LiteFold/InterPro · Datasets at Hugging Face

IPR016427

16,427

Uncharacterised conserved protein UCP004699, CBS/ParB-like

UCP004699_CBS/ParB

Family

473

false

This group represents an uncharacterised protein with CBS and ParB-like domains.

[]

0

[ "PIRSF" ]

[ "PIRSF004699" ]

[ "UCP004699_CBS_ParB" ]

[ 473 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota", "ecological metagenomes" ]

[ 471, 2 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP004699, CBS/ParB-like

UCP004699_CBS/ParB

9

IPR016428

16,428

NADPH-dependent 7-cyano-7-deazaguanine reductase, QueF type 2

QueF_type2

Family

6,137

false

This group represents QueF-like proteins, closely related to (QueF/YkvM) but containing an additional N-terminal domain. They are predicted to function as NADPH-dependent nitrile oxidoreductase based on sequence similarity to , and to catalyse the NADPH-dependent reduction of 7-cyano-7-deazaguanineto7-aminomethyl-7-dea...

[ "GO:0046857", "GO:0008616", "GO:0005737" ]

[ "oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor", "tRNA queuosine(34) biosynthetic process", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PIRSF", "NCBIFAM" ]

[ "MF_00817", "PIRSF004750", "TIGR03138" ]

[ "QueF_type2", "Nitrile_oxidored_YqcD_prd", "QueF" ]

[ 5974, 6077, 6122 ]

3

[ "EC", "GP", "GP", "METACYC" ]

[ "1.7.1.13", "GenProp0677", "GenProp1400", "PWY-6700" ]

[ "EC:1.7.1.13", "GP:GenProp0677", "GP:GenProp1400", "METACYC:PWY-6700" ]

4

[ "3bp1", "3rj4", "3rzp", "3s19", "3uxj", "3uxv", "4ghm", "4iqi" ]

8

[ "PUB00035931", "PUB00035932", "PUB00035933" ]

[ "7063869", "14660578", "15767583" ]

[ "Queuine, a modified base incorporated posttranscriptionally into eukaryotic transfer RNA: wide distribution in nature.", "Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine.", "From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common f...

[ 1982, 2004, 2005 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Schizotequatrovirus", "metagenomes" ]

[ 6098, 7, 7, 25 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

NADPH-dependent 7-cyano-7-deazaguanine reductase, QueF type 2

QueF_type2

7

IPR016429

16,429

NAD biosynthesis/regulator protein NadR

NAD_NadR

Family

1,895

false

NadR functions as a transcriptional regulator in Salmonella enterica [ ]. When NAD+ is available, NadR is bound with its corepressor, NAD+, and this leads to DNA binding activity that acts as a repressor for several genes needed for de novo NAD+ biosynthesis [ , ]. NadR also possesses both NMN adenylyltransferase (NMNA...

[ "GO:0000309", "GO:0050262", "GO:0009435" ]

[ "nicotinamide-nucleotide adenylyltransferase activity", "ribosylnicotinamide kinase activity", "NAD+ biosynthetic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF004776" ]

[ "NadR_NMNAT/RNK" ]

[ 1895 ]

1

[ "EC", "EC" ]

[ "2.7.1.22", "2.7.7.1" ]

[ "EC:2.7.1.22", "EC:2.7.7.1" ]

2

[ "1lw7", "6gye", "6gyf", "6gzo", "8x7f" ]

5

[ "PUB00008725", "PUB00091762", "PUB00092573", "PUB00092574", "PUB00092575" ]

[ "2198247", "15805524", "3039308", "9882682", "15968050" ]

[ "Regulation of NAD metabolism in Salmonella typhimurium: molecular sequence analysis of the bifunctional nadR regulator and the nadA-pnuC operon.", "Regulation of NAD synthesis by the trifunctional NadR protein of Salmonella enterica.", "Regulation of NAD metabolism in Salmonella typhimurium: genetic analysis a...

[ 1990, 2005, 1987, 1999, 2005 ]

5

[]

0

null

[ "Bacteria", "Caudoviricetes", "Hexamita inflata" ]

[ 1761, 132, 2 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

NAD biosynthesis/regulator protein NadR

NAD_NadR

5

IPR016431

16,431

Pyruvate-formate lyase-activating enzyme, predicted

Pyrv-formate_lyase-activ_prd

Family

6,413

false

This group represents a predicted pyruvate-formate lyase-activating enzyme including Uncharacterized protein MJ0674 and MJ0808.

[]

0

[ "PIRSF" ]

[ "PIRSF004869" ]

[ "PflX_prd" ]

[ 6413 ]

1

[]

0

[]

0

[]

0

[]

[ "IPR027596", "IPR040085" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 877, 4653, 689, 194 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Pyruvate-formate lyase-activating enzyme, predicted

Pyrv-formate_lyase-activ_prd

2

IPR016433

16,433

Small GTPase superfamily, Uncharacterized protein MJ1339

Small_GTPase_MJ1339

Family

18

false

This entry represents the Uncharacterized protein MJ1339 from Methanocaldococcus jannaschii, thought to be part of the wider small GTPase superfamily. Small GTPases form an independent superfamily within the larger class of regulatory GTP hydrolases. This superfamily contains proteins that control a vast number of impo...

[]

0

[ "PIRSF" ]

[ "PIRSF004882" ]

[ "GTP_bind_MJ1339_prd" ]

[ 18 ]

1

[]

0

[]

0

[ "PUB00000348", "PUB00004087", "PUB00015117", "PUB00023196", "PUB00052600" ]

[ "2029511", "1898771", "11995995", "2196171", "2122258" ]

[ "The ras protein family: evolutionary tree and role of conserved amino acids.", "The GTPase superfamily: conserved structure and molecular mechanism.", "Structure of small G proteins and their regulators.", "Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implicat...

[ 1991, 1991, 2001, 1990, 1990 ]

5

[]

0

null

[ "Methanomada group" ]

[ 18 ]

1

[]

0

true

Family

Small GTPase superfamily, Uncharacterized protein MJ1339

Small_GTPase_MJ1339

6

IPR016435

16,435

Diphthamide synthesis DPH1/DPH2

DPH1/DPH2

Family

11,988

false

Archaeal and eukaryotic translation elongation factor 2 contain a unique posttranslationally modified histidine residue called diphthamide, the target of the diphtheria toxin. Diphtheria toxin inhibits eukaryotic protein synthesis by ADP-ribosylating diphthamide in EF2 [ ]. Members of this family include 2-(3-amino-3-c...

[ "GO:0090560", "GO:0017183" ]

[ "2-(3-amino-3-carboxypropyl)histidine synthase activity", "protein histidyl modification to diphthamide" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PANTHER", "SFLD", "NCBIFAM" ]

[ "PF01866", "PTHR10762", "SFLDS00032", "TIGR00322" ]

[ "Diphthamide_syn", "", "Radical_SAM_3-amino-3-carboxyp", "diphth2_R" ]

[ 11273, 11228, 11660, 11338 ]

4

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-5358493", "R-DDI-5358493", "R-DRE-5358493", "R-HSA-5358493", "R-MMU-5358493", "R-SCE-5358493", "R-SPO-5358493" ]

[ "REACTOME:R-CEL-5358493", "REACTOME:R-DDI-5358493", "REACTOME:R-DRE-5358493", "REACTOME:R-HSA-5358493", "REACTOME:R-MMU-5358493", "REACTOME:R-SCE-5358493", "REACTOME:R-SPO-5358493" ]

7

[ "3lzc", "3lzd", "6bxk", "6bxl", "6bxm", "6bxn", "6bxo", "6q2d", "6q2e" ]

9

[ "PUB00017070", "PUB00059286", "PUB00101109" ]

[ "15485916", "20559380", "31463593" ]

[ "Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2.", "Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme.", "The asymmetric function of Dph1-Dph2 heterodimer in diphth...

[ 2004, 2010, 2019 ]

3

[]

[ "IPR010014", "IPR035435" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 948, 3, 10981, 56 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 2, 5, 2, 14, 3, 3, 7, 4, 2, 2, 9 ]

12

true

Family

Diphthamide synthesis DPH1/DPH2

DPH1/DPH2

5

IPR016436

16,436

Uncharacterised conserved protein UCP005063, CBS-type

UCP005063_CBS

Family

332

false

This group represents an uncharacterised protein with CBS domain pair, MJ1232 type.

[]

0

[ "PIRSF" ]

[ "PIRSF005063" ]

[ "UCP005063_CBS_MJ1232" ]

[ 332 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 326, 6 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP005063, CBS-type

UCP005063_CBS

6

IPR016437

16,437

MCT-1/Tma20

Family

6,105

false

This entry includes malignant T-cell-amplified sequence 1 (MCT-1) from animals and translation machinery-associated protein 20 (Tma20) from fungi. MCT-1 is an oncogene that plays a role in cell cycle regulation [ ]. The function of Tma20 is not clear. This entry also includes some uncharacterised proteins from archaea.

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF005067", "PTHR22798" ]

[ "Tma_RNA-bind_prd", "" ]

[ 4765, 6095 ]

2

[]

0

[ "1q7h", "1zs7", "2cx0", "2cx1", "3d79", "3r90", "5ons", "5vyc", "6ms4" ]

9

[ "PUB00078880" ]

[ "17016429" ]

[ "Phosphorylation of MCT-1 by p44/42 MAPK is required for its stabilization in response to DNA damage." ]

[ 2007 ]

1

[]

[ "IPR022430" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 883, 2, 5194, 26 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 1, 3, 2, 1, 2, 5, 1, 1, 13 ]

12

true

Family

MCT-1/Tma20

1

IPR016438

16,438

Circadian oscillator component FRH-like

FRH-like

Family

8,826

false

This family represents a group of ATP-dependent RNA helicases and their homologues, including Circadian oscillator component FRH (FRH), Superkiller complex protein 2 (SKI2) and RNA helicase Mtr4 (also known as Dob1). This entry also includes DExH-box ATP-dependent RNA helicase DExH9 from Arabidopsis thaliana which targ...

[ "GO:0003723", "GO:0003724", "GO:0006401" ]

[ "RNA binding", "RNA helicase activity", "RNA catabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF005198" ]

[ "Antiviral_helicase_SKI2" ]

[ 8826 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.6.4", "R-CEL-6791226", "R-CEL-72163", "R-CEL-9930044", "R-HSA-390471", "R-HSA-429958", "R-HSA-6791226", "R-HSA-72163", "R-HSA-9843970", "R-HSA-9930044", "R-MMU-429958", "R-MMU-6791226", "R-MMU-72163", "R-MMU-9930044", "R-SCE-429958", "R-SCE-6791226", "R-SPO-429958", "R-SPO-67912...

[ "EC:3.6.4", "REACTOME:R-CEL-6791226", "REACTOME:R-CEL-72163", "REACTOME:R-CEL-9930044", "REACTOME:R-HSA-390471", "REACTOME:R-HSA-429958", "REACTOME:R-HSA-6791226", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-9843970", "REACTOME:R-HSA-9930044", "REACTOME:R-MMU-429958", "REACTOME:R-MMU-6791226", "...

19

[ "2xgj", "4a4z", "4buj", "4qu4", "4u4c", "4xgt", "5dzr", "5e02", "5mc6", "5ooq", "6bb8", "6d6q", "6d6r", "6fsz", "6ft6", "6ieg", "6ieh", "6lqs", "6ro1", "7ajt", "7aju", "7d4i", "7qdr", "7qds", "7qdy", "7qdz", "7qe0", "7s7b", "7s7c", "7z4y", "7z4z", "7z52"...

42

[ "PUB00074525", "PUB00074526", "PUB00074527", "PUB00074528", "PUB00151108", "PUB00151109", "PUB00163261" ]

[ "23953113", "22532666", "25144737", "21855801", "32006463", "35120588", "40153515" ]

[ "The yeast ski complex: crystal structure and RNA channeling to the exosome complex.", "RNA unwinding by the Trf4/Air2/Mtr4 polyadenylation (TRAMP) complex.", "The RNA helicases AtMTR4 and HEN2 target specific subsets of nuclear transcripts for degradation by the nuclear exosome in Arabidopsis thaliana.", "In...

[ 2013, 2012, 2014, 2011, 2020, 2022, 2025 ]

7

[ "IPR050699" ]

[]

1

0

1

[ "Eukaryota" ]

[ 8826 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 2, 4, 3, 23, 8, 2, 6, 10, 2, 3, 25 ]

12

true

Family

Circadian oscillator component FRH-like

FRH-like

7

IPR016439

16,439

Sphingosine N-acyltransferase Lag1/Lac1-like

Lag1/Lac1-like

Family

17,202

false

Yeast ceramide synthase component Lag1 has a paralog, Lac1. This entry includes Lac1, Lag1 and their homologues from plants and animals [ , , ], involved in sphingolipid synthesis. LAG1 and LAC1 contain multiple membrane-spanning domains and are localised to the endoplasmic reticulum (ER) [ ]. They are essential subuni...

[ "GO:0050291", "GO:0046513" ]

[ "sphingosine N-acyltransferase activity", "ceramide biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF005225", "PTHR12560" ]

[ "LAG1_LAC1", "" ]

[ 10715, 17101 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.3.1", "R-BTA-1660661", "R-CEL-1660661", "R-HSA-1660661", "R-MMU-1660661", "R-SCE-1660661", "R-SPO-1660661" ]

[ "EC:2.3.1", "REACTOME:R-BTA-1660661", "REACTOME:R-CEL-1660661", "REACTOME:R-HSA-1660661", "REACTOME:R-MMU-1660661", "REACTOME:R-SCE-1660661", "REACTOME:R-SPO-1660661" ]

7

[ "1x2m", "2cqx", "8izd", "8izf", "8qtn", "8qtr", "8qz6", "8qz7", "8y2m", "8y2n", "8zb1", "9eot" ]

12

[ "PUB00009697", "PUB00073468", "PUB00073469", "PUB00073470", "PUB00073471", "PUB00073472", "PUB00073765", "PUB00097253" ]

[ "11694577", "10198056", "15692566", "15236759", "12105227", "12445127", "25213553", "26276842" ]

[ "Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae.", "Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins.", "Lip1p: a novel subunit of acyl-CoA ceramide synthase.",...

[ 2001, 1999, 2005, 2004, 2002, 2002, 2014, 2015 ]

8

[]

0

null

[ "Coccolithovirus", "Eukaryota", "viral metagenome" ]

[ 12, 17189, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 17, 5, 30, 1, 31, 17, 2, 10, 18, 2, 2, 49 ]

12

true

Family

Sphingosine N-acyltransferase Lag1/Lac1-like

Lag1/Lac1-like

8

IPR016440

16,440

Rubredoxin-oxygen oxidoreductase

Rubredoxin-O_OxRdtase

Family

6,183

false

This entry represents rubredoxin-oxygen oxidoreductases. This includes enzymes such as the flavorubredoxin oxidoreductase NorV (or nitric oxide reductase flavorubredoxin) that contains one rubredoxin domain and binds FMN as a cofatror, acting to sense nitric oxide (NO) by formation of a mono-nitrosyl iron complex. NorV...

[ "GO:0009055", "GO:0010181", "GO:0016491", "GO:0046872" ]

[ "electron transfer activity", "FMN binding", "oxidoreductase activity", "metal ion binding" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function" ]

4

[ "PIRSF" ]

[ "PIRSF005243" ]

[ "ROO" ]

[ 6183 ]

1

[]

0

[ "1e5d", "1vme", "1ycf", "1ycg", "1ych", "2ohh", "2ohi", "2ohj", "2q9u", "4d02", "4dik", "4dil", "5lld", "5lmc", "5v8s", "6etb", "6frm", "6frn", "6zk8", "6zlf", "7r0f", "7r1h", "7r1j", "7r2o", "7r2p", "7r2r", "7r2s" ]

27

[ "PUB00032624", "PUB00042197", "PUB00042734", "PUB00042735", "PUB00042737", "PUB00093740" ]

[ "15850383", "17480207", "16417519", "15667306", "7649162", "15340796" ]

[ "X-ray crystal structures of Moorella thermoacetica FprA. Novel diiron site structure and mechanistic insights into a scavenging nitric oxide reductase.", "Structure of coenzyme F420H2 oxidase (FprA), a di-iron flavoprotein from methanogenic Archaea catalyzing the reduction of O2 to H2O.", "Mechanism of transcr...

