LiteFold/InterPro · Datasets at Hugging Face

IPR016560

16,560

T-cell leukemia translocation-altered gene protein

TCTA

Family

608

false

This entry represents the T-cell leukemia translocation-altered gene protein. It may be required for cellular fusion during osteoclastogenesis [ ].

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF15128", "PIRSF009935", "PTHR32267" ]

[ "T_cell_tran_alt", "TCTA", "" ]

[ 602, 419, 600 ]

3

[]

0

[]

0

[ "PUB00067607" ]

[ "19560569" ]

[ "T-cell leukemia translocation-associated gene (TCTA) protein is required for human osteoclastogenesis." ]

[ 2009 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 608 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3, 5 ]

4

true

Family

T-cell leukemia translocation-altered gene protein

TCTA

2

IPR016561

16,561

Dynein light chain roadblock-type 1/2

DYNLRB1/2

Family

2,573

false

Dynein light chain roadblock proteins (DYNLRB1 and DYNLRB2) are non-catalytic accessory components of the cytoplasmic dynein 1 complex. The dynein light chains are required for the correct assembly of the dynein complex and have been implicated in controlling its association with cargo molecules. DYNLRB1 and DYNLRB2 ca...

[ "GO:0007018", "GO:0005868" ]

[ "microtubule-based movement", "cytoplasmic dynein complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF009998" ]

[ "DLC7" ]

[ 2573 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5620924", "R-HSA-5620924", "R-MMU-5620924", "R-RNO-5620924" ]

[ "REACTOME:R-BTA-5620924", "REACTOME:R-HSA-5620924", "REACTOME:R-MMU-5620924", "REACTOME:R-RNO-5620924" ]

4

[ "1y4o", "1z09", "2b95", "2e8j", "2hz5", "3l7h", "3l9k", "6f1t", "6f1z", "6f38", "6f3a", "6rlb", "6sc2", "6zyw", "7k58", "7kzm", "7kzn", "7z8f", "8glv", "8j07", "8pr1", "8ptk", "8rgg", "8rgh", "9bly", "9dgr", "9e12", "9e13", "9e14", "9e23", "9e28", "9e5c"...

33

[ "PUB00075597" ]

[ "25205765" ]

[ "Subunit composition of the human cytoplasmic dynein-2 complex." ]

[ 2014 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2573 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 6, 5, 4, 3, 5 ]

6

true

Family

Dynein light chain roadblock-type 1/2

DYNLRB1/2

1

IPR016562

16,562

Proteasome assembly chaperone 2, eukaryotic

Proteasome_assmbl_chp_2_euk

Family

2,978

false

This PAC2 (Proteasome assembly chaperone) family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 247 and 307 amino acids in length. Its C-terminal segment containing the potential proteasome-activating HbYX motif. These proteins function as a chaperone for the 26S...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF010044", "PTHR12970" ]

[ "UCP010044", "" ]

[ 2174, 2978 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9907900", "R-DDI-9907900", "R-DRE-9907900", "R-HSA-9907900", "R-MMU-9907900", "R-SCE-9907900", "R-XTR-9907900" ]

[ "REACTOME:R-BTA-9907900", "REACTOME:R-DDI-9907900", "REACTOME:R-DRE-9907900", "REACTOME:R-HSA-9907900", "REACTOME:R-MMU-9907900", "REACTOME:R-SCE-9907900", "REACTOME:R-XTR-9907900" ]

7

[ "4g4s", "7ls6", "7lsx", "8qyj", "8qyl", "8qym", "8qyn", "8qys", "8qz9", "8rvl", "8rvo", "8rvp", "8t08", "8tm3", "8tm4", "8tm5", "8tm6", "8u6y", "8yix", "8yiy", "8yiz" ]

21

[ "PUB00043418", "PUB00044890", "PUB00053374", "PUB00053375" ]

[ "16251969", "17707236", "18786393", "17431397" ]

[ "A heterodimeric complex that promotes the assembly of mammalian 20S proteasomes.", "20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals.", "PACemakers of proteasome core particle assembly.", "beta-Subunit appendages promote 20S proteasome assembly by overcoming...

[ 2005, 2007, 2008, 2007 ]

4

[ "IPR019151" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2978 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 7, 2, 1, 12, 1, 3, 2, 1, 7 ]

9

true

Family

Proteasome assembly chaperone 2, eukaryotic

Proteasome_assmbl_chp_2_euk

3

IPR016563

16,563

Nuclear protein localization protein 4

Npl4

Family

5,739

false

Npl4 forms the Cdc48-Ufd1-Npl4 complex, which is a segregase complex that is involved in several ubiquitin-related processes. By coupling the ubiquitin-binding properties of Ufd1-Npl4 with the ATPase activity of Cdc48 (p97 in mammals), Cdc48-Ufd1-Npl4 is believed to aid in the extraction of ubiquitylated proteins from ...

[ "GO:0006511" ]

[ "ubiquitin-dependent protein catabolic process" ]

[ "biological_process" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF010052", "PTHR12710" ]

[ "Polyub_prc_Npl4", "" ]

[ 3625, 5739 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-110320", "R-CEL-8951664", "R-CEL-9755511", "R-DDI-8951664", "R-DDI-9755511", "R-DME-110320", "R-DME-8951664", "R-DME-9755511", "R-HSA-110320", "R-HSA-8951664", "R-HSA-9755511", "R-MMU-110320", "R-MMU-8951664", "R-MMU-9755511", "R-RNO-110320", "R-RNO-8951664", "R-RNO-9755511", ...

[ "REACTOME:R-CEL-110320", "REACTOME:R-CEL-8951664", "REACTOME:R-CEL-9755511", "REACTOME:R-DDI-8951664", "REACTOME:R-DDI-9755511", "REACTOME:R-DME-110320", "REACTOME:R-DME-8951664", "REACTOME:R-DME-9755511", "REACTOME:R-HSA-110320", "REACTOME:R-HSA-8951664", "REACTOME:R-HSA-9755511", "REACTOME:R...

23

[ "1wf9", "2pjh", "6cdd", "6chs", "6jwh", "6jwi", "6jwj", "6oa9", "6oaa", "7wwp", "7wwq", "8dar", "8das", "8dat", "8dau", "8dav", "8daw", "9m3z", "9ofv" ]

19

[ "PUB00077106", "PUB00077110" ]

[ "26537787", "21070972" ]

[ "Targeting of SUMO substrates to a Cdc48-Ufd1-Npl4 segregase and STUbL pathway in fission yeast.", "A stress-responsive system for mitochondrial protein degradation." ]

[ 2015, 2010 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5739 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 2, 1, 1, 9, 4, 2, 2, 7, 1, 1, 12 ]

12

true

Family

Nuclear protein localization protein 4

Npl4

3

IPR016564

16,564

Uncharacterized membrane protein YGR016W, fungi

YGR016W_fungi

Family

28

false

YGR016W contains an all helical fold. It is present with 238 molecules/cell in log phase SD medium [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF010056" ]

[ "UCP010056" ]

[ 28 ]

1

[]

0

[]

0

[ "PUB00042821" ]

[ "14562106" ]

[ "Global analysis of protein expression in yeast." ]

[ 2003 ]

1

[ "IPR060744" ]

[]

1

0

1

[ "Saccharomycotina" ]

[ 28 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Uncharacterized membrane protein YGR016W, fungi

YGR016W_fungi

5

IPR016565

16,565

Proteasome assembly chaperone 1

Proteasome_assmbl_chp_1

Family

1,589

false

This entry represents proteasome assembly chaperone 1 (PAC1). The 26S proteasome plays a critical role in a number of cellular processes including cell-cycle control, transcription, signal transduction and DNA repair [ ]. This complex is composed of a catalytic 20S proteasome and two axially positioned 19S regulatory c...

[ "GO:0043248", "GO:0005783" ]

[ "proteasome assembly", "endoplasmic reticulum" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF16094", "PIRSF010076", "PTHR15069" ]

[ "PAC1", "Psome_chaperone-1", "" ]

[ 1393, 214, 1502 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-9907900", "R-DDI-9907900", "R-DRE-9907900", "R-HSA-9907900", "R-MMU-9907900", "R-XTR-9907900" ]

[ "REACTOME:R-BTA-9907900", "REACTOME:R-DDI-9907900", "REACTOME:R-DRE-9907900", "REACTOME:R-HSA-9907900", "REACTOME:R-MMU-9907900", "REACTOME:R-XTR-9907900" ]

6

[ "8qyj", "8qyl", "8qym", "8qyn", "8qys", "8qz9", "8tm3", "8tm4", "8tm5", "8tm6", "8yix", "8yiy", "8yiz" ]

13

[ "PUB00016866", "PUB00076216", "PUB00076217" ]

[ "15571806", "20074030", "19165213" ]

[ "The proteasome: a proteolytic nanomachine of cell regulation and waste disposal.", "Chaperone-assisted assembly of the proteasome core particle.", "Molecular mechanisms of proteasome assembly." ]

[ 2004, 2010, 2009 ]

3

[]

0

null

[ "Eukaryota" ]

[ 1589 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 3, 3, 8 ]

5

true

Family

Proteasome assembly chaperone 1

Proteasome_assmbl_chp_1

7

IPR016566

16,566

Uncharacterised conserved protein UCP010219

UCP010219

Family

5,830

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. However, they are predicted to be integral membrane proteins (with several transmembrane segments). Homologues are predominantly from Actinobacteria.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF11361", "PIRSF010219" ]

[ "DUF3159", "UCP010219" ]

[ 5830, 3091 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 5670, 160 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP010219

UCP010219

8

IPR016567

16,567

Cysteine-rich protein, furovirus

Cys-rich_furovirus

Family

27

false

This group represents a cysteine-rich protein of unknown function found in the ssRNA positive strand Furovirus group.

[]

0

[ "PIRSF" ]

[ "PIRSF010309" ]

[ "Cyc-rich_ssRNA" ]

[ 27 ]

1

[]

0

[]

0

[]

0

[ "IPR007609" ]

[]

1

0

1

[ "Virgaviridae" ]

[ 27 ]

1

[]

0

true

Family

Cysteine-rich protein, furovirus

Cys-rich_furovirus

3

IPR016568

16,568

Sulphur oxidation, SoxY

Sulphur_oxidation_SoxY

Family

2,306

false

SoxY is encoded by one of the genes in the sulphur oxidizing gene cluster of alpha-proteobacteria. In the sulphur oxidation process, SoxY (which covalently binds sulphur) and SoxZ (which chelates sulphur) combine with each other to form the SoxYZ complex. The conserved cysteine residue in the sulphate-binding motif [(V...

[]

0

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF010312", "TIGR04488" ]

[ "Sulphur_oxidation_SoxY", "SoxY_true_GGCGG" ]

[ 2282, 1719 ]

2

[ "GP" ]

[ "GenProp1088" ]

[ "GP:GenProp1088" ]

1

[ "2nnc", "2nnf", "2ox5", "2oxg", "2oxh", "4uwq" ]

6

[ "PUB00035939", "PUB00035940", "PUB00048562" ]

[ "14651972", "16084835", "17522046" ]

[ "Sulfur oxidation in Paracoccus pantotrophus: interaction of the sulfur-binding protein SoxYZ with the dimanganese SoxB protein.", "A structural study towards the understanding of the interactions of SoxY, SoxZ, and SoxB, leading to the oxidation of sulfur anions via the novel global sulfur oxidizing (sox) operon...

[ 2003, 2005, 2007 ]

3

[]

[ "IPR030997" ]

0

1

0

[ "Bacteria", "Protostomia", "unclassified sequences" ]

[ 2233, 2, 71 ]

3

[]

0

true

Family

Sulphur oxidation, SoxY

Sulphur_oxidation_SoxY

3

IPR016569

16,569

Methyltransferase, trithorax

MeTrfase_trithorax

Family

1,437

false

This entry includes a group of histone methyltransferases. The enzyme activity has been mapped to the SET domain [ ], originally identified in Drosophila melanogaster (Fruit fly) Su(var)3-9, E(z) and Trithorax proteins [ ]. The mixed lineage leukemia (MLL) gene encodes a very large nuclear protein homologous to Drosoph...

[ "GO:0008270", "GO:0042800", "GO:0006355", "GO:0035097" ]

[ "zinc ion binding", "histone H3K4 methyltransferase activity", "regulation of DNA-templated transcription", "histone methyltransferase complex" ]

[ "molecular_function", "molecular_function", "biological_process", "cellular_component" ]

4

[ "PIRSF" ]

[ "PIRSF010354" ]

[ "Methyltransferase_trithorax" ]

[ 1437 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1.364", "R-DME-8936459", "R-DME-8939236", "R-DME-9772755", "R-HSA-3214841", "R-HSA-8936459", "R-HSA-8939236", "R-HSA-9616222", "R-HSA-9772755", "R-HSA-9931510", "R-HSA-9931512", "R-HSA-9931521", "R-MMU-3214841", "R-MMU-8936459", "R-MMU-8939236", "R-MMU-9772755" ]

[ "EC:2.1.1.364", "REACTOME:R-DME-8936459", "REACTOME:R-DME-8939236", "REACTOME:R-DME-9772755", "REACTOME:R-HSA-3214841", "REACTOME:R-HSA-8936459", "REACTOME:R-HSA-8939236", "REACTOME:R-HSA-9616222", "REACTOME:R-HSA-9772755", "REACTOME:R-HSA-9931510", "REACTOME:R-HSA-9931512", "REACTOME:R-HSA-99...

16

[]

0

[ "PUB00007132", "PUB00014615", "PUB00014616", "PUB00073505" ]

[ "12039029", "12699618", "12447353", "15779005" ]

[ "SET-domain proteins of the Su(var)3-9, E(z) and trithorax families.", "ATX-1, an Arabidopsis homolog of trithorax, activates flower homeotic genes.", "SET domain proteins reSET gene expression.", "MLL: how complex does it get?" ]

[ 2002, 2003, 2002, 2005 ]

4

[]

0

null

[ "Bilateria" ]

[ 1437 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 1, 7, 5, 6 ]

5

true

Family

Methyltransferase, trithorax

MeTrfase_trithorax

1

IPR016570

16,570

Uncharacterised conserved protein UCP010361, membrane

UCP010361

Family

4,357

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. However, they are predicted to be integral membrane proteins (with several transmembrane segments).

[]

0

[ "PIRSF" ]

[ "PIRSF010361" ]

[ "UCP010361" ]

[ 4357 ]

1

[]

0

[]

0

[]

0

[ "IPR018584" ]

[]

1

0

1

[ "Actinomycetes", "Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)", "metagenomes" ]

[ 4329, 1, 27 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP010361, membrane

UCP010361

8

IPR016571

16,571

Spore coat assembly protein CotJB

Spore_coat_assembly_CotJB

Family

1,799

false

This group represents a spore coat peptide assembly protein CotJB.

