LiteFold/InterPro · Datasets at Hugging Face

IPR016674

16,674

Phospholipase D-like

PLipase_D-like

Family

96

false

Phospholipase D displays sphingomyelinase and haemolytic activity. In Corynebacterium pseudotuberculosis and other pathogens, the enzyme acts as a virulence factor affecting bacterial dissemination and survival within the host [ , , ].

[ "GO:0004620", "GO:0016042" ]

[ "glycerophospholipase activity", "lipid catabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF016632" ]

[ "Phospholipase_actinobac/fun" ]

[ 96 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "3.1.4.-", "3.1.4.41", "PWY-5978", "PWY-6129", "PWY-6689", "PWY-7119", "PWY-7366" ]

[ "EC:3.1.4.-", "EC:3.1.4.41", "METACYC:PWY-5978", "METACYC:PWY-6129", "METACYC:PWY-6689", "METACYC:PWY-7119", "METACYC:PWY-7366" ]

7

[ "9yd8" ]

1

[ "PUB00073648", "PUB00073649", "PUB00073650" ]

[ "7934899", "7737503", "8406819" ]

[ "Targeted mutagenesis of the phospholipase D gene results in decreased virulence of Corynebacterium pseudotuberculosis.", "Toxic phospholipases D of Corynebacterium pseudotuberculosis, C. ulcerans and Arcanobacterium haemolyticum: cloning and sequence homology.", "Arcanobacterium haemolyticum phospholipase D is...

[ 1994, 1995, 1993 ]

3

[ "IPR060039" ]

[]

1

0

1

[ "Actinomycetes", "Dikarya" ]

[ 32, 64 ]

2

[]

0

true

Family

Phospholipase D-like

PLipase_D-like

6

IPR016675

16,675

Uncharacterised conserved protein UCP016666

UCP016666

Family

98

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09910", "PIRSF016666" ]

[ "DUF2139", "UCP016666" ]

[ 98, 40 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea" ]

[ 98 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP016666

UCP016666

9

IPR016676

16,676

Phospholipid/glycerol acyltransferase, predicted

P_lipid/glycerol_AcTrfase_prd

Family

2,900

false

This group represents a predicted phospholipid/glycerol acyltransferase from bacteria.

[]

0

[ "PIRSF" ]

[ "PIRSF016753" ]

[ "P_lipid/glycerol_ac_tran_prd" ]

[ 2900 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "freshwater metagenome" ]

[ 2884, 16 ]

2

[]

0

true

Family

Phospholipid/glycerol acyltransferase, predicted

P_lipid/glycerol_AcTrfase_prd

3

IPR016677

16,677

Uncharacterised conserved protein UCP016817, ATP-dependent carboligase

UCP016817_carboligase

Family

724

false

This group represents a predicted ATP-dependent carboligase related to biotin carboxylase.

[]

0

[ "PIRSF" ]

[ "PIRSF016817" ]

[ "UCP016817_carboligase" ]

[ 724 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanobacteriota", "ecological metagenomes" ]

[ 511, 207, 6 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP016817, ATP-dependent carboligase

UCP016817_carboligase

3

IPR016678

16,678

Mono-ADP-ribosyltransferase C3/Edin

Mono-ADP_RibTrfase_C3/Edin

Family

28

false

This group represents a group of mono-ADP-ribosyltransferases, including Edin (epidermal cell differentiation inhibitor) from Staphylococcus aureus and C3 from phage. Edin inhibits terminal differentiation of cultured mouse keratinocytes [ ]. C3 is an ADP-ribosyltransferase [ , ].

[ "GO:0016763", "GO:1990404" ]

[ "pentosyltransferase activity", "NAD+-protein mono-ADP-ribosyltransferase activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PIRSF" ]

[ "PIRSF016951" ]

[ "MADP_ribosyltransf_Edin" ]

[ 28 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.4.2.-", "PWY-5381", "PWY-5800", "PWY-6148", "PWY-6720", "PWY-7018", "PWY-7025", "PWY-7450", "PWY-7817", "PWY-7981" ]

[ "EC:2.4.2.-", "METACYC:PWY-5381", "METACYC:PWY-5800", "METACYC:PWY-6148", "METACYC:PWY-6720", "METACYC:PWY-7018", "METACYC:PWY-7025", "METACYC:PWY-7450", "METACYC:PWY-7817", "METACYC:PWY-7981" ]

10

[ "1g24", "1gze", "1gzf", "1ojq", "1ojz", "1r45", "1r4b", "1uzi", "2a78", "2a9k", "2bov", "2c89", "2c8a", "2c8b", "2c8c", "2c8d", "2c8e", "2c8f", "2c8g", "2c8h", "3bw8" ]

21

[ "PUB00032787", "PUB00075302", "PUB00075303" ]

[ "15809419", "2256941", "2108433" ]

[ "Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase.", "A novel epidermal cell differentiation inhibitor (EDIN): purification and characterization from Staphylococcus aureus.", "DNA sequence of exoenzyme C3, an ADP-ribosyltransferase encoded by Clostridium botulinum C...

[ 2005, 1990, 1990 ]

3

[]

0

null

[ "Bacillota", "unclassified Caudoviricetes" ]

[ 26, 2 ]

2

[]

0

true

Family

Mono-ADP-ribosyltransferase C3/Edin

Mono-ADP_RibTrfase_C3/Edin

4

IPR016679

16,679

Transcription factor, GATA, plant

TF_GATA_pln

Family

3,035

false

This group represents GATA transcription factors found in plants. They may be involved in the regulation of some light-responsive genes [ ].

[ "GO:0003677", "GO:0045893", "GO:0005634" ]

[ "DNA binding", "positive regulation of DNA-templated transcription", "nucleus" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF016992" ]

[ "TF_GATA_plant" ]

[ 3035 ]

1

[]

0

[]

0

[ "PUB00085139" ]

[ "12139008" ]

[ "Arabidopsis thaliana GATA factors: organisation, expression and DNA-binding characteristics." ]

[ 2002 ]

1

[]

0

null

[ "Embryophyta" ]

[ 3035 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 33, 4, 2 ]

3

true

Family

Transcription factor, GATA, plant

TF_GATA_pln

7

IPR016680

16,680

NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8

NDUFA8

Family

4,038

false

This group represents a NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8 [ ].

[ "GO:0006120" ]

[ "mitochondrial electron transport, NADH to ubiquinone" ]

[ "biological_process" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF017016", "PTHR13344" ]

[ "NDUA8", "" ]

[ 2287, 4038 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-611105", "R-BTA-6799198", "R-HSA-611105", "R-HSA-6799198", "R-MMU-611105", "R-MMU-6799198" ]

[ "REACTOME:R-BTA-611105", "REACTOME:R-BTA-6799198", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-6799198", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-6799198" ]

6

[ "5gpn", "5gup", "5lc5", "5ldw", "5ldx", "5lnk", "5o31", "5xtc", "5xtd", "5xth", "5xti", "6g2j", "6g72", "6gcs", "6q9b", "6qa9", "6qbx", "6qc2", "6qc3", "6qc4", "6qc5", "6qc6", "6qc7", "6qc8", "6qc9", "6qca", "6qcf", "6rfq", "6rfr", "6rfs", "6x89", "6y79"...

267

[ "PUB00011388" ]

[ "9860297" ]

[ "The nuclear-encoded human NADH:ubiquinone oxidoreductase NDUFA8 subunit: cDNA cloning, chromosomal localization, tissue distribution, and mutation detection in complex-I-deficient patients." ]

[ 1998 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4038 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 6, 1, 2, 3, 2, 2, 1, 2, 5, 7 ]

10

true

Family

NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 8

NDUFA8

6

IPR016681

16,681

Succinylglutamate desuccinylase

SuccinylGlu_desuccinylase

Family

4,311

false

This entry describes succinylglutamate desuccinylase (ASTE, also known as N-succinyl-L-glutamate amidohydrolase, N2-succinylglutamate desuccinylase, and SGDS; EC 3.5.1.96) that catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. It hydrolyzes N-succinyl-L-glutamate to s...

[ "GO:0008270", "GO:0009017", "GO:0019544", "GO:0019545" ]

[ "zinc ion binding", "succinylglutamate desuccinylase activity", "L-arginine catabolic process to L-glutamate", "L-arginine catabolic process to succinate" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "HAMAP", "NCBIFAM", "PIRSF", "NCBIFAM", "CDD" ]

[ "MF_00767", "NF003706", "PIRSF017020", "TIGR03242", "cd03855" ]

[ "Arg_catab_AstE", "PRK05324.1", "AstE", "arg_catab_astE", "M14_ASTE" ]

[ 4196, 4310, 3295, 3544, 3863 ]

5

[ "EC", "GP", "GP" ]

[ "3.5.1.96", "GenProp0309", "GenProp1280" ]

[ "EC:3.5.1.96", "GP:GenProp0309", "GP:GenProp1280" ]

3

[ "1yw4", "1yw6", "2bco", "2g9d" ]

4

[ "PUB00043513" ]

[ "18293939" ]

[ "Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue." ]

[ 2008 ]

1

[ "IPR050178" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4302, 5, 4 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Succinylglutamate desuccinylase

SuccinylGlu_desuccinylase

3

IPR016682

16,682

Flagella accessory protein D, predicted, archaeal

FlaD_prd_arc

Family

156

false

This group represents a predicted flagella accessory protein D, archaeal type.

[]

0

[ "PIRSF" ]

[ "PIRSF017066" ]

[ "FlaD_arch_prd" ]

[ 156 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriati", "candidate division WOR-3 bacterium", "mine drainage metagenome" ]

[ 154, 1, 1 ]

3

[]

0

true

Family

Flagella accessory protein D, predicted, archaeal

FlaD_prd_arc

3

IPR016683

16,683

Glycosyl transferase, family 28, RedA, predicted

Glyco_trans_28_RedA_prd

Family

689

false

The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferas...

[]

0

[ "PIRSF" ]

[ "PIRSF017085" ]

[ "Glycosyltransf_RedA_prd" ]

[ 689 ]

1

[]

0

[]

0

[ "PUB00009409" ]

[ "9334165" ]

[ "A classification of nucleotide-diphospho-sugar glycosyltransferases based on amino acid sequence similarities." ]

[ 1997 ]

1

[]

0

null

[ "Bacteria", "Candidatus Methanoperedens nitratireducens", "ecological metagenomes" ]

[ 684, 1, 4 ]

3

[]

0

true

Family

Glycosyl transferase, family 28, RedA, predicted

Glyco_trans_28_RedA_prd

5

IPR016684

16,684

Type III secretion system chaperone, YscY

T3SS_YscY

Family

120

false

This group represents a type III secretion machinery chaperone protein, YscY type. YscY from Yersinia pestis is required for Yop virulence proteins secretion. It probably functions as a chaperone which stabilises YscX within the cell, before its secretion [ ]. AscY is the homologue in Aeromonas salmonicida [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF017117" ]

[ "T3SS_YscY" ]

[ 120 ]

1

[]

0

[ "7qih", "7qii", "7qij", "8ara", "8arb", "8arc" ]

6

[ "PUB00062146", "PUB00062147" ]

[ "10714987", "12374830" ]

[ "The Yersinia pestis YscY protein directly binds YscX, a secreted component of the type III secretion machinery.", "Evidence for a type III secretion system in Aeromonas salmonicida subsp. salmonicida." ]

[ 2000, 2002 ]

2

[]

0

null

[ "Bacteria" ]

[ 120 ]

1

[]

0

true

Family

Type III secretion system chaperone, YscY

T3SS_YscY

6

IPR016685

16,685

RNA-induced silencing complex, nuclease component Tudor-SN

Silence_cplx_Nase-comp_TudorSN

Family

4,161

false

This entry represents the Tudor staphylococcal nuclease (Tudor-SN) subunit of the RNA-induced silencing complex (RISC) [ , ]. RISC is central to the mechanism of RNA interference (RNAi), which is triggered by the presence of dsRNA, resulting in silencing of the cognate gene. In RNAi, dsRNA is processed by RNase III rib...

[ "GO:0031047", "GO:0031332" ]

[ "regulatory ncRNA-mediated gene silencing", "RNAi effector complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF017179" ]

[ "RISC-Tudor-SN" ]

[ 4161 ]

1

[ "EC", "REACTOME" ]

[ "3.1.31.1", "R-HSA-6802952" ]

[ "EC:3.1.31.1", "REACTOME:R-HSA-6802952" ]

2

[]

0

[ "PUB00042723", "PUB00042725" ]

[ "15895094", "17715366" ]

[ "The RISC subunit Tudor-SN binds to hyper-edited double-stranded RNA and promotes its cleavage.", "Tudor nuclease genes and programmed DNA rearrangements in Tetrahymena thermophila." ]

[ 2005, 2007 ]

2

[]

0

null

[ "Eukaryota" ]

[ 4161 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Schizosaccharomyces pombe (stra...

[ 6, 1, 2, 1, 6, 4, 1, 6, 5, 1, 11 ]

11

true

Family

RNA-induced silencing complex, nuclease component Tudor-SN

Silence_cplx_Nase-comp_TudorSN

7

IPR016686

16,686

Ribosome biogenesis factor, NIP7

Ribosomal_synth_fac_NIP7

Family

3,853

false

This entry represents 60S ribosome subunit biogenesis protein Nip7, which is required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly [ ]. In yeast, Nip7 interacts with nucleolar proteins such as Nol8 [ ], and with the exosome subunit Rrp43p. Nip7 contains a PUA domain.

