LiteFold/InterPro · Datasets at Hugging Face

IPR014327

14,327

RNA polymerase sigma-70, Bacteroidetes type

RNA_pol_sigma70_bacteroid

Family

16,321

false

The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with th...

[]

0

[ "NCBIFAM" ]

[ "TIGR02985" ]

[ "Sig70_bacteroi1" ]

[ 16321 ]

1

[]

0

[]

0

[ "PUB00000061", "PUB00002181", "PUB00004340", "PUB00088319" ]

[ "3052291", "1597408", "3092189", "25596450" ]

[ "Structure and function of bacterial sigma factors.", "The sigma 70 family: sequence conservation and evolutionary relationships.", "Sigma factors from E. coli, B. subtilis, phage SP01, and phage T4 are homologous proteins.", "Plastid sigma factors: Their individual functions and regulation in transcription."...

[ 1988, 1992, 1986, 2015 ]

4

[]

0

null

[ "Bacteria", "Russula earlei", "metagenomes", "unclassified Caudoviricetes" ]

[ 16171, 2, 146, 2 ]

4

[]

0

true

Family

RNA polymerase sigma-70, Bacteroidetes type

RNA_pol_sigma70_bacteroid

9

IPR014328

14,328

Restriction endonuclease, type II, Alw26I/Eco31I/Esp3I

Restrct_endonuc_II_Alw26I

Family

72

false

There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit compositi...

[]

0

[ "PFAM", "NCBIFAM" ]

[ "PF09665", "TIGR02986" ]

[ "RE_Alw26IDE", "restrict_Alw26I" ]

[ 72, 35 ]

2

[]

0

[]

0

[ "PUB00034608", "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707" ]

[ "12172806", "15770420", "14576294", "11827971", "11557805", "15121719", "12665693" ]

[ "Evolutionary relationship of Alw26I, Eco31I and Esp3I, restriction endonucleases that recognise overlapping sequences.", "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between ...

[ 2002, 2005, 2003, 2002, 2001, 2004, 2003 ]

7

[]

0

null

[ "Bacteria", "Methanomethylophilus alvi", "Siphoviridae sp. ctSA812", "metagenomes" ]

[ 66, 2, 1, 3 ]

4

[]

0

true

Family

Restriction endonuclease, type II, Alw26I/Eco31I/Esp3I

Restrct_endonuc_II_Alw26I

7

IPR014329

14,329

M6 adenine DNA methyltransferase, Alw26I

M6_adenine_DNA_mtrans_Alw26I

Family

38

false

Members of this entry are the m6-adenine DNA methyltransferase protein, or a fusion protein that also carries m5 cytosine methyltransferase activity of type II restriction systems of the Alw26I/Eco31I/Esp3I family. A type II restriction endonuclease always accompanies a methyltransferase of this type from Alw26I/Eco31I...

[]

0

[ "NCBIFAM" ]

[ "TIGR02987" ]

[ "met_A_Alw26" ]

[ 38 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Siphoviridae sp. ctSA812" ]

[ 37, 1 ]

2

[]

0

true

Family

M6 adenine DNA methyltransferase, Alw26I

M6_adenine_DNA_mtrans_Alw26I

8

IPR014330

14,330

RNA-binding S4-related,YaaA

RNA-bd_S4-rel_YaaA

Family

3,333

false

YaaA has a single S4 domain ( ). It may be a ribosome maturation protein that its overexpression can restore both the growth and the sporulation defects caused by mutation of rplB, encoding ribosomal protein L2 [ ]. The S4 domain may bind RNA. Members of this protein are found almost exclusively in the Firmicutes, and ...

[]

0

[ "NCBIFAM" ]

[ "TIGR02988" ]

[ "YaaA_near_RecF" ]

[ 3333 ]

1

[]

0

[]

0

[ "PUB00089807" ]

[ "24637032" ]

[ "Enhanced expression of Bacillus subtilis yaaA can restore both the growth and the sporulation defects caused by mutation of rplB, encoding ribosomal protein L2." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Trichuris trichiura", "metagenomes" ]

[ 3321, 1, 11 ]

3

[]

0

true

Family

RNA-binding S4-related,YaaA

RNA-bd_S4-rel_YaaA

1

IPR014333

14,333

Ectoine utilization protein EutB

Ectoine_EutB

Family

990

false

Members of this entry are EutA, a predicted arylmalonate decarboxylase found in a conserved ectoine utilization operon of species that include Rhizobium loti (Mesorhizobium loti), Silicibacter pomeroyi, Agrobacterium tumefaciens, Pseudomonas putida and Sinorhizobium meliloti 1021, where it is known to be induced by ect...

[]

0

[ "NCBIFAM" ]

[ "TIGR02991" ]

[ "ectoine_eutB" ]

[ 990 ]

1

[ "GP" ]

[ "GenProp0653" ]

[ "GP:GenProp0653" ]

1

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "unclassified sequences" ]

[ 988, 2 ]

2

[]

0

true

Family

Ectoine utilization protein EutB

Ectoine_EutB

3

IPR014334

14,334

Ectoine utilization protein EutC

Ectoine_EutC

Family

857

false

Members of this protein family are EutC, a predicted arylmalonate decarboxylase found in a conserved ectoine utilization operon of species that include Sinorhizobium meliloti 1021 (where it is known to be induced by ectoine) [ ], Mesorhizobium loti, Silicibacter pomeroyi, Agrobacterium tumefaciens, and Pseudomonas puti...

[]

0

[ "NCBIFAM" ]

[ "TIGR02992" ]

[ "ectoine_eutC" ]

[ 857 ]

1

[ "GP" ]

[ "GenProp0653" ]

[ "GP:GenProp0653" ]

1

[]

0

[ "PUB00034609" ]

[ "15687193" ]

[ "Ectoine-induced proteins in Sinorhizobium meliloti include an Ectoine ABC-type transporter involved in osmoprotection and ectoine catabolism." ]

[ 2005 ]

1

[ "IPR003462" ]

[]

1

0

1

[ "Geodia barretti", "Pseudomonadati", "uncultured organism" ]

[ 1, 855, 1 ]

3

[]

0

true

Family

Ectoine utilization protein EutC

Ectoine_EutC

6

IPR014336

14,336

N-alpha-acetyl diaminobutyrate deacetylase DoeB

DoeB

Family

1,182

false

N-alpha-acetyl diaminobutyrate deacetylase DoeB (also known as EutE) is involved in the ectoine degradation pathway in Halomonas elongata. Ectoine is hydrolysed by DoeA to alpha-N-acetyl diaminobutyric acid which is then deacetylated to diaminobutyric acid by DoeB [ ].

[]

0

[ "NCBIFAM" ]

[ "TIGR02994" ]

[ "ectoine_eutE" ]

[ 1182 ]

1

[ "GP" ]

[ "GenProp0653" ]

[ "GP:GenProp0653" ]

1

[ "3na6", "6twl", "6twm" ]

3

[ "PUB00057268" ]

[ "20849449" ]

[ "A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581(T)." ]

[ 2010 ]

1

[ "IPR043795" ]

[]

1

0

1

[ "Geodia barretti", "Pseudomonadota", "unclassified sequences" ]

[ 1, 1173, 8 ]

3

[]

0

true

Family

N-alpha-acetyl diaminobutyrate deacetylase DoeB

DoeB

4

IPR014337

14,337

Ectoine/Hydroxyectoine ABC transporter, substrate-binding protein EhuB

Ectoine_EhuB

Family

3,004

false

This family represents the periplasmic substrate-binding proteins (PBPs) of ABC transport systems that are involved in the uptake of osmoprotectants (also termed compatible solutes) such as ectoine and hydroxyectoine. To counteract the efflux of water, bacteria and archaea accumulate the compatible solutes for a sustai...

[ "GO:0033294", "GO:0051470" ]

[ "ectoine binding", "ectoine transmembrane transport" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM", "CDD" ]

[ "TIGR02995", "cd01002" ]

[ "ectoine_ehuB", "PBP2_Ehub_like" ]

[ 2994, 2198 ]

2

[ "GP" ]

[ "GenProp0651" ]

[ "GP:GenProp0651" ]

1

[ "2q88", "2q89" ]

2

[ "PUB00048895", "PUB00056198" ]

[ "17996893", "11741199" ]

[ "Crystal structure of the ligand-binding protein EhuB from Sinorhizobium meliloti reveals substrate recognition of the compatible solutes ectoine and hydroxyectoine.", "The Venus flytrap of periplasmic binding proteins: an ancient protein module present in multiple drug receptors." ]

[ 2007, 1999 ]

2

[]

0

null

[ "Bacteria", "Rhizophagus irregularis", "unclassified sequences" ]

[ 2991, 1, 12 ]

3

[]

0

true

Family

Ectoine/Hydroxyectoine ABC transporter, substrate-binding protein EhuB

Ectoine_EhuB

3

IPR014339

14,339

Regulator of ribonuclease activity A, gammaproteobacteria

RraA_gpbac

Family

2,014

false

The regulator of ribonuclease activity A (RraA) family includes a number of closely related sequences from bacteria and plants. The Escherichia coli member has been characterised, and its crystal structure determined [ ]. It acts as a regulator of the endonuclease RNase E [ ] (see ) by binding to it and inhibiting RNA ...

[ "GO:0008428", "GO:0051252" ]

[ "ribonuclease inhibitor activity", "regulation of RNA metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "NCBIFAM" ]

[ "MF_00471", "TIGR02998" ]

[ "RraA", "RraA_entero" ]

[ 1986, 2014 ]

2

[]

0

[ "1q5x", "2yjt", "2yjv" ]

3

[ "PUB00017729", "PUB00017730" ]

[ "13678585", "14499605" ]

[ "RraA. a protein inhibitor of RNase E activity that globally modulates RNA abundance in E. coli.", "The X-ray structure of Escherichia coli RraA (MenG), A protein inhibitor of RNA processing." ]

[ 2003, 2003 ]

2

[ "IPR010203" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "ecological metagenomes" ]

[ 2008, 3, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Regulator of ribonuclease activity A, gammaproteobacteria

RraA_gpbac

2

IPR014340

14,340

Lipopolysaccharide export system protein LptA

LptA

Family

7,058

false

LptA is required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. May act as a chaperone that facilitates LPS transfer across the aquaeous environment of the periplasm. Interacts specifically with the lipid A domain of LPS [ , , ]. This protein is also known as LptH in Ps...

[ "GO:0001530", "GO:0015920", "GO:0042597" ]

[ "lipopolysaccharide binding", "lipopolysaccharide transport", "periplasmic space" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "NCBIFAM" ]

[ "MF_01914", "TIGR03002" ]

[ "LPS_assembly_LptA", "outer_YhbN_LptA" ]

[ 5544, 7056 ]

2

[ "GP" ]

[ "GenProp1079" ]

[ "GP:GenProp1079" ]

1

[ "2r19", "2r1a", "4uu4", "6gd5", "7qs6", "7zax", "7zed", "8bss", "8gaj", "8gak", "8gal", "8onu" ]

12

[ "PUB00028103", "PUB00043033", "PUB00053159", "PUB00053160", "PUB00053161", "PUB00053162", "PUB00053163", "PUB00053164", "PUB00053165", "PUB00053168", "PUB00151102", "PUB00151103" ]

[ "12045108", "17056748", "16357861", "10574995", "8606190", "11278265", "8809774", "9575204", "18424520", "18480051", "25735820", "25003324" ]

[ "Lipopolysaccharide endotoxins.", "Characterization of lptA and lptB, two essential genes implicated in lipopolysaccharide transport to the outer membrane of Escherichia coli.", "Advances in understanding bacterial outer-membrane biogenesis.", "The activity of a putative polyisoprenol-linked sugar translocase...

[ 2002, 2007, 2006, 1999, 1996, 2001, 1996, 1998, 2008, 2008, 2015, 2014 ]

12

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 6942, 8, 108 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Lipopolysaccharide export system protein LptA

LptA

3

IPR014341

14,341

Ectoine/hydroxyectoine ABC transporter, permease protein EhuD

Ectoine_EhuD

Family

3,013

false

Members of this entry are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain other genes of the ABC transporter and are typically found next to either ectoine utilization or ectoine biosynthesis operons.

[]

0

[ "NCBIFAM" ]

[ "TIGR03003" ]

[ "ectoine_ehuD" ]

[ 3013 ]

1

[ "GP" ]

[ "GenProp0651" ]

[ "GP:GenProp0651" ]

1

[]

0

[]

0

[ "IPR043429" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 3003, 10 ]

2

[]

0

true

Family

Ectoine/hydroxyectoine ABC transporter, permease protein EhuD

Ectoine_EhuD

6

IPR014342

14,342

Ectoine/hydroxyectoine ABC transporter, permease protein EhuC

Ectoine_EhuC

Family

2,802

false

ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems. ABC transporters minimally consist of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These can be found o...

[]

0

[ "NCBIFAM" ]

[ "TIGR03004" ]

[ "ectoine_ehuC" ]

[ 2802 ]

1

[ "GP" ]

[ "GenProp0651" ]

[ "GP:GenProp0651" ]

1

[]

0

[ "PUB00014769" ]

[ "9873074" ]

[ "Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters." ]

[ 1999 ]

1

[ "IPR043429" ]

[]

1

0

1

[ "Bacteria", "unclassified sequences" ]

[ 2791, 11 ]

2

[]

0

true

Family

Ectoine/hydroxyectoine ABC transporter, permease protein EhuC

Ectoine_EhuC

4

IPR014343

14,343

Ectoine/hydroxyectoine ABC transporter, ATP-binding protein

Ectoine_EhuA

Family

2,748

false

Members of this entry represent the ATP-binding protein of a conserved four-gene ABC transporter operon found next to ectoine utilisation operons and ectoine biosynthesis operons. Ectoine is a compatible solute that protects enzymes from high osmolarity. It is released by some species in response to hypoosmotic shock, ...

[]

0

[ "NCBIFAM" ]

[ "TIGR03005" ]

[ "ectoine_ehuA" ]

[ 2748 ]

1

[ "GP" ]

[ "GenProp0651" ]

[ "GP:GenProp0651" ]

1

[]

0

[ "PUB00004290", "PUB00014769", "PUB00017894", "PUB00017895", "PUB00017896", "PUB00017897", "PUB00017898", "PUB00017899", "PUB00025109", "PUB00026406", "PUB00043654" ]

[ "9872322", "9873074", "11421269", "1282354", "9640644", "11988180", "11470432", "11402022", "11080142", "11532960", "11421270" ]

[ "Crystal structure of the ATP-binding subunit of an ABC transporter.", "Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters.", "ABC transporters: physiology, structure and mechanism--an overview.", "ABC transporters: from microorgani...

[ 1998, 1999, 2001, 1992, 1998, 2002, 2001, 2001, 2000, 2001, 2001 ]

11

[ "IPR030679" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 2743, 5 ]

2

[]

0

true

Family

Ectoine/hydroxyectoine ABC transporter, ATP-binding protein

Ectoine_EhuA

3

IPR014344

14,344

XrtA system polysaccharide deacetylase

XrtA_polysacc_deacetyl

Family

1,423

false

Members of this entry belong to the family of polysaccharide deacetylases. All are found in species that encode the PEP-CTERM/exosortase system XrtA and are predicted to act in protein sorting in a number of Gram-negative bacteria, they are also found near the gene coding region for the XrtA homologue (also known as Ep...

[]

0

[ "NCBIFAM" ]

[ "TIGR03006" ]

[ "pepcterm_polyde" ]

[ 1423 ]

1

[ "GP" ]

[ "GenProp0652" ]

[ "GP:GenProp0652" ]

1

[]

0

[ "PUB00034422", "PUB00060405" ]

[ "16930487", "22037399" ]

[ "Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.", "Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification." ]

[ 2006, 2012 ]

2

[ "IPR045235" ]

[]

1

0

1

[ "Bacteria", "Stenosarchaea group", "unclassified sequences" ]

[ 1384, 9, 30 ]

3

[]

0

true

Family

XrtA system polysaccharide deacetylase

XrtA_polysacc_deacetyl

7

IPR014345

14,345

XrtA system polysaccharide chain length determinant

XrtA_polysacc_chain

Family

1,488

false

Members of this entry belong to the family of polysaccharide chain length determinant proteins. They are found in species that encode the PEP-CTERM/exosortase system and are predicted to act in protein sorting in a number of Gram-negative bacteria, they are also found near the epsH homologue that is the putative exosor...

