LiteFold/InterPro · Datasets at Hugging Face

IPR014499

14,499

Diadenylate cyclase, DacZ-type

DAC_DacZ

Family

827

false

Diadenylate cyclase (DAC, also known as diadenylyl cyclase and cyclic-di-AMP synthase) catalyses the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a putative second messenger in bacteria and archaea [ , , ]. DAC proteins contain a DisA_N domain, first identified as a DAC domain in the T. maritima prote...

[]

0

[ "HAMAP", "PIRSF" ]

[ "MF_00840", "PIRSF019073" ]

[ "DacZ", "UCP019073" ]

[ 827, 571 ]

2

[]

0

[]

0

[ "PUB00080710", "PUB00086803", "PUB00086804", "PUB00086805" ]

[ "23812326", "25965978", "22529992", "23760274" ]

[ "Cyclic di-AMP: another second messenger enters the fray.", "RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messenger Cyclic di-AMP.", "Mycobacterium tuberculosis Rv3586 (DacA) is a diadenylate cyclase that converts ATP or ADP into c-di-AMP.", "Radiation-sensitive gene A (RadA) targets DisA,...

[ 2013, 2015, 2012, 2013 ]

4

[]

0

null

[ "Bacteria", "Geodia barretti", "Methanobacteriati", "unclassified sequences" ]

[ 251, 1, 569, 6 ]

4

[]

0

true

Family

Diadenylate cyclase, DacZ-type

DAC_DacZ

5

IPR014500

14,500

Uncharacterised conserved protein UCP019307, cupin-type

UCP019307_cupin

Family

2,826

false

This group contains proteins with the conserved barrel domain of the cupin superfamily (cupin fold) [ , , , ]. There are currently no experimental data for members of this group.

[]

0

[ "PIRSF" ]

[ "PIRSF019307" ]

[ "UCP019307" ]

[ 2826 ]

1

[]

0

[]

0

[ "PUB00007275", "PUB00007276", "PUB00007277", "PUB00016787" ]

[ "11738598", "11264412", "10704478", "14697267" ]

[ "Evolution of functional diversity in the cupin superfamily.", "Phylogeny, function, and evolution of the cupins, a structurally conserved, functionally diverse superfamily of proteins.", "Microbial relatives of the seed storage proteins of higher plants: conservation of structure and diversification of functio...

[ 2001, 2001, 2000, 2004 ]

4

[ "IPR047121" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2139, 684, 3 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP019307, cupin-type

UCP019307_cupin

3

IPR014501

14,501

Uncharacterised conserved protein UCP019317

UCP019317

Family

4

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF019317" ]

[ "UCP019317" ]

[ 4 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Thermococcaceae" ]

[ 4 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP019317

UCP019317

9

IPR014503

14,503

Clavaminate synthase-like

Clavaminate_syn-like

Family

1,806

false

This entry includes clavaminate synthases and related proteins from bacteria. Proteins in this entry include VioC from Streptomyces vinaceus, MppO from Streptomyces hygroscopicus and AsnO from Streptomyces coelicolor. They are non-heme iron, alpha-ketoglutarate-dependent oxygenases. VioC catalyses Fe(II)-dependent and ...

[ "GO:0005506", "GO:0016491" ]

[ "iron ion binding", "oxidoreductase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PIRSF" ]

[ "PIRSF019543" ]

[ "Clavaminate_syn" ]

[ 1806 ]

1

[]

0

[ "1drt", "1dry", "1ds0", "1ds1", "1gvg", "2og5", "2og6", "2og7", "2wbo", "2wbp", "2wbq", "4m23", "4m25", "4m26", "4m27", "4m2c", "4m2e", "4m2f", "4m2g", "4m2i", "4ne0", "6alm", "6aln", "6alo", "6alp", "6alq", "6alr", "6daw", "6dax", "6daz", "6db2", "6f2a"...

49

[ "PUB00042184", "PUB00050101", "PUB00078089" ]

[ "17373765", "19490124", "16298295" ]

[ "Mechanistic and structural basis of stereospecific Cbeta-hydroxylation in calcium-dependent antibiotic, a daptomycin-type lipopeptide.", "Structural basis for the erythro-stereospecificity of the l-arginine oxygenase VioC in viomycin biosynthesis.", "Investigating beta-hydroxyenduracididine formation in the bi...

[ 2007, 2009, 2005 ]

3

[]

[ "IPR023966" ]

0

1

0

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1777, 10, 19 ]

3

[]

0

true

Family

Clavaminate synthase-like

Clavaminate_syn-like

7

IPR014505

14,505

UMP-CMP kinase 2, mitochondrial

UMP-CMP_kinase_2

Family

580

false

This group represents a UMP-CMP kinase, mitochondrial-type. It is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogues ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor [ ].

[ "GO:0050145" ]

[ "nucleoside monophosphate kinase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF019736" ]

[ "dTMP_TKRP1" ]

[ 580 ]

1

[]

0

[]

0

[ "PUB00089684" ]

[ "17999954" ]

[ "Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria." ]

[ 2008 ]

1

[]

0

null

[ "Eukaryota" ]

[ 580 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3 ]

3

true

Family

UMP-CMP kinase 2, mitochondrial

UMP-CMP_kinase_2

5

IPR014506

14,506

Uncharacterised conserved protein UCP020479, signal transduction CheW-like

UCP020479_CheW

Family

1,777

false

Members of this group of proteins from Proteobacteria contain a CheW-like chemotaxis signal transduction domain and an uncharacterised N-terminal domain. They are predicted to be signal transduction proteins, possibly involved in chemotaxis. The N-terminal domain is distantly related to periplasmic/solute binding domai...

[]

0

[ "PIRSF" ]

[ "PIRSF020479" ]

[ "UCP020479_CheW" ]

[ 1777 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1765, 12 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP020479, signal transduction CheW-like

UCP020479_CheW

4

IPR014507

14,507

Baseplate assembly protein J, predicted

Baseplate_assembly_J_pred

Family

5,499

false

The temperate bacteriophage P2 has four defined tail genes: V, J, W and I. Their order is the late gene promoter, VWJI, followed by the tail fibre genes H and G and then a transcription terminator. BAP V protein is the small spike at the tip of the tail and basal plate assembly protein J lies at the edge of the basepla...

[]

0

[ "PIRSF" ]

[ "PIRSF020481" ]

[ "BAP" ]

[ 5499 ]

1

[]

0

[ "6u5b", "6u5k" ]

2

[ "PUB00008577" ]

[ "7483254" ]

[ "Bacteriophage P2: genes involved in baseplate assembly." ]

[ 1995 ]

1

[]

0

null

[ "Arthropoda", "Bacteria", "Viruses", "metagenomes" ]

[ 5, 5302, 182, 10 ]

4

[]

0

true

Family

Baseplate assembly protein J, predicted

Baseplate_assembly_J_pred

1

IPR014508

14,508

Uncharacterised conserved protein withTPR-like repeats

UCP020555_TPR-like

Family

1,639

false

This family of proteins is found in bacteria. There is a conserved PES sequence motif. They are putative lipoproteins.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF16068", "PIRSF020555" ]

[ "DUF4810", "UCP020555" ]

[ 1639, 1342 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 1619, 3, 17 ]

3

[]

0

true

Family

Uncharacterised conserved protein withTPR-like repeats

UCP020555_TPR-like

1

IPR014510

14,510

Tellurite resistance predicted, YeaR

Tellurite-R_YeaR

Family

1,642

false

Proteins in this group are stand-alone YeaR proteins, the predication is based on domain association, and is known to be involved in tellurite resistance. Tellurite resistance protein TehB is encoded by the tellurite-reducing operon tehAB [ ]. TehB exists in a two-domain form ( ) with a C-terminal SAM-dependent methylt...

[]

0

[ "PIRSF" ]

[ "PIRSF020632" ]

[ "YeaR" ]

[ 1642 ]

1

[]

0

[ "3bb6", "3dl3" ]

2

[ "PUB00014885", "PUB00027707", "PUB00027741" ]

[ "11053398", "10339832", "11032735" ]

[ "Escherichia coli TehB requires S-adenosylmethionine as a cofactor to mediate tellurite resistance.", "Characterization of gram-positive tellurite resistance encoded by the Streptococcus pneumoniae tehB gene.", "The role of cysteine residues in tellurite resistance mediated by the TehAB determinant." ]

[ 2000, 1999, 2000 ]

3

[]

0

null

[ "Bacteria", "Opisthokonta", "human gut metagenome" ]

[ 1639, 2, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Tellurite resistance predicted, YeaR

Tellurite-R_YeaR

6

IPR014511

14,511

Protein of unknown function DUF2068, transmembrane, subgroup

DUF2068_TM_subgr

Family

186

false

This entry, found in various prokaryotic proteins, has no known function, but contains at least two predicted transmembrane regions.

[]

0

[ "PIRSF" ]

[ "PIRSF021485" ]

[ "UCP021485" ]

[ 186 ]

1

[]

0

[]

0

[]

0

[ "IPR021125" ]

[]

1

0

1

[ "Bacteria" ]

[ 186 ]

1

[]

0

true

Family

Protein of unknown function DUF2068, transmembrane, subgroup

DUF2068_TM_subgr

2

IPR014512

14,512

Predicted O-glycosyl hydrolase

O_gly_hydro

Family

2,396

false

This group represents a predicted O-glycosyl hydrolase.

[]

0

[ "PIRSF" ]

[ "PIRSF021505" ]

[ "O_gly_hdrol" ]

[ 2396 ]

1

[]

0

[ "3k7x", "4boj", "4bok", "4c1s", "4d4a", "4d4b", "4d4c", "4d4d", "4mu9", "5agd", "5n0f", "6shd", "6shm", "6y8f", "6zbm", "6zbw", "6zbx", "7nl5" ]

18

[]

0

[ "IPR005198" ]

[]

1

0

1

[ "Bacteria", "Diaporthe", "Haladaptatus pallidirubidus", "metagenomes" ]

[ 2386, 2, 1, 7 ]

4

[]

0

true

Family

Predicted O-glycosyl hydrolase

O_gly_hydro

4

IPR014513

14,513

Uncharacterised conserved protein UCP021525

UCP021525

Family

182

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF021525" ]

[ "UCP021525" ]

[ 182 ]

1

[]

0

[]

0

[]

0

[ "IPR014942" ]

[]

1

0

1

[ "Bacteria", "unclassified sequences" ]

[ 179, 3 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP021525

UCP021525

8

IPR014514

14,514

Uncharacterised conserved protein UCP021940

UCP021940

Family

145

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09974", "PIRSF021940" ]

[ "DUF2209", "UCP021940" ]

[ 145, 56 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota", "ecological metagenomes" ]

[ 143, 2 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP021940

UCP021940

5

IPR014515

14,515

Uncharacterised conserved protein UCP921964

UCP921964

Family

90

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09893", "PIRSF021964" ]

[ "DUF2120", "UCP921964" ]

[ 90, 63 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Methanomada group", "Zygosaccharomyces bailii (strain CLIB 213 / ATCC 58445 / CBS 680 / BCRC 21525 / NBRC 1098 / NCYC 1416 / NRRL Y-2227)", "bioreactor metagenome" ]

[ 88, 1, 1 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP921964

UCP921964

9

IPR014517

14,517

ArsR transcriptional regulator

ArsR_tscrpt_regulator

Family

184

false

Members of this family of archaeal proteins are conserved transcriptional regulators belonging to the ArsR family.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09824", "PIRSF022057" ]

[ "ArsR", "UCP022057" ]

[ 184, 144 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriati", "ecological metagenomes" ]

[ 168, 16 ]

2

[]

0

true

Family

ArsR transcriptional regulator

ArsR_tscrpt_regulator

4

IPR014519

14,519

Uncharacterised conserved protein UCP024492

UCP024492

Family

3,831

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF024492" ]

[ "UCP024492" ]

[ 3831 ]

1

[]

0

[]

0

[]

0

[ "IPR007438" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 124, 3646, 30, 8, 23 ]

5

[]

0

true

Family

Uncharacterised conserved protein UCP024492

UCP024492

7

IPR014522

14,522

Archaeosortase A

ArtA

Family

536

false

This family is an archaeal variant of the (normally bacterial) putative protein-sorting integral membrane protein exosortase, hence archaeosortase. The PGF-CTERM/archaeosortase A system is related to S-layer (surface layer) production [ ]. Moreover, it has been shown that archaeosortase A (ArtA) is involved in carboxy-...