[ 2005, 2007, 2006, 2005, 1995, 2004 ]

6

[]

[ "IPR023957" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "Phage sp. ctIHi3", "unclassified sequences" ]

[ 525, 5450, 131, 1, 76 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Rubredoxin-oxygen oxidoreductase

Rubredoxin-O_OxRdtase

1

IPR016442

16,442

tRNA-splicing endonuclease, archaeal short subfamily

tRNA_splic_arch_short

Family

393

false

This group represents a tRNA-splicing endonuclease belonging to the archaeal short subfamily [ ]. tRNA-splicing endonucleases ( ) catalyse the endonucleolytic cleavage of pre tRNA at the 5' and 3' splice sites to release the intron and produces two half tRNA molecules bearing 5' hydroxyl and 2', 3'-cyclic phosphate ter...

[]

0

[ "HAMAP", "PIRSF" ]

[ "MF_01833", "PIRSF005285" ]

[ "EndA_short", "tRNA_splic_archaea" ]

[ 170, 393 ]

2

[ "EC", "METACYC", "METACYC" ]

[ "4.6.1.16", "PWY-6689", "PWY-7803" ]

[ "EC:4.6.1.16", "METACYC:PWY-6689", "METACYC:PWY-7803" ]

3

[ "1a79", "2cv8", "2zyz", "3ajv", "3iey", "3p1z", "5x89" ]

7

[ "PUB00054270", "PUB00055529" ]

[ "9321408", "9200603" ]

[ "RNA-protein interactions of an archaeal homotetrameric splicing endoribonuclease with an exceptional evolutionary history.", "The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases." ]

[ 1997, 1997 ]

2

[ "IPR006676" ]

[]

1

0

1

[ "Archaea", "Candidatus Staskawiczbacteria bacterium RIFOXYD1_FULL_32_13", "unclassified sequences" ]

[ 379, 1, 13 ]

3

[]

0

true

Family

tRNA-splicing endonuclease, archaeal short subfamily

tRNA_splic_arch_short

4

IPR016443

16,443

RNA 3'-terminal phosphate cyclase type 2

RNA3'_term_phos_cyc_type_2

Family

4,387

false

This entry represents the type 2 RNA 3'-terminal phosphate cyclases, also known as RNA'-terminal-phosphate-cyclase-like (Rcl) proteins [ ]. RNA cyclases are a family of RNA-modifying enzymes that are conserved in eukaryotes, bacteria and archaea. Type 1 RNA 3'-terminal phosphate cyclases ( ) [ , ] catalyse the conversi...

[ "GO:0042254", "GO:0005730" ]

[ "ribosome biogenesis", "nucleolus" ]

[ "biological_process", "cellular_component" ]

2

[ "NCBIFAM", "CDD" ]

[ "TIGR03400", "cd00875" ]

[ "18S_RNA_Rcl1p", "RNA_Cyclase_Class_I" ]

[ 4381, 3374 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6791226", "R-CEL-6791226", "R-DDI-6791226", "R-DME-6791226", "R-HSA-6790901", "R-HSA-6791226", "R-MMU-6791226", "R-SCE-6791226", "R-SPO-6791226" ]

[ "REACTOME:R-BTA-6791226", "REACTOME:R-CEL-6791226", "REACTOME:R-DDI-6791226", "REACTOME:R-DME-6791226", "REACTOME:R-HSA-6790901", "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-SCE-6791226", "REACTOME:R-SPO-6791226" ]

9

[ "3pqv", "4clq", "5jpq", "5oql", "5tzs", "5wlc", "5wyj", "5wyk", "6ke6", "6lqp", "6lqq", "6lqr", "6lqs", "6lqt", "6lqu", "6lqv", "6rxt", "6rxu", "6rxv", "6rxx", "6rxy", "6rxz", "6zqa", "6zqb", "6zqc", "6zqd", "6zqe", "6zqf", "6zqg", "7ajt", "7aju", "7d4i"...

56

[ "PUB00001300", "PUB00003565", "PUB00042947" ]

[ "9184239", "2199762", "10790377" ]

[ "The human RNA 3'-terminal phosphate cyclase is a member of a new family of proteins conserved in Eucarya, Bacteria and Archaea.", "RNA 3'-terminal phosphate cyclase from HeLa cells.", "Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase, associates with U3 snoRNP and is required for 18S rRNA bioge...

[ 1997, 1990, 2000 ]

3

[ "IPR000228" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4387 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 1, 2, 3, 1, 3, 4, 1, 1, 4 ]

12

true

Family

RNA 3'-terminal phosphate cyclase type 2

RNA3'_term_phos_cyc_type_2

6

IPR016444

16,444

Synaptobrevin/Vesicle-associated membrane protein

Synaptobrevin/VAMP

Family

8,974

false

This entry includes vesicle-associated membrane proteins VAMP1/synaptobrevin-1, VAMP2/synaptobrevin-2, VAMP3/synaptobrevin-3 and VAMP8/endobrevin. VAMPs are a group of small, integral membrane proteins of synaptic vesicles that is mostly involved in vesicle fusion. The heterotrimeric SNARE complex is formed by syntaxin...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF005409", "PTHR45701" ]

[ "Synaptobrevin_euk", "" ]

[ 4584, 8749 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1236974", "R-BTA-181429", "R-BTA-181430", "R-BTA-199992", "R-BTA-210500", "R-BTA-212676", "R-BTA-264642", "R-BTA-432720", "R-BTA-432722", "R-BTA-449836", "R-BTA-6798695", "R-BTA-8856825", "R-BTA-8856828", "R-BTA-888590", "R-BTA-9609523", "R-CEL-181429", "R-CEL-181430", "R-CE...

[ "REACTOME:R-BTA-1236974", "REACTOME:R-BTA-181429", "REACTOME:R-BTA-181430", "REACTOME:R-BTA-199992", "REACTOME:R-BTA-210500", "REACTOME:R-BTA-212676", "REACTOME:R-BTA-264642", "REACTOME:R-BTA-432720", "REACTOME:R-BTA-432722", "REACTOME:R-BTA-449836", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-8...

170

[ "1gl2", "1kil", "1l4a", "1n7s", "1sfc", "2kog", "2n1t", "2nps", "3b5n", "3fie", "3fii", "3hd7", "3ipd", "3j96", "3j97", "3j98", "3j99", "3rk2", "3rk3", "3rl0", "4wy4", "5ccg", "5cch", "5cci", "5kj7", "5kj8", "5w5c", "5w5d", "6ip1", "6mdm", "6mdn", "6mti"...

44

[ "PUB00069067", "PUB00069670", "PUB00073610", "PUB00073611", "PUB00073612" ]

[ "21282288", "12145198", "8221884", "15363411", "17215514" ]

[ "The role of synaptobrevin1/VAMP1 in Ca2+-triggered neurotransmitter release at the mouse neuromuscular junction.", "Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis.", "A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicl...

[ 2011, 2002, 1993, 2004, 2007 ]

5

[ "IPR001388" ]

[]

1

0

1

[ "Eukaryota", "Pseudomonadota", "Viruses", "metagenomes" ]

[ 8952, 8, 8, 6 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 9, 8, 4, 16, 16, 1, 23, 3, 1, 2 ]

10

true

Family

Synaptobrevin/Vesicle-associated membrane protein

Synaptobrevin/VAMP

6

IPR016445

16,445

Lipase Rog1

Rog1_fam

Family

706

false

This entry represents a group of lipases, including budding yeast Rog1. Rog1 is a monoacylglycerol (MAG) lipase that regulates lipid homeostasis [ ]. This entry also includes Rog1 paralogue YDL109C and the uncharacterised proteins YDR444W and C4A8.10.

[]

0

[ "PIRSF" ]

[ "PIRSF005412" ]

[ "UCP005412_abhydr" ]

[ 706 ]

1

[]

0

[]

0

[ "PUB00073766" ]

[ "25433290" ]

[ "ROG1 encodes a monoacylglycerol lipase in Saccharomyces cerevisiae." ]

[ 2015 ]

1

[ "IPR044294" ]

[]

1

0

1

[ "Dikarya" ]

[ 706 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 1 ]

2

true

Family

Lipase Rog1

Rog1_fam

4

IPR016447

16,447

Translocation associated membrane protein

Translocation_assoc_membrane

Family

3,662

false

This group represents a translocation associated membrane protein.

[ "GO:0006616" ]

[ "SRP-dependent cotranslational protein targeting to membrane, translocation" ]

[ "biological_process" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF005449", "PTHR12371" ]

[ "Translocation_assoc_membrane", "" ]

[ 2450, 3662 ]

2

[ "REACTOME" ]

[ "R-HSA-1799339" ]

[ "REACTOME:R-HSA-1799339" ]

1

[]

0

[]

0

[]

0

null

[ "Opisthokonta" ]

[ 3662 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 9, 2, 11, 10, 13 ]

6

true

Family

Translocation associated membrane protein

Translocation_assoc_membrane

1

IPR016449

16,449

Potassium channel, inwardly rectifying, Kir

K_chnl_inward-rec_Kir

Family

22,104

false

Potassium channels are the most diverse group of the ion channel family [ , ]. They are important in shaping the action potential, and in neuronal excitability and plasticity [ ]. The potassium channel family is composed of several functionally distinct isoforms, which can be broadly separated into 2 groups [ ]: the pr...

[ "GO:0005242", "GO:0006813", "GO:0016020" ]

[ "inward rectifier potassium channel activity", "potassium ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF", "PRINTS", "PANTHER" ]

[ "PIRSF005465", "PR01320", "PTHR11767" ]

[ "GIRK_kir", "KIRCHANNEL", "" ]

[ 10993, 20705, 22059 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1296041", "R-BTA-1296053", "R-BTA-5576886", "R-BTA-997272", "R-CEL-1296041", "R-CEL-1296053", "R-CEL-1296067", "R-CEL-5576886", "R-CEL-997272", "R-CFA-1296041", "R-CFA-1296053", "R-CFA-5576886", "R-CFA-997272", "R-GGA-1296041", "R-GGA-1296053", "R-GGA-5576886", "R-GGA-997272",...

[ "REACTOME:R-BTA-1296041", "REACTOME:R-BTA-1296053", "REACTOME:R-BTA-5576886", "REACTOME:R-BTA-997272", "REACTOME:R-CEL-1296041", "REACTOME:R-CEL-1296053", "REACTOME:R-CEL-1296067", "REACTOME:R-CEL-5576886", "REACTOME:R-CEL-997272", "REACTOME:R-CFA-1296041", "REACTOME:R-CFA-1296053", "REACTOME:...

51

[ "1n9p", "1p7b", "1u4e", "1u4f", "1xl4", "1xl6", "2e4f", "2gix", "2qks", "2wlh", "2wli", "2wlj", "2wlk", "2wll", "2wlm", "2wln", "2wlo", "2x6a", "2x6b", "2x6c", "2xky", "3agw", "3at8", "3at9", "3ata", "3atb", "3atd", "3ate", "3atf", "3auw", "3jyc", "3k6n"...

110

[ "PUB00001055", "PUB00001069", "PUB00001622", "PUB00002771", "PUB00004011", "PUB00004020", "PUB00006577", "PUB00009378", "PUB00009410", "PUB00009411" ]

[ "1772658", "7580148", "1879548", "1373731", "2448635", "2451788", "2555158", "11178249", "10102275", "10449331" ]

[ "The molecular biology of K+ channels.", "The inward rectifier potassium channel family.", "Shaw-like rat brain potassium channel cDNA's with divergent 3' ends.", "Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.", "Multiple potassium-channel components are produced ...

[ 1991, 1995, 1991, 1992, 1988, 1988, 1989, 2000, 1999, 1999 ]

10

[]

[ "IPR003268", "IPR003269", "IPR003270", "IPR003271", "IPR003272", "IPR003273", "IPR003274", "IPR003275", "IPR003276", "IPR003277", "IPR003278", "IPR003279", "IPR008061", "IPR008062" ]

0

14

0

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1616, 20474, 14 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 49, 19, 60, 59, 70 ]

6

true

Family

Potassium channel, inwardly rectifying, Kir

K_chnl_inward-rec_Kir

4

IPR016450

16,450

Uncharacterised conserved protein UCP005522

UCP005522

Family

8,868

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF005522" ]

[ "UCP005522" ]

[ 8868 ]

1

[]

0

[ "3n6x" ]

1

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Thermoproteati", "metagenomes" ]

[ 8789, 10, 24, 45 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP005522

UCP005522

5

IPR016451

16,451

Intermediate filament, ifa/ifb

Intermed_filament_ifa/ifb

Family

511

false

Intermediate filaments (IF) [ , , ] are proteins which are primordial components of the cytoskeleton and the nuclear envelope. All IF proteins are structurally similar in that they consist of: a central rod domain comprising some 300 to 350 residues which is arranged in coiled-coiled α-helices, with at least two short ...

[]

0

[ "PIRSF" ]

[ "PIRSF005546" ]

[ "Intermed_filamnt_Ifb-2" ]

[ 511 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-2559584", "R-CEL-4419969", "R-CEL-9013405", "R-CEL-9035034" ]

[ "REACTOME:R-CEL-2559584", "REACTOME:R-CEL-4419969", "REACTOME:R-CEL-9013405", "REACTOME:R-CEL-9035034" ]

4

[]

0

[ "PUB00000058", "PUB00001053", "PUB00004976", "PUB00059259", "PUB00059260" ]

[ "3052284", "2183847", "8771189", "2583097", "11427699" ]

[ "Molecular and cellular biology of intermediate filaments.", "Intermediate filaments: structure, assembly and molecular interactions.", "Intermediate filament proteins.", "Cytoplasmic intermediate filament proteins of invertebrates are closer to nuclear lamins than are vertebrate intermediate filament protein...

[ 1988, 1990, 1995, 1989, 2001 ]

5

[]

0

null

[ "Protostomia" ]

[ 511 ]

1

[ "Caenorhabditis elegans" ]

[ 8 ]

1

true

Family

Intermediate filament, ifa/ifb

Intermed_filament_ifa/ifb

7

IPR016452

16,452

Fatty acid synthase beta subunit AflB /Fas1-like, fungi

Fas1/AflB-like

Family

1,737

false

This entry represents a fatty acid synthase beta subunit found in fungi, including Fas1 from yeasts and aflB from Aspergillus parasiticus. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reducta...

[ "GO:0004313", "GO:0004314", "GO:0004318", "GO:0019171", "GO:0006633", "GO:0005835" ]

[ "[acyl-carrier-protein] S-acetyltransferase activity", "[acyl-carrier-protein] S-malonyltransferase activity", "enoyl-[acyl-carrier-protein] reductase (NADH) activity", "(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity", "fatty acid biosynthetic process", "fatty acid synthase complex" ]

[ "molecular_function", "molecular_function", "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

6

[ "PIRSF" ]

[ "PIRSF005562" ]

[ "FAS_yeast_beta" ]

[ 1737 ]

1

[ "EC", "EC", "EC", "EC", "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC...

[ "1.3.1.9", "2.3.1.38", "2.3.1.39", "2.3.1.86", "3.1.2.14", "4.2.1.59", "PWY-4381", "PWY-5142", "PWY-5147", "PWY-5366", "PWY-5367", "PWY-5966", "PWY-5971", "PWY-5973", "PWY-5989", "PWY-5994", "PWY-6113", "PWY-6282", "PWY-6519", "PWY-6799", "PWY-7388", "PWY-7663", "PWY-7664...

[ "EC:1.3.1.9", "EC:2.3.1.38", "EC:2.3.1.39", "EC:2.3.1.86", "EC:3.1.2.14", "EC:4.2.1.59", "METACYC:PWY-4381", "METACYC:PWY-5142", "METACYC:PWY-5147", "METACYC:PWY-5366", "METACYC:PWY-5367", "METACYC:PWY-5966", "METACYC:PWY-5971", "METACYC:PWY-5973", "METACYC:PWY-5989", "METACYC:PWY-5994...

38

[ "2uv8", "2vkz", "3hmj", "4v58", "4v59", "6ql5", "6ql6", "6ql7", "6ql9", "6ta1", "6u5t", "6u5u", "6u5v", "6u5w", "6wc7", "7bc4", "7q5s", "7tui", "8prv", "8prw", "8ps1", "8ps2", "8ps8", "8ps9", "8psa", "8psf", "8psg", "8psj", "8psk", "8psl", "8psm", "8psp"...

