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
L59W|F147W
L59W|F147W
2
2
0
0
59
L
W
7
CONSERVATION
2AFG|1JQZ
60|180
null
59|147
A
E
true
false
0.407819
14.976477
17,004
ProTherm
6.6
CD, Fluorescence
GdnHCl
ADA (N-(2-acetamide)iminodiaceticacid)
25
2AFG_A:L44W 2AFG_A:F132W
null
null
5.74
0.93
null
null
null
1.32
4.33
null
null
null
null
null
null
null
Yes (>80%)
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION
235
ARTICLE
The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
2,009
10.1016/j.jmb.2009.08.026
19695265
J Mol Biol;393;113-27
2
Lee Jihun|Blaber Michael
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD, Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"ADA (N-(2-acetamide)iminodiaceticacid)","type":"BUFFER"},{"numValue...
[{"datasets":[],"id":62524,"numValue":5.74,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":62525,"numValue":0.93,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":62526,"numValue":4.33,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":62527,"numValue":1.32,"references":[],...
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fireprotdb:8139
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,139
train
mutant
7,958
142
8,682
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
L59F|C98T|C132V|F147W
L59F|C98T|C132V|F147W
4
4
0
0
59
L
F
7
CONSERVATION
2AFG|1JQZ
60|180
null
59|98|132|147
A
E|G|B
true
false
6.528509
16.75428
17,006
ProTherm
6.6
CD, Fluorescence
GdnHCl
ADA (N-(2-acetamide)iminodiaceticacid)
25
2AFG_A:L44F 2AFG_A:C83T 2AFG_A:C117V 2AFG_A:F132W
null
null
5.11
0.1
null
null
null
1.13
4.52
null
null
null
null
null
null
null
Yes (>80%)
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION
235
ARTICLE
The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
2,009
10.1016/j.jmb.2009.08.026
19695265
J Mol Biol;393;113-27
2
Lee Jihun|Blaber Michael
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[{"datasets":[],"id":62534,"numValue":5.11,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":62535,"numValue":0.1,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":62536,"numValue":4.52,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":62537,"numValue":1.13,"references":[],"...
[{"id":8661,"numValue":7.0,"position":59,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8700,"numValue":8.0,"position":98,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8734,"numValue":4.0,"position":132,"positionArray":null,"positionRange"...
fireprotdb:8140
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,140
train
mutant
7,663
142
8,366
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
S62I|K133E
S62I|K133E
2
2
0
0
62
S
I
6
CONSERVATION
2AFG|1JQZ
60|180
null
62|133
A
E|L
true
true
40.60189
23.814861
16,238
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
48.8
-8.5
null
null
75.1
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":59457,"numValue":48.8,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59458,"numValue":-8.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59459,"numValue":75.1,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59460,"numValue":2.0,"references":[],...
[{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8141
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,141
train
mutant
7,663
142
8,366
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
S62I|K133E
S62I|K133E
2
2
0
0
62
S
I
6
CONSERVATION
2AFG|1JQZ
60|180
null
62|133
A
E|L
true
true
40.60189
23.814861
16,249
ProTherm
7.3
fluorescence
Thermal
sodium phosphate
25 mM
null
47.6
-7.8
null
null
74
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":59512,"numValue":47.6,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59513,"numValue":-7.8,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59514,"numValue":74.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59515,"numValue":2.0,"references":[],...
[{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8142
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,142
train
mutant
7,663
142
8,366
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
S62I|K133E
S62I|K133E
2
2
0
0
62
S
I
6
CONSERVATION
2AFG|1JQZ
60|180
null
62|133
A
E|L
true
true
40.60189
23.814861
16,260
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
49.7
-9
null
null
81.4
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":59567,"numValue":49.7,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59568,"numValue":-9.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59569,"numValue":81.4,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59570,"numValue":2.0,"references":[],...
[{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8143
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,143
train
mutant
7,663
142
8,366
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
S62I|K133E
S62I|K133E
2
2
0
0
62
S
I
6
CONSERVATION
2AFG|1JQZ
60|180
null
62|133
A
E|L
true
true
40.60189
23.814861
16,271
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
46.7
7.4
null
null
75.8
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":59622,"numValue":46.7,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59623,"numValue":7.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59624,"numValue":75.8,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59625,"numValue":2.0,"references":[],"...
[{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8144
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,144
train
mutant
7,670
142
8,373
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
S62I|K127N|K133E
S62I|K127N|K133E
3
3
0
0
62
S
I
6
CONSERVATION
2AFG|1JQZ
60|180
null
62|127|133
A
E|L
true
true
54.712154
24.893611
16,245
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
48.5
-8.2
null
null
82.2
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":59492,"numValue":48.5,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59493,"numValue":-8.2,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59494,"numValue":82.2,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59495,"numValue":2.0,"references":[],...
[{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange...
fireprotdb:8145
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,145
train
mutant
7,670
142
8,373
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
S62I|K127N|K133E
S62I|K127N|K133E
3
3
0
0
62
S
I
6
CONSERVATION
2AFG|1JQZ
60|180
null
62|127|133
A
E|L
true
true
54.712154
24.893611
16,256
ProTherm
7.3
fluorescence
Thermal
sodium phosphate
25 mM
null
47.5
-7.7
null
null
83.3
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":59547,"numValue":47.5,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59548,"numValue":-7.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59549,"numValue":83.3,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59550,"numValue":2.0,"references":[],...
[{"id":8664,"numValue":6.0,"position":62,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange...
fireprotdb:8146
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,146
train
mutant
7,670
142
8,373
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
S62I|K127N|K133E
S62I|K127N|K133E
3
3
0
0
62
S
I
6
CONSERVATION
2AFG|1JQZ
60|180
null
62|127|133
A
E|L
true
true
54.712154
24.893611
16,267
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
49.3
-8.6
null
null
75.6
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
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fireprotdb:8147
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,147
train
mutant
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142
8,373
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
S62I|K127N|K133E
S62I|K127N|K133E
3
3
0
0
62
S
I
6
CONSERVATION
2AFG|1JQZ
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null
62|127|133
A
E|L
true
true
54.712154
24.893611
16,278
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
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43.3
10.8
null
null
57.6
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
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fireprotdb:8149
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,149
train
mutant
3,903
142
4,397
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
G77N
G77N
1
1
0
0
77
G
N
4
CONSERVATION
2AFG|1JQZ
60|180
null
77
A
L
true
false
29.46312
20.44375
9,056
ProTherm
6.6
Fluorescence
GdnHCl
N-(2-acetamido)-iminodiacetic acid
20 mM
25
NaCl
100 mM
2AFG_A:G62N
null
null
4.25
0.79
null
null
null
0.87
4.9
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
615
ARTICLE
Identification of a key structural element for protein folding within beta-hairpin turns.
2,003
10.1016/s0022-2836(03)00321-8
12729767
J Mol Biol;328;951-61
5
Lee Jihun|Blaber Michael|Kim Jaewon|Brych Stephen R|Logan Timothy M
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fireprotdb:8150
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,150
train
mutant
127
142
144
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
L88V
L88V
1
1
0
0
88
L
V
8
CONSERVATION
2AFG|1JQZ
60|180
null
88
A
E
true
false
13.319821
17.570625
239
ProTherm
6.6
DSC
Thermal
N-(2-acetamido)iminodiacetic acid(ADA)
20 mM
null
NaCl
100 mM
2AFG_A:L73V
31.55
-8.5
null
null
44.69
null
46.93
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DH|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
20
ARTICLE
Stabilization of hen egg white lysozyme by a cavity-filling mutation.
2,001
10.1110/ps.37401
11266617
Protein Sci;10;313-20
5
Ueda T|Imoto T|Ohmura T|Ootsuka K|Saito M
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fireprotdb:8151
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,151
train
mutant
127
142
144
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
L88V
L88V
1
1
0
0
88
L
V
8
CONSERVATION
2AFG|1JQZ
60|180
null
88
A
E
true
false
13.319821
17.570625
8,082
ProTherm
6.6
DSC
Thermal
N-(2-acetamido)iminodiacetic acid(ADA)
20 mM
40.2
NaCl
100 mM
2AFG_A:L73V
null
null
null
1.46
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
20
ARTICLE
Stabilization of hen egg white lysozyme by a cavity-filling mutation.
2,001
10.1110/ps.37401
11266617
Protein Sci;10;313-20
5
Ueda T|Imoto T|Ohmura T|Ootsuka K|Saito M
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":40.2,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"N-(2-acetamido)iminodiacetic acid(ADA)","type":"BUFFER"},{"numValue":null,"strV...
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fireprotdb:8152
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,152
train
mutant
7,296
142
7,966
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
L88V|V124L
L88V|V124L
2
2
0
0
88
L
V
8
CONSERVATION
2AFG|1JQZ
60|180
null
88|124
A
E|L
true
false
7.902842
15.37567
15,653
ProTherm
6.6
DSC
Thermal
N-(2-acetamido)iminodiacetic acid(ADA)
20 mM
null
NaCl
100 mM
2AFG_A:L73V 2AFG_A:V109L
35.45
-4.6
null
null
55.69
null
40.1
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DH|DHVH|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
20
ARTICLE
Stabilization of hen egg white lysozyme by a cavity-filling mutation.