[]

0

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF025737", "TIGR04125" ]

[ "Cyco1", "exosort_PGF_TRM" ]

[ 479, 536 ]

2

[ "GP" ]

[ "GenProp0978" ]

[ "GP:GenProp0978" ]

1

[]

0

[ "PUB00060405", "PUB00093713" ]

[ "22037399", "23651326" ]

[ "Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification.", "Haloferax volcanii archaeosortase is required for motility, mating, and C-terminal processing of the S-layer glycoprotein." ]

[ 2012, 2013 ]

2

[ "IPR019127" ]

[]

1

0

1

[ "Methanobacteriati", "unclassified sequences" ]

[ 526, 10 ]

2

[]

0

true

Family

Archaeosortase A

ArtA

3

IPR014524

14,524

Outer membrane protein assembly factor BamC

BamC

Family

1,990

false

Outer membrane protein (OMP) assembly factor BamC is part of the outer membrane protein assembly Bam complex (composed of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE), which is involved in assembly and insertion of β-barrel proteins into the outer membrane [ , , , , ]. E. coli BamC ...

[]

0

[ "HAMAP", "PIRSF" ]

[ "MF_00924", "PIRSF026343" ]

[ "OM_assembly_BamC", "NlpB" ]

[ 1987, 1721 ]

2

[ "GP", "REACTOME" ]

[ "GenProp1116", "R-HSA-9760173" ]

[ "GP:GenProp1116", "REACTOME:R-HSA-9760173" ]

2

[ "3tgo", "5d0o", "5d0q", "5ekq", "6lyq", "6lyr", "6lys", "6lyu", "6v05", "7bnq", "7nbx", "7ncs", "7nd0", "7nri", "7r1w", "7ri4", "7ri5", "7ri6", "7ri7", "7ri8", "7ri9", "7rj5", "7tsz", "7tt0", "7tt1", "7tt2", "7tt3", "7tt4", "7tt5", "7tt6", "7tt7", "7ttc"...

67

[ "PUB00043080", "PUB00059811", "PUB00060769", "PUB00060770", "PUB00060771", "PUB00060776" ]

[ "16824102", "21586578", "20378773", "21823654", "22281737", "22178970" ]

[ "YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli.", "Structural basis of outer membrane protein biogenesis in bacteria.", "Reconstitution of outer membrane protein assembly from purified components.", "The reconstituted Escherichia coli Bam complex cat...

[ 2006, 2011, 2010, 2011, 2012, 2012 ]

6

[ "IPR010653" ]

[]

1

0

1

[ "Bacteria", "Beauveria bassiana D1-5", "marine sediment metagenome" ]

[ 1988, 1, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Outer membrane protein assembly factor BamC

BamC

2

IPR014525

14,525

Ethylene receptor

ETR

Family

1,780

false

This entry represents hybrid ethylene sensor histidine kinases from plants, also known as ethylene receptors. It includes ETR1, ETR2, and EIN4 from Arabidopsis thaliana, all of which contain a receiver domain at the C terminus. ETR1 has His kinase activity, whereas ETR2 and EIN4 have Ser/Thr kinase activity [ ]. They a...

[ "GO:0004672", "GO:0038199", "GO:0051740", "GO:0009723", "GO:0005789" ]

[ "protein kinase activity", "ethylene receptor activity", "ethylene binding", "response to ethylene", "endoplasmic reticulum membrane" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

5

[ "PIRSF" ]

[ "PIRSF026389" ]

[ "Ethyln_sen_HK" ]

[ 1780 ]

1

[ "EC" ]

[ "2.7.13.3" ]

[ "EC:2.7.13.3" ]

1

[]

0

[ "PUB00076421", "PUB00089920" ]

[ "15703053", "29158332" ]

[ "Ethylene-binding activity, gene expression levels, and receptor system output for ethylene receptor family members from Arabidopsis and tomato.", "Ethylene Receptors Signal via a Noncanonical Pathway to Regulate Abscisic Acid Responses." ]

[ 2005, 2018 ]

2

[]

0

null

[ "Streptophyta" ]

[ 1780 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 12, 4, 15 ]

3

true

Family

Ethylene receptor

ETR

6

IPR014527

14,527

Excinuclease GIY-YIG catalytic domain-containing uncharacterised conserved protein

UCP026568_excinuclease

Family

609

false

This group represents a predicted uncharacterised protein with excinuclease GIY-YIG catalytic domain.

[]

0

[ "PIRSF" ]

[ "PIRSF026568" ]

[ "UCP026568" ]

[ 609 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "Rhizophagus irregularis" ]

[ 608, 1 ]

2

[]

0

true

Family

Excinuclease GIY-YIG catalytic domain-containing uncharacterised conserved protein

UCP026568_excinuclease

9

IPR014528

14,528

Cyclic-di-AMP phosphodiesterase GdpP/PdeA

GdpP/PdeA

Family

4,717

false

This entry includes a group of cyclic-di-AMP phosphodiesterases, including GdpP (also known as yybT) from Bacillus subtilis and PdeA from Listeria monocytogenes serotype 1/2a. They contribute to the degradation of cyclic di-AMP (c-di-AMP), which controls cell wall and potassium homeostasis and secures the integrity of ...

[]

0

[ "PIRSF" ]

[ "PIRSF026583" ]

[ "YybT" ]

[ 4717 ]

1

[ "EC" ]

[ "3.1.4.59" ]

[ "EC:3.1.4.59" ]

1

[]

0

[ "PUB00078858", "PUB00078859" ]

[ "26240071", "23716572" ]

[ "An Essential Poison: Synthesis and Degradation of Cyclic Di-AMP in Bacillus subtilis.", "Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection." ]

[ 2015, 2013 ]

2

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 4712, 5 ]

2

[]

0

true

Family

Cyclic-di-AMP phosphodiesterase GdpP/PdeA

GdpP/PdeA

7

IPR014529

14,529

Uncharacterised conserved protein UCP026631

UCP026631

Family

7,573

false

This group represents a predicted membrane protein.

[]

0

[ "PIRSF" ]

[ "PIRSF026631" ]

[ "UCP026631" ]

[ 7573 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "metagenomes" ]

[ 288, 7272, 13 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP026631

UCP026631

1

IPR014535

14,535

Predicted heptaprenyl diphosphate synthase, component I

Hpre_diP_synt_I

Family

2,584

false

Proteins in this group all contain a domain that is predicted to be component I of bacterial heptaprenyl diphosphate (HepPP) synthase ( ). In Bacillus subtilis the enzyme is composed of two dissociable subunits, component I and component II; both are essential for enzyme catalysis [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF027391" ]

[ "Hpre_diP_synt_I" ]

[ 2584 ]

1

[]

0

[]

0

[ "PUB00013095" ]

[ "9748348" ]

[ "Two subunits of heptaprenyl diphosphate synthase of Bacillus subtilis form a catalytically active complex." ]

[ 1998 ]

1

[ "IPR010898" ]

[]

1

0

1

[ "Bacteria", "unclassified sequences" ]

[ 2542, 42 ]

2

[]

0

true

Family

Predicted heptaprenyl diphosphate synthase, component I

Hpre_diP_synt_I

9

IPR014536

14,536

Sorting nexin 9 family

Snx9_fam

Family

3,553

false

Proteins in the sorting nexin 9 subfamily includes SNX9, SNX18 and SNX33 [ ]. They are characterised by the presence of an N-terminal SH3 domain ( ), a PX domain that is a phosphoinositide-binding module ( ), and a Bin/Amphiphysin/Rvs (BAR) domain at the C terminus, which allows membrane binding and bending. They are r...

[ "GO:0000278", "GO:0015031" ]

[ "mitotic cell cycle", "protein transport" ]

[ "biological_process", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF027744" ]

[ "Snx9" ]

[ 3553 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-432722", "R-CEL-8856828", "R-HSA-432722", "R-HSA-8856828", "R-MMU-432722", "R-MMU-8856828" ]

[ "REACTOME:R-CEL-432722", "REACTOME:R-CEL-8856828", "REACTOME:R-HSA-432722", "REACTOME:R-HSA-8856828", "REACTOME:R-MMU-432722", "REACTOME:R-MMU-8856828" ]

6

[]

0

[ "PUB00068939", "PUB00068942", "PUB00068943" ]

[ "14752159", "22718350", "2271835" ]

[ "Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development.", "SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis.", "Guidelines for management of asthma." ]

[ 2004, 2012, 1990 ]

3

[]

0

null

[ "Bilateria" ]

[ 3553 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 9, 1, 11, 8, 9 ]

6

true

Family

Sorting nexin 9 family

Snx9_fam

2

IPR014537

14,537

Uncharacterised conserved protein UCP027893

UCP027893

Family

46

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF027893" ]

[ "UCP027893" ]

[ 46 ]

1

[]

0

[]

0

[]

0

[ "IPR007841" ]

[]

1

0

1

[ "Thermoprotei" ]

[ 46 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP027893

UCP027893

6

IPR014538

14,538

Uncharacterised conserved protein, topoisomerase zinc finger

UCP028063_topo_Znf

Family

432

false

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b...

[]

0

[ "PIRSF" ]

[ "PIRSF028063" ]

[ "UCP028063" ]

[ 432 ]

1

[]

0

[]

0

[ "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812" ]

[ "12665246", "17210253", "15963892", "15718139", "10529348", "11179890" ]

[ "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on RNA.", "Zinc finger peptides for the regulation of gene expression.", "Zinc finger proteins: new ...

[ 2002, 2007, 2005, 2005, 1999, 2001 ]

6

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 430, 2 ]

2

[]

0

true

Family

Uncharacterised conserved protein, topoisomerase zinc finger

UCP028063_topo_Znf

8

IPR014540

14,540

Uncharacterised conserved protein UCP028175

UCP028175

Family

42

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in Vibrio species.

[]

0

[ "PIRSF" ]

[ "PIRSF028175" ]

[ "UCP028175" ]

[ 42 ]

1

[]

0

[]

0

[]

0

[ "IPR060032" ]

[]

1

0

1

[ "Vibrio" ]

[ 42 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP028175

UCP028175

4

IPR014541

14,541

Predicted amidinotransferase, FN0238 type

Amdntrnsf_FN0238

Family

3,689

false

This group represents a predicted amidinotransferase, FN0238 type. Please see the following relevant reference: [ ].