38

[ "PUB00006544", "PUB00083132" ]

[ "3528750", "15006741" ]

[ "The pentafunctional FAS1 gene of yeast: its nucleotide sequence and order of the catalytic domains.", "Clustered pathway genes in aflatoxin biosynthesis." ]

[ 1986, 2004 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1737 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Fatty acid synthase beta subunit AflB /Fas1-like, fungi

Fas1/AflB-like

5

IPR016453

16,453

Coatomer beta' subunit (COPB2)

COPB2

Family

5,464

false

Proteins synthesised on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. This traffic is bidirectional, to ensure that proteins required to form vesicles ar...

[]

0

[ "PIRSF" ]

[ "PIRSF005567" ]

[ "Coatomer_beta'_subunit" ]

[ 5464 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-6807878", "R-BTA-6811434", "R-CEL-6807878", "R-CEL-6811434", "R-DDI-6807878", "R-DDI-6811434", "R-DME-6807878", "R-DME-6811434", "R-HSA-6807878", "R-HSA-6811434", "R-MMU-6807878", "R-MMU-6811434", "R-RNO-6807878", "R-RNO-6811434", "R-SCE-6807878", "R-SCE-6811434", "R-SPO-68078...

[ "REACTOME:R-BTA-6807878", "REACTOME:R-BTA-6811434", "REACTOME:R-CEL-6807878", "REACTOME:R-CEL-6811434", "REACTOME:R-DDI-6807878", "REACTOME:R-DDI-6811434", "REACTOME:R-DME-6807878", "REACTOME:R-DME-6811434", "REACTOME:R-HSA-6807878", "REACTOME:R-HSA-6811434", "REACTOME:R-MMU-6807878", "REACTOM...

18

[ "3mkq", "5a1u", "5a1v", "5a1w", "5a1x", "5a1y", "5nzr", "5nzs", "5nzt", "5nzu", "5nzv", "9qpq" ]

12

[ "PUB00030524", "PUB00035767", "PUB00035768", "PUB00035769", "PUB00100149", "PUB00103198", "PUB00103201" ]

[ "14690497", "11208122", "17041781", "15261670", "26160949", "28621666", "34450031" ]

[ "Gamma-COP appendage domain - structure and function.", "Traffic COPs of the early secretory pathway.", "COPI-mediated transport.", "COP and clathrin-coated vesicle budding: different pathways, common approaches.", "VESICULAR TRANSPORT. A structure of the COPI coat and the role of coat proteins in membrane ...

[ 2004, 2000, 2006, 2004, 2015, 2017, 2021 ]

7

[]

0

null

[ "Eukaryota" ]

[ 5464 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 19, 1, 1, 1, 4, 1, 1, 6, 5, 1, 1, 66 ]

12

true

Family

Coatomer beta' subunit (COPB2)

COPB2

5

IPR016456

16,456

Predicted cobalamin-independent methionine synthase, catalytic subunit

Met_Synthase_cat

Family

2,649

false

This group represents a predicted cobalamin-independent methionine synthase, catalytic subunit.

[]

0

[ "NCBIFAM", "PIRSF" ]

[ "NF006589", "PIRSF005632" ]

[ "PRK09121.1", "Met_synth_catalytic_prd" ]

[ 2648, 2530 ]

2

[]

0

[ "3rpd" ]

1

[ "PUB00104347" ]

[ "18319726" ]

[ "A complete collection of single-gene deletion mutants of Acinetobacter baylyi ADP1." ]

[ 2008 ]

1

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 2630, 6, 13 ]

3

[]

0

true

Family

Predicted cobalamin-independent methionine synthase, catalytic subunit

Met_Synthase_cat

1

IPR016457

16,457

Formylmethanofuran dehydrogenase, subunit B

Formylmethanofuran_DH_bsu

Family

814

false

This entry represents subunit B (FmdB and FwdB) of formylmethanofuran dehydrogenase. The other subunits are subunit A ( ), subunit C ( ), subunit D ( ), subunit E ( ) and subunit F. Some organisms also encode a fusion of the C and D subunits ( ). Formylmethanofuran dehydrogenase catalyzes the first step in methane form...

[ "GO:0018493", "GO:0015948" ]

[ "formylmethanofuran dehydrogenase activity", "methanogenesis" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF", "NCBIFAM", "CDD" ]

[ "PIRSF005646", "TIGR03129", "cd02761" ]

[ "FwdB", "one_C_dehyd_B", "MopB_FmdB-FwdB" ]

[ 718, 734, 659 ]

3

[ "GP" ]

[ "GenProp0671" ]

[ "GP:GenProp0671" ]

1

[ "5t5i", "5t5m", "5t61", "7bkb", "7bkc", "8rja" ]

6

[ "PUB00000170", "PUB00008259", "PUB00015859", "PUB00016174", "PUB00042893", "PUB00042895" ]

[ "9818358", "8125106", "8575452", "8954165", "9342247", "12492476" ]

[ "The formylmethanofuran dehydrogenase isoenzymes in Methanobacterium wolfei and Methanobacterium thermoautotrophicum: induction of the molybdenum isoenzyme by molybdate and constitutive synthesis of the tungsten isoenzyme.", "Formylmethanofuran dehydrogenases from methanogenic Archaea. Substrate specificity, EPR ...

[ 1998, 1994, 1995, 1996, 1997, 2003 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Durusdinium trenchii", "ecological metagenomes" ]

[ 595, 193, 2, 24 ]

4

[]

0

true

Family

Formylmethanofuran dehydrogenase, subunit B

Formylmethanofuran_DH_bsu

3

IPR016458

16,458

Uncharacterised conserved protein UCP005648, calcium-binding

UCP005648_Ca-bd

Family

12

false

The structure of the Methanobacterium thermoautotrophicum protein encoded by MTH1880 demonstrates the typical α + β fold found in many proteins with different functions [ ]. The molecular surface of the protein reveals a small, highly acidic pocket. MTH1880 protein contains a novel motif for calcium-specific binding, b...

[]

0

[ "PIRSF" ]

[ "PIRSF005648" ]

[ "UCP005648_Ca-bd" ]

[ 12 ]

1

[]

0

[ "1iqo", "1iqs" ]

2

[ "PUB00035934" ]

[ "15044740" ]

[ "Solution structure of a novel calcium binding protein, MTH1880, from Methanobacterium thermoautotrophicum." ]

[ 2004 ]

1

[ "IPR008032" ]

[]

1

0

1

[ "Methanomada group" ]

[ 12 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP005648, calcium-binding

UCP005648_Ca-bd

1

IPR016460

16,460

Coatomer beta subunit (COPB1)

COPB1

Family

5,995

false

Proteins synthesised on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. This traffic is bidirectional, to ensure that proteins required to form vesicles ar...

[ "GO:0006886", "GO:0005737" ]

[ "intracellular protein transport", "cytoplasm" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF005727", "PTHR10635" ]

[ "Coatomer_beta_subunit", "" ]

[ 4546, 5995 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-6798695", "R-BTA-6807878", "R-BTA-6811434", "R-DDI-6798695", "R-DDI-6807878", "R-DDI-6811434", "R-DME-6798695", "R-DME-6807878", "R-DME-6811434", "R-DRE-6798695", "R-DRE-6807878", "R-DRE-6811434", "R-GGA-6798695", "R-GGA-6807878", "R-GGA-6811434", "R-HSA-6798695", "R-HSA-68078...

[ "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-6807878", "REACTOME:R-BTA-6811434", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-6807878", "REACTOME:R-DDI-6811434", "REACTOME:R-DME-6798695", "REACTOME:R-DME-6807878", "REACTOME:R-DME-6811434", "REACTOME:R-DRE-6798695", "REACTOME:R-DRE-6807878", "REACTOM...

30

[ "5a1u", "5a1v", "5a1w", "5a1x", "5a1y", "5mu7", "5nzr", "5nzs", "5nzt", "5nzu", "5nzv", "9qpq" ]

12

[ "PUB00030524", "PUB00035767", "PUB00035768", "PUB00035769", "PUB00100149", "PUB00103198" ]

[ "14690497", "11208122", "17041781", "15261670", "26160949", "28621666" ]

[ "Gamma-COP appendage domain - structure and function.", "Traffic COPs of the early secretory pathway.", "COPI-mediated transport.", "COP and clathrin-coated vesicle budding: different pathways, common approaches.", "VESICULAR TRANSPORT. A structure of the COPI coat and the role of coat proteins in membrane ...

[ 2004, 2000, 2006, 2004, 2015, 2017 ]

6

[]

0

null

[ "Eukaryota", "Legionella steelei" ]

[ 5994, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 1, 4, 1, 1, 6, 4, 1, 1, 30 ]

12

true

Family

Coatomer beta subunit (COPB1)

COPB1

1

IPR016462

16,462

Molybdate-dependent transcriptional regulator ModE

ModE

Family

4,213

false

The ModE-Mo complex acts as a repressor of the modABC operon, which is involved in the transport of molybdate. Upon binding molybdate, the conformation of the protein changes, promoting dimerization of ModE-Mo. The protein dimer is then competent to bind a DNA region, upstream of the modABC operon, which contains an 8-...

[ "GO:0030151", "GO:0006355", "GO:0015689" ]

[ "molybdenum ion binding", "regulation of DNA-templated transcription", "molybdate ion transport" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF005763" ]

[ "Txn_reg_ModE" ]

[ 4213 ]

1

[ "GP" ]

[ "GenProp1121" ]

[ "GP:GenProp1121" ]

1

[ "1b9m", "1b9n", "1o7l" ]

3

[ "PUB00008215" ]

[ "9210473" ]

[ "Characterisation of the molybdenum-responsive ModE regulatory protein and its binding to the promoter region of the modABCD (molybdenum transport) operon of Escherichia coli." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Beauveria bassiana D1-5", "Methanobacteriota", "unclassified sequences" ]

[ 4046, 1, 144, 22 ]

4

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Molybdate-dependent transcriptional regulator ModE

ModE

9

IPR016463

16,463

Electron transport complex, RnfB/RsxB, Proteobacteria

RnfB/RsxB_Proteobac

Family

3,736

false

This family of proteins is made up of electron transport complex subunit RnfB and RsxB, mainly from Proteobacteria. The six subunit complex RnfABCDGE in Rhodobacter capsulatus (Rhodopseudomonas capsulata) encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen f...

[ "GO:0051536", "GO:0022900", "GO:0005886" ]

[ "iron-sulfur cluster binding", "electron transport chain", "plasma membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF005784" ]

[ "Elect_transpt_RnfB" ]

[ 3736 ]

1

[]

0

[ "8ahx", "8rb8", "8rb9", "8rbm", "8rbq" ]

5

[ "PUB00007528", "PUB00013513", "PUB00020279", "PUB00062387" ]

[ "9154934", "12773378", "8264535", "10671439" ]

[ "Membrane localization, topology, and mutual stabilization of the rnfABC gene products in Rhodobacter capsulatus and implications for a new family of energy-coupling NADH oxidoreductases.", "A reducing system of the superoxide sensor SoxR in Escherichia coli.", "Identification of a new class of nitrogen fixatio...

[ 1997, 2003, 1993, 2000 ]

4

[ "IPR010207" ]

[]

1

0

1

[ "Bacteria", "Capitella teleta", "unclassified sequences" ]

[ 3680, 1, 55 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Electron transport complex, RnfB/RsxB, Proteobacteria

RnfB/RsxB_Proteobac

5

IPR016464

16,464

NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2

NADH_Ub_cplx-1_asu_su-2

Family

3,770

false

This group represents a NADH dehydrogenase [ubiquinone (complex I), alpha subcomplex, subunit 2.

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF005822", "PTHR12878" ]

[ "NDUA2", "" ]

[ 3164, 3770 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-611105", "R-BTA-6799198", "R-BTA-9837999", "R-HSA-611105", "R-HSA-6799198", "R-HSA-9837999", "R-MMU-611105", "R-MMU-6799198", "R-MMU-9837999" ]

[ "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-BTA-9837999", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198", "REACTOME:R-MMU-9837999" ]

9

[ "1s3a", "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtb", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6q9d", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6rfq", "6rfr", "6rfs", "6x89"...

260

[]

0

[]

0

null

[ "Eukaryota", "Solihabitans fulvus" ]

[ 3769, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 2, 1, 1, 1, 1, 1, 1, 4, 3, 5 ]

10

true

Family

NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2

NADH_Ub_cplx-1_asu_su-2

3

IPR016466

16,466

Methanogenesis marker 3 protein

Methan_mark_3

Family

267

false

Members of this protein family are only found in archaeal methanogens. The functions of proteins in this family are unknown, but their role is likely one essential to methanogenesis [ ]. More recent work showed that member protein MA3997 from Methanosarcina acetivorans C2A co-purified with affinity-purified methyl-coen...

[]

0

[ "HAMAP", "PIRSF", "NCBIFAM" ]

[ "MF_01089", "PIRSF005852", "TIGR03268" ]

[ "UPF0288", "UCP005852", "methan_mark_3" ]

[ 253, 261, 267 ]

3

[ "GP" ]

[ "GenProp0722" ]

[ "GP:GenProp0722" ]

1

[ "8s7v", "8s7x", "9h1l" ]

3

[ "PUB00060475", "PUB00093716" ]

[ "22070167", "28880150" ]

[ "ProPhylo: partial phylogenetic profiling to guide protein family construction and assignment of biological process.", "Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea." ]

[ 2011, 2017 ]

2

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 262, 5 ]

2

[]

0

true

Family

Methanogenesis marker 3 protein

Methan_mark_3

7

IPR016467

16,467

DNA recombination and repair protein, RecA-like

DNA_recomb/repair_RecA-like

Family

11,880

false

The recA gene product is a multifunctional enzyme that plays a role in homologous recombination, DNA repair and induction of the SOS response [ ]. In homologous recombination, the protein functions as a DNA-dependent ATPase, promoting synapsis, heteroduplex formation and strand exchange between homologous DNAs [ ]. Rec...

[]

0

[ "PIRSF" ]

[ "PIRSF005856" ]

[ "Rad51" ]

[ 11880 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-5685938", "R-BTA-5685942", "R-BTA-5693568", "R-BTA-5693579", "R-BTA-5693616", "R-BTA-912446", "R-CFA-5685938", "R-CFA-5685942", "R-CFA-5693568", "R-CFA-5693579", "R-CFA-5693616", "R-CFA-912446", "R-DME-5693616", "R-GGA-265976", "R-GGA-351433", "R-GGA-5685938", "R-GGA-5685942",...

[ "REACTOME:R-BTA-5685938", "REACTOME:R-BTA-5685942", "REACTOME:R-BTA-5693568", "REACTOME:R-BTA-5693579", "REACTOME:R-BTA-5693616", "REACTOME:R-BTA-912446", "REACTOME:R-CFA-5685938", "REACTOME:R-CFA-5685942", "REACTOME:R-CFA-5693568", "REACTOME:R-CFA-5693579", "REACTOME:R-CFA-5693616", "REACTOME...

45

[ "1pzn", "1szp", "1t4g", "1v5w", "1xu4", "2b21", "2bke", "2dfl", "2f1h", "2f1i", "2f1j", "2fpk", "2fpl", "2fpm", "2i1q", "2z43", "2zjb", "2zub", "2zuc", "2zud", "3etl", "3ew9", "3ewa", "3fyh", "3lda", "3ntu", "5h1b", "5h1c", "5jzc", "5np7", "5nwl", "7c98"...

82

[ "PUB00002285", "PUB00003439", "PUB00003747", "PUB00004797", "PUB00004946", "PUB00043276" ]

[ "7592482", "8587109", "1896024", "1518831", "9187054", "12045091" ]

[ "Bacterial classifications derived from recA protein sequence comparisons.", "The RecA protein as a model molecule for molecular systematic studies of bacteria: comparison of trees of RecAs and 16S rRNAs from the same species.", "Characterization of recA genes and recA mutants of Rhizobium meliloti and Rhizobiu...

[ 1995, 1995, 1991, 1992, 1997, 2002 ]

6

[]

[ "IPR011938", "IPR011940", "IPR011941", "IPR030548" ]

0

4

0

[ "Archaea", "Druskaviridae", "Eukaryota", "Patescibacteria group", "unclassified sequences" ]

[ 960, 2, 10878, 2, 38 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 22, 3, 12, 2, 11, 13, 1, 16, 21, 2, 3, 24 ]

12

true

Family

DNA recombination and repair protein, RecA-like

DNA_recomb/repair_RecA-like

1

IPR016468

16,468

CCAAT/enhancer-binding protein, chordates

C/EBP_chordates

Family

1,694

false

This group represents a CCAAT/enhancer-binding protein.CCAAT/enhancer-binding proteins (C/EBPs) are basic region leucine zipper (bZIP) transcription factors. They regulate cell differentiation, growth, survival, and inflammation [ ]. They function in a variety of tissues. The prototypic C/EBP is a modular protein, cons...