2,001
10.1110/ps.37401
11266617
Protein Sci;10;313-20
5
Ueda T|Imoto T|Ohmura T|Ootsuka K|Saito M
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fireprotdb:8153
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,153
train
mutant
7,296
142
7,966
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
L88V|V124L
L88V|V124L
2
2
0
0
88
L
V
8
CONSERVATION
2AFG|1JQZ
60|180
null
88|124
A
E|L
true
false
7.902842
15.37567
16,808
ProTherm
6.6
DSC
Thermal
N-(2-acetamido)iminodiacetic acid(ADA)
20 mM
40.2
NaCl
100 mM
2AFG_A:L73V 2AFG_A:V109L
null
null
null
0.88
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
20
ARTICLE
Stabilization of hen egg white lysozyme by a cavity-filling mutation.
2,001
10.1110/ps.37401
11266617
Protein Sci;10;313-20
5
Ueda T|Imoto T|Ohmura T|Ootsuka K|Saito M
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":40.2,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"N-(2-acetamido)iminodiacetic acid(ADA)","type":"BUFFER"},{"numValue":null,"strV...
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fireprotdb:8154
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,154
train
mutant
2,129
142
2,414
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C98S
C98S
1
1
0
0
98
C
S
8
CONSERVATION
2AFG|1JQZ
60|180
null
98
A
G
false
false
0.134371
13.601667
4,196
ProTherm
6.6
DSC
Thermal
GuHCl/ADA
0.7 M
null
2AFG_A:C83S
26.45
-13
null
null
32.86
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DH|REVERSIBILITY
AUTOMUTE_S1749.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
395
ARTICLE
Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life.
2,000
10.1021/bi9927742
10852713
Biochemistry;39;7153-8
4
Blaber M|Khurana A|Culajay J F|Blaber S I
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fireprotdb:8155
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,155
train
mutant
2,129
142
2,414
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C98S
C98S
1
1
0
0
98
C
S
8
CONSERVATION
2AFG|1JQZ
60|180
null
98
A
G
false
false
0.134371
13.601667
11,124
ProTherm
6.6
DSC
GdnHCl
GuHCl/ADA
0.7 M
25
2AFG_A:C83S
null
null
3.63
1.31
null
null
null
null
null
null
null
null
null
null
null
null
yes
DG|DDG|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
395
ARTICLE
Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life.
2,000
10.1021/bi9927742
10852713
Biochemistry;39;7153-8
4
Blaber M|Khurana A|Culajay J F|Blaber S I
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"GuHCl/ADA","type":"BUFFER"},{"numValue":null,"strValue":"0.7 M","type":"BUFFER_C...
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fireprotdb:8156
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,156
train
mutant
2,129
142
2,414
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C98S
C98S
1
1
0
0
98
C
S
8
CONSERVATION
2AFG|1JQZ
60|180
null
98
A
G
false
false
0.134371
13.601667
11,128
ProTherm
6.6
DSC
Thermal
GuHCl/ADA
0.7 M
25
2AFG_A:C83S
null
null
null
1.91
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
395
ARTICLE
Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life.
2,000
10.1021/bi9927742
10852713
Biochemistry;39;7153-8
4
Blaber M|Khurana A|Culajay J F|Blaber S I
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fireprotdb:8157
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,157
train
mutant
2,129
142
2,414
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C98S
C98S
1
1
0
0
98
C
S
8
CONSERVATION
2AFG|1JQZ
60|180
null
98
A
G
false
false
0.134371
13.601667
12,481
ProTherm
8
Fluorescence
GdnHCl
Sodium phosphate
50mM
25
1JQZ_A:C83S
null
null
4.78
1.33
null
null
null
0.96
4.99
null
null
null
null
null
null
null
yes
2.0
DG|DDG|M|CM|STATE|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
785
ARTICLE
A chromophore-containing agglutinin from Haliclona manglaris: purification and biochemical characterization.
2,015
10.1016/j.ijbiomac.2014.10.003
25312602
Int J Biol Macromol;72;1368-75
3
Carneiro R?mulo Farias|de Almeida Alexandra Sampaio|de Melo Arthur Alves
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fireprotdb:8158
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
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train
mutant
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142
6,331
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C98A
C98A
1
1
0
0
98
C
A
8
CONSERVATION
2AFG|1JQZ
60|180
null
98
A
G
false
false
0.134371
13.601667
12,480
ProTherm
8
Fluorescence
GdnHCl
Sodium phosphate
50mM
25
1JQZ_A:C83A
null
null
4.97
1.14
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null
null
1.01
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null
null
null
null
null
null
null
yes
2.0
DG|DDG|M|CM|STATE|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
784
ARTICLE
Isolation of sublineage I?Nitrospira by a novel cultivation strategy.
2,014
10.1111/1462-2920.12248
25312601
Environ Microbiol;16;3030-40
3
Fujitani Hirotsugu|Ushiki Norisuke|Tsuneda Satoshi
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fireprotdb:8159
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,159
train
mutant
5,778
142
6,332
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C98T
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1
1
0
0
98
C
T
8
CONSERVATION
2AFG|1JQZ
60|180
null
98
A
G
false
false
0.134371
13.601667
12,482
ProTherm
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Fluorescence
GdnHCl
Sodium phosphate
50mM
25
1JQZ_A:C83T
null
null
4.9
1.21
null
null
null
1.03
4.73
null
null
null
null
null
null
null
yes
2.0
DG|DDG|M|CM|STATE|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
786
ARTICLE
Okra (Hibiscus esculentus) gum-alginate blend mucoadhesive beads for controlled glibenclamide release.
2,015
10.1016/j.ijbiomac.2014.10.002
25312603
Int J Biol Macromol;72;1069-75
3
Sinha Priyanka|Ubaidulla U|Nayak Amit Kumar
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fireprotdb:8160
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,160
train
mutant
5,779
142
6,333
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C98V
C98V
1
1
0
0
98
C
V
8
CONSERVATION
2AFG|1JQZ
60|180
null
98
A
G
false
false
0.134371
13.601667
12,483
ProTherm
8
Fluorescence
GdnHCl
Sodium phosphate
50mM
25
1JQZ_A:C83V
null
null
3.51
2.6
null
null
null
0.7
4.99
null
null
null
null
null
null
null
yes
2.0
DG|DDG|M|CM|STATE|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
787
ARTICLE
Proton spectroscopic imaging of brain metabolites in basal ganglia of healthy older adults.
2,015
10.1007/s10334-014-0465-0
25312604
MAGMA;28;251-7
3
Parikh Jehill|Thrippleton Michael J|Murray Catherine
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fireprotdb:8161
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,161
train
mutant
6,956
142
7,607
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C98S|C132S
C98S|C132S
2
2
0
0
98
C
S
8
CONSERVATION
2AFG|1JQZ
60|180
null
98|132
A
G|B
false
false
12.649199
18.532083
14,818
ProTherm
6.6
DSC
Thermal
GuHCl/ADA
0.7 M
null
2AFG_A:C83S 2AFG_A:C117S
25.95
-13.5
null
null
30.5
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DH|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
395
ARTICLE
Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life.
2,000
10.1021/bi9927742
10852713
Biochemistry;39;7153-8
4
Blaber M|Khurana A|Culajay J F|Blaber S I
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fireprotdb:8163
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,163
train
mutant
6,956
142
7,607
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C98S|C132S
C98S|C132S
2
2
0
0
98
C
S
8
CONSERVATION
2AFG|1JQZ
60|180
null
98|132
A
G|B
false
false
12.649199
18.532083
15,411
ProTherm
6.6
DSC
Thermal
GuHCl/ADA
0.7 M
25
2AFG_A:C83S 2AFG_A:C117S
null
null
null
1.82
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
395
ARTICLE
Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life.
2,000
10.1021/bi9927742
10852713
Biochemistry;39;7153-8
4
Blaber M|Khurana A|Culajay J F|Blaber S I
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fireprotdb:8164
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,164
train
mutant
7,957
142
8,681
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C98T|C132V
C98T|C132V
2
2
0
0
98
C
T
8
CONSERVATION
2AFG|1JQZ
60|180
null
98|132
A
G|B
false
false
12.649199
18.532083
17,005
ProTherm
6.6
CD, Fluorescence
GdnHCl
ADA (N-(2-acetamide)iminodiaceticacid)
25
2AFG_A:C83T 2AFG_A:C117V
null
null
4.18
-1.46
null
null
null
0.81
5.19
null
null
null
null
null
null
null
Yes (>80%)
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION
235
ARTICLE
The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
2,009
10.1016/j.jmb.2009.08.026
19695265
J Mol Biol;393;113-27
2
Lee Jihun|Blaber Michael
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fireprotdb:8165
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,165
train
mutant
7,957
142
8,681
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C98T|C132V
C98T|C132V
2
2
0
0
98
C
T
8
CONSERVATION
2AFG|1JQZ
60|180
null
98|132
A
G|B
false
false
12.649199
18.532083
17,007
ProTherm
6.6
CD, Fluorescence
GdnHCl
ADA (N-(2-acetamide)iminodiaceticacid)
25
2AFG_A:C83T 2AFG_A:C117V
null
null
5.76
0.45
null
null
null
1.21
4.76
null
null
null
null
null
null
null
Yes (>80%)
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION
235
ARTICLE
The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
2,009
10.1016/j.jmb.2009.08.026
19695265
J Mol Biol;393;113-27
2
Lee Jihun|Blaber Michael
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fireprotdb:8166
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,166
train
mutant
1,347
142
1,521
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
F100W
F100W
1
1
0
0
100
F
W
9
CONSERVATION
2AFG|1JQZ
60|180
null
100
A
E
true
false
0.125483
15.377727
2,658
ProTherm
6.6
DSC
Thermal
ADA (N-(2-acetamide)iminodiaceticacid)
null
2AFG_A:F85W
39.45
-0.3
null
-0.07
63.58
null
null
null
null
null
null
null
null
null
null
null
Yes (>80%)
TM|DTM|DH|DDG|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION
235
ARTICLE
The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
2,009
10.1016/j.jmb.2009.08.026
19695265
J Mol Biol;393;113-27
2
Lee Jihun|Blaber Michael
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fireprotdb:8167
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,167
train
mutant
1,347
142
1,521
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
F100W
F100W
1
1
0
0
100
F
W
9
CONSERVATION
2AFG|1JQZ
60|180
null
100
A
E
true
false
0.125483
15.377727
10,327
ProTherm
6.6
CD, Fluorescence
GdnHCl
ADA (N-(2-acetamide)iminodiaceticacid)
25
2AFG_A:F85W
null
null
5.33
0.1
null
null
null
1.13
4.71
null
null
null
null
null
null
null
Yes (>80%)
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION
235
ARTICLE
The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
2,009
10.1016/j.jmb.2009.08.026
19695265
J Mol Biol;393;113-27
2
Lee Jihun|Blaber Michael
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fireprotdb:8168
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,168
train
mutant
2,131
142
2,416
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
H108G
H108G
1
1
0
0
108
H
G
6
CONSERVATION
2AFG|1JQZ
60|180
null
108
A
S|T
false
false
118.592499
20.3
4,198
ProTherm
6.6
DSC
Thermal
GuHCl/ADA
0.7 M
null
2AFG_A:H93G
46.75
7.3
null
null
79.49
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DH|REVERSIBILITY
AUTOMUTE_S1749.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
395
ARTICLE
Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life.