[]

0

[ "NCBIFAM" ]

[ "TIGR03007" ]

[ "pepcterm_ChnLen" ]

[ 1488 ]

1

[ "GP" ]

[ "GenProp0652" ]

[ "GP:GenProp0652" ]

1

[]

0

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 1459, 29 ]

2

[]

0

true

Family

XrtA system polysaccharide chain length determinant

XrtA_polysacc_chain

3

IPR014346

14,346

Prenyl protease-related

Prenyl_protease-related

Family

529

false

Members of this protein family are fusion proteins of exosortase (N-terminal) and a CAAX prenyl protease domain (C-terminal). Members are restricted to the alpha Proteobacteria. The variant C-terminal protein sequence VPEID-CTERM occurs only in these species, often adjacent [ ]. In eukaryotes, CAAX prenyl protease cata...

[]

0

[ "NCBIFAM" ]

[ "TIGR03008" ]

[ "pepcterm_CAAX" ]

[ 529 ]

1

[]

0

[]

0

[ "PUB00060405" ]

[ "22037399" ]

[ "Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification." ]

[ 2012 ]

1

[]

[ "IPR026420" ]

0

1

0

[ "Bacteria", "Eukaryota", "Methanomicrobia", "ecological metagenomes" ]

[ 517, 2, 3, 7 ]

4

[]

0

true

Family

Prenyl protease-related

Prenyl_protease-related

7

IPR014347

14,347

Tautomerase/MIF superfamily

Tautomerase/MIF_sf

Homologous_superfamily

40,648

false

Tautomerase superfamily members have a (β-α-β)2 structure in two layers, and use a similar mechanism of action involving an amino-terminal proline as a general base in a ket-enol tautomerisation reaction [ ]. Members of this superfamily include macrophage migration inhibitory factor (MIF) and related proteins such as D...

[]

0

[ "CATHGENE3D", "SSF" ]

[ "G3DSA:3.30.429.10", "SSF55331" ]

[ "", "" ]

[ 40514, 38525 ]

2

[ "EC", "EC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.3.2", "5.3.2.-", "PWY-5642", "PWY-6550", "R-BTA-202733", "R-BTA-6798695", "R-GGA-202733", "R-GGA-6798695", "R-HSA-202733", "R-HSA-6798695", "R-HSA-8950505", "R-MMU-202733", "R-MMU-6798695", "R-RNO-202733", "R-RNO-6798695", "R-SSC-202733", "R-SSC-6798695", "R-XTR-6798695" ]

[ "EC:5.3.2", "EC:5.3.2.-", "METACYC:PWY-5642", "METACYC:PWY-6550", "REACTOME:R-BTA-202733", "REACTOME:R-BTA-6798695", "REACTOME:R-GGA-202733", "REACTOME:R-GGA-6798695", "REACTOME:R-HSA-202733", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-8950505", "REACTOME:R-MMU-202733", "REACTOME:R-MMU-679869...

18

[ "1bjp", "1ca7", "1cgq", "1dpt", "1fim", "1gcz", "1gd0", "1gif", "1gyj", "1gyx", "1gyy", "1hfo", "1ljt", "1mff", "1mfi", "1mif", "1mww", "1otf", "1otg", "1p1g", "1s0y", "1u9d", "1uiz", "2aag", "2aaj", "2aal", "2flt", "2flz", "2fm7", "2gdg", "2ooh", "2oow"...

293

[ "PUB00007676", "PUB00019310", "PUB00025426", "PUB00034437", "PUB00034439" ]

[ "12051677", "8547259", "12356301", "15225126", "16628200" ]

[ "The 4-oxalocrotonate tautomerase family of enzymes: how nature makes new enzymes using a beta-alpha-beta structural motif.", "Enzymatic ketonization of 2-hydroxymuconate: specificity and mechanism investigated by the crystal structures of two isomerases.", "The crystal structure of YdcE, a 4-oxalocrotonate tau...

[ 2002, 1996, 2002, 2004, 2006 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Sym plasmid", "unclassified sequences" ]

[ 400, 31017, 8982, 2, 247 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 15, 6, 2, 1, 13, 6, 1, 8, 12, 5 ]

10

true

Homologous_superfamily

Tautomerase/MIF superfamily

Tautomerase/MIF_sf

2

IPR014349

14,349

Rieske iron-sulphur protein

Rieske_Fe-S_prot

Family

29,417

false

The Rieske subunit can be found in the Ubiquinol-cytochrome c reductase (bc1 complex or complex III) or the cytochrome b6f complex. The Rieske subunit acts by binding either a ubiquinol or plastoquinol anion, transferring an electron to the 2Fe-2S cluster, then releasing the electron to the cytochrome c or cytochrome f...

[ "GO:0051537" ]

[ "2 iron, 2 sulfur cluster binding" ]

[ "molecular_function" ]

1

[ "PANTHER" ]

[ "PTHR10134" ]

[ "" ]

[ 29417 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "7.1.1", "R-BTA-611105", "R-BTA-9865881", "R-CEL-9865881", "R-DME-611105", "R-DME-9865881", "R-DRE-9865881", "R-GGA-611105", "R-GGA-9865881", "R-HSA-611105", "R-HSA-9865881", "R-MMU-611105", "R-MMU-9865881", "R-RNO-611105", "R-RNO-9865881", "R-SCE-611105", "R-SCE-9865878", "R-SCE-9...

[ "EC:7.1.1", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-9865881", "REACTOME:R-CEL-9865881", "REACTOME:R-DME-611105", "REACTOME:R-DME-9865881", "REACTOME:R-DRE-9865881", "REACTOME:R-GGA-611105", "REACTOME:R-GGA-9865881", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-9865881", "REACTOME:R-MMU-611105", ...

21

[ "1bcc", "1be3", "1bgy", "1ezv", "1jm1", "1kb9", "1kyo", "1l0l", "1l0n", "1ntk", "1ntm", "1ntz", "1nu1", "1nyk", "1p84", "1pp9", "1ppj", "1q90", "1qcr", "1rfs", "1rie", "1sqb", "1sqp", "1sqq", "1sqv", "1sqx", "1vf5", "1zrt", "2a06", "2bcc", "2d2c", "2e74"...

269

[ "PUB00001341", "PUB00001342", "PUB00002441", "PUB00004558", "PUB00025173", "PUB00032072", "PUB00093900" ]

[ "2986972", "3004982", "2820981", "1391772", "11250197", "14526088", "28754840" ]

[ "The primary structure of the iron-sulfur subunit of ubiquinol-cytochrome c reductase from Neurospora, determined by cDNA and gene sequencing.", "Nucleotide sequence and transcription of the fbc operon from Rhodopseudomonas sphaeroides. Evaluation of the deduced amino acid sequences of the FeS protein, cytochrome...

[ 1985, 1986, 1987, 1992, 2001, 2003, 2017 ]

7

[]

[ "IPR014067", "IPR023960" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 667, 21170, 7027, 553 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 11, 1, 1, 6, 4, 1, 1, 7, 3, 1, 1, 20 ]

12

true

Family

Rieske iron-sulphur protein

Rieske_Fe-S_prot

1

IPR014352

14,352

FERM/acyl-CoA-binding protein superfamily

FERM/acyl-CoA-bd_prot_sf

Homologous_superfamily

111,285

false

This superfamily represents a structural domain with a core structure consisting of a 3-helical closed bundle with a left-handed twist, in an up-and-down arrangement. This structural motif occurs as subdomain 2 within FERM domains, as well as in acyl-CoA-binding proteins. The FERM domain (band F ezrin-radixin-moesin ho...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:1.20.80.10" ]

[ "" ]

[ 111285 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-373752", "R-BTA-390918", "R-BTA-6794361", "R-BTA-77289", "R-CEL-182971", "R-CEL-2029482", "R-CEL-2453902", "R-CEL-354192", "R-CEL-354194", "R-CEL-375165", "R-CEL-390918", "R-CEL-3928662", "R-CEL-418885", "R-CEL-4420097", "R-CEL-5663213", "R-CEL-5673001", "R-CEL-5675221", "R-...

[ "REACTOME:R-BTA-373752", "REACTOME:R-BTA-390918", "REACTOME:R-BTA-6794361", "REACTOME:R-BTA-77289", "REACTOME:R-CEL-182971", "REACTOME:R-CEL-2029482", "REACTOME:R-CEL-2453902", "REACTOME:R-CEL-354192", "REACTOME:R-CEL-354194", "REACTOME:R-CEL-375165", "REACTOME:R-CEL-390918", "REACTOME:R-CEL-3...

210

[ "1aca", "1e5w", "1ef1", "1gc6", "1gc7", "1gg3", "1h4r", "1hb6", "1hb8", "1hbk", "1isn", "1j19", "1mix", "1miz", "1mk7", "1mk9", "1ni2", "1nti", "1nvl", "1sgh", "1st7", "1y19", "2abd", "2aeh", "2al6", "2cb8", "2cop", "2cqu", "2d10", "2d11", "2d2q", "2ems"...

203

[ "PUB00013213", "PUB00021736" ]

[ "10847681", "11491287" ]

[ "Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain.", "Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein." ]

[ 2000, 2001 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Viruses", "metagenomes" ]

[ 2893, 108316, 8, 8, 60 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 36, 55, 569, 74, 266, 222, 2, 10, 266, 1, 1, 94 ]

12

true

Homologous_superfamily

FERM/acyl-CoA-binding protein superfamily

FERM/acyl-CoA-bd_prot_sf

2

IPR014353

14,353

Membrane-bound alcohol dehydrogenase, cytochrome c subunit

Membr-bd_ADH_cyt_c

Family

8,853

false

In Acetobacter polyoxogenes, this tri-haem binding cytochrome c is one the two subunits of the membrane-bound alcohol dehydrogenase (ADH) [ ]. In other species of the genera Acetobacter, Gluconobacter, and Erwinia, the cytochrome c is one of the three subunits of the membrane-bound gluconate dehydrogenase (GADH) [ ], w...

[ "GO:0005506", "GO:0016614", "GO:0020037", "GO:0016020" ]

[ "iron ion binding", "oxidoreductase activity, acting on CH-OH group of donors", "heme binding", "membrane" ]

[ "molecular_function", "molecular_function", "molecular_function", "cellular_component" ]

4

[ "PIRSF" ]

[ "PIRSF000018" ]

[ "Mb_ADH_cyt_c" ]

[ 8853 ]

1

[ "EC", "METACYC" ]

[ "1.1.5.5", "PWY-6873" ]

[ "EC:1.1.5.5", "METACYC:PWY-6873" ]

2

[ "7w2j", "7wsq", "8gy2", "8gy3", "8hdd", "8jej", "8jek", "8k6j", "8k6k", "8xcm", "8xcn" ]

11

[ "PUB00015916", "PUB00015949" ]

[ "9352901", "2001402" ]

[ "Cloning and expression of a gene cluster encoding three subunits of membrane-bound gluconate dehydrogenase from Erwinia cypripedii ATCC 29267 in Escherichia coli.", "Cloning and sequencing of the gene cluster encoding two subunits of membrane-bound alcohol dehydrogenase from Acetobacter polyoxogenes." ]

[ 1997, 1991 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 8822, 9, 22 ]

3

[]

0

true

Family

Membrane-bound alcohol dehydrogenase, cytochrome c subunit

Membr-bd_ADH_cyt_c

2

IPR014358

14,358

Enoyl-[acyl-carrier-protein] reductase (NADH)

Enoyl-ACP_Rdtase_NADH

Family

22,323

false

This entry contains enoyl-[acyl-carrier-protein] reductases ( ). They are components of the type II (dissociable) fatty acid synthase system and catalyse the terminal reaction in the fatty acid elongation cycle. They belong to the short-chain dehydrogenases/reductases (SDR) domain superfamily [ , , ]. Crystal structure...

[ "GO:0004318", "GO:0006633" ]

[ "enoyl-[acyl-carrier-protein] reductase (NADH) activity", "fatty acid biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF", "PANTHER", "CDD" ]

[ "PIRSF000094", "PTHR43159", "cd05372" ]

[ "Enoyl-ACP_rdct", "", "ENR_SDR" ]

[ 20248, 22287, 17166 ]

3

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.3.1.9", "PWY-5971", "PWY-5973", "PWY-5989", "PWY-6282", "PWY-6519", "PWY-7663", "PWY-7664", "PWY-7858", "PWY-8173", "PWY-8174", "PWY-8175", "PWY-8203", "PWYG-321" ]

[ "EC:1.3.1.9", "METACYC:PWY-5971", "METACYC:PWY-5973", "METACYC:PWY-5989", "METACYC:PWY-6282", "METACYC:PWY-6519", "METACYC:PWY-7663", "METACYC:PWY-7664", "METACYC:PWY-7858", "METACYC:PWY-8173", "METACYC:PWY-8174", "METACYC:PWY-8175", "METACYC:PWY-8203", "METACYC:PWYG-321" ]

14

[ "1bvr", "1c14", "1cwu", "1d7o", "1d8a", "1dfg", "1dfh", "1dfi", "1eno", "1enp", "1eny", "1enz", "1i2z", "1i30", "1lx6", "1lxc", "1mfp", "1nhg", "1nhw", "1nnu", "1p44", "1p45", "1qg6", "1qsg", "1uh5", "1ulu", "1v35", "1vrw", "1zid", "1zsn", "1zw1", "1zxb"...

279

[ "PUB00000419", "PUB00021526", "PUB00022895", "PUB00023818", "PUB00027148", "PUB00027319", "PUB00027735", "PUB00027752", "PUB00027779", "PUB00027780" ]

[ "7742302", "8535786", "9417034", "10595560", "12109908", "12699381", "10398587", "10493822", "12604213", "12604210" ]

[ "Short-chain dehydrogenases/reductases (SDR).", "Common themes in redox chemistry emerge from the X-ray structure of oilseed rape (Brassica napus) enoyl acyl carrier protein reductase.", "Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.", "Molecular basis for triclosan ...

[ 1995, 1995, 1998, 1999, 2002, 2003, 1999, 1999, 2003, 2003 ]

10

[ "IPR002347" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "environmental samples", "unclassified sequences" ]

[ 20089, 1783, 3, 448 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 3, 1, 4, 23 ]

4

true

Family

Enoyl-[acyl-carrier-protein] reductase (NADH)

Enoyl-ACP_Rdtase_NADH

9

IPR014359

14,359

Ketol-acid reductoisomerase, prokaryotic

KARI_prok

Family

17,758

false

Ketol-acid reductoisomerases (KARI) catalyses two steps in the biosynthesis of branched-chain amino acids. The reaction involves an Mg2+ dependent alkyl migration followed by an NADPH-dependent reduction of the 2-keto group. There are two groups of KARI enzymes: class I is a short form found in fungi and most bacteria,...

[ "GO:0004455", "GO:0050661", "GO:0009082" ]

[ "ketol-acid reductoisomerase activity", "NADP binding", "branched-chain amino acid biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF000116" ]

[ "IlvC_gammaproteo" ]

[ 17758 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "1.1.1.86", "PWY-5103", "PWY-7111" ]

[ "EC:1.1.1.86", "METACYC:PWY-5103", "METACYC:PWY-7111" ]

3

[ "1np3", "4kqw", "4kqx", "4tsk", "4xdy", "4xdz", "4xeh", "4xiy", "4ypo", "5w3k", "5yeq", "6aqj", "6bul", "6c55", "6c5n", "6jx2", "6l2i", "6l2k", "6l2r", "6l2s", "6l2z", "6vo2", "7ke2", "7kh7", "7lat", "7q03", "7q07", "7rdu", "8cy8", "8ep7", "8k32", "8pru"...

40

[ "PUB00034453", "PUB00036035" ]

[ "16322583", "15272168" ]

[ "The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution.", "Facile crystallization of Escherichia coli ketol-acid reductoisomerase." ]

[ 2005, 2004 ]

2

[ "IPR013023" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 795, 16588, 44, 331 ]

4

[]

0

true

Family

Ketol-acid reductoisomerase, prokaryotic

KARI_prok

6

IPR014362

14,362

Glutamate dehydrogenase

Glu_DH

Family

30,853

false

This entry represents glutamate dehydrogenases (GDH). The tertiary structure have been solved for the GDHs from Thermotoga maritima and Pyrococcus furiosus, both of which are thermostable because of an ion-pair network in the hinge region [ ]. Some GDHs are NADP-specific, such as GdhA from Escherichia coli, which catal...