[]

0

[ "NCBIFAM", "PIRSF", "PANTHER" ]

[ "NF046062", "PIRSF028188", "PTHR43224" ]

[ "citrull_CtlX", "Amdntrnsf_FN0238", "" ]

[ 2955, 3273, 3688 ]

3

[]

0

[]

0

[ "PUB00019133", "PUB00159511" ]

[ "9218780", "35417463" ]

[ "Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis.", "Filling gaps in bacterial catabolic pathways with computation and high-throughput genetics." ]

[ 1997, 2022 ]

2

[]

0

null

[ "Bacteria", "Candidatus Parvarchaeum acidiphilum ARMAN-4", "Eukaryota", "unclassified sequences" ]

[ 3397, 1, 248, 43 ]

4

[]

0

true

Family

Predicted amidinotransferase, FN0238 type

Amdntrnsf_FN0238

3

IPR014543

14,543

Uncharacterised conserved protein UCP028291

UCP028291

Family

3,398

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09981", "PIRSF028291" ]

[ "DUF2218", "UCP028291" ]

[ 3398, 1700 ]

2

[]

0

[ "2jpi" ]

1

[]

0

[]

0

null

[ "Bacteria", "Diploscapter pachys", "unclassified sequences", "uncultured virus" ]

[ 3387, 1, 9, 1 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP028291

UCP028291

1

IPR014544

14,544

Uncharacterised conserved protein UCP028408

UCP028408

Family

1,172

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF028408" ]

[ "UCP028408" ]

[ 1172 ]

1

[]

0

[ "7til", "8q72" ]

2

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 1153, 19 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP028408

UCP028408

5

IPR014545

14,545

Uncharacterised conserved protein UCP028415

UCP028415

Family

310

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF028415" ]

[ "UCP028415" ]

[ 310 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Knufia peltigerae", "Pseudomonadota" ]

[ 1, 309 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP028415

UCP028415

6

IPR014547

14,547

Uncharacterised conserved protein UCP028477

UCP028477

Family

1,359

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09916", "PIRSF028477" ]

[ "DUF2145", "UCP028477" ]

[ 1359, 1020 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "bioreactor metagenome" ]

[ 1356, 2, 1 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP028477

UCP028477

5

IPR014548

14,548

Predicted acyltransferase

Ac_Trasf

Family

2,103

false

This group represents a predicted acyltransferase.

[]

0

[ "PIRSF" ]

[ "PIRSF028561" ]

[ "Ac_Trasf" ]

[ 2103 ]

1

[]

0

[]

0

[]

0

[ "IPR004960" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 2078, 25 ]

2

[]

0

true

Family

Predicted acyltransferase

Ac_Trasf

7

IPR014549

14,549

Flagellar protein FlgO

FlgO

Family

782

false

This family includes FlgO from Vibrio cholerae, which is part of an operon with two genes, flgO and flgP, positively regulated by FlrC, the activator of class III flagellar genes [ ]. FlgO and FlgP function in motility to mediate flagellar stability and influence attachment and colonization [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF028688" ]

[ "UCP_imp_028688" ]

[ 782 ]

1

[]

0

[]

0

[ "PUB00078827", "PUB00078828" ]

[ "17981980", "19592588" ]

[ "Lipidation of an FlrC-dependent protein is required for enhanced intestinal colonization by Vibrio cholerae.", "Characterization of two outer membrane proteins, FlgO and FlgP, that influence vibrio cholerae motility." ]

[ 2008, 2009 ]

2

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 774, 8 ]

2

[]

0

true

Family

Flagellar protein FlgO

FlgO

9

IPR014551

14,551

Beta-glucosidase GBA2-type

B_Glucosidase_GBA2-typ

Family

3,378

false

Non-lysosomal glucosylceramidase, also known as beta-glucosidase 2 (GBA2) is an enzyme involved in an alternative catabolic pathway of glucosylceramide [ ]. GBA2, has been characterised as a bile acid beta-glucosidase [ ]. It is unrelated to other known glucosidases, but it has homologues among bacteria and archaea [ ]...

[ "GO:0004348", "GO:0006680", "GO:0016020" ]

[ "glucosylceramidase activity", "glucosylceramide catabolic process", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF028944" ]

[ "Beta_gluc_GBA2" ]

[ 3378 ]

1

[ "EC", "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", ...

[ "2.4.1.-", "3.2.1.-", "3.2.1.45", "3.2.1.46", "PWY-1901", "PWY-1921", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286"...

[ "EC:2.4.1.-", "EC:3.2.1.-", "EC:3.2.1.45", "EC:3.2.1.46", "METACYC:PWY-1901", "METACYC:PWY-1921", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC...

234

[ "5bvu", "5bx2", "5bx3", "5bx4", "5bx5", "5fjs", "5npf", "5o0s", "5ost", "7dks", "7dkt", "7dku", "7dkv", "7dkw", "7dkx", "7dky", "7w2s", "7w2t", "7w2v", "7w2w", "7w2x", "8i5o", "8i5p", "8i5q", "8i5r", "8i5s", "8i5t", "8i5u", "8jbo", "8r06", "8r1m" ]

31

[ "PUB00027918", "PUB00044658", "PUB00073615" ]

[ "11489889", "17105727", "20427274" ]

[ "Molecular cloning and expression of human bile acid beta-glucosidase.", "Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2.", "A new archaeal beta-glycosidase from Sulfolobus solfataricus: seeding a novel retaining beta-glycan-specific glycoside hydrolase family along with the human ...

[ 2001, 2007, 2010 ]

3

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 327, 3051 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 25, 4, 1, 3, 3, 1, 12, 3, 19 ]

9

true

Family

Beta-glucosidase GBA2-type

B_Glucosidase_GBA2-typ

6

IPR014553

14,553

Predicted aminopeptidase

Aminopept

Family

2,369

false

This family of bacterial proteins has a conserved HEXXH motif, suggesting that members are putative peptidases of zincin fold [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10023", "PIRSF029285" ]

[ "Aminopep", "Aminopept" ]

[ 2369, 2036 ]

2

[]

0

[]

0

[ "PUB00075429" ]

[ "23671590" ]

[ "CLCAs - a family of metalloproteases of intriguing phylogenetic distribution and with cases of substituted catalytic sites." ]

[ 2013 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 2317, 6, 46 ]

3

[]

0

true

Family

Predicted aminopeptidase

Aminopept

7

IPR014555

14,555

RecF-like

Family

6,906

false

This group represents a predicted RecF protein.

[]

0

[ "PIRSF" ]

[ "PIRSF029347" ]

[ "RecF" ]

[ 6906 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Caudoviricetes", "Eukaryota", "metagenomes" ]

[ 117, 6718, 2, 8, 61 ]

5

[]

0

true

Family

RecF-like

8

IPR014556

14,556

Uncharacterised conserved protein UCP029407

UCP029407

Family

349

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF029407" ]

[ "UCP029407" ]

[ 349 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 344, 5 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP029407

UCP029407

5

IPR014557

14,557

Uncharacterised conserved protein UCP029548, STAS-type

UCP029548_STAS-type

Family

1,240

false

This group represents a predicted uncharacterised protein with STAS domain, PA2797 type.

[]

0

[ "NCBIFAM", "PIRSF" ]

[ "NF045506", "PIRSF029548" ]

[ "antisigant_RssC_Pseudo", "UCP029548" ]

[ 682, 1240 ]

2

[]

0

[]

0

[ "PUB00153448" ]

[ "37328957" ]

[ "Defining the regulatory mechanisms of sigma factor RpoS degradation in Azotobacter vinelandii and Pseudomonas aeruginosa." ]

[ 2023 ]

1

[]

0

null

[ "Pseudomonadota", "metagenomes" ]

[ 1233, 7 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP029548, STAS-type

UCP029548_STAS-type

5

IPR014558

14,558

Uncharacterised conserved lipoprotein

UCP029720

Family

2,539

false

There is currently no experimental data for members of this group of lipoproteins or their homologues, nor do they exhibit features indicative of any function.

[]

0

[ "PIRSF" ]

[ "PIRSF029720" ]

[ "UCP029720" ]

[ 2539 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2532, 3, 4 ]

3

[]

0

true

Family

Uncharacterised conserved lipoprotein

UCP029720

6

IPR014560

14,560

Uncharacterised conserved protein UCP030333, DNA/RNA-binding Alba-related

UCP030333_Alba

Family

2,609

false

This entry represents a group of proteins from plants and lower eukaryotes that are related to the archaeal DNA/RNA-binding protein Alba, also called histone-like protein ( ), and its eukaryotic homologues RNase P/MRP subunits Pop7/Rpp20 ( ) and Rpp25. Members of this family are the uncharacterised protein At2g34160 fr...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF030333", "PTHR31947" ]

[ "UCP030333_Alba", "" ]

[ 1751, 2609 ]

2

[]

0

[ "1vm0", "2q3v", "7dl8" ]

3

[ "PUB00019120", "PUB00022778", "PUB00027864", "PUB00153038", "PUB00153039", "PUB00153040" ]

[ "14519199", "12837780", "14651642", "22167473", "30576513", "36947546" ]

[ "The two faces of Alba: the evolutionary connection between proteins participating in chromatin structure and RNA metabolism.", "Crystal structure of the hyperthermophilic archaeal DNA-binding protein Sso10b2 at a resolution of 1.85 Angstroms.", "Ssh10b, a conserved thermophilic archaeal protein, binds RNA in v...

[ 2003, 2003, 2003, 2012, 2019, 2023 ]

6

[]

0

null

[ "Eukaryota" ]

[ 2609 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 9, 9, 32 ]

3

true

Family

Uncharacterised conserved protein UCP030333, DNA/RNA-binding Alba-related

UCP030333_Alba

4

IPR014562

14,562

Uncharacterised conserved protein UCP030959, divergent TPR repeat-containing

UCP030959_TPR_rpt-cont

Family

1,089

false

The proteins in this family contain a divergent form of TPR repeats. Their function is unknown.

[]

0

[ "PIRSF" ]

[ "PIRSF030959" ]

[ "UCP030959" ]

[ 1089 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 1077, 12 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP030959, divergent TPR repeat-containing

UCP030959_TPR_rpt-cont

6

IPR014564

14,564

Uncharacterised conserved protein UCP031503, transmembrane

UCP031503_TM

Family

1,300

false

There is currently no experimental data for members of this group of predicted transmembrane proteins or their homologues, nor do they exhibit features indicative of any function.

[]

0

[ "PIRSF" ]

[ "PIRSF031503" ]

[ "UCP031503_mp" ]

[ 1300 ]

1

[]

0

[]

0

[]

0

[ "IPR012507" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 1297, 3 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP031503, transmembrane

UCP031503_TM

7

IPR014565

14,565

Exopolysaccharide biosynthesis, EpsL, firmicutes

EpsL_firmicutes

Family

311

false

This group represents an exopolysaccharide biosynthesis protein and is restricted to Firmicutes.

[]

0

[ "PIRSF" ]

[ "PIRSF031512" ]

[ "EpsL" ]

[ 311 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati", "bioreactor metagenome" ]

[ 309, 2 ]

2

[]

0

true

Family

Exopolysaccharide biosynthesis, EpsL, firmicutes

EpsL_firmicutes

2

IPR014567

14,567

Uncharacterised conserved protein UCP031900

UCP031900

Family

2,061

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF031900" ]

[ "UCP031900" ]

[ 2061 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2035, 6, 20 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP031900

UCP031900

2

IPR014569

14,569

Ubiquinol-cytochrome c chaperone, CBP3-related

Ubq_cyt-c_CBP3-rel

Family

1,186

false

This entry represents a family of proteins from Alphaproteobacteria that display similarity to a chaperone identified in Saccharomyces cerevisiae ( ), which plays a key role in the assembly of ubiquinol-cytochrome-c reductase. The crystal structure of this protein has been resolved in the homologue from the Brucella ab...

[]

0

[ "PIRSF" ]

[ "PIRSF032079" ]

[ "UCP032079" ]

[ 1186 ]

1

[]

0

[ "6rwt" ]

1

[ "PUB00020512", "PUB00020513", "PUB00100678" ]

[ "2544586", "11522252", "31537648" ]

[ "Identification and characterization of a new gene (CBP3) required for the expression of yeast coenzyme QH2-cytochrome c reductase.", "Identification of functional regions of Cbp3p, an enzyme-specific chaperone required for the assembly of ubiquinol-cytochrome c reductase in yeast mitochondria.", "Structural ba...