[]

0

[ "PIRSF" ]

[ "PIRSF010606" ]

[ "Spore_coat_CotJB" ]

[ 1799 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillati", "ecological metagenomes" ]

[ 1792, 7 ]

2

[]

0

true

Family

Spore coat assembly protein CotJB

Spore_coat_assembly_CotJB

1

IPR016572

16,572

Uncharacterised conserved protein UCP010611

UCP010611

Family

419

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF010611" ]

[ "UCP010611" ]

[ 419 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycobacteriales" ]

[ 419 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP010611

UCP010611

7

IPR016574

16,574

Nicalin

Family

3,453

false

Nicalin is a Nodal signalling antagonist and a distant homologue of the gamma-secretase component Nicastrin [ ]. In humans, Nicalin forms a complex with NOMO (Nodal modulator) and controls the assembly and stability of this complex [ ]. It is a component of the multi-pass translocon (MPT) complex that mediates insertio...

[ "GO:0009966", "GO:0016020" ]

[ "regulation of signal transduction", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF011018", "PTHR31826" ]

[ "Nicalin", "" ]

[ 1757, 3453 ]

2

[]

0

[ "6w6l", "7tm3", "7tut", "9c7u", "9c7v" ]

5

[ "PUB00054165", "PUB00062803", "PUB00097241", "PUB00103609" ]

[ "15257293", "17261586", "32820719", "36261522" ]

[ "Nicalin and its binding partner Nomo are novel Nodal signaling antagonists.", "The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex.", "An ER translocon for multi-pass membrane protein biogenesis.", "Substrate-driven assembly of a ...

[ 2004, 2007, 2020, 2022 ]

4

[]

0

null

[ "Eukaryota", "bacterium (Candidatus Ratteibacteria) CG_4_10_14_3_um_filter_41_18" ]

[ 3452, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 4, 2, 8, 3, 2, 6, 23 ]

9

true

Family

Nicalin

8

IPR016575

16,575

Bardet-Biedl syndrome 7 protein

Bardet-Biedl_syndrome_7_prot

Family

850

false

This group represents a Bardet-Biedl syndrome 7 protein from Caenorhabditis elegans and similar animal proteins. This component of the BBSome complex plays a role in guanylyl cyclase localisation in the ring-like structures at the base of the finger compartment in AFD sensory neurons [ ]. In ciliated sensory neurons, i...

[ "GO:1905515", "GO:0034464" ]

[ "non-motile cilium assembly", "BBSome" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF011091" ]

[ "BBS7" ]

[ 850 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-5620922", "R-HSA-5620922", "R-MMU-5620922" ]

[ "REACTOME:R-CEL-5620922", "REACTOME:R-HSA-5620922", "REACTOME:R-MMU-5620922" ]

3

[ "6vbu", "6vbv", "6vnw", "6voa" ]

4

[ "PUB00043590", "PUB00043591", "PUB00043592", "PUB00043593", "PUB00154979", "PUB00154980" ]

[ "18506366", "18317593", "18334641", "18032602", "25335890", "30014846" ]

[ "Regulation of Alstrom syndrome gene expression during adipogenesis and its relationship with fat cell insulin sensitivity.", "Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome.", "Bardet-Biedl syndrome proteins are required for the localization of G protein-coup...

[ 2008, 2008, 2008, 2007, 2014, 2018 ]

6

[]

0

null

[ "Eumetazoa" ]

[ 850 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 1, 6, 6 ]

5

true

Family

Bardet-Biedl syndrome 7 protein

Bardet-Biedl_syndrome_7_prot

7

IPR016576

16,576

Large ribosomal subunit protein mL63

Ribosomal_mL63

Family

1,260

false

This entry represents the large ribosomal subunit protein mL63 from animals, which was previously known as Mitochondrial ribosomal protein 63 or Mrpl57. This protein is present in the intact 55S subunit of the mitochondrial ribosome. It is not known if it belongs to the 28S or to the 39S subunit [ ].

[ "GO:0005761" ]

[ "mitochondrial ribosome" ]

[ "cellular_component" ]

1

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF14978", "PIRSF011124", "PTHR14520" ]

[ "MRP-63", "MRP63", "" ]

[ 1260, 178, 1156 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5389840", "R-BTA-5419276", "R-BTA-9937383", "R-DRE-5389840", "R-DRE-5419276", "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383" ]

[ "REACTOME:R-BTA-5389840", "REACTOME:R-BTA-5419276", "REACTOME:R-BTA-9937383", "REACTOME:R-DRE-5389840", "REACTOME:R-DRE-5419276", "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOM...

12

[ "3j7y", "3j9m", "4v1a", "5aj4", "5ool", "5oom", "6gaw", "6gb2", "6i9r", "6nu2", "6nu3", "6vlz", "6vmi", "6ydp", "6ydw", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse", "6zsg", "7a5f", "7a5g", "7a5h", "7a5i", "7a5j", "7a5k", "7l08", "7l20"...

90

[ "PUB00044378" ]

[ "11402041" ]

[ "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit." ]

[ 2001 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 1260 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 1, 2 ]

5

true

Family

Large ribosomal subunit protein mL63

Ribosomal_mL63

1

IPR016577

16,577

Adenylate cyclase, type 10

Adenylate_cyclase_typ10

Family

19

false

This entry represents type 10 adenylate cyclases (also known as soluble adenylyl cyclase; ), which produces cAMP and phosphate from ATP. This enzyme has a critical role in mammalian spermatogenesis by producing cAMP to mediate the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis [...

[ "GO:0000287", "GO:0004016", "GO:0006171", "GO:0007283" ]

[ "magnesium ion binding", "adenylate cyclase activity", "cAMP biosynthetic process", "spermatogenesis" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "PIRSF" ]

[ "PIRSF011131" ]

[ "Soluble_adenylyl_cyclase" ]

[ 19 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME" ]

[ "4.6.1.1", "R-HSA-5610787", "R-MMU-5610787", "R-RNO-5610787" ]

[ "EC:4.6.1.1", "REACTOME:R-HSA-5610787", "REACTOME:R-MMU-5610787", "REACTOME:R-RNO-5610787" ]

4

[]

0

[ "PUB00042963" ]

[ "18255013" ]

[ "Soluble adenylyl cyclase is required for activation of sperm but does not have a direct effect on hyperactivation." ]

[ 2008 ]

1

[]

0

null

[ "Euarchontoglires" ]

[ 19 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 1 ]

3

true

Family

Adenylate cyclase, type 10

Adenylate_cyclase_typ10

5

IPR016578

16,578

SODIUM POTASSIUM ROOT DEFECTIVE 2/3

NAKR2/3

Family

99

false

This family represents a group of heavy metal-associated plant proteins (HPPs) [ ], which includes Arabidopsis SODIUM POTASSIUM ROOT DEFECTIVE 2 (NAKR2) and 3 (NAKR3). NAKR3 is involved in the salt stress response in Arabidopsis [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF011221" ]

[ "Chloropl_CC_prd" ]

[ 99 ]

1

[]

0

[]

0

[ "PUB00082320", "PUB00082594" ]

[ "23368984", "26909945" ]

[ "Heavy metal-associated isoprenylated plant protein (HIPP): characterization of a family of proteins exclusive to plants.", "Overexpression of NaKR3 enhances salt tolerance in Arabidopsis." ]

[ 2013, 2016 ]

2

[ "IPR044526" ]

[]

1

0

1

[ "Brassicaceae" ]

[ 99 ]

1

[ "Arabidopsis thaliana" ]

[ 11 ]

1

true

Family

SODIUM POTASSIUM ROOT DEFECTIVE 2/3

NAKR2/3

6

IPR016579

16,579

Synaptogyrin

Family

4,471

false

This entry represents synaptogyrin1-4. They are conserved components of the exocytic apparatus and function as regulators of Ca(2+)-dependent exocytosis [ ]. Synaptogyrin-1 is involved in the regulation of short-term and long-term synaptic plasticity [ ].

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF011282", "PTHR10838" ]

[ "Synaptogyrin", "" ]

[ 2812, 4471 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-6798695", "R-DME-6798695", "R-HSA-6798695", "R-MMU-6798695", "R-RNO-6798695" ]

[ "REACTOME:R-CEL-6798695", "REACTOME:R-DME-6798695", "REACTOME:R-HSA-6798695", "REACTOME:R-MMU-6798695", "REACTOME:R-RNO-6798695" ]

5

[ "8a6m" ]

1

[ "PUB00069066", "PUB00073583" ]

[ "10595519", "23636420" ]

[ "Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I.", "Expression of synaptogyrin-1 in T1R2-expressing type II taste cells and type III taste cells of rat circumvallate taste buds." ]

[ 1999, 2013 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4471 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 7, 1, 17, 12, 18 ]

6

true

Family

Synaptogyrin

3

IPR016580

16,580

HUS1

Family

3,874

false

HUS1 is a component of the 9-1-1 cell-cycle checkpoint response complex (which consists of Rad9, Hus1, Rad1), a key complex in the coordination of DNA damage sensing, cell cycle progression and DNA repair pathways. In humans, the 9-1-1 complex is recruited to DNA lesions upon damage by the RAD17-replication factor C (R...

[ "GO:0000077", "GO:0005730", "GO:0030896" ]

[ "DNA damage checkpoint signaling", "nucleolus", "checkpoint clamp complex" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF011312" ]

[ "Cell_cycle_HUS1" ]

[ 3874 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-176187", "R-DME-176187", "R-DME-5693607", "R-DME-6804756", "R-DME-69473", "R-HSA-176187", "R-HSA-5685938", "R-HSA-5693607", "R-HSA-5693616", "R-HSA-6804756", "R-HSA-69473", "R-HSA-9709570", "R-MMU-176187", "R-MMU-5685938", "R-MMU-5693607", "R-MMU-6804756", "R-MMU-69473", "R-...

[ "REACTOME:R-DDI-176187", "REACTOME:R-DME-176187", "REACTOME:R-DME-5693607", "REACTOME:R-DME-6804756", "REACTOME:R-DME-69473", "REACTOME:R-HSA-176187", "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5693607", "REACTOME:R-HSA-5693616", "REACTOME:R-HSA-6804756", "REACTOME:R-HSA-69473", "REACTOME:R-HSA...

18

[ "3a1j", "3g65", "3ggr", "6j8y", "7z6h", "8gnn", "8wu8" ]

7

[ "PUB00062241" ]

[ "21659603" ]

[ "A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling." ]

[ 2011 ]

1

[ "IPR007150" ]

[]

1

0

1

[ "Eukaryota" ]

[ 3874 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 4, 1, 1, 2, 7, 3, 1, 3, 4, 1, 10 ]

11

true

Family

HUS1

2

IPR016581

16,581

CRISPR-associated protein Cas7, subtype I-B/Tneap, bacterial

Cas7/Cst2/DevR_bac

Family

100

false

CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading n...

[ "GO:0051607" ]

[ "defense response to virus" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF011362" ]

[ "Fruiting_body_devlp_DevR" ]

[ 100 ]

1

[]

0

[]

0

[ "PUB00013509", "PUB00042866" ]

[ "7693658", "17015832" ]

[ "devRS, an autoregulated and essential genetic locus for fruiting body development in Myxococcus xanthus.", "Evolution of sensory complexity recorded in a myxobacterial genome." ]

[ 1993, 2006 ]

2

[ "IPR013414" ]

[]

1

0

1

[ "Bacteria" ]

[ 100 ]

1

[]

0

true

Family

CRISPR-associated protein Cas7, subtype I-B/Tneap, bacterial

Cas7/Cst2/DevR_bac

1

IPR016582

16,582

D-(-)-3-hydroxybutyrate oligomer hydrolase, putative

OHBut_olig_hydro_put

Family

1,412

false

This entry represents a group of predicted D-(-)-3-hydroxybutyrate oligomer hydrolases (also known as 3HB-oligomer hydrolase), which function in the degradation of poly-3-hydroxybutyrate (PHB). These enzymes catalyse the hydrolysis of D(-)-3-hydroxybutyrate oligomers (3HB-oligomers) into 3HB-monomers [ , ].

[ "GO:0047989", "GO:0019605", "GO:0005615" ]

[ "hydroxybutyrate-dimer hydrolase activity", "butyrate metabolic process", "extracellular space" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "HAMAP", "PFAM", "PIRSF" ]

[ "MF_01906", "PF10605", "PIRSF011409" ]

[ "3HBOH", "3HBOH", "HObutyrate_olig_hydrol" ]

[ 352, 1412, 595 ]

3

[ "EC" ]

[ "3.1.1.22" ]

[ "EC:3.1.1.22" ]

1

[]

0

[ "PUB00044871", "PUB00044872" ]

[ "16233278", "15170237" ]

[ "Cloning of an intracellular D(-)-3-hydroxybutyrate-oligomer hydrolase gene from Ralstonia eutropha H16 and identification of the active site serine residue by site-directed mutagenesis.", "Roles of poly(3-hydroxybutyrate) depolymerase and 3HB-oligomer hydrolase in bacterial PHB metabolism." ]

[ 2002, 2004 ]

2

[]

0

null

[ "Bacteria", "Knufia peltigerae", "unclassified sequences" ]

[ 1402, 1, 9 ]

3

[]

0

true

Family

D-(-)-3-hydroxybutyrate oligomer hydrolase, putative

OHBut_olig_hydro_put

5

IPR016583

16,583

Uncharacterised conserved protein UCP011452, HNH endonuclease domain-type

UCP011452_HNH_endonucl

Family

67

false

There is currently no experimental data for members of this group or their homologues. However, they contain a version of the HNH endonuclease domain ( ).

[]

0

[ "PIRSF" ]

[ "PIRSF011452" ]

[ "UCP011452_HNH" ]

[ 67 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Enterobacterales" ]

[ 67 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP011452, HNH endonuclease domain-type

UCP011452_HNH_endonucl

9

IPR016585

16,585

Glycine/sarcosine/betaine reductase, component B, fused alpha/beta

Gly/sarc/bet_Rdtase_B_asu/bsu

Family

765

false

This group represents a glycine/sarcosine/betaine reductase, component B, fused alpha/beta subunits.

[ "GO:0050485" ]

[ "oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF011588" ]

[ "Gly_sarc_betain_red_a/b" ]

[ 765 ]

1

[]

0

[]

0

[]

0

[ "IPR015417" ]

[]

1

0

1

[ "Bacteria", "metagenomes" ]

[ 759, 6 ]

2

[]

0

true

Family

Glycine/sarcosine/betaine reductase, component B, fused alpha/beta

Gly/sarc/bet_Rdtase_B_asu/bsu

3

IPR016586

16,586

Mitochondrial transcription factor Mtf1

Mtf1

Family

32

false

The yeast mitochondrial RNA polymerase (RNAP) is a two-subunit enzyme composed of a catalytic core (Rpo41) and a specificity factor (Mtf1) encoded by nuclear genes [ ]. Though related to RNA methyltransferases, Mtf1 might be a functional analogue of the bacterial initiation factor sigma [ ]. This group represents Mtf1 ...