[ "GO:0016639" ]

[ "oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF000185" ]

[ "Glu_DH" ]

[ 30853 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.4.1", "R-DDI-2151201", "R-DDI-8964539", "R-DDI-9837999" ]

[ "EC:1.4.1", "REACTOME:R-DDI-2151201", "REACTOME:R-DDI-8964539", "REACTOME:R-DDI-9837999" ]

4

[ "1aup", "1b26", "1b3b", "1bgv", "1bvu", "1euz", "1gtm", "1hrd", "1hwy", "1k89", "1l1f", "1nqt", "1nr1", "1nr7", "1v9l", "2bma", "2tmg", "2yfh", "2yfq", "3aoe", "3aog", "3etd", "3ete", "3etg", "3jcz", "3jd0", "3jd1", "3jd2", "3jd3", "3jd4", "3k8z", "3k92"...

120

[ "PUB00023488", "PUB00082609", "PUB00082610", "PUB00082611" ]

[ "9654452", "235298", "241744", "1952936" ]

[ "Engineering activity and stability of Thermotoga maritima glutamate dehydrogenase. I. Introduction of a six-residue ion-pair network in the hinge region.", "Glutamate dehydrogenase from Escherichia coli: induction, purification and properties of the enzyme.", "Glutamate dehydrogenase from Escherichia coli: pur...

[ 1998, 1975, 1975, 1991 ]

4

[ "IPR006095" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 1414, 23684, 5451, 6, 298 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"...

[ 12, 1, 3, 1, 6, 1, 4, 2, 1, 10 ]

10

true

Family

Glutamate dehydrogenase

Glu_DH

8

IPR014367

14,367

Cytochrome c oxidase subunit VII, budding yeast

Cox7_yeast

Family

26

false

Cox7 is the subunit VII of cytochrome c oxidase (Complex IV). Cytochrome c oxidase catalyses the terminal step in the electron transport chain involved in cellular respiration [ ].

[ "GO:0006123", "GO:0005739" ]

[ "mitochondrial electron transport, cytochrome c to oxygen", "mitochondrion" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF000282" ]

[ "COX7" ]

[ 26 ]

1

[]

0

[ "6giq", "6hu9", "6t0b", "6t15", "7z10", "8dh6", "8e7s", "8ec0", "9bpb", "9etz" ]

10

[ "PUB00074941" ]

[ "2168889" ]

[ "Yeast cytochrome c oxidase subunit VII is essential for assembly of an active enzyme. Cloning, sequencing, and characterization of the nuclear-encoded gene." ]

[ 1990 ]

1

[]

0

null

[ "Saccharomycotina" ]

[ 26 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Cytochrome c oxidase subunit VII, budding yeast

Cox7_yeast

5

IPR014368

14,368

Cytochrome c oxidase, subunit VIIa, fungal

Cyt_c_oxidase_su7a_fun

Family

858

false

Cytochrome c oxidase ( ) is an oligomeric enzymatic complex which is a component of the respiratory chain complex and is involved in the transfer of electrons from cytochrome c to oxygen [ , ]. In fungi (as in other eukaryotes) this enzyme complex is located in the mitochondrial inner membrane. In eukaryotes, in additi...

[ "GO:0006123" ]

[ "mitochondrial electron transport, cytochrome c to oxygen" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF000283" ]

[ "COX9" ]

[ 858 ]

1

[]

0

[ "6giq", "6hu9", "6t0b", "6t15", "6ymx", "6ymy", "7z10", "8c8q", "8dh6", "8e7s", "8ec0", "8q1b", "8ucj", "8uck", "8ucl", "8ucm", "8ucn", "8uco", "8ucp", "9bpb", "9etz" ]

21

[ "PUB00000581", "PUB00101096", "PUB00154382" ]

[ "6307356", "30598554", "36797353" ]

[ "Structure of cytochrome c oxidase.", "Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc<sub>1</sub>.", "Cryo-EM structure and function of S. pombe complex IV with bound respiratory supercomplex factor." ]

[ 1983, 2019, 2023 ]

3

[]

0

null

[ "Fungi" ]

[ 858 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Cytochrome c oxidase, subunit VIIa, fungal

Cyt_c_oxidase_su7a_fun

6

IPR014369

14,369

Glycine/Sarcosine N-methyltransferase

Gly/Sar_N_MeTrfase

Family

2,103

false

Glycine/Sarcosine N-methyltransferase catalyses the methylation of glycine, sarcosine and dimethylglycine to sarcosine, dimethylglycine and betaine, respectively, with S-adenosylmethionine (AdoMet) acting as the methyl donor [ , , , ]. Methyltransferases (EC [ec:2.1.1.-]) constitute an important class of enzymes presen...

[ "GO:0017174" ]

[ "glycine N-methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "PROFILE", "PANTHER" ]

[ "PIRSF000385", "PS51600", "PTHR16458" ]

[ "Gly_N-mtase", "SAM_GNMT", "" ]

[ 917, 1823, 1986 ]

3

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1", "R-HSA-2408508", "R-HSA-389661", "R-HSA-9925561", "R-MMU-389661", "R-RNO-389661" ]

[ "EC:2.1.1", "REACTOME:R-HSA-2408508", "REACTOME:R-HSA-389661", "REACTOME:R-HSA-9925561", "REACTOME:R-MMU-389661", "REACTOME:R-RNO-389661" ]

6

[ "1bhj", "1d2c", "1d2g", "1d2h", "1kia", "1nbh", "1nbi", "1r74", "1r8x", "1r8y", "1xva", "2azt", "2idj", "2idk", "3thr", "3ths", "5gwx", "5h02", "5hii", "5hij", "5hik", "5hil", "5him" ]

23

[ "PUB00006319", "PUB00016741", "PUB00022593", "PUB00047053", "PUB00054125", "PUB00057957", "PUB00057958", "PUB00058042" ]

[ "7897657", "8281755", "15340920", "17660255", "12826405", "16225687", "21858014", "17019606" ]

[ "Universal catalytic domain structure of AdoMet-dependent methyltransferases.", "Mammalian glycine N-methyltransferases. Comparative kinetic and structural properties of the enzymes from human, rat, rabbit and pig livers.", "Glycine N-methyltransferases: a comparison of the crystal structures and kinetic proper...

[ 1995, 1993, 2004, 2007, 2003, 2005, 2011, 2006 ]

8

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 12, 718, 1361, 12 ]

4

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 4, 3, 4 ]

5

true

Family

Glycine/Sarcosine N-methyltransferase

Gly/Sar_N_MeTrfase

1

IPR014371

14,371

Sterol O-acyltransferase, ACAT/DAG/ARE types

Oat_ACAT_DAG_ARE

Family

10,775

false

This entry represents a sterol O-acyltransferase, ACAT/DAG/ARE types. Please see the following relevant references [ , , , ].

[ "GO:0008374" ]

[ "O-acyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF000439", "PTHR10408" ]

[ "Oat_ACAT_DAG_ARE", "" ]

[ 8346, 10773 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.1", "R-DDI-1482883", "R-DDI-6798695", "R-DDI-75109", "R-HSA-1482883", "R-HSA-6798695", "R-HSA-75109", "R-HSA-8964038", "R-MMU-1482883", "R-MMU-6798695", "R-MMU-75109", "R-MMU-8964038", "R-RNO-1482883", "R-RNO-6798695", "R-RNO-75109", "R-RNO-8964038" ]

[ "EC:2.3.1", "REACTOME:R-DDI-1482883", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-75109", "REACTOME:R-HSA-1482883", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-75109", "REACTOME:R-HSA-8964038", "REACTOME:R-MMU-1482883", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-75109", "REACTOME:R-MMU-8964038", ...

16

[ "6l47", "6l48", "6p2j", "6p2p", "6vp0", "6vum", "6vyi", "6vz1", "7n6q", "7n6r", "8esm", "8etm", "9vjm", "9vjx", "9vk0", "9vk1" ]

16

[ "PUB00005220", "PUB00027899", "PUB00027908", "PUB00027939" ]

[ "8650549", "11353332", "11544264", "11489845" ]

[ "Sterol esterification in yeast: a two-gene process.", "Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2.", "The enzymes of neutral lipid synthesis.", "Transcriptional regulation of the two sterol esterification genes in the yeast Saccharomyces cerevisiae." ]

[ 1996, 2001, 2001, 2001 ]

4

[ "IPR004299" ]

[ "IPR027251", "IPR030687" ]

1

2

0

[ "Eukaryota", "bird metagenome" ]

[ 10773, 2 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 3, 12, 3, 8, 8, 3, 3, 16, 2, 2, 20 ]

12

true

Family

Sterol O-acyltransferase, ACAT/DAG/ARE types

Oat_ACAT_DAG_ARE

5

IPR014375

14,375

Protein kinase C, alpha/beta/gamma types

Protein_kinase_C_a/b/g

Family

5,270

false

Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substra...

[ "GO:0004697", "GO:0005524", "GO:0008270", "GO:0006468" ]

[ "diacylglycerol-dependent serine/threonine kinase activity", "ATP binding", "zinc ion binding", "protein phosphorylation" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "PIRSF" ]

[ "PIRSF000550" ]

[ "PKC_alpha" ]

[ 5270 ]

1

[ "EC", "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACT...

[ "2.7.11.13", "GenProp2096", "R-BTA-114516", "R-BTA-1169091", "R-BTA-416993", "R-BTA-4419969", "R-BTA-5099900", "R-BTA-5218921", "R-BTA-5668599", "R-BTA-76005", "R-CEL-111933", "R-CEL-114516", "R-CEL-1169091", "R-CEL-1433559", "R-CEL-2179392", "R-CEL-3000170", "R-CEL-399997", "R-CEL...

[ "EC:2.7.11.13", "GP:GenProp2096", "REACTOME:R-BTA-114516", "REACTOME:R-BTA-1169091", "REACTOME:R-BTA-416993", "REACTOME:R-BTA-4419969", "REACTOME:R-BTA-5099900", "REACTOME:R-BTA-5218921", "REACTOME:R-BTA-5668599", "REACTOME:R-BTA-76005", "REACTOME:R-CEL-111933", "REACTOME:R-CEL-114516", "REA...

103

[ "3pfq", "8se1", "8se2", "8se3", "8se4" ]

5

[ "PUB00005115", "PUB00015362", "PUB00020114", "PUB00034898", "PUB00034899" ]

[ "3291115", "12368087", "12471243", "15078142", "15320712" ]

[ "The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.", "Evolution of protein kinase signaling from yeast to man.", "The protein kinase complement of the human genome.", "High-throughput structural biology in drug discovery: protein kinases.", "Creating chemical dive...

[ 1988, 2002, 2002, 2004, 2004 ]

5

[]

0

null

[ "Opisthokonta" ]

[ 5270 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 10, 5, 10, 6, 23 ]

6

true

Family

Protein kinase C, alpha/beta/gamma types

Protein_kinase_C_a/b/g

4

IPR014376

14,376

Protein kinase C, delta/epsilon/eta/theta types

Prot_kin_PKC_delta

Family

6,586

false

This entry represents the novel protein kinase C (nPKC) family. The N-terminal regulatory domain of nPKC consists of a C2 domain follows by a double C1 domain (C1A and C1B). The C2 domain does not respond to calcium which makes nPKC diacylglycerol-sensitive but calcium-independent [ , , ]. PKC is a family of serine- an...

[ "GO:0004697", "GO:0006468" ]

[ "diacylglycerol-dependent serine/threonine kinase activity", "protein phosphorylation" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF000551" ]

[ "PKC_delta" ]

[ 6586 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.11.13", "R-CEL-111465", "R-CEL-111933", "R-CEL-114508", "R-CEL-1489509", "R-CEL-202424", "R-CEL-2029485", "R-CEL-2871837", "R-CEL-373752", "R-CEL-5218921", "R-CEL-5607764", "R-CEL-6798695", "R-CEL-9648002", "R-DME-111465", "R-DME-111933", "R-DME-114508", "R-DME-1250196", "R-DM...

[ "EC:2.7.11.13", "REACTOME:R-CEL-111465", "REACTOME:R-CEL-111933", "REACTOME:R-CEL-114508", "REACTOME:R-CEL-1489509", "REACTOME:R-CEL-202424", "REACTOME:R-CEL-2029485", "REACTOME:R-CEL-2871837", "REACTOME:R-CEL-373752", "REACTOME:R-CEL-5218921", "REACTOME:R-CEL-5607764", "REACTOME:R-CEL-6798695...

79

[]

0

[ "PUB00063559", "PUB00063560", "PUB00063561", "PUB00063562", "PUB00063563", "PUB00063648", "PUB00063649", "PUB00063650" ]

[ "199594", "7358670", "9601053", "17661083", "9792904", "19033211", "1411571", "12359062" ]

[ "Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain.", "Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turn...

[ 1977, 1980, 1998, 2007, 1998, 2009, 1992, 2002 ]

8

[]

[ "IPR027264", "IPR027274", "IPR027431", "IPR027436" ]

0

4

0

[ "Opisthokonta" ]

[ 6586 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 17, 6, 9, 16, 18 ]

6

true

Family

Protein kinase C, delta/epsilon/eta/theta types

Prot_kin_PKC_delta

8

IPR014379

14,379

6-phosphofructo-2-kinase Pfk27

Pfk27

Family

14

false

When compared with bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases, members of this group show similarities only to the kinase domains ( ). The protein encoded by PFK27 in Saccharomyces cerevisiae was shown to be a second inducible 6-phosphofructo-2-kinase [ ]. Expression of Pfk27 was induced by gluc...

[ "GO:0003873", "GO:0006110" ]

[ "6-phosphofructo-2-kinase activity", "regulation of glycolytic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF000711" ]

[ "PFK27" ]

[ 14 ]

1

[ "REACTOME" ]

[ "R-SCE-9634600" ]

[ "REACTOME:R-SCE-9634600" ]

1

[]

0

[ "PUB00027723" ]

[ "8861205" ]

[ "Cloning of a second gene encoding 5-phosphofructo-2-kinase in yeast, and characterization of mutant strains without fructose-2,6-bisphosphate." ]

[ 1996 ]

1

[ "IPR003094" ]

[]

1

0

1

[ "Saccharomycetaceae" ]

[ 14 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

6-phosphofructo-2-kinase Pfk27

Pfk27

9

IPR014383

14,383

RNA-directed RNA polymerase, phytoreovirus

RNA-dir_pol_phytoreovirus

Family

12

false

This entry represents a RNA-directed RNA polymerase, Phytoreovirus type. RNA-directed RNA polymerase (RdRp) ( ) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage [ , ]. It catalyses synthesis of the RNA strand complementary to a given RNA template, but the precise molecular ...

[ "GO:0019079" ]

[ "viral genome replication" ]

[ "biological_process" ]

1

[ "PFAM", "PIRSF" ]

[ "PF27669", "PIRSF000822" ]

[ "RNA-dir_pol_phytoreovirus", "RdRPol_RDV" ]

[ 12, 2 ]

2

[ "EC" ]

[ "2.7.7.48" ]

[ "EC:2.7.7.48" ]

1

[]

0

[ "PUB00009392", "PUB00030617", "PUB00033622", "PUB00033623", "PUB00033624", "PUB00033625" ]

[ "9878607", "9309225", "2759231", "8709232", "11531403", "10827187" ]

[ "Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure.", "Structure of the RNA-dependent RNA polymerase of poliovirus.", "Tentative identification of RNA-dependent RNA polymerases of dsRNA viruses and their relat...

[ 1998, 1997, 1989, 1996, 2001, 2000 ]

6

[]

0

null

[ "Riboviria" ]

[ 12 ]

1

[]

0

true

Family

RNA-directed RNA polymerase, phytoreovirus

RNA-dir_pol_phytoreovirus

5

IPR014384

14,384

RNA-directed RNA polymerase, orthobunyavirus

RNA-dir_pol_orthobunyavirus

Family

36

false

RNA-directed RNA polymerase (RdRp) ( ) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage [ , ]. It catalyses synthesis of the RNA strand complementary to a given RNA template, but the precise molecular mechanism remains unclear. The postulated RNA replication process is a tw...