[ 1989, 2001, 2019 ]

3

[ "IPR007129" ]

[]

1

0

1

[ "Pseudomonadati", "ecological metagenomes" ]

[ 1181, 5 ]

2

[]

0

true

Family

Ubiquinol-cytochrome c chaperone, CBP3-related

Ubq_cyt-c_CBP3-rel

5

IPR014570

14,570

Encapsidation protein CP3

Encapsidation_CP3

Family

159

false

Staphylococcus aureus pathogenicity islands (SaPIs) are highly mobile phage-related pathogenicity islands that typically carry genes for one or more superantigens. They are the primary cause of superantigen-induced diseases, especially toxic shock syndrome. SaPIs are induced to excise and replicate by the presence of a...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27666", "PIRSF032437" ]

[ "Encapsidation_CP3", "UCP032437" ]

[ 159, 54 ]

2

[]

0

[]

0

[ "PUB00056592", "PUB00056593" ]

[ "18223072", "17581119" ]

[ "Staphylococcus aureus pathogenicity island DNA is packaged in particles composed of phage proteins.", "SaPI operon I is required for SaPI packaging and is controlled by LexA." ]

[ 2008, 2007 ]

2

[]

0

null

[ "Bacillales", "human gut metagenome", "uncultured Caudovirales phage" ]

[ 155, 1, 3 ]

3

[]

0

true

Family

Encapsidation protein CP3

Encapsidation_CP3

5

IPR014572

14,572

Uncharacterised conserved protein UCP032673

UCP032673

Family

21

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF032673" ]

[ "UCP032673" ]

[ 21 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Thermoprotei" ]

[ 21 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP032673

UCP032673

4

IPR014573

14,573

Uncharacterised conserved protein UCP032806

UCP032806

Family

21

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF032806" ]

[ "UCP032806" ]

[ 21 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Thermoprotei" ]

[ 21 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP032806

UCP032806

1

IPR014574

14,574

Uncharacterised conserved protein UCP032908

UCP032908

Family

412

false

There is currently no experimental data for members of this group of proteins or their homologues, nor do they exhibit features indicative of any function. However, they are predicted to be membrane proteins.

[]

0

[ "PIRSF" ]

[ "PIRSF032908" ]

[ "UCP032908" ]

[ 412 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacillati", "bioreactor metagenome" ]

[ 23, 388, 1 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP032908

UCP032908

8

IPR014575

14,575

Type III secretion system, secreted protein EspD

T3SS_EspD

Family

50

false

This entry represents the type III secretion protein EspD. The pathogenesis of enteropathogenic Escherichia coli (EPEC) involves the translocation of effector proteins by the type III secretion system into the host cell, including translocated intimin receptor (Tir) and several E. coli secreted proteins (Esp). Secretio...

[]

0

[ "PIRSF" ]

[ "PIRSF033018" ]

[ "EspD" ]

[ 50 ]

1

[]

0

[]

0

[ "PUB00053423", "PUB00053424" ]

[ "12654835", "16548888" ]

[ "CesD2 of enteropathogenic Escherichia coli is a second chaperone for the type III secretion translocator protein EspD.", "Esp-independent functional integration of the translocated intimin receptor (Tir) of enteropathogenic Escherichia coli (EPEC) into host cell membranes." ]

[ 2003, 2006 ]

2

[]

0

null

[ "Enterobacteriaceae" ]

[ 50 ]

1

[]

0

true

Family

Type III secretion system, secreted protein EspD

T3SS_EspD

2

IPR014576

14,576

Predicted phosphoesterase, YhaO type

Pesterase_YhaO

Family

3,527

false

These proteins contain one copy of the calcineurin-like phosphoesterase domain ( ), followed by a carboxyl-terminal extension that is less well conserved. They possess motifs characteristic of a variety of enzymatically active phosphoesterases [ ], including acid and alkaline phosphatases, phosphoprotein phosphatases, ...

[]

0

[ "PIRSF" ]

[ "PIRSF033091" ]

[ "Pesterase_YhaO" ]

[ 3527 ]

1

[]

0

[]

0

[ "PUB00014394" ]

[ "8683579" ]

[ "Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Geodia barretti", "Methanomicrobia", "metagenomes" ]

[ 3474, 1, 33, 19 ]

4

[]

0

true

Family

Predicted phosphoesterase, YhaO type

Pesterase_YhaO

7

IPR014577

14,577

Uncharacterised conserved protein UCP033093, metallophosphoesterase-type

UCP033093_metalloPase

Family

1,779

false

These conserved bacterial proteins contain one copy of the calcineurin-like phosphoesterase domain ( ) and possess most of the motifs characteristic of a variety of enzymatically active phosphoesterases [ ], including acid and alkaline phosphatases, phosphoprotein phosphatases, 5'-nucleotidase, bis(5'-nucleosyl)-tetrap...

[]

0

[ "PIRSF" ]

[ "PIRSF033093" ]

[ "UCP_ML1119" ]

[ 1779 ]

1

[]

0

[]

0

[ "PUB00014394" ]

[ "8683579" ]

[ "Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Geodia barretti", "Methanobacterium", "unclassified sequences" ]

[ 1765, 1, 5, 8 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP033093, metallophosphoesterase-type

UCP033093_metalloPase

3

IPR014578

14,578

Predicted phosphoesterase, CT488 type

Pesterase_CT488

Family

1,310

false

This group of conserved proteins found in some bacteria contain one copy of the calcineurin-like phosphoesterase domain ( ) and possess motifs characteristic of a variety of enzymatically active phosphoesterases [ ], including acid and alkaline phosphatases, phosphoprotein phosphatases, 5'-nucleotidase, bis(5'-nucleosy...

[]

0

[ "PIRSF" ]

[ "PIRSF033094" ]

[ "Pesterase_CT488" ]

[ 1310 ]

1

[]

0

[]

0

[ "PUB00014394" ]

[ "8683579" ]

[ "Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Tritrichomonas foetus", "metagenomes" ]

[ 1292, 1, 17 ]

3

[]

0

true

Family

Predicted phosphoesterase, CT488 type

Pesterase_CT488

2

IPR014579

14,579

Predicted 5'-nucleotidase, SA0022 type

5NTD_SA0022

Family

84

false

This group represents a predicted 5'-nucleotidase, SA0022 type.

[]

0

[ "PIRSF" ]

[ "PIRSF033095" ]

[ "5NTD_SA0022" ]

[ 84 ]

1

[]

0

[]

0

[]

0

[ "IPR006179" ]

[]

1

0

1

[ "Bacilli" ]

[ 84 ]

1

[]

0

true

Family

Predicted 5'-nucleotidase, SA0022 type

5NTD_SA0022

6

IPR014580

14,580

Uncharacterised conserved protein UCP033199

UCP033199

Family

3,909

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09966", "PIRSF033199" ]

[ "DUF2200", "UCP033199" ]

[ 3909, 3426 ]

2

[]

0

[ "3c9p" ]

1

[]

0

[]

0

null

[ "Bacteria", "Haladaptatus pallidirubidus", "Symbiodiniaceae", "metagenomes" ]

[ 3855, 1, 8, 45 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP033199

UCP033199

1

IPR014582

14,582

Uncharacterised conserved protein UCP033535, periplasmic lipoprotein

UCP033535_lipo

Family

1,759

false

There is currently no experimental data for members of this group of predicted periplasmic lipoproteins or their homologues, nor do they exhibit features indicative of any function.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10054", "PIRSF033535" ]

[ "DUF2291", "UCP033535_plp" ]

[ 1759, 1298 ]

2

[]

0

[ "2f4i" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1748, 3, 8 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP033535, periplasmic lipoprotein

UCP033535_lipo

2

IPR014583

14,583

Uncharacterised protein family, Sir2-like

Uncharacterised_Sir2-like

Family

302

false

This group represents a predicted uncharacterised conserved protein with Sir2 domain.

[]

0

[ "PIRSF" ]

[ "PIRSF033541" ]

[ "ORF25P_Sir2" ]

[ 302 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 302 ]

1

[]

0

true

Family

Uncharacterised protein family, Sir2-like

Uncharacterised_Sir2-like

2

IPR014584

14,584

Uncharacterised conserved protein UCP033729

UCP033729

Family

222

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "NCBIFAM", "PIRSF" ]

[ "NF041287", "PIRSF033729" ]

[ "lipo_GerS_rel", "UCP033729" ]

[ 215, 168 ]

2

[]

0

[]

0

[ "PUB00106295" ]

[ "29950380" ]

[ "Clostridium difficile Lipoprotein GerS Is Required for Cortex Modification and Thus Spore Germination." ]

[ 2018 ]

1

[ "IPR060034" ]

[]

1

0

1

[ "Clostridia", "metagenomes" ]

[ 220, 2 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP033729

UCP033729

9

IPR014587

14,587

Uncharacterised conserved protein UCP034077

UCP034077

Family

1,084

false

This group represents a uncharacterised conserved proteins from enterobacteriaceae.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27683", "PIRSF034077" ]

[ "UCP034077", "UCP034077" ]

[ 1084, 281 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Opisthokonta", "Pseudomonadati", "ecological metagenomes" ]

[ 3, 1076, 5 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP034077

UCP034077

6

IPR014588

14,588

ATPase, Atu1862 type, predicted

ATPase_Atu1862_pred

Family

1,658

false

This group represents a predicted ATPase, Atu1862 type ( ).

[]

0

[ "PIRSF" ]

[ "PIRSF034081" ]

[ "ATPase_Atu1862" ]

[ 1658 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Alphaproteobacteria", "ecological metagenomes" ]

[ 1656, 2 ]

2

[]

0

true

Family

ATPase, Atu1862 type, predicted

ATPase_Atu1862_pred

8

IPR014590

14,590

Uncharacterised conserved protein MORN repeat-containing

UCP034300_MORN_rpt-cont

Family

450

false

This group represents a predicted uncharacterised protein with MORN repeat, SP2027 type.

[]

0

[ "PIRSF" ]

[ "PIRSF034300" ]

[ "UCP034300" ]

[ 450 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "human gut metagenome" ]

[ 449, 1 ]

2

[]

0

true

Family

Uncharacterised conserved protein MORN repeat-containing

UCP034300_MORN_rpt-cont

1

IPR014591

14,591

Uncharacterised conserved protein UCP034455

UCP034455

Family

311

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. However, they are predicted to be integral membrane proteins (with several transmembrane segments).

[]

0

[ "PIRSF" ]

[ "PIRSF034455" ]

[ "UCP034455" ]

[ 311 ]

1

[]

0

[]

0

[]

0

[ "IPR021125" ]

[]

1

0

1

[ "Bacteria", "Methanimicrococcus blatticola", "ecological metagenomes" ]

[ 308, 1, 2 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP034455

UCP034455

5

IPR014592

14,592

Predicted P-loop ATP-binding protein, VCA0200

P-loop_UCP034888

Family

1,448

false

There are currently no experimental data for members of this group or their homologues. However, they contain a P-loop motif and are, therefore, predicted to be ATP-binding proteins.

[]

0

[ "PIRSF" ]

[ "PIRSF034888" ]

[ "P-loop_UCP034888" ]

[ 1448 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Geodia barretti", "Siphoviridae sp. ctZd434", "metagenomes" ]

[ 42, 1382, 1, 1, 22 ]

5

[]

0

true

Family

Predicted P-loop ATP-binding protein, VCA0200

P-loop_UCP034888

4

IPR014596

14,596

Uncharacterised conserved protein UCP035836

UCP035836

Family

1,145

false

This group represents a predicted uncharacterised conserved protein.