[ "GO:0042255", "GO:0005634" ]

[ "ribosome assembly", "nucleus" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF017190" ]

[ "Rbsml_synth_fac_NIP7" ]

[ 3853 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-6791226", "R-MMU-6791226", "R-RNO-6791226", "R-SSC-6791226" ]

[ "REACTOME:R-HSA-6791226", "REACTOME:R-MMU-6791226", "REACTOME:R-RNO-6791226", "REACTOME:R-SSC-6791226" ]

4

[ "1sqw", "1t5y", "6elz", "6em5", "7nac", "7ohr", "7r6k", "7r7a", "7r7c", "8esq", "8esr", "8fkt", "8fku", "8fkv", "8fkw", "8fkx", "8fky", "8i9r", "8i9t", "8i9v", "8i9w", "8i9x", "8i9y", "8i9z", "8ia0", "8v83", "8v84", "8v87" ]

28

[ "PUB00042704", "PUB00042705" ]

[ "18001138", "15132771" ]

[ "Structural insights into the interaction of the Nip7 PUA domain with polyuridine RNA.", "Identification of NOL8, a nucleolar protein containing an RNA recognition motif (RRM), which was overexpressed in diffuse-type gastric cancer." ]

[ 2007, 2004 ]

2

[]

0

null

[ "Archaea", "Eukaryota", "marine sediment metagenome" ]

[ 5, 3844, 4 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 2, 1, 1, 1, 1, 3, 2, 1, 1, 2 ]

12

true

Family

Ribosome biogenesis factor, NIP7

Ribosomal_synth_fac_NIP7

3

IPR016688

16,688

Mechanosensitive ion channel MscS-like, plants/fungi

MscS-like_plants/fungi

Family

6,499

false

This entry represents a group of MscS-like (mechanosensitive channels of small conductance-like) proteins found in fungi and plants. Ten MscS-Like (MSL) proteins have been found in the genome of Arabidopsis thaliana [ , ]. In the fission yeast Schizosaccharomyces pombe the mechanosensitive ion channel proteins are know...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF017209", "PTHR31618" ]

[ "Memb_At2g17000_prd", "" ]

[ 4388, 5202 ]

2

[]

0

[ "7n5d", "7n5e", "7n5f", "7n5g", "8jwe", "8tdj", "8tdk", "8tdl", "8tdm" ]

9

[ "PUB00013956", "PUB00013957", "PUB00057878", "PUB00057879", "PUB00089654" ]

[ "12446901", "12626684", "19704841", "18485707", "22910366" ]

[ "Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel.", "Two families of mechanosensitive channel proteins.", "AtMSL9 and AtMSL10: Sensors of plasma membrane tension in Arabidopsis roots.", "Two MscS homologs provide mechanosensitive channel activities in the Arabidops...

[ 2002, 2003, 2008, 2008, 2012 ]

5

[]

0

null

[ "Eukaryota" ]

[ 6499 ]

1

[ "Arabidopsis thaliana", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 34, 2, 9, 2, 36 ]

5

true

Family

Mechanosensitive ion channel MscS-like, plants/fungi

MscS-like_plants/fungi

9

IPR016689

16,689

ESCRT-2 complex, Snf8

ESCRT-2_cplx_Snf8

Family

4,491

false

Snf8 (also known as Vps22p/Eap30) is a subunit of ESCRT-II, a protein complex involved in driving protein sorting from endosomes to lysosomes. The multivesicular body (MVB) protein-sorting pathway targets transmembrane proteins either for degradation or for function in the vacuole/lysosomes. The signal for entry into t...

[ "GO:0071985", "GO:0000814" ]

[ "multivesicular body sorting pathway", "ESCRT II complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF", "PANTHER" ]

[ "PIRSF017215", "PTHR12806" ]

[ "ESCRT2_Vps22", "" ]

[ 2959, 4491 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-917729", "R-DRE-917729", "R-HSA-917729", "R-HSA-9610379", "R-MMU-917729", "R-RNO-917729", "R-SCE-917729", "R-SPO-917729" ]

[ "REACTOME:R-DDI-917729", "REACTOME:R-DRE-917729", "REACTOME:R-HSA-917729", "REACTOME:R-HSA-9610379", "REACTOME:R-MMU-917729", "REACTOME:R-RNO-917729", "REACTOME:R-SCE-917729", "REACTOME:R-SPO-917729" ]

8

[ "1u5t", "1w7p", "2zme", "3cuq" ]

4

[ "PUB00087727" ]

[ "17450176" ]

[ "The emerging shape of the ESCRT machinery." ]

[ 2007 ]

1

[ "IPR040608" ]

[]

1

0

1

[ "Eukaryota", "Promethearchaeati", "unclassified sequences" ]

[ 4477, 7, 7 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 9, 1, 2, 1, 5, 2, 1, 5, 6, 1, 1, 3 ]

12

true

Family

ESCRT-2 complex, Snf8

ESCRT-2_cplx_Snf8

4

IPR016690

16,690

TSEN34

Family

2,184

false

TSEN34 constitutes one of the two catalytic subunits of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA [ ].

[ "GO:0000213", "GO:0000379", "GO:0000214" ]

[ "tRNA-intron lyase activity", "tRNA-type intron splice site recognition and cleavage", "tRNA-intron endonuclease complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF017250" ]

[ "tRNA_splic_SEN34" ]

[ 2184 ]

1

[ "EC", "METACYC", "METACYC", "REACTOME" ]

[ "4.6.1.16", "PWY-6689", "PWY-7803", "R-HSA-6784531" ]

[ "EC:4.6.1.16", "METACYC:PWY-6689", "METACYC:PWY-7803", "REACTOME:R-HSA-6784531" ]

4

[ "7uxa", "7zrz", "8hmy", "8hmz", "8iss" ]

5

[ "PUB00044697" ]

[ "15109492" ]

[ "Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3' end formation." ]

[ 2004 ]

1

[ "IPR006676" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2184 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 3, 3, 8, 3, 1, 3, 1, 1 ]

8

true

Family

TSEN34

1

IPR016691

16,691

tRNA (guanine(10)-N(2))-methyltransferase TRMT11

TRMT11

Family

4,295

false

tRNA (guanine(10)-N(2))-methyltransferase (TRMT11) is a catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs [ ]. These proteins are involved in the post-transcriptional modification of tRNA mol...

[ "GO:0160102" ]

[ "tRNA (guanine(10)-N2)-methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PROFILE" ]

[ "PS51627" ]

[ "SAM_MT_TRM11" ]

[ 4295 ]

1

[ "EC", "METACYC", "REACTOME" ]

[ "2.1.1.214", "PWY-6829", "R-HSA-6782315" ]

[ "EC:2.1.1.214", "METACYC:PWY-6829", "REACTOME:R-HSA-6782315" ]

3

[]

0

[ "PUB00006319", "PUB00020491", "PUB00054125", "PUB00057957", "PUB00057958" ]

[ "7897657", "15899842", "12826405", "16225687", "21858014" ]

[ "Universal catalytic domain structure of AdoMet-dependent methyltransferases.", "Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA.", "Many paths to methyltransfer: a chronicle of convergence.", "Natural history of S-adenosylmethionine-binding proteins.",...

[ 1995, 2005, 2003, 2005, 2011 ]

5

[]

0

null

[ "Eukaryota" ]

[ 4295 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 4, 1, 2, 1, 1, 2, 1, 1, 10, 1, 1, 3 ]

12

true

Family

tRNA (guanine(10)-N(2))-methyltransferase TRMT11

TRMT11

8

IPR016692

16,692

Sulfiredoxin

Family

2,303

false

Sulfiredoxins belong to the oxidoreductase family, which are involved in cellular responses to oxidative stress [ ]. They catalyse the reaction peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R It is a member of a conserved family of eukaryotic antiox...

[ "GO:0032542" ]

[ "sulfiredoxin activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF017267", "PTHR21348" ]

[ "Sulfiredoxin", "" ]

[ 1311, 2303 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.8.98.2", "R-DME-9818027", "R-HSA-9818027", "R-MMU-9818027", "R-SCE-9818027", "R-SPO-9818027" ]

[ "EC:1.8.98.2", "REACTOME:R-DME-9818027", "REACTOME:R-HSA-9818027", "REACTOME:R-MMU-9818027", "REACTOME:R-SCE-9818027", "REACTOME:R-SPO-9818027" ]

6

[ "1xw3", "1xw4", "1yzs", "2b6f", "2rii", "3cyi", "3hy2", "6ky4", "7lj1" ]

9

[ "PUB00053828" ]

[ "16102934" ]

[ "Sulfiredoxin: a potential therapeutic agent?" ]

[ 2005 ]

1

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 236, 2067 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 4, 5, 3, 1, 2, 3, 4, 1, 1, 9 ]

10

true

Family

Sulfiredoxin

1

IPR016694

16,694

Protein of unknown function UCP017292, zinc finger, CHY-type

UCP017292

Family

1,681

false

Proteins in this family contain a CHY-type zinc finger ( ). However, unlike other CHY domain-containing proteins, these do not also contain a RING-type zinc finger ( ). Most of the proteins in this entry are from bacteria, however, some eukaryotic proteins in this entry have been characterised, such as Hot13 (helper of...

[]

0

[ "PIRSF" ]

[ "PIRSF017292" ]

[ "UCP017292_Znf_CHY" ]

[ 1681 ]

1

[]

0

[]

0

[ "PUB00017071" ]

[ "15294910" ]

[ "The role of Hot13p and redox chemistry in the mitochondrial TIM22 import pathway." ]

[ 2004 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Stenosarchaea group", "metagenomes" ]

[ 1355, 190, 133, 3 ]

4

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

Protein of unknown function UCP017292, zinc finger, CHY-type

UCP017292

3

IPR016695

16,695

Purine 5'-nucleotidase

Pur_nucleotidase

Family

7,728

false

This entry includes cytosolic purine 5'-nucleotidases and 5'-nucleotidase domain-containing proteins. Cytosolic purine 5'-nucleotidases, also known as cytosolic 5'-nucleotidase II (cN-II), is an IMP/GMP preferring 5'-nucleotidase that can function as a phosphatase and a phosphotransferase, and these activities might co...

[]

0

[ "PIRSF" ]

[ "PIRSF017434" ]

[ "Purine_5'-nucleotidase" ]

[ 7728 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.3", "R-BTA-2161541", "R-BTA-74259", "R-BTA-9755088", "R-DDI-2161541", "R-DDI-74259", "R-DDI-9755088", "R-GGA-421178", "R-HSA-2161541", "R-HSA-74259", "R-HSA-9755088", "R-MMU-2161541", "R-MMU-74259", "R-MMU-9755088", "R-RNO-2161541", "R-RNO-74259", "R-RNO-9755088", "R-XTR-21615...

[ "EC:3.1.3", "REACTOME:R-BTA-2161541", "REACTOME:R-BTA-74259", "REACTOME:R-BTA-9755088", "REACTOME:R-DDI-2161541", "REACTOME:R-DDI-74259", "REACTOME:R-DDI-9755088", "REACTOME:R-GGA-421178", "REACTOME:R-HSA-2161541", "REACTOME:R-HSA-74259", "REACTOME:R-HSA-9755088", "REACTOME:R-MMU-2161541", "...

20

[ "2bde", "2j2c", "2jc9", "2jcm", "2xcv", "2xcw", "2xcx", "2xjb", "2xjc", "2xjd", "2xje", "2xjf", "4g63", "4h4b", "4ohf", "5cqz", "5cr7", "5k7y", "5l4z", "5l50", "5opk", "5opl", "5opm", "5opn", "5opo", "5opp", "6dd3", "6ddb", "6ddc", "6ddh", "6ddk", "6ddl"...

46

[ "PUB00085078" ]

[ "25811392" ]

[ "Cytosolic 5'-nucleotidase II interacts with the leucin rich repeat of NLR family member Ipaf." ]

[ 2015 ]

1

[ "IPR008380" ]

[]

1

0

1

[ "Bacteria", "Eukaryota" ]

[ 307, 7421 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 14, 3, 12, 5, 9, 11, 6, 10, 14 ]

9

true

Family

Purine 5'-nucleotidase

Pur_nucleotidase

3

IPR016696

16,696

TRAPP I complex, subunit 5

TRAPP-I_su5

Family

4,338

false

TRS31 (also known as TRAPPC5) is a subunit of the trafficking protein particle complex (TRAPP). It is one of the six core subunits of TRAPP complexes which play a key role in the regulation of ER-to-Golgi and intra-Golgi transport by tethering the vesicle membrane to the target membrane [ , , , , ].

[ "GO:0048193", "GO:0030008" ]

[ "Golgi vesicle transport", "TRAPP complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF", "PANTHER", "CDD" ]

[ "PIRSF017479", "PTHR20902", "cd14943" ]

[ "TRAPP_I_complex_Trs31", "", "TRAPPC5_Trs31" ]

[ 3589, 4266, 4138 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-204005", "R-DDI-8876198", "R-HSA-204005", "R-HSA-8876198", "R-MMU-204005", "R-MMU-8876198", "R-PFA-204005", "R-PFA-8876198", "R-SCE-204005", "R-SCE-8876198", "R-SPO-204005", "R-SPO-8876198" ]

[ "REACTOME:R-DDI-204005", "REACTOME:R-DDI-8876198", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-8876198", "REACTOME:R-MMU-204005", "REACTOME:R-MMU-8876198", "REACTOME:R-PFA-204005", "REACTOME:R-PFA-8876198", "REACTOME:R-SCE-204005", "REACTOME:R-SCE-8876198", "REACTOME:R-SPO-204005", "REACTOME:R-SP...

12

[ "2j3r", "2j3w", "3cue", "7aor", "7b6d", "7b6r", "7b6x", "7b70", "7e2c", "7e2d", "7e8s", "7e8t", "7e93", "7e94", "7ea3", "7kmt", "7u05", "7u06" ]

18

[ "PUB00020479", "PUB00041864", "PUB00055565", "PUB00080272", "PUB00080273" ]

[ "9564032", "17110339", "18801063", "22669257", "20966969" ]

[ "TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion.", "The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering.", "The TRAPP complex: insights into its architecture and function.", "A trapper keeper for TRAPP, its structures a...

[ 1998, 2006, 2008, 2012, 2010 ]

5

[ "IPR007194" ]

[]

1

0

1

[ "Eukaryota" ]

[ 4338 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 2, 1, 1, 1, 2, 1, 1, 2, 3, 1, 1, 5 ]

12

true

Family

TRAPP I complex, subunit 5

TRAPP-I_su5

6

IPR016697

16,697

Aquaporin 11/12

Aquaporin_11/12

Family

2,098

false

Aquaporins 11 and 12 are classified as members of a new AQP subfamily: the subcellular AQPs [ ]. AQP 11 and 12 appear to be more distantly related to the other mammalian aquaporins and aquaglyceroporins. AQP11 is functionally distinct from other proteins of the aquaporin superfamily and could represent a new aquaporin ...