[]

0

[ "PIRSF" ]

[ "PIRSF000824" ]

[ "L_OrthobunV" ]

[ 36 ]

1

[ "EC" ]

[ "2.7.7.48" ]

[ "EC:2.7.7.48" ]

1

[ "5amq", "5amr", "6z6b", "6z6g", "6z8k", "7ori", "7orj", "7ork", "7orl", "7orm", "7orn", "7oro" ]

12

[ "PUB00009392", "PUB00030617", "PUB00033622", "PUB00033623", "PUB00033624", "PUB00033625" ]

[ "9878607", "9309225", "2759231", "8709232", "11531403", "10827187" ]

[ "Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure.", "Structure of the RNA-dependent RNA polymerase of poliovirus.", "Tentative identification of RNA-dependent RNA polymerases of dsRNA viruses and their relat...

[ 1998, 1997, 1989, 1996, 2001, 2000 ]

6

[]

0

null

[ "Orthobunyavirus" ]

[ 36 ]

1

[]

0

true

Family

RNA-directed RNA polymerase, orthobunyavirus

RNA-dir_pol_orthobunyavirus

9

IPR014385

14,385

RNA-directed RNA polymerase, phlebovirus

RNA-dir_pol_phlebovirus

Family

152

false

RNA-directed RNA polymerase (RdRp) ( ) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage [ , ]. It catalyses synthesis of the RNA strand complementary to a given RNA template, but the precise molecular mechanism remains unclear. The postulated RNA replication process is a tw...

[ "GO:0001882", "GO:0003968", "GO:0019079" ]

[ "nucleoside binding", "RNA-directed RNA polymerase activity", "viral genome replication" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF000826" ]

[ "L_PhleboV" ]

[ 152 ]

1

[ "EC" ]

[ "2.7.7.48" ]

[ "EC:2.7.7.48" ]

1

[ "9qtb" ]

1

[ "PUB00009392", "PUB00030617", "PUB00033622", "PUB00033623", "PUB00033624", "PUB00033625" ]

[ "9878607", "9309225", "2759231", "8709232", "11531403", "10827187" ]

[ "Analysis of RNA-dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure.", "Structure of the RNA-dependent RNA polymerase of poliovirus.", "Tentative identification of RNA-dependent RNA polymerases of dsRNA viruses and their relat...

[ 1998, 1997, 1989, 1996, 2001, 2000 ]

6

[]

0

null

[ "Phenuiviridae" ]

[ 152 ]

1

[]

0

true

Family

RNA-directed RNA polymerase, phlebovirus

RNA-dir_pol_phlebovirus

1

IPR014387

14,387

CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote

CDP_diag_ino_3_P_euk

Family

2,846

false

This entry represents a CDP-diacylglycerol-inositol 3-phosphatidyltransferase.

[]

0

[ "PIRSF" ]

[ "PIRSF000848" ]

[ "CDP_diag_ino_3_P" ]

[ 2846 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.8.11", "PWY-6351", "PWY-6352", "PWY-7625", "R-DME-1483226", "R-HSA-1483226", "R-MMU-1483226", "R-RNO-1483226", "R-SCE-1483226", "R-SPO-1483226" ]

[ "EC:2.7.8.11", "METACYC:PWY-6351", "METACYC:PWY-6352", "METACYC:PWY-7625", "REACTOME:R-DME-1483226", "REACTOME:R-HSA-1483226", "REACTOME:R-MMU-1483226", "REACTOME:R-RNO-1483226", "REACTOME:R-SCE-1483226", "REACTOME:R-SPO-1483226" ]

10

[]

0

[]

0

[ "IPR000462" ]

[]

1

0

1

[ "Bacteria", "Eukaryota" ]

[ 3, 2843 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 1, 1, 4, 4, 1, 3, 3, 1, 1, 8 ]

12

true

Family

CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote

CDP_diag_ino_3_P_euk

8

IPR014388

14,388

3-oxoacid CoA-transferase

3-oxoacid_CoA-transferase

Family

9,452

false

CoA-transferases catalyse the reversible transfer of of coenzyme A from CoA-thioesters to free acids, and can be divided into three families [ ]. Family I includes transferases for 3-oxoacids ( , ), short-chain fatty acids ( , ) and glutaconate ( ). Most of the family I enzymes use acetyl-CoA or succinyl-CoA as CoA don...

[ "GO:0008410", "GO:0046952" ]

[ "CoA-transferase activity", "ketone body catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF000858" ]

[ "SCOT-t" ]

[ 9452 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.8.3.5", "R-CEL-77108", "R-CEL-9837999", "R-DDI-77108", "R-DDI-9837999", "R-DME-77108", "R-DME-9837999", "R-HSA-77108", "R-HSA-9837999", "R-MMU-77108", "R-MMU-9837999", "R-RNO-77108", "R-RNO-9837999", "R-SSC-77108", "R-SSC-9837999" ]

[ "EC:2.8.3.5", "REACTOME:R-CEL-77108", "REACTOME:R-CEL-9837999", "REACTOME:R-DDI-77108", "REACTOME:R-DDI-9837999", "REACTOME:R-DME-77108", "REACTOME:R-DME-9837999", "REACTOME:R-HSA-77108", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-77108", "REACTOME:R-MMU-9837999", "REACTOME:R-RNO-77108", "REA...

15

[ "1m3e", "1o9l", "1ooy", "1ooz", "1ope", "2ahu", "2ahv", "2ahw", "2nrb", "2nrc", "3dlx", "3k6m", "3oxo", "4kgb", "6lp1", "8i3y", "8i40" ]

17

[ "PUB00019325", "PUB00028140" ]

[ "11749953", "10409616" ]

[ "A new family of CoA-transferases.", "Oxygen exchange between acetate and the catalytic glutamate residue in glutaconate CoA-transferase from Acidaminococcus fermentans. Implications for the mechanism of CoA-ester hydrolysis." ]

[ 2001, 1999 ]

2

[ "IPR004165" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 78, 4348, 5004, 22 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus" ]

[ 1, 2, 3, 1, 5, 7, 2, 10 ]

8

true

Family

3-oxoacid CoA-transferase

3-oxoacid_CoA-transferase

6

IPR014390

14,390

Acid phosphatase, Aspergillus type

Acid_Pase_Asper

Family

437

false

This entry represents an acid phosphatase, Aspergillus type. Acid phosphatase is an enzyme with wide specificity that catalyses the reaction: A phosphate monoester + H(2)O = an alcohol + phosphate It also catalyses transphosphorylations and is competitively inhibited by phosphomycin and inorganic orthophosphate. The Em...

[ "GO:0003993" ]

[ "acid phosphatase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF000900" ]

[ "Acid_Ptase_Asper" ]

[ 437 ]

1

[]

0

[]

0

[ "PUB00043439" ]

[ "18050093" ]

[ "Identification of nutrient-dependent changes in extracellular pH and acid phosphatase secretion in Aspergillus nidulans." ]

[ 2007 ]

1

[ "IPR039331" ]

[]

1

0

1

[ "Dikarya" ]

[ 437 ]

1

[]

0

true

Family

Acid phosphatase, Aspergillus type

Acid_Pase_Asper

1

IPR014392

14,392

Protein-tyrosine phosphatase, non-receptor type-14/21

PTP_non-rcpt_14/21

Family

2,017

false

Protein tyrosine (pTyr) phosphorylation is a common post-translational modification which can create novel recognition motifs for protein interactions and cellular localisation, affect protein stability, and regulate enzyme activity. Consequently, maintaining an appropriate level of protein tyrosine phosphorylation is ...

[ "GO:0004725", "GO:0006470" ]

[ "protein tyrosine phosphatase activity", "protein dephosphorylation" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF000934" ]

[ "Tyr-Ptase_nr14" ]

[ 2017 ]

1

[ "EC", "REACTOME" ]

[ "3.1.3.48", "R-HSA-9008059" ]

[ "EC:3.1.3.48", "REACTOME:R-HSA-9008059" ]

2

[]

0

[ "PUB00035793", "PUB00035794", "PUB00035795", "PUB00035796", "PUB00035797", "PUB00035798" ]

[ "9818190", "14625689", "12678841", "16672235", "8948575", "9646865" ]

[ "Protein tyrosine phosphatases: mechanisms of catalysis and regulation.", "Receptor and nonreceptor protein tyrosine phosphatases in the nervous system.", "An overview of the protein tyrosine phosphatase superfamily.", "The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase dom...

[ 1998, 2003, 2003, 2006, 1996, 1998 ]

6

[]

0

null

[ "Vertebrata" ]

[ 2017 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 5, 11, 9 ]

4

true

Family

Protein-tyrosine phosphatase, non-receptor type-14/21

PTP_non-rcpt_14/21

4

IPR014394

14,394

Coagulation factor XII/hepatocyte growth factor activator

Coagulation_fac_XII/HGFA

Family

175

false

This entry represents coagulation factor XII/hepatocyte growth factor activator (HGFA). Both proteins included in this entry show a homologous domain structure [ ]. The proteins contain a C-terminal serine peptidase domain that belongs to MEROPS peptidase family S1A (clan PA(S)) [ , ].

[ "GO:0004252", "GO:0006508", "GO:0005615" ]

[ "serine-type endopeptidase activity", "proteolysis", "extracellular space" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF001146" ]

[ "Factor_XII_HGFA" ]

[ 175 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.21.38", "R-HSA-140837", "R-HSA-6806942", "R-HSA-9657688", "R-HSA-9657689", "R-MMU-140837", "R-MMU-6806942", "R-RNO-140837" ]

[ "EC:3.4.21.38", "REACTOME:R-HSA-140837", "REACTOME:R-HSA-6806942", "REACTOME:R-HSA-9657688", "REACTOME:R-HSA-9657689", "REACTOME:R-MMU-140837", "REACTOME:R-MMU-6806942", "REACTOME:R-RNO-140837" ]

8

[]

0

[ "PUB00054066", "PUB00054067", "PUB00085933" ]

[ "20558624", "19850327", "20402766" ]

[ "Factor XII bridges coagulation and fibrinolysis again.", "Why do we want to know how factor XII levels are modulated?", "Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor." ]

[ 2010, 2010, 2010 ]

3

[ "IPR001314" ]

[]

1

0

1

[ "Eutheria" ]

[ 175 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 8, 5, 3 ]

3

true

Family

Coagulation factor XII/hepatocyte growth factor activator

Coagulation_fac_XII/HGFA

8

IPR014395

14,395

Penicillin/GL-7-ACA/AHL acylase

Pen/GL7ACA/AHL_acylase

Family

13,708

false

Penicillin amidase or penicillin acylase catalyses the hydrolysis of benzylpenicillin to phenylacetic acid and 6-aminopenicillanic acid (6-APA) a key intermediate in the the synthesis of penicillins [ ]. This entry also includes glutaryl-7-aminocephalosporanic-acid (GL-7-ACA) acylase, acyl-homoserine lactone (AHL) acyl...

[ "GO:0016811" ]

[ "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF001227" ]

[ "Pen_acylase" ]

[ 13708 ]

1

[ "EC" ]

[ "3.5.1" ]

[ "EC:3.5.1" ]

1

[ "1keh", "3s8r", "4e55", "4e56", "4e57", "4pel", "4pem", "7ea4", "7eby" ]

9

[ "PUB00000144" ]

[ "9292993" ]

[ "Molecular cloning and analysis of the gene encoding the thermostable penicillin G acylase from Alcaligenes faecalis." ]

[ 1997 ]

1

[ "IPR002692" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 280, 13165, 112, 151 ]

4

[]

0

true

Family

Penicillin/GL-7-ACA/AHL acylase

Pen/GL7ACA/AHL_acylase

3

IPR014397

14,397

L-2-aminoadipate reductase

Lys2

Family

1,727

false

This entry represents a group of L-2-aminoadipate reductase from fungi, including Lys2 from budding yeasts. Lys2 is a alpha aminoadipate reductase that catalyses the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, the fifth step in lysine biosynthesis [ ].

[ "GO:0004043", "GO:0009085" ]

[ "L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity", "L-lysine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "TIGR03443" ]

[ "alpha_am_amid" ]

[ 1727 ]

1

[ "EC", "EC" ]

[ "1.2.1.31", "1.2.1.95" ]

[ "EC:1.2.1.31", "EC:1.2.1.95" ]

2

[]

0

[ "PUB00073591" ]

[ "4401608" ]

[ "Lysine biosynthesis in Saccharomyces. Conversion of -aminoadipate into -aminoadipic -semialdehyde." ]

[ 1971 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1727 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

L-2-aminoadipate reductase

Lys2

8

IPR014399

14,399

Cyclin CLN

Cyclin_CLN

Family

120

false

This entry represents a G1-class of cyclins which has so far only been identified in fungi [ , ]. These proteins are important for the control of the cell cycle at the G1/S transition and interact with the cdc2 protein kinase. Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division...

[ "GO:0000079", "GO:2000045" ]

[ "regulation of cyclin-dependent protein serine/threonine kinase activity", "regulation of G1/S transition of mitotic cell cycle" ]

[ "biological_process", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF001770" ]

[ "Cyclin_CLN" ]

[ 120 ]

1

[]

0

[]

0

[ "PUB00014101", "PUB00014103", "PUB00074994", "PUB00074995" ]

[ "11056549", "12910258", "9552356", "25619768" ]

[ "Cyclin' on the viral path to destruction.", "Cell cycle regulation and neural differentiation.", "The CLN gene family: central regulators of cell cycle Start in budding yeast.", "A docking interface in the cyclin Cln2 promotes multi-site phosphorylation of substrates and timely cell-cycle entry." ]

[ 2000, 2003, 1995, 2015 ]

4

[ "IPR039361" ]

[]

1

0

1

[ "Ascomycota" ]

[ 120 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1 ]

2

true

Family

Cyclin CLN

Cyclin_CLN

9

IPR014401

14,401

Small ribosomal subunit protein eS6-like

Ribosomal_eS6-like

Family

5,253

false

This entry represents the small ribosomal subunit protein eS6 found in eukaryotes, which was previously known as S6 [ ]. Ribosomal protein S6 is the major substrate of protein kinases in eukaryotic ribosomes [ ] and may play an important role in controlling cell growth and proliferation through the selective translatio...

[ "GO:0003735", "GO:0006412", "GO:0005840" ]

[ "structural constituent of ribosome", "translation", "ribosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF002129" ]

[ "Ribosom_S6_euk" ]

[ 5253 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-166208", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72649", "R-BTA-72689", "R-BTA-72695", "R-BTA-72702", "R-BTA-72706", "R-BTA-9629569", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-166208", "R-CEL-1799339", "R-CEL-6791226", "R-CEL-72649", "R-CEL-7268...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-166208", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72649", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72695", "REACTOME:R-BTA-72702", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-9629569", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-97595...

115

[ "3j16", "3j6x", "3j6y", "3j77", "3j78", "3j7p", "3j7r", "3j80", "3j81", "3jag", "3jah", "3jai", "3jaj", "3jam", "3jan", "3jap", "3jbn", "3jbo", "3jbp", "4d5l", "4d61", "4kzx", "4kzy", "4kzz", "4u3m", "4u3n", "4u3u", "4u4n", "4u4o", "4u4q", "4u4r", "4u4u"...

571

[ "PUB00002823", "PUB00007068", "PUB00007069", "PUB00007070", "PUB00080279" ]

[ "8440735", "11297922", "11290319", "11114498", "24524803" ]

[ "Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum.", "Atomic structures at last: the ribosome in 2000.", "The ribosome in focus.", "The end of the beginning: structural studies of ribosomal proteins.", "A new system for naming ribosomal p...

[ 1993, 2001, 2001, 2000, 2014 ]

5

[ "IPR001377" ]

[]

1

0

1

[ "Eukaryota", "Halopseudomonas pelagia" ]

[ 5252, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 4, 4, 4, 2, 4, 7, 2, 2, 12 ]

12

true

Family

Small ribosomal subunit protein eS6-like

Ribosomal_eS6-like

7

IPR014402

14,402

Transcription factor SKN7

SKN7

Family

1,277

false

This entry represents transcription factor, Skn7 type, including Skn7 from budding yeast and Prr1 from fission yeast [ , , ]. Transcription factor Skn7 is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment [ ...

