LiteFold/InterPro · Datasets at Hugging Face

IPR014212

14,212

RNA polymerase sigma-G type

RNA_pol_sigma-G

Family

1,708

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[ "GO:0003677", "GO:0003700", "GO:0016987", "GO:0006352", "GO:0006355" ]

[ "DNA binding", "DNA-binding transcription factor activity", "sigma factor activity", "DNA-templated transcription initiation", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "NCBIFAM" ]

[ "TIGR02850" ]

[ "spore_sigG" ]

[ 1708 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Plastid sigma factors: Their individual functions and regulation in transcription."...

[ 1988, 1992, 1986, 2015 ]

4

[ "IPR014322" ]

[]

1

0

1

[ "Bacillota", "ecological metagenomes" ]

[ 1701, 7 ]

2

[]

0

true

Family

RNA polymerase sigma-G type

RNA_pol_sigma-G

8

IPR014213

14,213

Sporulation stage V, protein T

SpoVT

Family

2,202

false

Members of this protein family are stage V sporulation protein T (SpoVT), a protein of the sporulation/germination program in Bacillus subtilis and related species. The amino-terminal 50 amino acids are nearly perfectly conserved across all endospore-forming bacteria. SpoVT is a DNA-binding transcriptional regulator re...

[]

0

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF026579", "TIGR02851" ]

[ "Spore_V_T", "spore_V_T" ]

[ 2197, 2173 ]

2

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "2w1t" ]

1

[ "PUB00009808" ]

[ "8755877" ]

[ "A compartmentalized regulator of developmental gene expression in Bacillus subtilis." ]

[ 1996 ]

1

[]

0

null

[ "Bacillota", "Phytophthora kernoviae 00238/432", "unclassified sequences" ]

[ 2189, 1, 12 ]

3

[]

0

true

Family

Sporulation stage V, protein T

SpoVT

6

IPR014214

14,214

Dipicolinic acid synthetase, subunit B

Dipicolinic_acid_synth_B

Family

1,870

false

Members of this entry represent the B subunit of dipicolinic acid synthetase, an enzyme that synthesizes a small molecule that appears to confer heat stability to bacterial endospores such as those of Bacillus subtilis. The A and B subunits are together in what was originally designated the spoVF locus for stage V of e...

[]

0

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF001390", "TIGR02852" ]

[ "Dipicolinate_synth_subunit_B", "spore_dpaB" ]

[ 1773, 1865 ]

2

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "3lqk", "3mcu" ]

2

[]

0

[]

0

null

[ "Bacillota", "ecological metagenomes" ]

[ 1863, 7 ]

2

[]

0

true

Family

Dipicolinic acid synthetase, subunit B

Dipicolinic_acid_synth_B

6

IPR014215

14,215

Dipicolinic acid synthetase subunit A

Dipicolinic_acid_synth_A

Family

1,384

false

This predicted Rossman fold-containing protein is the A subunit of dipicolinic acid synthetase as found in most, though not all, endospore-forming low-GC Gram-positive bacteria; it is absent in Clostridium. The B subunit is represented by . This protein is also known as SpoVFA.

[]

0

[ "NCBIFAM" ]

[ "TIGR02853" ]

[ "spore_dpaA" ]

[ 1384 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "2rir", "3d4o" ]

2

[]

0

[]

0

null

[ "Bacillota", "ecological metagenomes" ]

[ 1382, 2 ]

2

[]

0

true

Family

Dipicolinic acid synthetase subunit A

Dipicolinic_acid_synth_A

1

IPR014216

14,216

ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD

ABC_transptr_CydD

Family

10,601

false

The gene pair cydCD encodes an ABC-family transporter in which each gene contains an N-terminal membrane-spanning domain and a C-terminal ATP-binding domain [ ]. In Escherichia coli these genes were discovered as mutants which caused the terminal haem-copper oxidase complex cytochrome bd to fail to assemble. Recent wor...

[ "GO:0005524", "GO:0140359", "GO:0042883", "GO:0016020" ]

[ "ATP binding", "ABC-type transporter activity", "cysteine transport", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR02857" ]

[ "CydD" ]

[ 10601 ]

1

[ "EC", "GP", "METACYC", "METACYC" ]

[ "7.4.2.-", "GenProp0617", "PWY-6409", "PWY-8419" ]

[ "EC:7.4.2.-", "GP:GenProp0617", "METACYC:PWY-6409", "METACYC:PWY-8419" ]

4

[ "7zd5", "7zda", "7zdb", "7zdc", "7zde", "7zdf", "7zdg", "7zdk", "7zdl", "7zdr", "7zds", "7zdt", "7zdu", "7zdv", "7zdw", "7ze5", "7zec", "8ipq", "8ipr", "8ips", "8ipt" ]

21

[ "PUB00034412", "PUB00034413", "PUB00060946" ]

[ "16040611", "12393891", "15470119" ]

[ "A bacterial glutathione transporter (Escherichia coli CydDC) exports reductant to the periplasm.", "Cysteine is exported from the Escherichia coli cytoplasm by CydDC, an ATP-binding cassette-type transporter required for cytochrome assembly.", "Membrane topology and mutational analysis of Escherichia coli CydD...

[ 2005, 2002, 2004 ]

3

[ "IPR039421" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 10534, 8, 59 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD

ABC_transptr_CydD

8

IPR014217

14,217

Sporulation stage III, protein AA

Spore_III_AA

Family

2,250

false

Proteins in this entry include the stage III sporulation protein AA that is encoded by one of several genes in the spoIIIA locus. This protein is only found in species that are capable of endospore formation.

[]

0

[ "NCBIFAM" ]

[ "TIGR02858" ]

[ "spore_III_AA" ]

[ 2250 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[]

0

[]

0

null

[ "Bacillota", "Phytophthora kernoviae 00238/432", "ecological metagenomes" ]

[ 2243, 1, 6 ]

3

[]

0

true

Family

Sporulation stage III, protein AA

Spore_III_AA

5

IPR014218

14,218

RNA polymerase sigma-H type

RNA_pol_sigma-H

Family

2,146

false

Members of this entry represent the RNA polymerase sigma-H factor required for sporulation in endospore-forming bacteria. These proteins are also called Sigma-30 and SigH. Related sequences exist in Listeria, but as Listeria does not form spores the role of these related sigma factors in that genus is in doubt. The bac...

[ "GO:0003677", "GO:0003700", "GO:0016987", "GO:0006352", "GO:0006355" ]

[ "DNA binding", "DNA-binding transcription factor activity", "sigma factor activity", "DNA-templated transcription initiation", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "NCBIFAM" ]

[ "TIGR02859" ]

[ "spore_sigH" ]

[ 2146 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Plastid sigma factors: Their individual functions and regulation in transcription."...

[ 1988, 1992, 1986, 2015 ]

4

[ "IPR016371" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2131, 2, 13 ]

3

[]

0

true

Family

RNA polymerase sigma-H type

RNA_pol_sigma-H

4

IPR014219

14,219

SpoIVB peptidase

SpoIVB

Family

2,537

false

SpoIVB, the stage IV sporulation protein B of endospore-forming bacteria such as Bacillus subtilis, is a serine proteinase expressed in the spore (rather than mother cell) compartment, that participates in a proteolytic activation cascade for Sigma-K. It appears to be universal among endospore-forming bacteria and occu...

[]

0

[ "NCBIFAM" ]

[ "TIGR02860" ]

[ "spore_IV_B" ]

[ 2537 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "9lnf" ]

1

[ "PUB00000522", "PUB00003576" ]

[ "8439290", "7845208" ]

[ "Evolutionary families of peptidases.", "Families of serine peptidases." ]

[ 1993, 1994 ]

2

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2522, 15 ]

2

[]

0

true

Family

SpoIVB peptidase

SpoIVB

6

IPR014220

14,220

Small acid-soluble spore protein, SspJ

SASP_SspJ

Family

62

false

This entry represents a group of small acid-soluble proteins (SASP) from Bacillus species, which are present in spores but not in growing cells. The sspJ gene is transcribed in the forespore compartment by RNA polymerase with the forespore-specific sigmaG. Loss of SspJ causes a slight decrease in the rate of spore outg...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09575", "TIGR02863" ]

[ "Spore_SspJ", "spore_sspJ" ]

[ 62, 60 ]

2

[]

0

[]

0

[ "PUB00034414" ]

[ "9852018" ]

[ "New small, acid-soluble proteins unique to spores of Bacillus subtilis: identification of the coding genes and regulation and function of two of these genes." ]

[ 1998 ]

1

[]

0

null

[ "Bacillaceae" ]

[ 62 ]

1

[]

0

true

Family

Small acid-soluble spore protein, SspJ

SASP_SspJ

2

IPR014221

14,221

Stage II sporulation protein E

SpoII_E

Family

1,859

false

This entry contains the stage II sporulation protein E (SpoIIE, ), which is a multiple membrane spanning protein with two separable functions. It plays a role in the switch to polar cell division during sporulation and it has phosphatase activity, located in the C-terminal region, which is required to activate sigma-F ...

[ "GO:0004722" ]

[ "protein serine/threonine phosphatase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR02865" ]

[ "spore_II_E" ]

[ 1859 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "5ucg" ]

1

[ "PUB00098969" ]

[ "28527238" ]

[ "A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases." ]

[ 2017 ]

1

[]

0

null

[ "Bacillota", "Phytophthora kernoviae 00238/432", "metagenomes" ]

[ 1851, 1, 7 ]

3

[]

0

true

Family

Stage II sporulation protein E

SpoII_E

8

IPR014222

14,222

Cytochrome c oxidase, subunit II

Cyt_c_oxidase_su2

Domain

49,524

false

This entry contains subunit II (CoxB) of cytochrome c oxidase. Cytochrome c oxidase is the terminal electron acceptor of mitochondria (and one of several possible acceptors in prokaryotes) in the electron transport chain of aerobic respiration. The enzyme couples the oxidation of reduced cytochrome c to the reduction o...

[ "GO:0016491", "GO:0016020" ]

[ "oxidoreductase activity", "membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "NCBIFAM" ]

[ "TIGR02866" ]

[ "CoxB" ]

[ 49524 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "7.1.1.9", "GenProp0614", "PWY-3781", "PWY-4521", "PWY-6692", "PWY-7279", "PWY-7429", "PWY-8271", "R-BTA-5419276", "R-BTA-5628897", "R-BTA-611105", "R-BTA-9707564", "R-BTA-9864848", "R-DDI-9837999", "R-DME-5419276", "R-DME-5628897", "R-DME-611105", "R-DME-9707564", "R-DME-9864848...

[ "EC:7.1.1.9", "GP:GenProp0614", "METACYC:PWY-3781", "METACYC:PWY-4521", "METACYC:PWY-6692", "METACYC:PWY-7279", "METACYC:PWY-7429", "METACYC:PWY-8271", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-5628897", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-9707564", "REACTOME:R-BTA-9864848", "REACTOME...

44

[ "1ar1", "1m56", "1m57", "1occ", "1oco", "1ocr", "1ocz", "1qle", "1v54", "1v55", "2dyr", "2dys", "2eij", "2eik", "2eil", "2eim", "2ein", "2gsm", "2occ", "2y69", "2ybb", "2yev", "2zxw", "3abk", "3abl", "3abm", "3ag1", "3ag2", "3ag3", "3ag4", "3asn", "3aso"...

156

[ "PUB00034415" ]

[ "9380672" ]

[ "Structure at 2.7 A resolution of the Paracoccus denitrificans two-subunit cytochrome c oxidase complexed with an antibody FV fragment." ]

[ 1997 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 560, 14405, 34219, 340 ]

4

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "...

[ 3, 2, 7, 420, 3, 1, 3, 6, 1, 1, 2 ]

11

true

Domain

Cytochrome c oxidase, subunit II

Cyt_c_oxidase_su2

6

IPR014223

14,223

Glutathione/L-cysteine transport system ATP-binding/permease protein CydC/D

ABC_CydC/D

Family

10,686

false

This entry represents the glutathione/L-cysteine transport system ATP-binding/permease protein CydC, a member of a heterodimeric ATP-binding cassette-type transporter (ABC transporter). It is involved in the export of glutathione from the cytoplasm to the periplasm and is required for the assembly of both cytochrome c ...

[ "GO:0042626", "GO:0034775", "GO:0045454", "GO:0016020" ]

[ "ATPase-coupled transmembrane transporter activity", "glutathione transmembrane transport", "cell redox homeostasis", "membrane" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR02868" ]

[ "CydC" ]

[ 10686 ]

1

[ "EC", "GP", "METACYC", "METACYC" ]

[ "7.4.2.-", "GenProp0617", "PWY-6409", "PWY-8419" ]

[ "EC:7.4.2.-", "GP:GenProp0617", "METACYC:PWY-6409", "METACYC:PWY-8419" ]

4

[ "7zd5", "7zda", "7zdb", "7zdc", "7zde", "7zdf", "7zdg", "7zdk", "7zdl", "7zdr", "7zds", "7zdt", "7zdu", "7zdv", "7zdw", "7ze5", "7zec", "8ips", "8ipt" ]

19

[ "PUB00004290", "PUB00014769", "PUB00017894", "PUB00017895", "PUB00017896", "PUB00017897", "PUB00017898", "PUB00017899", "PUB00025109", "PUB00026406", "PUB00034412", "PUB00034413", "PUB00034416", "PUB00043654", "PUB00087496", "PUB00103852" ]

[ "9872322", "9873074", "11421269", "1282354", "9640644", "11988180", "11470432", "11402022", "11080142", "11532960", "16040611", "12393891", "9335308", "11421270", "9852001", "24958725" ]

[ "Crystal structure of the ATP-binding subunit of an ABC transporter.", "Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.", "ABC transporters: physiology, structure and mechanism--an overview.", "ABC transporters: from microorgani...