[ "GO:0034246", "GO:0006391", "GO:0005739" ]

[ "mitochondrial transcription factor activity", "transcription initiation at mitochondrial promoter", "mitochondrion" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF011649" ]

[ "MtTFB" ]

[ 32 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.1.1.-", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-601", "PWY-6045"...

[ "EC:2.1.1.-", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-5729", "METACYC:PWY-5...

147

[ "1i4w", "6ymv", "6ymw", "8ap1", "8att", "8atv", "8atw", "8c5s", "8c5u", "8q63" ]

10

[ "PUB00072562", "PUB00072563" ]

[ "12021282", "19920143" ]

[ "Mutations in the yeast mitochondrial RNA polymerase specificity factor, Mtf1, verify an essential role in promoter utilization.", "Multiple functions of yeast mitochondrial transcription factor Mtf1p during initiation." ]

[ 2002, 2010 ]

2

[ "IPR001737" ]

[]

1

0

1

[ "Saccharomycotina" ]

[ 32 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Mitochondrial transcription factor Mtf1

Mtf1

9

IPR016587

16,587

DNA damage checkpoint control protein Rad17

Rad17

Family

63

false

This entry represents Rad17 from budding yeast (the homologue of human and S. pombe Rad1). Rad17 is a component of the checkpoint clamp complex (Ddc1/Mec3/Rad17) involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of ...

[ "GO:0003684", "GO:0003690", "GO:0000077", "GO:0006302", "GO:0007131", "GO:0030896" ]

[ "damaged DNA binding", "double-stranded DNA binding", "DNA damage checkpoint signaling", "double-strand break repair", "reciprocal meiotic recombination", "checkpoint clamp complex" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process", "biological_process", "cellular_component" ]

6

[ "PIRSF" ]

[ "PIRSF011769" ]

[ "Cell_cycle_RAD17" ]

[ 63 ]

1

[ "REACTOME" ]

[ "R-SCE-176187" ]

[ "REACTOME:R-SCE-176187" ]

1

[ "7sgz", "7sh2", "7st9", "7stb", "8dqw", "8fs3", "8fs4", "8fs5", "8fs6", "8fs7", "8fs8" ]

11

[ "PUB00059228", "PUB00059229", "PUB00060227", "PUB00060229", "PUB00062237", "PUB00062287" ]

[ "8649984", "12604797", "9891048", "9670034", "7491494", "16169844" ]

[ "Cloning and characterization of RAD17, a gene controlling cell cycle responses to DNA damage in Saccharomyces cerevisiae.", "Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.", "Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway.", "Mec1p is esse...

[ 1996, 2003, 1999, 1998, 1995, 2005 ]

6

[ "IPR003021" ]

[]

1

0

1

[ "Saccharomycotina" ]

[ 63 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

DNA damage checkpoint control protein Rad17

Rad17

1

IPR016588

16,588

Replication factor A protein 3, Saccharomycetes

Rfp3_Saccharomycetes

Family

26

false

This entry represents Rfa3 from budding yeasts. Rfa3 is a component of the replication protein A (RPA) complex, which binds to and removes secondary structure from ssDNA. The RPA complex is involved in DNA replication, repair, and recombination [ ].

[ "GO:0003677", "GO:0006260", "GO:0006281", "GO:0006310", "GO:0005634" ]

[ "DNA binding", "DNA replication", "DNA repair", "DNA recombination", "nucleus" ]

[ "molecular_function", "biological_process", "biological_process", "biological_process", "cellular_component" ]

5

[ "PIRSF" ]

[ "PIRSF011773" ]

[ "Rep_factor-A_4" ]

[ 26 ]

1

[]

0

[ "6i52" ]

1

[ "PUB00066967" ]

[ "22842922" ]

[ "Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress." ]

[ 2012 ]

1

[ "IPR013970" ]

[]

1

0

1

[ "Saccharomycetaceae" ]

[ 26 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Replication factor A protein 3, Saccharomycetes

Rfp3_Saccharomycetes

2

IPR016589

16,589

tRNA-splicing endonuclease, SEN2 subunit

tRNA_splic_SEN2

Family

2,573

false

This entry represents one of the two catalytic subunits of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. In at least some cases, the tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end pr...

[ "GO:0000213", "GO:0006388", "GO:0000214" ]

[ "tRNA-intron lyase activity", "tRNA splicing, via endonucleolytic cleavage and ligation", "tRNA-intron endonuclease complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF011789" ]

[ "tRNA_splic_SEN2" ]

[ 2573 ]

1

[ "EC", "METACYC", "METACYC", "REACTOME" ]

[ "4.6.1.16", "PWY-6689", "PWY-7803", "R-HSA-6784531" ]

[ "EC:4.6.1.16", "METACYC:PWY-6689", "METACYC:PWY-7803", "REACTOME:R-HSA-6784531" ]

4

[ "7uxa", "7zrz", "8hmy", "8hmz", "8iss" ]

5

[ "PUB00044697" ]

[ "15109492" ]

[ "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation." ]

[ 2004 ]

1

[ "IPR006676" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2573 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 19, 1, 3, 1, 1 ]

6

true

Family

tRNA-splicing endonuclease, SEN2 subunit

tRNA_splic_SEN2

8

IPR016590

16,590

Rhamnogalacturonase B

Rhamnogalacturonase_B

Family

2,045

false

This entry represents rhamnogalacturonase B, a pectinolytic enzyme (endolyase; ) that hydrolyses the alpha-L-rhamnopyranosyl-(1,4)-alpha-D-galacturonopyranosyl glycosidic linkage by beta-elimination, thereby generating oligosaccharides terminating at the non-reducing end with a hex-4-enopyranosyluronic acid residue [ ]...

[ "GO:0016837", "GO:0005975" ]

[ "carbon-oxygen lyase activity, acting on polysaccharides", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF011794", "PTHR36574" ]

[ "Rhamnogalacturonase_B", "" ]

[ 692, 2045 ]

2

[ "EC", "METACYC" ]

[ "4.2.2.23", "PWY-6771" ]

[ "EC:4.2.2.23", "METACYC:PWY-6771" ]

2

[ "1nkg", "2xhn", "3njv", "3njx" ]

4

[ "PUB00042682" ]

[ "8587995" ]

[ "Rhamnogalacturonase B from Aspergillus aculeatus is a rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-->4)-alpha-D-galactopyranosyluronide lyase." ]

[ 1996 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "human gut metagenome" ]

[ 508, 1536, 1 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Rhamnogalacturonase B

Rhamnogalacturonase_B

7

IPR016591

16,591

Suppressor of fused, eukaryotic

Suppressor_of_fused_euk

Family

1,786

false

Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling [ ]. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [ ], and functions by binding these proteins and preventing their translocation...

[ "GO:0008134" ]

[ "transcription factor binding" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF011844" ]

[ "Suppressor_of_fused_protein" ]

[ 1786 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5610780", "R-HSA-5610783", "R-HSA-5610785", "R-HSA-5610787", "R-HSA-5632684", "R-MMU-5610780", "R-MMU-5610785", "R-MMU-5610787", "R-MMU-5632684" ]

[ "REACTOME:R-HSA-5610780", "REACTOME:R-HSA-5610783", "REACTOME:R-HSA-5610785", "REACTOME:R-HSA-5610787", "REACTOME:R-HSA-5632684", "REACTOME:R-MMU-5610780", "REACTOME:R-MMU-5610785", "REACTOME:R-MMU-5610787", "REACTOME:R-MMU-5632684" ]

9

[ "1m1l", "4km8", "4km9", "4kma", "4kmd", "4kmh", "6lph" ]

7

[ "PUB00010225", "PUB00010226", "PUB00101143" ]

[ "12150819", "12068298", "28965847" ]

[ "Medulloblastoma: a problem of developmental biology.", "Mutations in SUFU predispose to medulloblastoma.", "Hypomorphic Recessive Variants in SUFU Impair the Sonic Hedgehog Pathway and Cause Joubert Syndrome with Cranio-facial and Skeletal Defects." ]

[ 2002, 2002, 2017 ]

3

[ "IPR007768" ]

[]

1

0

1

[ "Bacteria", "Metazoa" ]

[ 19, 1767 ]

2

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 2, 3, 4, 4 ]

5

true

Family

Suppressor of fused, eukaryotic

Suppressor_of_fused_euk

1

IPR016592

16,592

Nibrin

Nibrin_met

Family

1,038

false

Nibrin (also known as Nbs1 or p95) plays an important role in the DNA damage response (DDR) and DNA repair. It is part of the nuclear MRN complex, which consists of Mre11, Rad50, and Nbs1, and is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint co...

[ "GO:0000723", "GO:0006281", "GO:0006974", "GO:0007093", "GO:0005634", "GO:0030870" ]

[ "telomere maintenance", "DNA repair", "DNA damage response", "mitotic cell cycle checkpoint signaling", "nucleus", "Mre11 complex" ]

[ "biological_process", "biological_process", "biological_process", "biological_process", "cellular_component", "cellular_component" ]

6

[ "PIRSF" ]

[ "PIRSF011869" ]

[ "Nibrin_animal" ]

[ 1038 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DRE-5693548", "R-GGA-217106", "R-GGA-351433", "R-GGA-351442", "R-GGA-351444", "R-HSA-2559586", "R-HSA-5685938", "R-HSA-5685939", "R-HSA-5685942", "R-HSA-5693548", "R-HSA-5693554", "R-HSA-5693565", "R-HSA-5693568", "R-HSA-5693571", "R-HSA-5693579", "R-HSA-5693607", "R-HSA-5693616",...

[ "REACTOME:R-DRE-5693548", "REACTOME:R-GGA-217106", "REACTOME:R-GGA-351433", "REACTOME:R-GGA-351442", "REACTOME:R-GGA-351444", "REACTOME:R-HSA-2559586", "REACTOME:R-HSA-5685938", "REACTOME:R-HSA-5685939", "REACTOME:R-HSA-5685942", "REACTOME:R-HSA-5693548", "REACTOME:R-HSA-5693554", "REACTOME:R-...

51

[ "8bah", "9q9i", "9q9j", "9q9m" ]

4

[ "PUB00062775", "PUB00073633", "PUB00073634", "PUB00073635", "PUB00073636", "PUB00073637", "PUB00073638", "PUB00073639" ]

[ "9705271", "22373003", "25119968", "12422221", "10888888", "19759395", "15668383", "11448772" ]

[ "Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.", "Nijmegen breakage syndrome (NBS).", "The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes.", "Nbs1 is essential for DNA repair by homo...

[ 1998, 2012, 2014, 2002, 2000, 2009, 2005, 2001 ]

8

[ "IPR040227" ]

[]

1

0

1

[ "Bilateria" ]

[ 1038 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 2, 12, 2, 4 ]

5

true

Family

Nibrin

Nibrin_met

3

IPR016593

16,593

Adenovirus 41, E3-31.6kDa

Adenovirus-41_E3-31.6kDa

Family

49

false

This entry is represented by human adenovirus 41, E3-31.6kDa; it is a family of uncharacterised viral proteins.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27706", "PIRSF012150" ]

[ "Adenovirus-41_E3", "UCP012150" ]

[ 49, 16 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Mastadenovirus" ]

[ 49 ]

1

[]

0

true

Family

Adenovirus 41, E3-31.6kDa

Adenovirus-41_E3-31.6kDa

7

IPR016594

16,594

Bacteriophage T4 Inh

Inh_T4

Family

266

false

Bacteriophage T4 inhibitor (Inh) protein functions as an inhibitor of the prohead protease gp21. The inh gene is located upstream of the hoc gene in the T4 genome. The protein is approximately 226 amino acids long and acts as a minor capsid protein in phage T4.

[]

0

[ "PIRSF" ]

[ "PIRSF012159" ]

[ "Inh_gp21_prd" ]

[ 266 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Viruses" ]

[ 266 ]

1

[]

0

true

Family

Bacteriophage T4 Inh

Inh_T4

2

IPR016595

16,595

Surface-adhesin protein E, Pasteurellaceae

Adhesin_E_Pasteurellaceae

Family

87

false

This entry represents the surface-adhesin protein E from Pasteurellaceae. Adhesin E plays a role in pathogenesis [ ]. It binds to host proteins including plasminogen, vitronectin and laminin [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF012320" ]

[ "Prplsmic_HI0178_prd" ]

[ 87 ]

1

[]

0

[ "3zh5", "3zh6", "3zh7", "6gus" ]

4

[ "PUB00076136", "PUB00076137" ]

[ "19125675", "23275089" ]

[ "Nontypeable Haemophilus influenzae adhesin protein E: characterization and biological activity.", "The unique structure of Haemophilus influenzae protein E reveals multiple binding sites for host factors." ]

[ 2009, 2013 ]

2

[]

0

null

[ "Pasteurellaceae" ]

[ 87 ]

1

[]

0

true

Family

Surface-adhesin protein E, Pasteurellaceae

Adhesin_E_Pasteurellaceae

1

IPR016596

16,596

Protein of unknown function UCP012335

UCP012335

Family

528

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF012335" ]

[ "UCP012335" ]

[ 528 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "ecological metagenomes" ]

[ 521, 7 ]

2

[]

0

true

Family

Protein of unknown function UCP012335

UCP012335

8

IPR016597

16,597

Uncharacterised conserved protein UCP012359

UCP012359

Family

34

false

There is currently no experimental data to indicate the function of proteins in this family. Some family members appear to contain a merR-type HTH DNA-binding domain.

[]

0

[ "PIRSF" ]

[ "PIRSF012359" ]

[ "UCP012359" ]

[ 34 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Rickettsia" ]

[ 34 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP012359

UCP012359

9

IPR016598

16,598

Uncharacterised conserved protein UCP012467

UCP012467

Family

2

false

This group represents a uncharacterised conserved proteins from enterobacteriaceae.