[]

0

[ "PIRSF" ]

[ "PIRSF005879" ]

[ "CCAAT/enhancer-binding" ]

[ 1694 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-GGA-2559582", "R-HSA-2559582", "R-HSA-380994", "R-HSA-381340", "R-HSA-6785807", "R-HSA-8853884", "R-HSA-9610379", "R-HSA-9616222", "R-HSA-9633012", "R-HSA-9648895", "R-HSA-9725371", "R-HSA-9841922", "R-MMU-2559582", "R-MMU-9616222", "R-RNO-2559582", "R-RNO-9616222" ]

[ "REACTOME:R-GGA-2559582", "REACTOME:R-HSA-2559582", "REACTOME:R-HSA-380994", "REACTOME:R-HSA-381340", "REACTOME:R-HSA-6785807", "REACTOME:R-HSA-8853884", "REACTOME:R-HSA-9610379", "REACTOME:R-HSA-9616222", "REACTOME:R-HSA-9633012", "REACTOME:R-HSA-9648895", "REACTOME:R-HSA-9725371", "REACTOME:...

16

[]

0

[ "PUB00029248", "PUB00044093", "PUB00044094" ]

[ "12578822", "9786841", "1987644" ]

[ "Structural basis for DNA recognition by the basic region leucine zipper transcription factor CCAAT/enhancer-binding protein alpha.", "Biological role of the CCAAT/enhancer-binding protein family of transcription factors.", "CCAAT-enhancer binding protein: a component of a differentiation switch." ]

[ 2003, 1998, 1991 ]

3

[ "IPR031106" ]

[]

1

0

1

[ "Gnathostomata" ]

[ 1694 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 4, 10, 8 ]

4

true

Family

CCAAT/enhancer-binding protein, chordates

C/EBP_chordates

2

IPR016469

16,469

Carbohydrate sulfotransferase

Carbohydrate_sulfotransferase

Family

4,050

false

This entry represents carbohydrate sulphotransferase, which catalyses the transfer of a sulphate to position 6 of the galactose (Gal) residues in keratan. It may function in the sulphation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins and participate in the biosynthesis of selectin liga...

[ "GO:0008146", "GO:0005975", "GO:0000139" ]

[ "sulfotransferase activity", "carbohydrate metabolic process", "Golgi membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF005883" ]

[ "Carbohydrate_sulfotransferase" ]

[ 4050 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.8.2", "R-DRE-2022854", "R-HSA-2022854", "R-HSA-2022870", "R-HSA-3595172", "R-HSA-3656225", "R-HSA-913709", "R-MMU-2022854", "R-MMU-2022870", "R-MMU-913709", "R-RNO-2022854", "R-RNO-2022870" ]

[ "EC:2.8.2", "REACTOME:R-DRE-2022854", "REACTOME:R-HSA-2022854", "REACTOME:R-HSA-2022870", "REACTOME:R-HSA-3595172", "REACTOME:R-HSA-3656225", "REACTOME:R-HSA-913709", "REACTOME:R-MMU-2022854", "REACTOME:R-MMU-2022870", "REACTOME:R-MMU-913709", "REACTOME:R-RNO-2022854", "REACTOME:R-RNO-2022870"...

12

[]

0

[ "PUB00044060", "PUB00044061", "PUB00044062" ]

[ "11310842", "18513679", "11139648" ]

[ "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin.", "Congenital joint dislocations caused by carbohydrate sulfotransferase 3 deficiency in recessive Larsen syndrome and humero-spinal dysostosis.", "Mutations in corneal carbohyd...

[ 2001, 2008, 2000 ]

3

[]

0

null

[ "Vertebrata" ]

[ 4050 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 12, 9, 14 ]

4

true

Family

Carbohydrate sulfotransferase

Carbohydrate_sulfotransferase

3

IPR016470

16,470

Phycobilisome linker protein

Phycobilisome

Family

1,551

false

This group represents a phycobilisome rod linker polypeptide, phycocyanin-associated. They are linker polypeptides that determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and op...

[ "GO:0015979", "GO:0030089" ]

[ "photosynthesis", "phycobilisome" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF005898" ]

[ "Phycobilisome_CpeC/CpcI" ]

[ 1551 ]

1

[]

0

[ "5y6p", "6kgx", "7ext", "7eyd", "7ezx", "7sc7", "7sc8", "7sc9", "7sca", "7scb", "7scc", "7veb", "7y4l", "7y5e", "7y7a", "8hfq", "8to2", "8to5", "8tpj", "8tro", "8wql" ]

21

[ "PUB00074900", "PUB00074901" ]

[ "1694529", "1551428" ]

[ "Characterization of the light-regulated operon encoding the phycoerythrin-associated linker proteins from the cyanobacterium Fremyella diplosiphon.", "Three C-phycoerythrin-associated linker polypeptides in the phycobilisome of green-light-grown Calothrix sp. PCC 7601 (cyanobacteria)." ]

[ 1990, 1992 ]

2

[]

0

null

[ "Cyanobacteriota", "Eukaryota" ]

[ 1341, 210 ]

2

[]

0

true

Family

Phycobilisome linker protein

Phycobilisome

5

IPR016471

16,471

Nicotinamide phosphoribosyl transferase

Nicotinamide_PRibTrfase

Family

5,492

false

This entry represents the family of nicotinamide phosphoribosyl transferases (NAMPT). NAMPT consists of two intertwined α/β domains one of which is a rudiment of the classical TIM-barrel [ ]. It forms dimers that exist in a head to tail configuration. Nicotinamide phosphoribosyl transferase (NAMPT) catalyses the conden...

[]

0

[ "NCBIFAM", "PIRSF", "PANTHER", "CDD" ]

[ "NF006629", "PIRSF005943", "PTHR43816", "cd01569" ]

[ "PRK09198.1", "NMPRT", "", "PBEF_like" ]

[ 4752, 4249, 5489, 3583 ]

4

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.4.2.12", "R-HSA-1368108", "R-HSA-196807", "R-HSA-9768919", "R-MMU-196807", "R-RNO-196807", "R-SSC-196807" ]

[ "EC:2.4.2.12", "REACTOME:R-HSA-1368108", "REACTOME:R-HSA-196807", "REACTOME:R-HSA-9768919", "REACTOME:R-MMU-196807", "REACTOME:R-RNO-196807", "REACTOME:R-SSC-196807" ]

7

[ "2e5b", "2e5c", "2e5d", "2g95", "2g96", "2g97", "2gvg", "2gvj", "2gvl", "2h3b", "2h3d", "3dgr", "3dhd", "3dhf", "3dkj", "3dkl", "3g8e", "4jnm", "4jr5", "4kfn", "4kfo", "4kfp", "4l4l", "4l4m", "4lts", "4lv9", "4lva", "4lvb", "4lvd", "4lvf", "4lvg", "4lww"...

99

[ "PUB00059630", "PUB00076359", "PUB00076360" ]

[ "19819904", "19149599", "19109034" ]

[ "Structure and reaction mechanism of human nicotinamide phosphoribosyltransferase.", "Nicotinamide phosphoribosyltransferase (Nampt): a link between NAD biology, metabolism, and diseases.", "Nampt: linking NAD biology, metabolism and cancer." ]

[ 2010, 2009, 2009 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 23, 2162, 2665, 611, 31 ]

5

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 27, 2, 4 ]

4

true

Family

Nicotinamide phosphoribosyl transferase

Nicotinamide_PRibTrfase

2

IPR016472

16,472

Transcription regulator MJ0621

MJ0621

Family

154

false

This group is represented by predicted transcriptional regulator MJ0621 from Methanocaldococcus jannaschii.

[]

0

[ "PIRSF" ]

[ "PIRSF005978" ]

[ "HTH_MJ0621_prd" ]

[ 154 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriati", "ecological metagenomes" ]

[ 152, 2 ]

2

[]

0

true

Family

Transcription regulator MJ0621

MJ0621

1

IPR016473

16,473

Deoxycytidylate deaminase

dCMP_deaminase

Family

9,712

false

Deoxycytidylate deaminase ( ) (dCMP deaminase) hydrolyzes deoxycytidylate mono phosphate (dCMP) into deoxyuridine mono phosphate (dUMP), thus providing the nucleotide substrate for thymidylate synthase. The enzyme requires zinc for catalytic activity which is regulated by the ratio of dCTP to dTTP, both the end product...

[ "GO:0004132", "GO:0008270", "GO:0006220" ]

[ "dCMP deaminase activity", "zinc ion binding", "pyrimidine nucleotide metabolic process" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF006019" ]

[ "dCMP_deaminase" ]

[ 9712 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.5.4.12", "PWY-7210", "R-HSA-499943", "R-MMU-499943", "R-RNO-499943" ]

[ "EC:3.5.4.12", "METACYC:PWY-7210", "REACTOME:R-HSA-499943", "REACTOME:R-MMU-499943", "REACTOME:R-RNO-499943" ]

5

[ "1vq2", "2w4l", "4p9c", "4p9d", "4p9e", "7fh4", "7fh9" ]

7

[ "PUB00002807", "PUB00047647", "PUB00070796" ]

[ "8428902", "18255096", "7685356" ]

[ "T4-phage deoxycytidylate deaminase is a metalloprotein containing two zinc atoms per subunit.", "Crystal structures of Streptococcus mutans 2'-deoxycytidylate deaminase and its complex with substrate analog and allosteric regulator dCTP x Mg2+.", "Primary structure of human deoxycytidylate deaminase and overex...

[ 1993, 2008, 1993 ]

3

[ "IPR015517" ]

[]

1

0

1

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 280, 7537, 828, 786, 281 ]

5

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Zea mays" ]

[ 4, 2, 3, 1 ]

4

true

Family

Deoxycytidylate deaminase

dCMP_deaminase

8

IPR016475

16,475

Phosphate acetyltransferase, bacteria

P-Actrans_bac

Family

8,133

false

E. coli is able to metabolise excess acetate and even use it as sole carbon source. The enzymes involved are acetyl-CoA synthetase (Acs, non-reversible dissimilation) and the phosphotransacetylase-acetate kinase pathway (Pta-Ack), which is characterised by its reversibility [ ]. This entry represents phosphate acetyltr...

[ "GO:0008959" ]

[ "phosphate acetyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF006107" ]

[ "PhpActrans_proteobac" ]

[ 8133 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.3.1.8", "PWY-1281", "PWY-5482", "PWY-5485", "PWY-5497", "PWY-6637", "PWY-8086", "PWY-8377" ]

[ "EC:2.3.1.8", "METACYC:PWY-1281", "METACYC:PWY-5482", "METACYC:PWY-5485", "METACYC:PWY-5497", "METACYC:PWY-6637", "METACYC:PWY-8086", "METACYC:PWY-8377" ]

8

[]

0

[ "PUB00073616" ]

[ "19852855" ]

[ "An insight into the role of phosphotransacetylase (pta) and the acetate/acetyl-CoA node in Escherichia coli." ]

[ 2009 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 8078, 22, 33 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Phosphate acetyltransferase, bacteria

P-Actrans_bac

4

IPR016476

16,476

SH3 domain protein

SH3_dom_pro

Family

3,531

false

Members of this protein family have a signal peptide, a strongly conserved SH3 domain, a variable region, and then a C-terminal hydrophobic transmembrane α helix region.

[]

0

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF006158", "TIGR04211" ]

[ "UCP006158_SH3", "SH3_and_anchor" ]

[ 2746, 3531 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 3450, 4, 77 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

SH3 domain protein

SH3_dom_pro

1

IPR016477

16,477

Fructosamine/Ketosamine-3-kinase

Fructo-/Ketosamine-3-kinase

Family

15,874

false

Ketosamines derive from a non-enzymatic reaction between a sugar and a protein [ ]. Ketosamine-3-kinases (KT3K), of which fructosamine-3-kinase (FN3K) is the best-known example, catalyse the phosphorylation of the ketosamine moiety of glycated proteins. The instability of a phosphorylated ketosamine leads to its degrad...

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF03881", "PIRSF006221", "PTHR12149" ]

[ "Fructosamin_kin", "Ketosamine-3-kinase", "" ]

[ 15869, 12185, 15365 ]

3

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.7.1.-", "PWY-5129", "PWY-6322", "PWY-6369", "PWY-6626", "PWY-6682", "PWY-6955", "PWY-7077", "PWY-7321", "PWY-7740", "PWY-7769", "PWY-7886", "PWY-7948", "PWY-7975", "PWY-8129", "PWY-8324", "PWY-8367", "PWY-8392", "PWY-8393", "PWY-8394", "PWY-8402", "R-HSA-163841", "R-MM...

[ "EC:2.7.1.-", "METACYC:PWY-5129", "METACYC:PWY-6322", "METACYC:PWY-6369", "METACYC:PWY-6626", "METACYC:PWY-6682", "METACYC:PWY-6955", "METACYC:PWY-7077", "METACYC:PWY-7321", "METACYC:PWY-7740", "METACYC:PWY-7769", "METACYC:PWY-7886", "METACYC:PWY-7948", "METACYC:PWY-7975", "METACYC:PWY-8...

23

[ "3f7w", "3jr1", "6oid", "8ue1", "9cx8", "9cxm", "9cxn", "9cxo", "9cxv", "9cxw" ]

10

[ "PUB00008463", "PUB00010999", "PUB00035935", "PUB00035936" ]

[ "11016445", "214181", "3319287", "14633848" ]

[ "Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase.", "Distribution of adenosine 5'-triphosphate (ATP)-dependent hexose kinases in microorganisms.", "Fructosamine: structure, analysis, and clinical usefulness.", "A mammalian protein homologous to fructosamine-3-kinase i...

[ 2000, 1978, 1987, 2003 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "unclassified sequences" ]

[ 9016, 6642, 117, 99 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 6, 2, 1, 13, 5, 2, 1, 10, 8 ]

10

true

Family

Fructosamine/Ketosamine-3-kinase

Fructo-/Ketosamine-3-kinase

4

IPR016478

16,478

GTPase, MTG1

GTPase_MTG1

Family

10,046

false

This group represents GTPases that belong to MMR1/HSR1 GTP-binding protein family, MTG1 subfamily. This entry includes Mitochondrial GTPase MTG1 which is required for mitochondrial translation. It is probably involved in assembly of the large ribosomal subunit [ ]. This family also includes Ribosome biogenesis GTPase A...

[]

0

[ "PIRSF" ]

[ "PIRSF006230" ]

[ "MG442" ]

[ 10046 ]

1

[]

0

[ "1puj", "3cnl", "3cnn", "3cno", "6g0z", "6g12", "6g14", "6g15", "6ppk", "7aoi", "7o9k", "7o9m", "7pd3", "8pk0", "8qsj", "9bsl", "9bss", "9e9c", "9hcf", "9hcg", "9hch" ]

21

[ "PUB00045451", "PUB00056829", "PUB00070812" ]

[ "17613524", "12808030", "16390447" ]

[ "Isolation and characterization of a dominant negative mutant of Bacillus subtilis GTP-binding protein, YlqF, essential for biogenesis and maintenance of the 50 S ribosomal subunit.", "MTG1 codes for a conserved protein required for mitochondrial translation.", "The essential GTPase RbgA (YlqF) is required for ...

[ 2007, 2003, 2006 ]

3

[]

[ "IPR019991" ]

0

1

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 161, 7947, 1883, 55 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 1, 1, 1, 5, 1, 3, 1, 2 ]

8

true

Family

GTPase, MTG1

GTPase_MTG1

7

IPR016479

16,479

tRNA/rRNA methyltransferase, YfiF, predicted

YfiF_prd

Family

1,613

false

This group represents a predicted tRNA/rRNA methyltransferase, YfiF type.