[ 1998, 1999, 2001, 1992, 1998, 2002, 2001, 2001, 2000, 2001, 2005, 2002, 1997, 2001, 1998, 2014 ]

16

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "unclassified sequences" ]

[ 10593, 8, 5, 80 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Glutathione/L-cysteine transport system ATP-binding/permease protein CydC/D

ABC_CydC/D

6

IPR014224

14,224

Spore cortex-lytic enzyme SleB

Spore_cortex_SleB

Family

2,074

false

The entry represents the spore cortex-lytic enzyme SleB from Bacillus subtilis and other Gram-positive, endospore-forming bacterial species. SleB is stored in an inactive form in the spore and activated during germination.

[ "GO:0003824", "GO:0009847" ]

[ "catalytic activity", "spore germination" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR02869" ]

[ "spore_SleB" ]

[ 2074 ]

1

[]

0

[ "4fet" ]

1

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 2070, 4 ]

2

[]

0

true

Family

Spore cortex-lytic enzyme SleB

Spore_cortex_SleB

3

IPR014225

14,225

Sporulation stage II, protein D firmicutes

Spore_II_D_firmicutes

Family

2,286

false

This entry contains the stage II sporulation protein D (SpoIID), which is a protein involved in the endospore formation program. SpoIID is one of the three genes (spoIID, spoIIM and spoIIP, [ , , ]), under the control of sigma E, that have been shown to be essential for the engulfment of the forespore by the mother cel...

[]

0

[ "NCBIFAM" ]

[ "TIGR02870" ]

[ "spore_II_D" ]

[ 2286 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "4rwr", "5i1t", "5txu" ]

3

[ "PUB00012907", "PUB00034447", "PUB00034448", "PUB00034449" ]

[ "12662922", "8501064", "7836306", "3011962" ]

[ "The sigmaE regulon and the identification of additional sporulation genes in Bacillus subtilis.", "Physical and functional characterization of the Bacillus subtilis spoIIM gene.", "Identification and characterization of the Bacillus subtilis spoIIP locus.", "spoIID operon of Bacillus subtilis: cloning and se...

[ 2003, 1993, 1995, 1986 ]

4

[ "IPR013486" ]

[]

1

0

1

[ "Bacteria", "Pseudomonas phage PPA5", "metagenomes" ]

[ 2271, 1, 14 ]

3

[]

0

true

Family

Sporulation stage II, protein D firmicutes

Spore_II_D_firmicutes

1

IPR014227

14,227

Putative transport protein YtvI-like

YtvI-like

Family

3,394

false

This family includes transport proteins such as sodium-lithium/proton antiporter from Halobacillus [ ] and sporulation protein YtvI from Bacillus subtilis, a putative permease [ ]. YtvI has extensive hydrophobic regions and is likely to be an integral membrane protein.

[]

0

[ "NCBIFAM" ]

[ "TIGR02872" ]

[ "spore_ytvI" ]

[ 3394 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[ "PUB00012907", "PUB00086646" ]

[ "12662922", "28374790" ]

[ "The sigmaE regulon and the identification of additional sporulation genes in Bacillus subtilis.", "A UPF0118 family protein with uncharacterized function from the moderate halophile Halobacillus andaensis represents a novel class of Na+(Li+)/H+ antiporter." ]

[ 2003, 2017 ]

2

[ "IPR002549" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 3380, 14 ]

2

[]

0

true

Family

Putative transport protein YtvI-like

YtvI-like

2

IPR014229

14,229

Spore protein GerW

GerW

Family

3,982

false

This entry represents spore protein GerW, a protein associated with dormant spore biology. GerW may contribute to the maintenance or characteristics of dormant spores; however, it does not appear to play a role in spore germination, suggesting its function is specific to the dormant state rather than the transition to ...

[]

0

[ "PFAM", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "PF09579", "PIRSF021377", "PTHR39162", "TIGR02874" ]

[ "Spore_YtfJ", "YtfJ", "", "spore_ytfJ" ]

[ 3974, 2827, 3495, 2278 ]

4

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[ "PUB00034417", "PUB00106718" ]

[ "12480901", "25790435" ]

[ "Proteomics characterization of novel spore proteins of Bacillus subtilis.", "The GerW protein is not involved in the germination of spores of Bacillus species." ]

[ 2002, 2015 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctf8W5", "metagenomes" ]

[ 195, 3721, 4, 1, 61 ]

5

[]

0

true

Family

Spore protein GerW

GerW

7

IPR014230

14,230

Sporulation protein YhbH

Spore_YhbH

Family

1,679

false

Proteins in this entry, typified by YhbH from Bacillus subtilis, are found in the genomes of nearly every endospore-forming bacterium, and in no other genomes. The gene in B. subtilis was shown to be a member of the sigma-E regulon, with mutation leading to a sporulation defect [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR02877" ]

[ "spore_yhbH" ]

[ 1679 ]

1

[]

0

[]

0

[ "PUB00012907" ]

[ "12662922" ]

[ "The sigmaE regulon and the identification of additional sporulation genes in Bacillus subtilis." ]

[ 2003 ]

1

[ "IPR006698" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 1676, 3 ]

2

[]

0

true

Family

Sporulation protein YhbH

Spore_YhbH

6

IPR014231

14,231

Sporulation protein YpjB

Spore_YpjB

Family

1,254

false

Proteins in thie entry, typified by YpjB, are restricted to a subset of the endospore-forming bacteria which includes Bacillus species, but not species. In Bacillus subtilis, ypjB was found to be part of the sigma-E regulon [ ]. Sigma-E is a sporulation sigma factor that regulates expression in the mother cell compartm...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09577", "TIGR02878" ]

[ "Spore_YpjB", "spore_ypjB" ]

[ 1254, 541 ]

2

[]

0

[]

0

[ "PUB00012907" ]

[ "12662922" ]

[ "The sigmaE regulon and the identification of additional sporulation genes in Bacillus subtilis." ]

[ 2003 ]

1

[]

0

null

[ "Bacillota" ]

[ 1254 ]

1

[]

0

true

Family

Sporulation protein YpjB

Spore_YpjB

3

IPR014232

14,232

Sporulation stage V, protein K

Spore_V_K

Family

768

false

Proteins in this entry include the stage V sporulation protein K (SpoVK), a close homologue of the Rubisco expression protein CbbX ( ), and are members of an ATPase family associated with various cellular activities. These proteins are strictly limited to bacterial endospore-forming species, but are not found universal...

[]

0

[ "NCBIFAM" ]

[ "TIGR02881" ]

[ "spore_V_K" ]

[ 768 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[]

0

[ "IPR000641" ]

[]

1

0

1

[ "Bacillota", "bioreactor metagenome" ]

[ 767, 1 ]

2

[]

0

true

Family

Sporulation stage V, protein K

Spore_V_K

1

IPR014233

14,233

Quinol oxidase subunit I

QoxB

Family

1,260

false

This entry represents subunit I of the aa3-type quinone oxidase, one of several terminal oxidases found in bacteria [ ]. This complex couples the oxidation of reduced quinones to the reduction of molecular oxygen to water, and the pumping of protons to form a proton gradient utilised for ATP production. aa3-type oxidas...

[ "GO:0005507", "GO:0016682", "GO:0020037", "GO:0016020" ]

[ "copper ion binding", "oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor", "heme binding", "membrane" ]

[ "molecular_function", "molecular_function", "molecular_function", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR02882" ]

[ "QoxB" ]

[ 1260 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.10.3.-", "GenProp0620", "PWY-5399", "PWY-5404", "PWY-5439", "PWY-5476", "PWY-5780", "PWY-5787", "PWY-7079" ]

[ "EC:1.10.3.-", "GP:GenProp0620", "METACYC:PWY-5399", "METACYC:PWY-5404", "METACYC:PWY-5439", "METACYC:PWY-5476", "METACYC:PWY-5780", "METACYC:PWY-5787", "METACYC:PWY-7079" ]

9

[ "6kob", "6koc", "6koe" ]

3

[ "PUB00034418" ]

[ "7575098" ]

[ "Properties of the menaquinol oxidase (Qox) and of qox deletion mutants of Bacillus subtilis." ]

[ 1995 ]

1

[ "IPR000883" ]

[]

1

0

1

[ "Bacillales", "human gut metagenome" ]

[ 1259, 1 ]

2

[]

0

true

Family

Quinol oxidase subunit I

QoxB

2

IPR014235

14,235

Peptidoglycan-N-acetylmuramic acid deacetylase PdaA

Spore_PdaA

Family

1,945

false

Muramic delta-lactam is an unusual constituent of peptidoglycan, found only in bacterial spores, in the peptidoglycan wall or spore cortex. This entry represents a subset of the larger polysaccharide deacetylase family that is specifically involved in delta-lactam biosynthesis. PdaA from Bacillus subtilis acts immediat...

[]

0

[ "NCBIFAM", "CDD" ]

[ "TIGR02884", "cd10948" ]

[ "spore_pdaA", "CE4_BsPdaA_like" ]

[ 1705, 1928 ]

2

[]

0

[ "1ny1", "1w17", "1w1a", "1w1b", "2j13" ]

5

[ "PUB00034579", "PUB00034580" ]

[ "14679227", "12374835" ]

[ "Production of muramic delta-lactam in Bacillus subtilis spore peptidoglycan.", "A polysaccharide deacetylase gene (pdaA) is required for germination and for production of muramic delta-lactam residues in the spore cortex of Bacillus subtilis." ]

[ 2004, 2002 ]

2

[ "IPR050248" ]

[]

1

0

1

[ "Bacteria", "Phytophthora kernoviae 00238/432", "ecological metagenomes" ]

[ 1939, 1, 5 ]

3

[]

0

true

Family

Peptidoglycan-N-acetylmuramic acid deacetylase PdaA

Spore_PdaA

2

IPR014236

14,236

RNA polymerase sigma-F type

RNA_pol_sigma-F

Family

1,833

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[ "GO:0003677", "GO:0003700", "GO:0016987", "GO:0006352", "GO:0006355" ]

[ "DNA binding", "DNA-binding transcription factor activity", "sigma factor activity", "DNA-templated transcription initiation", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "NCBIFAM" ]

[ "TIGR02885" ]

[ "spore_sigF" ]

[ 1833 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "1l0o" ]

1

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Plastid sigma factors: Their individual functions and regulation in transcription."...

[ 1988, 1992, 1986, 2015 ]

4

[ "IPR014322" ]

[]

1

0

1

[ "Bacillota", "Phytophthora kernoviae 00238/432", "metagenomes" ]

[ 1828, 1, 4 ]

3

[]

0

true

Family

RNA polymerase sigma-F type

RNA_pol_sigma-F

6

IPR014237

14,237

Anti-sigma F factor antagonist

Anti-sigma_F_ant

Family

1,763

false

This represents the anti-sigma F factor antagonist, also known as stage II sporulation protein AA. This protein is universally conserved in the endospore-forming bacteria, all of which belong to the Firmcutes.

[ "GO:0045152", "GO:0006355", "GO:0030435" ]

[ "antisigma factor binding", "regulation of DNA-templated transcription", "sporulation resulting in formation of a cellular spore" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR02886" ]

[ "spore_II_AA" ]

[ 1763 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "1auz", "1buz", "1h4x", "1h4y", "1h4z", "1th8", "1thn", "1tid", "1til" ]

9

[]

0

[ "IPR003658" ]

[]

1

0

1

[ "Bacillati", "metagenomes" ]

[ 1756, 7 ]

2

[]

0

true

Family

Anti-sigma F factor antagonist

Anti-sigma_F_ant

4

IPR014239

14,239

Sporulation protein YpeB, PepSY1 and PepSY2 domains

YpeB_PepSY1-2

Domain

2,001

false

Proteins in this entry include the sporulation protein YpeB from Bacillus subtilis. YpeB and the spore-cortex-lytic enzyme SleB are required for normal germination [ ]. These proteins are restricted to endospore-forming species in the Firmicutes lineage of bacteria, and have been found in all such species to date excep...

[ "GO:0009847" ]

[ "spore germination" ]

[ "biological_process" ]

1

[ "PFAM", "NCBIFAM" ]

[ "PF14620", "TIGR02889" ]

[ "YPEB_PepSY1-2", "spore_YpeB" ]

[ 2001, 1711 ]

2

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "5boi" ]

1

[ "PUB00100161", "PUB00151941", "PUB00151942", "PUB00151943" ]

[ "26219275", "16771673", "16905870", "21112786" ]

[ "Crystal structure of the PepSY-containing domain of the YpeB protein involved in germination of bacillus spores.", "Role of membrane-bound thiol-disulfide oxidoreductases in endospore-forming bacteria.", "Subcellular localization of a germiantion-specific cortex-lytic enzyme, SleB, of Bacilli during sporulatio...

[ 2015, 2006, 2006, 2011 ]

4

[]

0

null

[ "Bacteria", "Phytophthora kernoviae 00238/432", "metagenomes" ]

[ 1990, 1, 10 ]

3

[]

0

true

Domain

Sporulation protein YpeB, PepSY1 and PepSY2 domains

YpeB_PepSY1-2

5

IPR014240

14,240

Regulatory protein, YteA family

YteA

Family

2,021

false

This entry contains predicted regulatory proteins that are found in nearly every species of the endospore-forming bacteria within the Firmicutes (low-GC Gram-positive bacteria), with the exception of Clostridium perfringens. Some (but not all) of these proteins contain an unusual DksA/TraR C4-type zinc finger, where on...

[]

0

[ "NCBIFAM" ]

[ "TIGR02890" ]

[ "bacill_yteA" ]

[ 2021 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Arabidopsis thaliana", "Bacillota", "ecological metagenomes" ]

[ 1, 2016, 4 ]

3

[ "Arabidopsis thaliana" ]

[ 1 ]

1

true

Family

Regulatory protein, YteA family

YteA

5

IPR014241

14,241

Cytochrome c oxidase, subunit I bacterial type

Cyt_c_oxidase_su1_bac

Family

20,676

false

This entry represents the bacterial-type cytochrome c oxidase subunit I (CtaD, CoxA, CaaA). Cytochrome c oxidase is the component of the respiratory chain that catalyses the reduction of oxygen to water. Subunits I, II and III form the functional core of the enzyme complex. Subunit I is the catalytic subunit of the enz...