[ "GO:0000156", "GO:0003700", "GO:0000160", "GO:0006355" ]

[ "phosphorelay response regulator activity", "DNA-binding transcription factor activity", "phosphorelay signal transduction system", "regulation of DNA-templated transcription" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "PIRSF" ]

[ "PIRSF002595" ]

[ "RR_SKN7" ]

[ 1277 ]

1

[]

0

[]

0

[ "PUB00010651", "PUB00011096", "PUB00027845", "PUB00027946", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807", "PUB00066493", "PUB00066540" ]

[ "12372152", "10966457", "7957083", "10888672", "16176121", "18076326", "11934609", "11489844", "14665464", "10348908" ]

[ "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Yeast Skn7p functions in a eukaryotic two-component regulatory pathway.", "The Skn7 response regulator of Saccharomyces cerevisiae interacts with Hsf1 in vivo and is required for the inducti...

[ 2002, 2000, 1994, 2000, 2005, 2007, 2002, 2001, 2003, 1999 ]

10

[]

0

null

[ "Eukaryota" ]

[ 1277 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Transcription factor SKN7

SKN7

5

IPR014404

14,404

A-agglutinin-binding subunit Aga2

Aga2

Family

53

false

Aga2 is an adhesion subunit of a-agglutinin of a-cells. Saccharomyces cerevisiae a and alpha cells express the complementary cell surface glycoproteins a-agglutinin and alpha-agglutinin, respectively, which interact with one another to promote cellular aggregation during fungal mating [ ]. Aga2 contains the adhesive do...

[ "GO:0050839", "GO:0000752", "GO:0009277" ]

[ "cell adhesion molecule binding", "agglutination involved in conjugation with cellular fusion", "fungal-type cell wall" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "PIRSF" ]

[ "PF17366", "PIRSF002695" ]

[ "AGA2", "A-agglutinin" ]

[ 53, 19 ]

2

[]

0

[]

0

[ "PUB00074601", "PUB00074602" ]

[ "11292808", "1756718" ]

[ "Interaction of alpha-agglutinin and a-agglutinin, Saccharomyces cerevisiae sexual cell adhesion molecules.", "Saccharomyces cerevisiae a- and alpha-agglutinin: characterization of their molecular interaction." ]

[ 2001, 1991 ]

2

[]

0

null

[ "Saccharomycetaceae" ]

[ 53 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

A-agglutinin-binding subunit Aga2

Aga2

4

IPR014407

14,407

5-methylcytosine restriction system component, bacterial

McrC_bac

Family

904

false

This group represents a McrBC 5-methylcytosine restriction system component. It modifies the specificity of mcrB restriction by expanding the range of modified sequences that are restricted [ , ].

[ "GO:0009307" ]

[ "DNA restriction-modification system" ]

[ "biological_process" ]

1

[ "NCBIFAM", "PIRSF" ]

[ "NF007277", "PIRSF003109" ]

[ "PRK09736.1", "McrC" ]

[ 601, 882 ]

2

[]

0

[ "6hz4", "6hz5", "6hz6", "6hz7", "6hz8", "6hz9", "6ut6", "7vsr" ]

8

[ "PUB00044348", "PUB00044349" ]

[ "2203735", "2050643" ]

[ "Genetic and sequence organization of the mcrBC locus of Escherichia coli K-12.", "Overproduction and purification of McrC protein from Escherichia coli K-12." ]

[ 1990, 1991 ]

2

[ "IPR019292" ]

[]

1

0

1

[ "Bacteria", "Methanobacteriota", "Siphoviridae sp. cte421", "ecological metagenomes" ]

[ 891, 9, 1, 3 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

5-methylcytosine restriction system component, bacterial

McrC_bac

3

IPR014408

14,408

Cyclic di-GMP phosphodiesterase CdgJ-like

CdgJ/PdeH

Family

4,979

false

This entry represents cyclic di-GMP phosphodiesterase CdgJ, PdeH, and related proteins. Members of this group contain an EAL domain and a modified HD-GYP domain (HDOD). The EAL domain functions as a diguanylate phosphodiesterase, catalysing the hydrolysis of cyclic diguanylate (c-di-GMP), a global second messenger in b...

[]

0

[ "PIRSF" ]

[ "PIRSF003180" ]

[ "DiGMPpdiest_YuxH" ]

[ 4979 ]

1

[]

0

[]

0

[ "PUB00005837", "PUB00007150", "PUB00011195", "PUB00011196", "PUB00015649", "PUB00017392", "PUB00018350", "PUB00027730" ]

[ "9868367", "11557134", "11123673", "10943560", "9721278", "15306016", "9537363", "1943994" ]

[ "The HD domain defines a new superfamily of metal-dependent phosphohydrolases.", "Novel domains of the prokaryotic two-component signal transduction systems.", "A two-component system involving an HD-GYP domain protein links cell-cell signalling to pathogenicity gene expression in Xanthomonas campestris.", "A...

[ 1998, 2001, 2000, 1999, 1998, 2004, 1998, 1991 ]

8

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 4919, 60 ]

2

[]

0

true

Family

Cyclic di-GMP phosphodiesterase CdgJ-like

CdgJ/PdeH

9

IPR014409

14,409

Signal transduction histidine kinase, hybrid-type, aerobic respiration control ArcB

Sig_transdc_His_kin_hyb_ArcB

Family

2,234

false

Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ ]. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk [ ]. These pathways have been adapt...

[ "GO:0000155", "GO:0004673", "GO:0000160", "GO:0016020" ]

[ "phosphorelay sensor kinase activity", "protein histidine kinase activity", "phosphorelay signal transduction system", "membrane" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "NCBIFAM", "PIRSF" ]

[ "NF008302", "PIRSF003182" ]

[ "PRK11091.1", "ArcB" ]

[ 2012, 2225 ]

2

[ "EC" ]

[ "2.7.13.3" ]

[ "EC:2.7.13.3" ]

1

[]

0

[ "PUB00000966", "PUB00007866", "PUB00010651", "PUB00011096", "PUB00013246", "PUB00013247", "PUB00013562", "PUB00013563", "PUB00020801", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807" ]

[ "9989504", "11406410", "12372152", "10966457", "8868347", "10426948", "8029829", "1482126", "11145881", "16176121", "18076326", "11934609", "11489844" ]

[ "Structure of CheA, a signal-transducing histidine kinase.", "Histidine kinases and response regulator proteins in two-component signaling systems.", "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Protein aspartate phosphatases control...

[ 1999, 2001, 2002, 2000, 1996, 1999, 1994, 1992, 2000, 2005, 2007, 2002, 2001 ]

13

[]

0

null

[ "Bacteria", "Nematoda", "marine sediment metagenome" ]

[ 2231, 2, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Signal transduction histidine kinase, hybrid-type, aerobic respiration control ArcB

Sig_transdc_His_kin_hyb_ArcB

6

IPR014410

14,410

Adenovirus early E1A protein

Aden_E1A

Family

664

false

This group represents adenoviral early E1A proteins. The E1A protein is responsible for the transcriptional activation of the early genes with in the viral genome at the start of the infection process as well as some cellular genes [ ]. E1A disrupts the function of host retinoblastoma protein RB1/pRb, which is a key re...

[ "GO:0006355", "GO:0044003" ]

[ "regulation of DNA-templated transcription", "symbiont-mediated perturbation of host process" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM", "PIRSF" ]

[ "PF02703", "PIRSF003669" ]

[ "Adeno_E1A", "Aden_E1A" ]

[ 664, 541 ]

2

[]

0

[ "2kje" ]

1

[ "PUB00007569", "PUB00073486", "PUB00073488" ]

[ "1835093", "1316611", "22718244" ]

[ "Conversion of the E1A Cys4 zinc finger to a nonfunctional His2,Cys2 zinc finger by a single point mutation.", "Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.", ...

[ 1991, 1992, 2013 ]

3

[]

0

null

[ "Adenoviridae" ]

[ 664 ]

1

[]

0

true

Family

Adenovirus early E1A protein

Aden_E1A

6

IPR014412

14,412

Genome polyprotein, Flavivirus

Gen_Poly_FLV

Family

10,350

false

This group represents a genome polyprotein from Flavivirus. The polyprotein is cleaved by peptidases (including the NS3 protein, a serine endopeptidase [ ]) into 14 chains, including the RNA-directed RNA polymerase NS5 or non-structural protein 5, with three activities: mRNA (guanine-N(7)-)-methyltransferase ( ), mRNA ...

[ "GO:0003968", "GO:0004252", "GO:0004482", "GO:0004483", "GO:0016817", "GO:0017111" ]

[ "RNA-directed RNA polymerase activity", "serine-type endopeptidase activity", "mRNA 5'-cap (guanine-N7-)-methyltransferase activity", "methyltransferase cap1 activity", "hydrolase activity, acting on acid anhydrides", "ribonucleoside triphosphate phosphatase activity" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function", "molecular_function", "molecular_function" ]

6

[ "PIRSF" ]

[ "PIRSF003817" ]

[ "Gen_Poly_FLV" ]

[ 10350 ]

1

[ "EC", "EC", "EC", "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.1.1.56", "2.1.1.57", "2.7.7.48", "3.4.21.91", "3.6.1.15", "3.6.4.13", "PWY-6545", "PWY-7184", "PWY-7185", "PWY-7198", "PWY-7210", "PWY-7375", "PWY-7379" ]

[ "EC:2.1.1.56", "EC:2.1.1.57", "EC:2.7.7.48", "EC:3.4.21.91", "EC:3.6.1.15", "EC:3.6.4.13", "METACYC:PWY-6545", "METACYC:PWY-7184", "METACYC:PWY-7185", "METACYC:PWY-7198", "METACYC:PWY-7210", "METACYC:PWY-7375", "METACYC:PWY-7379" ]

13

[ "8cxg", "8cxh", "8cxi" ]

3

[ "PUB00088375", "PUB00095857" ]

[ "17052977", "28345656" ]

[ "Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies.", "Structure and function of the Zika virus full-length NS5 protein." ]

[ 2006, 2017 ]

2

[]

0

null

[ "Flaviviridae" ]

[ 10350 ]

1

[]

0

true

Family

Genome polyprotein, Flavivirus

Gen_Poly_FLV

5

IPR014413

14,413

M polyprotein precursor, Orthobunyavirus type

M_poly_OrthobunV

Family

374

false

This group represents a M polyprotein precursor, Orthobunyavirus type.

[]

0

[ "PIRSF" ]

[ "PIRSF003944" ]

[ "M_poly_OrthobunV" ]

[ 374 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Orthobunyavirus" ]

[ 374 ]

1

[]

0

true

Family

M polyprotein precursor, Orthobunyavirus type

M_poly_OrthobunV

5

IPR014414

14,414

Envelope glycoprotein precursor/M polyprotein precursor, Tospovirus type

M_poly_TospoV

Family

318

false

This group represents an envelope glycoprotein precursor/M polyprotein precursor, Tospovirus type.

[]

0

[ "PIRSF" ]

[ "PIRSF003960" ]

[ "M_poly_TospoV" ]

[ 318 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Elliovirales" ]

[ 318 ]

1

[]

0

true

Family

Envelope glycoprotein precursor/M polyprotein precursor, Tospovirus type

M_poly_TospoV

9

IPR014416

14,416

DNA-directed DNA polymerase, family B, phi29-like virus

DNA-dir_DNA_polB_phi29_vir

Family

18

false

This group represents a family B type DNA-directed DNA polymerase found in the phi29-like viruses. They are polymerases responsible for protein-primed viral DNA replication by strand displacement with high processivity and fidelity [ , , ].

[ "GO:0001882", "GO:0003887", "GO:0039693" ]

[ "nucleoside binding", "DNA-directed DNA polymerase activity", "viral DNA genome replication" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF004178" ]

[ "Dpol_Bac_phage" ]

[ 18 ]

1

[ "EC", "EC" ]

[ "2.7.7.7", "3.1.11.-" ]

[ "EC:2.7.7.7", "EC:3.1.11.-" ]

2

[ "1xhx", "1xhz", "1xi1", "2ex3", "2py5", "2pyj", "2pyl", "2pzs" ]

8

[ "PUB00092793", "PUB00092794", "PUB00092795" ]

[ "8594354", "3863101", "2498321" ]

[ "Mutational analysis of bacteriophage phi 29 DNA polymerase.", "Replication of phage phi 29 DNA with purified terminal protein and DNA polymerase: synthesis of full-length phi 29 DNA.", "Highly efficient DNA synthesis by the phage phi 29 DNA polymerase. Symmetrical mode of DNA replication." ]

[ 1995, 1985, 1989 ]

3

[ "IPR006172" ]

[]

1

0

1

[ "Caudoviricetes" ]

[ 18 ]

1

[]

0

true

Family

DNA-directed DNA polymerase, family B, phi29-like virus

DNA-dir_DNA_polB_phi29_vir

3

IPR014418

14,418

Putative type 4B encapsulin shell protein

ENCP4

Family

74

false

Proteins in this entry may be the encapsulin shell protein in a type 4 A-domain encapsulin nanocompartment system. Its cargo may be upstream glyceraldehyde-3-phosphate dehydrogenase [ ]. It has been shown that bacterial/archaeal encapsulin-like systems and HK97-type viruses share a common ancestor and it is likely that...

[]

0

[ "NCBIFAM", "PIRSF" ]

[ "NF041191", "PIRSF004604" ]

[ "encap_f4b", "UCP004604" ]

[ 39, 73 ]

2

[]

0

[ "2pk8" ]

1

[ "PUB00100782", "PUB00106206" ]

[ "34362927", "35146412" ]

[ "Large-scale computational discovery and analysis of virus-derived microbial nanocompartments.", "Recent advances in the structural biology of encapsulin bacterial nanocompartments." ]

[ 2021, 2022 ]

2

[]

0

null

[ "Thermococcaceae" ]

[ 74 ]

1

[]

0

true

Family

Putative type 4B encapsulin shell protein

ENCP4

9

IPR014419

14,419

Heme utilization protein HutZ

HutZ

Family

1,664

false

Members of this family are heme utilization proteins, typically designated HutZ. They are members of the PPOX family ( ) and, except for the lack of an N-terminal extension, are closely related to one form of heme oxidase [ ]. Members typically are found in a three-gene operon with radical SAM enzyme HutW and a protein...

[]

0

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF004633", "TIGR04110" ]

[ "UCP_PLP_oxd", "heme_HutZ" ]

[ 1664, 523 ]

2

[ "GP" ]

[ "GenProp0961" ]

[ "GP:GenProp0961" ]

1

[ "1vl7", "3tgv", "6vna" ]

3

[ "PUB00060407", "PUB00060439", "PUB00092774", "PUB00092775", "PUB00092776" ]

[ "21030596", "15205415", "22627893", "28481076", "28607990" ]

[ "Crystal structure of HugZ, a novel heme oxygenase from Helicobacter pylori.", "HutZ is required for efficient heme utilization in Vibrio cholerae.", "A heme degradation enzyme, HutZ, from Vibrio cholerae.", "Heme Proximal Hydrogen Bonding between His170 and Asp132 Plays an Essential Role in the Heme Degradat...

[ 2011, 2004, 2012, 2017, 2017 ]

5

[]

0

null

[ "Bacteria", "Methanosarcinaceae", "ecological metagenomes" ]

[ 1638, 8, 18 ]

3

[]

0

true

Family

Heme utilization protein HutZ

HutZ

9

IPR014422

14,422

Cobalamin (vitamin B12) biosynthesis, bifunctional CbiH/CbiC

Cbl_synth_bifunc_CbiH/CbiC

Family

169

false

This entry represents a bifunctional enzyme of the cobalamin biosynthesis pathway. They contain both CbiH precorrin-3B C(17)-methyltransferase ( , ) and CbiC precorrin-8X methylmutase ( , ). CbiH catalyses the methylation of precorrin-3B at C-17 to produce precorrin-4. CbiC catalyses catalyses a methyl rearrangement in...

[ "GO:0009236" ]

[ "cobalamin biosynthetic process" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF004874" ]

[ "Prcrn_mtase_isom" ]

[ 169 ]

1

[]

0

[]

0

[ "PUB00009744", "PUB00014669", "PUB00014672", "PUB00015657", "PUB00035308", "PUB00035309", "PUB00035310", "PUB00070131" ]

[ "11215515", "11470433", "11153269", "12869542", "17163662", "16042605", "12055304", "23922391" ]

[ "Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum.", "Crystal structure of precorrin-8x methyl mutase.", "Multiple biosynthetic pathways for vitamin B12: variations on a central theme.", "Comparative genomics of the vitamin B12 metabolism and regulation in prokaryotes.", "B12 trafficking in ma...