[]

0

[ "PIRSF" ]

[ "PIRSF035836" ]

[ "UCP035836" ]

[ 1145 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1140, 5 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP035836

UCP035836

8

IPR014597

14,597

ABC transporter, periplasmic substrate-binding protein, predicted

ABC_tp_sb

Family

2,841

false

Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-bi...

[ "GO:0022857" ]

[ "transmembrane transporter activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF035859" ]

[ "ABC_tp_sb" ]

[ 2841 ]

1

[]

0

[]

0

[ "PUB00071925", "PUB00071938" ]

[ "18310026", "8003968" ]

[ "Characterization of a Pseudomonas putida ABC transporter (AatJMQP) required for acidic amino acid uptake: biochemical properties and regulation by the Aau two-component system.", "Sequence relationships between integral inner membrane proteins of binding protein-dependent transport systems: evolution by recurren...

[ 2008, 1994 ]

2

[ "IPR006059" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 2826, 2, 13 ]

3

[]

0

true

Family

ABC transporter, periplasmic substrate-binding protein, predicted

ABC_tp_sb

8

IPR014600

14,600

Uncharacterised conserved protein UCP035905, membrane protein

UCP035905_mem

Family

2,216

false

There is currently no experimental data for members of this group of predicted membrane proteins or their homologues, nor do they exhibit features indicative of any function.

[]

0

[ "PIRSF" ]

[ "PIRSF035905" ]

[ "UCP035905_mp" ]

[ 2216 ]

1

[]

0

[]

0

[]

0

[ "IPR019286" ]

[]

1

0

1

[ "Bacteria", "Effrenium voratum", "hydrothermal vent metagenome" ]

[ 2205, 1, 10 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP035905, membrane protein

UCP035905_mem

9

IPR014601

14,601

Transcriptional regulator with MarR-type HTH domain

Trans_reg_MarR_HTH

Family

1,495

false

There are currently no experimental data for members of this group. However, they contain an HTH DNA-binding domain related to the MarR superfamily of HTH domains.

[]

0

[ "PIRSF" ]

[ "PIRSF036158" ]

[ "UCP036158_MarR" ]

[ 1495 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "ecological metagenomes" ]

[ 1484, 11 ]

2

[]

0

true

Family

Transcriptional regulator with MarR-type HTH domain

Trans_reg_MarR_HTH

5

IPR014602

14,602

Uncharacterised conserved protein UCP036226

UCP036226

Family

435

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF036226" ]

[ "UCP036226" ]

[ 435 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "ecological metagenomes" ]

[ 432, 3 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP036226

UCP036226

3

IPR014605

14,605

Signal transduction response regulator PhyR-like, alphaproteobacteria

Sig_resp-reg_PhyR

Family

2,571

false

This entry represents signal transduction response regulators with a C-terminal receiver domain, such as PhyR, which is found in the Alphaproteobacterium Methylobacterium extorquens (Protomonas extorquens). PhyR is a key regulator for adaptation to epiphytic life (leaf colonising) of the bacterium, and is essential for...

[]

0

[ "NCBIFAM", "PIRSF" ]

[ "NF006623", "PIRSF036400" ]

[ "PRK09191.1", "RR_Ctr_UCP036400" ]

[ 2570, 2223 ]

2

[]

0

[ "3n0r", "4g97", "4qic", "5uxv", "5uxw", "9by5", "9cb6" ]

7

[ "PUB00042903", "PUB00042904", "PUB00159464", "PUB00159465" ]

[ "16926146", "18024517", "29052909", "26724735" ]

[ "A proteomic study of Methylobacterium extorquens reveals a response regulator essential for epiphytic growth.", "PhyR is involved in the general stress response of Methylobacterium extorquens AM1.", "Allosteric control of a bacterial stress response system by an anti-σ factor.", "Characterization of the gene...

[ 2006, 2008, 2018, 2016 ]

4

[]

0

null

[ "Effrenium voratum", "Pseudomonadota", "ecological metagenomes" ]

[ 1, 2562, 8 ]

3

[]

0

true

Family

Signal transduction response regulator PhyR-like, alphaproteobacteria

Sig_resp-reg_PhyR

9

IPR014606

14,606

D,D-heptose 7-phosphate kinase

Heptose_7-P_kinase

Family

1,890

false

This group of enzymes belongs to the GHMP kinase domain superfamily. GHMP kinases are a unique class of ATP-dependent enzymes (the abbreviation of which refers to the original members: galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase) [ ]. Enzymes belonging to this superfamily contain t...

[]

0

[ "PIRSF" ]

[ "PIRSF036406" ]

[ "Hept_kin" ]

[ 1890 ]

1

[ "EC", "METACYC" ]

[ "2.7.1.168", "PWY-6478" ]

[ "EC:2.7.1.168", "METACYC:PWY-6478" ]

2

[ "3k85", "4n3o", "4usk", "4usm", "4ut4", "4utg" ]

6

[ "PUB00003870", "PUB00015644", "PUB00015669", "PUB00015675", "PUB00015730", "PUB00015835", "PUB00015917", "PUB00015918", "PUB00015950", "PUB00016208" ]

[ "8577249", "11188689", "12771135", "8382990", "12001237", "12796487", "11373120", "15044388", "11751812", "11279237" ]

[ "Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11.", "Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily.", "Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate ...

[ 1995, 2000, 2003, 1993, 2002, 2003, 2001, 2004, 2002, 2001 ]

10

[ "IPR001174" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Caudoviricetes", "metagenomes" ]

[ 60, 1756, 6, 68 ]

4

[]

0

true

Family

D,D-heptose 7-phosphate kinase

Heptose_7-P_kinase

2

IPR014607

14,607

Alkane 1-monooxygenase, rubredoxin-type

Alk_mOase_rubredoxin-type

Family

89

false

This entry represents a family of alkane 1-monooxygenases that contain a rubredoxin domain.

[]

0

[ "PIRSF" ]

[ "PIRSF036487" ]

[ "Hydroxylase_rubr" ]

[ 89 ]

1

[]

0

[]

0

[]

0

[ "IPR033885" ]

[]

1

0

1

[ "Actinomycetes" ]

[ 89 ]

1

[]

0

true

Family

Alkane 1-monooxygenase, rubredoxin-type

Alk_mOase_rubredoxin-type

9

IPR014610

14,610

Globin, extracellular

Haemoglobin_extracell

Family

530

false

Globins are haem-containing proteins involved in binding and/or transporting oxygen. They belong to a very large and well studied family that is widely distributed in many organisms [ ]. Globins have evolved from a common ancestor and can be divided into three groups: single-domain globins, and two types of chimeric gl...

[ "GO:0005506", "GO:0019825", "GO:0020037", "GO:0015671", "GO:0005576", "GO:0005833" ]

[ "iron ion binding", "oxygen binding", "heme binding", "oxygen transport", "extracellular region", "hemoglobin complex" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

6

[ "PIRSF" ]

[ "PIRSF036517" ]

[ "Ext_hemo" ]

[ 530 ]

1

[]

0

[ "1x9f", "1yhu", "2d2m", "2d2n", "2gtl", "2zfo", "2zs0", "2zs1", "3wct", "3wcu", "3wcv", "3wcw", "4u8u", "4v93", "4wch", "5m3l", "7e96", "7e97", "7e98", "7e99", "7vlc", "7vld", "7vle", "7vlf" ]

24

[ "PUB00000422", "PUB00002385", "PUB00016016", "PUB00022057", "PUB00027839", "PUB00029465", "PUB00035865", "PUB00035866", "PUB00035867", "PUB00035868", "PUB00035869", "PUB00035870", "PUB00035871", "PUB00035872", "PUB00035873", "PUB00035877", "PUB00035882", "PUB00035887", "PUB000358...

[ "7599114", "6157691", "15096613", "12093902", "11294835", "12962627", "16600051", "17540514", "11092893", "11481493", "15598488", "16888280", "15598493", "15339940", "15804833", "17084861", "1445857", "17451435", "16766219", "17540516", "17701548", "17656582", "23209182",...

[ "The D-helix in myoglobin and in the beta subunit of hemoglobin is required for the retention of heme.", "Complete amino acid sequences of the major early embryonic alpha-like globins of the chicken.", "Ancestral hemoglobins in Archaea.", "The crystal structure of a tetrameric hemoglobin in a partial hemichro...

[ 1995, 1980, 2004, 2002, 2001, 2003, 2006, 2007, 2001, 2001, 2005, 2006, 2005, 2004, 2004, 2007, 1992, 2007, 2006, 2007, 2007, 2007, 2012, 2011 ]

24

[]

0

null

[ "Bilateria" ]

[ 530 ]

1

[]

0

true

Family

Globin, extracellular

Haemoglobin_extracell

7

IPR014612

14,612

Ribonucleases P/MRP protein subunit Rpp20/Pop7

Pop7/Rpp20

Family

2,646

false

This entry includes fission yeast ribonucleases P/MRP protein subunit Pop7 and its homologue, Rpp20, from animals. Pop7/Rpp20 is a component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. They are also a component of RNase MRP complex, which cleaves pre-rRNA sequenc...

[ "GO:0001682", "GO:0006396", "GO:0000172", "GO:0005655" ]

[ "tRNA 5'-leader removal", "RNA processing", "ribonuclease MRP complex", "nucleolar ribonuclease P complex" ]

[ "biological_process", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF12328", "PIRSF036572", "PTHR15314" ]

[ "Rpp20", "RPP20", "" ]

[ 2557, 576, 1258 ]

3

[ "REACTOME" ]

[ "R-HSA-6784531" ]

[ "REACTOME:R-HSA-6784531" ]

1

[ "3iab", "6agb", "6ah3", "6ahr", "6ahu", "6cwx", "6lt7", "6w6v", "7c79", "7c7a" ]

10

[ "PUB00027879", "PUB00076341" ]

[ "15096576", "21450806" ]

[ "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex.", "RNA binding properties of conserved protein subunits of human RNase P." ]

[ 2004, 2011 ]

2

[]

[ "IPR020241" ]

0

1

0

[ "Eukaryota" ]

[ 2646 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 1, 2, 2, 1, 1, 2, 1, 1 ]

9

true

Family

Ribonucleases P/MRP protein subunit Rpp20/Pop7

Pop7/Rpp20

8

IPR014614

14,614

KsdD-like steroid dehydrogenase

KsdD_DH

Family

5,391

false

This entry represents family of KsdD-like steroid dehydrogenases and related proteins [ ]. 3-Ketosteroid delta(1)-dehydrogenase catalyzes the 1(2)-dehydrogenation of 3-ketosteroid substrates using flavin adenine dinucleotide as a cofactor. The enzyme plays a crucial role in microbial steroid degradation, both under aer...

[ "GO:0016627" ]

[ "oxidoreductase activity, acting on the CH-CH group of donors" ]

[ "molecular_function" ]

1

[ "NCBIFAM", "PIRSF", "PANTHER" ]

[ "NF009472", "PIRSF036654", "PTHR43260" ]

[ "PRK12834.1", "UCP036654", "" ]

[ 5121, 5041, 5391 ]

3

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "1.3.99.-", "PWY-6061", "PWY-6279", "PWY-6672", "PWY-6944", "PWY-6945", "PWY-6946", "PWY-6948", "PWY-7552", "PWY-7636", "PWY-8151", "PWY-8152", "PWY-8155" ]

[ "EC:1.3.99.-", "METACYC:PWY-6061", "METACYC:PWY-6279", "METACYC:PWY-6672", "METACYC:PWY-6944", "METACYC:PWY-6945", "METACYC:PWY-6946", "METACYC:PWY-6948", "METACYC:PWY-7552", "METACYC:PWY-7636", "METACYC:PWY-8151", "METACYC:PWY-8152", "METACYC:PWY-8155" ]

13

[]

0

[ "PUB00104282" ]

[ "16000729" ]

[ "Identification and targeted disruption of the gene encoding the main 3-ketosteroid dehydrogenase in Mycobacterium smegmatis." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4875, 498, 18 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

KsdD-like steroid dehydrogenase

KsdD_DH

4

IPR014615

14,615

Extracellular sulfatase

Extracellular_sulfatase

Family

2,343

false

This group represents an extracellular sulphatase. Please see the following relevant references: [ , ].