[]

0

[ "PIRSF" ]

[ "PIRSF012467" ]

[ "UCP012467" ]

[ 2 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillus anthracis" ]

[ 2 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP012467

UCP012467

3

IPR016599

16,599

Uncharacterised conserved protein UCP012569

UCP012569

Family

621

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF012569" ]

[ "UCP012569" ]

[ 621 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota" ]

[ 621 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP012569

UCP012569

6

IPR016600

16,600

Uncharacterised conserved protein UCP012611

UCP012611

Family

97

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF012611" ]

[ "UCP012611" ]

[ 97 ]

1

[]

0

[]

0

[]

0

[ "IPR019238" ]

[]

1

0

1

[ "Bacteria" ]

[ 97 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP012611

UCP012611

8

IPR016601

16,601

Uncharacterised conserved protein UCP012637

UCP012637

Family

997

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF012637" ]

[ "UCP012637" ]

[ 997 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes", "freshwater metagenome" ]

[ 996, 1 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP012637

UCP012637

8

IPR016602

16,602

Uncharacterised conserved protein UCP012666

UCP012666

Family

4,005

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF012666" ]

[ "UCP012666" ]

[ 4005 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Halobacteriales", "metagenomes" ]

[ 3787, 199, 19 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP012666

UCP012666

8

IPR016604

16,604

Uncharacterised conserved protein UCP012886

UCP012886

Family

27

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF012886" ]

[ "UCP012886" ]

[ 27 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota" ]

[ 27 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP012886

UCP012886

2

IPR016605

16,605

High-affinity nitrate transporter

Transptr_NO3_Nar2

Family

1,128

false

This group represents a high affinity nitrate transporter component from plants. It includes high-affinity nitrate transporter 3.1 (NRT3.1 or NAR2.1) from Arabidopsis, which acts as a dual component transporter with NTR2 [ , ]. The functional unit for high-affinity nitrate influx may be a tetramer consisting of two sub...

[ "GO:0010167", "GO:0015706" ]

[ "response to nitrate", "nitrate transmembrane transport" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF16974", "PIRSF012939", "PTHR34806" ]

[ "NAR2", "Transpt_NO3_Nar2", "" ]

[ 1121, 879, 1097 ]

3

[]

0

[]

0

[ "PUB00071565", "PUB00071566", "PUB00071567", "PUB00071568", "PUB00071570" ]

[ "16415212", "17012411", "19704673", "20561257", "16998085" ]

[ "High-affinity nitrate transport in roots of Arabidopsis depends on expression of the NAR2-like gene AtNRT3.1.", "Characterization of a two-component high-affinity nitrate uptake system in Arabidopsis. Physiology and protein-protein interaction.", "Nitrate signaling and the two component high affinity uptake sy...

[ 2006, 2006, 2007, 2010, 2006 ]

5

[]

0

null

[ "Eukaryota" ]

[ 1128 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 7, 3, 7 ]

3

true

Family

High-affinity nitrate transporter

Transptr_NO3_Nar2

3

IPR016606

16,606

Uncharacterised conserved protein UCP012943, magnoliopsida

UCP012943_magno

Family

196

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF012943" ]

[ "UCP012943" ]

[ 196 ]

1

[]

0

[]

0

[]

0

[ "IPR060745" ]

[]

1

0

1

[ "Mesangiospermae" ]

[ 196 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 11, 8, 8 ]

3

true

Family

Uncharacterised conserved protein UCP012943, magnoliopsida

UCP012943_magno

7

IPR016607

16,607

Protein SCAI, metazoan/viridiplantae

SCAI_metazoan/Viridiplantae

Family

864

false

This entry represents protein SCAI from metazoans and plants. SCAI is a transcriptional cofactor and tumour suppressor that suppresses MKL1-induced SRF transcriptional activity. It may function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1 [ ].

[ "GO:0003714", "GO:0006351" ]

[ "transcription corepressor activity", "DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF013022" ]

[ "UCP013022" ]

[ 864 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-5663220", "R-MMU-5663220" ]

[ "REACTOME:R-HSA-5663220", "REACTOME:R-MMU-5663220" ]

2

[]

0

[ "PUB00068364" ]

[ "19350017" ]

[ "SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin." ]

[ 2009 ]

1

[ "IPR022709" ]

[]

1

0

1

[ "Eukaryota" ]

[ 864 ]

1

[ "Arabidopsis thaliana", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 7, 2, 1, 1, 4, 6, 1 ]

7

true

Family

Protein SCAI, metazoan/viridiplantae

SCAI_metazoan/Viridiplantae

1

IPR016608

16,608

PR domain zinc finger protein 1

PRDM1

Family

1,791

false

PR domain zinc finger protein 1 (PRDM1, also known as BLIMP-1) is a transcriptional repressor that is essential for cellular development. This entry includes BLIMP-1 from vertebrates and its homologues from invertebrates.

[ "GO:0001227", "GO:0048869" ]

[ "DNA-binding transcription repressor activity, RNA polymerase II-specific", "cellular developmental process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF013212" ]

[ "PRDM1" ]

[ 1791 ]

1

[ "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6804754", "R-HSA-9701898", "R-HSA-9827857" ]

[ "REACTOME:R-HSA-6804754", "REACTOME:R-HSA-9701898", "REACTOME:R-HSA-9827857" ]

3

[]

0

[ "PUB00071016", "PUB00071017", "PUB00071018" ]

[ "24968003", "24613396", "25015830" ]

[ "BLMP-1/Blimp-1 Regulates the Spatiotemporal Cell Migration Pattern in C. elegans.", "DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation.", "IL-2 Induction of Blimp-1 Is a Key In Vivo Signal for CD8+ Short-Lived Effector T Cell Differentiation." ]

[ 2014, 2014, 2014 ]

3

[ "IPR050331" ]

[]

1

0

1

[ "Eumetazoa" ]

[ 1791 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 15, 6, 2, 4 ]

4

true

Family

PR domain zinc finger protein 1

PRDM1

9

IPR016610

16,610

Exonuclease V, Saccharomyces

Exo5

Family

50

false

This entry represents Exo5 and matches mainly Saccharomyces proteins. In Saccharomyces cerevisiae (Baker's yeast), Exo5 is a single strand DNA specific 5'-exonuclease, which is involved in mitochondrial DNA replication and recombination. It has the capacity to slide across 5' double-stranded DNA or 5'RNA sequences and ...

[ "GO:0045145", "GO:0036297", "GO:0005739" ]

[ "single-stranded DNA 5'-3' DNA exonuclease activity", "interstrand cross-link repair", "mitochondrion" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF013220" ]

[ "UCP013220" ]

[ 50 ]

1

[]

0

[]

0

[ "PUB00062398", "PUB00066720" ]

[ "20086101", "3286646" ]

[ "Yeast exonuclease 5 is essential for mitochondrial genome maintenance.", "Exonuclease V from Saccharomyces cerevisiae. A 5'----3'-deoxyribonuclease that produces dinucleotides in a sequential fashion." ]

[ 2010, 1988 ]

2

[ "IPR019190" ]

[]

1

0

1

[ "saccharomyceta" ]

[ 50 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Family

Exonuclease V, Saccharomyces

Exo5

3

IPR016611

16,611

Mitochondrial intermembrane space cysteine motif-containing protein Mix14

Mix14

Family

54

false

Mix14 is a mitochondrial intermembrane space protein with unknown function [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF013232" ]

[ "UCP013232" ]

[ 54 ]

1

[]

0

[]

0

[ "PUB00074997" ]

[ "17095012" ]

[ "Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway." ]

[ 2007 ]

1

[]

0

null

[ "Opisthokonta" ]

[ 54 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Mitochondrial intermembrane space cysteine motif-containing protein Mix14

Mix14

1

IPR016613

16,613

Increased recombination centres protein 19, saccharomycetes

Irc19_saccharomycetes

Family

22

false

This entry represents Irc19 in Saccharomycetes. Irc19 is involved in sporulation and maintenance of the mitochondrial DNA [ , , ].

[ "GO:0030437" ]

[ "ascospore formation" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF013329" ]

[ "UCP013329" ]

[ 22 ]

1

[]

0

[]

0

[ "PUB00071556", "PUB00074953", "PUB00074954" ]

[ "19751518", "12432101", "11921089" ]

[ "Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae.", "Parallel phenotypic analysis of sporulation and postgermination growth in Saccharomyces cerevisiae.", "Systematic analysis of ...

[ 2009, 2002, 2002 ]

3

[ "IPR060746" ]

[]

1

0

1

[ "Saccharomycotina" ]

[ 22 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Increased recombination centres protein 19, saccharomycetes

Irc19_saccharomycetes

4

IPR016614

16,614

Mitochondrial holo-[acyl-carrier-protein] synthase Ppt2

PPTase_2

Family

13

false

Ppt2 is a phosphopantetheine:protein transferase (PPTase) that transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of mitochondrial acyl-carrier-protein [ ].

[ "GO:0008897", "GO:0005739" ]

[ "holo-[acyl-carrier-protein] synthase activity", "mitochondrion" ]

[ "molecular_function", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF013370" ]

[ "ACPS_fun" ]

[ 13 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "2.7.8.7", "PWY-6012", "PWY-6289" ]

[ "EC:2.7.8.7", "METACYC:PWY-6012", "METACYC:PWY-6289" ]

3

[]

0

[ "PUB00074940" ]

[ "9712852" ]

[ "A novel phosphopantetheine:protein transferase activating yeast mitochondrial acyl carrier protein." ]

[ 1998 ]

1

[]

0

null

[ "Saccharomycetaceae" ]

[ 13 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1 ]

1

true

Family

Mitochondrial holo-[acyl-carrier-protein] synthase Ppt2

PPTase_2

1

IPR016615

16,615

Ubiquitin thioesterase Otubain

Otubain

Family

1,949

false

Otubain family members include OTUB1, OTUB2 from mammals and otubain-like proteins from insects, worms and plants. They are a group of deubiquitylating enzymes that can remove conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation [ ]. A cyst...

[ "GO:0016787", "GO:0016579" ]

[ "hydrolase activity", "protein deubiquitination" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF013503" ]

[ "Ubiquitin_thioesterase_Otubain" ]

[ 1949 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.19.12", "R-CEL-5689896", "R-DME-5689880", "R-DME-5689896", "R-HSA-5689880", "R-HSA-5689896", "R-MMU-5689880", "R-MMU-5689896", "R-RNO-5689880", "R-RNO-5689896" ]

[ "EC:3.4.19.12", "REACTOME:R-CEL-5689896", "REACTOME:R-DME-5689880", "REACTOME:R-DME-5689896", "REACTOME:R-HSA-5689880", "REACTOME:R-HSA-5689896", "REACTOME:R-MMU-5689880", "REACTOME:R-MMU-5689896", "REACTOME:R-RNO-5689880", "REACTOME:R-RNO-5689896" ]

10

[ "1tff", "2zfy", "3von", "4dhi", "4dhj", "4dhz", "4fjv", "4i6l", "4ldt", "5qio", "5qip", "5qiq", "5qir", "5qis", "5qit", "5qiu", "5qiv", "5qiw", "5qix", "5qiy", "5qiz", "6k9n", "6k9p", "6kbe", "8cms" ]

25

[ "PUB00011704", "PUB00020025", "PUB00030423", "PUB00045069", "PUB00076953" ]

[ "11517925", "9891971", "14725770", "12704427", "7044372" ]

[ "Evolutionary lines of cysteine peptidases.", "Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.", "The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall.", ...

[ 2001, 1998, 2004, 2003, 1982 ]

5

[ "IPR019400" ]

[]

1

0

1

[ "Eukaryota", "bird metagenome" ]

[ 1948, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 2, 1, 2, 1, 6, 3, 2, 6, 1 ]

9

true

Family

Ubiquitin thioesterase Otubain

Otubain

8

IPR016616

16,616

Bardet-Biedl syndrome 2 protein

Bardet-Biedl_syndrome_2_prot

Family

2,456

false

This entry represents BBS2, which is required for leptin receptor signalling in the hypothalamus [ ]. BBS2 and 4 are also required for the localisation of somatostatin receptor 3 and melanin-concentrating hormone receptor 1 into neuronal cilia [ ]. Bardet-Biedl syndrome is a member of genetic ciliopathies, but the link...

[ "GO:1905515", "GO:0034464" ]

[ "non-motile cilium assembly", "BBSome" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF013684", "PTHR32465" ]

[ "BBS2", "" ]

[ 1486, 2456 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-5620922", "R-HSA-5620922", "R-MMU-5620922", "R-RNO-5620922" ]

[ "REACTOME:R-CEL-5620922", "REACTOME:R-HSA-5620922", "REACTOME:R-MMU-5620922", "REACTOME:R-RNO-5620922" ]

4

[ "6vbu", "6vbv", "6vnw", "6voa" ]

4

[ "PUB00043590", "PUB00043591", "PUB00043592", "PUB00043593", "PUB00070006" ]

[ "18506366", "18317593", "18334641", "18032602", "19150989" ]

[ "Regulation of Alstrom syndrome gene expression during adipogenesis and its relationship with fat cell insulin sensitivity.", "Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome.", "Bardet-Biedl syndrome proteins are required for the localization of G protein-coup...

[ 2008, 2008, 2008, 2007, 2009 ]

5

[]

0

null

[ "Dictyobacter arantiisoli", "Eukaryota", "hydrothermal vent metagenome" ]

[ 1, 2454, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 31, 2, 3 ]

5

true

Family

Bardet-Biedl syndrome 2 protein

Bardet-Biedl_syndrome_2_prot

9

IPR016618

16,618

Uncharacterised conserved protein UCP014422

UCP014422

Family

271

false

This entry represents uncharacterised proteins found in bacteria and archaea. These proteins contain an α/β fold.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27709", "PIRSF014422" ]

[ "UCP014422", "UCP014422" ]

[ 271, 129 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 121, 148, 2 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP014422

UCP014422

3

IPR016619

16,619

Uncharacterised conserved protein UCP014439, ACT

UCP014439_ACT

Family

66

false

This group represents an uncharacterised protein with ACT domain including found in archaea.

[]

0

[ "PIRSF" ]

[ "PIRSF014439" ]

[ "APE1894_ACT" ]

[ 66 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Candidatus Nomuraibacteriota", "mine drainage metagenome" ]

[ 63, 2, 1 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP014439, ACT

UCP014439_ACT

2

IPR016620

16,620

CRISPR system ring nuclease SSO1393

SSO1393

Family

14

false

This entry represents a family of archaeal proteins, including CRISPR system ring nuclease SSO1393 from Sulfolobus solfataricus ( ). SSO1393 has been described as a component of the CRISPR system [ ]. CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection...

[]

0

[ "NCBIFAM", "PIRSF" ]

[ "NF040951", "PIRSF014470" ]

[ "CRSPR_nucase", "UCP014470" ]

[ 12, 14 ]

2

[]

0

[ "3qyf" ]

1

[ "PUB00091682", "PUB00154244" ]

[ "30232454", "30444997" ]

[ "Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate.", "If You'd Like to Stop a Type III CRISPR Ribonuclease, Then You Should Put a Ring (Nuclease) on It." ]

[ 2018, 2018 ]

2

[]

0

null

[ "Thermoprotei" ]

[ 14 ]

1

[]

0

true

Family

CRISPR system ring nuclease SSO1393

SSO1393

2

IPR016622

16,622

Bacteriophage SP-beta, YorJ

Phage_SP-beta_YorJ

Family

29

false

This entry is represented by Bacteriophage SP-beta, YorJ. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are...