[ 2000, 2001, 2001, 2003, 2006, 2005, 2002, 2013 ]

8

[]

0

null

[ "Archaeoglobus fulgidus", "Bacteroidota/Chlorobiota group", "bioreactor metagenome" ]

[ 5, 163, 1 ]

3

[]

0

true

Family

Cobalamin (vitamin B12) biosynthesis, bifunctional CbiH/CbiC

Cbl_synth_bifunc_CbiH/CbiC

3

IPR014426

14,426

Uncharacterised protein family UPF0282, hydrolase, metallo-beta-lactamase

UPF0282_hydrls

Family

391

false

This group represents a predicted hydrolase, metallo-beta-lactamase superfamily.

[]

0

[ "HAMAP", "PIRSF" ]

[ "MF_01406", "PIRSF004944" ]

[ "UPF0282", "UCP004944_hydrls" ]

[ 327, 372 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "groundwater metagenome" ]

[ 325, 65, 1 ]

3

[]

0

true

Family

Uncharacterised protein family UPF0282, hydrolase, metallo-beta-lactamase

UPF0282_hydrls

4

IPR014428

14,428

Crossover junction endodeoxyribonuclease Hjc, archaeal

Hjc_arc

Family

725

false

This group contains Holliday junction resolvases (HJRs) of the archaeal type, Hjc and Hje proteins [ ]. The Holliday junction is an essential intermediate of homologous recombination. Holliday junctions are four-stranded DNA complexes that are formed during recombination and related DNA repair events. In the presence o...

[]

0

[ "HAMAP", "NCBIFAM", "PIRSF", "PANTHER", "CDD" ]

[ "MF_01490", "NF040854", "PIRSF004985", "PTHR39651", "cd00523" ]

[ "HJ_Resolv_Hjc", "Hol_resolv_Hjc", "Hlld_jn_rslvs_ar", "", "Holliday_junction_resolvase" ]

[ 563, 664, 444, 725, 534 ]

5

[ "EC" ]

[ "3.1.21.10" ]

[ "EC:3.1.21.10" ]

1

[ "1gef", "1hh1", "1ipi", "1ob8", "1ob9", "2eo0", "2wcw", "2wcz", "2wiw", "2wiz", "2wj0", "4tkd", "4tkk" ]

13

[ "PUB00007198", "PUB00007199", "PUB00025665", "PUB00027724", "PUB00080498" ]

[ "10430863", "12126623", "11331763", "15479781", "10940317" ]

[ "A Holliday junction resolvase from Pyrococcus furiosus: functional similarity to Escherichia coli RuvC provides evidence for conserved mechanism of homologous recombination in Bacteria, Eukarya, and Archaea.", "The inherent properties of DNA four-way junctions: comparing the crystal structures of holliday juncti...

[ 1999, 2002, 2001, 2004, 2000 ]

5

[ "IPR002732" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Viruses", "ecological metagenomes" ]

[ 699, 3, 18, 5 ]

4

[]

0

true

Family

Crossover junction endodeoxyribonuclease Hjc, archaeal

Hjc_arc

2

IPR014430

14,430

Sterol desaturase Scs7

Scs7

Family

6,938

false

This entry represents a family of fatty acid hydroxylases, including Scs7 from budding yeasts and FA2H from animals and plants. They contain an N-terminal Cytochrome b5-like heme/steroid binding domain. Scs7 is a sphingolipid alpha-hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long cha...

[ "GO:0080132", "GO:0006629", "GO:0016020" ]

[ "fatty acid 2-hydroxylase activity", "lipid metabolic process", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF", "PANTHER" ]

[ "PIRSF005149", "PTHR12863" ]

[ "IPC-B_HD", "" ]

[ 2802, 6938 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.14.18.-", "PWY-6014", "PWY-6409", "PWY-6710", "PWY-7154", "PWY-8191", "R-HSA-1660661", "R-MMU-1660661", "R-RNO-1660661", "R-SCE-1660661", "R-SPO-1660661" ]

[ "EC:1.14.18.-", "METACYC:PWY-6014", "METACYC:PWY-6409", "METACYC:PWY-6710", "METACYC:PWY-7154", "METACYC:PWY-8191", "REACTOME:R-HSA-1660661", "REACTOME:R-MMU-1660661", "REACTOME:R-RNO-1660661", "REACTOME:R-SCE-1660661", "REACTOME:R-SPO-1660661" ]

11

[ "4zr0", "4zr1" ]

2

[ "PUB00019532", "PUB00074249", "PUB00074251" ]

[ "9353282", "15337768", "15658937" ]

[ "Fah1p, a Saccharomyces cerevisiae cytochrome b5 fusion protein, and its Arabidopsis thaliana homolog that lacks the cytochrome b5 domain both function in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids.", "The human FA2H gene encodes a fatty acid 2-hydroxylase.", "A mammalian fat...

[ 1997, 2004, 2005 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Megamimivirinae", "metagenomes" ]

[ 2140, 4767, 7, 24 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 1, 1, 4, 1, 1, 4, 3, 1, 1, 7 ]

12

true

Family

Sterol desaturase Scs7

Scs7

1

IPR014431

14,431

Tellurite resistance methyltransferase, TehB type-2

Tellurite-R_TehB-2

Family

1,058

false

Tellurite resistance protein TehB is encoded by tellurite-reducing operon tehAB [ ]. Members of this entry are two-domain proteins with a C-terminal S-adenosyl-L-methionine (SAM)-dependent methyltransferase domain and an N-terminal domain of unknown function. In Escherichia coli, Salmonella and some other organisms, th...

[]

0

[ "PIRSF" ]

[ "PIRSF005215" ]

[ "TehB" ]

[ 1058 ]

1

[]

0

[ "3m70" ]

1

[ "PUB00014885", "PUB00027707", "PUB00027741" ]

[ "11053398", "10339832", "11032735" ]

[ "Escherichia coli TehB requires S-adenosylmethionine as a cofactor to mediate tellurite resistance.", "Characterization of gram-positive tellurite resistance encoded by the Streptococcus pneumoniae tehB gene.", "The role of cysteine residues in tellurite resistance mediated by the TehAB determinant." ]

[ 2000, 1999, 2000 ]

3

[ "IPR004537" ]

[]

1

0

1

[ "Bacteria", "Gregarina niphandrodes" ]

[ 1057, 1 ]

2

[]

0

true

Family

Tellurite resistance methyltransferase, TehB type-2

Tellurite-R_TehB-2

3

IPR014433

14,433

Carbon monoxide dehydrogenase accessory protein CooC

CooC

Family

2,041

false

Carbon monoxide dehydrogenase (CO dehydrogenase), as well as other nickel metalloenzymes, it is synthesized as a precursor that is devoid of the metalloenzyme active site. These precursors undergo a complex post-translational maturation process that requires a number of accessory proteins [ , , ]. Members of this entry...

[]

0

[ "PIRSF" ]

[ "PIRSF005647" ]

[ "CooC" ]

[ 2041 ]

1

[]

0

[ "3kje", "3kjg", "3kjh", "3kji" ]

4

[ "PUB00013569", "PUB00014601", "PUB00015238", "PUB00017398", "PUB00027728", "PUB00027766", "PUB00027788", "PUB00158991" ]

[ "12196162", "10226043", "10966576", "8955306", "12538050", "11507093", "9079911", "27382049" ]

[ "Metal insertion into NiFe-hydrogenases.", "Structure/function relationships in nickel metallobiochemistry.", "The synthetase domains of cobalamin biosynthesis amidotransferases cobB and cobQ belong to a new family of ATP-dependent amidoligases, related to dethiobiotin synthetase.", "Analysis of the CO dehydr...

[ 2002, 1999, 2000, 1996, 2003, 2001, 1997, 2016 ]

8

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 647, 1306, 88 ]

3

[]

0

true

Family

Carbon monoxide dehydrogenase accessory protein CooC

CooC

7

IPR014434

14,434

Monothiol glutaredoxin

Monothiol_GRX

Family

10,036

false

Glutaredoxins [ , , ], also known as thioltransferases (disulphide reductases), are small proteins of approximately one hundred amino-acid residues which utilise glutathione and NADPH as cofactors. Oxidized glutathione is regenerated by glutathione reductase. Together these components compose the glutathione system [ ]...

[ "GO:0015036" ]

[ "disulfide oxidoreductase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF005894" ]

[ "Monothiol_GRX" ]

[ 10036 ]

1

[]

0

[ "1wik", "1yka", "2lku", "2ltk", "2mma", "2mmz", "2wci", "2wul", "2yan", "3gx8", "3ipz", "3zyw", "5y4u" ]

13

[ "PUB00000560", "PUB00001738", "PUB00002504", "PUB00005575", "PUB00014033", "PUB00015562", "PUB00016736", "PUB00016830", "PUB00023503", "PUB00030238", "PUB00080925", "PUB00080927" ]

[ "3286320", "3152490", "2668278", "1994586", "14713336", "14962389", "11084362", "11950925", "9860827", "10493864", "15706083", "15814611" ]

[ "Thioredoxin and glutaredoxin: small multi-functional redox proteins with active-site disulphide bonds.", "Thioredoxin and related proteins in procaryotes.", "Thioredoxin and glutaredoxin systems.", "Vaccinia virus encodes a protein with similarity to glutaredoxins.", "Glutaredoxins: glutathione-dependent r...

[ 1988, 1988, 1989, 1991, 2004, 2004, 2000, 2002, 1998, 1999, 2005, 2005 ]

12

[ "IPR004480" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriati", "unclassified sequences" ]

[ 9313, 418, 153, 152 ]

4

[ "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica" ]

[ 1, 1 ]

2

true

Family

Monothiol glutaredoxin

Monothiol_GRX

9

IPR014435

14,435

N(4)-bis(aminopropyl)spermidine synthase

BpsA

Family

254

false

BpsA synthesizes N(4)-bis(aminopropyl)spermidine from spermidine via N(4)-aminopropylspermidine. It is involved in the biosynthesis of branched-chain polyamines, which support the growth of thermophiles under high-temperature conditions [ ].

[ "GO:0016765", "GO:0006596" ]

[ "transferase activity, transferring alkyl or aryl (other than methyl) groups", "polyamine biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "HAMAP", "PIRSF" ]

[ "MF_01947", "PIRSF005895" ]

[ "Aminopropyltransf_BpsA", "UCP005895_mtase" ]

[ 216, 212 ]

2

[ "EC" ]

[ "2.5.1.128" ]

[ "EC:2.5.1.128" ]

1

[ "2qm3", "5xnc", "5xnf", "5xnh", "6j26", "6j27", "6j28" ]

7

[ "PUB00074302" ]

[ "24610711" ]

[ "Identification of a novel aminopropyltransferase involved in the synthesis of branched-chain polyamines in hyperthermophiles." ]

[ 2014 ]

1

[]

0

null

[ "Bacteria", "Methanobacteriati" ]

[ 145, 109 ]

2

[]

0

true

Family

N(4)-bis(aminopropyl)spermidine synthase

BpsA

6

IPR014436

14,436

Extradiol aromatic ring-opening dioxygenase, DODA-type

Extradiol_dOase_DODA

Family

17,896

false

4,5-DOPA dioxygenase catalyses the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine (4,5-DOPA). The reaction results in the opening of the cyclic ring between carbons 4 and 5 and producing an unstable seco-DOPA that rearranges to betalamic acid. 4,5-DOPA dioxygenase is a key enzyme in th...

[ "GO:0008270", "GO:0051213" ]

[ "zinc ion binding", "dioxygenase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PIRSF", "CDD" ]

[ "PIRSF006157", "cd07363" ]

[ "Doxgns_DODA", "45_DOPA_Dioxygenase" ]

[ 15919, 17894 ]

2

[ "EC", "METACYC" ]

[ "1.13.11.29", "PWY-5394" ]

[ "EC:1.13.11.29", "METACYC:PWY-5394" ]

2

[ "2pw6", "8in2", "9j2l" ]

3

[ "PUB00027910", "PUB00080818", "PUB00099570" ]

[ "14730069", "23666480", "19366710" ]

[ "Characterization and functional identification of a novel plant 4,5-extradiol dioxygenase involved in betalain pigment biosynthesis in Portulaca grandiflora.", "Escherichia coli protein YgiD produces the structural unit of plant pigments betalains: characterization of a prokaryotic enzyme with DOPA-extradiol-dio...

[ 2004, 2014, 2009 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Sym plasmid", "unclassified sequences" ]

[ 91, 12362, 5283, 2, 158 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 4, 1, 1, 8, 1, 9 ]

6

true

Family

Extradiol aromatic ring-opening dioxygenase, DODA-type

Extradiol_dOase_DODA

5

IPR014438

14,438

Glucan biosynthesis protein MdoG/MdoD

Glucan_biosyn_MdoG/MdoD

Family

8,379

false

Membrane-derived oligosaccharides (MDO) are members of a family of glucans found in the periplasmic space of Gram-negative bacteria. MdoG has been shown to be necessary for the synthesis of MDO [ ], but its exact function is not known yet. MdoD, an MdoG paralog, is a twin-arginine-dependent periplasmic protein that con...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF006281", "PTHR30504" ]

[ "MdoG", "" ]

[ 7738, 8379 ]

2

[]

0

[ "1txk", "8iox", "8ip1", "8ip2", "8x18", "9e01", "9e08" ]

7

[ "PUB00027713", "PUB00027777", "PUB00027791" ]

[ "15175282", "7934824", "11325942" ]

[ "Identification of mdoD, an mdoG paralog which encodes a twin-arginine-dependent periplasmic protein that controls osmoregulated periplasmic glucan backbone structures.", "Homology between a genetic locus (mdoA) involved in the osmoregulated biosynthesis of periplasmic glucans in Escherichia coli and a genetic lo...

[ 2004, 1993, 2001 ]

3

[]

[ "IPR023704", "IPR023724" ]

0

2

0

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 8314, 13, 52 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Family

Glucan biosynthesis protein MdoG/MdoD

Glucan_biosyn_MdoG/MdoD

7

IPR014441

14,441

Uncharacterised conserved protein UCP006425, beta-propeller-type

UCP006425_b-propeller

Family

437

false

There is currently no experimental data characterising members of this group or their homologues. However, they contain a β-propeller domain distantly related to WD-40 repeats in their mid- to C-terminal part (SCOP superfamily WD40 as detected by SMART with marginal score). Members of this group are thought to be secre...

[]

0

[ "PIRSF" ]

[ "PIRSF006425" ]

[ "UCP006425_WD40" ]

[ 437 ]

1

[]

0

[]

0

[]

0

[ "IPR019198" ]

[]

1

0

1

[ "Anaeramoeba ignava", "Archaea", "Bacteria", "ecological metagenomes" ]

[ 1, 107, 327, 2 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP006425, beta-propeller-type

UCP006425_b-propeller

2

IPR014444

14,444

Damage-control phosphatase PH1575-like

PH1575-like

Family

1,238

false

This family represents metal-dependent phosphatases found in bacteria and archaea, with probable damage-control functions, including Damage-control phosphatase PH1575 from Pyrococcus horikoshii [ ]. It shows phosphatase activity against p-nitrophenyl phosphate (pNPP), but natural substrates have not been identified yet...

[]

0

[ "PIRSF" ]

[ "PIRSF006593" ]

[ "UCP006593" ]

[ 1238 ]

1

[]

0

[ "2ffj", "2g8l" ]

2

[ "PUB00088733" ]

[ "27322068" ]

[ "A family of metal-dependent phosphatases implicated in metabolite damage-control." ]

[ 2016 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 380, 805, 5, 48 ]

4

[]

0

true

Family

Damage-control phosphatase PH1575-like

PH1575-like

8

IPR014445

14,445

Glutamine-dependent NAD(+) synthetase

Gln-dep_NAD_synthase

Family

20,663

false

This group represents the glutamine-dependent NAD(+) synthetases with the GAT domain from archaea, bacteria to humans. NAD+ is involved electron transport and redox reactions and in DNA ligation and protein ADP-ribosylation. In yeast and most other organisms, NAD is generated through the de novo pathway and the salvage...