2,000
10.1021/bi9927742
10852713
Biochemistry;39;7153-8
4
Blaber M|Khurana A|Culajay J F|Blaber S I
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fireprotdb:8170
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,170
train
mutant
2,131
142
2,416
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
H108G
H108G
1
1
0
0
108
H
G
6
CONSERVATION
2AFG|1JQZ
60|180
null
108
A
S|T
false
false
118.592499
20.3
9,052
ProTherm
6.6
Fluorescence
GdnHCl
N-(2-acetamido)-iminodiacetic acid
20 mM
25
NaCl
100 mM
2AFG_A:H93G
null
null
6.84
-1.79
null
null
null
1.45
4.73
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
615
ARTICLE
Identification of a key structural element for protein folding within beta-hairpin turns.
2,003
10.1016/s0022-2836(03)00321-8
12729767
J Mol Biol;328;951-61
5
Lee Jihun|Blaber Michael|Kim Jaewon|Brych Stephen R|Logan Timothy M
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[{"datasets":[],"id":30713,"numValue":6.84,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":30714,"numValue":-1.79,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30715,"numValue":4.73,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":30716,"numValue":1.45,"references":[]...
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fireprotdb:8171
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,171
train
mutant
2,131
142
2,416
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
H108G
H108G
1
1
0
0
108
H
G
6
CONSERVATION
2AFG|1JQZ
60|180
null
108
A
S|T
false
false
118.592499
20.3
11,127
ProTherm
6.6
DSC
GdnHCl
GuHCl/ADA
0.7 M
25
2AFG_A:H93G
null
null
6.26
-1.31
null
null
null
null
null
null
null
null
null
null
null
null
yes
DG|DDG|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
395
ARTICLE
Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life.
2,000
10.1021/bi9927742
10852713
Biochemistry;39;7153-8
4
Blaber M|Khurana A|Culajay J F|Blaber S I
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"GuHCl/ADA","type":"BUFFER"},{"numValue":null,"strValue":"0.7 M","type":"BUFFER_C...
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[{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8172
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,172
train
mutant
2,131
142
2,416
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
H108G
H108G
1
1
0
0
108
H
G
6
CONSERVATION
2AFG|1JQZ
60|180
null
108
A
S|T
false
false
118.592499
20.3
11,130
ProTherm
6.6
DSC
Thermal
GuHCl/ADA
0.7 M
25
2AFG_A:H93G
null
null
null
-0.55
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
khan_protherm_data_mapped.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
395
ARTICLE
Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life.
2,000
10.1021/bi9927742
10852713
Biochemistry;39;7153-8
4
Blaber M|Khurana A|Culajay J F|Blaber S I
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"GuHCl/ADA","type":"BUFFER"},{"numValue":null,"strValue":"0.7 M","type":"BUFFER_...
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fireprotdb:8173
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,173
train
mutant
3,900
142
4,394
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
H108A
H108A
1
1
0
0
108
H
A
6
CONSERVATION
2AFG|1JQZ
60|180
null
108
A
S|T
false
false
118.592499
20.3
9,053
ProTherm
6.6
Fluorescence
GdnHCl
N-(2-acetamido)-iminodiacetic acid
20 mM
25
NaCl
100 mM
2AFG_A:H93A
null
null
4.61
0.43
null
null
null
0.95
4.88
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
615
ARTICLE
Identification of a key structural element for protein folding within beta-hairpin turns.
2,003
10.1016/s0022-2836(03)00321-8
12729767
J Mol Biol;328;951-61
5
Lee Jihun|Blaber Michael|Kim Jaewon|Brych Stephen R|Logan Timothy M
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"N-(2-acetamido)-iminodiacetic acid","type":"BUFFER"},{"numValue":null,"...
[{"datasets":[],"id":30718,"numValue":4.61,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":30719,"numValue":0.43,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30720,"numValue":4.88,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":30721,"numValue":0.95,"references":[],...
[{"id":8710,"numValue":6.0,"position":108,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8174
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,174
train
mutant
3,901
142
4,395
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
H108N
H108N
1
1
0
0
108
H
N
6
CONSERVATION
2AFG|1JQZ
60|180
null
108
A
S|T
false
false
118.592499
20.3
9,054
ProTherm
6.6
Fluorescence
GdnHCl
N-(2-acetamido)-iminodiacetic acid
20 mM
25
NaCl
100 mM
2AFG_A:H93N
null
null
5.33
-0.29
null
null
null
1.13
4.73
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
615
ARTICLE
Identification of a key structural element for protein folding within beta-hairpin turns.
2,003
10.1016/s0022-2836(03)00321-8
12729767
J Mol Biol;328;951-61
5
Lee Jihun|Blaber Michael|Kim Jaewon|Brych Stephen R|Logan Timothy M
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"N-(2-acetamido)-iminodiacetic acid","type":"BUFFER"},{"numValue":null,"...
[{"datasets":[],"id":30723,"numValue":5.33,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":30724,"numValue":-0.29,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30725,"numValue":4.73,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":30726,"numValue":1.13,"references":[]...
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fireprotdb:8175
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,175
train
mutant
944
142
1,067
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
H117Y
H117Y
1
1
0
0
117
H
Y
6
CONSERVATION
2AFG|1JQZ
60|180
null
117
A
T
false
false
10.681715
21.634
1,703
ProTherm
7.3
Fluorescence
Thermal
H3PO4
25 mM
null
2AFG_A:H102Y
41.7
1.9
null
null
null
null
75.7
null
null
null
null
null
null
null
null
null
Yes
TM|DTM|DHVH|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H102Y","typ...
[{"datasets":[],"id":6360,"numValue":41.7,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":6361,"numValue":1.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":6362,"numValue":75.7,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":6363,"numValue":null,"references":[],"s...
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fireprotdb:8176
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,176
train
mutant
944
142
1,067
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
H117Y
H117Y
1
1
0
0
117
H
Y
6
CONSERVATION
2AFG|1JQZ
60|180
null
117
A
T
false
false
10.681715
21.634
1,708
ProTherm
7.3
CD
Thermal
H3PO4
25 mM
null
2AFG_A:H102Y
41.2
0.5
null
null
null
null
66.3
null
null
null
null
null
null
null
null
null
Yes
TM|DTM|DHVH|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H102Y","type":"_PDB_C...
[{"datasets":[],"id":6380,"numValue":41.2,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":6381,"numValue":0.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":6382,"numValue":66.3,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":6383,"numValue":null,"references":[],"s...
[{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8177
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,177
train
mutant
944
142
1,067
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
H117Y
H117Y
1
1
0
0
117
H
Y
6
CONSERVATION
2AFG|1JQZ
60|180
null
117
A
T
false
false
10.681715
21.634
8,075
ProTherm
7.3
CD
Thermal
H3PO4
25 mM
40.7
2AFG_A:H102Y
null
null
null
-0.1
null
null
null
null
null
null
null
null
null
null
null
null
Yes
DDG|REVERSIBILITY
khan_protherm_data_mapped.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":40.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"...
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[{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8178
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,178
train
mutant
944
142
1,067
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
H117Y
H117Y
1
1
0
0
117
H
Y
6
CONSERVATION
2AFG|1JQZ
60|180
null
117
A
T
false
false
10.681715
21.634
8,152
ProTherm
7.3
Fluorescence
Thermal
H3PO4
25 mM
39.8
2AFG_A:H102Y
null
null
null
-0.4
null
null
null
null
null
null
null
null
null
null
null
null
Yes
DDG|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU...
[{"datasets":[],"id":27694,"numValue":-0.4,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27695,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}]
[{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8179
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,179
train
mutant
944
142
1,067
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
H117Y
H117Y
1
1
0
0
117
H
Y
6
CONSERVATION
2AFG|1JQZ
60|180
null
117
A
T
false
false
10.681715
21.634
12,707
ProTherm
7.3
Fluorescence
GdnHCl
H3PO4
25 mM
20.15
2AFG_A:H102Y
null
null
5.97
-0.44
null
null
null
1.27
4.69
null
null
null
null
null
null
null
Yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":20.15,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU...