[ "GO:0004129", "GO:0015990" ]

[ "cytochrome-c oxidase activity", "electron transport coupled proton transport" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR02891" ]

[ "CtaD_CoxA" ]

[ 20676 ]

1

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "7.1.1.9", "GenProp0614", "GenProp1637", "PWY-3781", "PWY-4521", "PWY-6692", "PWY-7279", "PWY-7429", "PWY-8271" ]

[ "EC:7.1.1.9", "GP:GenProp0614", "GP:GenProp1637", "METACYC:PWY-3781", "METACYC:PWY-4521", "METACYC:PWY-6692", "METACYC:PWY-7279", "METACYC:PWY-7429", "METACYC:PWY-8271" ]

9

[ "1ar1", "1m56", "1m57", "1qle", "2gsm", "2yev", "3dtu", "3ehb", "3fye", "3fyi", "3hb3", "5weh", "6adq", "6hwh", "6pw0", "7ate", "7atn", "7au3", "7au6", "7e1v", "7e1w", "7e1x", "7jro", "7jrp", "7q21", "7qhm", "7qho", "7rh5", "7rh6", "7rh7", "8hcr", "8ovc"...

37

[]

0

[ "IPR000883" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 18804, 1563, 71, 238 ]

4

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 1, 4, 3 ]

3

true

Family

Cytochrome c oxidase, subunit I bacterial type

Cyt_c_oxidase_su1_bac

7

IPR014243

14,243

Prespore-specific transcriptional regulator RsfA-like

RsfA-like

Family

2,928

false

This entry represents a set of transcription factors found in some endospore-forming bacteria within the Firmicutes (low-GC Gram-positive bacteria), including Prespore-specific transcriptional regulator RsfA and Sporulation-specific transcriptional regulator GerR from Bacillus subtilis. In some species these proteins a...

[]

0

[ "PANTHER", "NCBIFAM" ]

[ "PTHR41302", "TIGR02894" ]

[ "", "DNA_bind_RsfA" ]

[ 2928, 2581 ]

2

[]

0

[]

0

[ "PUB00034503", "PUB00104934", "PUB00104935" ]

[ "10629188", "15621419", "20435725" ]

[ "Identification and characterization of a new prespore-specific regulatory gene, rsfA, of Bacillus subtilis.", "The ylbO gene product of Bacillus subtilis is involved in the coat development and lysozyme resistance of spore.", "Direct and indirect control of late sporulation genes by GerR of Bacillus subtilis."...

[ 2000, 2005, 2010 ]

3

[]

0

null

[ "Bacillota", "Caudoviricetes", "Rhizophagus irregularis" ]

[ 2918, 8, 2 ]

3

[]

0

true

Family

Prespore-specific transcriptional regulator RsfA-like

RsfA-like

1

IPR014245

14,245

Sporulation stage III, protein AF

Spore_III_AF

Family

2,371

false

This family represents the stage III sporulation protein AF (SpoIIIAF) of the bacterial endospore formation program, which exists in some but not all members of the Firmicutes (formerly called low-GC Gram-positives). These proteins have the typical RBM fold conserved in T3SS/flagellar systems [1]. The RBM fold of SpoII...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09581", "TIGR02896" ]

[ "Spore_III_AF", "spore_III_AF" ]

[ 2371, 1657 ]

2

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "6dcs" ]

1

[ "PUB00155401" ]

[ "29886194" ]

[ "Structural and biochemical characterization of SpoIIIAF, a component of a sporulation-essential channel in Bacillus subtilis." ]

[ 2018 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 2364, 7 ]

2

[]

0

true

Family

Sporulation stage III, protein AF

Spore_III_AF

9

IPR014247

14,247

Sporulation lipoprotein YhcN/YlaJ

Spore_lipoprot_YhcN/YlaJ

Family

1,910

false

This entry contains YhcN and YlaJ, which are predicted lipoproteins that have been detected as spore proteins but not vegetative proteins in Bacillus subtilis [ , ]. YlaJ and YhcN contribute to the efficiency of spore germination in Bacillus subtilis [ ]. Both appear to be expressed under control of the RNA polymerase ...

[ "GO:0030435" ]

[ "sporulation resulting in formation of a cellular spore" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "TIGR02898" ]

[ "spore_YhcN_YlaJ" ]

[ 1910 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "7peg" ]

1

[ "PUB00034417", "PUB00034581", "PUB00089808" ]

[ "12480901", "9611260", "28333204" ]

[ "Proteomics characterization of novel spore proteins of Bacillus subtilis.", "Characterization of yhcN, a new forespore-specific gene of Bacillus subtilis.", "Proteins YlaJ and YhcN contribute to the efficiency of spore germination in Bacillus subtilis." ]

[ 2002, 1998, 2017 ]

3

[ "IPR019076" ]

[]

1

0

1

[ "Bacillota" ]

[ 1910 ]

1

[]

0

true

Family

Sporulation lipoprotein YhcN/YlaJ

Spore_lipoprot_YhcN/YlaJ

4

IPR014248

14,248

Spore coat assembly protein SafA

Spore_coat_assembly_SafA

Domain

1,309

false

This entry represents a subset of the LysM domain of about 40 residues long which is found in a variety of enzymes involved in bacterial cell wall degradation [ ], and which may have a general peptidoglycan binding function. Proteins containing this domain include SafA of Bacillus subtilis, which is a protein found at ...

[]

0

[ "NCBIFAM" ]

[ "TIGR02899" ]

[ "spore_safA" ]

[ 1309 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "7r1l" ]

1

[ "PUB00001727" ]

[ "1352512" ]

[ "Modular design of the Enterococcus hirae muramidase-2 and Streptococcus faecalis autolysin." ]

[ 1992 ]

1

[ "IPR018392" ]

[]

1

0

1

[ "Bacteria", "Myoviridae sp. ctPGO22", "Opisthokonta", "bioreactor metagenome" ]

[ 1290, 1, 15, 3 ]

4

[]

0

true

Domain

Spore coat assembly protein SafA

Spore_coat_assembly_SafA

2

IPR014249

14,249

Sporulation stage V protein B

Spore_V_B

Family

1,807

false

This entry represents SpoVB, which is the stage V sporulation protein B of the bacterial endospore formation program in Bacillus subtilis and various other Firmcutes [ ]. It is nearly universal among endospore-formers. Paralogs with high sequence similarity to SpoVB exist, such as YkvU from B. subtilis and a number Clo...

[]

0

[ "NCBIFAM" ]

[ "TIGR02900" ]

[ "spore_V_B" ]

[ 1807 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[ "PUB00005697" ]

[ "1744050" ]

[ "Cloning, characterization, and expression of the spoVB gene of Bacillus subtilis." ]

[ 1991 ]

1

[ "IPR024923" ]

[]

1

0

1

[ "Bacillati", "ecological metagenomes" ]

[ 1804, 3 ]

2

[]

0

true

Family

Sporulation stage V protein B

Spore_V_B

3

IPR014250

14,250

Quinol oxidase subunit IV

QoxD

Family

1,168

false

This entry represents subunit IV of the aa3-type quinone oxidase (QoxD), one of several bacterial terminal oxidases [ ]. This complex couples oxidation of reduced quinones to the reduction of molecular oxygen to water, and the pumping of protons to form a proton gradient utilised for ATP production. aa3-type oxidases c...

[ "GO:0016682", "GO:0042773", "GO:0016020" ]

[ "oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor", "ATP synthesis coupled electron transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR02901" ]

[ "QoxD" ]

[ 1168 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.10.3.-", "GenProp0620", "PWY-5399", "PWY-5404", "PWY-5439", "PWY-5476", "PWY-5780", "PWY-5787", "PWY-7079" ]

[ "EC:1.10.3.-", "GP:GenProp0620", "METACYC:PWY-5399", "METACYC:PWY-5404", "METACYC:PWY-5439", "METACYC:PWY-5476", "METACYC:PWY-5780", "METACYC:PWY-5787", "METACYC:PWY-7079" ]

9

[]

0

[ "PUB00034418" ]

[ "7575098" ]

[ "Properties of the menaquinol oxidase (Qox) and of qox deletion mutants of Bacillus subtilis." ]

[ 1995 ]

1

[ "IPR005171" ]

[]

1

0

1

[ "Bacillales", "human gut metagenome" ]

[ 1167, 1 ]

2

[]

0

true

Family

Quinol oxidase subunit IV

QoxD

2

IPR014251

14,251

Sporulation protease LonB

Spore_LonB

Family

1,574

false

This entry represents LonB, a paralog of the ATP-dependent protease La (LonA, ). LonB proteins are unassigned peptidases belonging to the MEROPS peptidase family S16 (lon protease family, clan SJ) and are found strictly, and almost universally, in endospore-forming bacteria. This protease was shown, in Bacillus subtili...

[]

0

[ "NCBIFAM" ]

[ "TIGR02902" ]

[ "spore_lonB" ]

[ 1574 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[ "PUB00034583", "PUB00034584" ]

[ "11325926", "10411757" ]

[ "Forespore-specific transcription of the lonB gene during sporulation in Bacillus subtilis.", "Role of lon and ClpX in the post-translational regulation of a sigma subunit of RNA polymerase required for cellular differentiation in Bacillus subtilis." ]

[ 2001, 1999 ]

2

[ "IPR027065" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 1570, 4 ]

2

[]

0

true

Family

Sporulation protease LonB

Spore_LonB

8

IPR014252

14,252

Sporulation protease LonC

Spore_LonC

Family

463

false

Members of this protein family resemble the widely distributed ATP-dependent protease La, also called Lon and LonA. They resemble even more closely LonB, which is a LonA paralog found in genomes of species capable of endospore formation (such as Bacillus subtilis, Clostridium tetani, and select other members of the Fir...

[]

0

[ "NCBIFAM" ]

[ "TIGR02903" ]

[ "spore_lon_C" ]

[ 463 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 457, 6 ]

2

[]

0

true

Family

Sporulation protease LonC

Spore_LonC

4

IPR014253

14,253

Spore coat protein YsxE

Spore_coat_YsxE

Family

629

false

Members of this entry, which includes the Bacillus subtilis protein YsxE, are found only in the family Bacillaceae, part of the the endospore-forming group within the Firmicutes. As a rule, the ysxE gene is found immediately downstream of spoVID, a gene necessary for spore coat assembly. The protein has been shown to b...

[]

0

[ "NCBIFAM" ]

[ "TIGR02904" ]

[ "spore_ysxE" ]

[ 629 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[]

0

[ "IPR047175" ]

[]

1

0

1

[ "Bacillales" ]

[ 629 ]

1

[]

0

true

Family

Spore coat protein YsxE

Spore_coat_YsxE

9

IPR014254

14,254

Spore coat putative kinase YutH

Spore_coat_YutH

Family

651

false

This entry, represented by the Bacillus subtilis protein. Proteins in this entry are homologous to CotS ( ). YutH, is found only in the family Bacillaceae, part of the endospore-forming group within the Firmicutes. YutH has been shown to be involved in spore coat assmebly [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR02905" ]

[ "spore_yutH" ]

[ 651 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[ "PUB00016405" ]

[ "15231775" ]

[ "Dynamic patterns of subcellular protein localization during spore coat morphogenesis in Bacillus subtilis." ]

[ 2004 ]

1

[ "IPR060743" ]

[]

1

0

1

[ "Bacillales" ]

[ 651 ]

1

[]

0

true

Family

Spore coat putative kinase YutH

Spore_coat_YutH

1

IPR014255

14,255

Spore coat protein CotS

Spore_coat_CotS

Family

1,815

false

Members of this entry include the spore coat proteins CotS and YtaA from Bacillus subtilis and, from other endospore-forming bacteria, homologues that are more closely related to these two than to the spore coat proteins YutH ( ) and YsxE ( ). The CotS family is more broadly distributed than YutH or YsxE, but still is ...

[]

0

[ "NCBIFAM" ]

[ "TIGR02906" ]

[ "spore_CotS" ]

[ 1815 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[ "2q83" ]

1

[]

0

[ "IPR047175" ]

[]

1

0

1

[ "Bacillota", "metagenomes" ]

[ 1807, 8 ]

2

[]

0

true

Family

Spore coat protein CotS

Spore_coat_CotS

6

IPR014256

14,256

Sporulation stage VI, protein D

Spore_VI_D

Family

657

false

This entry represents SpoVID, the stage VI sporulation protein D, which is restricted to endospore-forming bacteria, all of which are found among the Firmicutes. It is widely distributed but not quite universal in this group. Between well-conserved N-terminal and C-terminal domains is a poorly conserved, low-complexity...

[]

0

[ "NCBIFAM" ]

[ "TIGR02907" ]

[ "spore_VI_D" ]

[ 657 ]

1

[ "GP" ]

[ "GenProp0610" ]

[ "GP:GenProp0610" ]

1

[]

0

[]

0

[]

0

null

[ "Bacillales" ]

[ 657 ]

1

[]

0

true

Family

Sporulation stage VI, protein D

Spore_VI_D

4

IPR014257

14,257

Cytochrome c oxidase, subunit IV bacillaceae

Cyt_c_oxidase_su4_bacillaceae

Family

718

false

This entry represents a small clade of cytochrome oxidase subunit IV sequences found in the Bacillaceae.

[]

0

[ "NCBIFAM" ]

[ "TIGR02908" ]

[ "CoxD_Bacillus" ]

[ 718 ]

1

[]

0

[]

0

[]

0

[ "IPR005171" ]

[]

1

0

1

[ "Bacteria" ]

[ 718 ]

1

[]

0

true

Family

Cytochrome c oxidase, subunit IV bacillaceae

Cyt_c_oxidase_su4_bacillaceae

4

IPR014259

14,259

Sulphite reductase, subunit A

Sulphite_reductase_A

Family

1,376

false

This entry represents subunit A, one of the three subunits of the anaerobic sulphite reductase of Salmonella, and close homologues from various Clostridium species, where the three-gene neighbourhood is preserved. Two such gene clusters are found in Clostridium perfringens, but it may be that these sets of genes corres...