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "NCBIFAM", "PIRSF" ]

[ "NF008117", "PIRSF006280" ]

[ "PRK10864.1", "YfiF_prd" ]

[ 1465, 1519 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

146

[]

0

[]

0

[ "IPR004441" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta" ]

[ 1609, 4 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

tRNA/rRNA methyltransferase, YfiF, predicted

YfiF_prd

1

IPR016480

16,480

Glucose translocase, bactoprenol-linked

Glc_translocase_bactprenl-link

Family

1,202

false

This group represents a group of bactoprenol-linked glucose translocases. GtrA and GtrB are responsible for O-antigen glucosylation in Shigella flexneri [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF006298" ]

[ "GtrA_prd" ]

[ 1202 ]

1

[]

0

[]

0

[ "PUB00082586" ]

[ "11283281" ]

[ "Type IV O antigen modification genes in the genome of Shigella flexneri NCTC 8296." ]

[ 2001 ]

1

[]

0

null

[ "Caudoviricetes", "Pseudomonadati", "bioreactor metagenome" ]

[ 11, 1190, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Glucose translocase, bactoprenol-linked

Glc_translocase_bactprenl-link

2

IPR016482

16,482

Protein transport protein SecG/Sec61-beta/Sbh

SecG/Sec61-beta/Sbh

Family

5,609

false

This family includes preprotein translocase subunit SecG, protein transport protein Sec61 subunit beta and Sbh1. A conserved heterotrimeric integral membrane protein complex--the Sec61 complex (eukaryotes) or SecY complex (prokaryotes)--forms a protein-conducting channel that allows polypeptides to be transferred acros...

[]

0

[ "PFAM" ]

[ "PF03911" ]

[ "Sec61_beta" ]

[ 5609 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CFA-9609523", "R-DDI-9609523", "R-HSA-1236974", "R-HSA-1799339", "R-HSA-9609523", "R-MMU-9609523", "R-SCE-9609523", "R-SPO-9609523" ]

[ "REACTOME:R-CFA-9609523", "REACTOME:R-DDI-9609523", "REACTOME:R-HSA-1236974", "REACTOME:R-HSA-1799339", "REACTOME:R-HSA-9609523", "REACTOME:R-MMU-9609523", "REACTOME:R-SCE-9609523", "REACTOME:R-SPO-9609523" ]

8

[ "1rh5", "1rhz", "2ww9", "2wwa", "2wwb", "2yxq", "2yxr", "3bo0", "3bo1", "3dkn", "4cg5", "4cg6", "4cg7", "4v4n", "4v7i", "5a6u", "6ftg", "6fti", "6ftj", "6n3q", "6nd1", "6r7q", "6w6l", "7aft", "7kah", "7kai", "7kaj", "7kak", "7kal", "7kam", "7kan", "7kao"...

60

[ "PUB00022601", "PUB00028068" ]

[ "14661030", "11597451" ]

[ "X-ray structure of a protein-conducting channel.", "The Sec protein-translocation pathway." ]

[ 2004, 2001 ]

2

[]

[ "IPR023531", "IPR030671" ]

0

2

0

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 840, 3, 4733, 33 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 1, 1, 1, 3, 2, 1, 10, 2, 2, 1, 14 ]

12

true

Family

Protein transport protein SecG/Sec61-beta/Sbh

SecG/Sec61-beta/Sbh

1

IPR016483

16,483

Uncharacterised conserved protein UCP006404, peptidase M50/CBS

UCP006404_Pept_M50_CBS

Family

5,386

false

This group represents an uncharacterised protein with peptidase M50 and CBS domains.

[]

0

[ "PIRSF" ]

[ "PIRSF006404" ]

[ "UCP006404_Pept_M50_CBS" ]

[ 5386 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Symbiodiniaceae", "metagenomes" ]

[ 661, 4667, 3, 55 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP006404, peptidase M50/CBS

UCP006404_Pept_M50_CBS

1

IPR016486

16,486

Uncharacterised conserved protein UCP006591, MJ1004 type

UCP006591_CBS

Family

79

false

This group represents an uncharacterised protein with CBS domain pair, MJ1004 type.

[]

0

[ "PIRSF" ]

[ "PIRSF006591" ]

[ "UCP006591_CBS_MJ1004" ]

[ 79 ]

1

[]

0

[ "6h1w" ]

1

[]

0

[]

0

null

[ "Methanomada group", "bioreactor metagenome" ]

[ 78, 1 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP006591, MJ1004 type

UCP006591_CBS

4

IPR016487

16,487

Sm-like protein Lsm6/SmF

Lsm6/sSmF

Family

8,431

false

Small nuclear ribonucleoproteins (snRNPs) are components of major and minor spliceosomes that play an important role in the splicing of cellular pre-mRNAs. snRNPs contain a common core, composed of seven Sm proteins bound to snRNA. Five small snRNPs (U1, U2, U4 and U5) share the Sm heptamer ring composed of SmB/B', SmD...

[ "GO:0000398" ]

[ "mRNA splicing, via spliceosome" ]

[ "biological_process" ]

1

[ "PANTHER" ]

[ "PTHR11021" ]

[ "" ]

[ 8431 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-111367", "R-BTA-191859", "R-BTA-72163", "R-BTA-72165", "R-BTA-73856", "R-BTA-77588", "R-CEL-111367", "R-CEL-191859", "R-CEL-72163", "R-CEL-72165", "R-CEL-73856", "R-CEL-77588", "R-DDI-111367", "R-DDI-430039", "R-DDI-72163", "R-DDI-73856", "R-DDI-77588", "R-DME-111367", "R-...

[ "REACTOME:R-BTA-111367", "REACTOME:R-BTA-191859", "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72165", "REACTOME:R-BTA-73856", "REACTOME:R-BTA-77588", "REACTOME:R-CEL-111367", "REACTOME:R-CEL-191859", "REACTOME:R-CEL-72163", "REACTOME:R-CEL-72165", "REACTOME:R-CEL-73856", "REACTOME:R-CEL-77588", ...

40

[ "1h64", "1i81", "1i8f", "1jbm", "1jri", "1lnx", "1loj", "1m8v", "1mgq", "1n9r", "1n9s", "3cw1", "3jb9", "3jcm", "3jcr", "3pgw", "3swn", "4c8q", "4c92", "4emk", "4f7u", "4m75", "4m77", "4m78", "4m7a", "4m7d", "4pjo", "4v98", "4wzj", "4xq3", "5gam", "5gan"...

152

[ "PUB00073458", "PUB00085093" ]

[ "24240276", "23620288" ]

[ "Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.", "Arabidopsis thaliana LSM proteins function in mRNA splicing and degradation." ]

[ 2014, 2013 ]

2

[]

[ "IPR034100" ]

0

1

0

[ "Archaea", "Candidatus Segetimicrobium genomatis", "Eukaryota", "ecological metagenomes" ]

[ 329, 1, 8083, 18 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 12, 2, 3, 2, 4, 6, 2, 13, 6, 2, 2, 12 ]

12

true

Family

Sm-like protein Lsm6/SmF

Lsm6/sSmF

4

IPR016489

16,489

BAPKO_0422-like

Family

243

false

This entry represents a group of proteins mainly found in Spirochaetota, including the outer member β-barrel protein BAPKO_0422 from Borrelia afzelii ( ), which was shown to bind human factor H, a regulator of complement activation [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF13161", "PIRSF006685" ]

[ "DUF3996", "UCP006685" ]

[ 243, 67 ]

2

[]

0

[]

0

[ "PUB00154879" ]

[ "26181365" ]

[ "The Borrelia afzelii outer membrane protein BAPKO_0422 binds human factor-H and is predicted to form a membrane-spanning β-barrel." ]

[ 2015 ]

1

[]

0

null

[ "Bacteria" ]

[ 243 ]

1

[]

0

true

Family

BAPKO_0422-like

1

IPR016490

16,490

Transcriptional regulator, HTH, AF0396-type

Tscrpt_reg_HTH_AF0396-typ3

Family

1,072

false

This group represents a predicted HTH transcriptional regulator, AF0396 type.

[]

0

[ "PIRSF" ]

[ "PIRSF006692" ]

[ "TF_HTH_AF0396_prd" ]

[ 1072 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 1063, 9 ]

2

[]

0

true

Family

Transcriptional regulator, HTH, AF0396-type

Tscrpt_reg_HTH_AF0396-typ3

5

IPR016491

16,491

Septin

Family

34,291

false

This entry represents various septin proteins. These proteins were initially described in yeast, where a cross wall (septum) is produced during cytokinesis and then splits in certain organisms to allow the daughter cells to separate [ ]. However, the septin family is now recognised to extend to mammals and is associate...

[ "GO:0005525" ]

[ "GTP binding" ]

[ "molecular_function" ]

1

[ "PIRSF", "CDD" ]

[ "PIRSF006698", "cd01850" ]

[ "Septin", "CDC_Septin" ]

[ 27456, 33571 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5620912", "R-HSA-111457", "R-HSA-111469", "R-HSA-5620912", "R-HSA-5687128", "R-MMU-111457", "R-MMU-111469", "R-MMU-5620912", "R-MMU-5687128", "R-RNO-111457", "R-RNO-111469", "R-RNO-5620912", "R-RNO-5687128", "R-SCE-111457", "R-SPO-111457", "R-SPO-111469" ]

[ "REACTOME:R-BTA-5620912", "REACTOME:R-HSA-111457", "REACTOME:R-HSA-111469", "REACTOME:R-HSA-5620912", "REACTOME:R-HSA-5687128", "REACTOME:R-MMU-111457", "REACTOME:R-MMU-111469", "REACTOME:R-MMU-5620912", "REACTOME:R-MMU-5687128", "REACTOME:R-RNO-111457", "REACTOME:R-RNO-111469", "REACTOME:R-RN...

16

[ "2qa5", "2qag", "2qnr", "3ftq", "3sop", "3t5d", "3tw4", "4kv9", "4kva", "4yqf", "4z51", "4z54", "5ar1", "5cyo", "5cyp", "6mq9", "6mqb", "6mqk", "6mql", "6n0b", "6n12", "6upa", "6upq", "6upr", "6uqq", "7m6j", "8dkt", "8fwp", "8pfh", "8sgd", "9bht", "9bhw"...

33

[ "PUB00013952", "PUB00019660", "PUB00042753", "PUB00042754", "PUB00042755", "PUB00080011", "PUB00080012", "PUB00080013", "PUB00085092" ]

[ "11916378", "12665577", "17596184", "17067846", "16207085", "12445407", "12888292", "12111093", "8181057" ]

[ "Classification and evolution of P-loop GTPases and related ATPases.", "Molecular dissection of a yeast septin: distinct domains are required for septin interaction, localization, and function.", "Splitting of the fission yeast septum.", "Septin localization across kingdoms: three themes with variations.", ...

[ 2002, 2003, 2007, 2006, 2005, 2002, 2003, 2002, 1994 ]

9

[]

[ "IPR008113", "IPR008114", "IPR008115" ]

0

3

0

[ "Eukaryota" ]

[ 34291 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 4, 81, 11, 86, 51, 5, 104, 7, 7 ]

9

true

Family

Septin

2

IPR016493

16,493

Spore coat protein CotF

Spore_coat_CotF

Family

69

false

The Coat F proteins contribute to the Bacillales spore coat. They occur multiple times in the genomes in which they are found. Bacillus subtilis endospore protein coats protect them and may play a role in their germination [ ]. Spore coat protein F, on the outer surface of the endospore, is one of a suite of proteins t...

[]

0

[ "PIRSF" ]

[ "PIRSF006716" ]

[ "Spore_coat_CotF" ]

[ 69 ]

1

[]

0

[]

0

[ "PUB00044606", "PUB00044607" ]

[ "18723620", "14711677" ]

[ "Characterization of spores of Bacillus subtilis that lack most coat layers.", "Species differentiation of a diverse suite of Bacillus spores by mass spectrometry-based protein profiling." ]

[ 2008, 2004 ]

2

[ "IPR012851" ]

[]

1

0

1

[ "Bacillales" ]

[ 69 ]

1

[]

0

true

Family

Spore coat protein CotF

Spore_coat_CotF

2

IPR016494

16,494

5'-3' exoribonuclease 1

5_3_exoribonuclease_1

Family

3,128

false

5'-3'-exoribonucleases are enzymes that degrade RNA by removing terminal nucleotides from the 5' end. 5'-3'exoribonuclease type 1 (Xrn1, also known as kem1) occurs in animal and fungal lineages. In Saccharomyces cerevisiae, Xrn1 can be activated by Dcs1, a non-essential hydrolase that involved in mRNA decapping. The ac...

[ "GO:0008409", "GO:0000956" ]

[ "5'-3' exonuclease activity", "nuclear-transcribed mRNA catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF006743" ]

[ "Exonuclease_Xnr1" ]

[ 3128 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.13.-", "R-HSA-430039", "R-HSA-450385", "R-HSA-450513", "R-MMU-450385", "R-MMU-450513" ]

[ "EC:3.1.13.-", "REACTOME:R-HSA-430039", "REACTOME:R-HSA-450385", "REACTOME:R-HSA-450513", "REACTOME:R-MMU-450385", "REACTOME:R-MMU-450513" ]

6

[ "2y35", "3pie", "3pif" ]

3

[ "PUB00063332" ]

[ "22570495" ]

[ "Activation of 5'-3' exoribonuclease Xrn1 by cofactor Dcs1 is essential for mitochondrial function in yeast." ]

[ 2012 ]

1

[ "IPR027073" ]

[]

1

0

1

[ "Eukaryota" ]

[ 3128 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 4, 3, 1, 3, 1, 3, 1, 1 ]

9

true

Family

5'-3' exoribonuclease 1

5_3_exoribonuclease_1

4

IPR016495

16,495

p53 negative regulator Mdm2/Mdm4

p53_neg-reg_MDM_2/4

Family

3,227

false

This group represents a p53 negative regulator Mdm2/Mdm4. MDM2 is an oncoprotein that acts as a cellular inhibitor of the p53 tumour suppressor by binding to the transactivation domain of p53 and suppressing its ability to activate transcription [ ]. In addition, MDM2 acts as an E3 ubiquitin ligase responsible for the ...

[ "GO:0043066", "GO:0051726", "GO:0005634" ]

[ "negative regulation of apoptotic process", "regulation of cell cycle", "nucleus" ]

[ "biological_process", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF006748" ]

[ "p53_MDM_2/4" ]

[ 3227 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CFA-2559580", "R-CFA-2559585", "R-CFA-399719", "R-CFA-5689880", "R-CFA-6804756", "R-CFA-6804757", "R-CFA-6804760", "R-CFA-69541", "R-CFA-8941858", "R-CFA-9766229", "R-DRE-198323", "R-DRE-2559580", "R-DRE-2559585", "R-DRE-3232142", "R-DRE-6804757", "R-DRE-69541", "R-DRE-8941858", ...

[ "REACTOME:R-CFA-2559580", "REACTOME:R-CFA-2559585", "REACTOME:R-CFA-399719", "REACTOME:R-CFA-5689880", "REACTOME:R-CFA-6804756", "REACTOME:R-CFA-6804757", "REACTOME:R-CFA-6804760", "REACTOME:R-CFA-69541", "REACTOME:R-CFA-8941858", "REACTOME:R-CFA-9766229", "REACTOME:R-DRE-198323", "REACTOME:R-...

53

[ "1rv1", "1t4e", "1t4f", "1ttv", "1ycq", "1ycr", "1z1m", "2axi", "2gv2", "2hdp", "2lzg", "2m86", "2mps", "2mwy", "2n06", "2n0u", "2n0w", "2n14", "2vje", "2vjf", "2vyr", "2z5s", "2z5t", "3dab", "3dac", "3eqs", "3eqy", "3fdo", "3fe7", "3fea", "3g03", "3iux"...

198

[ "PUB00013998", "PUB00034794" ]

[ "8875929", "14707282" ]

[ "Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.", "MDM2, an introduction." ]

[ 1996, 2003 ]

2

[]

[ "IPR015458", "IPR028340" ]

0

2

0

[ "Eumetazoa" ]

[ 3227 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 67, 11, 10 ]

4

true

Family

p53 negative regulator Mdm2/Mdm4

p53_neg-reg_MDM_2/4

3

IPR016496

16,496

GTPase HflX

GTPase_HflX

Family

29,610

false

This protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial family members are designated HflX, following the naming convention in Escherichia coli, where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of ...