[{"datasets":[],"id":46084,"numValue":5.97,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":46085,"numValue":-0.44,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46086,"numValue":4.69,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":46087,"numValue":1.27,"references":[]...
[{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8181
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,181
train
mutant
7,422
142
8,105
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
H117Y|F123Y
H117Y|F123Y
2
2
0
0
117
H
Y
6
CONSERVATION
2AFG|1JQZ
60|180
null
117|123
A
T|B
false
false
8.338962
18.471318
15,832
ProTherm
7.3
CD
Thermal
H3PO4
25 mM
null
2AFG_A:H102Y 2AFG_A:F108Y
43.1
2.4
null
null
null
null
68.1
null
null
null
null
null
null
null
null
null
Yes
TM|DTM|DHVH|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:H102Y 2AFG_A:F108Y","...
[{"datasets":[],"id":58155,"numValue":43.1,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":58156,"numValue":2.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":58157,"numValue":68.1,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":58158,"numValue":null,"references":[...
[{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8182
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,182
train
mutant
7,422
142
8,105
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
H117Y|F123Y
H117Y|F123Y
2
2
0
0
117
H
Y
6
CONSERVATION
2AFG|1JQZ
60|180
null
117|123
A
T|B
false
false
8.338962
18.471318
16,802
ProTherm
7.3
CD
Thermal
H3PO4
25 mM
40.7
2AFG_A:H102Y 2AFG_A:F108Y
null
null
null
-0.5
null
null
null
null
null
null
null
null
null
null
null
null
Yes
DDG|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":40.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"...
[{"datasets":[],"id":61737,"numValue":-0.5,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61738,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}]
[{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8183
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,183
train
mutant
7,422
142
8,105
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
H117Y|F123Y
H117Y|F123Y
2
2
0
0
117
H
Y
6
CONSERVATION
2AFG|1JQZ
60|180
null
117|123
A
T|B
false
false
8.338962
18.471318
16,816
ProTherm
7.3
Fluorescence
Thermal
H3PO4
25 mM
39.8
2AFG_A:H102Y 2AFG_A:F108Y
null
null
null
-0.66
null
null
null
null
null
null
null
null
null
null
null
null
Yes
DDG|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU...
[{"datasets":[],"id":61766,"numValue":-0.66,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":61767,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}]
[{"id":8719,"numValue":6.0,"position":117,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8185
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,185
train
mutant
3,899
142
4,393
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
N121G
N121G
1
1
0
0
121
N
G
2
CONSERVATION
2AFG|1JQZ
60|180
null
121
A
T
false
false
72.114169
26.65
9,051
ProTherm
6.6
Fluorescence
GdnHCl
N-(2-acetamido)-iminodiacetic acid
20 mM
25
NaCl
100 mM
2AFG_A:N106G
null
null
5.43
-0.38
null
null
null
1.1
4.95
null
null
null
null
null
null
null
yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
615
ARTICLE
Identification of a key structural element for protein folding within beta-hairpin turns.
2,003
10.1016/s0022-2836(03)00321-8
12729767
J Mol Biol;328;951-61
5
Lee Jihun|Blaber Michael|Kim Jaewon|Brych Stephen R|Logan Timothy M
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"N-(2-acetamido)-iminodiacetic acid","type":"BUFFER"},{"numValue":null,"...
[{"datasets":[],"id":30708,"numValue":5.43,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":30709,"numValue":-0.38,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":30710,"numValue":4.95,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":30711,"numValue":1.1,"references":[],...
[{"id":8723,"numValue":2.0,"position":121,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8186
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,186
train
mutant
945
142
1,068
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
F123Y
F123Y
1
1
0
0
123
F
Y
6
CONSERVATION
2AFG|1JQZ
60|180
null
123
A
B
false
false
5.99621
15.308636
1,704
ProTherm
7.3
Fluorescence
Thermal
H3PO4
25 mM
null
2AFG_A:F108Y
41.4
1.6
null
null
null
null
79.6
null
null
null
null
null
null
null
null
null
Yes
TM|DTM|DHVH|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:F108Y","typ...
[{"datasets":[],"id":6364,"numValue":41.4,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":6365,"numValue":1.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":6366,"numValue":79.6,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":6367,"numValue":null,"references":[],"s...
[{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8187
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,187
train
mutant
945
142
1,068
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
F123Y
F123Y
1
1
0
0
123
F
Y
6
CONSERVATION
2AFG|1JQZ
60|180
null
123
A
B
false
false
5.99621
15.308636
1,709
ProTherm
7.3
CD
Thermal
H3PO4
25 mM
null
2AFG_A:F108Y
42.3
1.6
null
null
null
null
72.6
null
null
null
null
null
null
null
null
null
Yes
TM|DTM|DHVH|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:F108Y","type":"_PDB_C...
[{"datasets":[],"id":6384,"numValue":42.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":6385,"numValue":1.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":6386,"numValue":72.6,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":6387,"numValue":null,"references":[],"s...
[{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8188
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,188
train
mutant
945
142
1,068
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
F123Y
F123Y
1
1
0
0
123
F
Y
6
CONSERVATION
2AFG|1JQZ
60|180
null
123
A
B
false
false
5.99621
15.308636
8,076
ProTherm
7.3
CD
Thermal
H3PO4
25 mM
40.7
2AFG_A:F108Y
null
null
null
-0.33
null
null
null
null
null
null
null
null
null
null
null
null
Yes
DDG|REVERSIBILITY
khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":40.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"...
[{"datasets":["khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27470,"numValue":-0.33,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27471,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}]
[{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8189
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,189
train
mutant
945
142
1,068
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
F123Y
F123Y
1
1
0
0
123
F
Y
6
CONSERVATION
2AFG|1JQZ
60|180
null
123
A
B
false
false
5.99621
15.308636
8,153
ProTherm
7.3
Fluorescence
Thermal
H3PO4
25 mM
39.8
2AFG_A:F108Y
null
null
null
-0.33
null
null
null
null
null
null
null
null
null
null
null
null
Yes
DDG|REVERSIBILITY
khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU...
[{"datasets":["khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27696,"numValue":-0.33,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27697,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}]
[{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8190
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,190
train
mutant
945
142
1,068
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
F123Y
F123Y
1
1
0
0
123
F
Y
6
CONSERVATION
2AFG|1JQZ
60|180
null
123
A
B
false
false
5.99621
15.308636
12,708
ProTherm
7.3
Fluorescence
GdnHCl
H3PO4
25 mM
20.15
2AFG_A:F108Y
null
null
6.47
-0.94
null
null
null
1.22
5.3
null
null
null
null
null
null
null
Yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":20.15,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU...
[{"datasets":[],"id":46089,"numValue":6.47,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":46090,"numValue":-0.94,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46091,"numValue":5.3,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":46092,"numValue":1.22,"references":[],...
[{"id":8725,"numValue":6.0,"position":123,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8191
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,191
train
mutant
128
142
145
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
V124L
V124L
1
1
0
0
124
V
L
7
CONSERVATION
2AFG|1JQZ
60|180
null
124
A
L
true
false
2.485862
13.180714
240
ProTherm
6.6
DSC
Thermal
N-(2-acetamido)iminodiacetic acid(ADA)
20 mM
null
NaCl
100 mM
2AFG_A:V109L
36.75
-3.3
null
null
52.34
null
43.44
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DH|DHVH|REVERSIBILITY
AUTOMUTE_S1749.csv|Saraboji_S1791.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
20
ARTICLE
Stabilization of hen egg white lysozyme by a cavity-filling mutation.
2,001
10.1110/ps.37401
11266617
Protein Sci;10;313-20
5
Ueda T|Imoto T|Ohmura T|Ootsuka K|Saito M
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"N-(2-acetamido)iminodiacetic acid(ADA)","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strVa...
[{"datasets":[],"id":987,"numValue":36.75,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1749.csv","Saraboji_S1791.csv"],"id":988,"numValue":-3.3,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":989,"numValue":52.34,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":...
[{"id":8726,"numValue":7.0,"position":124,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8192
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,192
train
mutant
128
142
145
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
V124L
V124L
1
1
0
0
124
V
L
7
CONSERVATION
2AFG|1JQZ
60|180
null
124
A
L
true
false
2.485862
13.180714
8,083
ProTherm
6.6
DSC
Thermal
N-(2-acetamido)iminodiacetic acid(ADA)
20 mM
40.2
NaCl
100 mM
2AFG_A:V109L
null
null
null
0.57
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
20
ARTICLE
Stabilization of hen egg white lysozyme by a cavity-filling mutation.
2,001
10.1110/ps.37401
11266617
Protein Sci;10;313-20
5
Ueda T|Imoto T|Ohmura T|Ootsuka K|Saito M
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":40.2,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"N-(2-acetamido)iminodiacetic acid(ADA)","type":"BUFFER"},{"numValue":null,"strV...
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[{"id":8726,"numValue":7.0,"position":124,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8193
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,193
train
mutant
946
142
1,069
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
V124I
V124I
1
1
0
0
124
V
I
7
CONSERVATION
2AFG|1JQZ
60|180
null
124
A
L
true
false
2.485862
13.180714
1,705
ProTherm
7.3
Fluorescence
Thermal
H3PO4
25 mM
null
2AFG_A:V109I
39.5
-0.3
null
null
null
null
61.4
null
null
null
null
null
null
null
null
null
Yes
TM|DTM|DHVH|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:V109I","typ...