[]

0

[ "PIRSF" ]

[ "PIRSF017529" ]

[ "Aquaporin_11/12" ]

[ 2098 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-432047", "R-HSA-432047", "R-MMU-432047", "R-RNO-432047" ]

[ "REACTOME:R-CEL-432047", "REACTOME:R-HSA-432047", "REACTOME:R-MMU-432047", "REACTOME:R-RNO-432047" ]

4

[]

0

[ "PUB00043535", "PUB00043536", "PUB00043537", "PUB00043538", "PUB00043539" ]

[ "16650285", "18067818", "18419953", "17526024", "17178102" ]

[ "Aquaporin-11: a channel protein lacking apparent transport function expressed in brain.", "[Effect of hypertonic medium on expression of aquaporin-1 in pleural mesothelial cells: experiment with rats]", "[Expression of renal aquaporin 2 after circulatory arrest]", "Aquaporin 9 changes in pyramidal cells befo...

[ 2006, 2007, 2008, 2007, 2007 ]

5

[ "IPR000425" ]

[ "IPR023265", "IPR023266" ]

1

2

0

[ "Bilateria" ]

[ 2098 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 2, 4, 3, 6 ]

6

true

Family

Aquaporin 11/12

Aquaporin_11/12

6

IPR016698

16,698

Numb/numb-like

Family

3,895

false

This group represents Protein numb and similar proteins from animals. This protein plays key roles in cell fate determination [ ]. Members of this protein family contain a PID domain, a type of PTB domain [ ]. NUMB from Drosophila is required in determination of cell fate during sensory organ formation in embryos [ ]. ...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF017607", "PTHR47368" ]

[ "Numb/numb-like", "" ]

[ 2548, 3895 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2122948", "R-HSA-437239", "R-HSA-5610780", "R-HSA-5632684", "R-HSA-9725554", "R-MMU-437239", "R-MMU-5610780", "R-MMU-5632684", "R-RNO-437239", "R-RNO-5610780", "R-RNO-5632684" ]

[ "REACTOME:R-HSA-2122948", "REACTOME:R-HSA-437239", "REACTOME:R-HSA-5610780", "REACTOME:R-HSA-5632684", "REACTOME:R-HSA-9725554", "REACTOME:R-MMU-437239", "REACTOME:R-MMU-5610780", "REACTOME:R-MMU-5632684", "REACTOME:R-RNO-437239", "REACTOME:R-RNO-5610780", "REACTOME:R-RNO-5632684" ]

11

[ "1ddm", "1wj1", "2nmb", "3f0w", "5njj", "5njk", "5yi7", "5yi8", "5yqg" ]

9

[ "PUB00018031", "PUB00073536", "PUB00073537", "PUB00073538", "PUB00073539", "PUB00073542", "PUB00073543", "PUB00099900", "PUB00099901" ]

[ "15567406", "2752427", "12194846", "16113648", "11134024", "22701667", "22593207", "19944684", "30726988" ]

[ "Structural and evolutionary division of phosphotyrosine binding (PTB) domains.", "numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos.", "Numb: \"Adapting\" notch for endocytosis.", "Numb and alpha-Adaptin regulate Sanpodo endocytosis to specify cell fate ...

[ 2005, 1989, 2002, 2005, 2001, 2012, 2012, 2010, 2019 ]

9

[]

0

null

[ "Eukaryota" ]

[ 3895 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 7, 2, 20, 10, 15 ]

6

true

Family

Numb/numb-like

1

IPR016699

16,699

Acid ceramidase-like

Acid_ceramidase-like

Family

2,523

false

This group represents acid ceramidases and some related proteins of currently unknown function. Ceramide is hydrolyzed by both acid and alkaline ceramidase [ ]. Acid ceramidase requires saposin D, a sphingolipid activator protein, for the lysosomal breakdown of ceramide to a fatty acid and sphingosine [ ]. Ceramide is ...

[ "GO:0017064", "GO:0006631", "GO:0005764" ]

[ "fatty acid amide hydrolase activity", "fatty acid metabolic process", "lysosome" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF017632" ]

[ "Acid_ceramidase-like" ]

[ 2523 ]

1

[ "EC", "EC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.5.1", "3.5.1.23", "PWY-6483", "PWY-7119", "R-BTA-6798695", "R-BTA-9840310", "R-CEL-112310", "R-CEL-6798695", "R-CEL-9840310", "R-HSA-112310", "R-HSA-6798695", "R-HSA-9840310", "R-HSA-9857377", "R-MMU-112310", "R-MMU-6798695", "R-MMU-9840310", "R-RNO-112310", "R-RNO-6798695", "...

[ "EC:3.5.1", "EC:3.5.1.23", "METACYC:PWY-6483", "METACYC:PWY-7119", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-9840310", "REACTOME:R-CEL-112310", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-9840310", "REACTOME:R-HSA-112310", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-9840310", "REACTOME:R-HSA-985...

19

[ "5u81", "5u84", "6dxw" ]

3

[ "PUB00043403", "PUB00043404", "PUB00094738", "PUB00094739" ]

[ "8203897", "18453694", "8955159", "22703880" ]

[ "Stimulation of acid ceramidase activity by saposin D.", "Structures of the human ceramide activator protein saposin D.", "Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification Of the first molecular lesion causing Farber disease.", "Spinal mu...

[ 1994, 2008, 1996, 2012 ]

4

[]

0

null

[ "Eukaryota", "Mimivirus", "viral metagenome" ]

[ 2517, 5, 1 ]

3

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 2, 14, 8, 6 ]

5

true

Family

Acid ceramidase-like

Acid_ceramidase-like

5

IPR016700

16,700

3-hydroxyanthranilate 3, 4-dioxygenase, metazoan

3hydroanth_dOase_met

Family

577

false

This group represents a 3-hydroxyanthranilate 3,4-dioxygenase found in metazoan species, especially animals. 3-Hydroxyanthranilic acid 3,4-dioxygenase (3HAO) is a non-heme ferrous extradiol dioxygenase in the kynurenine pathway from tryptophan. It catalyzes the conversion of 3-hydroxyanthranilate (HAA) to quinolinic ac...

[ "GO:0000334", "GO:0046872", "GO:0005737" ]

[ "3-hydroxyanthranilate 3,4-dioxygenase activity", "metal ion binding", "cytoplasm" ]

[ "molecular_function", "molecular_function", "cellular_component" ]

3

[ "PIRSF" ]

[ "PIRSF017681" ]

[ "3hydroanth_dOase_animal" ]

[ 577 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "1.13.11.6", "PWY-5647", "PWY-5651", "PWY-6309", "PWY-6505", "R-CEL-71240", "R-DRE-71240", "R-HSA-71240", "R-MMU-71240", "R-RNO-71240", "R-XTR-71240" ]

[ "EC:1.13.11.6", "METACYC:PWY-5647", "METACYC:PWY-5651", "METACYC:PWY-6309", "METACYC:PWY-6505", "REACTOME:R-CEL-71240", "REACTOME:R-DRE-71240", "REACTOME:R-HSA-71240", "REACTOME:R-MMU-71240", "REACTOME:R-RNO-71240", "REACTOME:R-XTR-71240" ]

11

[ "2qnk", "3fe5", "5tk5", "5tkq" ]

4

[ "PUB00043312", "PUB00043313" ]

[ "16522801", "1422788" ]

[ "Crystal structure of 3-hydroxyanthranilic acid 3,4-dioxygenase from Saccharomyces cerevisiae: a special subgroup of the type III extradiol dioxygenases.", "Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease." ]

[ 2006, 1992 ]

2

[ "IPR010329" ]

[]

1

0

1

[ "Metazoa" ]

[ 577 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 1, 1, 4 ]

5

true

Family

3-hydroxyanthranilate 3, 4-dioxygenase, metazoan

3hydroanth_dOase_met

6

IPR016702

16,702

ATP synthase, F0 complex, gamma subunit, metazoa

ATP5MG_metazoa

Family

1,655

false

This entry represents the mitochondrial ATP synthase subunit g (ATP5MG) from animals. Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type AT...

[]

0

[ "PIRSF" ]

[ "PIRSF017835" ]

[ "ATP-synth_g_mitoch_animal" ]

[ 1655 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-163210", "R-HSA-8949613", "R-HSA-9837999", "R-MMU-163210", "R-MMU-8949613", "R-MMU-9837999", "R-RNO-163210", "R-RNO-8949613", "R-RNO-9837999" ]

[ "REACTOME:R-HSA-163210", "REACTOME:R-HSA-8949613", "REACTOME:R-HSA-9837999", "REACTOME:R-MMU-163210", "REACTOME:R-MMU-8949613", "REACTOME:R-MMU-9837999", "REACTOME:R-RNO-163210", "REACTOME:R-RNO-8949613", "REACTOME:R-RNO-9837999" ]

9

[ "6tt7", "6za9", "6zbb", "6ziq", "6zit", "6ziu", "6zmr", "6zna", "6zpo", "6zqm", "6zqn", "7ajb", "7ajc", "7ajd", "7aje", "7ajf", "7ajg", "7ajh", "7aji", "7ajj", "8h9f", "8h9j", "8h9m", "8h9q", "8h9s", "8h9t", "8h9u", "8h9v", "8khf", "8ki3", "9b0x", "9b3j"...

35

[ "PUB00009752", "PUB00090176" ]

[ "11309608", "20833715" ]

[ "Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.", "Structure of dimeric F1F0-ATP synthase." ]

[ 2001, 2010 ]

2

[ "IPR006808" ]

[]

1

0

1

[ "Eukaryota", "Pantoea vagans" ]

[ 1654, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 1, 2, 3, 3, 3 ]

6

true

Family

ATP synthase, F0 complex, gamma subunit, metazoa

ATP5MG_metazoa

2

IPR016703

16,703

Conjugal transfer, TraD, beta/gamma-type

Conjugal_tfr_TraD_b/g-type

Family

116

false

This group represents a group of conjugal transfer TraD proteins found almost exclusively in the beta and gamma proteobacteria.

[]

0

[ "PIRSF" ]

[ "PIRSF017849" ]

[ "Conjugal_transfer_TraD" ]

[ 116 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "plasmids" ]

[ 109, 7 ]

2

[]

0

true

Family

Conjugal transfer, TraD, beta/gamma-type

Conjugal_tfr_TraD_b/g-type

9

IPR016704

16,704

Conjugal transfer, TrbD

Conjugal_tfr_TrbD

Family

2,901

false

This group represents the plasmid conjugal transfer protein TrbD.

[]

0

[ "PIRSF" ]

[ "PIRSF017854" ]

[ "T4SS_TrbD" ]

[ 2901 ]

1

[]

0

[]

0

[]

0

[ "IPR007792" ]

[]

1

0

1

[ "Bacteria", "metagenomes", "plasmids" ]

[ 2872, 21, 8 ]

3

[]

0

true

Family

Conjugal transfer, TrbD

Conjugal_tfr_TrbD

4

IPR016705

16,705

Photosynthesis system II assembly factor Ycf48/Hcf136

Ycf48/Hcf136

Family

745

false

This entry represents a family of proteins predominantly found in the thylakoid membrane of plant chloroplasts and cyanobacteria, including Photosystem II assembly lipoprotein Ycf48 from Synechocystis sp. [ , ] and Photosystem II stability/assembly factor HCF136, chloroplastic from Arabidopsis thaliana [ ]. The photosy...

[]

0

[ "HAMAP", "PIRSF" ]

[ "MF_01348", "PIRSF017875" ]

[ "Ycf48", "PSII_HCF136" ]

[ 381, 742 ]

2

[]

0

[ "2xbg", "5oj5", "5ojp", "5ojr", "8am5", "8asl" ]

6

[ "PUB00067686", "PUB00067687", "PUB00101110", "PUB00101111" ]

[ "18550538", "21531723", "12459468", "30061392" ]

[ "The cyanobacterial homologue of HCF136/YCF48 is a component of an early photosystem II assembly complex and is important for both the efficient assembly and repair of photosystem II in Synechocystis sp. PCC 6803.", "An intermediate membrane subfraction in cyanobacteria is involved in an assembly network for Phot...

[ 2008, 2011, 2002, 2018 ]

4

[]

0

null

[ "Cyanobacteriota", "Eukaryota" ]

[ 368, 377 ]

2

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 4 ]

3

true

Family

Photosynthesis system II assembly factor Ycf48/Hcf136

Ycf48/Hcf136

6

IPR016707

16,707

Conjugal transfer, TraB, rhizobiales

Conjugal_tfr_TraB_rhizob

Family

400

false

This family consists of several TraB proteins, which seem to be found exclusively in Agrobacterium species. TraB is known to be involved in conjugal transfer [ ].

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "NCBIFAM", "PIRSF" ]

[ "NF010398", "PIRSF017932" ]

[ "PRK13825.1-2", "Conjugal_transfer_TraB_rhizob" ]

[ 400, 331 ]

2

[ "GP" ]

[ "GenProp0490" ]

[ "GP:GenProp0490" ]

1

[]

0

[ "PUB00012375" ]

[ "8763953" ]

[ "The tra region of the nopaline-type Ti plasmid is a chimera with elements related to the transfer systems of RSF1010, RP4, and F." ]

[ 1996 ]

1

[]

0

null

[ "Alphaproteobacteria" ]

[ 400 ]

1

[]

0

true

Family

Conjugal transfer, TraB, rhizobiales

Conjugal_tfr_TraB_rhizob

8

IPR016708

16,708

Aspartoacylase

Family

2,103

false

Aspartoacylase (ASPA) is the N-acetylaspartate- (NAA)-hydrolysing enzyme. It catalyses the deacetylation of N-acetyl-L-aspartate to produce L-aspartate and acetate. N-phosphonomethyl-L-aspartate is a potent inhibitor of this enzyme [ ]. There is a high concentration of (NAA) in neurons of the central nervous system, wh...