[ "GO:0003952", "GO:0005524", "GO:0009435" ]

[ "NAD+ synthase (glutamine-hydrolyzing) activity", "ATP binding", "NAD+ biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "PIRSF" ]

[ "MF_02090", "PIRSF006630" ]

[ "NadE_glutamine_dep", "NADS_GAT" ]

[ 19340, 20442 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.3.5.1", "PWY-5381", "PWY-5653", "PWY-7761", "PWY-8277", "PWY-8352", "R-BTA-196807", "R-DDI-196807", "R-DME-196807", "R-HSA-196807", "R-MMU-196807", "R-RNO-196807", "R-SCE-196807", "R-SPO-196807" ]

[ "EC:6.3.5.1", "METACYC:PWY-5381", "METACYC:PWY-5653", "METACYC:PWY-7761", "METACYC:PWY-8277", "METACYC:PWY-8352", "REACTOME:R-BTA-196807", "REACTOME:R-DDI-196807", "REACTOME:R-DME-196807", "REACTOME:R-HSA-196807", "REACTOME:R-MMU-196807", "REACTOME:R-RNO-196807", "REACTOME:R-SCE-196807", "...

14

[ "3dla", "3ilv", "3n05", "3sdb", "3seq", "3sez", "3syt", "3szg", "4f4h", "5kha", "6ofb", "6ofc" ]

12

[ "PUB00070122", "PUB00070123", "PUB00070124" ]

[ "12898714", "7890752", "12771147" ]

[ "Saccharomyces cerevisiae QNS1 codes for NAD(+) synthetase that is functionally conserved in mammals.", "The outB gene of Bacillus subtilis codes for NAD synthetase.", "Eukaryotic NAD+ synthetase Qns1 contains an essential, obligate intramolecular thiol glutamine amidotransferase domain related to nitrilase." ]

[ 2003, 1995, 2003 ]

3

[ "IPR003694" ]

[]

1

0

1

[ "Agrobacterium phage Atu_ph07", "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1, 64, 15415, 4769, 414 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 2, 1, 2, 1, 3, 1, 3, 6, 1, 1, 11 ]

12

true

Family

Glutamine-dependent NAD(+) synthetase

Gln-dep_NAD_synthase

2

IPR014447

14,447

Antitoxin VapB-like, probable

VapB-like_prob

Family

2,654

false

This protein family includes a group of uncharacterised short sequences from actinobacteria, including the probable Antitoxin VapB from Streptomyces cyaneogriseus ( ). Members of this family are predicted to adopt an α-β structure.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF23719", "PIRSF006909" ]

[ "VapB", "UCP006909" ]

[ 2654, 2478 ]

2

[]

0

[]

0

[ "PUB00155614" ]

[ "36243697" ]

[ "Comparative genome analysis of mycobacteria focusing on tRNA and non-coding RNA." ]

[ 2022 ]

1

[]

0

null

[ "Arthrobacter phage Sonali", "Bacteria", "metagenomes" ]

[ 1, 2640, 13 ]

3

[]

0

true

Family

Antitoxin VapB-like, probable

VapB-like_prob

3

IPR014448

14,448

Anti-adapter protein IraM

Anti-adapter_IraM

Family

642

false

The IraM protein was originally named enhancing lycopene biosynthesis protein 1 on the basis of its ability to restore lycopene production in mutants [ ]. It has subsequently been shown that this protein inhibits rpoS proteolysis by regulating rssB activity, thereby increasing the stability of the sigma stress factor r...

[ "GO:0005737" ]

[ "cytoplasm" ]

[ "cellular_component" ]

1

[ "HAMAP", "NCBIFAM", "PIRSF" ]

[ "MF_01199", "NF007393", "PIRSF007036" ]

[ "Anti_adapt_IraM", "PRK09919.1", "Elb1" ]

[ 522, 642, 420 ]

3

[]

0

[ "8twd" ]

1

[ "PUB00027909", "PUB00044149" ]

[ "9603997", "18383615" ]

[ "Identification of genes affecting lycopene formation in Escherichia coli transformed with carotenoid biosynthetic genes: candidates for early genes in isoprenoid biosynthesis.", "Multiple pathways for regulation of sigmaS (RpoS) stability in Escherichia coli via the action of multiple anti-adaptors." ]

[ 1998, 2008 ]

2

[]

0

null

[ "Enterobacterales", "Viruses" ]

[ 639, 3 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Anti-adapter protein IraM

Anti-adapter_IraM

3

IPR014450

14,450

Uncharacterised conserved protein UCP008210

UCP008210

Family

109

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09921", "PIRSF008210" ]

[ "DUF2153", "UCP008210" ]

[ 109, 71 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Thermoproteati" ]

[ 109 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP008210

UCP008210

9

IPR014451

14,451

Uncharacterised conserved protein UCP008455

UCP008455

Family

136

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF008455" ]

[ "UCP008455" ]

[ 136 ]

1

[]

0

[]

0

[]

0

[ "IPR015001" ]

[]

1

0

1

[ "Methanobacteriota" ]

[ 136 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP008455

UCP008455

6

IPR014453

14,453

Inhibitor of vertebrate lysozyme

Inhibitor_vertebrate_lysozyme

Family

1,154

false

C-type lysozyme enzymes, such as hen egg white lysozyme (HEWL), provide anti-bacterial activity by cleaving peptidoglycan in Gram-positive bacterial cell walls. In humans, C-type lysozyme is found in all secretions, including tears and saliva. Certain Gram-positive bacteria can produce proteins with anti-lysozyme activ...

[ "GO:0043086", "GO:0042597" ]

[ "negative regulation of catalytic activity", "periplasmic space" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF009103" ]

[ "Ivy" ]

[ 1154 ]

1

[]

0

[ "1gpq", "1uuz", "1xs0", "4ps6" ]

4

[ "PUB00027883", "PUB00027919", "PUB00042565" ]

[ "11278658", "15141308", "17405861" ]

[ "Escherichia coli ykfE ORFan gene encodes a potent inhibitor of C-type lysozyme.", "Periplasmic lysozyme inhibitor contributes to lysozyme resistance in Escherichia coli.", "Structure and evolution of the Ivy protein family, unexpected lysozyme inhibitors in Gram-negative bacteria." ]

[ 2001, 2004, 2007 ]

3

[]

0

null

[ "Panagrolaimus superbus", "Pseudomonadota", "bioreactor metagenome" ]

[ 1, 1152, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Inhibitor of vertebrate lysozyme

Inhibitor_vertebrate_lysozyme

9

IPR014455

14,455

DNA methylase, N-6 adenine-specific, MK1259 type

N6_adenine_Mtase_MK1259

Family

56

false

Proteins of this group contain the N6-adenine-specific DNA methylase signature ( ) in the C-terminal half of the sequence. This motif is characteristic of N6-adenine-specific DNA methylases [ , , ]and is thought to be involved in substrate binding or catalytic activity [ , ]. Members also contain one or two Zn-ribbon m...

[]

0

[ "PIRSF" ]

[ "PIRSF009427" ]

[ "UCP009427_DNAmts" ]

[ 56 ]

1

[]

0

[]

0

[ "PUB00001857", "PUB00003245", "PUB00027727", "PUB00027754", "PUB00027799" ]

[ "7607512", "2541254", "8341592", "3902803", "2510127" ]

[ "Sequence motifs characteristic for DNA [cytosine-N4] and DNA [adenine-N6] methyltransferases. Classification of all DNA methyltransferases.", "Evolution of type II DNA methyltransferases. A gene duplication model.", "The role of the preserved sequences of Dam methylase.", "Common evolutionary origin of the p...

[ 1995, 1989, 1993, 1985, 1989 ]

5

[]

0

null

[ "Archaea", "Bacteria" ]

[ 35, 21 ]

2

[]

0

true

Family

DNA methylase, N-6 adenine-specific, MK1259 type

N6_adenine_Mtase_MK1259

1

IPR014456

14,456

Uncharacterised conserved protein UCP010244, integral membrane protein

UCP010244_IM

Family

844

false

This group represents a predicted integral membrane protein.

[]

0

[ "PIRSF" ]

[ "PIRSF010244" ]

[ "UCP010244_imp" ]

[ 844 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphaproteobacteria", "Archaeoglobus fulgidus", "ecological metagenomes" ]

[ 836, 6, 2 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP010244, integral membrane protein

UCP010244_IM

8

IPR014457

14,457

Uncharacterised conserved protein UCP010260

UCP010260

Family

2,679

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members of this group encoded by Streptomyces coelicolor and Streptomyces avermitilis colocalize with glycogen metabolism cluster I proteins (such as glycogen phosphorylase). H...

[]

0

[ "PIRSF" ]

[ "PIRSF010260" ]

[ "UCP010260" ]

[ 2679 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2671, 3, 5 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP010260

UCP010260

1

IPR014458

14,458

Uncharacterised protein family, phage P2-GpU-fusion

Unchr_Phage_P2-GpU-fusion

Family

372

false

This entry consists of bacterial aproteins, restricted to Pseudomonas and Burkholderia species, of around 250 to 290 residues in length. The proteins all have a C-terminal bacteriophage P2 GpU domain, which is thought to be involved in tail assembly [ ]. These proteins are probable fusion proteins of unknown function.

[]

0

[ "PIRSF" ]

[ "PIRSF011237" ]

[ "UP2" ]

[ 372 ]

1

[]

0

[ "6u5b" ]

1

[ "PUB00012968" ]

[ "12426340" ]

[ "Programmed translational frameshift in the bacteriophage P2 FETUD tail gene operon." ]

[ 2002 ]

1

[ "IPR009734" ]

[]

1

0

1

[ "Pseudomonadota", "uncultured Caudovirales phage" ]

[ 371, 1 ]

2

[]

0

true

Family

Uncharacterised protein family, phage P2-GpU-fusion

Unchr_Phage_P2-GpU-fusion

4

IPR014459

14,459

Transcriptional activator VP30, Filoviridae type

VP30_FiloV

Family

262

false

VP30 is a nucleocapsid-associated Ebola virus-specific transcription factor [ , ]. It acts by stabilising nascent mRNA in Ebola virus replication. The C-terminal domain of VP30 folds into a dimeric helical assembly. VP30 assembles into hexamers in solution by an N-terminal oligomerization domain which activates the tra...

[ "GO:0003723", "GO:0008270" ]

[ "RNA binding", "zinc ion binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "PIRSF" ]

[ "PF11507", "PIRSF011356" ]

[ "Transcript_VP30", "VP30_FiloV" ]

[ 262, 192 ]

2

[]

0

[ "2i8b", "3v7o", "5dvw", "5t3t", "5t3w", "5vao", "5vap", "6e5x", "6lus", "6ydr", "7xiv", "9jqk" ]

12

[ "PUB00041637", "PUB00096658", "PUB00096659", "PUB00096660" ]

[ "17202263", "27279615", "18829754", "28593988" ]

[ "Crystal structure of the C-terminal domain of Ebola virus VP30 reveals a role in transcription and nucleocapsid association.", "RNA Binding of Ebola Virus VP30 Is Essential for Activating Viral Transcription.", "Role of Ebola virus VP30 in transcription reinitiation.", "Ebola virus VP30 and nucleoprotein int...

[ 2007, 2016, 2008, 2017 ]

4

[]

0

null

[ "Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)", "Filoviridae" ]

[ 1, 261 ]

2

[]

0

true

Family

Transcriptional activator VP30, Filoviridae type

VP30_FiloV

5

IPR014460

14,460

Signal transduction response regulator, predicted, VieB

Sig_transdc_resp-reg_VieB

Family

140

false

Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ ]. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk [ ]. These pathways have been adapt...

[]

0

[ "PIRSF" ]

[ "PIRSF011521" ]

[ "VieB" ]

[ 140 ]

1

[]

0

[]

0

[ "PUB00007866", "PUB00010651", "PUB00011096", "PUB00011157", "PUB00011190", "PUB00027755", "PUB00027760", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807" ]

[ "11406410", "12372152", "10966457", "10622255", "10500846", "9573178", "12107127", "16176121", "18076326", "11934609", "11489844" ]

[ "Histidine kinases and response regulator proteins in two-component signaling systems.", "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Structure of a transiently phosphorylated switch in bacterial signal transduction.", "The histidine...

[ 2001, 2002, 2000, 1999, 1999, 1998, 2002, 2005, 2007, 2002, 2001 ]

11

[]

0

null

[ "Gammaproteobacteria" ]

[ 140 ]

1

[]

0

true

Family

Signal transduction response regulator, predicted, VieB

Sig_transdc_resp-reg_VieB

8

IPR014462

14,462

Phage-associated protein Gp45

Phage_Mu_Gp45

Family

1,792

false

This entry includes Gp45 from bacteriophage Mu. Gp45 is a component of the baseplate that forms a central needlelike spike used to puncture the host cell membrane for tube insertion during virus entry. It serves as the distal plug of tail tube channel and might regulate the process of the phage DNA and protein ejection...

[]

0

[ "PIRSF" ]

[ "PIRSF012337" ]

[ "gp45" ]

[ 1792 ]

1

[]

0

[ "9ki1" ]

1

[ "PUB00065189", "PUB00077063" ]

[ "22922659", "20478417" ]

[ "Crystal structure of the C-terminal domain of Mu phage central spike and functions of bound calcium ion.", "The C-terminal domain is sufficient for host-binding activity of the Mu phage tail-spike protein." ]

[ 2013, 2010 ]

2

[ "IPR013046" ]

[]

1

0

1

[ "Bacteria", "Caudoviricetes", "Endopterygota", "metagenomes" ]

[ 1769, 15, 2, 6 ]

4

[]

0

true

Family

Phage-associated protein Gp45

Phage_Mu_Gp45

3

IPR014464

14,464

Conserved virulence factor B

CvfB_fam

Family

8,971

false

Conserved virulence factor B proteins contribute to the expression of virulence factors and to pathogenicity via both agr-dependent and agr-independent pathways [ ].

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF012524", "PTHR37296" ]

[ "YitL_S1", "" ]

[ 8486, 8971 ]

2

[]

0

[ "3go5" ]

1

[ "PUB00070985" ]

[ "17283102" ]

[ "Regulation of exoprotein gene expression by the Staphylococcus aureus cvfB gene." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 8829, 52, 90 ]

3

[]

0

true

Family

Conserved virulence factor B

CvfB_fam

1

IPR014468

14,468

Uncharacterised conserved protein UCP014979

UCP014979

Family

246

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF014979" ]

[ "UCP014979" ]

[ 246 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 246 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP014979

UCP014979

6

IPR014469

14,469

Protein of unknown function DUF2271

DUF2271

Family

3,389

false

This family of bacterial proteins is functionally uncharacterised. Members in this family contain the conserved [S/T]GA[S/T] motif and are ApbE substrates which suggests that they may be involved in extra cytosolic redox activities [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10029", "PIRSF014995" ]

[ "DUF2271", "UCP014995" ]

[ 3389, 1651 ]

2

[]

0

[]

0

[ "PUB00098250" ]

[ "34032212" ]

[ "Post-translational flavinylation is associated with diverse extracytosolic redox functionalities throughout bacterial life." ]

[ 2021 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 3360, 2, 27 ]

3

[]

0

true

Family

Protein of unknown function DUF2271

DUF2271

6

IPR014470

14,470

Uncharacterised conserved protein UCP01500

UCP01500

Family

1,242

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10028", "PIRSF015000" ]

[ "DUF2270", "UCP01500" ]

[ 1242, 945 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Halobacteria", "Opisthokonta", "Terrestrivirus sp.", "metagenomes" ]

[ 815, 411, 6, 1, 9 ]

5

[]

0

true

Family

Uncharacterised conserved protein UCP01500

UCP01500

2

IPR014472

14,472

Choline/ethanolamine phosphotransferase

CHOPT

Family

11,917

false

This group represents a choline/ethanolamine phosphotransferase [ , ].

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF015665", "PTHR10414" ]

[ "CHOPT", "" ]

[ 8492, 11917 ]

2

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "2.7.8", "2.7.8.2", "PWY-3561", "PWY-6804", "PWY-7618", "PWY-7782", "PWY-8051", "PWY-8053", "PWY-8055", "R-BTA-1483191", "R-BTA-1483213", "R-DDI-1483191", "R-DDI-1483213", "R-DRE-1483191", "R-GGA-1483191", "R-HSA-1483191", "R-HSA-1483213", "R-MMU-1483191", "R-MMU-1483213", "R-R...