[]

0

[ "NCBIFAM" ]

[ "TIGR02910" ]

[ "sulfite_red_A" ]

[ 1376 ]

1

[ "GP" ]

[ "GenProp0624" ]

[ "GP:GenProp0624" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1372, 4 ]

2

[]

0

true

Family

Sulphite reductase, subunit A

Sulphite_reductase_A

2

IPR014260

14,260

Sulphite reductase, subunit B

Sulphite_reductase_B

Family

1,222

false

This entry represents subunit B, one of the three subunits of the anaerobic sulphite reductase of Salmonella, and close homologues from various Clostridium species, where the three-gene neighbourhood is preserved. Two such gene clusters are found in Clostridium perfringens, but it may be that these sets of genes corres...

[]

0

[ "NCBIFAM" ]

[ "TIGR02911" ]

[ "sulfite_red_B" ]

[ 1222 ]

1

[ "GP" ]

[ "GenProp0624" ]

[ "GP:GenProp0624" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1219, 3 ]

2

[]

0

true

Family

Sulphite reductase, subunit B

Sulphite_reductase_B

3

IPR014261

14,261

Sulphite reductase, subunit C

Sulphite_reductase_C

Family

1,192

false

This entry represents subunit C, one of the three subunits of the anaerobic sulphite reductase of Salmonella, and close homologues from various Clostridium species, where the three-gene neighbourhood is preserved. Two such gene clusters are found in Clostridium perfringens, but it may be that these sets of genes corres...

[]

0

[ "NCBIFAM" ]

[ "TIGR02912" ]

[ "sulfite_red_C" ]

[ 1192 ]

1

[ "GP" ]

[ "GenProp0624" ]

[ "GP:GenProp0624" ]

1

[]

0

[]

0

[ "IPR045169" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 1189, 3 ]

2

[]

0

true

Family

Sulphite reductase, subunit C

Sulphite_reductase_C

5

IPR014262

14,262

HAF repeat

HAF_rpt

Repeat

1,824

false

This repeat is approximately 40 amino acids in length and the spacing between repeats is usually is four residues. Proteins generally have a least two tandem copies, and can have as many as seven. This repeat is named after a conserved tripeptide motif, HAF, found in most of the proteins. Some proteins containing the r...

[]

0

[ "NCBIFAM" ]

[ "TIGR02913" ]

[ "HAF_rpt" ]

[ 1824 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "metagenomes" ]

[ 1776, 11, 9, 28 ]

4

[]

0

true

Repeat

HAF repeat

HAF_rpt

1

IPR014263

14,263

Methanolan biosynthesis EpsI

Methanolan_biosynth_EpsI

Domain

2,361

false

This entry represents a domain that covers the whole protein sequence in EpsI from Methylobacillus sp. 12S. EpsI is encoded immediately downstream of the multiple-membrane-spanning putative transporter EpsH, and is predicted to be a periplasmic protein involved in, but not required for, expression of the exopolysacchar...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF11984", "TIGR02914" ]

[ "DUF3485", "EpsI_fam" ]

[ 2361, 1961 ]

2

[ "GP", "GP" ]

[ "GenProp0326", "GenProp0652" ]

[ "GP:GenProp0326", "GP:GenProp0652" ]

2

[]

0

[ "PUB00021014" ]

[ "12624205" ]

[ "Genes involved in the synthesis of the exopolysaccharide methanolan by the obligate methylotroph Methylobacillus sp strain 12S." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanomicrobia", "ecological metagenomes" ]

[ 2289, 7, 13, 52 ]

4

[]

0

true

Domain

Methanolan biosynthesis EpsI

Methanolan_biosynth_EpsI

8

IPR014264

14,264

PEP-CTERM-box response regulator transcription factor

PEP-CTERM_resp_reg

Family

1,402

false

This entry represents a protein family that shares full-length homology with (but do not include) the acetoacetate metabolism regulatory protein AtoC (see ). These proteins have a Fis family DNA binding sequence, a response regulator receiver domain, and sigma-54 interaction domain. They are found strictly within a sub...

[]

0

[ "NCBIFAM" ]

[ "TIGR02915" ]

[ "PEP_resp_reg" ]

[ 1402 ]

1

[ "GP" ]

[ "GenProp0652" ]

[ "GP:GenProp0652" ]

1

[]

0

[ "PUB00010651", "PUB00011096", "PUB00034422", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807" ]

[ "12372152", "10966457", "16930487", "16176121", "18076326", "11934609", "11489844" ]

[ "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.", "Two-component signal transduct...

[ 2002, 2000, 2006, 2005, 2007, 2002, 2001 ]

7

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1369, 33 ]

2

[]

0

true

Family

PEP-CTERM-box response regulator transcription factor

PEP-CTERM_resp_reg

5

IPR014265

14,265

XrtA/PEP-CTERM system histidine kinase PrsK

XrtA/PrsK

Family

1,385

false

Proteins in this entry have a novel N-terminal domain, a single predicted membrane-spanning helix, and a predicted cytosolic histidine kinase domain. It was designated PrsK, and its companion DNA-binding response regulator protein ( ) PrsR. These predicted signal-transducing proteins appear to enable enhancer-dependent...

[]

0

[ "NCBIFAM" ]

[ "TIGR02916" ]

[ "PEP_his_kin" ]

[ 1385 ]

1

[ "GP" ]

[ "GenProp0652" ]

[ "GP:GenProp0652" ]

1

[]

0

[ "PUB00000966", "PUB00007866", "PUB00010651", "PUB00011096", "PUB00013246", "PUB00013247", "PUB00013562", "PUB00013563", "PUB00020801", "PUB00034422", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807", "PUB00105164" ]

[ "9989504", "11406410", "12372152", "10966457", "8868347", "10426948", "8029829", "1482126", "11145881", "16930487", "16176121", "18076326", "11934609", "11489844", "29473278" ]

[ "Structure of CheA, a signal-transducing histidine kinase.", "Histidine kinases and response regulator proteins in two-component signaling systems.", "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Protein aspartate phosphatases control...

[ 1999, 2001, 2002, 2000, 1996, 1999, 1994, 1992, 2000, 2006, 2005, 2007, 2002, 2001, 2018 ]

15

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1356, 29 ]

2

[]

0

true

Family

XrtA/PEP-CTERM system histidine kinase PrsK

XrtA/PrsK

1

IPR014266

14,266

PEP-CTERM system TPR-repeat protein PrsT

PEP-CTERM_TPR_PrsT

Family

1,244

false

This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system [ ], analogous to the LPXTG/sortase system common in Gram-positive bacteria. The proteins in this entry occur in a species if, and only if, a transmembrane histidine kinase ( ) and a D...

[]

0

[ "NCBIFAM" ]

[ "TIGR02917" ]

[ "PEP_TPR_lipo" ]

[ 1244 ]

1

[ "GP" ]

[ "GenProp0652" ]

[ "GP:GenProp0652" ]

1

[]

0

[ "PUB00034422" ]

[ "16930487" ]

[ "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Heterosigma akashiwo", "ecological metagenomes" ]

[ 1225, 3, 16 ]

3

[]

0

true

Family

PEP-CTERM system TPR-repeat protein PrsT

PEP-CTERM_TPR_PrsT

3

IPR014267

14,267

Glycosyltransferase GtfA

GtfA

Family

690

false

Glycosyltransferase GtfA is an N-acetylglucosaminyl transferase that is part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon [ , ].

[ "GO:0016757" ]

[ "glycosyltransferase activity" ]

[ "molecular_function" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_01472", "TIGR02918" ]

[ "GtfA", "" ]

[ 672, 690 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.4.1.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313", "PWY-5317...

[ "EC:2.4.1.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139", "METACYC:PWY-5...

200

[ "4pqg", "5e9t", "5e9u" ]

3

[ "PUB00060783", "PUB00064837" ]

[ "15901716", "15489421" ]

[ "Two additional components of the accessory sec system mediating export of the Streptococcus gordonii platelet-binding protein GspB.", "Four proteins encoded in the gspB-secY2A2 operon of Streptococcus gordonii mediate the intracellular glycosylation of the platelet-binding protein GspB." ]

[ 2005, 2004 ]

2

[]

0

null

[ "Bacillati", "human gut metagenome" ]

[ 688, 2 ]

2

[]

0

true

Family

Glycosyltransferase GtfA

GtfA

6

IPR014268

14,268

GtfB

Family

697

false

GtfB is a 445 amino acid protein required for polymorphic O-glycosylation of serine-rich repeat proteins. GtfB, together with GtfA, forms a two-protein enzyme complex that is involved in glycosylation. GtfB stabilises the glycosylation activity of GtfA and forms a heterotetramer complex with GtfA [ , ]. The protein con...

[ "GO:0031647" ]

[ "regulation of protein stability" ]

[ "biological_process" ]

1

[ "HAMAP", "NCBIFAM" ]

[ "MF_01473", "TIGR02919" ]

[ "GtfB", "" ]

[ 688, 695 ]

2

[]

0

[ "5e9t", "5e9u" ]

2

[ "PUB00064842", "PUB00064843", "PUB00064844", "PUB00153994", "PUB00161993" ]

[ "20971868", "18083807", "21862581", "24936067", "28246170" ]

[ "Purification and characterization of an active N-acetylglucosaminyltransferase enzyme complex from Streptococci.", "Interaction between two putative glycosyltransferases is required for glycosylation of a serine-rich streptococcal adhesin.", "A molecular chaperone mediates a two-protein enzyme complex and glyc...

[ 2010, 2008, 2011, 2014, 2017 ]

5

[]

0

null

[ "Bacillati", "human gut metagenome" ]

[ 695, 2 ]

2

[]

0

true

Family

GtfB

9

IPR014269

14,269

Accessory Sec system protein translocase subunit SecY2

SecY2

Family

560

false

Members of this family are restricted to the Firmicutes lineage (low-GC Gram-positive bacteria) and appear to be paralogous to, and much more divergent than, the preprotein translocase SecY. Members include the SecY2 protein of the accessory Sec system in Streptococcus gordonii, involved in export of the highly glycosy...

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_01466", "TIGR02920" ]

[ "SecY2", "acc_sec_Y2" ]

[ 520, 541 ]

2

[]

0

[]

0

[ "PUB00060783" ]

[ "15901716" ]

[ "Two additional components of the accessory sec system mediating export of the Streptococcus gordonii platelet-binding protein GspB." ]

[ 2005 ]

1

[ "IPR002208" ]

[]

1

0

1

[ "Bacteria", "human gut metagenome" ]

[ 559, 1 ]

2

[]

0

true

Family

Accessory Sec system protein translocase subunit SecY2

SecY2

2

IPR014270

14,270

PEP-CTERM integral membrane protein

PEP-CTERM_IMP

Family

86

false

This family includes a group of uncharacterised proteins found mainly in cyanobacteria. These proteins contain a VIT domain . Some members have a PEP-CTERM sequence at the C-terminal ( ), but are unusual among PEP-CTERM proteins in having multiple predicted transmembrane segments. The function is unknown. It is propose...

[]

0

[ "NCBIFAM" ]

[ "TIGR02921" ]

[ "PEP_integral" ]

[ 86 ]

1

[]

0

[]

0

[ "PUB00034422" ]

[ "16930487" ]

[ "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 85, 1 ]

2

[]

0

true

Family

PEP-CTERM integral membrane protein

PEP-CTERM_IMP

3

IPR014271

14,271

Conserved hypothetical protein CHP02922

CHP02922

Family

156

false

Two members of this family are found in Colwellia psychrerythraea (strain 34H / ATCC BAA-681) and one each in various other species of Colwellia and Shewanella. One member from C. psychrerythraea is of special interest because it is preceded by the same cis-regulatory site as a number of genes that have the PEP-CTERM d...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09558", "TIGR02922" ]

[ "DUF2375", "" ]

[ 156, 116 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Alteromonadales" ]

[ 156 ]

1

[]

0

true

Family

Conserved hypothetical protein CHP02922

CHP02922

6

IPR014272

14,272

ATPase, V0 complex, C subunit

ATPase_V0-cplx_csu

Family

819

false

This entry represents the subunit C of the V0 complex. Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ...

[ "GO:0046961", "GO:0033179" ]

[ "proton-transporting ATPase activity, rotational mechanism", "proton-transporting V-type ATPase, V0 domain" ]

[ "molecular_function", "cellular_component" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00314", "TIGR02923" ]

[ "ATP_synth_C_arch", "AhaC" ]

[ 816, 627 ]

2

[ "GP" ]

[ "GenProp0629" ]

[ "GP:GenProp0629" ]

1

[ "1r5z", "1v9m", "3j0j", "5gar", "5gas", "5tsj", "5y5x", "5y5y", "5y5z", "5y60", "6ly9", "6qum", "6r0w", "6r0y", "6r0z", "6r10", "8ywt", "8yxz", "8yy0", "8yy1" ]

20

[ "PUB00007886", "PUB00020603", "PUB00020604", "PUB00020608", "PUB00020609", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789", "PUB00160299" ]

[ "11533110", "15473999", "15078220", "15907459", "15629643", "20450191", "18937357", "1385979", "9741106", "9874757" ]

[ "Structure-function relationships of A-, F- and V-ATPases.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-disciplinary approach.", "A new view of an old pore.", "A structural model of the vac...