[ "GO:0005509", "GO:0008484", "GO:0005783", "GO:0005794", "GO:0009986" ]

[ "calcium ion binding", "sulfuric ester hydrolase activity", "endoplasmic reticulum", "Golgi apparatus", "cell surface" ]

[ "molecular_function", "molecular_function", "cellular_component", "cellular_component", "cellular_component" ]

5

[ "PIRSF" ]

[ "PIRSF036665" ]

[ "Sulf1" ]

[ 2343 ]

1

[ "EC", "EC" ]

[ "3.1.6.1", "3.1.6.14" ]

[ "EC:3.1.6.1", "EC:3.1.6.14" ]

2

[]

0

[ "PUB00016794", "PUB00016801" ]

[ "11895481", "12368295" ]

[ "Identification of a novel nonlysosomal sulphatase expressed in the floor plate, choroid plexus and cartilage.", "Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans." ]

[ 2002, 2002 ]

2

[]

0

null

[ "Gnathostomata" ]

[ 2343 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 58, 3, 4, 10 ]

4

true

Family

Extracellular sulfatase

Extracellular_sulfatase

9

IPR014617

14,617

Predicted membrane protein, Bacillus YphA type

YphA_Bacsu

Family

968

false

This entry represents a family of proteins related to Bacillus subtilis YphA protein. These proteins are predicted as integral membrane proteins and are structurally related to which contains α-helices.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF24124", "PIRSF036710" ]

[ "YphA", "YphA_Bacsu" ]

[ 968, 596 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillales" ]

[ 968 ]

1

[]

0

true

Family

Predicted membrane protein, Bacillus YphA type

YphA_Bacsu

2

IPR014619

14,619

Deoxycytidylate hydroxymethylase

Deoxycytidylate_hydroxyMease

Family

165

false

In bacteriophage T4, a specific DNA modification system has evolved in order to protect its own DNA from degradation by host nucleases [ ]. Firstly, the cytosine base in dCMP is hydroxymethylated by the T4 enzyme deoxycytidylate hydroxymethylase to produce hydroxymethyl-dCMP (Hm-dCMP). This product is subsequently conv...

[ "GO:0047153" ]

[ "deoxycytidylate 5-hydroxymethyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF036750" ]

[ "dCMP_HMase" ]

[ 165 ]

1

[ "EC" ]

[ "2.1.2.8" ]

[ "EC:2.1.2.8" ]

1

[ "1b49", "1b5d", "1b5e", "6a9a", "6a9b", "6l18" ]

6

[ "PUB00023500", "PUB00034724", "PUB00034725", "PUB00034726" ]

[ "10064578", "7649402", "8434123", "1560001" ]

[ "Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex.", "Hypermodified bases in DNA.", "Enzyme organization in DNA precursor biosynthesis.", "Specific associations of T4 bacteriophage proteins with immobilized de...

[ 1999, 1995, 1993, 1992 ]

4

[]

0

null

[ "Viruses", "Xanthomarina gelatinilytica" ]

[ 164, 1 ]

2

[]

0

true

Family

Deoxycytidylate hydroxymethylase

Deoxycytidylate_hydroxyMease

5

IPR014620

14,620

Thymidylate synthase, archaea

Thymidylate_synthase_arc

Family

251

false

Thymidylate synthase catalyses the reductive methylation of dUMP to dTMP using methylene tetrahydrofolate as a methyl donor, an essential step in DNA biosynthesis [ ]. This entry represents a number of proteins that are predicted thymidylate synthases though their function has not been proven. The Methanobacterium ther...

[ "GO:0004799", "GO:0006235", "GO:0005737" ]

[ "thymidylate synthase activity", "dTTP biosynthetic process", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PIRSF", "NCBIFAM" ]

[ "MF_01686", "PIRSF036752", "TIGR03283" ]

[ "Thymidy_synth_arch", "TSase_MJ051", "thy_syn_methano" ]

[ 153, 244, 177 ]

3

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

146

[]

0

[ "PUB00016816", "PUB00034730" ]

[ "8143733", "17216455" ]

[ "Purification and partial characterization of a putative thymidylate synthase from Methanobacterium thermoautotrophicum.", "Thymidyl biosynthesis enzymes as antibiotic targets." ]

[ 1994, 2007 ]

2

[ "IPR045097" ]

[]

1

0

1

[ "Archaea", "Bacteria", "ecological metagenomes", "unclassified Caudoviricetes" ]

[ 216, 24, 9, 2 ]

4

[]

0

true

Family

Thymidylate synthase, archaea

Thymidylate_synthase_arc

8

IPR014621

14,621

Uncharacterised conserved protein UCP036778, sugar epimerase-type

UCP036778_sugar_epimerase

Family

1,423

false

This entry represents a related group of proteins found in some proteobacteria. They have not been experimentally characterised but are predicted to contain a TIM barrel xylose isomerase-like domain and may function as sugar epimerases or isomerases. From their genomic contexts some may perform a similar function to Io...

[]

0

[ "PIRSF" ]

[ "PIRSF036778" ]

[ "UCP036778" ]

[ 1423 ]

1

[]

0

[ "2q02", "4hgx" ]

2

[ "PUB00028654" ]

[ "12112707" ]

[ "Crystal structure of Bacillus subtilis ioli shows endonuclase IV fold with altered Zn binding." ]

[ 2002 ]

1

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1421, 2 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP036778, sugar epimerase-type

UCP036778_sugar_epimerase

7

IPR014622

14,622

Uncharacterised conserved protein UCP036794, erythromycin esterase-type

UCP036794_erythomycin

Family

4,457

false

This group represents an uncharacterised conserved protein with an erythromycin esterase domain.

[]

0

[ "PIRSF" ]

[ "PIRSF036794" ]

[ "UCP_erythr_ester" ]

[ 4457 ]

1

[]

0

[ "2qgm", "2rad", "3b55" ]

3

[]

0

[ "IPR007815" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 42, 3830, 570, 15 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Uncharacterised conserved protein UCP036794, erythromycin esterase-type

UCP036794_erythomycin

3

IPR014624

14,624

Predicted 26S proteasome regulatory complex, non-ATPase subcomplex, subunit s5a, Plasmodium

26S_protsm_s5a

Family

32

false

This group represents a predicted 26S proteasome regulatory complex, non-ATPase subcomplex, subunit s5a, Plasmodium type. Please see the following relevant reference: [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF036805" ]

[ "26S_protsm_s5a" ]

[ 32 ]

1

[]

0

[]

0

[ "PUB00016866" ]

[ "15571806" ]

[ "The proteasome: a proteolytic nanomachine of cell regulation and waste disposal." ]

[ 2004 ]

1

[ "IPR027040" ]

[]

1

0

1

[ "Plasmodium" ]

[ 32 ]

1

[]

0

true

Family

Predicted 26S proteasome regulatory complex, non-ATPase subcomplex, subunit s5a, Plasmodium

26S_protsm_s5a

3

IPR014625

14,625

Filoviruses glycoprotein

GPC_FiloV

Family

685

false

Proteins in this family include the envelope glycoprotein and the pre-small/secreted glycoprotein from Filoviridae [ ]. The envelope glycoprotein can be cleaved into 3 chains: GP1, GP2 and GP2-delta. GP1 is responsible for binding to the receptor(s), such as CD209 and CLEC4M, on target cells. These interactions not onl...

[]

0

[ "PIRSF" ]

[ "PIRSF036874" ]

[ "GPC_FiloV" ]

[ 685 ]

1

[]

0

[ "5kel", "6vkm", "7kew", "7kfe", "9bsu", "9bsv", "9nnu" ]

7

[ "PUB00027896", "PUB00052490", "PUB00063817", "PUB00063818", "PUB00063819", "PUB00063820", "PUB00063821" ]

[ "8437211", "17005688", "16775318", "11152533", "12482654", "16051836", "15681442" ]

[ "Marburg virus gene 4 encodes the virion membrane protein, a type I transmembrane glycoprotein.", "Tyro3 family-mediated cell entry of Ebola and Marburg viruses.", "The signal peptide of the ebolavirus glycoprotein influences interaction with the cellular lectins DC-SIGN and DC-SIGNR.", "Ebola virus glycoprot...

[ 1993, 2006, 2006, 2001, 2002, 2005, 2005 ]

7

[]

0

null

[ "Filoviridae" ]

[ 685 ]

1

[]

0

true

Family

Filoviruses glycoprotein

GPC_FiloV

1

IPR014626

14,626

Signal transduction response regulator with modified HD-GYP domain, putative

Sig_transdc_resp-reg_put

Family

679

false

This entry represents a group of signal transduction response regulators which contain a modified version of the HD-GYP domain as an output domain. Response regulators of the microbial two-component signal transduction systems typically consist of an N-terminal CheY-like receiver (phosphoacceptor) domain and a C-termin...

[]

0

[ "PIRSF" ]

[ "PIRSF036883" ]

[ "RR_HD-GYP_mod" ]

[ 679 ]

1

[]

0

[]

0

[ "PUB00005837", "PUB00007150", "PUB00007866", "PUB00011096", "PUB00011157", "PUB00011190", "PUB00011195", "PUB00011196" ]

[ "9868367", "11557134", "11406410", "10966457", "10622255", "10500846", "11123673", "10943560" ]

[ "The HD domain defines a new superfamily of metal-dependent phosphohydrolases.", "Novel domains of the prokaryotic two-component signal transduction systems.", "Histidine kinases and response regulator proteins in two-component signaling systems.", "Two-component signal transduction.", "Structure of a trans...

[ 1998, 2001, 2001, 2000, 1999, 1999, 2000, 1999 ]

8

[]

0

null

[ "Bacteria", "Knufia peltigerae", "ecological metagenomes" ]

[ 672, 1, 6 ]

3

[]

0

true

Family

Signal transduction response regulator with modified HD-GYP domain, putative

Sig_transdc_resp-reg_put

2

IPR014627

14,627

Uncharacterised conserved protein UCP036888, signal transduction HD-GYP-like, PA5346 type

UCP036888_HDGYP-like

Family

1,146

false

Members of this group contain a modified version of the HD-GYP domain and an uncharacterised N-terminal domain. There is currently no experimental data for members of this group. HD-GYP is a conserved domain found in response regulator modules of various signal transduction systems. The involvement of the HD-GYP domain...

[]

0

[ "PIRSF" ]

[ "PIRSF036888" ]

[ "HDGYPm_UCP036888" ]

[ 1146 ]

1

[]

0

[ "3mem", "9qzk" ]

2

[ "PUB00005837", "PUB00007150", "PUB00011195", "PUB00011196" ]

[ "9868367", "11557134", "11123673", "10943560" ]

[ "The HD domain defines a new superfamily of metal-dependent phosphohydrolases.", "Novel domains of the prokaryotic two-component signal transduction systems.", "A two-component system involving an HD-GYP domain protein links cell-cell signalling to pathogenicity gene expression in Xanthomonas campestris.", "A...