[ "GO:0016811" ]

[ "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides" ]

[ "molecular_function" ]

1

[ "HAMAP", "NCBIFAM", "PIRSF" ]

[ "MF_00704", "NF002601", "PIRSF018001" ]

[ "Aspartoacylase", "PRK02259.1", "Aspartoacylase" ]

[ 1797, 2024, 1897 ]

3

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.5.1.15", "R-DRE-5423646", "R-DRE-8963693", "R-HSA-5423646", "R-HSA-8963693", "R-MMU-5423646", "R-MMU-8963693", "R-RNO-5423646", "R-RNO-8963693", "R-XTR-5423646", "R-XTR-8963693" ]

[ "EC:3.5.1.15", "REACTOME:R-DRE-5423646", "REACTOME:R-DRE-8963693", "REACTOME:R-HSA-5423646", "REACTOME:R-HSA-8963693", "REACTOME:R-MMU-5423646", "REACTOME:R-MMU-8963693", "REACTOME:R-RNO-5423646", "REACTOME:R-RNO-8963693", "REACTOME:R-XTR-5423646", "REACTOME:R-XTR-8963693" ]

11

[ "2gu2", "2i3c", "2o4h", "2o53", "2q4z", "2q51", "3nfz", "3nh4", "3nh5", "3nh8", "4mri", "4mxu", "4nfr", "4tnu" ]

14

[ "PUB00043513", "PUB00043514" ]

[ "18293939", "18478328" ]

[ "Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue.", "Myelin Lipid Abnormalities in the Aspartoacylase-Deficient Tremor Rat." ]

[ 2008, 2008 ]

2

[ "IPR050178" ]

[]

1

0

1

[ "Bacteria", "Eukaryota" ]

[ 598, 1505 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 4, 2, 11 ]

4

true

Family

Aspartoacylase

2

IPR016709

16,709

Dehydratase subunit HadA-like

HadA-like

Family

6,200

false

This protein family includes HadA from Mycobacterium tuberculosis (Rv0636, ), HadA from Mycolicibacterium smegmatis (MSMEG_1340, ) and other bacterial proteins from the UPF0336 family. HadA is a component of the beta-hydroxyacyl-ACP dehydratase HadAB complex. It adopts a hotdog fold with a central β-sheet, which is twi...

[]

0

[ "HAMAP", "PIRSF" ]

[ "MF_00799", "PIRSF018072" ]

[ "UPF0336", "UCP018072" ]

[ 3968, 6022 ]

2

[]

0

[ "4rlj", "4rlt", "4rlu", "4rlw", "4rv2", "5zy8", "7svt", "8pwz", "8y21" ]

9

[ "PUB00100976", "PUB00100977" ]

[ "25656575", "26081470" ]

[ "Crystal structure of dehydratase component HadAB complex of mycobacterial FAS-II pathway.", "Molecular basis for the inhibition of β-hydroxyacyl-ACP dehydratase HadAB complex from Mycobacterium tuberculosis by flavonoid inhibitors." ]

[ 2015, 2015 ]

2

[]

0

null

[ "Bacteria", "Halobacteriales", "metagenomes" ]

[ 6116, 8, 76 ]

3

[]

0

true

Family

Dehydratase subunit HadA-like

HadA-like

9

IPR016710

16,710

Emp46/Emp47

Family

52

false

This entry includes Emp46 and its paralogue, Emp47, from budding yeasts. They are integral membrane components of ER-derived COPII-coated vesicles. They are involved in the secretion of glycoproteins and functions in ER to Golgi transport [ ].

[ "GO:0006888", "GO:0016020" ]

[ "endoplasmic reticulum to Golgi vesicle-mediated transport", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF" ]

[ "PIRSF018136" ]

[ "L-type_lectin_fungi" ]

[ 52 ]

1

[ "REACTOME" ]

[ "R-SCE-9013106" ]

[ "REACTOME:R-SCE-9013106" ]

1

[]

0

[ "PUB00074956" ]

[ "12134087" ]

[ "Emp47p and its close homolog Emp46p have a tyrosine-containing endoplasmic reticulum exit signal and function in glycoprotein secretion in Saccharomyces cerevisiae." ]

[ 2002 ]

1

[]

0

null

[ "Saccharomycotina" ]

[ 52 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2 ]

1

true

Family

Emp46/Emp47

9

IPR016711

16,711

Sds23

Ssd23

Family

886

false

This entry represents the fungal Sds23 protein, also known as Moc1 or Psp1. The exact function of this protein is not known but it is thought to be required for proper DNA replication and mitosis [ , ]. It has also been shown to induce sexual development [ , ] and is involved in the response to nutrient deprivation str...

[ "GO:0030071", "GO:0042149" ]

[ "regulation of mitotic metaphase/anaphase transition", "cellular response to glucose starvation" ]

[ "biological_process", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF018148" ]

[ "UCP018148_CBS_YBR214w" ]

[ 886 ]

1

[]

0

[]

0

[ "PUB00042667", "PUB00042668", "PUB00042669", "PUB00074616", "PUB00074617", "PUB00074618" ]

[ "8978689", "9242669", "16273369", "16041152", "16819157", "23640764" ]

[ "Requirement for PP1 phosphatase and 20S cyclosome/APC for the onset of anaphase is lessened by the dosage increase of a novel gene sds23+.", "A novel protein, Psp1, essential for cell cycle progression of Schizosaccharomyces pombe is phosphorylated by Cdc2-Cdc13 upon entry into G0-like stationary phase of cell g...

[ 1996, 1997, 2005, 2005, 2006, 2013 ]

6

[]

0

null

[ "Dikarya" ]

[ 886 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 2, 1 ]

3

true

Family

Sds23

Ssd23

9

IPR016712

16,712

Small ribosomal subunit protein bS1m-like

Rbsml_bS1m-like

Family

1,706

false

This entry represents the small ribosomal subunit protein bS1m from yeast and similar fungal sequences. bS1m, previously known as MRP51, is a component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at lea...

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF11709", "PIRSF018156", "PTHR28058" ]

[ "Mit_ribos_Mrp51", "MRPL51_fungal", "" ]

[ 1654, 97, 1690 ]

3

[]

0

[ "5mrc", "5mre", "5mrf", "6yw5", "6ywe", "6ywx", "6ywy", "8d8k", "8d8l", "8om2", "8om3", "8om4" ]

12

[ "PUB00044889", "PUB00056068", "PUB00089004", "PUB00098057" ]

[ "16303567", "9528754", "25609543", "28154081" ]

[ "A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.", "Functional interactions between yeast mitochondrial ribosomes and mRNA 5' untranslated leaders.", "Organization of the mitochondrial translation machinery studied in situ by cryoelectron tomography.", "The ...

[ 2005, 1998, 2015, 2017 ]

4

[]

0

null

[ "Eukaryota" ]

[ 1706 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 1, 1, 2, 1 ]

4

true

Family

Small ribosomal subunit protein bS1m-like

Rbsml_bS1m-like

4

IPR016713

16,713

Poly(A) polymerase complex subunit Air1/2, budding yeast

Air1/2_Saccharomycetales

Family

130

false

This group represents a poly(A) polymerase complex Air1/2 subunits from budding yeasts [ ]. They are components of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information [ , ].

[ "GO:0043633" ]

[ "polyadenylation-dependent RNA catabolic process" ]

[ "biological_process" ]

1

[ "PIRSF" ]

[ "PIRSF018162" ]

[ "PolyA_pol_Air1/2" ]

[ 130 ]

1

[]

0

[]

0

[ "PUB00073552", "PUB00073553", "PUB00073554" ]

[ "15828860", "10896665", "15935758" ]

[ "A new yeast poly(A) polymerase complex involved in RNA quality control.", "Novel RING finger proteins, Air1p and Air2p, interact with Hmt1p and inhibit the arginine methylation of Npl3p.", "RNA degradation by the exosome is promoted by a nuclear polyadenylation complex." ]

[ 2005, 2000, 2005 ]

3

[]

0

null

[ "Ascomycota" ]

[ 130 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1 ]

2

true

Family

Poly(A) polymerase complex subunit Air1/2, budding yeast

Air1/2_Saccharomycetales

9

IPR016714

16,714

Mannan endo-1,4-beta-mannosidase B/E

MANB/E

Family

1,047

false

This group represents mannan endo-1,4-beta-mannosidase MANB from Bacillus subtilis and MANE from Emericella nidulans. It catalyses the endo hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans [ , ].

[ "GO:0016985", "GO:0006080" ]

[ "mannan endo-1,4-beta-mannosidase activity", "substituted mannan metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF018168" ]

[ "Mannan-1_4-beta-mannosidase" ]

[ 1047 ]

1

[ "EC", "METACYC" ]

[ "3.2.1.78", "PWY-7456" ]

[ "EC:3.2.1.78", "METACYC:PWY-7456" ]

2

[ "2qha", "2vx4", "2vx5", "2vx6", "2vx7", "2whk", "3cbw", "4zxo", "7eet" ]

9

[ "PUB00070135", "PUB00070770" ]

[ "18177310", "7727534" ]

[ "Glucomannan utilization operon of Bacillus subtilis.", "Cloning and sequencing of beta-mannanase gene from Bacillus subtilis NM-39." ]

[ 2008, 1995 ]

2

[ "IPR000805" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 1022, 12, 1, 12 ]

4

[]

0

true

Family

Mannan endo-1,4-beta-mannosidase B/E

MANB/E

8

IPR016715

16,715

Platelet-activating factor acetylhydrolase-like, eukaryote

PAF_acetylhydro_eukaryote

Family

3,660

false

Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipase A2, and is involved in regulation of inflammation through the inactivation of platelet-activating factor and polar phospholipids [ , , ]. This entry represents the platelet-activating factor acetylhydrolases from eukaryotes. It also inc...

[ "GO:0003847" ]

[ "1-alkyl-2-acetylglycerophosphocholine esterase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF018169" ]

[ "PAF_acetylhydrolase" ]

[ 3660 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.1.1.47", "R-BTA-418346", "R-CEL-418346", "R-HSA-418346", "R-HSA-422085", "R-MMU-418346", "R-MMU-422085", "R-RNO-418346", "R-SPO-418346" ]

[ "EC:3.1.1.47", "REACTOME:R-BTA-418346", "REACTOME:R-CEL-418346", "REACTOME:R-HSA-418346", "REACTOME:R-HSA-422085", "REACTOME:R-MMU-418346", "REACTOME:R-MMU-422085", "REACTOME:R-RNO-418346", "REACTOME:R-SPO-418346" ]

9

[ "3d59", "3d5e", "3f96", "3f97", "3f98", "3f9c", "5i8p", "5i9i", "5jad", "5jah", "5jal", "5jan", "5jao", "5jap", "5jar", "5jas", "5jat", "5jau", "5lp1", "5lyy", "5lz2", "5lz4", "5lz5", "5lz7", "5lz8", "5lz9", "5ye7", "5ye8", "5ye9", "5yea", "6m06", "6m07"...

33

[ "PUB00019983", "PUB00102525", "PUB00102526" ]

[ "9645224", "16371369", "17090529" ]

[ "The structure and function of platelet-activating factor acetylhydrolases.", "Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases.", "Phospholipase action of platelet-activating factor acetylhydrolase, but not paraox...

[ 1998, 2006, 2007 ]

3

[]

0

null

[ "Eukaryota" ]

[ 3660 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 2, 4, 8, 1, 11, 1 ]

7

true

Family

Platelet-activating factor acetylhydrolase-like, eukaryote

PAF_acetylhydro_eukaryote

9

IPR016716

16,716

Regulator of ribonuclease activity B

RraB

Family

2,074

false

Regulator of ribonuclease activity B (RraB) globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. It can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome [ , ].

[]

0

[ "HAMAP", "NCBIFAM", "PIRSF" ]

[ "MF_01888", "NF008393", "PIRSF018193" ]

[ "RraB", "PRK11191.1", "UCP018193" ]

[ 1980, 2074, 2016 ]

3

[]

0

[ "1nxi" ]

1

[ "PUB00035720", "PUB00056807" ]

[ "16771842", "18510556" ]

[ "Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome.", "Inhibitory effects of RraA and RraB on RNAse E-related enzymes imply conserved functions in the regulated enzymatic cleavage of RNA." ]

[ 2006, 2008 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta", "marine sediment metagenome" ]

[ 2069, 4, 1 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

Regulator of ribonuclease activity B

RraB

9

IPR016717

16,717

Gip2/Pig2

Family

26

false

This entry includes budding yeast Gip2 (GLC7-interacting protein 2) and its paralogue, Pig2 (Protein Interacting with Gsy2). Pig2 is is a putative type-1 protein phosphatase (PP1) targeting subunit that tethers the Glc7p type-1 protein phosphatase to the Gsy2p glycogen synthase [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF018234" ]

[ "PPase_interacting" ]

[ 26 ]

1

[ "REACTOME" ]

[ "R-SCE-3322077" ]

[ "REACTOME:R-SCE-3322077" ]

1

[]

0

[ "PUB00074600" ]

[ "11973298" ]

[ "Protein phosphatase type 1 regulates ion homeostasis in Saccharomyces cerevisiae." ]

[ 2002 ]

1

[]

0

null

[ "Saccharomycetaceae" ]

[ 26 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2 ]

1

true

Family

Gip2/Pig2

1

IPR016718

16,718

rRNA (guanine-N1-)-methyltransferase A, predicted

rRNA_m1G-MeTrfase_A_prd

Family

8,452

false

This entry represents proteins predicted to function as rRNA (guanine-N1-)-methyltransferases ( ). These enzymes specifically methylate the guanosine residue m1G in 23S rRNA. The rrmA gene was predicted to encode 23S rRNA m1G745 methyltransferase in Saccharomyces cerevisiae (Baker's yeast), and maps to the same locus a...

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF" ]

[ "PIRSF018249" ]

[ "MyrA_prd" ]

[ 8452 ]

1

[]

0

[ "1p91" ]

1

[ "PUB00042731" ]

[ "9440525" ]

[ "Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant." ]

[ 1998 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 8406, 4, 42 ]

3

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

rRNA (guanine-N1-)-methyltransferase A, predicted

rRNA_m1G-MeTrfase_A_prd

9

IPR016719

16,719

Guided entry of tail-anchored proteins factor CAMLG

CAMLG

Family

1,144

false

This entry represents the Guided entry of tail-anchored proteins factor CAMLG (also known as Calcium signal-modulating cyclophilin ligand CAML) which is required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum [ , , ]. Together with GET1/WRB, acts as a membrane receptor f...