[ 2001, 2004, 2004, 2005, 2005, 2010, 2008, 1992, 1998, 1992 ]

10

[ "IPR002843" ]

[]

1

0

1

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 677, 133, 9 ]

3

[]

0

true

Family

ATPase, V0 complex, C subunit

ATPase_V0-cplx_csu

5

IPR014273

14,273

Isocitrate dehydrogenase, bacteria-type

Isocitrate_DH_bac-typ

Family

997

false

This entry represents a group of isocitrate dehydrogenases found mainly in bacteria, including Isocitrate dehydrogenase [NADP] from Rickettsia typhi. Many of the species containing these proteins appear to have a TCA cycle lacking only a determined isocitrate dehydrogenase.

[ "GO:0004450", "GO:0046872", "GO:0006097", "GO:0006099" ]

[ "isocitrate dehydrogenase (NADP+) activity", "metal ion binding", "glyoxylate cycle", "tricarboxylic acid cycle" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "NCBIFAM" ]

[ "TIGR02924" ]

[ "ICDH_alpha" ]

[ 997 ]

1

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.1.1.42", "GenProp0033", "PWY-5913", "PWY-6549", "PWY-6728", "PWY-6969", "PWY-7124", "PWY-7254", "PWY-7268" ]

[ "EC:1.1.1.42", "GP:GenProp0033", "METACYC:PWY-5913", "METACYC:PWY-6549", "METACYC:PWY-6728", "METACYC:PWY-6969", "METACYC:PWY-7124", "METACYC:PWY-7254", "METACYC:PWY-7268" ]

9

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Thermoplasmata", "ecological metagenomes" ]

[ 969, 19, 3, 6 ]

4

[]

0

true

Family

Isocitrate dehydrogenase, bacteria-type

Isocitrate_DH_bac-typ

5

IPR014274

14,274

Peptidyl-prolyl cis-trans isomerase, EpsD-type

PPIase_EpsD

Family

434

false

Proteins in this entry include EpsD from Methylobacillus sp. 12S and belong to the peptidyl-prolyl cis-trans isomerase family. They are located at loci associated with exopolysaccharide biosynthesis and are encoded near a homologue of EpsH ( ).

[]

0

[ "NCBIFAM" ]

[ "TIGR02925" ]

[ "cis_trans_EpsD" ]

[ 434 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "ecological metagenomes" ]

[ 431, 3 ]

2

[]

0

true

Family

Peptidyl-prolyl cis-trans isomerase, EpsD-type

PPIase_EpsD

7

IPR014275

14,275

ATPase, A1A0, subunit H

ATPase_A1A0-cplx_hsu

Family

518

false

Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ...

[]

0

[ "NCBIFAM" ]

[ "TIGR02926" ]

[ "AhaH" ]

[ 518 ]

1

[ "GP" ]

[ "GenProp0629" ]

[ "GP:GenProp0629" ]

1

[]

0

[ "PUB00002959", "PUB00020603", "PUB00020604", "PUB00020617", "PUB00020618", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789" ]

[ "8702544", "15473999", "15078220", "10340845", "15168615", "20450191", "18937357", "1385979", "9741106" ]

[ "Subunit structure and organization of the genes of the A1A0 ATPase from the Archaeon Methanosarcina mazei Go1.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-disciplinary approach.", "Structur...

[ 1996, 2004, 2004, 1999, 2004, 2010, 2008, 1992, 1998 ]

9

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 493, 19, 6 ]

3

[]

0

true

Family

ATPase, A1A0, subunit H

ATPase_A1A0-cplx_hsu

8

IPR014276

14,276

2-oxoglutarate dehydrogenase, E2 component

2-oxoglutarate_DH_E2

Family

4,304

false

This entry represents the mainly actinobacterial clade of the E2 component of the 2-oxoglutarate dehydrogenase complex involved in the TCA cycle. These proteins have multiple domains including the catalytic domain ( ), one or two biotin domains ( ) and an E3-component binding domain ( ).

[]

0

[ "NCBIFAM" ]

[ "TIGR02927" ]

[ "SucB_Actino" ]

[ 4304 ]

1

[ "EC", "REACTOME" ]

[ "2.3.1.12", "R-HSA-1222541" ]

[ "EC:2.3.1.12", "REACTOME:R-HSA-1222541" ]

2

[ "6zzi", "6zzj", "6zzk", "6zzl" ]

4

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4145, 4, 155 ]

3

[]

0

true

Family

2-oxoglutarate dehydrogenase, E2 component

2-oxoglutarate_DH_E2

6

IPR014277

14,277

Orc1/Cdc6-type DNA replication protein, archaea

Orc1/Cdc6_arc

Family

4,176

false

This set of DNA binding proteins are found exclusively in the archaea and show homology to the origin recognition complex subunit 1/cell division control protein 6 (Orc1/Cdc6) family in eukaryotes. Several members may be found in a genome and interact with each other. The Cdc6/Orc1 protein from the archaeon Pyrococcus ...

[]

0

[ "HAMAP", "NCBIFAM" ]

[ "MF_01407", "TIGR02928" ]

[ "ORC1_type_DNA_replic_protein", "" ]

[ 3777, 4167 ]

2

[]

0

[ "1fnn", "1w5s", "1w5t", "2qby", "2v1u" ]

5

[ "PUB00066217" ]

[ "20384788" ]

[ "Cdc6/Orc1 from Pyrococcus furiosus may act as the origin recognition protein and Mcm helicase recruiter." ]

[ 2010 ]

1

[ "IPR050311" ]

[]

1

0

1

[ "Archaea", "Metazoa", "Pseudomonadati", "unclassified sequences" ]

[ 4094, 11, 7, 64 ]

4

[]

0

true

Family

Orc1/Cdc6-type DNA replication protein, archaea

Orc1/Cdc6_arc

2

IPR014278

14,278

Nitrogenase iron-iron, delta subunit

Nase_Fe-Fe_dsu

Family

178

false

Nitrogenase, also called dinitrogenase, is the enzyme which catalyses the conversion of molecular nitrogen to ammonia (biological nitrogen fixation). The most widespread and most efficient nitrogenase contains a molybdenum cofactor. This entry, also known as the AnfG family, represents the delta subunit of the iron-onl...

[ "GO:0005506", "GO:0016163", "GO:0051536", "GO:0009399" ]

[ "iron ion binding", "nitrogenase activity", "iron-sulfur cluster binding", "nitrogen fixation" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "NCBIFAM" ]

[ "TIGR02929" ]

[ "anfG_nitrog" ]

[ 178 ]

1

[ "EC", "GP" ]

[ "1.18.6.1", "GenProp0631" ]

[ "EC:1.18.6.1", "GP:GenProp0631" ]

2

[ "8boq", "8oie" ]

2

[]

0

[ "IPR004349" ]

[]

1

0

1

[ "Bacteria", "Methanobacteriota", "metagenomes" ]

[ 168, 8, 2 ]

3

[]

0

true

Family

Nitrogenase iron-iron, delta subunit

Nase_Fe-Fe_dsu

8

IPR014279

14,279

Nitrogenase vanadium-iron, delta subunit

Nase_V-Fe_dsu

Family

94

false

Nitrogenase, also called dinitrogenase, is the enzyme which catalyses the conversion of molecular nitrogen to ammonia (biological nitrogen fixation). The most widespread and most efficient nitrogenase contains a molybdenum cofactor. This entry, also known as the VnfG family, represents the delta subunit of the vanadium...

[ "GO:0016163", "GO:0046872", "GO:0009399" ]

[ "nitrogenase activity", "metal ion binding", "nitrogen fixation" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR02930" ]

[ "vnfG_nitrog" ]

[ 94 ]

1

[ "EC", "GP" ]

[ "1.18.6.1", "GenProp0632" ]

[ "EC:1.18.6.1", "GP:GenProp0632" ]

2

[ "5n6y", "6fea", "7adr", "7ady", "7aiz" ]

5

[]

0

[ "IPR004349" ]

[]

1

0

1

[ "Bacteria", "Methanosarcina", "mine drainage metagenome" ]

[ 80, 13, 1 ]

3

[]

0

true

Family

Nitrogenase vanadium-iron, delta subunit

Nase_V-Fe_dsu

8

IPR014280

14,280

Nitrogenase iron-iron, beta subunit

Nase_Fe-Fe_bsu

Family

151

false

NNitrogenase, also called dinitrogenase, is the enzyme which catalyses the conversion of molecular nitrogen to ammonia (biological nitrogen fixation). The most widespread and most efficient nitrogenase contains a molybdenum cofactor. This entry, also known as the AnfK family, represents the beta subunit of the iron-onl...

[ "GO:0016163", "GO:0009399" ]

[ "nitrogenase activity", "nitrogen fixation" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR02931" ]

[ "anfK_nitrog" ]

[ 151 ]

1

[ "GP" ]

[ "GenProp0631" ]

[ "GP:GenProp0631" ]

1

[ "8boq", "8oie", "8pbb" ]

3

[ "PUB00060947" ]

[ "2644222" ]

[ "Nucleotide sequence and mutational analysis of the structural genes (anfHDGK) for the second alternative nitrogenase from Azotobacter vinelandii." ]

[ 1989 ]

1

[]

0

null

[ "Bacteria", "Methanobacteriota", "metagenomes" ]

[ 140, 9, 2 ]

3

[]

0

true

Family

Nitrogenase iron-iron, beta subunit

Nase_Fe-Fe_bsu

3

IPR014281

14,281

Nitrogenase vanadium-iron protein beta chain

Nase_VnfK

Family

53

false

Nitrogenase, also called dinitrogenase, is the enzyme which catalyses the conversion of molecular nitrogen to ammonia (biological nitrogen fixation) [ , ]. The most widespread and most efficient nitrogenase contains a molybdenum cofactor. This protein family, VnfK, represents the beta subunit of the vanadium-containing...

[ "GO:0016163", "GO:0051536", "GO:0009399", "GO:0016613" ]

[ "nitrogenase activity", "iron-sulfur cluster binding", "nitrogen fixation", "vanadium-iron nitrogenase complex" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR02932" ]

[ "vnfK_nitrog" ]

[ 53 ]

1

[ "EC", "GP" ]

[ "1.18.6.1", "GenProp0632" ]

[ "EC:1.18.6.1", "GP:GenProp0632" ]

2

[ "5n6y", "6fea", "7adr", "7ady", "7aiz" ]

5

[ "PUB00075351", "PUB00075352" ]

[ "2743980", "2388847" ]

[ "Structural genes for the vanadium nitrogenase from Azotobacter chroococcum.", "Completed sequence of the region encoding the structural genes for the vanadium nitrogenase of Azotobacter chroococcum." ]

[ 1989, 1990 ]

2

[]

0

null

[ "Bacteria", "Methanosarcina", "mine drainage metagenome" ]

[ 40, 12, 1 ]

3

[]

0

true

Family

Nitrogenase vanadium-iron protein beta chain

Nase_VnfK

4

IPR014282

14,282

Nitrogen fixation protein NifM

Nitrogen_fix_NifM

Family

317

false

Members of this entry are found in a subset of nitrogen-fixing bacteria and are annotated as nitrogen fixation protein NifM. NifM is homologous to peptidyl-prolyl cis-trans isomerases and appears to be an accessory protein for NifH, the Fe protein, also called component II or dinitrogenase reductase, of nitrogenase [ ]...

[]

0

[ "NCBIFAM" ]

[ "TIGR02933" ]

[ "nifM_nitrog" ]

[ 317 ]

1

[ "EC", "GP" ]

[ "5.2.1.8", "GenProp0029" ]

[ "EC:5.2.1.8", "GP:GenProp0029" ]

2

[]

0

[ "PUB00034590" ]

[ "10772917" ]

[ "NifH and NifM proteins interact as demonstrated by the yeast two-hybrid system." ]

[ 2000 ]

1

[]

0

null

[ "Pseudomonadota", "ecological metagenomes" ]

[ 310, 7 ]

2

[]

0

true

Family

Nitrogen fixation protein NifM

Nitrogen_fix_NifM

8

IPR014283

14,283

Ferredoxin III 4[4Fe-4S], nif-specific

FdIII_4_nif

Family

1,134

false

This entry consists of ferredoxins which are encoded in the nitrogen fixation regions of many nitrogen-fixing bacteria. The charcterised protein from Rhodobacter capsulatus (Rhodopseudomonas capsulata) is homodimeric and contains two [4Fe-4S] clusters bound per monomer. Although nif-specific, these prtoeins are not uni...

[]

0

[ "NCBIFAM" ]

[ "TIGR02936" ]

[ "fdxN_nitrog" ]

[ 1134 ]

1

[ "GP" ]

[ "GenProp0029" ]

[ "GP:GenProp0029" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1120, 14 ]

2

[]

0

true

Family

Ferredoxin III 4[4Fe-4S], nif-specific

FdIII_4_nif

7

IPR014284

14,284

RNA polymerase sigma-70-like domain

RNA_pol_sigma-70_dom

Domain

419,647

false

This entry is found in all varieties of the sigma-70 type sigma factors, including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family ( ) are included within this entry. The bacterial core RNA polymerase complex, which...

[ "GO:0003700", "GO:0006352", "GO:0006355" ]

[ "DNA-binding transcription factor activity", "DNA-templated transcription initiation", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "NCBIFAM" ]

[ "TIGR02937" ]

[ "sigma70-ECF" ]

[ 419647 ]

1

[]

0

[ "1h3l", "1iw7", "1ku2", "1ku3", "1ku7", "1l0o", "1l9u", "1l9z", "1or7", "1rio", "1rp3", "1sc5", "1sig", "1smy", "1tlh", "1tty", "1zyr", "2a68", "2a69", "2a6e", "2a6h", "2be5", "2cw0", "2h27", "2mao", "2map", "2o7g", "2q1z", "2z2s", "3dxj", "3eql", "3hug"...

408

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Plastid sigma factors: Their individual functions and regulation in transcription."...