[ "GO:0005525" ]

[ "GTP binding" ]

[ "molecular_function" ]

1

[ "HAMAP", "PIRSF", "PANTHER", "NCBIFAM" ]

[ "MF_00900", "PIRSF006809", "PTHR10229", "TIGR03156" ]

[ "GTPase_HflX", "GTP-binding_hflX_prd", "", "GTP_HflX" ]

[ 26021, 23883, 29593, 27978 ]

4

[]

0

[ "2qtf", "2qth", "3kxi", "3kxk", "3kxl", "5ady", "5zzm", "7of2", "7of4", "7of6", "7yla", "8a57", "8g31", "8g34", "8g38", "8kab", "8uu7", "8uu8", "8uu9", "8uua", "8vio", "8vk0", "8vk7", "8vki", "8vkw", "8vpk", "8vr4", "8vr8", "8vrl" ]

29

[ "PUB00043068", "PUB00043069", "PUB00056839", "PUB00056840", "PUB00056841" ]

[ "8248183", "9466997", "21478358", "18957606", "19787775" ]

[ "The Escherichia coli hflA locus encodes a putative GTP-binding protein and two membrane proteins, one of which contains a protease-like domain.", "A novel pseudoautosomal gene encoding a putative GTP-binding protein resides in the vicinity of the Xp/Yp telomere.", "An HflX-type GTPase from Sulfolobus solfatari...

[ 1993, 1998, 2011, 2008, 2010 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 818, 24675, 3500, 617 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 9, 1, 2, 2, 1, 4, 5, 9, 5, 24 ]

10

true

Family

GTPase HflX

GTPase_HflX

4

IPR016497

16,497

Herpesvirus UL5

Herpes_UL5

Family

38

false

This group represents an uncharacterised conserved protein UL5.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27693", "PIRSF006846" ]

[ "Herpes_UL5", "UCP006846_UL5" ]

[ 38, 38 ]

2

[ "REACTOME" ]

[ "R-HSA-9609690" ]

[ "REACTOME:R-HSA-9609690" ]

1

[]

0

[]

0

[]

0

null

[ "Cytomegalovirus" ]

[ 38 ]

1

[]

0

true

Family

Herpesvirus UL5

Herpes_UL5

6

IPR016498

16,498

Protein YzcX

YzcX

Family

6

false

The function of YzcX (also known as CyaX) is not clear [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF006864" ]

[ "UCP006864" ]

[ 6 ]

1

[]

0

[]

0

[ "PUB00092453" ]

[ "6393056" ]

[ "The complete nucleotide sequence of the adenylate cyclase gene of Escherichia coli." ]

[ 1984 ]

1

[]

0

null

[ "Enterobacteriaceae" ]

[ 6 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Protein YzcX

YzcX

7

IPR016499

16,499

Nucleic acid binding protein, Rv2694c, predicted

NucleicA-bd_Rv2694c_prd

Family

2,474

false

This group represents a predicted nucleic acid binding protein, Rv2694c type.

[]

0

[ "PIRSF" ]

[ "PIRSF006910" ]

[ "NA_bind_Rv2694c_prd" ]

[ 2474 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes", "ecological metagenomes" ]

[ 2466, 8 ]

2

[]

0

true

Family

Nucleic acid binding protein, Rv2694c, predicted

NucleicA-bd_Rv2694c_prd

8

IPR016500

16,500

Uncharacterised conserved protein UCP006993

UCP006993

Family

750

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. However, they possess a predicted signal peptide.

[]

0

[ "PIRSF" ]

[ "PIRSF006993" ]

[ "UCP006993" ]

[ 750 ]

1

[]

0

[]

0

[]

0

[ "IPR010858" ]

[]

1

0

1

[ "Gammaproteobacteria", "bioreactor metagenome" ]

[ 749, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Uncharacterised conserved protein UCP006993

UCP006993

8

IPR016502

16,502

Type II secretion system (T2SS) pilotin, S protein

T2SSS_2

Family

464

false

This entry represents pilotin AspS from Vibrio and some E.coli and Shigella. This entry also includes YghG from E. coli. AspS is part of the Vibrio-type T2SS secretin system that drives the secretion of fully-folded protein substrates across the bacterial outer membrane. The structure of AspS has been revealed [ , ]. T...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF16549", "PIRSF007010" ]

[ "T2SSS_2", "UCP007010" ]

[ 464, 312 ]

2

[ "REACTOME" ]

[ "R-HSA-9760173" ]

[ "REACTOME:R-HSA-9760173" ]

1

[ "4ftf", "5zdh", "6i2v" ]

3

[ "PUB00051842", "PUB00076276", "PUB00092773", "PUB00093998", "PUB00094002", "PUB00094004" ]

[ "19217396", "23326233", "29632366", "30767847", "28258547", "22523076" ]

[ "Crystal structure of the N-terminal domain of the secretin GspD from ETEC determined with the assistance of a nanobody.", "Assembly of the type II secretion system such as found in Vibrio cholerae depends on the novel Pilotin AspS.", "Structural insight into the assembly of the type II secretion system pilotin...

[ 2009, 2013, 2018, 2019, 2017, 2012 ]

6

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 463, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Type II secretion system (T2SS) pilotin, S protein

T2SSS_2

9

IPR016504

16,504

Outer membrane protein YaiO

YaiO

Family

97

false

This entry represents a group of proteins including the outer membrane protein YaiO from E. coli [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF007027" ]

[ "UCP007027" ]

[ 97 ]

1

[]

0

[]

0

[ "PUB00060465" ]

[ "16522795" ]

[ "New Escherichia coli outer membrane proteins identified through prediction and experimental verification." ]

[ 2006 ]

1

[]

0

null

[ "Enterobacteriaceae" ]

[ 97 ]

1

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Outer membrane protein YaiO

YaiO

5

IPR016505

16,505

Protein YopQ

YopQ

Family

15

false

Salmonella, and related proteobacteria, secrete large amounts of proteins into the culture media. The major secreted proteins are either flagellar proteins or virulence factors [ ], secreted through the flagellar or virulence export structures respectively. Both secretion systems penetrate the inner and outer membranes...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27699", "PIRSF007043" ]

[ "YopQ", "T3SS_YopQ" ]

[ 15, 14 ]

2

[]

0

[ "8brf" ]

1

[ "PUB00007583", "PUB00020767", "PUB00054227", "PUB00100143", "PUB00100144" ]

[ "10564516", "11844757", "9554854", "2129533", "11988520" ]

[ "Flagellar proteins and type III-exported virulence factors are the predominant proteins secreted into the culture media of Salmonella typhimurium.", "YopD and LcrH regulate expression of Yersinia enterocolitica YopQ by a posttranscriptional mechanism and bind to yopQ RNA.", "Supramolecular structure of the Sal...

[ 1999, 2002, 1998, 1990, 2002 ]

5

[]

0

null

[ "Bacteria" ]

[ 15 ]

1

[]

0

true

Family

Protein YopQ

YopQ

7

IPR016506

16,506

Competence protein D, Pasteurellaceae

ComD_Pasteurellaceae

Family

30

false

Competence is the ability of a cell to take up exogenous DNA from its environment, resulting in transformation. It is widespread among bacteria and is probably an important mechanism for the horizontal transfer of genes. DNA usually becomes available by the death and lysis of other cells. Competent bacteria use compone...

[]

0

[ "PIRSF" ]

[ "PIRSF007059" ]

[ "ComD" ]

[ 30 ]

1

[]

0

[]

0

[ "PUB00052316" ]

[ "8901420" ]

[ "Who's competent and when: regulation of natural genetic competence in bacteria." ]

[ 1996 ]

1

[ "IPR007446" ]

[]

1

0

1

[ "Pasteurellaceae" ]

[ 30 ]

1

[]

0

true

Family

Competence protein D, Pasteurellaceae

ComD_Pasteurellaceae

8

IPR016507

16,507

Uncharacterised conserved protein UCP007061

UCP007061

Family

50

false

This group represents a uncharacterised conserved proteins from enterobacteriaceae.

[]

0

[ "PIRSF" ]

[ "PIRSF007061" ]

[ "UCP007061" ]

[ 50 ]

1

[]

0

[]

0

[]

0

[ "IPR007922" ]

[]

1

0

1

[ "Rickettsiaceae" ]

[ 50 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP007061

UCP007061

8

IPR016510

16,510

Cysteine protease S273R

VPRT

Family

23

false

This group represents a group of proteins predominantly found in African swine fever virus (ASVF), including Cysteine protease S273R (VPRT). This enzyme catalyses the maturation of the pp220 and pp62 polyprotein precursors into core-shell proteins [ , ]. Cysteine peptidases with a chymotrypsin-like fold are included in...

[ "GO:0004197", "GO:0019082" ]

[ "cysteine-type endopeptidase activity", "viral protein processing" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF007159" ]

[ "Peptidase_ASVF" ]

[ 23 ]

1

[ "EC" ]

[ "3.4.22.-" ]

[ "EC:3.4.22.-" ]

1

[ "6lj9", "6ljb" ]

2

[ "PUB00011704", "PUB00020025", "PUB00030423", "PUB00076953", "PUB00100347", "PUB00100348" ]

[ "11517925", "9891971", "14725770", "7044372", "11031264", "12719549" ]

[ "Evolutionary lines of cysteine peptidases.", "Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.", "The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall.", ...

[ 2001, 1998, 2004, 1982, 2001, 2003 ]

6

[]

0

null

[ "Nucleocytoviricota" ]

[ 23 ]

1

[]

0

true

Family

Cysteine protease S273R

VPRT

5

IPR016511

16,511

Uncharacterised conserved protein UCP007248

UCP007248

Family

185

false

This group represents a uncharacterised conserved proteins from enterobacteriaceae.

[]

0

[ "PIRSF" ]

[ "PIRSF007248" ]

[ "UCP007248" ]

[ 185 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Campylobacterales" ]

[ 185 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP007248

UCP007248

7

IPR016512

16,512

Inner membrane YidI, enterobacteriaceae

IM_YidI_en

Family

95

false

This group represents an inner membrane protein YidI in enterobacteriaceae.

[]

0

[ "PIRSF" ]

[ "PIRSF007312" ]

[ "Inner_membrane_protein_YidI" ]

[ 95 ]

1

[]

0

[]

0

[]

0

[ "IPR060044" ]

[]

1

0

1

[ "Enterobacteriaceae", "Trichuris trichiura" ]

[ 94, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Inner membrane YidI, enterobacteriaceae

IM_YidI_en

4

IPR016514

16,514

Fimbrial protein EcpA

EcpA

Family

405

false

This group represents the fimbrillin protein MatB [ ]. It is also known as EcpA, and is part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP), an adhesive structure produced by all E. coli pathogroups [ ] and plays a dual role in early-stage biofilm development and host cell recognition [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF16449", "PIRSF007320" ]

[ "MatB", "Fimbrillin_MatB" ]

[ 405, 149 ]

2

[]

0

[ "3qs2", "3qs3" ]

2

[ "PUB00042865", "PUB00076264", "PUB00097427" ]

[ "11466275", "23302788", "22355107" ]

[ "matB, a common fimbrillin gene of Escherichia coli, expressed in a genetically conserved, virulent clonal group.", "Multi-functional analysis of Klebsiella pneumoniae fimbrial types in adherence and biofilm formation.", "Structural insights into the biogenesis and biofilm formation by the Escherichia coli comm...

[ 2001, 2013, 2012 ]

3

[]

0

null

[ "Pseudomonadota", "Thelohanellus kitauei" ]

[ 404, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Fimbrial protein EcpA

EcpA

4

IPR016515

16,515

Uncharacterised conserved protein UCP007407, Abi protease-like

UCP007407_Abi-like

Family

6

false

This group represents an uncharacterised protein with Abi protease domain.

[]

0

[ "PIRSF" ]

[ "PIRSF007407" ]

[ "UCP007407_Abi-like" ]

[ 6 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanophyceae" ]

[ 6 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP007407, Abi protease-like

UCP007407_Abi-like

7

IPR016516

16,516

Uncharacterised conserved protein UCP07580

UCP07580

Family

7,734

false

This entry represents a group of uncharacterised bacterial proteins. Many members of this family are predicted to be metal-dependent hydrolases.

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF10118", "PIRSF007580", "PTHR39456" ]

[ "Metal_hydrol", "UCP07580", "" ]

[ 7729, 6683, 7685 ]

3

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes", "uncultured Caudovirales phage" ]

[ 7681, 13, 39, 1 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP07580

UCP07580

2

IPR016517

16,517

Peptidase M11, autolysin

Peptidase_M11_autolysin

Family

9

false

Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase...

[]

0

[ "PIRSF" ]

[ "PIRSF007635" ]

[ "Autolysin" ]

[ 9 ]

1

[]

0

[]

0

[ "PUB00003579" ]

[ "7674922" ]

[ "Evolutionary families of metallopeptidases." ]

[ 1995 ]

1

[]

0

null

[ "Chlamydomonas" ]

[ 9 ]

1

[]

0

true

Family

Peptidase M11, autolysin

Peptidase_M11_autolysin

6

IPR016520

16,520

Uncharacterised conserved protein UCP007778

UCP007778

Family

27

false

This group represents a uncharacterised conserved proteins from enterobacteriaceae.

[]

0

[ "PIRSF" ]

[ "PIRSF007778" ]

[ "UCP007778" ]

[ 27 ]

1

[]

0

[]

0

[]

0

[ "IPR060045" ]

[]

1

0

1

[ "Saccharomycotina" ]

[ 27 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Uncharacterised conserved protein UCP007778

UCP007778

3

IPR016521

16,521

RNA-processing, Lsm12

RNA-processing_Lsm12

Family

120

false

Sm and Sm-like proteins of the Lsm (like Sm) domain family are generally involved in essential RNA-processing tasks [ ]. All the LSM proteins are evolutionarily conserved in eukaryotes with an N-terminal Lsm domain to bind nucleic acids followed by as yet uncharacterised C-terminal region, some of which have a C-termin...

[]

0

[ "PIRSF" ]

[ "PIRSF007783" ]

[ "UCP007783_YHR121w" ]

[ 120 ]

1

[]

0

[]

0

[ "PUB00016606", "PUB00044226" ]

[ "10801455", "15225602" ]

[ "Functions of Lsm proteins in mRNA degradation and splicing.", "Novel Sm-like proteins with long C-terminal tails and associated methyltransferases." ]

[ 2000, 2004 ]

2

[ "IPR039683" ]

[]

1

0

1

[ "Opisthokonta" ]

[ 120 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

RNA-processing, Lsm12

RNA-processing_Lsm12

6

IPR016522

16,522

Ribosome assembly protein RSM22, mitochondrial, budding yeast

RSM22_mit_bud

Family

210

false

This group represents Ribosome assembly protein RSM22 from Saccharomyces cerevisiae and similar sequences predominantly found in Saccharomycetales (budding yeasts). RSM22 is a mitochondrial ribosome (mitoribosome) assembly factor that binds at the interface of the head and body domains of the mitochondrial small riboso...

[]

0

[ "PIRSF" ]

[ "PIRSF007797" ]

[ "RSM22" ]

[ 210 ]

1

[]

0

[ "8d8j", "8d8k", "8d8l", "8om2" ]

4

[ "PUB00150960", "PUB00153722" ]

[ "36482135", "38199006" ]

[ "Principles of mitoribosomal small subunit assembly in eukaryotes.", "METTL17 is an Fe-S cluster checkpoint for mitochondrial translation." ]

[ 2023, 2024 ]

2

[ "IPR015324" ]

[]

1

0

1

[ "Fungi" ]

[ 210 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Ribosome assembly protein RSM22, mitochondrial, budding yeast

RSM22_mit_bud

2

IPR016523

16,523

Calcipressin-like protein

Rcn1_fungi

Family

20

false

This entry represents calcipressin-like protein Rcn1 from fungi. Rcn1 is involved in calcineurin regulation during calcium signalling [ ].

[ "GO:0019722" ]

[ "calcium-mediated signaling" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF007798" ]

[ "UCP007798" ]

[ 20 ]

1

[]

0

[]

0

[ "PUB00074945" ]

[ "10887154" ]

[ "A conserved family of calcineurin regulators." ]

[ 2000 ]

1

[ "IPR006931" ]

[]

1

0

1

[ "Saccharomycotina" ]

[ 20 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Calcipressin-like protein

Rcn1_fungi

8

IPR016524

16,524

Ubiquitin-like-conjugating enzyme Atg10

Atg10

Family

12

false

Atg10 is an E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. It catalyses the conjugation of Atg12 to Atg5, which is required for proper localisation of Atg8 to the preautophagosomal structure (PAS) [ ].