[]

0

[ "PFAM", "PIRSF", "PANTHER" ]

[ "PF14963", "PIRSF018259", "PTHR15026" ]

[ "Get2_like", "CAML", "" ]

[ 1061, 607, 1109 ]

3

[ "REACTOME" ]

[ "R-HSA-9609523" ]

[ "REACTOME:R-HSA-9609523" ]

1

[ "6so5", "8cr1", "8cr2" ]

3

[ "PUB00044070", "PUB00097942", "PUB00097943", "PUB00097944", "PUB00097945", "PUB00098624" ]

[ "7522304", "24392163", "23041287", "32187542", "27226539", "25869254" ]

[ "Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.", "WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane.", "Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian c...

[ 1994, 2014, 2012, 2020, 2016, 2015 ]

6

[]

0

null

[ "Eumetazoa" ]

[ 1144 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 5, 2, 6 ]

4

true

Family

Guided entry of tail-anchored proteins factor CAMLG

CAMLG

3

IPR016720

16,720

Phosphatidate cytidylyltransferase, eukaryota

PC_Trfase_euk

Family

7,714

false

Cytidinediphosphate diacylglycerol synthase (CDS) is a membrane-bound enzyme that catalyzes the transfer of a cytidyl group from cytidine triphosphate (CTP) to phosphatidic acid (PA), producing cytidine diphosphate diacylglycerol (CDP-DAG), the important branch point intermediate in the glycerolipid biosynthesis of pro...

[ "GO:0004605" ]

[ "phosphatidate cytidylyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF018269", "PTHR13773" ]

[ "PC_trans_euk", "" ]

[ 5424, 7714 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.7.41", "PWY-5667", "PWY-5981", "PWY-7817", "R-BTA-1483148", "R-CEL-1483148", "R-CEL-1483226", "R-DDI-1483148", "R-DDI-1483226", "R-DME-1483148", "R-DME-1483226", "R-HSA-1483148", "R-HSA-1483226", "R-MMU-1483148", "R-MMU-1483226", "R-RNO-1483148", "R-RNO-1483226", "R-SCE-148314...

[ "EC:2.7.7.41", "METACYC:PWY-5667", "METACYC:PWY-5981", "METACYC:PWY-7817", "REACTOME:R-BTA-1483148", "REACTOME:R-CEL-1483148", "REACTOME:R-CEL-1483226", "REACTOME:R-DDI-1483148", "REACTOME:R-DDI-1483226", "REACTOME:R-DME-1483148", "REACTOME:R-DME-1483226", "REACTOME:R-HSA-1483148", "REACTOME...

21

[]

0

[ "PUB00092605" ]

[ "23711240" ]

[ "Extraplastidial cytidinediphosphate diacylglycerol synthase activity is required for vegetative development in Arabidopsis thaliana." ]

[ 2013 ]

1

[ "IPR000374" ]

[]

1

0

1

[ "Bacteria", "Eukaryota", "viral metagenome" ]

[ 7, 7706, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 13, 1, 2, 5, 6, 6, 1, 8, 7, 1, 1, 38 ]

12

true

Family

Phosphatidate cytidylyltransferase, eukaryota

PC_Trfase_euk

5

IPR016721

16,721

Bet3 family

Bet3

Family

5,343

false

This entry includes Bet3 (also known as TRAPPC3) and Bet3-like (TRAPPC3L) proteins from eukaryotes. They seem to be involved in vesicle-mediated transport . Yeast Bet3 is a core component of transport protein particle (TRAPP) complexes I-III. The TRAPPI complex recognises the coat (COPII) on ER-derived vesicles, wherea...

[ "GO:0048193", "GO:0030008" ]

[ "Golgi vesicle transport", "TRAPP complex" ]

[ "biological_process", "cellular_component" ]

2

[ "PIRSF", "PANTHER", "CDD" ]

[ "PIRSF018293", "PTHR13048", "cd14942" ]

[ "TRAPP_I_complex_Bet3", "", "TRAPPC3_bet3" ]

[ 4461, 5266, 5035 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-204005", "R-CEL-8876198", "R-DDI-204005", "R-DDI-8876198", "R-GGA-204005", "R-HSA-204005", "R-HSA-8876198", "R-MMU-204005", "R-MMU-8876198", "R-RNO-204005", "R-RNO-8876198", "R-SCE-204005", "R-SCE-8876198", "R-SPO-204005", "R-SPO-8876198" ]

[ "REACTOME:R-CEL-204005", "REACTOME:R-CEL-8876198", "REACTOME:R-DDI-204005", "REACTOME:R-DDI-8876198", "REACTOME:R-GGA-204005", "REACTOME:R-HSA-204005", "REACTOME:R-HSA-8876198", "REACTOME:R-MMU-204005", "REACTOME:R-MMU-8876198", "REACTOME:R-RNO-204005", "REACTOME:R-RNO-8876198", "REACTOME:R-SC...

15

[ "1sz7", "1wc8", "1wc9", "2c0j", "2cfh", "2j3r", "2j3t", "2j3w", "2pwn", "3cue", "3kxc", "6aq3", "7b6d", "7b6r", "7b6x", "7b70", "7e2c", "7e2d", "7e8s", "7e8t", "7e93", "7e94", "7ea3", "7kmt", "7u05", "7u06" ]

26

[ "PUB00056043", "PUB00075298", "PUB00075414", "PUB00080272" ]

[ "20375281", "23986483", "21525244", "22669257" ]

[ "Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy.", "TRAPPIII is responsible for vesicular transport from early endosomes to Golgi, facilitating Atg9 cycling in autophagy.", "C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking.", ...

[ 2010, 2013, 2011, 2012 ]

4

[ "IPR007194" ]

[]

1

0

1

[ "Eukaryota" ]

[ 5343 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 3, 1, 1, 1, 6, 4, 2, 2, 8, 1, 1, 19 ]

12

true

Family

Bet3 family

Bet3

3

IPR016722

16,722

DNA polymerase alpha, subunit B

DNA_pol_alpha_bsu

Family

5,008

false

This group represents a DNA polymerase alpha, subunit B, which is essential for DNA replication in higher eukaryotes as it initiates synthesis on both leading and lagging strand single-stranded DNA templates. It consists of a primase heterodimer that synthesises RNA primers, a DNA polymerase that extends them, and a fo...

[]

0

[ "PIRSF", "PANTHER" ]

[ "PIRSF018300", "PTHR23061" ]

[ "DNA_pol_alph_2", "" ]

[ 3665, 5008 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-CEL-113501", "R-CEL-68952", "R-CEL-68962", "R-CEL-69091", "R-CEL-69166", "R-CEL-69183", "R-DDI-113501", "R-DDI-68952", "R-DDI-68962", "R-DDI-69091", "R-DDI-69166", "R-DDI-69183", "R-DME-113501", "R-DME-68952", "R-DME-68962", "R-DME-69091", "R-DME-69166", "R-DME-69183", "R-HSA-...

[ "REACTOME:R-CEL-113501", "REACTOME:R-CEL-68952", "REACTOME:R-CEL-68962", "REACTOME:R-CEL-69091", "REACTOME:R-CEL-69166", "REACTOME:R-CEL-69183", "REACTOME:R-DDI-113501", "REACTOME:R-DDI-68952", "REACTOME:R-DDI-68962", "REACTOME:R-DDI-69091", "REACTOME:R-DDI-69166", "REACTOME:R-DDI-69183", "R...

55

[ "3flo", "4y97", "5exr", "7opl", "7u5c", "7uy8", "8b9a", "8b9b", "8b9c", "8b9d", "8d0b", "8d0k", "8d9d", "8foc", "8fod", "8foe", "8foh", "8foj", "8fok", "8g99", "8g9f", "8qj7", "8v5m", "8v5n", "8v5o", "8v6g", "8v6h", "8v6i", "8v6j", "8vy3", "9c8v" ]

31

[ "PUB00093651" ]

[ "20234039" ]

[ "Structure of a DNA polymerase alpha-primase domain that docks on the SV40 helicase and activates the viral primosome." ]

[ 2010 ]

1

[]

0

null

[ "Eukaryota", "bird metagenome" ]

[ 5007, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 6, 1, 2, 2, 8, 10, 1, 5, 6, 1, 1, 9 ]

12

true

Family

DNA polymerase alpha, subunit B

DNA_pol_alpha_bsu

4

IPR016723

16,723

Transcription regulator, ArsR, predicted

Tscrpt_reg_ArsR_prd

Family

167

false

This group represents a predicted transcriptional regulator, ArsR type.

[]

0

[ "PIRSF" ]

[ "PIRSF018357" ]

[ "Trans_reg_ArsR_prd" ]

[ 167 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota", "ecological metagenomes" ]

[ 161, 6 ]

2

[]

0

true

Family

Transcription regulator, ArsR, predicted

Tscrpt_reg_ArsR_prd

4

IPR016725

16,725

Ogawa serotype, WbeT

Ogawa_serotype_WbeT

Family

23

false

This group represents an Ogawa serotype protein WbeT.

[]

0

[ "PIRSF" ]

[ "PIRSF018432" ]

[ "Ogawa_serotype_WbeT" ]

[ 23 ]

1

[]

0

[]

0

[]

0

[ "IPR008890" ]

[]

1

0

1

[ "Vibrio cholerae" ]

[ 23 ]

1

[]

0

true

Family

Ogawa serotype, WbeT

Ogawa_serotype_WbeT

4

IPR016726

16,726

Repressor protein C1

Repressor_C1

Family

130

false

This entry represents repressor protein C1 found in P7-like bacteriophages. Repressor protein C1 is a sequence-specific DNA-binding protein required for the establishment and maintenance of lysogeny [ ]. The protein is 283 amino acids (32.5 kDa) and contains a helix-turn-helix DNA-binding motif (residues 30-49) and a d...

[ "GO:0003677" ]

[ "DNA binding" ]

[ "molecular_function" ]

1

[ "NCBIFAM", "PFAM", "PIRSF" ]

[ "NF041318", "PF27008", "PIRSF018461" ]

[ "phage_rep_C1", "Phage_P7_repressor_C1", "Phage_repressor_C1_" ]

[ 62, 130, 46 ]

3

[]

0

[]

0

[ "PUB00055991", "PUB00106328", "PUB00162232" ]

[ "2678004", "15550568", "2678003" ]

[ "The c1 repressor of bacteriophage P1 operator-repressor interaction of wild-type and mutant repressor proteins.", "DNA recombination with a heterospecific Cre homolog identified from comparison of the pac-c1 regions of P1-related phages.", "The c1 genes of P1 and P7." ]

[ 1989, 2004, 1989 ]

3

[]

0

null

[ "Gammaproteobacteria", "Punavirus", "feces metagenome" ]

[ 118, 11, 1 ]

3

[]

0

true

Family

Repressor protein C1

Repressor_C1

2

IPR016727

16,727

ATPase, V0 complex, subunit D

ATPase_V0-cplx_dsu

Family

6,036

false

Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel ...

[ "GO:0046961", "GO:1902600", "GO:0033179" ]

[ "proton-transporting ATPase activity, rotational mechanism", "proton transmembrane transport", "proton-transporting V-type ATPase, V0 domain" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PIRSF", "PANTHER" ]

[ "PIRSF018497", "PTHR11028" ]

[ "V-ATP_synth_D", "" ]

[ 4663, 6036 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1222556", "R-BTA-77387", "R-BTA-917977", "R-BTA-9639288", "R-BTA-983712", "R-DDI-1222556", "R-DDI-77387", "R-DDI-917977", "R-DDI-9639288", "R-DME-1222556", "R-DME-77387", "R-DME-917977", "R-DME-9639288", "R-DME-983712", "R-DRE-1222556", "R-DRE-77387", "R-DRE-917977", "R-DRE-...

[ "REACTOME:R-BTA-1222556", "REACTOME:R-BTA-77387", "REACTOME:R-BTA-917977", "REACTOME:R-BTA-9639288", "REACTOME:R-BTA-983712", "REACTOME:R-DDI-1222556", "REACTOME:R-DDI-77387", "REACTOME:R-DDI-917977", "REACTOME:R-DDI-9639288", "REACTOME:R-DME-1222556", "REACTOME:R-DME-77387", "REACTOME:R-DME-9...

52

[ "3j9t", "3j9u", "3j9v", "5tj5", "5vox", "5voy", "5voz", "6c6l", "6m0r", "6m0s", "6o7t", "6o7u", "6o7v", "6o7w", "6o7x", "6pe4", "6pe5", "6vq6", "6vq7", "6vq8", "6vqc", "6vqg", "6vqh", "6wlw", "6wm2", "6wm3", "6wm4", "6xbw", "6xby", "7fda", "7fdb", "7fdc"...

75

[ "PUB00009752", "PUB00020603", "PUB00020604", "PUB00020608", "PUB00020609", "PUB00020618", "PUB00020633", "PUB00068786", "PUB00068787", "PUB00068788", "PUB00068789" ]

[ "11309608", "15473999", "15078220", "15907459", "15629643", "15168615", "15800125", "20450191", "18937357", "1385979", "9741106" ]

[ "Resolution of distinct rotational substeps by submillisecond kinetic analysis of F1-ATPase.", "The evolution of A-, F-, and V-type ATP synthases and ATPases: reversals in function and changes in the H+/ATP coupling ratio.", "Mechanisms of ATPases--a multi-disciplinary approach.", "A new view of an old pore."...

[ 2001, 2004, 2004, 2005, 2005, 2004, 2005, 2010, 2008, 1992, 1998 ]

11

[ "IPR002843" ]

[]

1

0

1

[ "Eukaryota", "marine sediment metagenome" ]

[ 6035, 1 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 7, 1, 1, 3, 14, 4, 1, 1, 8, 1, 1, 7 ]

12

true

Family

ATPase, V0 complex, subunit D

ATPase_V0-cplx_dsu

6

IPR016728

16,728

Neuroblastoma suppressor of tumourigenicity 1

Neuroblast_suppress_tumour_1

Family

470

false

This group represents the neuroblastoma suppressor of tumorigenicity 1 protein, also known as zinc finger protein DAN. This protein is a possible candidate for a tumor suppressor of neuroblastoma and may play an important role in preventing cells from entering the final stage (G1/S) of the transformation process [ ].