[{"datasets":[],"id":6368,"numValue":39.5,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":6369,"numValue":-0.3,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":6370,"numValue":61.4,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":6371,"numValue":null,"references":[],"...
[{"id":8726,"numValue":7.0,"position":124,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8194
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,194
train
mutant
946
142
1,069
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
V124I
V124I
1
1
0
0
124
V
I
7
CONSERVATION
2AFG|1JQZ
60|180
null
124
A
L
true
false
2.485862
13.180714
1,710
ProTherm
7.3
CD
Thermal
H3PO4
25 mM
null
2AFG_A:V109I
40.3
-0.4
null
null
null
null
61.6
null
null
null
null
null
null
null
null
null
Yes
TM|DTM|DHVH|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:V109I","type":"_PDB_C...
[{"datasets":[],"id":6388,"numValue":40.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":6389,"numValue":-0.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":6390,"numValue":61.6,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":6391,"numValue":null,"references":[],"...
[{"id":8726,"numValue":7.0,"position":124,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8195
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,195
train
mutant
946
142
1,069
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
V124I
V124I
1
1
0
0
124
V
I
7
CONSERVATION
2AFG|1JQZ
60|180
null
124
A
L
true
false
2.485862
13.180714
8,077
ProTherm
7.3
CD
Thermal
H3PO4
25 mM
40.7
2AFG_A:V109I
null
null
null
0.11
null
null
null
null
null
null
null
null
null
null
null
null
Yes
DDG|REVERSIBILITY
potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":40.7,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"...
[{"datasets":["potapov_with_uniprot_mapping.csv"],"id":27472,"numValue":0.11,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27473,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}]
[{"id":8726,"numValue":7.0,"position":124,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8196
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,196
train
mutant
946
142
1,069
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
V124I
V124I
1
1
0
0
124
V
I
7
CONSERVATION
2AFG|1JQZ
60|180
null
124
A
L
true
false
2.485862
13.180714
8,154
ProTherm
7.3
Fluorescence
Thermal
H3PO4
25 mM
39.8
2AFG_A:V109I
null
null
null
0.08
null
null
null
null
null
null
null
null
null
null
null
null
Yes
DDG|REVERSIBILITY
khan_protherm_data_mapped.csv|potapov_with_uniprot_mapping.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":39.8,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU...
[{"datasets":["khan_protherm_data_mapped.csv","potapov_with_uniprot_mapping.csv"],"id":27698,"numValue":0.08,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":27699,"numValue":null,"references":[],"strValue":"Yes","type":"REVERSIBILITY"}]
[{"id":8726,"numValue":7.0,"position":124,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8197
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,197
train
mutant
946
142
1,069
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
V124I
V124I
1
1
0
0
124
V
I
7
CONSERVATION
2AFG|1JQZ
60|180
null
124
A
L
true
false
2.485862
13.180714
12,709
ProTherm
7.3
Fluorescence
GdnHCl
H3PO4
25 mM
20.15
2AFG_A:V109I
null
null
5.59
-0.06
null
null
null
1.12
5.03
null
null
null
null
null
null
null
Yes
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
180
ARTICLE
Design of fully active FGF-1 variants with increased stability.
2,004
10.1093/protein/gzh076
15469994
Protein Eng Des Sel;17;603-11
4
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":20.15,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"H3PO4","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BU...
[{"datasets":[],"id":46094,"numValue":5.59,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":46095,"numValue":-0.06,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":46096,"numValue":5.03,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":46097,"numValue":1.12,"references":[]...
[{"id":8726,"numValue":7.0,"position":124,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8198
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,198
train
mutant
2,246
142
2,557
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K127N
K127N
1
1
0
0
127
K
N
8
CONSERVATION
2AFG|1JQZ
60|180
null
127
A
L
true
true
82.932681
27.051111
4,450
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
43.8
-3.5
null
null
75.6
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":16488,"numValue":43.8,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16489,"numValue":-3.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16490,"numValue":75.6,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16491,"numValue":2.0,"references":[],...
[{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8199
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,199
train
mutant
2,246
142
2,557
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K127N
K127N
1
1
0
0
127
K
N
8
CONSERVATION
2AFG|1JQZ
60|180
null
127
A
L
true
true
82.932681
27.051111
4,456
ProTherm
7.3
fluorescence
Thermal
sodium phosphate
25 mM
null
42.6
-2.8
null
null
72.6
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":16518,"numValue":42.6,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16519,"numValue":-2.8,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16520,"numValue":72.6,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16521,"numValue":2.0,"references":[],...
[{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8200
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,200
train
mutant
2,246
142
2,557
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K127N
K127N
1
1
0
0
127
K
N
8
CONSERVATION
2AFG|1JQZ
60|180
null
127
A
L
true
true
82.932681
27.051111
4,462
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
43.2
-2.5
null
null
68.1
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":16548,"numValue":43.2,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16549,"numValue":-2.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16550,"numValue":68.1,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16551,"numValue":2.0,"references":[],...
[{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8201
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,201
train
mutant
2,246
142
2,557
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K127N
K127N
1
1
0
0
127
K
N
8
CONSERVATION
2AFG|1JQZ
60|180
null
127
A
L
true
true
82.932681
27.051111
4,468
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
46.5
7.6
null
null
65.1
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":16578,"numValue":46.5,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16579,"numValue":7.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16580,"numValue":65.1,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16581,"numValue":2.0,"references":[],"...
[{"id":8729,"numValue":8.0,"position":127,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8202
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,202
train
mutant
2,247
142
2,558
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K127A
K127A
1
1
0
0
127
K
A
8
CONSERVATION
2AFG|1JQZ
60|180
null
127
A
L
true
true
82.932681
27.051111
4,451
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
40
0.3
null
null
65
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
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fireprotdb:8203
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,203
train
mutant
2,247
142
2,558
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K127A
K127A
1
1
0
0
127
K
A
8
CONSERVATION
2AFG|1JQZ
60|180
null
127
A
L
true
true
82.932681
27.051111
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ProTherm
7.3
fluorescence
Thermal
sodium phosphate
25 mM
null
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0.2
null
null
66
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
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fireprotdb:8204
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,204
train
mutant
2,247
142
2,558
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K127A
K127A
1
1
0
0
127
K
A
8
CONSERVATION
2AFG|1JQZ
60|180
null
127
A
L
true
true
82.932681
27.051111
4,463
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
39.8
0.9
null
null
54
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
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fireprotdb:8205
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,205
train
mutant
2,247
142
2,558
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K127A
K127A
1
1
0
0
127
K
A
8
CONSERVATION
2AFG|1JQZ
60|180
null
127
A
L
true
true
82.932681
27.051111
4,469
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
43.7
10.4
null
null
57.3
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
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[{"datasets":[],"id":16583,"numValue":43.7,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16584,"numValue":10.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16585,"numValue":57.3,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16586,"numValue":2.0,"references":[],...
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fireprotdb:8209
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,209
train
mutant
2,248
142
2,559
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K127E
K127E
1
1
0
0
127
K
E
8
CONSERVATION
2AFG|1JQZ
60|180
null
127
A
L
true
true
82.932681
27.051111
4,470
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
38.5
15.6
null
null
57.1
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":16588,"numValue":38.5,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16589,"numValue":15.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16590,"numValue":57.1,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16591,"numValue":2.0,"references":[],...
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fireprotdb:8210
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,210
train
mutant
7,668
142
8,371
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K127N|K133E
K127N|K133E
2
2
0
0
127
K
N
8
CONSERVATION
2AFG|1JQZ
60|180
null
127|133
A
L
true
true
61.208894
24.714167
16,243
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
41.8
-1.5
null
null
66.6
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":59482,"numValue":41.8,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59483,"numValue":-1.5,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59484,"numValue":66.6,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59485,"numValue":2.0,"references":[],...
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fireprotdb:8211
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,211
train
mutant
7,668
142
8,371
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K127N|K133E
K127N|K133E
2
2
0
0
127
K
N
8
CONSERVATION
2AFG|1JQZ
60|180
null
127|133
A
L
true
true
61.208894
24.714167
16,254
ProTherm
7.3
fluorescence
Thermal
sodium phosphate
25 mM
null
41.4
-1.6
null
null
64.4
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":59537,"numValue":41.4,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59538,"numValue":-1.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59539,"numValue":64.4,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59540,"numValue":2.0,"references":[],...
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fireprotdb:8213
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,213
train
mutant
7,668
142
8,371
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K127N|K133E
K127N|K133E
2
2
0
0
127
K
N
8
CONSERVATION
2AFG|1JQZ
60|180
null
127|133
A
L
true
true
61.208894
24.714167
16,276
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
33
21.1
null
null
53
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":59647,"numValue":33.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":59648,"numValue":21.1,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":59649,"numValue":53.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":59650,"numValue":2.0,"references":[],...
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fireprotdb:8214
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,214
train
mutant
2,130
142
2,415
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C132S
C132S
1
1
0
0
132
C
S
4
CONSERVATION
2AFG|1JQZ
60|180
null
132
A
B
false
false
25.164027
23.4625
4,197
ProTherm
6.6
DSC
Thermal
GuHCl/ADA
0.7 M
null
2AFG_A:C117S
37.45
-2
null
null
52.44
null
null
null
null
null
null
null
null
null
null
null
yes
TM|DTM|DH|REVERSIBILITY
AUTOMUTE_S1749.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
395
ARTICLE
Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life.