[]

0

[ "NCBIFAM", "PIRSF" ]

[ "NF006382", "PIRSF014669" ]

[ "PRK08624.1", "UCP014669" ]

[ 29, 25 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "Bacillus phage SPbeta" ]

[ 28, 1 ]

2

[]

0

true

Family

Bacteriophage SP-beta, YorJ

Phage_SP-beta_YorJ

3

IPR016624

16,624

Uncharacterised conserved protein UCP014753

UCP014753

Family

7,222

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF014753", "PTHR35339" ]

[ "UCP014753", "" ]

[ 5769, 7222 ]

2

[]

0

[ "8oi4", "9nwf", "9o4u" ]

3

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 5245, 1898, 51, 28 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Uncharacterised conserved protein UCP014753

UCP014753

9

IPR016625

16,625

Uncharacterised conserved protein UCP014872, subtilisin-related

UCP014872_subtilisin-rel

Family

99

false

This group represents uncharacterised conserved proteins related to the subtilisins.

[]

0

[ "PIRSF" ]

[ "PIRSF014872" ]

[ "UCP014872" ]

[ 99 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanophyceae" ]

[ 99 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP014872, subtilisin-related

UCP014872_subtilisin-rel

5

IPR016627

16,627

Uncharacterised conserved protein UCP015013

UCP015013

Family

12

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF015013" ]

[ "UCP015013" ]

[ 12 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Stenosarchaea group" ]

[ 2, 10 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP015013

UCP015013

3

IPR016628

16,628

ATPase, SAG2001, predicted

ATPase_SAG2001_prd

Family

1,850

false

This group represents a predicted ATPase, SAG2001 type.

[]

0

[ "PIRSF" ]

[ "PIRSF015040" ]

[ "ATPase_SAG2001_prd" ]

[ 1850 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Streptococcus phage IPP61", "bioreactor metagenome" ]

[ 1848, 1, 1 ]

3

[]

0

true

Family

ATPase, SAG2001, predicted

ATPase_SAG2001_prd

7

IPR016629

16,629

TATA box-binding protein-associated factor RNA polymerase I subunit A, chordata

RNA_pol_I_TAF1A/TAFI48_chr

Family

120

false

This entry represents subunit A (TATA-binding protein-associated factor TAFI48 or TAF1A) of RNA polymerase I. It is a component of the transcription factor SL1/TIFIB complex involved in the assembly of the pre-initiation complex (PIC). The SL1/TIFIB complex is composed of TBP (TATA-binding protein) and TAF1A (TAFI48), ...

[ "GO:0006360", "GO:0000120" ]

[ "transcription by RNA polymerase I", "RNA polymerase I transcription regulator complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF015161" ]

[ "TAFI48" ]

[ 120 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-427359", "R-HSA-427413", "R-HSA-5250924", "R-HSA-73762", "R-HSA-73772", "R-HSA-73863", "R-MMU-5250924", "R-MMU-73762", "R-MMU-73772", "R-MMU-73863", "R-RNO-5250924", "R-RNO-73762", "R-RNO-73772", "R-RNO-73863" ]

[ "REACTOME:R-HSA-427359", "REACTOME:R-HSA-427413", "REACTOME:R-HSA-5250924", "REACTOME:R-HSA-73762", "REACTOME:R-HSA-73772", "REACTOME:R-HSA-73863", "REACTOME:R-MMU-5250924", "REACTOME:R-MMU-73762", "REACTOME:R-MMU-73772", "REACTOME:R-MMU-73863", "REACTOME:R-RNO-5250924", "REACTOME:R-RNO-73762"...

14

[]

0

[ "PUB00042708", "PUB00042709", "PUB00088436" ]

[ "17318177", "7491500", "15970593" ]

[ "A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription.", "Coactivator and promoter-selective properties of RNA polymerase I TAFs.", "TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter." ]

[ 2007, 1995, 2005 ]

3

[ "IPR039495" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 120 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 2, 3, 3 ]

4

true

Family

TATA box-binding protein-associated factor RNA polymerase I subunit A, chordata

RNA_pol_I_TAF1A/TAFI48_chr

9

IPR016630

16,630

Uncharacterised conserved protein UCP015278

UCP015278

Family

463

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10004", "PIRSF015278" ]

[ "DUF2247", "UCP015278" ]

[ 463, 221 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "mine drainage metagenome" ]

[ 462, 1 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP015278

UCP015278

5

IPR016631

16,631

Regulatory, RpfE

Regulatory_RpfE

Family

1,376

false

This group represents a regulatory protein, RpfE type.

[]

0

[ "PIRSF" ]

[ "PIRSF015283" ]

[ "Regulatory_RpfE" ]

[ 1376 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "ecological metagenomes" ]

[ 1365, 11 ]

2

[]

0

true

Family

Regulatory, RpfE

Regulatory_RpfE

6

IPR016632

16,632

Conserved oligomeric Golgi complex subunit 8, Metazoal and Viridiplantae

COG8_Metazoal_Plant

Family

1,305

false

This entry represents conserved oligomeric Golgi complex subunit 8 from metazoans and viridiplantae. It is a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking [ ].

[ "GO:0017119" ]

[ "Golgi transport complex" ]

[ "cellular_component" ]

1

[ "PIRSF" ]

[ "PIRSF015415" ]

[ "COG8" ]

[ 1305 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DME-6807878", "R-DME-6811438", "R-DME-6811440", "R-HSA-6807878", "R-HSA-6811438", "R-HSA-6811440", "R-MMU-6807878", "R-MMU-6811438", "R-MMU-6811440" ]

[ "REACTOME:R-DME-6807878", "REACTOME:R-DME-6811438", "REACTOME:R-DME-6811440", "REACTOME:R-HSA-6807878", "REACTOME:R-HSA-6811438", "REACTOME:R-HSA-6811440", "REACTOME:R-MMU-6807878", "REACTOME:R-MMU-6811438", "REACTOME:R-MMU-6811440" ]

9

[]

0

[ "PUB00009854" ]

[ "11703943" ]

[ "The Sec34/35 Golgi transport complex is related to the exocyst, defining a family of complexes involved in multiple steps of membrane traffic." ]

[ 2001 ]

1

[ "IPR007255" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1305 ]

1

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 4, 1, 1, 3, 3, 2, 2, 7 ]

8

true

Family

Conserved oligomeric Golgi complex subunit 8, Metazoal and Viridiplantae

COG8_Metazoal_Plant

3

IPR016633

16,633

Protein-arginine rhamnosyltransferase EarP

EarP

Family

2,879

false

This entry includes family members such as EarP enzymes which are essential for post-translational activation of elongation factor P (EF-P). It was identified as EF-P arginine R32 specific rhamnosyl transferase in Shewanella oneidensis using dTDP-beta-L-rhamnose as donor substrate [ ]. This was further confirmed for Ps...

[ "GO:0106361" ]

[ "protein-arginine rhamnosyltransferase activity" ]

[ "molecular_function" ]

1

[ "PFAM", "PIRSF", "NCBIFAM" ]

[ "PF10093", "PIRSF015557", "TIGR03837" ]

[ "EarP", "UCP015557", "efp_Arg_rhamno" ]

[ 2879, 2589, 2662 ]

3

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "2.4.1.-", "PWY-1901", "PWY-1961", "PWY-1981", "PWY-2021", "PWY-2881", "PWY-2901", "PWY-2902", "PWY-4421", "PWY-4801", "PWY-5094", "PWY-5105", "PWY-5129", "PWY-5139", "PWY-5160", "PWY-5161", "PWY-5268", "PWY-5284", "PWY-5286", "PWY-5310", "PWY-5312", "PWY-5313", "PWY-5317...

[ "EC:2.4.1.-", "METACYC:PWY-1901", "METACYC:PWY-1961", "METACYC:PWY-1981", "METACYC:PWY-2021", "METACYC:PWY-2881", "METACYC:PWY-2901", "METACYC:PWY-2902", "METACYC:PWY-4421", "METACYC:PWY-4801", "METACYC:PWY-5094", "METACYC:PWY-5105", "METACYC:PWY-5129", "METACYC:PWY-5139", "METACYC:PWY-5...

200

[ "5nv8", "5wxi", "5wxj", "5wxk", "5xvr", "6j7j", "6j7k", "6j7l", "6j7m", "7cox", "7f2a", "7vch" ]

12

[ "PUB00091040", "PUB00091041", "PUB00091042", "PUB00091043", "PUB00091044", "PUB00091045", "PUB00097941" ]

[ "25686373", "26060278", "28951478", "26840407", "28451135", "28451332", "31010899" ]

[ "Arginine-rhamnosylation as new strategy to activate translation elongation factor P.", "Cyclic Rhamnosylated Elongation Factor P Establishes Antibiotic Resistance in Pseudomonas aeruginosa.", "Structural Basis for EarP-Mediated Arginine Glycosylation of Translation Elongation Factor EF-P.", "Neisseria mening...

[ 2015, 2015, 2017, 2016, 2016, 2017, 2019 ]

7

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 2851, 3, 25 ]

3

[]

0

true

Family

Protein-arginine rhamnosyltransferase EarP

EarP

1

IPR016634

16,634

DNA-binding transcriptional repressor CapW-like

CapW-like

Family

2,694

false

This entry represents DNA-binding transcriptional repressor CapW from Escherichia coli and similar WYL domain containing proteins mainly found in proteobacteria. CapW is a transcriptional regulator of a CBASS (cyclic oligonucleotide-based antiphage signaling system) antivirus system that provides immunity against bacte...

[]

0

[ "PIRSF" ]

[ "PIRSF015558" ]

[ "Txn_reg_DeoR_prd" ]

[ 2694 ]

1

[]

0

[ "7qfz", "7t8k", "7t8l", "7tb5", "7tb6", "9c5g" ]

6

[ "PUB00153145" ]

[ "35536256" ]

[ "Control of bacterial immune signaling by a WYL domain transcription factor." ]

[ 2022 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "IncJ plasmid R391", "metagenomes" ]

[ 2664, 3, 1, 26 ]

4

[]

0

true

Family

DNA-binding transcriptional repressor CapW-like

CapW-like

4

IPR016635

16,635

Adaptor protein complex, sigma subunit

AP_complex_ssu

Family

20,610

false

The adaptor protein complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules [ ]. Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit ...

[ "GO:0015031" ]

[ "protein transport" ]

[ "biological_process" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF015588", "PTHR11753" ]

[ "AP_complex_sigma", "" ]

[ 15025, 20610 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-177504", "R-BTA-2132295", "R-BTA-416993", "R-BTA-432720", "R-BTA-432722", "R-BTA-437239", "R-BTA-5099900", "R-BTA-5140745", "R-BTA-8856825", "R-BTA-8856828", "R-BTA-8866427", "R-BTA-8964038", "R-DDI-432720", "R-DDI-437239", "R-DDI-8856825", "R-DDI-8856828", "R-DDI-8866427", ...

[ "REACTOME:R-BTA-177504", "REACTOME:R-BTA-2132295", "REACTOME:R-BTA-416993", "REACTOME:R-BTA-432720", "REACTOME:R-BTA-432722", "REACTOME:R-BTA-437239", "REACTOME:R-BTA-5099900", "REACTOME:R-BTA-5140745", "REACTOME:R-BTA-8856825", "REACTOME:R-BTA-8856828", "REACTOME:R-BTA-8866427", "REACTOME:R-B...

69

[ "1w63", "2jkr", "2jkt", "2vgl", "2xa7", "4hmy", "4nee", "4p6z", "4uqi", "6cm9", "6cri", "6d83", "6d84", "6dff", "6owo", "6owt", "6oxl", "6qh5", "6qh6", "6qh7", "6uri", "6yae", "6yaf", "6yah", "7og1", "7oho", "7p3x", "7p3y", "7p3z", "7r4h", "7rw8", "7rw9"...

54

[ "PUB00096960" ]

[ "23424177" ]

[ "The clathrin adaptor complexes as a paradigm for membrane-associated allostery." ]

[ 2013 ]

1

[]

[ "IPR027155", "IPR027156", "IPR044733" ]

0

3

0

[ "Eukaryota", "Shewanella electrica", "bird metagenome" ]

[ 20608, 1, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 18, 3, 26, 8, 52, 27, 3, 22, 37, 3, 3, 46 ]

12

true

Family

Adaptor protein complex, sigma subunit

AP_complex_ssu

2

IPR016636

16,636

3-oxo-5-alpha-steroid 4-dehydrogenase

3-oxo-5-alpha-steroid_4-DH

Family

3,166

false

Synonym(s): Steroid 5-alpha-reductase 3-oxo-5-alpha-steroid 4-dehydrogenases, catalyse the conversion of 3-oxo-5-alpha-steroid + acceptor to 3-oxo-delta(4)-steroid + reduced acceptor. The steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation ...

[ "GO:0003865", "GO:0008202", "GO:0016020" ]

[ "3-oxo-5-alpha-steroid 4-dehydrogenase activity", "steroid metabolic process", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF015596" ]

[ "5_alpha-SR2" ]

[ 3166 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.3.1.22", "PWY-2582", "PWY-6032", "PWY-699", "PWY-7455", "PWY-8200", "PWY-8202", "R-BTA-193048", "R-HSA-193048", "R-MMU-193048", "R-RNO-193048", "R-SPO-193048", "R-SSC-193048" ]

[ "EC:1.3.1.22", "METACYC:PWY-2582", "METACYC:PWY-6032", "METACYC:PWY-699", "METACYC:PWY-7455", "METACYC:PWY-8200", "METACYC:PWY-8202", "REACTOME:R-BTA-193048", "REACTOME:R-HSA-193048", "REACTOME:R-MMU-193048", "REACTOME:R-RNO-193048", "REACTOME:R-SPO-193048", "REACTOME:R-SSC-193048" ]

13

[ "7bw1", "7c83" ]

2

[ "PUB00007121", "PUB00100738", "PUB00100739" ]

[ "1686016", "22822057", "32146811" ]

[ "Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue.", "CYP90A1/CPD, a brassinosteroid biosynthetic cytochrome P450 of Arabidopsis, catalyzes C-3 oxidation.", "Establishment of Biosynthetic Pathways To Generate Castasterone as the...

[ 1991, 2012, 2020 ]

3

[ "IPR039357" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "Promethearchaeati", "unclassified sequences" ]

[ 652, 2491, 6, 17 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea...

[ 2, 3, 6, 2, 3, 1, 7, 4, 1, 2 ]

10

true

Family

3-oxo-5-alpha-steroid 4-dehydrogenase

3-oxo-5-alpha-steroid_4-DH

5

IPR016637

16,637

Neurogenic differentiation factor NeuroD

TF_bHLH_NeuroD

Family

2,468

false

NeuroD is a group of basic helix-loop-helix transcription factors.They mediate neuronal differentiation [ , ].