[]

0

[ "PIRSF" ]

[ "PIRSF018557" ]

[ "DAN_sub" ]

[ 470 ]

1

[]

0

[]

0

[ "PUB00042934" ]

[ "8084583" ]

[ "Identification of human DAN gene, mapping to the putative neuroblastoma tumor suppressor locus." ]

[ 1994 ]

1

[]

0

null

[ "Euteleostomi" ]

[ 470 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 3 ]

4

true

Family

Neuroblastoma suppressor of tumourigenicity 1

Neuroblast_suppress_tumour_1

1

IPR016729

16,729

FAS-associated death domain protein

FADD

Family

1,668

false

This entry includes FAS-associated death domain (FADD) proteins from animals. This entry includes the Fas-associated death domain (FADD) protein. This protein is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors [ , , , ]. The resulting aggregate, called...

[]

0

[ "PANTHER" ]

[ "PTHR15077" ]

[ "" ]

[ 1668 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-140534", "R-BTA-2562578", "R-BTA-3371378", "R-BTA-5218900", "R-BTA-5357786", "R-BTA-5357905", "R-BTA-5675482", "R-BTA-69416", "R-BTA-75157", "R-HSA-140534", "R-HSA-2562578", "R-HSA-3371378", "R-HSA-5213460", "R-HSA-5218900", "R-HSA-5357786", "R-HSA-5357905", "R-HSA-5675482", ...

[ "REACTOME:R-BTA-140534", "REACTOME:R-BTA-2562578", "REACTOME:R-BTA-3371378", "REACTOME:R-BTA-5218900", "REACTOME:R-BTA-5357786", "REACTOME:R-BTA-5357905", "REACTOME:R-BTA-5675482", "REACTOME:R-BTA-69416", "REACTOME:R-BTA-75157", "REACTOME:R-HSA-140534", "REACTOME:R-HSA-2562578", "REACTOME:R-HS...

33

[ "1e3y", "1e41", "1fad", "1wxp", "2gf5", "3ezq", "3oq9", "6ac5", "6aci", "8ybx", "8yd7", "8yd8", "8yni", "9kv7", "9n94", "9ncq", "9u6e" ]

17

[ "PUB00004278", "PUB00005739", "PUB00033463", "PUB00042863", "PUB00042864", "PUB00051843", "PUB00056582", "PUB00153054", "PUB00153055" ]

[ "9582077", "7538907", "12702765", "11034606", "16127453", "19118384", "20935634", "23955153", "24025841" ]

[ "NMR structure and mutagenesis of the FADD (Mort1) death-effector domain.", "FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis.", "Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome s...

[ 1998, 1995, 2003, 2000, 2005, 2009, 2010, 2013, 2013 ]

9

[]

[ "IPR049634" ]

0

1

0

[ "Gammaproteobacteria", "Metazoa" ]

[ 2, 1666 ]

2

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 3, 2, 2 ]

4

true

Family

FAS-associated death domain protein

FADD

1

IPR016730

16,730

RNA-binding FAU-1

RNA-bd_FAU-1

Family

434

false

This entry represents the FAU-1 protein from archaea. In Pyrococcus furiosus, FAU-1 (P. furiosus AU-binding), is highly charged, heat-stable protein from that binds specifically to the AU-rich sequence in a loop region of RNA [ , ]. FAU-1 consists of two domains, N- and C-terminal, and from a structure determined in FA...

[ "GO:0003723" ]

[ "RNA binding" ]

[ "molecular_function" ]

1

[ "HAMAP", "PIRSF" ]

[ "MF_01910", "PIRSF018644" ]

[ "RNA_binding_AU_1", "RNA-binding_FAU-1" ]

[ 432, 400 ]

2

[ "EC" ]

[ "3.1.26.-" ]

[ "EC:3.1.26.-" ]

1

[ "8rza", "8rzf", "8wo8" ]

3

[ "PUB00035944", "PUB00091093", "PUB00156047", "PUB00156048" ]

[ "12614195", "28978920", "39445822", "38302756" ]

[ "Expression cloning and characterization of a novel gene that encodes the RNA-binding protein FAU-1 from Pyrococcus furiosus.", "An archaeal RNA binding protein, FAU-1, is a novel ribonuclease related to rRNA stability in Pyrococcus and Thermococcus.", "RNase W, a conserved ribonuclease family with a novel acti...

[ 2003, 2017, 2024, 2024 ]

4

[]

0

null

[ "Archaea" ]

[ 434 ]

1

[]

0

true

Family

RNA-binding FAU-1

RNA-bd_FAU-1

6

IPR016731

16,731

Uncharacterised conserved protein UCP018649

UCP018649

Family

7

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF018649" ]

[ "UCP018649" ]

[ 7 ]

1

[]

0

[]

0

[]

0

[ "IPR018333" ]

[]

1

0

1

[ "Thermococcaceae" ]

[ 7 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP018649

UCP018649

5

IPR016733

16,733

Uncharacterised conserved protein UCP018747

UCP018747

Family

231

false

This entry includes Uncharacterized protein MTH_863 and Uncharacterized protein MJ1453 from archaea. The structure of Uncharacterized protein MTH_863 has been solved .

[]

0

[ "PIRSF" ]

[ "PIRSF018747" ]

[ "UCP018747" ]

[ 231 ]

1

[]

0

[ "2ptf" ]

1

[]

0

[]

0

null

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 200, 23, 8 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP018747

UCP018747

1

IPR016735

16,735

Methanogenesis marker 12 protein

Methan_mark_12

Family

228

false

This group represents uncharacterised conserved proteins. They share distant sequence similarity with members of . The exact function is unknown, but likely is linked to methanogenesis or a process closely connected to it.

[]

0

[ "HAMAP", "PIRSF", "NCBIFAM" ]

[ "MF_01087", "PIRSF018783", "TIGR03281" ]

[ "UPF0285", "UCP018783", "methan_mark_12" ]

[ 224, 152, 228 ]

3

[ "GP" ]

[ "GenProp0722" ]

[ "GP:GenProp0722" ]

1

[]

0

[]

0

[]

0

null

[ "Methanobacteriota", "ecological metagenomes" ]

[ 223, 5 ]

2

[]

0

true

Family

Methanogenesis marker 12 protein

Methan_mark_12

7

IPR016736

16,736

MJ1481-like

Family

68

false

This family contains proteins conserved in archaea, including MJ1481 from Methanocaldococcus jannaschii, which has been reported to be SepCysE, a translation factor, essential for the methanococcal Cys biosynthesis. SepCysE forms a bridge between Sep-tRNA:Cys-tRNA synthase (SepCysS) and O-phosphoseryl-tRNA synthetase (...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09873", "PIRSF018814" ]

[ "SepCysE", "UCP018814" ]

[ 68, 20 ]

2

[]

0

[ "3wkr", "3wks", "5x6b", "5x6c" ]

4

[ "PUB00093676", "PUB00093677" ]

[ "25002468", "29142195" ]

[ "Ancient translation factor is essential for tRNA-dependent cysteine biosynthesis in methanogenic archaea.", "Structural basis for tRNA-dependent cysteine biosynthesis." ]

[ 2014, 2017 ]

2

[]

0

null

[ "Archaea", "bioreactor metagenome" ]

[ 67, 1 ]

2

[]

0

true

Family

MJ1481-like

1

IPR016737

16,737

Uncharacterised conserved protein UCP018868, archaea

UCP018868_archaea

Family

7

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF018868" ]

[ "UCP018868" ]

[ 7 ]

1

[]

0

[]

0

[]

0

[ "IPR060748" ]

[]

1

0

1

[ "Thermococcaceae" ]

[ 7 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP018868, archaea

UCP018868_archaea

5

IPR016738

16,738

DNA double-strand break repair nuclease NurA-like

NurA-like

Family

47

false

This entry represents NurA, an archaeal nuclease that exhibits both single-stranded endonuclease activity and 5'-3' exonuclease activity on single-stranded and double-stranded DNA from the hyperthermophilic archaeon Sulfolobus acidocaldarius [ ]. This entry also includes similar uncharacterised proteins.

[]

0

[ "PIRSF" ]

[ "PIRSF018871" ]

[ "UCP018871" ]

[ 47 ]

1

[]

0

[ "3tai", "3tal", "3taz" ]

3

[ "PUB00044410" ]

[ "12052775" ]

[ "NurA, a novel 5'-3' nuclease gene linked to rad50 and mre11 homologs of thermophilic Archaea." ]

[ 2002 ]

1

[]

0

null

[ "Methanobacteriota" ]

[ 47 ]

1

[]

0

true

Family

DNA double-strand break repair nuclease NurA-like

NurA-like

1

IPR016739

16,739

Uncharacterised conserved protein UCP018933

UCP018933

Family

7

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF018933" ]

[ "UCP018933" ]

[ 7 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Thermococcaceae" ]

[ 7 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP018933

UCP018933

7

IPR016740

16,740

Uncharacterised conserved protein UCP018938

UCP018938

Family

39

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27714", "PIRSF018938" ]

[ "UCP018938", "UCP018938" ]

[ 39, 7 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Thermococcaceae" ]

[ 39 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP018938

UCP018938

1

IPR016741

16,741

Mb0898c-like

Family

1,170

false

This entry includes Uncharacterized protein Mb0898c, Rv0874c, Rv0628c and related uncharacterised proteins in bacteria. They contain a FIST domain in their N and C-terminal represented by and .

[]

0

[ "PIRSF" ]

[ "PIRSF018953" ]

[ "UCP018953" ]

[ 1170 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 1096, 28, 46 ]

3

[]

0

true

Family

Mb0898c-like

5

IPR016742

16,742

tRNA methyltransferase, archaea

tRNA_m1G_mtfrase_arc

Family

129

false

This group represents a group of tRNA (guanine-N(1)-)-methyltransferases from archaeal, including TK0422 from Thermococcus kodakaraensis and Saci_1677 from Sulfolobus acidocaldarius. TK0422 catalyzes the S-adenosyl-L-methionine-dependent formation of either N(1)-methyladenine or N(1)-methylguanine at position 9 (m1A9 o...

[ "GO:0008175", "GO:0030488" ]

[ "tRNA methyltransferase activity", "tRNA methylation" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF018978" ]

[ "tRNA_m1G_mtfrase_arc_prd" ]

[ 129 ]

1

[]

0

[ "5a7t", "5a7y", "5a7z", "6ems" ]

4

[ "PUB00075405" ]

[ "20525789" ]

[ "New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA." ]

[ 2010 ]

1

[]

0

null

[ "Archaea", "Desulfurobacteriaceae" ]

[ 126, 3 ]

2

[]

0

true

Family

tRNA methyltransferase, archaea

tRNA_m1G_mtfrase_arc

8

IPR016743

16,743

Nuclear factor interleukin-3-regulated protein

NFIL3/E4BP4

Family

264

false

Nuclear factor interleukin-3-regulated protein (NFIL3, also known as E4BP4) was first identified as a transcriptional repressor capable of binding an activating transcription factor (ATF) DNA consensus sequence site in the adenovirus E4 promoter [ ]. Later, it was independently identified as a transactivator of the IL3...

[ "GO:0003700", "GO:0006366", "GO:0006955", "GO:0005634" ]

[ "DNA-binding transcription factor activity", "transcription by RNA polymerase II", "immune response", "nucleus" ]

[ "molecular_function", "biological_process", "biological_process", "cellular_component" ]

4

[ "PIRSF" ]

[ "PIRSF019029" ]

[ "bZIP_E4BP4" ]

[ 264 ]

1

[]

0

[]

0

[ "PUB00012641", "PUB00071171", "PUB00071172", "PUB00101954" ]

[ "1620116", "22075207", "7565758", "16310763" ]

[ "Transcriptional repression by a novel member of the bZIP family of transcription factors.", "E4BP4: an unexpected player in the immune response.", "Molecular cloning and characterization of NF-IL3A, a transcriptional activator of the human interleukin-3 promoter.", "The bZip proteins CES-2 and ATF-2 alter th...

[ 1992, 2012, 1995, 2006 ]

4

[ "IPR047229" ]

[]

1

0

1

[ "Euteleostomi" ]

[ 264 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 1, 2 ]

4

true

Family

Nuclear factor interleukin-3-regulated protein

NFIL3/E4BP4

4

IPR016744

16,744

Uncharacterised conserved protein UCP019072

UCP019072

Family

7

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF019072" ]

[ "UCP019072" ]

[ 7 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Thermococcaceae" ]

[ 7 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP019072

UCP019072

4

IPR016745

16,745

Archaeal GINS complex, Gins51 subunit

Gins51

Family

11

false

This protein family includes the GINS subunit Gins51 from Thermococcus kodakarensis and similar proteins from archaea. Archaeal GINS is a α2β2 type tetramer that plays a key role to move from initiation to elongation of the DNA replication. Gin51 is organised into a larger α-helical domain at the N-terminal and a small...

[]

0

[ "PIRSF" ]

[ "PIRSF019075" ]

[ "UCP019075" ]

[ 11 ]

1

[]

0

[ "3anw" ]

1

[ "PUB00088351" ]

[ "21527023" ]

[ "Architectures of archaeal GINS complexes, essential DNA replication initiation factors." ]

[ 2011 ]

1

[]

0

null

[ "Archaea" ]

[ 11 ]

1

[]

0

true

Family

Archaeal GINS complex, Gins51 subunit

Gins51

2

IPR016747

16,747

Phosphotransbutyrylase

Family

2,271

false

This entry represents a family of phosphotransbutyrylases that contain a VanZ domain.