2,000
10.1021/bi9927742
10852713
Biochemistry;39;7153-8
4
Blaber M|Khurana A|Culajay J F|Blaber S I
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"GuHCl/ADA","type":"BUFFER"},{"numValue":null,"strValue":"0.7 M","type":"BUFFER_CONC"},{"numValue":null,"strValue":"2AFG_A:C117S","type":"_...
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fireprotdb:8215
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,215
train
mutant
2,130
142
2,415
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C132S
C132S
1
1
0
0
132
C
S
4
CONSERVATION
2AFG|1JQZ
60|180
null
132
A
B
false
false
25.164027
23.4625
8,155
ProTherm
6.6
DSC
Thermal
N-(2-acetamido)iminodiacetic acid (ADA)
20 mM
39.6
NaCl
0.1 M
2AFG_A:C117S
null
null
null
0.26
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
khan_protherm_data_mapped.csv
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC|_PDB_CHAIN_MUTATION
395
ARTICLE
Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life.
2,000
10.1021/bi9927742
10852713
Biochemistry;39;7153-8
4
Blaber M|Khurana A|Culajay J F|Blaber S I
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":39.6,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"N-(2-acetamido)iminodiacetic acid (ADA)","type":"BUFFER"},{"numValue":null,"str...
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fireprotdb:8217
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,217
train
mutant
2,130
142
2,415
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C132S
C132S
1
1
0
0
132
C
S
4
CONSERVATION
2AFG|1JQZ
60|180
null
132
A
B
false
false
25.164027
23.4625
11,129
ProTherm
6.6
DSC
Thermal
GuHCl/ADA
0.7 M
25
2AFG_A:C117S
null
null
null
0.62
null
null
null
null
null
null
null
null
null
null
null
null
yes
DDG|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
395
ARTICLE
Thermodynamic characterization of mutants of human fibroblast growth factor 1 with an increased physiological half-life.
2,000
10.1021/bi9927742
10852713
Biochemistry;39;7153-8
4
Blaber M|Khurana A|Culajay J F|Blaber S I
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"GuHCl/ADA","type":"BUFFER"},{"numValue":null,"strValue":"0.7 M","type":"BUFFER_...
[{"datasets":[],"id":38295,"numValue":0.62,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":38296,"numValue":null,"references":[],"strValue":"yes","type":"REVERSIBILITY"}]
[{"id":8734,"numValue":4.0,"position":132,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8218
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,218
train
mutant
2,130
142
2,415
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C132S
C132S
1
1
0
0
132
C
S
4
CONSERVATION
2AFG|1JQZ
60|180
null
132
A
B
false
false
25.164027
23.4625
12,485
ProTherm
8
Fluorescence
GdnHCl
Sodium phosphate
50mM
25
1JQZ_A:C117S
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null
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0.21
null
null
null
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null
null
null
null
null
null
null
yes
2.0
DG|DDG|M|CM|STATE|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
789
ARTICLE
Invasive plant species set up their own niche.
2,014
10.1111/nph.13070
25312606
New Phytol;204;435-437
2
Salles Joana Falc?o|Mallon Cyrus A
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fireprotdb:8221
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,221
train
mutant
5,781
142
6,335
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C132T
C132T
1
1
0
0
132
C
T
4
CONSERVATION
2AFG|1JQZ
60|180
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50mM
25
1JQZ_A:C117T
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null
null
null
null
null
null
yes
2.0
DG|DDG|M|CM|STATE|REVERSIBILITY
BUFFER_CONC|PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION
790
ARTICLE
The effective papilla hypothesis.
2,014
10.1111/nph.13026
25312607
New Phytol;204;438-440
1
H?ckelhoven Ralph
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fireprotdb:8222
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,222
train
mutant
5,782
142
6,336
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
C132V
C132V
1
1
0
0
132
C
V
4
CONSERVATION
2AFG|1JQZ
60|180
null
132
A
B
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false
25.164027
23.4625
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ProTherm
8
Fluorescence
GdnHCl
Sodium phosphate
50mM
25
1JQZ_A:C117V
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null
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null
null
null
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null
null
null
null
null
null
null
yes
2.0
DG|DDG|M|CM|STATE|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
791
ARTICLE
Extreme temporal interpolation of sparse data is not a sufficient basis to substantiate a claim to have uncovered Pleistocene forest microrefugia.
2,014
10.1111/nph.12941
25312608
New Phytol;204;447-449
1
Huntley Brian
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fireprotdb:8223
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,223
train
mutant
2,245
142
2,556
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K133E
K133E
1
1
0
0
133
K
E
7
CONSERVATION
2AFG|1JQZ
60|180
null
133
A
L
true
true
39.485108
22.377222
4,449
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
39.4
0.9
null
null
60.5
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":16483,"numValue":39.4,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16484,"numValue":0.9,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16485,"numValue":60.5,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16486,"numValue":2.0,"references":[],"...
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fireprotdb:8225
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,225
train
mutant
2,245
142
2,556
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K133E
K133E
1
1
0
0
133
K
E
7
CONSERVATION
2AFG|1JQZ
60|180
null
133
A
L
true
true
39.485108
22.377222
4,461
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
40.3
0.4
null
null
55.9
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":16543,"numValue":40.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16544,"numValue":0.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16545,"numValue":55.9,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16546,"numValue":2.0,"references":[],"...
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fireprotdb:8226
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,226
train
mutant
2,245
142
2,556
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K133E
K133E
1
1
0
0
133
K
E
7
CONSERVATION
2AFG|1JQZ
60|180
null
133
A
L
true
true
39.485108
22.377222
4,467
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
37.4
16.7
null
null
50.8
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
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[{"datasets":[],"id":16573,"numValue":37.4,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16574,"numValue":16.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16575,"numValue":50.8,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16576,"numValue":2.0,"references":[],...
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fireprotdb:8227
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,227
train
mutant
2,249
142
2,560
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K133A
K133A
1
1
0
0
133
K
A
7
CONSERVATION
2AFG|1JQZ
60|180
null
133
A
L
true
true
39.485108
22.377222
4,453
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
39.6
0.7
null
null
62.5
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
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[{"datasets":[],"id":16503,"numValue":39.6,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16504,"numValue":0.7,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16505,"numValue":62.5,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16506,"numValue":2.0,"references":[],"...
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fireprotdb:8228
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,228
train
mutant
2,249
142
2,560
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K133A
K133A
1
1
0
0
133
K
A
7
CONSERVATION
2AFG|1JQZ
60|180
null
133
A
L
true
true
39.485108
22.377222
4,459
ProTherm
7.3
fluorescence
Thermal
sodium phosphate
25 mM
null
39
0.8
null
null
59.7
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
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[{"datasets":[],"id":16533,"numValue":39.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16534,"numValue":0.8,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16535,"numValue":59.7,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16536,"numValue":2.0,"references":[],"...
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fireprotdb:8229
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,229
train
mutant
2,249
142
2,560
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K133A
K133A
1
1
0
0
133
K
A
7
CONSERVATION
2AFG|1JQZ
60|180
null
133
A
L
true
true
39.485108
22.377222
4,465
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
37.3
3.4
null
null
54.4
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
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[{"datasets":[],"id":16563,"numValue":37.3,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16564,"numValue":3.4,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16565,"numValue":54.4,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16566,"numValue":2.0,"references":[],"...
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fireprotdb:8231
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,231
train
mutant
2,250
142
2,561
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K133N
K133N
1
1
0
0
133
K
N
7
CONSERVATION
2AFG|1JQZ
60|180
null
133
A
L
true
true
39.485108
22.377222
4,454
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
28.5
11.8
null
null
42
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
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[{"datasets":[],"id":16508,"numValue":28.5,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16509,"numValue":11.8,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16510,"numValue":42.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16511,"numValue":2.0,"references":[],...
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fireprotdb:8232
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,232
train
mutant
2,250
142
2,561
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K133N
K133N
1
1
0
0
133
K
N
7
CONSERVATION
2AFG|1JQZ
60|180
null
133
A
L
true
true
39.485108
22.377222
4,460
ProTherm
7.3
fluorescence
Thermal
sodium phosphate
25 mM
null
28
11.8
null
null
47
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":16538,"numValue":28.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16539,"numValue":11.8,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16540,"numValue":47.0,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16541,"numValue":2.0,"references":[],...
[{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8234
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,234
train
mutant
2,250
142
2,561
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
K133N
K133N
1
1
0
0
133
K
N
7
CONSERVATION
2AFG|1JQZ
60|180
null
133
A
L
true
true
39.485108
22.377222
4,472
ProTherm
7.3
CD
Thermal
sodium phosphate
25 mM
null
33.5
20.6
null
null
48.4
null
null
null
null
null
null
null
null
null
null
null
yes
2.0
TM|DTM|DH|STATE|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
430
ARTICLE
Increased protein stability of FGF1 can compensate for its reduced affinity for heparin.
2,009
10.1074/jbc.M109.001289
19574212
J Biol Chem;284;25388-403
6
Krowarsch Daniel|Otlewski Jacek|Zakrzewska Malgorzata|Wiedlocha Antoni|Szlachcic Anna|Olsnes Sjur
[{"numValue":7.3,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"25 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":16598,"numValue":33.5,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":16599,"numValue":20.6,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":16600,"numValue":48.4,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":16601,"numValue":2.0,"references":[],...