[ "GO:0019777", "GO:0006914" ]

[ "Atg12 transferase activity", "autophagy" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF007802" ]

[ "Autophagy-rel_ATG10" ]

[ 12 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.3.2.-", "PWY-6289", "PWY-6462", "PWY-6463", "PWY-6682", "PWY-6841", "PWY-7815", "PWY-7816", "PWY-7817", "PWY-7818", "PWY-7887" ]

[ "EC:2.3.2.-", "METACYC:PWY-6289", "METACYC:PWY-6462", "METACYC:PWY-6463", "METACYC:PWY-6682", "METACYC:PWY-6841", "METACYC:PWY-7815", "METACYC:PWY-7816", "METACYC:PWY-7817", "METACYC:PWY-7818", "METACYC:PWY-7887" ]

11

[ "4ebr", "4gsk" ]

2

[ "PUB00074946" ]

[ "10508157" ]

[ "Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast." ]

[ 1999 ]

1

[]

0

null

[ "Saccharomycetaceae" ]

[ 12 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Ubiquitin-like-conjugating enzyme Atg10

Atg10

1

IPR016527

16,527

Origin recognition complex subunit 4

ORC4

Family

4,698

false

The Origin Recognition Complex (ORC) is a six-subunit ATP-dependent DNA-binding complex encoded by ORC1-6 [ ]. ORC is a central component for eukaryotic DNA replication, and binds chromatin at replication origins throughout the cell cycle [ ]. ORC directs DNA replication throughout the genome and is required for its in...

[ "GO:0003677", "GO:0006260", "GO:0000808", "GO:0005634" ]

[ "DNA binding", "DNA replication", "origin recognition complex", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PIRSF", "PANTHER" ]

[ "PIRSF007858", "PTHR12087" ]

[ "ORC4", "" ]

[ 2131, 4698 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-176187", "R-BTA-68616", "R-BTA-68689", "R-BTA-68949", "R-BTA-68962", "R-DDI-68616", "R-DDI-68689", "R-DDI-68962", "R-HSA-113507", "R-HSA-176187", "R-HSA-68616", "R-HSA-68689", "R-HSA-68867", "R-HSA-68949", "R-HSA-68962", "R-MMU-176187", "R-MMU-68616", "R-MMU-68689", "R-MMU...

[ "REACTOME:R-BTA-176187", "REACTOME:R-BTA-68616", "REACTOME:R-BTA-68689", "REACTOME:R-BTA-68949", "REACTOME:R-BTA-68962", "REACTOME:R-DDI-68616", "REACTOME:R-DDI-68689", "REACTOME:R-DDI-68962", "REACTOME:R-HSA-113507", "REACTOME:R-HSA-176187", "REACTOME:R-HSA-68616", "REACTOME:R-HSA-68689", "...

34

[ "4xgc", "5uj7", "5ujm", "5v8f", "5zr1", "6rqc", "6wgc", "6wgg", "6wgi", "7cte", "7ctf", "7ctg", "7jgr", "7jgs", "7jk2", "7jk3", "7jk4", "7jk5", "7jk6", "7jpo", "7jpp", "7jpq", "7jpr", "7jps", "7mca", "7tjf", "7tjh", "7tji", "7tjj", "7tjk", "8rwv", "8s0c"...

43

[ "PUB00052559", "PUB00052560", "PUB00052561", "PUB00052562", "PUB00052563", "PUB00052564", "PUB00052565", "PUB00052566", "PUB00052567", "PUB00052568", "PUB00052569", "PUB00052570", "PUB00052571", "PUB00052572", "PUB00052573", "PUB00052574", "PUB00052575", "PUB00052576", "PUB000525...

[ "17241905", "17825065", "1579162", "7585959", "16716188", "7892251", "7781615", "16228006", "10966477", "12045100", "15680967", "11572976", "11429609", "16024805", "8622770", "9171055", "9038340", "11459976", "15610739", "16387651", "17053779", "9442876", "31160578", "3...

[ "Multiple functions of the origin recognition complex.", "Yeast two-hybrid analysis of the origin recognition complex of Saccharomyces cerevisiae: interaction between subunits and identification of binding proteins.", "ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex....

[ 2007, 2007, 1992, 1995, 2006, 1995, 1995, 2005, 2000, 2002, 2005, 2001, 2001, 2005, 1996, 1997, 1997, 2001, 2004, 2006, 2006, 1997, 2019, 2020 ]

24

[]

0

null

[ "Eukaryota" ]

[ 4698 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 2, 2, 2, 9, 7, 1, 2, 6, 1, 1, 13 ]

12

true

Family

Origin recognition complex subunit 4

ORC4

3

IPR016530

16,530

Mediator of RNA polymerase II transcription subunit 22, Saccharomycetes

Med22_Saccharomyce

Family

57

false

This entry represents the Med22 subunit of the Mediator complex in Saccharomycetaceae. The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal R...

[ "GO:0003712", "GO:0006357", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of transcription by RNA polymerase II", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF007936" ]

[ "SRB6" ]

[ 57 ]

1

[]

0

[ "3j1o", "3r84", "3rj1", "4gwp", "4gwq", "4v1o", "5oqm", "5sva", "7ui9", "7uif", "7uig", "7uio", "8cen", "8ceo" ]

14

[]

0

[ "IPR009332" ]

[]

1

0

1

[ "Saccharomycetaceae" ]

[ 57 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Mediator of RNA polymerase II transcription subunit 22, Saccharomycetes

Med22_Saccharomyce

6

IPR016531

16,531

RNA polymerase I-specific transcription initiation factor Rrn6

Rrn6

Family

16

false

Rrn6 is a component of the core factor (CF) rDNA transcription factor complex (consists of Rrn6, Rrn7 and Rrn11), which is required for transcription of 35S rRNA genes by RNA polymerase I [ , ].

[ "GO:0006361", "GO:0070860" ]

[ "transcription initiation at RNA polymerase I promoter", "RNA polymerase I core factor complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF007939" ]

[ "RNA_pol_I_RRN6" ]

[ 16 ]

1

[]

0

[ "5n5y", "5n5z", "5n60", "5n61", "5o7x", "5oa1", "5w5y", "5w64", "5w65", "5w66", "6rqh", "6rql", "6rrd", "6rui", "6ruo", "6rwe" ]

16

[ "PUB00044475", "PUB00099775" ]

[ "7958901", "28340337" ]

[ "RRN6 and RRN7 encode subunits of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae.", "Structural Basis of RNA Polymerase I Transcription Initiation." ]

[ 1994, 2017 ]

2

[ "IPR019350" ]

[]

1

0

1

[ "Saccharomycotina" ]

[ 16 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

RNA polymerase I-specific transcription initiation factor Rrn6

Rrn6

9

IPR016532

16,532

Mediator of RNA polymerase II transcription subunit 20

Med20

Family

22

false

The Mediator complex is a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact confor...

[ "GO:0003712", "GO:0006357", "GO:0016592" ]

[ "transcription coregulator activity", "regulation of transcription by RNA polymerase II", "mediator complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF007945" ]

[ "SRB2" ]

[ 22 ]

1

[]

0

[ "2hzm", "2hzs", "3j1o", "3rj1", "4gwp", "4gwq", "4v1o", "5oqm", "5sva", "7ui9", "7uif", "7uig", "7uio", "8cen", "8ceo" ]

15

[]

0

[ "IPR013921" ]

[]

1

0

1

[ "Saccharomycotina" ]

[ 22 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Mediator of RNA polymerase II transcription subunit 20

Med20

6

IPR016533

16,533

Wound-induced protein 1/12, subgroup

Wound-induced_1/12_sub

Family

247

false

This group represents wound-induced protein 1 (Wun1) [ ], and wound-induced protein 12 [ ] (also known as senescence associated gene 20).

[]

0

[ "PIRSF" ]

[ "PIRSF007948" ]

[ "Wound-induced_Wun1" ]

[ 247 ]

1

[]

0

[]

0

[ "PUB00085124", "PUB00085178" ]

[ "2615766", "12857840" ]

[ "Nucleotide sequence and regulated expression of a wound-inducible potato gene (wun1).", "Altered gene expression in three plant species in response to treatment with Nep1, a fungal protein that causes necrosis." ]

[ 1989, 2003 ]

2

[ "IPR009798" ]

[]

1

0

1

[ "Mesangiospermae" ]

[ 247 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 4, 1 ]

3

true

Family

Wound-induced protein 1/12, subgroup

Wound-induced_1/12_sub

8

IPR016534

16,534

Vacuolar protein sorting-associated protein 16

VPS16

Family

5,687

false

This group represents a vacuolar protein sorting-associated protein 16 (Vps16). Vps16 may play a role in vesicle-mediated protein trafficking to endosomal/lysosomal compartments and in membrane docking/fusion reactions [ , , ].

[ "GO:0006886", "GO:0007033" ]

[ "intracellular protein transport", "vacuole organization" ]

[ "biological_process", "biological_process" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF007949", "PTHR12811" ]

[ "VPS16", "" ]

[ 4251, 5687 ]

2

[ "REACTOME" ]

[ "R-HSA-9754560" ]

[ "REACTOME:R-HSA-9754560" ]

1

[ "4bx9", "4kmo", "5buz", "5bv0", "5bv1", "7zu0", "8dit", "8qx8" ]

8

[ "PUB00062953", "PUB00062954", "PUB00062955" ]

[ "11250079", "16601699", "15843430" ]

[ "Molecular cloning and characterization of human VPS18, VPS 11, VPS16, and VPS33.", "Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p.", "Genetic analysis of lysosomal trafficking in Caenorhabditis elegans." ]

[ 2001, 2006, 2005 ]

3

[]

0

null

[ "Eukaryota" ]

[ 5687 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 2, 5, 5, 1, 4, 7, 1, 1, 5 ]

12

true

Family

Vacuolar protein sorting-associated protein 16

VPS16

8

IPR016535

16,535

RFamide neuropeptide, ACEP-1

RFamide_neuropeptide_ACEP-1

Family

4

false

This entry represents ACEP-1 (Achatina cardioexcitatory peptide-1) type RFamide neuropeptides [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF008109" ]

[ "RFamide_neuropeptide_ACEP-1" ]

[ 4 ]

1

[]

0

[]

0

[ "PUB00042681" ]

[ "10612443" ]

[ "Characterization of cDNA and expression of mRNA encoding an Achatina cardioexcitatory RFamide peptide." ]

[ 1999 ]

1

[]

0

null

[ "Euthyneura" ]

[ 4 ]

1

[]

0

true

Family

RFamide neuropeptide, ACEP-1

RFamide_neuropeptide_ACEP-1

4

IPR016537

16,537

Uncharacterised conserved protein UCP008159, ABC-type

UCP008159_ABC

Family

2,154

false

This group represents a predicted uncharacterised ABC-type transport system, periplasmic component.

[]

0

[ "PIRSF" ]

[ "PIRSF008159" ]

[ "UCP008159_ABC" ]

[ 2154 ]

1

[]

0

[]

0

[]

0

[ "IPR010412" ]

[]

1

0

1

[ "Bacteria", "ecological metagenomes" ]

[ 2152, 2 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP008159, ABC-type

UCP008159_ABC

9

IPR016538

16,538

Uncharacterised conserved protein UCP008292

UCP008292

Family

1,686

false

This group represents an uncharacterised protein with calcineurin-like phosphoesterase domain.

[]

0

[ "PIRSF" ]

[ "PIRSF008292" ]

[ "UCP008292" ]

[ 1686 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 49, 1635, 2 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP008292

UCP008292

8

IPR016539

16,539

Uncharacterised conserved protein UCP008315

UCP008315

Family

28

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27703", "PIRSF008315" ]

[ "UCP008315", "UCP008315" ]

[ 28, 19 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Thermococcaceae" ]

[ 28 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP008315

UCP008315

4

IPR016540

16,540

Uncharacterised conserved protein UCP008459

UCP008459

Family

1,822

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF008459" ]

[ "UCP008459" ]

[ 1822 ]

1

[]

0

[ "1zhv" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 85, 1557, 145, 35 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP008459

UCP008459

7

IPR016541

16,541

Uncharacterised conserved protein UCP008505

UCP008505

Family

1,510

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF14367", "PIRSF008505" ]

[ "DUF4411", "UCP008505" ]

[ 1510, 470 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriati", "Siphoviridae sp. ctPyh10", "unclassified sequences" ]

[ 1424, 38, 1, 47 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP008505

UCP008505

1

IPR016542

16,542

Phosphatidylinositol N-acetylglucosaminyltransferase, GPI19/PIG-P subunit

PIG-P_GPI19

Family

1,222

false

This entry represents the phosphatidylinositol N-acetylglucosaminyltransferase GPI19/PIG-P subunit. These proteins form part of the complex catalysing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis [ ].

[ "GO:0017176", "GO:0006506" ]

[ "phosphatidylinositol N-acetylglucosaminyltransferase activity", "GPI anchor biosynthetic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF008765" ]

[ "PIG-P_GPI19" ]

[ 1222 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-162710", "R-MMU-162710" ]

[ "REACTOME:R-HSA-162710", "REACTOME:R-MMU-162710" ]

2

[]

0

[ "PUB00073477" ]

[ "16278447" ]

[ "Gpi19, the Saccharomyces cerevisiae homologue of mammalian PIG-P, is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1222 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 5, 1, 1, 2, 2, 1 ]

6

true

Family

Phosphatidylinositol N-acetylglucosaminyltransferase, GPI19/PIG-P subunit

PIG-P_GPI19

9

IPR016543

16,543

Mitochondria fission 1 protein

Fis1

Family

4,617

false

Fis1 is an outer mitochondrial membrane protein that plays a role in mitochondrial membrane fission [ , ]. In Saccharomyces cerevisiae, it facilitates mitochondrial fission by forming protein complexes with Dnm1 and Mdv1 [ ]. It contains tetratrico-peptide repeat (TPR)-like domain and a C-terminal transmembrane region ...

[ "GO:0000266" ]

[ "mitochondrial fission" ]

[ "biological_process" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF008835", "PTHR13247" ]

[ "TPR_repeat_11_Fis1", "" ]

[ 3459, 4617 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9603798", "R-CEL-9603798", "R-DME-9603798", "R-HSA-9603798", "R-MMU-9603798", "R-RNO-9603798", "R-SCE-9603798", "R-SPO-9603798" ]

[ "REACTOME:R-BTA-9603798", "REACTOME:R-CEL-9603798", "REACTOME:R-DME-9603798", "REACTOME:R-HSA-9603798", "REACTOME:R-MMU-9603798", "REACTOME:R-RNO-9603798", "REACTOME:R-SCE-9603798", "REACTOME:R-SPO-9603798" ]

8

[ "1iyg", "1nzn", "1pc2", "1y8m", "2pqn", "2pqr", "3o48", "3uux", "7ya9", "7yka", "8u1z", "8xwx", "9avb", "9avc", "9avd", "9ave", "9ayd", "9aye" ]

18

[ "PUB00022424", "PUB00029287", "PUB00067489", "PUB00067491", "PUB00103638" ]

[ "14623186", "14705031", "11038183", "16968746", "24196833" ]

[ "The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle.", "Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR fold.", "Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component ...

[ 2003, 2004, 2000, 2006, 2014 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4617 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 2, 1, 1, 1, 3, 1, 8, 3, 1, 1, 7 ]

12

true

Family

Mitochondria fission 1 protein

Fis1

9

IPR016544

16,544

N-glycosylase/DNA lyase

AGOG

Family

84

false

Oxidative damage represents a major threat to genomic stability, as the major product of DNA oxidation, 8-oxoguanine (GO), frequently mispairs with adenine during replication. In order to prevent these mutagenic events, organisms have evolved GO-DNA glycosylases (or N-glycosylase/DNA lyases) that remove this oxidized b...