[ 1988, 1992, 1986, 2015 ]

4

[]

[ "IPR000943" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 17, 409718, 5155, 376, 4381 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 23, 6, 20, 44 ]

4

true

Domain

RNA polymerase sigma-70-like domain

RNA_pol_sigma-70_dom

2

IPR014285

14,285

Nitrogen fixation negative regulator NifL

N_fixation_neg-reg_NifL

Family

353

false

NifL from Azotobacter vinelandii senses both the redox and fixed nitrogen status to regulate nitrogen fixation. NifL acts by modulating the activity of the nitrogen fixation positive regulator protein NifA; NifL inhibits NifA in response to oxygen and low level of fixed nitrogen. NifA and NifL are encoded by adjacent g...

[ "GO:0007165", "GO:0009399" ]

[ "signal transduction", "nitrogen fixation" ]

[ "biological_process", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR02938" ]

[ "nifL_nitrog" ]

[ 353 ]

1

[]

0

[ "9qq6" ]

1

[ "PUB00042901" ]

[ "17355964" ]

[ "Role of the H domain of the histidine kinase-like protein NifL in signal transmission." ]

[ 2007 ]

1

[]

0

null

[ "Plasmodium yoelii yoelii", "Pseudomonadota", "ecological metagenomes" ]

[ 1, 346, 6 ]

3

[]

0

true

Family

Nitrogen fixation negative regulator NifL

N_fixation_neg-reg_NifL

8

IPR014286

14,286

RNA polymerase sigma-70 RpoE type

RNA_pol_sigma70_RpoE

Family

5,015

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[ "GO:0003677", "GO:0003700", "GO:0016987", "GO:0006352", "GO:0006355" ]

[ "DNA binding", "DNA-binding transcription factor activity", "sigma factor activity", "DNA-templated transcription initiation", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "NCBIFAM" ]

[ "TIGR02939" ]

[ "RpoE_Sigma70" ]

[ 5015 ]

1

[ "GP" ]

[ "GenProp1184" ]

[ "GP:GenProp1184" ]

1

[ "1or7", "6in7", "6jbq", "8z6g" ]

4

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Plastid sigma factors: Their individual functions and regulation in transcription."...

[ 1988, 1992, 1986, 2015 ]

4

[ "IPR039425" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4948, 7, 60 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

RNA polymerase sigma-70 RpoE type

RNA_pol_sigma70_RpoE

4

IPR014287

14,287

Nitrogenase iron-iron, accessory protein AnfO

Nase_Fe-Fe_AnfO

Family

335

false

Proteins in this entry include Anf1 from Rhodobacter capsulatus (Rhodopseudomonas capsulata) and AnfO from Azotobacter vinelandii. They are found exclusively in species which contain the iron-only nitrogenase, and are encoded immediately downstream of the structural genes for the nitrogenase enzyme in these species.

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09582", "TIGR02940" ]

[ "AnfO_nitrog", "anfO_nitrog" ]

[ 335, 114 ]

2

[ "GP" ]

[ "GenProp0631" ]

[ "GP:GenProp0631" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanomicrobia", "metagenomes" ]

[ 291, 39, 5 ]

3

[]

0

true

Family

Nitrogenase iron-iron, accessory protein AnfO

Nase_Fe-Fe_AnfO

3

IPR014288

14,288

RNA polymerase sigma-B factor

RNA_pol_sigma-B

Family

1,294

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[ "GO:0016987" ]

[ "sigma factor activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR02941" ]

[ "Sigma_B" ]

[ 1294 ]

1

[]

0

[ "8x6g" ]

1

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00034423", "PUB00034424", "PUB00034425", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "16644280", "15528669", "14702299", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "The sigmaB regulon in Staphylococcus aureus and its regulation.", "sigmaB-depende...

[ 1988, 1992, 1986, 2006, 2004, 2004, 2015 ]

7

[ "IPR014322" ]

[]

1

0

1

[ "Bacilli" ]

[ 1294 ]

1

[]

0

true

Family

RNA polymerase sigma-B factor

RNA_pol_sigma-B

6

IPR014289

14,289

RNA polymerase sigma-24-related

RNA_pol_sigma-24-rel

Family

1,446

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[]

0

[ "NCBIFAM" ]

[ "TIGR02943" ]

[ "Sig70_famx1" ]

[ 1446 ]

1

[]

0

[]

0

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Plastid sigma factors: Their individual functions and regulation in transcription."...

[ 1988, 1992, 1986, 2015 ]

4

[]

0

null

[ "Bacteria", "Candidatus Sysuiplasma superficiale", "ecological metagenomes" ]

[ 1423, 1, 22 ]

3

[]

0

true

Family

RNA polymerase sigma-24-related

RNA_pol_sigma-24-rel

6

IPR014290

14,290

SUF system FeS cluster assembly regulator

SUF_FeS_clus_asmbl_reg

Family

1,739

false

Iron-sulphur (FeS) clusters are important cofactors for numerous proteins involved in electron transfer, in redox and non-redox catalysis, in gene regulation, and as sensors of oxygen and iron. These functions depend on the various FeS cluster prosthetic groups, the most common being [2Fe-2S] and [4Fe-4S] [ ]. FeS clus...

[]

0

[ "NCBIFAM" ]

[ "TIGR02944" ]

[ "suf_reg_Xantho" ]

[ 1739 ]

1

[ "GP" ]

[ "GenProp0137" ]

[ "GP:GenProp0137" ]

1

[]

0

[ "PUB00003442", "PUB00028014", "PUB00035635", "PUB00035636", "PUB00035637", "PUB00035638", "PUB00035639", "PUB00035640" ]

[ "8875867", "11498000", "16221578", "16211402", "16843540", "15937904", "17350000", "15278785" ]

[ "A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution.", "Incorporation of iron-sulphur clusters in membrane-bound proteins.", "How Escherichia coli and Saccharomyces cerevisiae build Fe/S proteins.", "Mechanisms of iron-sulfur cluster assembly: the SUF machinery.", ...

[ 1996, 2001, 2005, 2005, 2006, 2005, 2007, 2004 ]

8

[ "IPR000944" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "unclassified Candidatus Thermoprofundales", "unclassified sequences" ]

[ 1699, 4, 5, 31 ]

4

[]

0

true

Family

SUF system FeS cluster assembly regulator

SUF_FeS_clus_asmbl_reg

1

IPR014291

14,291

SUF system FeS cluster assembly associated

SUF_FeS_clus_asmbl-assoc

Family

3,717

false

Iron-sulphur (FeS) clusters are important cofactors for numerous proteins involved in electron transfer, in redox and non-redox catalysis, in gene regulation, and as sensors of oxygen and iron. These functions depend on the various FeS cluster prosthetic groups, the most common being [2Fe-2S] and [4Fe-4S] [ ]. FeS clus...

[]

0

[ "NCBIFAM" ]

[ "TIGR02945" ]

[ "SUF_assoc" ]

[ 3717 ]

1

[ "GP" ]

[ "GenProp0137" ]

[ "GP:GenProp0137" ]

1

[]

0

[ "PUB00003442", "PUB00028014", "PUB00035635", "PUB00035636", "PUB00035637", "PUB00035638", "PUB00035639", "PUB00035640" ]

[ "8875867", "11498000", "16221578", "16211402", "16843540", "15937904", "17350000", "15278785" ]

[ "A modular domain of NifU, a nitrogen fixation cluster protein, is highly conserved in evolution.", "Incorporation of iron-sulphur clusters in membrane-bound proteins.", "How Escherichia coli and Saccharomyces cerevisiae build Fe/S proteins.", "Mechanisms of iron-sulfur cluster assembly: the SUF machinery.", ...

[ 1996, 2001, 2005, 2005, 2006, 2005, 2007, 2004 ]

8

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes", "unclassified Candidatus Thermoprofundales" ]

[ 3666, 7, 41, 3 ]

4

[]

0

true

Family

SUF system FeS cluster assembly associated

SUF_FeS_clus_asmbl-assoc

1

IPR014292

14,292

Acyltransferase, WS/DGAT/MGAT

Acyl_transf_WS/DGAT

Family

9,381

false

This bacteria-specific protein family includes a characterised, homodimeric, broad specificity acyltransferase from Acinetobacter sp. (strain ADP1). It has been shown to function as a wax ester synthase, acyl coenzyme A:diacylglycerol acyltransferase, and as a acyl-CoA:monoacylglycerol acyltransferase [ , ]. This enzym...

[ "GO:0016746", "GO:0045017" ]

[ "acyltransferase activity", "glycerolipid biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR02946" ]

[ "acyl_WS_DGAT" ]

[ 9381 ]

1

[ "EC" ]

[ "2.3.1.20" ]

[ "EC:2.3.1.20" ]

1

[ "6chj", "7nxg" ]

2

[ "PUB00034594", "PUB00099694", "PUB00099696", "PUB00099697", "PUB00099698", "PUB00099699", "PUB00099700", "PUB00099701" ]

[ "15687201", "34443455", "18399520", "15574908", "12502715", "16938377", "16461689", "15691932" ]

[ "The wax ester synthase/acyl coenzyme A:diacylglycerol acyltransferase from Acinetobacter sp. strain ADP1: characterization of a novel type of acyltransferase.", "<i>Rhodococcus</i> as Biofactories for Microbial Oil Production.", "Bacterial acyltransferases as an alternative for lipase-catalyzed acylation for t...

[ 2005, 2021, 2008, 2004, 2003, 2007, 2006, 2005 ]

8

[ "IPR045034" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Halobacteria", "metagenomes" ]

[ 9302, 7, 5, 67 ]

4

[]

0

true

Family

Acyltransferase, WS/DGAT/MGAT

Acyl_transf_WS/DGAT

6

IPR014293

14,293

RNA polymerase sigma-70, actinobacteria

RNA_pol_sigma70_actinobac

Family

4,703

false

This group of sigma factors are members of the sigma-70 family ( ). They and appear by homology, tree building, bidirectional best hits and (with one exception, a paralog in Thermobifida fusca strain YX) their one-to-a-genome distribution, to represent a conserved family. This family is restricted to the Actinobacteria...

[ "GO:0003677", "GO:0003700", "GO:0016987", "GO:0006352", "GO:0006355" ]

[ "DNA binding", "DNA-binding transcription factor activity", "sigma factor activity", "DNA-templated transcription initiation", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "NCBIFAM" ]

[ "TIGR02947" ]

[ "SigH_actino" ]

[ 4703 ]

1

[]

0

[ "5zx2", "5zx3", "6jcx", "6kon", "6koo", "6kop", "6koq" ]

7

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Plastid sigma factors: Their individual functions and regulation in transcription."...

[ 1988, 1992, 1986, 2015 ]

4

[ "IPR039425" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4575, 3, 125 ]

3

[]

0

true

Family

RNA polymerase sigma-70, actinobacteria

RNA_pol_sigma70_actinobac

5

IPR014296

14,296

RNA polymerase sigma-M, bacillaceae

RNA_pol_sigma-M_bacilli

Family

636

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[ "GO:0003677", "GO:0003700", "GO:0016987", "GO:0006352", "GO:0006355" ]

[ "DNA binding", "DNA-binding transcription factor activity", "sigma factor activity", "DNA-templated transcription initiation", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "biological_process" ]

5

[ "NCBIFAM" ]

[ "TIGR02950" ]

[ "SigM_subfam" ]

[ 636 ]

1

[]

0

[]

0

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00034426", "PUB00034427", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "12775685", "10216858", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "SigM, an extracytoplasmic function sigma factor of Bacillus subtilis, is activated ...

[ 1988, 1992, 1986, 2003, 1999, 2015 ]

6

[ "IPR039425" ]

[]

1

0

1

[ "Bacillota" ]

[ 636 ]

1

[]

0

true

Family

RNA polymerase sigma-M, bacillaceae

RNA_pol_sigma-M_bacilli

1

IPR014297

14,297

Dimethylsulphoxide reductase, chain B

DMSO_DmsB

Family

3,633

false

This family consists of the iron-sulphur subunit, or chain B, of the anaerobic dimethyl sulphoxide reductase enzyme. Chains A and B are catalytic, while chain C is a membrane anchor.

[]

0

[ "NCBIFAM" ]

[ "TIGR02951" ]

[ "DMSO_dmsB" ]

[ 3633 ]

1

[ "GP", "GP" ]

[ "GenProp0637", "GenProp1148" ]

[ "GP:GenProp0637", "GP:GenProp1148" ]

2

[]

0

[]

0

[]

0

null

[ "Bacteria", "Escherichia phage RCS47", "Eukaryota", "metagenomes" ]

[ 3619, 1, 4, 9 ]

4

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Dimethylsulphoxide reductase, chain B

DMSO_DmsB

6

IPR014299

14,299

Pentapeptide MXKDX repeat protein

Penta_MxKDx

Family

1,041

false

Members of this protein family are small bacterial proteins, each with an N-terminal signal sequence followed by up to 11 imperfect repeats of a pentapeptide. The pentapeptide repeat is usually of the form Met-Xaa-Lys-Asp-Xaa. Family member methionine-rich peptide X, from Dechlorosoma suillum, has been shown to serve a...

[]

0

[ "NCBIFAM" ]

[ "TIGR02953" ]

[ "penta_MxKDx" ]

[ 1041 ]

1

[]

0

[]

0

[ "PUB00086028" ]

[ "25968643" ]

[ "Novel mechanism for scavenging of hypochlorite involving a periplasmic methionine-rich Peptide and methionine sulfoxide reductase." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 1032, 9 ]

2

[]

0

true

Family

Pentapeptide MXKDX repeat protein

Penta_MxKDx

5

IPR014300

14,300

RNA polymerase sigma-V type

RNA_pol_sigma-V

Family

458

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[]

0

[ "NCBIFAM" ]

[ "TIGR02954" ]

[ "Sig70_famx3" ]

[ 458 ]

1

[]

0

[]

0

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Plastid sigma factors: Their individual functions and regulation in transcription."...