[ "GO:0006355", "GO:0007399" ]

[ "regulation of DNA-templated transcription", "nervous system development" ]

[ "biological_process", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF015618" ]

[ "bHLH_NeuroD" ]

[ 2468 ]

1

[ "REACTOME", "REACTOME" ]

[ "R-HSA-210745", "R-HSA-210746" ]

[ "REACTOME:R-HSA-210745", "REACTOME:R-HSA-210746" ]

2

[]

0

[ "PUB00076574", "PUB00076575" ]

[ "15797719", "9078430" ]

[ "Context-dependent regulation of NeuroD activity and protein accumulation.", "NeuroD and neurogenesis." ]

[ 2005, 1997 ]

2

[]

0

null

[ "Gnathostomata" ]

[ 2468 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 9, 10, 9, 7 ]

4

true

Family

Neurogenic differentiation factor NeuroD

TF_bHLH_NeuroD

7

IPR016638

16,638

Uncharacterised protein family UPF0376

UPF0376

Family

276

false

This entry represents a group of uncharacterised proteins found in Caenorhabditis spp. This entry includes Excretory canal abnormal exc-13 from Caenorhabditis elegans ( ).

[]

0

[ "PIRSF" ]

[ "PIRSF015697" ]

[ "UCP015697" ]

[ 276 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Caenorhabditis" ]

[ 276 ]

1

[ "Caenorhabditis elegans" ]

[ 41 ]

1

true

Family

Uncharacterised protein family UPF0376

UPF0376

4

IPR016641

16,641

Nascent polypeptide-associated complex subunit alpha-like

EGD2/NACA0like

Family

8,291

false

In Saccharomyces cerevisiae, nascent polypeptide-associated complex subunit alpha (also known as EGD2) is a component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure app...

[ "GO:0005854" ]

[ "nascent polypeptide-associated complex" ]

[ "cellular_component" ]

1

[ "PANTHER" ]

[ "PTHR21713" ]

[ "" ]

[ 8291 ]

1

[]

0

[ "3lkx", "3mcb", "3mce", "6t59", "7qwq", "7qwr", "7qws", "8p2k", "9f1b", "9f1c", "9f1d", "9fq0", "9mr4", "9ndp", "9qqa", "9qqb" ]

16

[ "PUB00006566", "PUB00063125", "PUB00063126", "PUB00063127", "PUB00063128" ]

[ "10518932", "9482879", "10512867", "9877153", "8698236" ]

[ "The nascent polypeptide-associated complex (NAC) of yeast functions in the targeting process of ribosomes to the ER membrane.", "The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo.", "Nascent polypeptide-associated complex stimulates protein import into yeast m...

[ 1999, 1998, 1999, 1998, 1996 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 7, 69, 8207, 2, 6 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 19, 1, 6, 4, 14, 4, 1, 14, 15, 1, 1, 22 ]

12

true

Family

Nascent polypeptide-associated complex subunit alpha-like

EGD2/NACA0like

8

IPR016642

16,642

26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit

26S_Psome_Rpn2

Family

4,592

false

This group represents a 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit. Intracellular proteins, including short-lived proteins such as cyclin, Mos, Myc, p53, NF-kappaB, and IkappaB, are degraded by the ubiquitin-proteasome system. The 26S proteasome is a self-compartmentalising protease re...

[ "GO:0030234", "GO:0042176", "GO:0000502" ]

[ "enzyme regulator activity", "regulation of protein catabolic process", "proteasome complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF015947" ]

[ "26S_Psome_Rpn2" ]

[ 4592 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-1234176", "R-CEL-1236978", "R-CEL-187577", "R-CEL-195253", "R-CEL-349425", "R-CEL-350562", "R-CEL-382556", "R-CEL-4608870", "R-CEL-4641258", "R-CEL-5632684", "R-CEL-5687128", "R-CEL-5689603", "R-CEL-5689880", "R-CEL-6798695", "R-CEL-68949", "R-CEL-69017", "R-CEL-69601", "R-C...

[ "REACTOME:R-CEL-1234176", "REACTOME:R-CEL-1236978", "REACTOME:R-CEL-187577", "REACTOME:R-CEL-195253", "REACTOME:R-CEL-349425", "REACTOME:R-CEL-350562", "REACTOME:R-CEL-382556", "REACTOME:R-CEL-4608870", "REACTOME:R-CEL-4641258", "REACTOME:R-CEL-5632684", "REACTOME:R-CEL-5687128", "REACTOME:R-C...

296

[ "3jco", "3jcp", "4ady", "4cr2", "4cr3", "4cr4", "5a5b", "5gjq", "5gjr", "5l4k", "5ln3", "5m32", "5mpb", "5mpc", "5mpd", "5mpe", "5t0c", "5t0g", "5t0h", "5t0i", "5t0j", "5vfp", "5vfq", "5vfr", "5vfs", "5vft", "5vfu", "5vgz", "5vhf", "5vhh", "5vhi", "5vhs"...

111

[ "PUB00016866", "PUB00034667", "PUB00034668", "PUB00043308", "PUB00086026" ]

[ "15571806", "15890341", "9741626", "16566573", "28583440" ]

[ "The proteasome: a proteolytic nanomachine of cell regulation and waste disposal.", "Proteasome plasticity.", "A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.", "Effects of tumor necrosis factor-alpha on the 26S prot...

[ 2004, 2005, 1998, 2006, 2017 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4592 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 8, 1, 2, 3, 15, 6, 1, 5, 7, 1, 1, 23 ]

12

true

Family

26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit

26S_Psome_Rpn2

7

IPR016643

16,643

26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit

26S_Psome_Rpn1

Family

4,695

false

Intracellular proteins, including short-lived proteins such as cyclin, Mos, Myc, p53, NF-kappaB, and IkappaB, are degraded by the ubiquitin-proteasome system. The 26S proteasome is a self-compartmentalising protease responsible for the regulated degradation of intracellular proteins in eukaryotes [ , ]. This giant intr...

[ "GO:0030234", "GO:0042176", "GO:0000502" ]

[ "enzyme regulator activity", "regulation of protein catabolic process", "proteasome complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF015965" ]

[ "26S_Psome_Rpn1" ]

[ 4695 ]

1

[ "GP", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "GenProp2012", "R-BTA-1169091", "R-BTA-1234176", "R-BTA-1236978", "R-BTA-174084", "R-BTA-174154", "R-BTA-174178", "R-BTA-174184", "R-BTA-187577", "R-BTA-195253", "R-BTA-202424", "R-BTA-2467813", "R-BTA-2871837", "R-BTA-349425", "R-BTA-350562", "R-BTA-382556", "R-BTA-450408", "R-BTA...

[ "GP:GenProp2012", "REACTOME:R-BTA-1169091", "REACTOME:R-BTA-1234176", "REACTOME:R-BTA-1236978", "REACTOME:R-BTA-174084", "REACTOME:R-BTA-174154", "REACTOME:R-BTA-174178", "REACTOME:R-BTA-174184", "REACTOME:R-BTA-187577", "REACTOME:R-BTA-195253", "REACTOME:R-BTA-202424", "REACTOME:R-BTA-2467813...

268

[ "3jco", "3jcp", "4cr2", "4cr3", "4cr4", "5a5b", "5gjq", "5gjr", "5l4k", "5ln3", "5mpb", "5mpc", "5mpd", "5mpe", "5t0c", "5t0g", "5t0h", "5t0i", "5t0j", "5vfp", "5vfq", "5vfr", "5vfs", "5vft", "5vfu", "5vhf", "5vhh", "5vhi", "5vhj", "5vhm", "5vhn", "5vho"...

116

[ "PUB00016866", "PUB00034667", "PUB00034668", "PUB00043307", "PUB00043308", "PUB00086026" ]

[ "15571806", "15890341", "9741626", "1242268", "16566573", "28583440" ]

[ "The proteasome: a proteolytic nanomachine of cell regulation and waste disposal.", "Proteasome plasticity.", "A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.", "Critical analysis of methods for estimating production...

[ 2004, 2005, 1998, 1975, 2006, 2017 ]

6

[]

0

null

[ "Eukaryota" ]

[ 4695 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 1, 1, 1, 3, 8, 1, 9, 2, 1, 1, 6 ]

12

true

Family

26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit

26S_Psome_Rpn1

4

IPR016644

16,644

T-DNA border endonuclease virD2

VirD2

Family

47

false

This entry represents the rhizobacteria endonuclease, virD2. Tumour formation by A.tumefaciens involves the transfer and integration of a defined segment (T-DNA) of Ti plasmid DNA into the plant nuclear genome. The virD operon encodes a site-specific endonuclease that cleaves at a unique site within both 24 bp direct r...

[ "GO:0004520", "GO:0051819" ]

[ "DNA endonuclease activity", "symbiont-mediated induction of tumor or growth in host" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM", "PIRSF" ]

[ "NF010437", "PIRSF016095" ]

[ "PRK13863.1", "Endonuclease_VirD2" ]

[ 42, 42 ]

2

[]

0

[]

0

[ "PUB00075297" ]

[ "3021341" ]

[ "The virD operon of Agrobacterium tumefaciens encodes a site-specific endonuclease." ]

[ 1986 ]

1

[]

0

null

[ "Rhizobium/Agrobacterium group" ]

[ 47 ]

1

[]

0

true

Family

T-DNA border endonuclease virD2

VirD2

8

IPR016645

16,645

Uncharacterised conserved protein UCP016134

UCP016134

Family

564

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function A related protein ( ) from Methanopyrus kandleri has this domain fused to the ProFAR isomerase ( ) domain.

[]

0

[ "PIRSF" ]

[ "PIRSF016134" ]

[ "UCP016134" ]

[ 564 ]

1

[]

0

[ "1s04", "1xne", "2z0t" ]

3

[]

0

[]

0

null

[ "Archaea", "Bacteria", "Viruses", "metagenomes" ]

[ 91, 467, 2, 4 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP016134

UCP016134

2

IPR016646

16,646

Alpha-(1, 3)-fucosyltransferase/alpha-(1, 4)-fucosyltransferase, Helicobacter

Alpha-1_3/4-FUT_helico

Family

125

false

Helicobacter pylori is a prevalent bacterial, gastroduodenal pathogen of humans that can express Lewis (Le) and related antigens in the O-chains of its surface lipopolysaccharide. The alpha1,3-fucosyltransferase VI (FUT VI) protein is a key enzyme for synthesis of sialyl Lewis X and Lewis X in epithelial cells [ ]. Des...

[]

0

[ "PIRSF" ]

[ "PIRSF016150" ]

[ "Alpha1_3/4FUT_helico" ]

[ 125 ]

1

[]

0

[ "2nzw", "2nzx", "2nzy", "5zoi" ]

4

[ "PUB00043799", "PUB00043800", "PUB00043801", "PUB00043802" ]

[ "18274891", "18279843", "18607721", "18491404" ]

[ "Transcriptional regulation of the fucosyltransferase VI gene in hepatocellular carcinoma cells.", "Relevance of fucosylation and Lewis antigen expression in the bacterial gastroduodenal pathogen Helicobacter pylori.", "Core saccharide dependence of sialyl Lewis X biosynthesis.", "Expression and enzyme activi...

[ 2008, 2008, 2008, 2008 ]

4

[ "IPR001503" ]

[]

1

0

1

[ "Helicobacter" ]

[ 125 ]

1

[]

0

true

Family

Alpha-(1, 3)-fucosyltransferase/alpha-(1, 4)-fucosyltransferase, Helicobacter

Alpha-1_3/4-FUT_helico

4

IPR016647

16,647

Probable ribonuclease VapC, Thermococci

VapV_Thermo

Family

18

false

This entry represents a family of nucleic acid-binding proteins with PIN domain from Thermococci [ ]. It appears to be related to the VapC family of proteins.

[]

0

[ "PIRSF" ]

[ "PIRSF016154" ]

[ "NA-bd_PIN_PH0500" ]

[ 18 ]

1

[]

0

[ "1v96", "1y82", "1ye5", "5h4g", "5h4h" ]

5

[ "PUB00037924" ]

[ "16511069" ]

[ "Structure of PIN-domain protein PH0500 from Pyrococcus horikoshii." ]

[ 2005 ]

1

[ "IPR022907" ]

[]

1

0

1

[ "Thermococcaceae" ]

[ 18 ]

1

[]

0

true

Family

Probable ribonuclease VapC, Thermococci

VapV_Thermo

8

IPR016648

16,648

Uncharacterised conserved protein UCP016175, prenyltransferase beta-subunit-related

UCP016175_prenyltrans-rel

Family

68

false

There is currently no experimental data for members of this group. However, they are distantly related to the beta subunits of protein prenyltransferases--protein farnesyltransferase (FTase) and protein geranylgeranyl transferase type II (GGTase-II). Protein prenyltransferases catalyse the posttranslational modificatio...

[]

0

[ "PIRSF" ]

[ "PIRSF016175" ]

[ "UCP016175" ]

[ 68 ]

1

[]

0

[]

0

[ "PUB00025021", "PUB00027784" ]

[ "9657673", "9230058" ]

[ "Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate.", "Yeast protein farnesyltransferase. Site-directed mutagenesis of conserved residues in the beta-subunit." ]

[ 1998, 1997 ]

2

[]

0

null

[ "Archaea" ]

[ 68 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP016175, prenyltransferase beta-subunit-related

UCP016175_prenyltrans-rel

2

IPR016649

16,649

Glial cell line-derived neurotrophic factor

GDNF

Family

187

false

This group represents glial cell line-derived neurotrophic factor (GDNF). This is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake [ , ]. Defects in GDNF are a cause of congenital central hypoventilation syndrome (al...

[]

0

[ "PIRSF" ]

[ "PIRSF016238" ]

[ "GDNF" ]

[ 187 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-419037", "R-HSA-5673001", "R-HSA-8853659", "R-HSA-9830674", "R-MMU-5673001", "R-MMU-8853659", "R-RNO-5673001", "R-RNO-8853659" ]

[ "REACTOME:R-HSA-419037", "REACTOME:R-HSA-5673001", "REACTOME:R-HSA-8853659", "REACTOME:R-HSA-9830674", "REACTOME:R-MMU-5673001", "REACTOME:R-MMU-8853659", "REACTOME:R-RNO-5673001", "REACTOME:R-RNO-8853659" ]

8

[]

0

[ "PUB00042870", "PUB00042871", "PUB00042872", "PUB00042873" ]

[ "8493557", "8988018", "9497256", "9359036" ]

[ "GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.", "Glial cell line-derived neurotrophic factor: selective reduction of the intermolecular disulfide linkage and characterization of its disulfide structure.", "Mutations of the RET-GDNF signaling pathway in Ondine's curse.",...