[ "GO:0000702", "GO:0003906", "GO:0006284" ]

[ "oxidized base lesion DNA N-glycosylase activity", "DNA-(apurinic or apyrimidinic site) endonuclease activity", "base-excision repair" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "HAMAP", "PIRSF" ]

[ "MF_01168", "PIRSF008955" ]

[ "AGOG", "AGOG" ]

[ 82, 82 ]

2

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.2.2.-", "4.2.99.18", "PWY-2681", "PWY-5316", "PWY-5381", "PWY-7342", "PWY-7564", "PWY-8106" ]

[ "EC:3.2.2.-", "EC:4.2.99.18", "METACYC:PWY-2681", "METACYC:PWY-5316", "METACYC:PWY-5381", "METACYC:PWY-7342", "METACYC:PWY-7564", "METACYC:PWY-8106" ]

8

[ "1xg7", "1xqo", "1xqp", "4pii", "7olb", "7oli", "7ou3", "7oue", "7oy7", "7p0w", "7p8l", "7p9z" ]

12

[ "PUB00032495", "PUB00035524" ]

[ "15642264", "15604455" ]

[ "A DNA glycosylase from Pyrobaculum aerophilum with an 8-oxoguanine binding mode and a noncanonical helix-hairpin-helix structure.", "Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases." ]

[ 2005, 2004 ]

2

[ "IPR015254" ]

[]

1

0

1

[ "Archaea" ]

[ 84 ]

1

[]

0

true

Family

N-glycosylase/DNA lyase

AGOG

8

IPR016545

16,545

Uncharacterised conserved protein UCP009120, proteasome-type protease, Sll0069

UCP009120_prtse

Family

4,215

false

This group represents a predicted proteasome-type protease, Sll0069 type.

[]

0

[ "PIRSF" ]

[ "PIRSF009120" ]

[ "UCP009120_prtse" ]

[ 4215 ]

1

[]

0

[ "5lox", "5loy", "5nyf", "5nyg", "5nyj", "5nyp", "5nyq", "5nyr", "5nyw" ]

9

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4185, 5, 25 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP009120, proteasome-type protease, Sll0069

UCP009120_prtse

1

IPR016546

16,546

Maltodextrose utilization protein MalA

Maltodextrose_util_MalA

Family

118

false

This group represents a maltodextrose utilization protein MalA [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF009136" ]

[ "Maltodextrose_util_MalA" ]

[ 118 ]

1

[]

0

[]

0

[ "PUB00084326" ]

[ "8244973" ]

[ "Characterization of the Streptococcus pneumoniae maltosaccharide regulator MalR, a member of the LacI-GalR family of repressors displaying distinctive genetic features." ]

[ 1993 ]

1

[]

0

null

[ "Bacilli" ]

[ 118 ]

1

[]

0

true

Family

Maltodextrose utilization protein MalA

Maltodextrose_util_MalA

7

IPR016547

16,547

Antitoxin TacA

TacA

Family

30

false

This entry represents a group of proteins from Mycobacterium, including Antitoxin TacA from Mycobacterium tuberculosis. TacA is the antitoxin component of a type II toxin-antitoxin (TA) system. It counteracts the toxic effect of cognate toxin TacT [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF009158" ]

[ "UCP009158" ]

[ 30 ]

1

[]

0

[]

0

[ "PUB00158920" ]

[ "35638832" ]

[ "A tRNA-Acetylating Toxin and Detoxifying Enzyme in Mycobacterium tuberculosis." ]

[ 2022 ]

1

[ "IPR014795" ]

[]

1

0

1

[ "Mycobacterium tuberculosis complex" ]

[ 30 ]

1

[]

0

true

Family

Antitoxin TacA

TacA

2

IPR016548

16,548

Uncharacterised conserved protein UCP009180

UCP009180

Family

325

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF009180" ]

[ "UCP009180" ]

[ 325 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 85, 233, 7 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP009180

UCP009180

4

IPR016550

16,550

Guanidinoacetate N-methyltransferase

GuanidinoAc_N-MeTrfase

Family

474

false

Guanidinoacetate methyltransferase (GAMT; ) catalyses the last step of creatine biosynthesis. In humans, GAMT is believed to be the major enzyme involved in the metabolic conversion of S-adenosylmethionine (SAM) to S-adenosylhomocycteine (SAH). GAMT is found in abundance in the liver of all vertebrates. The crystal str...

[ "GO:0030731" ]

[ "guanidinoacetate N-methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF009285" ]

[ "GAMT" ]

[ 474 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1.2", "R-BTA-71288", "R-DRE-71288", "R-HSA-71288", "R-HSA-8986944", "R-MMU-71288", "R-RNO-71288", "R-XTR-71288" ]

[ "EC:2.1.1.2", "REACTOME:R-BTA-71288", "REACTOME:R-DRE-71288", "REACTOME:R-HSA-71288", "REACTOME:R-HSA-8986944", "REACTOME:R-MMU-71288", "REACTOME:R-RNO-71288", "REACTOME:R-XTR-71288" ]

8

[ "1khh", "1p1b", "1p1c", "1xcj", "1xcl", "3orh" ]

6

[ "PUB00028831", "PUB00035937", "PUB00035938" ]

[ "12079381", "9325156", "7808840" ]

[ "Crystal structure of guanidinoacetate methyltransferase from rat liver: a model structure of protein arginine methyltransferase.", "The human guanidinoacetate methyltransferase (GAMT) gene maps to a syntenic region on 19p13.3, homologous to band C of mouse chromosome 10, but GAMT is not mutated in jittery mice."...

[ 2002, 1997, 1994 ]

3

[]

0

null

[ "Bilateria" ]

[ 474 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 1, 2 ]

4

true

Family

Guanidinoacetate N-methyltransferase

GuanidinoAc_N-MeTrfase

5

IPR016551

16,551

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, metazoa

Ndufb8_metazoa

Family

755

false

Image averaging of mitochondrial complex I reveals a complex that can be dissociated into two main sub-complexes. One sub-complex is thought to protrude from the membrane so is to be predominantly in the aqueous phase and contains the binding site for NAD(H), and the input electron transfer chain. The other sub-complex...

[ "GO:0006120" ]

[ "mitochondrial electron transport, NADH to ubiquinone" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF009288" ]

[ "NDUB8" ]

[ 755 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-1268020", "R-BTA-611105", "R-BTA-6799198", "R-HSA-1268020", "R-HSA-611105", "R-HSA-6799198", "R-MMU-1268020", "R-MMU-611105", "R-MMU-6799198" ]

[ "REACTOME:R-BTA-1268020", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-HSA-1268020", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-1268020", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198" ]

9

[ "5gup", "5lnk", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6q9b", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6zka", "6zkb", "6zkc", "6zkd", "6zke", "6zkf", "6zkg", "6zkh", "6zki", "6zkj", "6zkk"...

202

[ "PUB00005074", "PUB00011390", "PUB00015242", "PUB00043561", "PUB00045437" ]

[ "1470679", "9878551", "9034360", "10940377", "18394423" ]

[ "The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.", "cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.", "Three-dimensional structure of NADH-dehydrogenase from Neurospora crassa by electron microscopy and conical tilt...

[ 1992, 1998, 1997, 2000, 2008 ]

5

[ "IPR008699" ]

[]

1

0

1

[ "Bilateria" ]

[ 755 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 1, 2 ]

5

true

Family

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, metazoa

Ndufb8_metazoa

8

IPR016553

16,553

Protein tyrosine phosphatase receptor type C-associated protein

PTPRCAP

Family

265

false

This group represents protein tyrosine phosphatase receptor type C (PTPRC)-associated protein, also known as CD45-associated protein [ , ]. It is a positive regulator of PTPRC (CD45), which activates Src family kinases implicated in tumorigenesis [ ].

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF15713", "PIRSF009325", "PTHR15312" ]

[ "PTPRCAP", "PTPRC-associated_protein", "" ]

[ 238, 103, 260 ]

3

[]

0

[]

0

[ "PUB00075837", "PUB00075838", "PUB00075839" ]

[ "8537410", "8954783", "20019842" ]

[ "Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45.", "Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes.", "A regulatory polymorphism at position -309 in PTPRCAP is associated ...

[ 1995, 1996, 2009 ]

3

[]

0

null

[ "Euteleostomi" ]

[ 265 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 3 ]

3

true

Family

Protein tyrosine phosphatase receptor type C-associated protein

PTPRCAP

2

IPR016554

16,554

Runt-related transcription factor RUNX

TF_Runt-rel_RUNX

Family

2,826

false

This group represents runt-related transcription factors RUNX. The RUNX family of transcription factors plays important roles in hematopoiesis, neurogenesis, bone development, and segmentation in vertebrate embryos. RUNX1 and its Xenopus and Drosophila homologues appear to determine hematopoietic cell fate during devel...

[]

0

[ "PIRSF" ]

[ "PIRSF009374" ]

[ "TF_Runt-rel_RUNX" ]

[ 2826 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-1912408", "R-HSA-2032785", "R-HSA-4411364", "R-HSA-549127", "R-HSA-8877330", "R-HSA-8878166", "R-HSA-8931987", "R-HSA-8934593", "R-HSA-8935964", "R-HSA-8936459", "R-HSA-8939236", "R-HSA-8939242", "R-HSA-8939243", "R-HSA-8939245", "R-HSA-8939246", "R-HSA-8939247", "R-HSA-893925...

[ "REACTOME:R-HSA-1912408", "REACTOME:R-HSA-2032785", "REACTOME:R-HSA-4411364", "REACTOME:R-HSA-549127", "REACTOME:R-HSA-8877330", "REACTOME:R-HSA-8878166", "REACTOME:R-HSA-8931987", "REACTOME:R-HSA-8934593", "REACTOME:R-HSA-8935964", "REACTOME:R-HSA-8936459", "REACTOME:R-HSA-8939236", "REACTOME...

63

[]

0

[ "PUB00064958" ]

[ "11105897" ]

[ "Potential roles for RUNX1 and its orthologs in determining hematopoietic cell fate." ]

[ 2000 ]

1

[ "IPR000040" ]

[]

1

0

1

[ "Bilateria" ]

[ 2826 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 48, 7, 12, 11 ]

4

true

Family

Runt-related transcription factor RUNX

TF_Runt-rel_RUNX

8

IPR016555

16,555

Phospholipase D, eukaryotic type

PLipase_D_euk

Family

8,395

false

This entry includes the lipid-signaling enzymes phospholipase D1 (PLD1) and D2 (PLD2) [ ]. They have roles in immune cell migration [ , ] and phagocytosis [ , ]. PLD1 is selectively required during extravasation of macrophages from the bloodstream to sites of damage [ ].

[ "GO:0004630", "GO:0006654", "GO:0035556" ]

[ "D-type glycerophospholipase activity", "phosphatidic acid biosynthetic process", "intracellular signal transduction" ]

[ "molecular_function", "biological_process", "biological_process" ]

3

[ "PIRSF" ]

[ "PIRSF009376" ]

[ "Phospholipase_D_euk" ]

[ 8395 ]

1

[ "EC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "R...

[ "3.1.4.4", "PWY-3561", "PWY-7039", "R-HSA-1483148", "R-HSA-1483166", "R-HSA-2029485", "R-HSA-6798695", "R-HSA-8980692", "R-HSA-9013148", "R-HSA-9013149", "R-HSA-9013404", "R-HSA-9013408", "R-MMU-1483166", "R-MMU-2029485", "R-MMU-6798695", "R-MMU-8980692", "R-MMU-9013149", "R-MMU-90...

[ "EC:3.1.4.4", "METACYC:PWY-3561", "METACYC:PWY-7039", "REACTOME:R-HSA-1483148", "REACTOME:R-HSA-1483166", "REACTOME:R-HSA-2029485", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013148", "REACTOME:R-HSA-9013149", "REACTOME:R-HSA-9013404", "REACTOME:R-HSA-9013408", "REA...

34

[ "6ohm", "6oho", "6ohp", "6ohq", "6ohr", "6ohs", "6u8z", "7svp" ]

8

[ "PUB00073523", "PUB00073524", "PUB00073525", "PUB00073526", "PUB00073527", "PUB00073528" ]

[ "9395408", "20647543", "15294978", "16497229", "19325080", "23383154" ]

[ "Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization.", "The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts.", "Phospholipases D1 and D2 coordinately regulate ...

[ 1997, 2010, 2004, 2006, 2009, 2013 ]

6

[ "IPR015679" ]

[]

1

0

1

[ "Eukaryota" ]

[ 8395 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 14, 1, 16, 6, 5, 9, 2, 4, 12, 1, 1, 13 ]

12

true

Family

Phospholipase D, eukaryotic type

PLipase_D_euk

5

IPR016557

16,557

Cyclic 2,3-diphosphoglycerate synthetase

CpgS

Family

117

false

CpgS is a low molecular weight compound that accumulates to high levels in some hyperthermophilic methanogens, suggesting that it may play a thermoadaptive role. The full-length enzyme catalyses the formation of cyclic 2,3-diphosphoglycerate from 2,3- bisphosphoglycerate and ATP . It has also been shown to protect prot...

[ "GO:0036356", "GO:0006094", "GO:0005737" ]

[ "cyclic 2,3-diphosphoglycerate synthetase activity", "gluconeogenesis", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PIRSF" ]

[ "MF_01908", "PIRSF009445" ]

[ "Cyc_PG_syn", "Cyc_PG_syn" ]

[ 116, 113 ]

2

[ "EC", "METACYC" ]

[ "6.5.1.9", "PWY-8098" ]

[ "EC:6.5.1.9", "METACYC:PWY-8098" ]

2

[ "8ork", "8oru" ]

2

[ "PUB00046149", "PUB00053142" ]

[ "9811660", "2226838" ]

[ "Cloning, sequencing, and expression of the gene encoding cyclic 2, 3-diphosphoglycerate synthetase, the key enzyme of cyclic 2, 3-diphosphoglycerate metabolism in Methanothermus fervidus.", "Biosynthesis of cyclic 2,3-diphosphoglycerate. Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-...

[ 1998, 1990 ]

2

[]

0

null

[ "Bacteria", "Methanobacteriota", "ecological metagenomes" ]

[ 17, 98, 2 ]

3

[]

0

true

Family

Cyclic 2,3-diphosphoglycerate synthetase

CpgS

2

IPR016558

16,558

DNA primase, large subunit, eukaryotic

DNA_primase_lsu_euk

Family

4,252

false

DNA primase is the polymerase that synthesises small RNA primers for the Okazaki fragments made during discontinuous DNA replication. Primases are grouped into two classes, bacteria/bacteriophage and archaeal/eukaryotic. The proteins in the two classes differ in structure and the replication apparatus components. Archa...

[]

0

[ "PIRSF", "CDD" ]

[ "PIRSF009449", "cd07322" ]

[ "DNA_primase_large_subunit", "PriL_PriS_Eukaryotic" ]

[ 3434, 4252 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-113501", "R-CEL-68952", "R-CEL-68962", "R-CEL-69091", "R-CEL-69166", "R-CEL-69183", "R-DDI-113501", "R-DDI-68952", "R-DDI-68962", "R-DDI-69091", "R-DDI-69166", "R-DDI-69183", "R-DME-113501", "R-DME-68952", "R-DME-68962", "R-DME-69091", "R-DME-69166", "R-DME-69183", "R-HSA-...

[ "REACTOME:R-CEL-113501", "REACTOME:R-CEL-68952", "REACTOME:R-CEL-68962", "REACTOME:R-CEL-69091", "REACTOME:R-CEL-69166", "REACTOME:R-CEL-69183", "REACTOME:R-DDI-113501", "REACTOME:R-DDI-68952", "REACTOME:R-DDI-68962", "REACTOME:R-DDI-69091", "REACTOME:R-DDI-69166", "REACTOME:R-DDI-69183", "R...

55

[ "3l9q", "3q36", "4rr2", "5dqo", "5exr", "5f0q", "5f0s", "5i7m", "6dhw", "7opl", "7u5c", "7uy8", "8b9a", "8b9b", "8b9c", "8b9d", "8d0k", "8d96", "8d9d", "8foc", "8fod", "8foe", "8foh", "8foj", "8fok", "8g99", "8g9f", "8g9l", "8g9o", "8qj7", "8ucv", "8v5m"...

40

[ "PUB00005693", "PUB00009835", "PUB00009837", "PUB00039010" ]

[ "2023935", "2528682", "8026492", "16273105" ]

[ "Mutations in conserved yeast DNA primase domains impair DNA replication in vivo.", "A single essential gene, PRI2, encodes the large subunit of DNA primase in Saccharomyces cerevisiae.", "DNA replication in vitro by recombinant DNA-polymerase-alpha-primase.", "Structure of the heterodimeric core primase." ]

[ 1991, 1989, 1994, 2005 ]

4

[ "IPR007238" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4252 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 2, 3, 2, 3, 3, 1, 3, 4, 1, 1, 10 ]

12

true

Family

DNA primase, large subunit, eukaryotic

DNA_primase_lsu_euk

8