[ 1988, 1992, 1986, 2015 ]

4

[ "IPR039425" ]

[]

1

0

1

[ "Bacteria" ]

[ 458 ]

1

[]

0

true

Family

RNA polymerase sigma-V type

RNA_pol_sigma-V

8

IPR014301

14,301

TMAO reductase system, periplasmic protein TorT

TMAO_TorT

Family

1,184

false

Periplasmic protein TorT, together with the TorS/TorR histidine kinase/response regulator system, regulates expression of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase system [ ]. TorT appears to bind TMAO or related compounds, and is predicted to be involved in signal transduction and/or...

[]

0

[ "NCBIFAM" ]

[ "TIGR02955" ]

[ "TMAO_TorT" ]

[ 1184 ]

1

[]

0

[ "3o1h", "3o1i", "3o1j" ]

3

[ "PUB00034595", "PUB00080991" ]

[ "8576063", "17040909" ]

[ "The periplasmic TorT protein is required for trimethylamine N-oxide reductase gene induction in Escherichia coli.", "TorT, a member of a new periplasmic binding protein family, triggers induction of the Tor respiratory system upon trimethylamine N-oxide electron-acceptor binding in Escherichia coli." ]

[ 1996, 2006 ]

2

[]

0

null

[ "Bacteria" ]

[ 1184 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

TMAO reductase system, periplasmic protein TorT

TMAO_TorT

3

IPR014302

14,302

Signal transduction histidine kinase, TMAO sensor TorS

Sig_transdc_His_kinase_TorS

Family

1,597

false

This entry represents TorS proteins, which are part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding prot...

[ "GO:0000155", "GO:0004673", "GO:0000160", "GO:0016020" ]

[ "phosphorelay sensor kinase activity", "protein histidine kinase activity", "phosphorelay signal transduction system", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF036437", "TIGR02956" ]

[ "HK_TorS", "TMAO_torS" ]

[ 1490, 1553 ]

2

[]

0

[]

0

[ "PUB00000966", "PUB00007866", "PUB00010651", "PUB00011096", "PUB00013246", "PUB00013247", "PUB00013562", "PUB00013563", "PUB00020801", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807" ]

[ "9989504", "11406410", "12372152", "10966457", "8868347", "10426948", "8029829", "1482126", "11145881", "16176121", "18076326", "11934609", "11489844" ]

[ "Structure of CheA, a signal-transducing histidine kinase.", "Histidine kinases and response regulator proteins in two-component signaling systems.", "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Protein aspartate phosphatases control...

[ 1999, 2001, 2002, 2000, 1996, 1999, 1994, 1992, 2000, 2005, 2007, 2002, 2001 ]

13

[]

0

null

[ "Bacteria" ]

[ 1597 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Signal transduction histidine kinase, TMAO sensor TorS

Sig_transdc_His_kinase_TorS

4

IPR014303

14,303

RNA polymerase sigma-70, ECF type

RNA_pol_sigma-70_ECF

Family

7,680

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[]

0

[ "NCBIFAM" ]

[ "TIGR02957" ]

[ "SigX4" ]

[ 7680 ]

1

[]

0

[]

0

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Plastid sigma factors: Their individual functions and regulation in transcription."...

[ 1988, 1992, 1986, 2015 ]

4

[]

0

null

[ "Bacteria", "Chaetothyriales", "metagenomes" ]

[ 7669, 3, 8 ]

3

[]

0

true

Family

RNA polymerase sigma-70, ECF type

RNA_pol_sigma-70_ECF

2

IPR014304

14,304

RNA polymerase sigma-Z type

RNA_pol_sigma-Z

Family

602

false

This entry is a group of RNA polymerase sigma factors where one of the members is designated as SigZ in Bacillus subtilis [ ]. This group has a very sporadic distribution, B. subtilis, for instance, being the only sequenced strain of Bacilli with a member Dechloromonas aromatica (strain RCB), that appears to have two o...

[]

0

[ "NCBIFAM" ]

[ "TIGR02959" ]

[ "SigZ" ]

[ 602 ]

1

[]

0

[]

0

[ "PUB00034428" ]

[ "9308178" ]

[ "Sequence of the Bacillus subtilis genome region in the vicinity of the lev operon reveals two new extracytoplasmic function RNA polymerase sigma factors SigV and SigZ." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 595, 7 ]

2

[]

0

true

Family

RNA polymerase sigma-Z type

RNA_pol_sigma-Z

2

IPR014305

14,305

RNA polymerase sigma-G type, actinobacteria

RNA_pol_sigma-G_actinobac

Family

6,452

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[]

0

[ "NCBIFAM" ]

[ "TIGR02960" ]

[ "SigX5" ]

[ 6452 ]

1

[]

0

[ "7qh5" ]

1

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Plastid sigma factors: Their individual functions and regulation in transcription."...

[ 1988, 1992, 1986, 2015 ]

4

[ "IPR039425" ]

[]

1

0

1

[ "Bacteria", "Rhynchospora breviuscula", "metagenomes" ]

[ 6444, 1, 7 ]

3

[]

0

true

Family

RNA polymerase sigma-G type, actinobacteria

RNA_pol_sigma-G_actinobac

6

IPR014307

14,307

Xanthine dehydrogenase, small subunit

Xanthine_DH_ssu

Domain

7,431

false

Members of this protein are the small subunit (or, in eukaryotes, the N-terminal domain) of xanthine dehydrogenase, an enzyme of purine catabolism via urate [ ]. The small subunit contains both an FAD and a 2Fe-2S cofactor. Aldehyde oxidase (retinal oxidase) appears to have arisen as a neofunctionalisation among xanthi...

[ "GO:0004854", "GO:0050660" ]

[ "xanthine dehydrogenase activity", "flavin adenine dinucleotide binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "NCBIFAM" ]

[ "TIGR02963" ]

[ "xanthine_xdhA" ]

[ 7431 ]

1

[ "EC", "GP", "GP", "GP", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME"...

[ "1.17.1.4", "GenProp0640", "GenProp1236", "GenProp1255", "GenProp1469", "GenProp1753", "PWY-5497", "PWY-5695", "PWY-6538", "PWY-6596", "PWY-6606", "PWY-6607", "PWY-6608", "PWY-6999", "R-DME-74259", "R-DME-964975", "R-DME-9748787", "R-GGA-421178", "R-HSA-74259", "R-HSA-8851680",...

[ "EC:1.17.1.4", "GP:GenProp0640", "GP:GenProp1236", "GP:GenProp1255", "GP:GenProp1469", "GP:GenProp1753", "METACYC:PWY-5497", "METACYC:PWY-5695", "METACYC:PWY-6538", "METACYC:PWY-6596", "METACYC:PWY-6606", "METACYC:PWY-6607", "METACYC:PWY-6608", "METACYC:PWY-6999", "REACTOME:R-DME-74259",...

27

[ "1fo4", "1jro", "1jrp", "1n5x", "1v97", "1vdv", "1wyg", "2ckj", "2e1q", "2e3t", "2w3r", "2w3s", "2w54", "2w55", "3am9", "3amz", "3an1", "3ax7", "3ax9", "3bdj", "3una", "3unc", "3uni", "4yrw", "4ysw", "4yty", "4ytz", "6a7x", "6abu", "6ac1", "6ac4", "6ad4"...

35

[ "PUB00100884" ]

[ "27537049" ]

[ "Xanthine dehydrogenase: An old enzyme with new knowledge and prospects." ]

[ 2016 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 4765, 2634, 32 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 2, 1, 2, 3, 1, 3 ]

7

true

Domain

Xanthine dehydrogenase, small subunit

Xanthine_DH_ssu

2

IPR014308

14,308

Xanthine dehydrogenase accessory protein XdhC

Xanthine_DH_XdhC

Family

5,531

false

Members of this family are the accessory protein XdhC, found in bacteria, that is responsible for insertion of the molybdenum cofactor into the xanthine dehydrogenase large chain, XdhB. This protein is not part of the mature xanthine dehydrogenase. Xanthine dehydrogenase is an enzyme for purine catabolism, from other p...

[]

0

[ "NCBIFAM" ]

[ "TIGR02964" ]

[ "xanthine_xdhC" ]

[ 5531 ]

1

[ "GP" ]

[ "GenProp0640" ]

[ "GP:GenProp0640" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5488, 4, 39 ]

3

[]

0

true

Family

Xanthine dehydrogenase accessory protein XdhC

Xanthine_DH_XdhC

8

IPR014309

14,309

Xanthine dehydrogenase, molybdopterin binding subunit

Xanthine_DH_Mopterin-bd_su

Domain

5,963

false

Members of this entry are the molybdopterin-containing large subunit of xanthine dehydrogenase (or, in, eukaryotes, the molybdopterin-binding domain) and those enzymes that reduces the purine pool by catabolizing xanthine to urate. This entry contains primarily bacterial sequences; it does not manage to include all euk...

[ "GO:0030151" ]

[ "molybdenum ion binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR02965" ]

[ "xanthine_xdhB" ]

[ 5963 ]

1

[ "GP", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp0640", "GenProp1469", "GenProp1753", "R-GGA-421178", "R-MMU-74259", "R-MMU-8851680", "R-MMU-9748787" ]

[ "GP:GenProp0640", "GP:GenProp1469", "GP:GenProp1753", "REACTOME:R-GGA-421178", "REACTOME:R-MMU-74259", "REACTOME:R-MMU-8851680", "REACTOME:R-MMU-9748787" ]

7

[ "1jro", "1jrp", "2w3r", "2w3s", "2w54", "2w55" ]

6

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 5542, 388, 33 ]

3

[ "Danio rerio", "Mus musculus" ]

[ 1, 3 ]

2

true

Domain

Xanthine dehydrogenase, molybdopterin binding subunit

Xanthine_DH_Mopterin-bd_su

2

IPR014310

14,310

Signal transduction histidine kinase, phosphate regulon sensor PhoR

Sig_transdc_His_kinase_PhoR

Family

6,510

false

Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ ]. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk [ ]. These pathways have been adapt...

[ "GO:0000155", "GO:0004673", "GO:0000160", "GO:0016020" ]

[ "phosphorelay sensor kinase activity", "protein histidine kinase activity", "phosphorelay signal transduction system", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "NCBIFAM" ]

[ "TIGR02966" ]

[ "phoR_proteo" ]

[ 6510 ]

1

[ "EC", "GP" ]

[ "2.7.13.3", "GenProp0190" ]

[ "EC:2.7.13.3", "GP:GenProp0190" ]

2

[]

0

[ "PUB00000966", "PUB00007866", "PUB00010651", "PUB00011096", "PUB00013246", "PUB00013247", "PUB00013562", "PUB00013563", "PUB00020801", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807" ]

[ "9989504", "11406410", "12372152", "10966457", "8868347", "10426948", "8029829", "1482126", "11145881", "16176121", "18076326", "11934609", "11489844" ]

[ "Structure of CheA, a signal-transducing histidine kinase.", "Histidine kinases and response regulator proteins in two-component signaling systems.", "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Protein aspartate phosphatases control...

[ 1999, 2001, 2002, 2000, 1996, 1999, 1994, 1992, 2000, 2005, 2007, 2002, 2001 ]

13

[ "IPR050351" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6456, 8, 46 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Signal transduction histidine kinase, phosphate regulon sensor PhoR

Sig_transdc_His_kinase_PhoR

9

IPR014311

14,311

Guanine deaminase

Guanine_deaminase

Family

9,644

false

This entry describes guanine deaminase, which hydrolyses guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. Xanthine can then be converted to urate by xanthine dehydrogenase. This reaction also removes the guanine base from the pool and therefore can play a role in the regulation o...

[ "GO:0008270", "GO:0008892", "GO:0006147" ]

[ "zinc ion binding", "guanine deaminase activity", "guanine catabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "NCBIFAM", "CDD" ]

[ "TIGR02967", "cd01303" ]

[ "guan_deamin", "GDEase" ]

[ 9611, 4592 ]

2

[ "EC", "GP", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.5.4.3", "GenProp0698", "GenProp1469", "PWY-5497", "PWY-6606", "PWY-6608", "PWY-7442", "R-DDI-74259", "R-DME-74259", "R-HSA-74259", "R-MMU-74259", "R-RNO-74259", "R-SCE-74259", "R-SPO-74259" ]

[ "EC:3.5.4.3", "GP:GenProp0698", "GP:GenProp1469", "METACYC:PWY-5497", "METACYC:PWY-6606", "METACYC:PWY-6608", "METACYC:PWY-7442", "REACTOME:R-DDI-74259", "REACTOME:R-DME-74259", "REACTOME:R-HSA-74259", "REACTOME:R-MMU-74259", "REACTOME:R-RNO-74259", "REACTOME:R-SCE-74259", "REACTOME:R-SPO-...

14

[ "2i9u", "2ood", "2uz9", "3e0l", "4aql", "6oh9", "6oha", "6ohb", "6ohc" ]

9

[ "PUB00034599", "PUB00081356", "PUB00081357" ]

[ "10913105", "10075721", "11101664" ]

[ "Identification, expression, and characterization of Escherichia coli guanine deaminase.", "Cloning and characterization of human guanine deaminase. Purification and partial amino acid sequence of the mouse protein.", "Bacillus subtilis guanine deaminase is encoded by the yknA gene and is induced during growth ...

[ 2000, 1999, 2000 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 6694, 2917, 2, 31 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe...

[ 1, 1, 1, 1, 7, 2, 4, 1, 1 ]

9

true

Family

Guanine deaminase

Guanine_deaminase

6

IPR014312

14,312

Succinate dehydrogenase, hydrophobic membrane anchor

Succ_DH_anchor

Family

8,723

false

In Escherichia coli and many other bacteria, two small, hydrophobic, mutually homologous subunits of succinate dehydrogenase (a TCA cycle enzyme) are SdhC and SdhD [ ]. This entry is the SdhD, the hydrophobic membrane anchor protein. SdhC is apocytochrome b558, which also plays a role in anchoring the complex.