[{"id":8735,"numValue":7.0,"position":133,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8235
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,235
train
mutant
1,348
142
1,522
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
F147W
F147W
1
1
0
0
147
F
W
9
CONSERVATION
2AFG|1JQZ
60|180
null
147
A
E
true
false
0.815638
12.665455
2,659
ProTherm
6.6
DSC
Thermal
ADA (N-(2-acetamide)iminodiaceticacid)
null
2AFG_A:F132W
40.95
1.2
null
0.29
69.07
null
null
null
null
null
null
null
null
null
null
null
Yes (>80%)
TM|DTM|DH|DDG|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION
235
ARTICLE
The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
2,009
10.1016/j.jmb.2009.08.026
19695265
J Mol Biol;393;113-27
2
Lee Jihun|Blaber Michael
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"DSC","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"ADA (N-(2-acetamide)iminodiaceticacid)","type":"BUFFER"},{"numValue":null,"strValue":"2AFG_A:F132W","type":"_PDB_CHAIN_MUTATION"}]
[{"datasets":[],"id":9749,"numValue":40.95,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":9750,"numValue":1.2,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":9751,"numValue":69.07,"references":[],"strValue":null,"type":"DH"},{"datasets":[],"id":9752,"numValue":0.29,"references":[],"s...
[{"id":8749,"numValue":9.0,"position":147,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8236
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,236
train
mutant
1,348
142
1,522
155
155
17
Fibroblast growth factor 1
Homo sapiens
1
17
Fibroblast growth factor 1
Homo sapiens
1
P05230
IPR002209|IPR008996
F147W
F147W
1
1
0
0
147
F
W
9
CONSERVATION
2AFG|1JQZ
60|180
null
147
A
E
true
false
0.815638
12.665455
10,328
ProTherm
6.6
CD, Fluorescence
GdnHCl
ADA (N-(2-acetamide)iminodiaceticacid)
25
2AFG_A:F132W
null
null
6.24
0.38
null
null
null
1.19
5.26
null
null
null
null
null
null
null
Yes (>80%)
DG|DDG|M|CM|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|_PDB_CHAIN_MUTATION
235
ARTICLE
The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
2,009
10.1016/j.jmb.2009.08.026
19695265
J Mol Biol;393;113-27
2
Lee Jihun|Blaber Michael
[{"numValue":6.6,"strValue":null,"type":"PH"},{"numValue":25.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"CD, Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"GdnHCl","type":"METHOD"},{"numValue":null,"strValue":"ADA (N-(2-acetamide)iminodiaceticacid)","type":"BUFFER"},{"numValue...
[{"datasets":[],"id":35427,"numValue":6.24,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":35428,"numValue":0.38,"references":[],"strValue":null,"type":"DDG"},{"datasets":[],"id":35429,"numValue":5.26,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":35430,"numValue":1.19,"references":[],...
[{"id":8749,"numValue":9.0,"position":147,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8237
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,237
train
sequence
146
146
-1
345
-1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
0
0
0
0
-1
null
null
false
false
null
null
20,393
ProTherm
7
Fluorescence
Urea
Potassium phosphate
50 mM
27
null
null
4.51
null
null
null
null
null
1.2
null
null
null
null
null
null
null
yes
3.0
DG|M|STATE|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC
1348
ARTICLE
Urea-induced unfolding and conformational stability of 3-isopropylmalate dehydrogenase from the Thermophile thermus thermophilus and its mesophilic counterpart from Escherichia coli.
1,999
10.1021/bi982380v
9930995
Biochemistry;38;1332-7
3
Yamagishi A|Oshima T|Motono C
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":27.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"50 mM"...
[{"datasets":[],"id":74590,"numValue":4.51,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":74591,"numValue":1.2,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":74592,"numValue":3.0,"references":[],"strValue":null,"type":"STATE"},{"datasets":[],"id":74593,"numValue":null,"references":[],...
fireprotdb:8238
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,238
train
sequence
146
146
-1
345
-1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
0
0
0
0
-1
null
null
false
false
null
null
20,394
ProTherm
7
Fluorescence
Urea
Potassium phosphate
50 mM
27
null
null
16.3
null
null
null
null
null
1.41
null
null
null
null
null
null
null
yes
3.0
DG|M|STATE|REVERSIBILITY
PH|EXP_TEMPERATURE|MEASURE|METHOD|BUFFER|BUFFER_CONC
1348
ARTICLE
Urea-induced unfolding and conformational stability of 3-isopropylmalate dehydrogenase from the Thermophile thermus thermophilus and its mesophilic counterpart from Escherichia coli.
1,999
10.1021/bi982380v
9930995
Biochemistry;38;1332-7
3
Yamagishi A|Oshima T|Motono C
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":27.0,"strValue":null,"type":"EXP_TEMPERATURE"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Urea","type":"METHOD"},{"numValue":null,"strValue":"Potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"50 mM"...
[{"datasets":[],"id":74594,"numValue":16.3,"references":[],"strValue":null,"type":"DG"},{"datasets":[],"id":74595,"numValue":1.41,"references":[],"strValue":null,"type":"M"},{"datasets":[],"id":74596,"numValue":3.0,"references":[],"strValue":null,"type":"STATE"},{"datasets":[],"id":74597,"numValue":null,"references":[]...
fireprotdb:8239
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,239
train
sequence
146
146
-1
345
-1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
0
0
0
0
-1
null
null
false
false
null
null
22,111
ProTherm
7
CD
Thermal
sodium phosphate
null
ammonium sulfate
1.0-1.5 M
87
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
TM|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|ION|ION_CONC
21
ARTICLE
Crystal structures of mutants of Thermus thermophilus IPMDH adapted to low temperatures.
2,001
10.1093/protein/14.2.81
11297665
Protein Eng;14;81-4
5
Hirose R|Suzuki T|Moriyama H|Sato T|Yamagishi A
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"ammonium sulfate","type":"ION"},{"numValue":null,"strValue":"1.0-1.5 M","ty...
[{"datasets":[],"id":80028,"numValue":87.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":80029,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
fireprotdb:8240
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,240
train
sequence
146
146
-1
345
-1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
0
0
0
0
-1
null
null
false
false
null
null
22,336
ProTherm
7
CD
Thermal
phosphate
20 mM
null
87
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
TM|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
57
ARTICLE
Analysis of the effect of accumulation of amino acid replacements on activity of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
2,001
10.1093/protein/14.8.601
11579229
Protein Eng;14;601-7
4
Suzuki T|Yamagishi A|Yasugi M|Oshima T
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":80652,"numValue":87.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":80653,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
fireprotdb:8241
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,241
train
sequence
146
146
-1
345
-1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
0
0
0
0
-1
null
null
false
false
null
null
22,396
ProTherm
7
Fluorescence
Thermal
potassium phosphate
50 mM
null
DTT
1 mM
30.85
null
null
null
null
1.73
15.8
null
null
null
null
null
null
null
null
null
yes
TM|DCP|DHVH|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|ION|ION_CONC
1593
ARTICLE
High thermal stability of 3-isopropylmalate dehydrogenase from Thermus thermophilus resulting from low DeltaC(p) of unfolding.
2,001
10.1093/protein/14.12.961
11809926
Protein Eng;14;961-6
3
Yamagishi A|Oshima T|Motono C
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Fluorescence","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"50 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"DTT"...
[{"datasets":[],"id":80812,"numValue":30.85,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":80813,"numValue":1.73,"references":[],"strValue":null,"type":"DCP"},{"datasets":[],"id":80814,"numValue":15.8,"references":[],"strValue":null,"type":"DHVH"},{"datasets":[],"id":80815,"numValue":null,"references"...
fireprotdb:8242
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,242
train
sequence
146
146
-1
345
-1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
0
0
0
0
-1
null
null
false
false
null
null
22,464
ProTherm
10.4
CD
Thermal
NaHCO3
20 mM
null
87
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
TM|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
128
ARTICLE
Cold-adaptation mechanism of mutant enzymes of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
2,002
10.1093/protein/15.6.471
12082165
Protein Eng;15;471-6
5
Suzuki Toshiharu|Yasugi Masako|Arisaka Fumio|Oshima Tairo|Yamagishi Akihiko
[{"numValue":10.4,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"NaHCO3","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":81023,"numValue":87.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":81024,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
fireprotdb:8243
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,243
train
sequence
146
146
-1
345
-1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
0
0
0
0
-1
null
null
false
false
null
null
23,021
ProTherm
7.6
Activity
Thermal
potassium phosphate
20 mM
null
84.7
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
No
TM|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
196
ARTICLE
Designing thermostable proteins: ancestral mutants of 3-isopropylmalate dehydrogenase designed by using a phylogenetic tree.
2,006
10.1016/j.jmb.2005.10.011
16309701
J Mol Biol;355;664-74
4
Yamagishi Akihiko|Ohkuri Takatoshi|Watanabe Keiko|Yokobori Shin-ichi
[{"numValue":7.6,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Activity","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":82684,"numValue":84.7,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":82685,"numValue":null,"references":[],"strValue":"No","type":"REVERSIBILITY"}]
fireprotdb:8244
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,244
train
sequence
146
146
-1
345
-1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
0
0
0
0
-1
null
null
false
false
null
null
23,022
ProTherm
7.6
CD
Thermal
phosphate
20 mM
null
87.4
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
No
TM|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC
196
ARTICLE
Designing thermostable proteins: ancestral mutants of 3-isopropylmalate dehydrogenase designed by using a phylogenetic tree.