[ 1993, 1996, 1998, 1997 ]

4

[ "IPR043401" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 187 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 1, 8 ]

4

true

Family

Glial cell line-derived neurotrophic factor

GDNF

8

IPR016651

16,651

Leucine carboxyl methyltransferase 1

LCMT1

Family

4,967

false

This group represents the Ppm1 (also known as LCMT1) subgroup of leucine carboxymethyltransferases. Ppm1 regulates the activity of serine/threonine phosphatase 2A (PP2A) through methylation of the C-terminal leucine residue of the catalytic subunit of PP2A [ , , ]. This affects the heteromultimeric composition of PP2A ...

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF016305", "PTHR13600" ]

[ "LCM_mtfrase", "" ]

[ 4073, 4925 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.1.1.233", "R-BTA-69273", "R-CEL-69273", "R-HSA-69273", "R-RNO-69273", "R-SCE-69273", "R-SPO-69273" ]

[ "EC:2.1.1.233", "REACTOME:R-BTA-69273", "REACTOME:R-CEL-69273", "REACTOME:R-HSA-69273", "REACTOME:R-RNO-69273", "REACTOME:R-SCE-69273", "REACTOME:R-SPO-69273" ]

7

[ "1rjd", "1rje", "1rjf", "1rjg", "2ob1", "2ob2", "3iei", "3o7w", "3p71" ]

9

[ "PUB00030688", "PUB00034741", "PUB00034742", "PUB00034743" ]

[ "14660564", "10600115", "11697862", "11060018" ]

[ "Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity.", "Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.", "Protein phosphatase ...

[ 2004, 1999, 2001, 2000 ]

4

[ "IPR007213" ]

[]

1

0

1

[ "Chitinophaga", "Eukaryota" ]

[ 2, 4965 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 2, 2, 6, 6, 1, 2, 5, 1, 1, 10 ]

12

true

Family

Leucine carboxyl methyltransferase 1

LCMT1

2

IPR016652

16,652

Ubiquitinyl hydrolase

Ubiquitinyl_hydrolase

Family

5,429

false

This entry includes a group of ubiquitinyl hydrolases, also known as ubiquitin carboxyl-terminal hydrolases, including USP13 and USP5 from animals, and Ubp14 from plants and fungi.

[ "GO:0004843", "GO:0016579" ]

[ "cysteine-type deubiquitinase activity", "protein deubiquitination" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF016308" ]

[ "UBP" ]

[ 5429 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.19.12", "R-BTA-5689880", "R-BTA-8948751", "R-DDI-5689880", "R-DDI-8866652", "R-DDI-8948751", "R-DRE-5689880", "R-DRE-8948751", "R-HSA-5689880", "R-HSA-8866652", "R-HSA-8948751", "R-MMU-5689880", "R-MMU-8866652", "R-MMU-8948751", "R-SPO-5689880", "R-SPO-8948751" ]

[ "EC:3.4.19.12", "REACTOME:R-BTA-5689880", "REACTOME:R-BTA-8948751", "REACTOME:R-DDI-5689880", "REACTOME:R-DDI-8866652", "REACTOME:R-DDI-8948751", "REACTOME:R-DRE-5689880", "REACTOME:R-DRE-8948751", "REACTOME:R-HSA-5689880", "REACTOME:R-HSA-8866652", "REACTOME:R-HSA-8948751", "REACTOME:R-MMU-56...

16

[ "3ihp" ]

1

[ "PUB00033377", "PUB00058309", "PUB00078045", "PUB00078046" ]

[ "12686616", "22216260", "9305625", "19098288" ]

[ "Catabolite degradation of fructose-1,6-bisphosphatase in the yeast Saccharomyces cerevisiae: a genome-wide screen identifies eight novel GID genes and indicates the existence of two degradation pathways.", "Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-l...

[ 2003, 2011, 1997, 2009 ]

4

[]

0

null

[ "Eukaryota" ]

[ 5429 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 2, 11, 1, 6, 4, 1, 2, 9, 1, 1, 5 ]

12

true

Family

Ubiquitinyl hydrolase

Ubiquitinyl_hydrolase

8

IPR016653

16,653

tRNA (guanine(9)-N(1))-methyltransferase TRM10/TRM10A

TRM10/TRM10A

Family

1,143

false

Yeast tRNA (guanine(9)-N1)-methyltransferase TRM10 catalyses the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNAs [ , ]. This group also includes metazoa homologue A (TRM10A). In humans there are three TRM10 orthologues; a nonsense mutation in TRMT10A has been associated with microcephaly [ ].

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF016323" ]

[ "tRNA_m1G_mtfrase_met" ]

[ 1143 ]

1

[ "EC", "REACTOME" ]

[ "2.1.1.221", "R-HSA-6782315" ]

[ "EC:2.1.1.221", "REACTOME:R-HSA-6782315" ]

2

[ "4jwh" ]

1

[ "PUB00058128", "PUB00058129", "PUB00088046" ]

[ "12702816", "15640439", "25053765" ]

[ "Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9.", "Detection and discovery of RNA modifications using microarrays.", "TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly." ]

[ 2003, 2005, 2014 ]

3

[ "IPR007356" ]

[]

1

0

1

[ "Eukaryota" ]

[ 1143 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 2, 2, 1, 2, 3, 5, 1, 1 ]

9

true

Family

tRNA (guanine(9)-N(1))-methyltransferase TRM10/TRM10A

TRM10/TRM10A

9

IPR016654

16,654

U6 snRNA-associated Sm-like protein LSm2

U6_snRNA_Lsm2

Family

3,653

false

This group represents an U6 snRNA-associated Sm-like protein LSm2. It is a component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. LSm2 binds specifically to the 3'-terminal U-tract of U6 snRNA [ ].

[ "GO:0006397" ]

[ "mRNA processing" ]

[ "biological_process" ]

1

[ "PIRSF", "PANTHER", "CDD" ]

[ "PIRSF016394", "PTHR13829", "cd01725" ]

[ "U6_snRNA_Lsm2", "", "LSm2" ]

[ 2567, 3471, 3458 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-430039", "R-HSA-430039", "R-HSA-72163", "R-MMU-430039", "R-MMU-72163", "R-SCE-430039", "R-SPO-430039" ]

[ "REACTOME:R-DDI-430039", "REACTOME:R-HSA-430039", "REACTOME:R-HSA-72163", "REACTOME:R-MMU-430039", "REACTOME:R-MMU-72163", "REACTOME:R-SCE-430039", "REACTOME:R-SPO-430039" ]

7

[ "3jcm", "3jcr", "4c8q", "4c92", "4m75", "4m77", "4m78", "4m7a", "4m7d", "4n0a", "5gan", "5nrl", "5o9z", "5vsu", "5zwm", "5zwo", "6ah0", "6ahd", "6aso", "6ppn", "6ppp", "6ppq", "6ppv", "6qw6", "6qx9", "7abg", "8h6e", "8h6j", "8h6k", "8h6l", "8qo9", "8qxd"...

38

[ "PUB00059220" ]

[ "10523320" ]

[ "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro." ]

[ 1999 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 3652, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 2, 1, 1, 1, 5, 2, 3, 7, 1, 1, 7 ]

12

true

Family

U6 snRNA-associated Sm-like protein LSm2

U6_snRNA_Lsm2

2

IPR016655

16,655

Prefoldin subunit 3

PFD3

Family

4,680

false

Prefoldin subunit 3 (PFD3, also known as VBP-1) is part of the heteromeric co-chaperone complex, which delivers unfolded proteins to cytosolic chaperonin and acts as a cofactor. PFD3 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. It binds to nascent polypeptide chain and promote...

[ "GO:0006457", "GO:0016272" ]

[ "protein folding", "prefoldin complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF016396", "PTHR12409" ]

[ "Prefoldin_subunit_3", "" ]

[ 3906, 4680 ]

2

[ "REACTOME" ]

[ "R-HSA-389957" ]

[ "REACTOME:R-HSA-389957" ]

1

[ "6nr8", "6nr9", "6nrb", "6nrc", "6nrd", "7wu7" ]

6

[ "PUB00008051", "PUB00071716" ]

[ "9630229", "22451918" ]

[ "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.", "Drosophila Mgr, a Prefoldin subunit cooperating with von Hippel Lindau to regulate tubulin stability." ]

[ 1998, 2012 ]

2

[ "IPR004127" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4680 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 1, 2, 2, 3, 2, 2, 2, 1, 1, 13 ]

12

true

Family

Prefoldin subunit 3

PFD3

3

IPR016656

16,656

Transcription initiation factor TFIIE, beta subunit

TFIIE-bsu

Family

5,375

false

Initiation of eukaryotic mRNA transcription requires melting of promoter DNA with the help of the general transcription factors TFIIE and TFIIH. In higher eukaryotes, the general transcription factor TFIIE consists of two subunits: the large alpha subunit ( ) and the small beta ( ). TFIIE beta has been found to bind to...

[ "GO:0006367", "GO:0005673" ]

[ "transcription initiation at RNA polymerase II promoter", "transcription factor TFIIE complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF016398", "PTHR12716" ]

[ "TFIIE-beta", "" ]

[ 3133, 5370 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-DDI-674695", "R-DDI-6807505", "R-DDI-73776", "R-DDI-73779", "R-DDI-75953", "R-DDI-76042", "R-HSA-167161", "R-HSA-167162", "R-HSA-167172", "R-HSA-674695", "R-HSA-6807505", "R-HSA-73776", "R-HSA-73779", "R-HSA-75953", "R-HSA-76042", "R-MMU-674695", "R-MMU-6807505", "R-MMU-73776", ...

[ "REACTOME:R-DDI-674695", "REACTOME:R-DDI-6807505", "REACTOME:R-DDI-73776", "REACTOME:R-DDI-73779", "REACTOME:R-DDI-75953", "REACTOME:R-DDI-76042", "REACTOME:R-HSA-167161", "REACTOME:R-HSA-167162", "REACTOME:R-HSA-167172", "REACTOME:R-HSA-674695", "REACTOME:R-HSA-6807505", "REACTOME:R-HSA-73776...

33

[ "1d8j", "1d8k", "5fmf", "5fyw", "5fz5", "5gpy", "5iy6", "5iy7", "5iy8", "5iy9", "5iya", "5iyb", "5iyc", "5iyd", "5oqj", "5oqm", "5sva", "6gyl", "6gym", "6o9l", "7eg9", "7ega", "7egb", "7egc", "7ena", "7enc", "7lbm", "7ml0", "7ml1", "7ml2", "7ml4", "7nvr"...

70

[ "PUB00006521" ]

[ "10716934" ]

[ "Structure of the central core domain of TFIIEbeta with a novel double-stranded DNA-binding surface." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota" ]

[ 5375 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 2, 3, 4, 1, 7, 4, 1, 1, 8 ]

12

true

Family

Transcription initiation factor TFIIE, beta subunit

TFIIE-bsu

1

IPR016657

16,657

Phosphoacetylglucosamine mutase

PAGM

Family

4,336

false

This group represents a phosphoacetylglucosamine mutase (PAGM; also known as phosphoglucomutase 3 or N-acetylglucosamine-phosphate mutase [ ]). It is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into GlcNAc-1-phosphate as part of the UDP-N-acetylglucosamine (UDP...

[ "GO:0004610" ]

[ "phosphoacetylglucosamine mutase activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "CDD" ]

[ "PIRSF016408", "cd03086" ]

[ "PAGM", "PGM3" ]

[ 4053, 4307 ]

2

[ "EC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.4.2.3", "PWY-5514", "PWY-6906", "R-HSA-446210", "R-MMU-446210", "R-SCE-446210", "R-SPO-446210", "R-SSC-446210" ]

[ "EC:5.4.2.3", "METACYC:PWY-5514", "METACYC:PWY-6906", "REACTOME:R-HSA-446210", "REACTOME:R-MMU-446210", "REACTOME:R-SCE-446210", "REACTOME:R-SPO-446210", "REACTOME:R-SSC-446210" ]

8

[ "2dka", "2dkc", "2dkd", "4bju", "5o9x", "5oaw" ]

6

[ "PUB00040263", "PUB00042563", "PUB00080841", "PUB00080845" ]

[ "16651269", "11004509", "12174217", "17548465" ]

[ "Crystal structures of N-acetylglucosamine-phosphate mutase, a member of the alpha-D-phosphohexomutase superfamily, and its substrate and product complexes.", "Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for ...

[ 2006, 2000, 2002, 2007 ]

4

[]

0

null

[ "Eukaryota" ]

[ 4336 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 1, 13, 7, 1, 1, 7, 1, 2, 4 ]

12

true

Family

Phosphoacetylglucosamine mutase

PAGM

4

IPR016658

16,658

DNA primase LEF1

DNA_primase_LEF1

Family

154

false

Baculovirus late expression factor 1 (LEF-1) has been shown to have primase activity [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF016433" ]

[ "Viral_DNA_prim" ]

[ 154 ]

1

[]

0

[]

0

[ "PUB00010485" ]

[ "11836407" ]

[ "Baculovirus replication factor LEF-1 is a DNA primase." ]

[ 2002 ]

1

[]

0

null

[ "Baculoviridae" ]

[ 154 ]

1

[]

0

true

Family

DNA primase LEF1

DNA_primase_LEF1

9

IPR016659

16,659

Transcription factor II-I

TF_II-I

Family

1,386

false

This group represents a general transcription factor II-I. TFII-I associates with multiple proteins to modulate both basal and signal-induced transcription [ , ]. TFII-I transcription factors play an essential role during early vertebrate embryogenesis [ ].

[ "GO:0006366" ]

[ "transcription by RNA polymerase II" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF016441" ]

[ "TF_II-I" ]

[ 1386 ]

1

[]

0

[]

0

[ "PUB00060844", "PUB00060845", "PUB00060846" ]

[ "12082086", "22037610", "22628223" ]

[ "cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I.", "Biochemistry and biology of the inducible multifunctional transcription factor TFII-I: 10 years later.", "Epigenetic modulation by TFII-I during embryonic stem cell differentiation." ]

[ 2002, 2012, 2012 ]

3

[]

0

null

[ "Tetrapoda" ]

[ 1386 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 14, 9, 29 ]

3

true

Family

Transcription factor II-I

TF_II-I

3

IPR016660

16,660

Kinase associated protein phosphatase

Kinase_assoc_Pase

Family

79

false

This entry represents a group of kinase associated protein phosphatases from plants, including KAPP (also known as protein phosphatase 2C 70) from Arabidopsis. KAPP dephosphorylates the Ser/Thr receptor-like kinase RLK5 [ ]. It is a component of a signaling pathway which mediates adaptation to NaCl stress [ ].