[ "GO:0020037", "GO:0006099", "GO:0016020" ]

[ "heme binding", "tricarboxylic acid cycle", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF", "PANTHER", "NCBIFAM" ]

[ "PIRSF000169", "PTHR38689", "TIGR02968" ]

[ "SDH_D", "", "succ_dehyd_anc" ]

[ 4898, 5699, 8629 ]

3

[ "GP", "GP", "GP", "GP" ]

[ "GenProp0033", "GenProp1112", "GenProp1493", "GenProp1515" ]

[ "GP:GenProp0033", "GP:GenProp1112", "GP:GenProp1493", "GP:GenProp1515" ]

4

[ "1nek", "1nen", "2acz", "2wdq", "2wdr", "2wdv", "2wp9", "2ws3", "2wu2", "2wu5", "6wu6", "7jz2" ]

12

[ "PUB00034600" ]

[ "8637872" ]

[ "Genes encoding the same three subunits of respiratory complex II are present in the mitochondrial DNA of two phylogenetically distant eukaryotes." ]

[ 1996 ]

1

[ "IPR000701" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2, 8605, 13, 103 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Succinate dehydrogenase, hydrophobic membrane anchor

Succ_DH_anchor

5

IPR014313

14,313

Aldehyde oxidase

Aldehyde_oxidase

Family

1,098

false

Aldehyde oxidase catalyses the reaction: aldehyde + H2O + O2 = a carboxylic acid + H2O2 It contains molybdenum, [2Fe-2S] centres and FAD. It also oxidizes quinoline and pyridine derivatives. It is probably identical to retinal oxidase ( ) [ ]. Aldehyde oxidase oxidises various aliphatic and aromatic aldehydes using oxy...

[ "GO:0016491", "GO:0046872", "GO:0051287" ]

[ "oxidoreductase activity", "metal ion binding", "NAD binding" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "NCBIFAM" ]

[ "TIGR02969" ]

[ "mam_aldehyde_ox" ]

[ 1098 ]

1

[ "EC", "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.17.3.-", "1.2.3.1", "PWY-8084", "R-HSA-964975", "R-MMU-964975", "R-RNO-964975" ]

[ "EC:1.17.3.-", "EC:1.2.3.1", "METACYC:PWY-8084", "REACTOME:R-HSA-964975", "REACTOME:R-MMU-964975", "REACTOME:R-RNO-964975" ]

6

[ "3zyv", "4uhw", "4uhx", "5epg", "6q6q", "7opn", "7orc", "8emt" ]

8

[ "PUB00043465", "PUB00043466" ]

[ "10190983", "14659539" ]

[ "Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli.", "Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690." ]

[ 1999, 2003 ]

2

[ "IPR016208" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 1098 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 11, 13 ]

3

true

Family

Aldehyde oxidase

Aldehyde_oxidase

8

IPR014314

14,314

Succinate dehydrogenase, cytochrome b556 subunit

Succ_DH_cytb556

Family

17,964

false

In Escherichia coli and many other bacteria, two small, hydrophobic, mutually homologous subunits of succinate dehydrogenase (a TCA cycle enzyme) are SdhC and SdhD. This entry represents SdhC, the cytochrome b subunit, called b556 in bacteria and b560 in mitochondria. SdhD (see ) is called the hydrophobic membrane anch...

[ "GO:0009055", "GO:0006099" ]

[ "electron transfer activity", "tricarboxylic acid cycle" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF", "PANTHER", "NCBIFAM", "CDD" ]

[ "PIRSF000178", "PTHR10978", "TIGR02970", "cd03499" ]

[ "SDH_cyt_b560", "", "succ_dehyd_cytB", "SQR_TypeC_SdhC" ]

[ 10876, 13034, 16455, 13798 ]

4

[ "GP", "GP", "GP", "GP", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "GenProp0033", "GenProp1112", "GenProp1493", "GenProp1515", "GenProp1693", "R-BTA-71403", "R-BTA-9854311", "R-DDI-71403", "R-HSA-611105", "R-HSA-71403", "R-HSA-9854311", "R-MMU-71403", "R-MMU-9854311", "R-SCE-71403", "R-SPO-71403", "R-SSC-71403", "R-SSC-9854311" ]

[ "GP:GenProp0033", "GP:GenProp1112", "GP:GenProp1493", "GP:GenProp1515", "GP:GenProp1693", "REACTOME:R-BTA-71403", "REACTOME:R-BTA-9854311", "REACTOME:R-DDI-71403", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-71403", "REACTOME:R-HSA-9854311", "REACTOME:R-MMU-71403", "REACTOME:R-MMU-9854311", "...

17

[ "1nek", "1nen", "1yq3", "1yq4", "1zoy", "1zp0", "2acz", "2fbw", "2h88", "2h89", "2wdq", "2wdr", "2wdv", "2wp9", "2wqy", "2ws3", "2wu2", "2wu5", "3abv", "3ae1", "3ae2", "3ae3", "3ae4", "3ae5", "3ae6", "3ae7", "3ae8", "3ae9", "3aea", "3aeb", "3aec", "3aed"...

67

[ "PUB00152800" ]

[ "37490987" ]

[ "Assembly of mitochondrial succinate dehydrogenase in human health and disease." ]

[ 2023 ]

1

[ "IPR000701" ]

[ "IPR039023" ]

1

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 341, 12185, 5287, 151 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 10, 2, 1, 3, 1, 11, 4, 1, 2, 7, 2, 1, 4 ]

13

true

Family

Succinate dehydrogenase, cytochrome b556 subunit

Succ_DH_cytb556

3

IPR014315

14,315

ABC transporter, membrane fusion protein, DevB type

ABC_heterocyst_DevB

Family

1,358

false

Members of this protein are found mostly in the Cyanobacteria, but also in the Planctomycetes. DevB from Anabaena sp. (strain PCC 7120) is partially characterised as a membrane fusion protein of the DevBCA ABC exporter, probably a glycolipid exporter required for heterocyst formation [ , , ]. Most Cyanobacteria have on...

[]

0

[ "NCBIFAM" ]

[ "TIGR02971" ]

[ "heterocyst_DevB" ]

[ 1358 ]

1

[ "GP" ]

[ "GenProp0649" ]

[ "GP:GenProp0649" ]

1

[]

0

[ "PUB00007908", "PUB00034607", "PUB00062377" ]

[ "9570404", "11371545", "9767151" ]

[ "The DevBCA exporter is essential for envelope formation in heterocysts of the cyanobacterium Anabaena sp. strain PCC 7120.", "NtcA-dependent expression of the devBCA operon, encoding a heterocyst-specific ATP-binding cassette transporter in Anabaena spp.", "Sequence and mutational analysis of the devBCA gene c...

[ 1998, 2001, 1998 ]

3

[]

0

null

[ "Bacteria", "hydrothermal vent metagenome" ]

[ 1357, 1 ]

2

[]

0

true

Family

ABC transporter, membrane fusion protein, DevB type

ABC_heterocyst_DevB

4

IPR014316

14,316

Trimethylamine N-oxide reductase system, TorE

TMAO_TorE

Family

231

false

Members of this small, apparent transmembrane protein are designated TorE and occur in operons for the trimethylamine N-oxide (TMAO) reductase system. Members are closely related to the NapE protein of the related periplasmic nitrate reductase system. It may be that TorE is an integral membrane subunit of a complex wit...

[]

0

[ "NCBIFAM" ]

[ "TIGR02972" ]

[ "TMAO_torE" ]

[ 231 ]

1

[]

0

[]

0

[]

0

[ "IPR010649" ]

[]

1

0

1

[ "Gammaproteobacteria" ]

[ 231 ]

1

[]

0

true

Family

Trimethylamine N-oxide reductase system, TorE

TMAO_TorE

6

IPR014317

14,317

Transcription activator PspF

Transcription_activator_PspF

Family

3,096

false

Members of this protein are PspF, the sigma-54-dependent transcriptional activator of the phage shock protein (psp) operon, found in Escherichia coli and numerous other species. The psp operon is induced by a number of stress conditions, including heat shock, ethanol and filamentous phage infection.

[]

0

[ "NCBIFAM" ]

[ "TIGR02974" ]

[ "phageshock_pspF" ]

[ 3096 ]

1

[ "GP" ]

[ "GenProp0648" ]

[ "GP:GenProp0648" ]

1

[ "2bjv", "2bjw", "2c96", "2c98", "2c99", "2c9c", "2vii", "4qnm", "4qnr", "4qos", "5nss", "7qv9", "9q90", "9q91", "9q92", "9q93", "9q94", "9q95", "9q97", "9q98" ]

20

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 3085, 11 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Transcription activator PspF

Transcription_activator_PspF

9

IPR014318

14,318

Phage shock protein, PspG

Phageshock_PspG

Family

1,271

false

This protein previously was designated yjbO in Escherichia coli, and it is also known as envelope stress response protein PspG. It is found only in genomes that have the phage shock operon (psp), but it is only rarely encoded near other psp genes. The psp regulon is upregulated in response to a number of stress conditi...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09583", "TIGR02975" ]

[ "Phageshock_PspG", "phageshock_pspG" ]

[ 1271, 1218 ]

2

[ "GP" ]

[ "GenProp0648" ]

[ "GP:GenProp0648" ]

1

[]

0

[ "PUB00034602" ]

[ "15485810" ]

[ "Identification of a new member of the phage shock protein response in Escherichia coli, the phage shock protein G (PspG)." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Myoviridae sp. ct8aR17" ]

[ 1270, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Phage shock protein, PspG

Phageshock_PspG

1

IPR014320

14,320

Phage shock protein, PspC

Phageshock_PspC

Family

2,550

false

All members of this protein are the phage shock protein PspC [ ]. The phage shock regulon is restricted to the Proteobacteria and somewhat sparsely distributed there. It is expressed, under positive control of a sigma-54-dependent transcription factor; PspF, which binds and is modulated by PspA. Stresses that induce th...

[]

0

[ "NCBIFAM" ]

[ "TIGR02978" ]

[ "phageshock_pspC" ]

[ 2550 ]

1

[ "GP" ]

[ "GenProp0648" ]

[ "GP:GenProp0648" ]

1

[]

0

[ "PUB00034603" ]

[ "16468999" ]

[ "PspB and PspC of Yersinia enterocolitica are dual function proteins: regulators and effectors of the phage-shock-protein response." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Ecdysozoa", "metagenomes" ]

[ 2540, 2, 8 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Phage shock protein, PspC

Phageshock_PspC

1

IPR014323

14,323

Thiosulfate sulfurtransferase PspE

PspE

Family

510

false

Members of this very narrowly defined protein are active as rhodanese ( ) and are found in extended variants of the phage shock protein (psp operon) in Escherichia coli and a few closely related species [ ]. Note that the designation phage shock protein PspE has been applied, incorrectly, because in many instances the ...

[]

0

[ "NCBIFAM" ]

[ "TIGR02981" ]

[ "phageshock_pspE" ]

[ 510 ]

1

[ "GP" ]

[ "GenProp0648" ]

[ "GP:GenProp0648" ]

1

[ "2jtq", "2jtr", "2jts" ]

3

[ "PUB00034606" ]

[ "11997041" ]

[ "PspE (phage-shock protein E) of Escherichia coli is a rhodanese." ]

[ 2002 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 510 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Thiosulfate sulfurtransferase PspE

PspE

6

IPR014324

14,324

ABC transporter ATP-binding subunit, DevA type

ABC_heterocyst_DevA

Family

1,161

false

This entry represents the ATP-binding subunit DevA, found mostly in the Cyanobacteria, but also in the Planctomycetes. Cyanobacterial examples are involved in heterocyst formation, by which some fraction of members of the colony undergo a developmental change and become capable of nitrogen fixation. The ABC transporter...

[]

0

[ "NCBIFAM" ]

[ "TIGR02982" ]

[ "heterocyst_DevA" ]

[ 1161 ]

1

[ "GP" ]

[ "GenProp0649" ]

[ "GP:GenProp0649" ]

1

[]

0

[ "PUB00007908", "PUB00034607" ]

[ "9570404", "11371545" ]

[ "The DevBCA exporter is essential for envelope formation in heterocysts of the cyanobacterium Anabaena sp. strain PCC 7120.", "NtcA-dependent expression of the devBCA operon, encoding a heterocyst-specific ATP-binding cassette transporter in Anabaena spp." ]

[ 1998, 2001 ]

2

[]

0

null

[ "Bacteria", "Cladocopium goreaui" ]

[ 1160, 1 ]

2

[]

0

true

Family

ABC transporter ATP-binding subunit, DevA type

ABC_heterocyst_DevA

9

IPR014325

14,325

RNA polymerase sigma-E factor, actinobacteria

RNA_pol_sigma-E_actinobac

Family

17,564

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[ "GO:0016987" ]

[ "sigma factor activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM" ]

[ "TIGR02983" ]

[ "SigE-fam_strep" ]

[ 17564 ]

1

[]

0

[]

0

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00004848", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "8052622", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Analysis of the Streptomyces coelicolor sigE gene reveals the existence of a subfam...

[ 1988, 1992, 1986, 1994, 2015 ]

5

[ "IPR039425" ]

[]

1

0

1

[ "Actinomycetota", "metagenomes" ]

[ 17518, 46 ]

2

[]

0

true

Family

RNA polymerase sigma-E factor, actinobacteria

RNA_pol_sigma-E_actinobac

1

IPR014326

14,326

RNA polymerase sigma-70 factor, Planctomycetaceae

RNA_pol_sigma-70_Plancto

Family

399

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[]

0

[ "NCBIFAM" ]

[ "TIGR02984" ]

[ "Sig-70_plancto1" ]

[ 399 ]

1

[]

0

[]

0

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Plastid sigma factors: Their individual functions and regulation in transcription."...

[ 1988, 1992, 1986, 2015 ]

4

[]

0

null

[ "Cladocopium goreaui", "Planctomycetia", "hydrothermal vent metagenome" ]

[ 3, 394, 2 ]

3

[]

0

true

Family

RNA polymerase sigma-70 factor, Planctomycetaceae

RNA_pol_sigma-70_Plancto

6