[]

0

[ "PIRSF" ]

[ "PIRSF019083" ]

[ "UCP019083_VanZ" ]

[ 2271 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanosarcinaceae", "unclassified sequences" ]

[ 2257, 6, 8 ]

3

[]

0

true

Family

Phosphotransbutyrylase

6

IPR016748

16,748

Transcription regulator, CopG/Arc/MetJ DNA-binding domain-containing, predicted

Tscrpt_reg_CopG_prd

Family

17

false

This group represents a predicted transcriptional regulator with CopG/Arc/MetJ DNA-binding domain.

[]

0

[ "PIRSF" ]

[ "PIRSF019108" ]

[ "Txn_reg_CopG_prd" ]

[ 17 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota" ]

[ 17 ]

1

[]

0

true

Family

Transcription regulator, CopG/Arc/MetJ DNA-binding domain-containing, predicted

Tscrpt_reg_CopG_prd

8

IPR016750

16,750

Acetophenone carboxylase beta subunit/Acetone carboxylase gamma subunit

Aceto_COase_bsu/gsu

Family

858

false

This entry represents the beta subunit of acetophenone carboxylase and the gamma subunit of acetone carboxylase. Acetophenone carboxylase catalyses the carboxylation of acetophenone to form 3-oxo-3-phenylpropanoate (benzoylacetate) in the anaerobic catabolism of ethylbenzene [ ]. Acetone carboxylase catalyses the carbo...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF08882", "PIRSF019217" ]

[ "Acetone_carb_G", "Acetone_carboxlyase_gsu" ]

[ 858, 489 ]

2

[]

0

[ "5l9w", "5m45", "5svb", "5svc" ]

4

[ "PUB00062149", "PUB00062150" ]

[ "20047908", "9237998" ]

[ "ATP-dependent carboxylation of acetophenone by a novel type of carboxylase.", "Purification and characterization of acetone carboxylase from Xanthobacter strain Py2." ]

[ 2010, 1997 ]

2

[]

[ "IPR050001" ]

0

1

0

[ "Archaea", "Austropuccinia psidii MF-1", "Bacteria", "unclassified sequences" ]

[ 29, 1, 798, 30 ]

4

[]

0

true

Family

Acetophenone carboxylase beta subunit/Acetone carboxylase gamma subunit

Aceto_COase_bsu/gsu

1

IPR016751

16,751

Uncharacterised conserved protein UCP019236

UCP019236

Family

8

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF019236" ]

[ "UCP019236" ]

[ 8 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea" ]

[ 8 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP019236

UCP019236

9

IPR016752

16,752

Uncharacterised conserved protein UCP019240, SpoVT/AbrB-related

UCP019240_SpoVT/AbrB-related

Family

30

false

This entry represents a small family of archaeal proteins, including SpoVT-AbrB domain-containing protein from Pyrococcus horikoshii (PHS018, ), which consists of six-stranded Greek-key barrel fold and two α-helices, with a very similar overall appearance to the double-psi and swapped-hairpin β-barrel [ ]. Members of t...

[]

0

[ "PIRSF" ]

[ "PIRSF019240" ]

[ "UCP019240_SpoVT/AbrB-related" ]

[ 30 ]

1

[]

0

[ "2glw" ]

1

[ "PUB00041103" ]

[ "17027498" ]

[ "Common evolutionary origin of swapped-hairpin and double-psi beta barrels." ]

[ 2006 ]

1

[]

0

null

[ "Thermococcaceae" ]

[ 30 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP019240, SpoVT/AbrB-related

UCP019240_SpoVT/AbrB-related

3

IPR016753

16,753

Phage portal protein PBSX family, Firmicutes

PBSX_Firmicutes

Family

263

false

This entry represents the phage-like element PBSX protein from Firmicutes. PBSX protein forms a hole, or portal, that enables DNA passage during packaging and ejection. It also forms the junction between the phage head (capsid) and the tail proteins. It functions as a dodecamer of a single polypeptide of average molecu...

[]

0

[ "PIRSF" ]

[ "PIRSF019260" ]

[ "PBSX_XkdE_prd" ]

[ 263 ]

1

[]

0

[]

0

[]

0

[ "IPR006430" ]

[]

1

0

1

[ "Bacteria", "Caudoviricetes", "Methanobacteriota" ]

[ 236, 22, 5 ]

3

[]

0

true

Family

Phage portal protein PBSX family, Firmicutes

PBSX_Firmicutes

8

IPR016754

16,754

Connectase MJ0548-like

MJ0548-like

Family

144

false

This entry represents Connectase MJ0548 from Methanocaldococcus jannaschii and similar archaeal sequences. MJ0548 is a distant, monomeric proteasome homologue which connects proteins in a sequence-specific manner. It forms a hydrolysis-resistant amide intermediate between the Thr-1 amino group and the substrate carbony...

[]

0

[ "PIRSF" ]

[ "PIRSF019262" ]

[ "UCP019262" ]

[ 144 ]

1

[]

0

[ "6zvz", "6zw0", "8jtu", "8wkd" ]

4

[ "PUB00158988" ]

[ "33688044" ]

[ "Archaeal Connectase is a specific and efficient protein ligase related to proteasome β subunits." ]

[ 2021 ]

1

[]

0

null

[ "Methanobacteriota", "ecological metagenomes" ]

[ 142, 2 ]

2

[]

0

true

Family

Connectase MJ0548-like

MJ0548-like

4

IPR016755

16,755

Uncharacterised conserved protein UCP019302

UCP019302

Family

1,181

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10084", "PIRSF019302" ]

[ "DUF2322", "UCP019302" ]

[ 1181, 1042 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 1125, 43, 13 ]

3

[]

0

true

Family

Uncharacterised conserved protein UCP019302

UCP019302

8

IPR016756

16,756

Metal-dependent hydrolase, membrane-bound predicted

Metal-dep_Ohase_Mem-prd

Family

7

false

This group represents a small group of predicted membrane-bound metal-dependent hydrolases found in Thermococci.

[]

0

[ "PIRSF" ]

[ "PIRSF019311" ]

[ "Mb_md_hydr_PF0129_prd" ]

[ 7 ]

1

[]

0

[]

0

[]

0

[ "IPR007404" ]

[]

1

0

1

[ "Thermococcaceae" ]

[ 7 ]

1

[]

0

true

Family

Metal-dependent hydrolase, membrane-bound predicted

Metal-dep_Ohase_Mem-prd

4

IPR016757

16,757

Uncharacterised conserved protein UCP019322

UCP019322

Family

360

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF019322" ]

[ "UCP019322" ]

[ 360 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota", "bioreactor metagenome" ]

[ 359, 1 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP019322

UCP019322

3

IPR016758

16,758

Glucose-6-phosphate isomerase, archaea/bacteria

G6P_isomerase_archaea/bacteria

Family

166

false

This entry represents a group of glucose-6-phosphate isomerases from archaea and bacteria [ ].

[ "GO:0004347", "GO:0005506" ]

[ "glucose-6-phosphate isomerase activity", "iron ion binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "HAMAP", "PIRSF" ]

[ "MF_01410", "PIRSF019325" ]

[ "G6P_isomerase_arch", "Glucose-6-phosphate_isomerase" ]

[ 52, 166 ]

2

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "5.3.1.9", "PWY-3801", "PWY-5054", "PWY-5384", "PWY-5514", "PWY-5659", "PWY-6142", "PWY-621", "PWY-622", "PWY-6981", "PWY-6992", "PWY-7238", "PWY-7347", "PWY-7385", "PWY-8013" ]

[ "EC:5.3.1.9", "METACYC:PWY-3801", "METACYC:PWY-5054", "METACYC:PWY-5384", "METACYC:PWY-5514", "METACYC:PWY-5659", "METACYC:PWY-6142", "METACYC:PWY-621", "METACYC:PWY-622", "METACYC:PWY-6981", "METACYC:PWY-6992", "METACYC:PWY-7238", "METACYC:PWY-7347", "METACYC:PWY-7385", "METACYC:PWY-801...

15

[ "1j3p", "1j3q", "1j3r", "1qxj", "1qxr", "1qy4", "1x7n", "1x82", "1x8e", "2gc0", "2gc1", "2gc2", "2gc3", "3sxw", "4lta", "4luk", "4lul", "4lum" ]

18

[ "PUB00046212" ]

[ "12560104" ]

[ "Characterization of the cupin-type phosphoglucose isomerase from the hyperthermophilic archaeon Thermococcus litoralis." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Thermococcaceae" ]

[ 121, 45 ]

2

[]

0

true

Family

Glucose-6-phosphate isomerase, archaea/bacteria

G6P_isomerase_archaea/bacteria

7

IPR016759

16,759

HTH-type transcriptional repressor RghR

RghR

Family

62

false

RghR represses the expression of yvaM and both rapG and rapH. It binds directly to the promoter regions of yvaM, rapG and rapH [ ].

[ "GO:0003677", "GO:0006355" ]

[ "DNA binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF019364" ]

[ "RapGH_repressor" ]

[ 62 ]

1

[]

0

[]

0

[ "PUB00073679" ]

[ "16553878" ]

[ "Bacillus subtilis RghR (YvaN) represses rapG and rapH, which encode inhibitors of expression of the srfA operon." ]

[ 2006 ]

1

[]

0

null

[ "Bacillus" ]

[ 62 ]

1

[]

0

true

Family

HTH-type transcriptional repressor RghR

RghR

5

IPR016760

16,760

Radical S-adenosyl methionine enzyme HcgG-like

HcgG-like

Family

89

false

This protein family includes HcgA from Methanococcus maripaludis (MMP0125, ) and similar archaeal proteins. HcgG is a radical S-adenosyl methionine enzyme involved in the biosynthesis of the iron-guanylylpyridinol (FeGP) cofactor [ ]. Proteins annotated as HmdC, whose gene regularly occurs in the context of genes for H...

[]

0

[ "PFAM", "PIRSF", "NCBIFAM" ]

[ "PF10113", "PIRSF019375", "TIGR03958" ]

[ "Fibrillarin_2", "UCP019375", "monoFe_hyd_HmdC" ]

[ 89, 60, 89 ]

3

[ "GP" ]

[ "GenProp0915" ]

[ "GP:GenProp0915" ]

1

[]

0

[ "PUB00055023", "PUB00098596", "PUB00158981" ]

[ "19897660", "25882909", "36264001" ]

[ "Identification and characterization of a novel member of the radical AdoMet enzyme superfamily and implications for the biosynthesis of the Hmd hydrogenase active site cofactor.", "Protein-pyridinol thioester precursor for biosynthesis of the organometallic acyl-iron ligand in [Fe]-hydrogenase cofactor.", "The...

[ 2010, 2015, 2022 ]

3

[]

0

null

[ "Desulfurobacterium", "Methanobacteriota", "bioreactor metagenome" ]

[ 4, 84, 1 ]

3

[]

0

true

Family

Radical S-adenosyl methionine enzyme HcgG-like

HcgG-like

8

IPR016761

16,761

Uncharacterised conserved protein UCP019454, CBS

UCP019454_CBS

Family

21

false

This group represents an uncharacterised protein with two CBS domains.

[]

0

[ "PIRSF" ]

[ "PIRSF019454" ]

[ "UCP019454_CBS_PAB0389" ]

[ 21 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Methanobacteriota" ]

[ 21 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP019454, CBS

UCP019454_CBS

1

IPR016762

16,762

Methanogenesis marker 17 protein

Methan_mark_17

Family

261

false

There is currently no experimental data for members of this group or their homologues. Their function is unknown but they are likely to be linked to methanogenesis or a process closely connected to it [ ].

[]

0

[ "PFAM", "PIRSF", "NCBIFAM" ]

[ "PF09886", "PIRSF019464", "TIGR03291" ]

[ "DUF2113", "UCP019464", "methan_mark_17" ]

[ 261, 222, 258 ]

3

[ "GP" ]

[ "GenProp0722" ]

[ "GP:GenProp0722" ]

1

[ "8s7v", "8s7x", "9h1l" ]

3

[ "PUB00060475" ]

[ "22070167" ]

[ "ProPhylo: partial phylogenetic profiling to guide protein family construction and assignment of biological process." ]

[ 2011 ]

1

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 255, 6 ]

2

[]

0

true

Family

Methanogenesis marker 17 protein

Methan_mark_17

1

IPR016763

16,763

Vesicle-associated membrane-protein-associated protein

VAP

Family

13,254

false

This entry represents a family of vesicle-associated membrane-protein-associated proteins (VAPs) and plant VAP homologs (PVAPs) [ ]. VAPs (VAPA and VAPB in humans, VAPA, VAPB and VAPC in other mammals [ ]) are endoplasmic reticulum (ER) proteins that play roles in vesicle trafficking, neurotransmitter release, microtub...

[ "GO:0005789" ]

[ "endoplasmic reticulum membrane" ]

[ "cellular_component" ]

1

[ "PIRSF", "PANTHER" ]

[ "PIRSF019693", "PTHR10809" ]

[ "VAMP-associated", "" ]

[ 7694, 13254 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1660661", "R-BTA-6798695", "R-BTA-8980692", "R-BTA-9013106", "R-BTA-9013404", "R-BTA-9013405", "R-BTA-9013408", "R-BTA-9609523", "R-HSA-1660661", "R-HSA-6798695", "R-HSA-8980692", "R-HSA-9013106", "R-HSA-9013404", "R-HSA-9013405", "R-HSA-9013408", "R-HSA-9609523", "R-MMU-67986...

[ "REACTOME:R-BTA-1660661", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-8980692", "REACTOME:R-BTA-9013106", "REACTOME:R-BTA-9013404", "REACTOME:R-BTA-9013405", "REACTOME:R-BTA-9013408", "REACTOME:R-BTA-9609523", "REACTOME:R-HSA-1660661", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-8980692", "REACTOM...

40

[ "1z9l", "1z9o", "2cri", "2mdk", "2rr3", "3ikk", "6lp4", "6tqr", "7x14", "8hqu", "8hs7", "9jui" ]

12

[ "PUB00018205", "PUB00071993", "PUB00071999", "PUB00072001" ]

[ "9920726", "18468439", "19207211", "15668246" ]

[ "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins.", "The VAP protein family: from cellular functions to motor neuron disease.", "The targeting of the oxysterol-binding protein ORP3a to the endoplasmic reticulum relies on...