[ 1998, 2001, 2000, 1999 ]

4

[]

0

null

[ "Pseudomonadota", "Pseudomonas phage YMC12/01/R24", "ecological metagenomes" ]

[ 1130, 1, 15 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP036888, signal transduction HD-GYP-like, PA5346 type

UCP036888_HDGYP-like

8

IPR014628

14,628

Mannose-6-phosphate isomerase, Firmicutes type, short form

Man6P_isomerase_Firm_short

Family

6,746

false

Mannose-6-phosphate isomerase or phosphomannose isomerase ( ) (PMI) is the enzyme that catalyses the interconversion of mannose-6-phosphate and fructose-6-phosphate. In eukaryotes PMI is involved in the synthesis of GDP-mannose, a constituent of N-and O-linked glycans and GPI anchors and in prokaryotes it participates ...

[ "GO:0004476", "GO:0005975" ]

[ "mannose-6-phosphate isomerase activity", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF036894" ]

[ "PMI_Firm_short" ]

[ 6746 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "5.3.1.8", "PWY-3861", "PWY-3881", "PWY-5659", "PWY-6992", "PWY-7456", "PWY-7586" ]

[ "EC:5.3.1.8", "METACYC:PWY-3861", "METACYC:PWY-3881", "METACYC:PWY-5659", "METACYC:PWY-6992", "METACYC:PWY-7456", "METACYC:PWY-7586" ]

7

[ "1qwr", "1zx5" ]

2

[ "PUB00001448", "PUB00007419" ]

[ "8307007", "11165500" ]

[ "Purification, cDNA cloning and heterologous expression of human phosphomannose isomerase.", "JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta." ]

[ 1994, 2001 ]

2

[ "IPR001250" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Pithovirus LCPAC404", "metagenomes" ]

[ 6678, 11, 7, 1, 49 ]

5

[]

0

true

Family

Mannose-6-phosphate isomerase, Firmicutes type, short form

Man6P_isomerase_Firm_short

6

IPR014631

14,631

Cellular repressor of E1A-stimulated genes (CREG)

CREG

Family

1,449

false

CREG (cellular repressor of E1A-stimulated genes) is a secreted glycoprotein that inhibits cell growth in different cell types. CREG binds M6P(mannose-6-phosphate)/IGF2R(insulin-like growth factor II receptor) and mediates cell growth and is involved in cell differentiation in the nervous system. Although the CREG prot...

[]

0

[ "PIRSF" ]

[ "PIRSF036911" ]

[ "CREG" ]

[ 1449 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-6798695", "R-HSA-6798695", "R-MMU-6798695" ]

[ "REACTOME:R-GGA-6798695", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-6798695" ]

3

[ "1xhn" ]

1

[ "PUB00027886", "PUB00027933" ]

[ "12934103", "12408961" ]

[ "The secreted glycoprotein CREG inhibits cell growth dependent on the mannose-6-phosphate/insulin-like growth factor II receptor.", "Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain." ]

[ 2003, 2002 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1449 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]

[ 6, 2, 2, 4, 4, 2, 3 ]

7

true

Family

Cellular repressor of E1A-stimulated genes (CREG)

CREG

6

IPR014635

14,635

Alpha-amylase, MalS type

A_amylase_MalS

Family

1,740

false

Alpha-amylase is classified as family 13 ( ) of the glycosyl hydrolases and is present in archaea, bacteria, fungi, plants and animals. Alpha-amylase is an essential enzyme in alpha-glucan metabolism, acting to catalyse the hydrolysis of alpha-1,4-glucosidic bonds of glycogen, starch and related polysaccharides. Althou...

[ "GO:0004556", "GO:0005509", "GO:0009313", "GO:0030980", "GO:0042597" ]

[ "alpha-amylase activity", "calcium ion binding", "oligosaccharide catabolic process", "alpha-glucan catabolic process", "periplasmic space" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process", "cellular_component" ]

5

[ "PIRSF" ]

[ "PIRSF036917" ]

[ "Alph_amls_MalS" ]

[ 1740 ]

1

[]

0

[ "8im8", "9us3", "9us4", "9us6" ]

4

[ "PUB00027666", "PUB00027828" ]

[ "11141191", "9268356" ]

[ "Evolution of alpha-amylases: architectural features and key residues in the stabilization of the (beta/alpha)(8) scaffold.", "Biochemical characterization and mass spectrometric disulfide bond mapping of periplasmic alpha-amylase MalS of Escherichia coli." ]

[ 2001, 1997 ]

2

[]

0

null

[ "Bacteria" ]

[ 1740 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Alpha-amylase, MalS type

A_amylase_MalS

8

IPR014636

14,636

RNase H, phosphoglycerate mutase domain-containing

RNaseH/PGlycerate_mutase

Family

2,768

false

These proteins contain an RNase H domain ( ) followed by a phosphoglycerate mutase family domain ( ). The protein from Corynebacterium glutamicum appears to be a functional RNase H [ ] ( ). Protein Rv2228c is the only known endonuclease from Mycobacterium tuberculosis with RNase H activity, catalysing the hydrolysis of...

[]

0

[ "NCBIFAM", "PIRSF" ]

[ "NF005567", "PIRSF036922" ]

[ "PRK07238.1", "RNaseH_PGAM" ]

[ 2729, 2401 ]

2

[]

0

[]

0

[ "PUB00027992", "PUB00085168" ]

[ "14646202", "20363939" ]

[ "A Corynebacterium glutamicum rnhA recG double mutant showing lysozyme-sensitivity, temperature-sensitive growth, and UV-sensitivity.", "Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis." ]

[ 2003, 2010 ]

2

[ "IPR013078" ]

[]

1

0

1

[ "Actinomycetes", "metagenomes" ]

[ 2695, 73 ]

2

[]

0

true

Family

RNase H, phosphoglycerate mutase domain-containing

RNaseH/PGlycerate_mutase

7

IPR014637

14,637

Sorting nexin-5/6/32

SNX5/SNX6/SNX32

Family

2,943

false

Sorting nexins (SNXs) are a diverse group of cellular trafficking proteins that are unified by the presence of a phospholipid-binding motif, the PX domain. The ability of these proteins to bind specific phospholipids, as well as their propensity to form protein-protein complexes, points to a role for these proteins in ...

[]

0

[ "PIRSF" ]

[ "PIRSF036924" ]

[ "Snx5_Snx6" ]

[ 2943 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-432722", "R-HSA-432722", "R-MMU-432722", "R-RNO-432722" ]

[ "REACTOME:R-BTA-432722", "REACTOME:R-HSA-432722", "REACTOME:R-MMU-432722", "REACTOME:R-RNO-432722" ]

4

[ "8afz" ]

1

[ "PUB00010010", "PUB00014978", "PUB00027894", "PUB00027993", "PUB00068947", "PUB00068948" ]

[ "12461558", "14993925", "11591366", "11279102", "18854019", "21048941" ]

[ "Sorting out the cellular functions of sorting nexins.", "The BAR-domain family of proteins: a case of bending and binding?", "Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus.", "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of r...

[ 2002, 2004, 2001, 2001, 2008, 2010 ]

6

[]

0

null

[ "Metazoa" ]

[ 2943 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 8, 6, 9 ]

6

true

Family

Sorting nexin-5/6/32

SNX5/SNX6/SNX32

6

IPR014640

14,640

Imidazole glycerol phosphate synthase HisHF

IGPS_HisHF

Family

2,271

false

Members of this group are eukaryotic bifunctional enzymes with glutamine amidotransferase ( ) and cyclase activities ( ) that catalyse the fifth and sixth steps of the histidine biosynthetic pathway. In eubacteria, these steps are catalysed by a complex formed by two subunits, namely the glutamine amidotransferase HisH...

[ "GO:0000107", "GO:0004359", "GO:0000105" ]

[ "imidazoleglycerol-phosphate synthase activity", "glutaminase activity", "L-histidine biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF036936" ]

[ "IGPS_HisHF" ]

[ 2271 ]

1

[ "EC", "EC", "METACYC" ]

[ "3.5.1.2", "4.3.2.10", "PWY-5921" ]

[ "EC:3.5.1.2", "EC:4.3.2.10", "METACYC:PWY-5921" ]

3

[ "1jvn", "1ox4", "1ox5", "1ox6" ]

4

[ "PUB00017573", "PUB00017574", "PUB00027820", "PUB00027875" ]

[ "9654139", "8366040", "8852895", "11277623" ]

[ "An Arabidopsis cDNA encoding a bifunctional glutamine amidotransferase/cyclase suppresses the histidine auxotrophy of a Saccharomyces cerevisiae his7 mutant.", "Cloning, primary structure, and regulation of the HIS7 gene encoding a bifunctional glutamine amidotransferase: cyclase from Saccharomyces cerevisiae.",...

[ 1998, 1993, 1996, 2001 ]

4

[]

0

null

[ "Eukaryota", "Pseudomonadati", "hydrothermal vent metagenome" ]

[ 2164, 106, 1 ]

3

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 3, 1, 2, 1, 1, 3 ]

6

true

Family

Imidazole glycerol phosphate synthase HisHF

IGPS_HisHF

2

IPR014644

14,644

Protein arginine N-methyltransferase PRMT7

MeTrfase_PRMT7

Family

1,834

false

This entry represents protein arginine N-methyltransferase PRMT7 [ ]. PRMT7 can catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. It mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleopr...

[ "GO:0008168", "GO:0006479" ]

[ "methyltransferase activity", "protein methylation" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF036946" ]

[ "Arg_N-mtase" ]

[ 1834 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

150

[ "3wst", "3x0d", "4c4a", "6ogn" ]

4

[ "PUB00058102", "PUB00058185", "PUB00058186", "PUB00058187" ]

[ "15044439", "15494416", "17709427", "19110445" ]

[ "PRMT7 is a member of the protein arginine methyltransferase family with a distinct substrate specificity.", "PRMT7, a new protein arginine methyltransferase that synthesizes symmetric dimethylarginine.", "Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins.", "...

[ 2004, 2005, 2007, 2009 ]

4

[ "IPR025799" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1834 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]

[ 5, 1, 1, 1, 8, 1, 1, 3 ]

8

true

Family

Protein arginine N-methyltransferase PRMT7

MeTrfase_PRMT7

7

IPR014645

14,645

Target of Myb protein 1

TOM1

Family

6,160

false

Tom1 (target of Myb 1) and its related proteins (Tom1L1 and Tom1L2) constitute a protein family and share an N-terminal VHS (Vps27p/Hrs/Stam) domain followed by a GAT (GGA and Tom1) domain. VHS domains are found at the N termini of select proteins involved in intracellular membrane trafficking and are often localized t...

[]

0

[ "PIRSF" ]

[ "PIRSF036948" ]

[ "TOM1" ]

[ 6160 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-6798695", "R-HSA-6798695", "R-MMU-6798695" ]

[ "REACTOME:R-GGA-6798695", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-6798695" ]

3

[]

0

[ "PUB00008037", "PUB00027927", "PUB00027951", "PUB00027977" ]

[ "10985773", "15611048", "14563850", "15056867" ]

[ "Structure of the VHS domain of human Tom1 (target of myb 1): insights into interactions with proteins and membranes.", "Interactions of TOM1L1 with the multivesicular body sorting machinery.", "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin.", "Tom1 (target of Myb 1) is...

[ 2000, 2005, 2003, 2004 ]

4

[]

0

null

[ "Eukaryota" ]

[ 6160 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 11, 2, 10, 3, 15, 9, 6, 15, 7 ]

9

true

Family

Target of Myb protein 1

TOM1

3

IPR014646

14,646

Replication factor A protein 2

Rfa2/RPA32

Family

3,871

false

Rfa2 (also known as RPA32) is a component of the replication protein A (RPA) complex, which binds to and removes secondary structure from ssDNA. The RPA complex is involved in DNA replication, repair, and recombination [ ].