[ "GO:0004721" ]

[ "phosphoprotein phosphatase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF016465" ]

[ "Kap_phosphatase" ]

[ 79 ]

1

[]

0

[]

0

[ "PUB00073656", "PUB00109979" ]

[ "15592873", "18162596" ]

[ "The Arabidopsis SERK1 protein interacts with the AAA-ATPase AtCDC48, the 14-3-3 protein GF14lambda and the PP2C phosphatase KAPP.", "The Arabidopsis kinase-associated protein phosphatase regulates adaptation to Na+ stress." ]

[ 2005, 2008 ]

2

[ "IPR015655" ]

[]

1

0

1

[ "Mesangiospermae" ]

[ 79 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 5, 5 ]

3

true

Family

Kinase associated protein phosphatase

Kinase_assoc_Pase

1

IPR016661

16,661

Prefoldin, subunit 4

PFDN4

Family

4,306

false

This group represents a prefoldin, subunit 4 (PFDN4, also known as Gim3 in budding yeasts). PFDN4 is part of the prefoldin heterohexamer copmlex (consists of two PFD-alpha type and four PFD-beta type subunits) that binds specifically to cytosolic chaperonin (c-CPN) and transfers targeted proteins to it. It binds to nas...

[ "GO:0006457", "GO:0016272" ]

[ "protein folding", "prefoldin complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF016477", "PTHR21100" ]

[ "Prefoldin_subunit_4", "" ]

[ 3612, 4306 ]

2

[ "REACTOME" ]

[ "R-HSA-389957" ]

[ "REACTOME:R-HSA-389957" ]

1

[ "6nr8", "6nr9", "6nrb", "6nrc", "6nrd", "7wu7" ]

6

[ "PUB00008051", "PUB00063296" ]

[ "9630229", "17936702" ]

[ "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin.", "S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling." ]

[ 1998, 2007 ]

2

[ "IPR002777" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4306 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 4, 3, 5, 1, 2, 3, 1, 1, 9 ]

12

true

Family

Prefoldin, subunit 4

PFDN4

8

IPR016662

16,662

Acyl-CoA thioesterase, long chain

Acyl-CoA_thioEstase_long-chain

Family

5,784

false

Acyl-CoA thioesterases are a group of enzymes that catalyse the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH). They consequently have the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. They may also be involved in the metabolic regulation of peroxisome proli...

[ "GO:0016790", "GO:0006637" ]

[ "thiolester hydrolase activity", "acyl-CoA metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF016521" ]

[ "Acyl-CoA_hydro" ]

[ 5784 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.1.2", "3.1.2.2", "PWY-1121", "PWY-321", "PWY-5972", "PWY-5996", "PWY-6733", "PWY-7723", "R-HSA-159418", "R-HSA-193368", "R-HSA-390247", "R-HSA-77289", "R-HSA-9033241", "R-HSA-9837999", "R-MMU-159418", "R-MMU-193368", "R-MMU-390247", "R-MMU-77289", "R-MMU-9033241", "R-MMU-983...

[ "EC:3.1.2", "EC:3.1.2.2", "METACYC:PWY-1121", "METACYC:PWY-321", "METACYC:PWY-5972", "METACYC:PWY-5996", "METACYC:PWY-6733", "METACYC:PWY-7723", "REACTOME:R-HSA-159418", "REACTOME:R-HSA-193368", "REACTOME:R-HSA-390247", "REACTOME:R-HSA-77289", "REACTOME:R-HSA-9033241", "REACTOME:R-HSA-9837...

25

[ "3hlk", "3k2i" ]

2

[ "PUB00015864", "PUB00043443", "PUB00043444" ]

[ "10876240", "18247525", "18338382" ]

[ "Crystal structure of the Escherichia coli thioesterase II, a homolog of the human Nef binding enzyme.", "Divergence of function in the hot dog fold enzyme superfamily: the bacterial thioesterase YciA.", "Structural and enzymatic characterization of HP0496, a YbgC thioesterase from Helicobacter pylori." ]

[ 2000, 2008, 2008 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "metagenomes" ]

[ 1123, 4581, 71, 9 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 5, 34, 11, 16, 21 ]

5

true

Family

Acyl-CoA thioesterase, long chain

Acyl-CoA_thioEstase_long-chain

8

IPR016663

16,663

Myelin-oligodendrocyte glycoprotein

Myelin-oligodendrocyte_glycop

Family

402

false

This group represents a myelin-oligodendrocyte glycoprotein.

[]

0

[ "PIRSF" ]

[ "PIRSF016522" ]

[ "MOG" ]

[ 402 ]

1

[]

0

[]

0

[]

0

[ "IPR050504" ]

[]

1

0

1

[ "Mammalia" ]

[ 402 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 10, 5, 6 ]

3

true

Family

Myelin-oligodendrocyte glycoprotein

Myelin-oligodendrocyte_glycop

1

IPR016665

16,665

SAS complex subunit SAS5/transcription initiation factor TFIID subunit 14

Sas5/TAF14

Family

1,121

false

This entry represents the Sas5 (Something About Silencing 5) subunit from the SAS complex, as well as subunit 14 (TAF14) from transcription initiation factor IID. The native yeast SAS complex is a trimeric acetyltransferase complex composed of Sas2, Sas4, and Sas5. Sas2 is a member of the MYST protein family of histone...

[]

0

[ "PIRSF" ]

[ "PIRSF016551" ]

[ "SAS5/TFIID_14" ]

[ 1121 ]

1

[ "GP" ]

[ "GenProp2054" ]

[ "GP:GenProp2054" ]

1

[ "5sva" ]

1

[ "PUB00042744" ]

[ "15659401" ]

[ "Characterization of the yeast trimeric-SAS acetyltransferase complex." ]

[ 2005 ]

1

[ "IPR005033" ]

[]

1

0

1

[ "Opisthokonta" ]

[ 1121 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 1 ]

3

true

Family

SAS complex subunit SAS5/transcription initiation factor TFIID subunit 14

Sas5/TAF14

9

IPR016666

16,666

TGF beta-induced protein/periostin

TGFBI/POSTN

Family

2,503

false

This entry includes TGF beta-induced protein (TGFBI, also known as betaig-H3 and keratoepithelin) and Periostin. They are are paralogues that contain a single emilin (EMI) and four fasciclin-1 (FAS1) modules and are secreted from cells [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF016553" ]

[ "BIGH3_OSF2" ]

[ 2503 ]

1

[ "REACTOME" ]

[ "R-HSA-977225" ]

[ "REACTOME:R-HSA-977225" ]

1

[ "5nv6", "5yjg", "5yjh" ]

3

[ "PUB00077081", "PUB00077083", "PUB00077084" ]

[ "22949874", "18381746", "26288337" ]

[ "Transforming growth Factor-Beta-Induced Protein (TGFBI)/(βig-H3): a matrix protein with dual functions in ovarian cancer.", "Periostin, secreted from stromal cells, has biphasic effect on cell migration and correlates with the epithelial to mesenchymal transition of human pancreatic cancer cells.", "Periostin ...

[ 2012, 2008, 2015 ]

3

[]

0

null

[ "Gnathostomata" ]

[ 2503 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 12, 5, 10, 11 ]

4

true

Family

TGF beta-induced protein/periostin

TGFBI/POSTN

1

IPR016667

16,667

Capsular polysaccharide synthesis, CpsB/CapC

Caps_polysacc_synth_CpsB/CapC

Family

7,587

false

Capsular polysaccharide biosynthesis proteins are critical for the production of a mature capsule in vitro. Members of Streptococcus pneumoniae have variable capsules, with about 90 known capsular serotypes that all have their own polysaccharide structure. cps14B to cps14H products are similar to other proteins involve...

[ "GO:0004725", "GO:0030145" ]

[ "protein tyrosine phosphatase activity", "manganese ion binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF19567", "PIRSF016557", "PTHR39181" ]

[ "CpsB_CapC", "Caps_synth_CpsB", "" ]

[ 7583, 6533, 7548 ]

3

[ "EC" ]

[ "3.1.3.48" ]

[ "EC:3.1.3.48" ]

1

[ "2wjd", "2wje", "2wjf", "3qy6", "3qy7", "3qy8" ]

6

[ "PUB00044087", "PUB00044088", "PUB00044089", "PUB00044090" ]

[ "9235953", "11751838", "16415593", "11606571" ]

[ "Functional analysis of glycosyltransferases encoded by the capsular polysaccharide biosynthesis locus of Streptococcus pneumoniae serotype 14.", "Streptococcus pneumoniae capsule biosynthesis protein CpsB is a novel manganese-dependent phosphotyrosine-protein phosphatase.", "Role of protein phosphorylation on ...

[ 1997, 2002, 2005, 2001 ]

4

[]

[ "IPR048208" ]

0

1

0

[ "Bacteria", "Eukaryota", "Inoviridae sp. ctDEu7", "metagenomes" ]

[ 7471, 6, 1, 109 ]

4

[]

0

true

Family

Capsular polysaccharide synthesis, CpsB/CapC

Caps_polysacc_synth_CpsB/CapC

7

IPR016668

16,668

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

NDUFS6

Family

595

false

NDUFS6 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis [ ]. It harbours a Zn-binding site and is essential for biogenesis of mitochondrial complex I [ ].

[ "GO:0006120" ]

[ "mitochondrial electron transport, NADH to ubiquinone" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF016564" ]

[ "CI-13KD-A" ]

[ 595 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-611105", "R-BTA-6799198", "R-HSA-611105", "R-HSA-6799198", "R-MMU-611105", "R-MMU-6799198", "R-RNO-611105", "R-RNO-6799198" ]

[ "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198", "REACTOME:R-RNO-611105", "REACTOME:R-RNO-6799198" ]

8

[ "5gpn", "5gup", "5lnk", "5o31", "5xtb", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6q9d", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6zk9", "6zkc", "6zkd", "6zke", "6zkf", "6zkg", "6zkh", "6zki", "6zkj"...

230

[ "PUB00084978", "PUB00084979" ]

[ "15372108", "25902503" ]

[ "NDUFS6 mutations are a novel cause of lethal neonatal mitochondrial complex I deficiency.", "Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I." ]

[ 2004, 2015 ]

2

[]

0

null

[ "Eukaryota" ]

[ 595 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]

[ 2, 1, 1, 1, 2, 2, 2, 5 ]

8

true

Family

NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

NDUFS6

2

IPR016669

16,669

Interferon alpha/beta receptor 1

Interferon_alpha/beta_rcpt-1

Family

129

false

The interferon-alpha/beta receptor 1 family of proteins associates with IFNAR2 to form the type I interferon receptor. Binding of interferons alpha and beta to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.

[ "GO:0004904", "GO:0019221" ]

[ "interferon receptor activity", "cytokine-mediated signaling pathway" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF016567" ]

[ "IFN_alpha/beta_recept-1" ]

[ 129 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-909733", "R-BTA-912694", "R-HSA-909733", "R-HSA-912694", "R-HSA-9679191", "R-HSA-9705671", "R-HSA-9833109", "R-MMU-909733", "R-MMU-912694" ]

[ "REACTOME:R-BTA-909733", "REACTOME:R-BTA-912694", "REACTOME:R-HSA-909733", "REACTOME:R-HSA-912694", "REACTOME:R-HSA-9679191", "REACTOME:R-HSA-9705671", "REACTOME:R-HSA-9833109", "REACTOME:R-MMU-909733", "REACTOME:R-MMU-912694" ]

9

[]

0

[]

0

[]

0

null

[ "Amniota" ]

[ 129 ]

1

[ "Homo sapiens", "Mus musculus" ]

[ 2, 3 ]

2

true

Family

Interferon alpha/beta receptor 1

Interferon_alpha/beta_rcpt-1

6

IPR016670

16,670

DNA damage-inducible transcript 3

DNA_damage_induc_transcript_3

Family

683

false

This group represents the DNA damage-inducible transcript 3 protein, a C/EBP-homologous protein also known as C/EBP-zeta.

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF016571", "PTHR16833" ]

[ "C/EBPzeta_CHOP_DDIT3", "" ]

[ 187, 683 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-380994", "R-HSA-381183", "R-HSA-9614657", "R-HSA-9633012", "R-HSA-9648895" ]

[ "REACTOME:R-HSA-380994", "REACTOME:R-HSA-381183", "REACTOME:R-HSA-9614657", "REACTOME:R-HSA-9633012", "REACTOME:R-HSA-9648895" ]

5

[]

0

[]

0

[]

0

null

[ "Gnathostomata" ]

[ 683 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 3, 3, 4 ]

4

true

Family

DNA damage-inducible transcript 3

DNA_damage_induc_transcript_3

7

IPR016672

16,672

Polyketide biosynthesis protein CurC, predicted

Polyketide_Synth_CurC_prd

Family

1,172

false

This group represents a predicted polyketide biosynthesis protein CurC and related proteins that are members of cupin superfamily.

[]

0

[ "PIRSF" ]

[ "PIRSF016602" ]

[ "CurC_prd" ]

[ 1172 ]

1

[]

0

[ "4mv2", "4q29" ]

2

[]

0

[]

0

null

[ "Bacteria", "Halobacteriales" ]

[ 1151, 21 ]

2

[]

0

true

Family

Polyketide biosynthesis protein CurC, predicted

Polyketide_Synth_CurC_prd

8

IPR016673

16,673

Histamine N-methyltransferase-like

HHMT-like

Family

1,382

false

This group represents histamine N-methyltransferase, which inactivates histamine by N-methylation. It plays an important role in degrading histamine and in regulating the airway response to histamine [ ]. This entry also includes chicken carnosine N-methyltransferase, which may be a paralogue of histamine N-methyltrans...

[ "GO:0008170" ]

[ "N-methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "PROFILE" ]

[ "PIRSF016616", "PS51597" ]

[ "HHMT", "SAM_HNMT" ]

[ 1106, 1366 ]

2

[ "EC", "METACYC", "REACTOME", "REACTOME" ]

[ "2.1.1.8", "PWY-6181", "R-HSA-2408508", "R-HSA-70921" ]

[ "EC:2.1.1.8", "METACYC:PWY-6181", "REACTOME:R-HSA-2408508", "REACTOME:R-HSA-70921" ]

4

[ "1jqd", "1jqe", "2aot", "2aou", "2aov", "2aow", "2aox" ]

7

[ "PUB00006319", "PUB00054125", "PUB00057957", "PUB00057958", "PUB00058031", "PUB00075696" ]

[ "7897657", "12826405", "16225687", "21858014", "7943261", "23705015" ]

[ "Universal catalytic domain structure of AdoMet-dependent methyltransferases.", "Many paths to methyltransfer: a chronicle of convergence.", "Natural history of S-adenosylmethionine-binding proteins.", "Comprehensive structural and substrate specificity classification of the Saccharomyces cerevisiae methyltra...

[ 1995, 2003, 2005, 2011, 1994, 2013 ]

6

[]

0

null

[ "Eumetazoa", "Trichodesmium erythraeum (strain IMS101)" ]

[ 1381, 1 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 3, 2, 3 ]

4

true

Family

Histamine N-methyltransferase-like

HHMT-like

3