[ "EC:2.7.8", "EC:2.7.8.2", "METACYC:PWY-3561", "METACYC:PWY-6804", "METACYC:PWY-7618", "METACYC:PWY-7782", "METACYC:PWY-8051", "METACYC:PWY-8053", "METACYC:PWY-8055", "REACTOME:R-BTA-1483191", "REACTOME:R-BTA-1483213", "REACTOME:R-DDI-1483191", "REACTOME:R-DDI-1483213", "REACTOME:R-DRE-1483...

27

[ "8ero", "8erp", "8gyw", "8gyx", "8ul9", "8urp", "8urt", "9uet" ]

8

[ "PUB00053874", "PUB00053875" ]

[ "10191259", "12216837" ]

[ "Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine.", "PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase ...

[ 1999, 2002 ]

2

[ "IPR000462" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriati", "Mimiviridae", "metagenomes" ]

[ 178, 11716, 6, 10, 7 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 3, 6, 13, 15, 13, 3, 8, 13, 2, 1, 28 ]

12

true

Family

Choline/ethanolamine phosphotransferase

CHOPT

6

IPR014476

14,476

AT-hook motif nuclear-localized protein 15-29

AHL15-29

Family

8,032

false

This entry includes AT-hook motif nuclear-localized proteins 15-29 (AHL15-29) from Arabidopsis [ ]. They have two conserved structural units, the AT-hook motif and the Plant and Prokaryote Conserved (PPC) domain, the latter also known as DUF296. Members of the AHL family regulate diverse aspects of growth and developme...

[ "GO:0003680" ]

[ "minor groove of adenine-thymine-rich DNA binding" ]

[ "molecular_function" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF016021", "PTHR31100" ]

[ "ESCAROLA", "" ]

[ 3756, 8032 ]

2

[]

0

[]

0

[ "PUB00074291", "PUB00089867" ]

[ "25311531", "20738724" ]

[ "Insights into the evolution and diversification of the AT-hook Motif Nuclear Localized gene family in land plants.", "Overexpression of AHL20 negatively regulates defenses in Arabidopsis." ]

[ 2014, 2010 ]

2

[]

0

null

[ "Viridiplantae" ]

[ 8032 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 48, 45, 50 ]

3

true

Family

AT-hook motif nuclear-localized protein 15-29

AHL15-29

9

IPR014478

14,478

Putative membrane protein, NMB1733 type

UCP016195

Family

25

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. However, they are predicted to be integral membrane proteins (with several transmembrane segments).

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27664", "PIRSF016195" ]

[ "UCP016195", "UCP016195" ]

[ 25, 19 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Neisseria" ]

[ 25 ]

1

[]

0

true

Family

Putative membrane protein, NMB1733 type

UCP016195

4

IPR014480

14,480

Mannan endo-1,6-alpha-mannosidase

Mannan-1_6-alpha_mannosidase

Family

7,179

false

Mannan endo-1,6-alpha-mannosidases such as DCW1 and DFG5 from Saccharomyces cerevisiae are GPI-anchored membrane proteins required for normal biosynthesis of the cell wall [ ].

[ "GO:0008496", "GO:0016052" ]

[ "mannan endo-1,6-alpha-mannosidase activity", "carbohydrate catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF016302", "PTHR12145" ]

[ "Man_a_manosd", "" ]

[ 5651, 7157 ]

2

[ "EC" ]

[ "3.2.1.101" ]

[ "EC:3.2.1.101" ]

1

[ "6ry0", "6ry1", "6ry2", "6ry5", "6ry6", "6ry7" ]

6

[ "PUB00092649" ]

[ "12421307" ]

[ "Two homologous genes, DCW1 (YKL046c) and DFG5, are essential for cell growth and encode glycosylphosphatidylinositol (GPI)-anchored membrane proteins required for cell wall biogenesis in Saccharomyces cerevisiae." ]

[ 2002 ]

1

[ "IPR005198" ]

[]

1

0

1

[ "Eukaryota", "Pseudomonadati" ]

[ 7176, 3 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 7, 2, 3 ]

3

true

Family

Mannan endo-1,6-alpha-mannosidase

Mannan-1_6-alpha_mannosidase

3

IPR014481

14,481

Uncharacterised conserved protein UCP016662, toprim-type

UCP016662_toprim

Family

19

false

Members of this group contain the Toprim domain (topoisomerase-primase) common to DnaG primases, type IA and type II topoisomerases, OLD family nucleases, as well as small primase-like proteins from bacteria and archaea, and bacterial DNA repair proteins of the RecR/M family [ ]. The domain consists of approximately 10...

[]

0

[ "PIRSF" ]

[ "PIRSF016662" ]

[ "UCP016662_Toprim" ]

[ 19 ]

1

[]

0

[]

0

[ "PUB00004485", "PUB00005780", "PUB00027967" ]

[ "9722641", "9121560", "1618804" ]

[ "Toprim--a conserved catalytic domain in type IA and II topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins.", "An atypical topoisomerase II from Archaea with implications for meiotic recombination.", "A common sequence motif, -E-G-Y-A-T-A-, identified within the primase domains of plasmi...

[ 1998, 1997, 1992 ]

3

[]

0

null

[ "Methanobacteriota" ]

[ 19 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP016662, toprim-type

UCP016662_toprim

5

IPR014483

14,483

Fis-like DNA-binding domain-containing signal transduction response regulator, predicted

Sig_transdc_resp-reg_prd

Family

229

false

Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions [ ]. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk [ ]. These pathways have been adapt...

[]

0

[ "PIRSF" ]

[ "PIRSF016788" ]

[ "RR_Fis" ]

[ 229 ]

1

[]

0

[]

0

[ "PUB00010651", "PUB00011096", "PUB00042804", "PUB00042805", "PUB00042806", "PUB00042807" ]

[ "12372152", "10966457", "16176121", "18076326", "11934609", "11489844" ]

[ "Histidine protein kinases: key signal transducers outside the animal kingdom.", "Two-component signal transduction.", "Two-component signal transduction pathways regulating growth and cell cycle progression in a bacterium: a system-level analysis.", "Specificity in two-component signal transduction pathways....

[ 2002, 2000, 2005, 2007, 2002, 2001 ]

6

[]

0

null

[ "Campylobacterales", "hydrothermal vent metagenome" ]

[ 228, 1 ]

2

[]

0

true

Family

Fis-like DNA-binding domain-containing signal transduction response regulator, predicted

Sig_transdc_resp-reg_prd

8

IPR014484

14,484

Uncharacterised conserved protein UCP016792

UCP016792

Family

11

false

This entry represents a small family of archaeal uncharacterised proteins.

[]

0

[ "PIRSF" ]

[ "PIRSF016792" ]

[ "UCP016792" ]

[ 11 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota" ]

[ 11 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP016792

UCP016792

1

IPR014485

14,485

5'-nucleotidase SMN1-like

SMN1-like

Family

2,129

false

This entry represents 5'-nucleotidase SMN1 from Saccharomyces cerevisiae, 5'-nucleotidase efn1 from Schizosaccharomyces pombe and related fungal proteins. These proteins, mainly from ascomycetes but with distant relatives in Giardia intestinalis, contain one copy of the calcineurin-like phosphoesterase domain ( ), foll...

[]

0

[ "PIRSF" ]

[ "PIRSF017316" ]

[ "Pesterase_C1039" ]

[ 2129 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.1.3.5", "3.1.3.91", "PWY-5381", "PWY-5695", "PWY-6596", "PWY-6606", "PWY-6607", "PWY-6608", "PWY-7185", "PWY-7821" ]

[ "EC:3.1.3.5", "EC:3.1.3.91", "METACYC:PWY-5381", "METACYC:PWY-5695", "METACYC:PWY-6596", "METACYC:PWY-6606", "METACYC:PWY-6607", "METACYC:PWY-6608", "METACYC:PWY-7185", "METACYC:PWY-7821" ]

10

[ "3c9f" ]

1

[ "PUB00014394", "PUB00163259" ]

[ "8683579", "35123996" ]

[ "Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures.", "A Similarity-Based Method for Predicting Enzymatic Functions in Yeast Uncovers a New AMP Hydrolase." ]

[ 1996, 2022 ]

2

[ "IPR006179" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2129 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 3 ]

3

true

Family

5'-nucleotidase SMN1-like

SMN1-like

4

IPR014487

14,487

Protein of unknown function DUF3151

DUF3151

Family

3,866

false

This group represents a uncharacterised conserved proteins from enterobacteriaceae.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF11349", "PIRSF017349" ]

[ "DUF3151", "UCP017349" ]

[ 3866, 3666 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 3801, 65 ]

2

[]

0

true

Family

Protein of unknown function DUF3151

DUF3151

2

IPR014488

14,488

Uncharacterised conserved protein UCP017371

UCP017371

Family

1,749

false

This group represents a uncharacterised conserved proteins from enterobacteriaceae.

[]

0

[ "PIRSF" ]

[ "PIRSF017371" ]

[ "UCP017371" ]

[ 1749 ]

1

[]

0

[ "5wox" ]

1

[]

0

[ "IPR019587" ]

[]

1

0

1

[ "Actinomycetota", "freshwater metagenome" ]

[ 1747, 2 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP017371

UCP017371

9

IPR014490

14,490

DNA-binding protein from starved cells-like

Dps-like

Family

2,419

false

The initial member of this family to be characterised was described as a DNA-binding protein from starved cells-like (Dps-like) protein, from the hyperthermophilic acidophile Sulfolobus solfataricus [ ]. The protein was shown to share high sequence similarity with hypothetical proteins in other archaeal and bacterial g...

[]

0

[ "PIRSF" ]

[ "PIRSF018063" ]

[ "Ferrtn_UCP018063" ]

[ 2419 ]

1

[]

0

[ "2clb", "2vzb", "7stw", "8w1d", "8w1e", "8w1f", "9cz0", "9cz8", "9cz9", "9e8s" ]

10

[ "PUB00016871", "PUB00081827" ]

[ "12730463", "16024730" ]

[ "Ferritin: at the crossroads of iron and oxygen metabolism.", "An archaeal antioxidant: characterization of a Dps-like protein from Sulfolobus solfataricus." ]

[ 2003, 2005 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Knufia peltigerae", "metagenomes" ]

[ 190, 2206, 1, 22 ]

4

[]

0

true

Family

DNA-binding protein from starved cells-like

Dps-like

5

IPR014491

14,491

Curli production protein CsgC

Curli_production_prot_CsgC

Family

735

false

Thin aggressive fibres known as curli fibres or fimbriae (curli; Tafi) are cell-surface protein polymers found in Salmonella typhimurium and Escherichia coli that mediate interactions important for host and environmental persistence, development of biofilms, motility, colonisation and invasion of cells, and conjugation...

[]

0

[ "NCBIFAM", "PFAM", "PIRSF" ]

[ "NF007507", "PF10610", "PIRSF018100" ]

[ "PRK10102.1", "Tafi-CsgC", "CsgC" ]

[ 671, 735, 480 ]

3

[]

0

[ "2xsk", "2y2t", "2y2y" ]

3

[ "PUB00027885", "PUB00044511", "PUB00091004", "PUB00104552" ]

[ "9457880", "17379722", "25620560", "27098162" ]

[ "Curli fibers are highly conserved between Salmonella typhimurium and Escherichia coli with respect to operon structure and regulation.", "AgfC and AgfE facilitate extracellular thin aggregative fimbriae synthesis in Salmonella enteritidis.", "The bacterial curli system possesses a potent and selective inhibito...

[ 1998, 2007, 2015, 2016 ]

4

[]

0

null

[ "Bacteria" ]

[ 735 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Curli production protein CsgC

Curli_production_prot_CsgC

9

IPR014492

14,492

Poly(A) polymerase

PolyA_polymerase

Family

5,382

false

Members of this group are poly(A) polymerases (polynucleotide adenylyltransferases, PAP, ). In eukaryotes, polyadenylation of pre-mRNA plays an essential role in the initiation step of protein synthesis, as well as in the export and stability of mRNAs. Poly(A) polymerase, the central enzyme of the polyadenylation machi...

[ "GO:1990817", "GO:0005634" ]

[ "poly(A) RNA polymerase activity", "nucleus" ]

[ "molecular_function", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF018425" ]

[ "PolyA_polymerase" ]

[ 5382 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.7.19", "R-BTA-72187", "R-BTA-72203", "R-BTA-73856", "R-BTA-77595", "R-HSA-72187", "R-HSA-72203", "R-HSA-73856", "R-HSA-77595", "R-MMU-72187", "R-MMU-72203", "R-MMU-73856", "R-MMU-77595" ]

[ "EC:2.7.7.19", "REACTOME:R-BTA-72187", "REACTOME:R-BTA-72203", "REACTOME:R-BTA-73856", "REACTOME:R-BTA-77595", "REACTOME:R-HSA-72187", "REACTOME:R-HSA-72203", "REACTOME:R-HSA-73856", "REACTOME:R-HSA-77595", "REACTOME:R-MMU-72187", "REACTOME:R-MMU-72203", "REACTOME:R-MMU-73856", "REACTOME:R-M...

13

[ "1f5a", "1fa0", "1q78", "1q79", "2hhp", "2o1p", "2q66", "3c66", "4lt6", "7q72", "7q73", "7q74" ]

12

[ "PUB00008708", "PUB00016763", "PUB00016879", "PUB00016881", "PUB00016888" ]

[ "10944102", "10371034", "10357856", "9659922", "1069173" ]

[ "Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATP.", "3'-End processing of pre-mRNA in eukaryotes.", "Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis.", "U1 snRNP inhibits pre-mRNA polyadenylation throu...

[ 2000, 1999, 1999, 1998, 1975 ]

5

[]

0

null

[ "Eukaryota" ]

[ 5382 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 14, 3, 2, 3, 10, 6, 1, 6, 10, 1, 1, 20 ]

12

true

Family

Poly(A) polymerase

PolyA_polymerase

6

IPR014494

14,494

Predicted Fe-S oxidoreductase, NifB/MoaA-like family, euryarchaeota type

Fe-S_OxRdtase_NifB-like_arc

Family

11

false

This group represents a predicted Fe-S oxidoreductase, related to NifB/MoaA family, euryarchaeota type.

[]

0

[ "PIRSF" ]

[ "PIRSF018654" ]

[ "Fe-S_or_NB_arc" ]

[ 11 ]

1

[]

0

[ "9cg2" ]

1

[]

0

[]

0

null

[ "Methanobacteriota" ]

[ 11 ]

1

[]

0

true

Family

Predicted Fe-S oxidoreductase, NifB/MoaA-like family, euryarchaeota type

Fe-S_OxRdtase_NifB-like_arc

4

IPR014495

14,495

Uncharacterised conserved protein UCP018671

UCP018671

Family

600

false

This entry represents a group of integral membrane proteins with unknown function.

[]

0

[ "PIRSF" ]

[ "PIRSF018671" ]

[ "UCP018671" ]

[ 600 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 577, 18, 5 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP018671

UCP018671

7

IPR014496

14,496

Uncharacterised conserved protein UCP018863

UCP018863

Family

35

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF018863" ]

[ "UCP018863" ]

[ 35 ]

1

[]

0

[]

0

[]

0

[ "IPR007503" ]

[]

1

0

1

[ "Thermococcaceae" ]

[ 35 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP018863

UCP018863

1

IPR014497

14,497

Methylmalonyl-CoA decarboxylase, delta subunit

MeMalonyl-CoA_deCOase_dsu

Family

35

false

This group represents the delta subunit of predicted methylmalonyl-CoA decarboxylases found in the archaea; they function as a sodium ion transporters [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF018867" ]

[ "Na_decarb_PF0672" ]

[ 35 ]

1

[]

0

[]

0

[ "PUB00007893" ]

[ "11248185" ]

[ "Sodium ion-translocating decarboxylases." ]

[ 2001 ]

1

[ "IPR005899" ]

[]

1

0

1

[ "Thermococcaceae" ]

[ 35 ]

1

[]

0

true

Family

Methylmalonyl-CoA decarboxylase, delta subunit

MeMalonyl-CoA_deCOase_dsu

4