[ "GO:0003677", "GO:0006260", "GO:0006281", "GO:0006310", "GO:0005634" ]

[ "DNA binding", "DNA replication", "DNA repair", "DNA recombination", "nucleus" ]

[ "molecular_function", "biological_process", "biological_process", "biological_process", "cellular_component" ]

5

[ "PIRSF" ]

[ "PIRSF036949" ]

[ "RPA32" ]

[ 3871 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-110312", "R-HSA-110314", "R-HSA-110320", "R-HSA-174437", "R-HSA-176187", "R-HSA-3371453", "R-HSA-3371511", "R-HSA-5358565", "R-HSA-5358606", "R-HSA-5651801", "R-HSA-5655862", "R-HSA-5656121", "R-HSA-5656169", "R-HSA-5685938", "R-HSA-5685942", "R-HSA-5693607", "R-HSA-5693616", ...

[ "REACTOME:R-HSA-110312", "REACTOME:R-HSA-110314", "REACTOME:R-HSA-110320", "REACTOME:R-HSA-174437", "REACTOME:R-HSA-176187", "REACTOME:R-HSA-3371453", "REACTOME:R-HSA-3371511", "REACTOME:R-HSA-5358565", "REACTOME:R-HSA-5358606", "REACTOME:R-HSA-5651801", "REACTOME:R-HSA-5655862", "REACTOME:R-H...

126

[ "2pi2", "2z6k", "8rk2", "9mj5" ]

4

[ "PUB00070983" ]

[ "20012581" ]

[ "Eukaryotic single-stranded DNA binding proteins: central factors in genome stability." ]

[ 2010 ]

1

[ "IPR040260" ]

[]

1

0

1

[ "Eukaryota" ]

[ 3871 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 6, 4, 2, 1, 3, 3, 1, 1, 12 ]

12

true

Family

Replication factor A protein 2

Rfa2/RPA32

9

IPR014647

14,647

CST complex subunit Stn1

Stn1

Family

1,064

false

Stn1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to t...

[ "GO:0043047", "GO:0016233", "GO:1990879" ]

[ "single-stranded telomeric DNA binding", "telomere capping", "CST complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF036950" ]

[ "UCP036950" ]

[ 1064 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-174411", "R-BTA-174430", "R-HSA-174411", "R-HSA-174430", "R-MMU-174411", "R-MMU-174430", "R-RNO-174411", "R-RNO-174430" ]

[ "REACTOME:R-BTA-174411", "REACTOME:R-BTA-174430", "REACTOME:R-HSA-174411", "REACTOME:R-HSA-174430", "REACTOME:R-MMU-174411", "REACTOME:R-MMU-174430", "REACTOME:R-RNO-174411", "REACTOME:R-RNO-174430" ]

8

[ "6w6w", "7u5c", "8d0b", "8d0k", "8sok" ]

5

[ "PUB00053884", "PUB00053885", "PUB00153024" ]

[ "19854130", "19648609", "25483097" ]

[ "RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway.", "OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation.", "Human CST abundance determines recove...

[ 2009, 2009, 2014 ]

3

[ "IPR040260" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1064 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 7, 2, 6 ]

4

true

Family

CST complex subunit Stn1

Stn1

6

IPR014648

14,648

Neuropilin

Family

3,923

false

Neuropilins are essential multifunctional vertebrate cell surface receptors [ ]. They function as receptors for axon guidance factor semaphorin class 3 (Sema3), vascular endothelial growth factor (VEGF) and placenta growth factor-2 (PLGF-2).

[ "GO:0005021", "GO:0017154", "GO:0001525", "GO:0007411", "GO:0038084" ]

[ "vascular endothelial growth factor receptor activity", "semaphorin receptor activity", "angiogenesis", "axon guidance", "vascular endothelial growth factor signaling pathway" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process", "biological_process" ]

5

[ "PIRSF" ]

[ "PIRSF036960" ]

[ "Neuropilin" ]

[ 3923 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DRE-194306", "R-DRE-399954", "R-DRE-399956", "R-HSA-194306", "R-HSA-376176", "R-HSA-399954", "R-HSA-399955", "R-HSA-399956", "R-HSA-445144", "R-HSA-447038", "R-HSA-447041", "R-HSA-9694614", "R-MMU-194306", "R-MMU-399954", "R-MMU-399955", "R-MMU-399956", "R-MMU-445144", "R-RNO-19...

[ "REACTOME:R-DRE-194306", "REACTOME:R-DRE-399954", "REACTOME:R-DRE-399956", "REACTOME:R-HSA-194306", "REACTOME:R-HSA-376176", "REACTOME:R-HSA-399954", "REACTOME:R-HSA-399955", "REACTOME:R-HSA-399956", "REACTOME:R-HSA-445144", "REACTOME:R-HSA-447038", "REACTOME:R-HSA-447041", "REACTOME:R-HSA-969...

22

[ "7t4s" ]

1

[ "PUB00063037" ]

[ "23116416" ]

[ "Function of the Neuropilin Family as Essential Pleiotropic Cell Surface Receptors." ]

[ 2012 ]

1

[]

0

null

[ "Gnathostomata" ]

[ 3923 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 29, 14, 6, 11 ]

4

true

Family

Neuropilin

7

IPR014651

14,651

Uncharacterised conserved protein, 2xCBS, MJ1404 type

UCP036983_2CBS_MJ1404

Family

497

false

This group represents an uncharacterised protein with 2 CBS domain pairs, MJ1404 type.

[]

0

[ "PIRSF" ]

[ "PIRSF036983" ]

[ "UCP_2CBS_MJ1404" ]

[ 497 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea" ]

[ 497 ]

1

[]

0

true

Family

Uncharacterised conserved protein, 2xCBS, MJ1404 type

UCP036983_2CBS_MJ1404

5

IPR014705

14,705

Synaptotagmin-17, C2B domain

Syt17_C2B

Domain

701

false

Synaptotagmin-17 (SYT17) belongs to the synaptotagmin family, which is a group of membrane-trafficking proteins that contain two C-terminal C2 domains. Although synaptotagmins have been found to have a unique N-terminal domain that is involved in membrane anchoring (e.g., synaptotagmin) or specific ligand binding (e.g....

[]

0

[ "CDD" ]

[ "cd08410" ]

[ "C2B_Synaptotagmin-17" ]

[ 701 ]

1

[]

0

[]

0

[ "PUB00024302", "PUB00026639", "PUB00027900", "PUB00027991", "PUB00035009" ]

[ "10545502", "11754837", "11716773", "8549819", "7791877" ]

[ "Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction.", "Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine.", "The N-terminal cysteine cluster is essential for membra...

[ 1999, 2001, 2001, 1996, 1995 ]

5

[ "IPR000008" ]

[]

1

0

1

[ "Bilateria" ]

[ 701 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 5, 3, 8 ]

4

true

Domain

Synaptotagmin-17, C2B domain

Syt17_C2B

9

IPR014709

14,709

Glutathione synthase, C-terminal, eukaryotic

Glutathione_synthase_C_euk

Homologous_superfamily

6,173

false

This superfamily represents the C-terminal domain found in eukaryotic glutathione synthetase ( ) (GSS), a homodimeric enzyme that catalyses the conversion of gamma-L-glutamyl-L-cysteine and glycine to phosphate and glutathione in the presence of ATP. This is the second step in glutathione biosynthesis, the first step b...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:3.30.1490.50" ]

[ "" ]

[ 6173 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "6.3.2.3", "PWY-8043", "R-DDI-174403", "R-HSA-174403", "R-HSA-5579006", "R-MMU-174403", "R-RNO-174403", "R-SCE-174403", "R-SPO-174403" ]

[ "EC:6.3.2.3", "METACYC:PWY-8043", "REACTOME:R-DDI-174403", "REACTOME:R-HSA-174403", "REACTOME:R-HSA-5579006", "REACTOME:R-MMU-174403", "REACTOME:R-RNO-174403", "REACTOME:R-SCE-174403", "REACTOME:R-SPO-174403" ]

9

[ "1m0t", "1m0w", "2hgs", "3kaj", "3kak", "3kal", "5oes", "5oet", "5oeu", "5oev", "8fbz" ]

11

[ "PUB00035960" ]

[ "15981742" ]

[ "Physiological and pathological aspects of GSH metabolism." ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 252, 5915, 6 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 2, 4, 7, 6, 2, 14, 6, 1, 1, 18 ]

12

true

Homologous_superfamily

Glutathione synthase, C-terminal, eukaryotic

Glutathione_synthase_C_euk

4

IPR014710

14,710

RmlC-like jelly roll fold

RmlC-like_jellyroll

Homologous_superfamily

849,926

false

RmlC (deoxythymidine diphosphates-4-dehydrorhamnose 3,5-epimerase; ) is a mainly beta class protein with a jelly roll-like topology. It is a dTDP-sugar isomerase enzyme involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria [ ]. This entry represents the domain with...

[]

0

[ "CATHGENE3D" ]

[ "G3DSA:2.60.120.10" ]

[ "" ]

[ 849926 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1237112", "R-BTA-1296072", "R-BTA-163615", "R-BTA-164378", "R-BTA-180024", "R-BTA-2485179", "R-BTA-2514859", "R-BTA-392517", "R-BTA-418457", "R-BTA-432040", "R-BTA-442720", "R-BTA-446205", "R-BTA-5610787", "R-BTA-5673001", "R-BTA-9634597", "R-BTA-983231", "R-BTA-9856530", "R...

[ "REACTOME:R-BTA-1237112", "REACTOME:R-BTA-1296072", "REACTOME:R-BTA-163615", "REACTOME:R-BTA-164378", "REACTOME:R-BTA-180024", "REACTOME:R-BTA-2485179", "REACTOME:R-BTA-2514859", "REACTOME:R-BTA-392517", "REACTOME:R-BTA-418457", "REACTOME:R-BTA-432040", "REACTOME:R-BTA-442720", "REACTOME:R-BTA...

250

[ "1cau", "1cav", "1caw", "1cax", "1cgp", "1cx4", "1dgr", "1dgw", "1dzr", "1dzt", "1ep0", "1epz", "1ey2", "1eyb", "1fi2", "1ft9", "1fxz", "1g6n", "1gqg", "1gqh", "1h1i", "1h1m", "1h2k", "1h2l", "1h2m", "1h2n", "1hw5", "1i5z", "1i6x", "1ipj", "1ipk", "1iz3"...

1,248

[ "PUB00003929", "PUB00009903", "PUB00009949", "PUB00014173", "PUB00014174", "PUB00014175", "PUB00014176", "PUB00014177", "PUB00017876", "PUB00034471", "PUB00034472" ]

[ "8612079", "10876237", "10802738", "11062559", "12065401", "11124907", "12402029", "11839311", "11017196", "10196160", "16500960" ]

[ "The x-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 angstrom resolution.", "Crystal structure of human homogentisate dioxygenase.", "RmlC, the third enzyme of dTDP-L-rhamnose pathway, is a new class of epimerase.", "Germin is a manganese containing homohexamer with oxalate ox...

[ 1996, 2000, 2000, 2000, 2002, 2001, 2002, 2002, 2000, 1999, 2006 ]

11

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "plasmids", "unclassified sequences" ]

[ 7490, 605478, 228726, 260, 2, 7970 ]

6

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 505, 45, 321, 94, 35, 194, 148, 20, 342, 214, 8, 6, 686 ]

13

true

Homologous_superfamily

RmlC-like jelly roll fold

RmlC-like_jellyroll

4