2,006
10.1016/j.jmb.2005.10.011
16309701
J Mol Biol;355;664-74
4
Yamagishi Akihiko|Ohkuri Takatoshi|Watanabe Keiko|Yokobori Shin-ichi
[{"numValue":7.6,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"}]
[{"datasets":[],"id":82686,"numValue":87.4,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":82687,"numValue":null,"references":[],"strValue":"No","type":"REVERSIBILITY"}]
fireprotdb:8245
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,245
train
mutant
306
146
340
345
345
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
I11V
I11V
1
1
0
0
11
I
V
9
CONSERVATION
null
false
false
null
null
548
ProTherm
7
CD
Thermal
phosphate
20 mM
null
1OSI_A:I11V
91
4
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
57
ARTICLE
Analysis of the effect of accumulation of amino acid replacements on activity of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
2,001
10.1093/protein/14.8.601
11579229
Protein Eng;14;601-7
4
Suzuki T|Yamagishi A|Yasugi M|Oshima T
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1OSI_A:I11V","type":"_PD...
[{"datasets":[],"id":2180,"numValue":91.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":2181,"numValue":4.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":2182,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":8768,"numValue":9.0,"position":11,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8246
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,246
train
mutant
7,311
146
7,981
345
345
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
I11V|V15I
I11V|V15I
2
2
0
0
11
I
V
9
CONSERVATION
null
false
false
null
null
15,671
ProTherm
7
CD
Thermal
phosphate
20 mM
null
1OSI_A:I11V 1OSI_A:V15I
87
0
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
57
ARTICLE
Analysis of the effect of accumulation of amino acid replacements on activity of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
2,001
10.1093/protein/14.8.601
11579229
Protein Eng;14;601-7
4
Suzuki T|Yamagishi A|Yasugi M|Oshima T
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1OSI_A:I11V 1OSI_A:V15I"...
[{"datasets":[],"id":57513,"numValue":87.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":57514,"numValue":0.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":57515,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":8768,"numValue":9.0,"position":11,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8772,"numValue":8.0,"position":15,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8247
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,247
train
mutant
7,312
146
7,982
345
345
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
I11V|S92F
I11V|S92F
2
2
0
0
11
I
V
9
CONSERVATION
null
false
false
null
null
15,672
ProTherm
7
CD
Thermal
phosphate
20 mM
null
1OSI_A:I11V 1OSI_A:S92F
91
4
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
57
ARTICLE
Analysis of the effect of accumulation of amino acid replacements on activity of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
2,001
10.1093/protein/14.8.601
11579229
Protein Eng;14;601-7
4
Suzuki T|Yamagishi A|Yasugi M|Oshima T
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1OSI_A:I11V 1OSI_A:S92F"...
[{"datasets":[],"id":57516,"numValue":91.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":57517,"numValue":4.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":57518,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":8768,"numValue":9.0,"position":11,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8849,"numValue":2.0,"position":92,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8248
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,248
train
mutant
7,316
146
7,986
345
345
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
I11V|V15I|S92F
I11V|V15I|S92F
3
3
0
0
11
I
V
9
CONSERVATION
null
false
false
null
null
15,676
ProTherm
7
CD
Thermal
phosphate
20 mM
null
1OSI_A:I11V 1OSI_A:V15I 1OSI_A:S92F
85
-2
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
57
ARTICLE
Analysis of the effect of accumulation of amino acid replacements on activity of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
2,001
10.1093/protein/14.8.601
11579229
Protein Eng;14;601-7
4
Suzuki T|Yamagishi A|Yasugi M|Oshima T
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1OSI_A:I11V 1OSI_A:V15I ...
[{"datasets":[],"id":57528,"numValue":85.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":57529,"numValue":-2.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":57530,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":8768,"numValue":9.0,"position":11,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8772,"numValue":8.0,"position":15,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8849,"numValue":2.0,"position":92,"positionArray":null,"positionRange":...
fireprotdb:8249
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,249
train
mutant
129
146
147
345
345
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
V15I
V15I
1
1
0
0
15
V
I
8
CONSERVATION
null
false
false
null
null
241
ProTherm
7
CD
Thermal
sodium phosphate
null
ammonium sulfate
1.0-1.5 M
1OSI_A:V15I
85
null
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
TM|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|ION|ION_CONC|_PDB_CHAIN_MUTATION
21
ARTICLE
Crystal structures of mutants of Thermus thermophilus IPMDH adapted to low temperatures.
2,001
10.1093/protein/14.2.81
11297665
Protein Eng;14;81-4
5
Hirose R|Suzuki T|Moriyama H|Sato T|Yamagishi A
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"sodium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"ammonium sulfate","type":"ION"},{"numValue":null,"strValue":"1.0-1.5 M","ty...
[{"datasets":[],"id":992,"numValue":85.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":993,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":8772,"numValue":8.0,"position":15,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8250
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,250
train
mutant
129
146
147
345
345
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
V15I
V15I
1
1
0
0
15
V
I
8
CONSERVATION
null
false
false
null
null
549
ProTherm
7
CD
Thermal
phosphate
20 mM
null
1OSI_A:V15I
85
-2
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
57
ARTICLE
Analysis of the effect of accumulation of amino acid replacements on activity of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
2,001
10.1093/protein/14.8.601
11579229
Protein Eng;14;601-7
4
Suzuki T|Yamagishi A|Yasugi M|Oshima T
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1OSI_A:V15I","type":"_PD...
[{"datasets":[],"id":2183,"numValue":85.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":2184,"numValue":-2.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":2185,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":8772,"numValue":8.0,"position":15,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8251
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,251
train
mutant
7,313
146
7,983
345
345
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
V15I|S92F
V15I|S92F
2
2
0
0
15
V
I
8
CONSERVATION
null
false
false
null
null
15,673
ProTherm
7
CD
Thermal
phosphate
20 mM
null
1OSI_A:V15I 1OSI_A:S92F
83
-4
null
null
null
null
null
null
null
null
null
null
null
null
null
null
Unknown
TM|DTM|REVERSIBILITY
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
57
ARTICLE
Analysis of the effect of accumulation of amino acid replacements on activity of 3-isopropylmalate dehydrogenase from Thermus thermophilus.
2,001
10.1093/protein/14.8.601
11579229
Protein Eng;14;601-7
4
Suzuki T|Yamagishi A|Yasugi M|Oshima T
[{"numValue":7.0,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"CD","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1OSI_A:V15I 1OSI_A:S92F"...
[{"datasets":[],"id":57519,"numValue":83.0,"references":[],"strValue":null,"type":"TM"},{"datasets":[],"id":57520,"numValue":-4.0,"references":[],"strValue":null,"type":"DTM"},{"datasets":[],"id":57521,"numValue":null,"references":[],"strValue":"Unknown","type":"REVERSIBILITY"}]
[{"id":8772,"numValue":8.0,"position":15,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"},{"id":8849,"numValue":2.0,"position":92,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]
fireprotdb:8255
fireprotdb
LiteFold/FireProtDB
labeled/fireprotdb/fireprotdb_search_all.jsonl
tables/labeled_fireprotdb_fireprotdb_search_all.jsonl.jsonl
79354b4f8754e21c3eb41aaf3dd63ba34ae750cd
8,255
train
mutant
1,015
146
1,147
345
345
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
18
3-isopropylmalate dehydrogenase
Thermus thermophilus
1
P61495
IPR019818|IPR024084|IPR004429
1.1.1.85
F53L
F53L
1
1
0
0
53
F
L
6
CONSERVATION
null
false
false
null
null
1,811
ProTherm
7.6
Activity
Thermal
potassium phosphate
20 mM
null
1OSI_A:F53L
82.9
-1.8
null
null
null
null
null
null
null
null
null
null
null
null
null
null
No
TM|DTM|REVERSIBILITY
AUTOMUTE_S1925.csv|I_Mutant2.0_S1948.csv|I_Mutant2.0_S2087.csv|iPTREE-STAB_S1859.csv|M47andM8_S1810.csv|M47andM8_S2760.csv|Saraboji_S1396.csv|EASE-MM_S1676.csv|HotMuSiC_S1626.csv|PON-TStab_dataset.csv|PoPMuSiC-2.0_S2648.csv|STRUM_Q3421.csv|SVM-WIN31_SVM-3D12_S1634.csv|SVM-WIN31_SVM-3D12_S1681.csv
PH|MEASURE|METHOD|BUFFER|BUFFER_CONC|_PDB_CHAIN_MUTATION
196
ARTICLE
Designing thermostable proteins: ancestral mutants of 3-isopropylmalate dehydrogenase designed by using a phylogenetic tree.
2,006
10.1016/j.jmb.2005.10.011
16309701
J Mol Biol;355;664-74
4
Yamagishi Akihiko|Ohkuri Takatoshi|Watanabe Keiko|Yokobori Shin-ichi
[{"numValue":7.6,"strValue":null,"type":"PH"},{"numValue":null,"strValue":"Activity","type":"MEASURE"},{"numValue":null,"strValue":"Thermal","type":"METHOD"},{"numValue":null,"strValue":"potassium phosphate","type":"BUFFER"},{"numValue":null,"strValue":"20 mM","type":"BUFFER_CONC"},{"numValue":null,"strValue":"1OSI_A:F...
[{"datasets":["AUTOMUTE_S1925.csv","I_Mutant2.0_S1948.csv","I_Mutant2.0_S2087.csv","iPTREE-STAB_S1859.csv","M47andM8_S1810.csv","M47andM8_S2760.csv","Saraboji_S1396.csv"],"id":6727,"numValue":82.9,"references":[],"strValue":null,"type":"TM"},{"datasets":["AUTOMUTE_S1925.csv","EASE-MM_S1676.csv","HotMuSiC_S1626.csv","I_...
[{"id":8810,"numValue":6.0,"position":53,"positionArray":null,"positionRange":null,"strValue":null,"type":"CONSERVATION"}]