[ 1999, 2008, 2009, 2005 ]

4

[]

0

null

[ "Eukaryota" ]

[ 13254 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 47, 2, 6, 7, 7, 8, 1, 42, 11, 2, 2, 94 ]

12

true

Family

Vesicle-associated membrane-protein-associated protein

VAP

4

IPR016764

16,764

Methyltransferase Mtx subunit X

MeTrfase_MtxX_xsu

Family

234

false

This group represents a methyltransferase Mtx subunit X, also referred to as methanogenesis marker protein Mmp4/MtxX [ ]. The exact function is unknown, but likely is linked to methanogenesis or a process closely linked to it. Some members have been suggested to be a methyltransferase, based on the proximity of its gen...

[ "GO:0008168" ]

[ "methyltransferase activity" ]

[ "molecular_function" ]

1

[ "PIRSF", "NCBIFAM" ]

[ "PIRSF019709", "TIGR03270" ]

[ "Methyltransf_MtxX", "methan_mark_4" ]

[ 121, 233 ]

2

[ "EC", "GP", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.1.1.-", "GenProp0722", "PWY-1061", "PWY-2083", "PWY-3542", "PWY-4021", "PWY-4161", "PWY-4202", "PWY-5059", "PWY-5105", "PWY-5301", "PWY-5305", "PWY-5479", "PWY-5665", "PWY-5729", "PWY-5748", "PWY-5765", "PWY-5773", "PWY-5846", "PWY-5883", "PWY-5975", "PWY-5987", "PWY-6...

[ "EC:2.1.1.-", "GP:GenProp0722", "METACYC:PWY-1061", "METACYC:PWY-2083", "METACYC:PWY-3542", "METACYC:PWY-4021", "METACYC:PWY-4161", "METACYC:PWY-4202", "METACYC:PWY-5059", "METACYC:PWY-5105", "METACYC:PWY-5301", "METACYC:PWY-5305", "METACYC:PWY-5479", "METACYC:PWY-5665", "METACYC:PWY-572...

147

[]

0

[ "PUB00106733" ]

[ "18391432" ]

[ "Preliminary structural studies on the MtxX protein from Methanococcus jannaschii." ]

[ 2008 ]

1

[]

0

null

[ "Archaea", "ecological metagenomes" ]

[ 224, 10 ]

2

[]

0

true

Family

Methyltransferase Mtx subunit X

MeTrfase_MtxX_xsu

6

IPR016765

16,765

Metal-dependent membrane protease, predicted

M_metal-dep_Prtase_arc_prd

Family

7

false

This entry represents a predicted metal-dependent membrane protease found in archaea.

[]

0

[ "PIRSF" ]

[ "PIRSF019711" ]

[ "Memb_prtease_arc_prd" ]

[ 7 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Thermococcaceae" ]

[ 7 ]

1

[]

0

true

Family

Metal-dependent membrane protease, predicted

M_metal-dep_Prtase_arc_prd

4

IPR016766

16,766

Trichothecene biosynthesis transcription regulator TRI6

Tscrpt_reg_Tri6

Family

42

false

Tri6 is part of the core trichothecene biosynthesis cluster [ , , , ]. It is a zinc finger DNA-binding protein that functions as a pathway-specific transcription factor and positively regulates the other Tri genes [ ].

[ "GO:0003676", "GO:0006355" ]

[ "nucleic acid binding", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "PIRSF" ]

[ "PIRSF019847" ]

[ "Trans_reg_Tri6" ]

[ 42 ]

1

[]

0

[]

0

[ "PUB00017111", "PUB00087313", "PUB00087314", "PUB00087315", "PUB00087316" ]

[ "11352533", "7646028", "16347944", "12732543", "10361036" ]

[ "A genetic and biochemical approach to study trichothecene diversity in Fusarium sporotrichioides and Fusarium graminearum.", "Tri6 encodes an unusual zinc finger protein involved in regulation of trichothecene biosynthesis in Fusarium sporotrichioides.", "Regulation of Trichodiene Synthase in Fusarium sporotri...

[ 2001, 1995, 1989, 2003, 1999 ]

5

[]

0

null

[ "Fusarium sambucinum species complex" ]

[ 42 ]

1

[]

0

true

Family

Trichothecene biosynthesis transcription regulator TRI6

Tscrpt_reg_Tri6

7

IPR016767

16,767

Uncharacterised conserved protein UCP019853

UCP019853

Family

305

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members of this entry are mainly found in proteobacteria. The family is composed of two β-barrel domains.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27718", "PIRSF019853" ]

[ "UCP019853", "UCP019853" ]

[ 305, 160 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Methanotorris formicicus Mc-S-70" ]

[ 304, 1 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP019853

UCP019853

8

IPR016768

16,768

Uncharacterised conserved protein UCP019883, membrane

UCP019883

Family

1,399

false

There is currently no experimental data for members of this group or their homologues. However, these proteins are predicted to contain transmembrane segments.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10993", "PIRSF019883" ]

[ "DUF2818", "UCP019883" ]

[ 1399, 1259 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "metagenomes" ]

[ 1384, 15 ]

2

[]

0

true

Family

Uncharacterised conserved protein UCP019883, membrane

UCP019883

9

IPR016769

16,769

Bacteriophage SP01, Orf1

Phage_SP01_Orf1

Family

1,130

false

This entry is represented by Bacteriophage SP01, Orf1. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches. There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are ma...

[]

0

[ "PIRSF" ]

[ "PIRSF020079" ]

[ "UCP020079" ]

[ 1130 ]

1

[]

0

[ "2obb" ]

1

[]

0

[]

0

null

[ "Bacteria", "Methanocella paludicola (strain DSM 17711 / JCM 13418 / NBRC 101707 / SANAE)", "Viruses", "metagenomes" ]

[ 1047, 1, 61, 21 ]

4

[]

0

true

Family

Bacteriophage SP01, Orf1

Phage_SP01_Orf1

2

IPR016770

16,770

Nonstructural, NS2

Non-structural_NS2

Family

32

false

This group represents a nonstructural protein NS2.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF27719", "PIRSF020196" ]

[ "Parvo_NS2", "Nonstructural_NS2" ]

[ 32, 8 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Parvoviridae", "Trichonephila clavipes" ]

[ 31, 1 ]

2

[]

0

true

Family

Nonstructural, NS2

Non-structural_NS2

9

IPR016772

16,772

Uncharacterised conserved protein UCP020408

UCP020408

Family

3,631

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10087", "PIRSF020408" ]

[ "DUF2325", "UCP020408" ]

[ 3631, 863 ]

2

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "metagenomes" ]

[ 3587, 2, 14, 28 ]

4

[]

0

true

Family

Uncharacterised conserved protein UCP020408

UCP020408

9

IPR016773

16,773

Ferric uptake regulator, CjrA, predicted

Fe3_uptake_reg_CjrA_prd

Family

1,764

false

This group represents a predicted ferric uptake regulator, CjrA type.

[]

0

[ "PIRSF" ]

[ "PIRSF020419" ]

[ "Fe_uptake_reg_CjrA_prd" ]

[ 1764 ]

1

[]

0

[ "2g5g" ]

1

[]

0

[]

0

null

[ "Bacteria", "unclassified sequences" ]

[ 1748, 16 ]

2

[]

0

true

Family

Ferric uptake regulator, CjrA, predicted

Fe3_uptake_reg_CjrA_prd

7

IPR016775

16,775

Nodulation, NolB

Nodulation_NolB

Family

116

false

This group represents a nodulation protein, NolB type [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF17398", "PIRSF020514" ]

[ "NolB", "Nodulation_NolB" ]

[ 116, 17 ]

2

[]

0

[]

0

[ "PUB00012767" ]

[ "8412662" ]

[ "Molecular cloning and characterization of a sym plasmid locus that regulates cultivar-specific nodulation of soybean by Rhizobium fredii USDA257." ]

[ 1993 ]

1

[]

0

null

[ "Hyphomicrobiales" ]

[ 116 ]

1

[]

0

true

Family

Nodulation, NolB

Nodulation_NolB

2

IPR016777

16,777

Uncharacterised conserved protein UCP020772

UCP020772

Family

28

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF020772" ]

[ "UCP020772" ]

[ 28 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pasteurellaceae" ]

[ 28 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP020772

UCP020772

2

IPR016778

16,778

Competence protein ComB

Competence_ComB

Family

163

false

Competence is the ability of a cell to take up exogenous DNA from its environment, resulting in transformation. It is widespread among bacteria and is probably an important mechanism for the horizontal transfer of genes. DNA usually becomes available by the death and lysis of other cells. Competent bacteria use compone...

[]

0

[ "PIRSF" ]

[ "PIRSF020785" ]

[ "Competence_ComB" ]

[ 163 ]

1

[]

0

[]

0

[ "PUB00052316" ]

[ "8901420" ]

[ "Who's competent and when: regulation of natural genetic competence in bacteria." ]

[ 1996 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 163 ]

1

[]

0

true

Family

Competence protein ComB

Competence_ComB

1

IPR016779

16,779

Radical SAM enzyme, MSMEG0568

rSAM_MSMEG0568

Family

1,447

false

Members of this protein family are radical SAM proteins related to MSMEG_0568 from Mycobacterium smegmatis. Members occur within 8-gene operons in species as diverse as M. smegmatis, Rhizobium leguminosarum, Synechococcus elongatus, and Sorangium cellulosum. The function of the operon is unknown, but similarity of MSME...

[]

0

[ "PIRSF", "SFLD", "NCBIFAM" ]

[ "PIRSF020870", "SFLDG01107", "TIGR04043" ]

[ "Radical_SAM_bac_prd", "Uncharacterised_Radical_SAM_Su", "rSAM_MSMEG_0568" ]

[ 1130, 1447, 1431 ]

3

[ "GP" ]

[ "GenProp0939" ]

[ "GP:GenProp0939" ]

1

[]

0

[]

0

[ "IPR034405" ]

[]

1

0

1

[ "Archaea", "Bacteria", "ecological metagenomes" ]

[ 17, 1413, 17 ]

3

[]

0

true

Family

Radical SAM enzyme, MSMEG0568

rSAM_MSMEG0568

8

IPR016780

16,780

Uncharacterised conserved protein UCP020893, cyanophyceae

UCP020893_cyanophy

Family

177

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF020893" ]

[ "UCP020893" ]

[ 177 ]

1

[]

0

[]

0

[]

0

[ "IPR060751" ]

[]

1

0

1

[ "Cyanophyceae" ]

[ 177 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP020893, cyanophyceae

UCP020893_cyanophy

6

IPR016781

16,781

Anti-sigma regulatory factor, PmgA, predicted

Anti-sigma_regulat_PmgA_prd

Family

339

false

This group represents a predicted anti-sigma regulatory factor, PmgA type.

[]

0

[ "PIRSF" ]

[ "PIRSF020906" ]

[ "Anti_s_fact_PmgA_prd" ]

[ 339 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Cyanobacteriota" ]

[ 339 ]

1

[]

0

true

Family

Anti-sigma regulatory factor, PmgA, predicted

Anti-sigma_regulat_PmgA_prd

9

IPR016782

16,782

Uncharacterised conserved protein UCP022271

UCP022271

Family

4

false

There is currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function. Members are mainly found in clostridia.

[]

0

[ "PIRSF" ]

[ "PIRSF021171" ]

[ "UCP022271" ]

[ 4 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 4 ]

1

[]

0

true

Family

Uncharacterised conserved protein UCP022271

UCP022271

8

IPR016783

16,783

Biofilm formation YmcA

Biofilm_formation_YmcA

Family

1,769

false

Wild strains of Bacillus subtilis are capable of forming architecturally complex multicellular communities of cells known as biofilms. They display a high degree of spatiotemporal organisation [ ]. Exopolysaccharides may be responsible for binding chains of cells together in bundles [ ]. The six genes that are involved...

[]

0

[ "PIRSF" ]

[ "PIRSF021287" ]

[ "Biofilm_formation_YmcA" ]

[ 1769 ]

1

[]

0

[ "2pih", "6prh", "6prk" ]

3

[ "PUB00043614", "PUB00043615" ]

[ "15175311", "15661000" ]

[ "Genes involved in formation of structured multicellular communities by Bacillus subtilis.", "A master regulator for biofilm formation by Bacillus subtilis." ]

[ 2004, 2005 ]

2

[ "IPR010368" ]

[]

1

0

1

[ "Bacillati", "Phytophthora cactorum", "metagenomes" ]

[ 1766, 1, 2 ]

3

[]

0

true

Family

Biofilm formation YmcA

Biofilm_formation_YmcA

3

IPR016784

16,784

Uncharacterised protein UCP021288 with ACT domain

UCP021288_ACT

Family

1,521

false

This group represents an uncharacterised protein with an N-terminal ACT domain.

[]

0

[ "PIRSF" ]

[ "PIRSF021288" ]

[ "UCP021288_ACT" ]

[ 1521 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillota", "Phytophthora kernoviae 00238/432" ]

[ 1520, 1 ]

2

[]

0

true

Family

Uncharacterised protein UCP021288 with ACT domain

UCP021288_ACT

6

IPR016785

16,785

Competence protein ComGD

ComGD

Family

2,339

false

This entry represents Competence protein ComGD (also known as ComG operon protein 4) from Streptococcus pneumoniae, ComGD from Bacillus subtilis and similar proteins mainly found in Bacilli. Competence protein ComGD from Streptococcus pneumoniae is required for formation of the type IV-like pilus (T4P) that plays a rol...

[ "GO:0030420" ]

[ "establishment of competence for transformation" ]

[ "biological_process" ]

1

[ "NCBIFAM", "PIRSF" ]

[ "NF040982", "PIRSF021292" ]

[ "ComGD", "Competence_ComGD" ]

[ 1957, 1623 ]

2

[]

0

[]

0

[ "PUB00045992", "PUB00045993", "PUB00067657", "PUB00106112" ]

[ "9422590", "9723928", "2507524", "35004361" ]

[ "All seven comG open reading frames are required for DNA binding during transformation of competent Bacillus subtilis.", "Cell surface localization and processing of the ComG proteins, required for DNA binding during transformation of Bacillus subtilis.", "Nucleotide sequence and genetic organization of the Bac...

[ 1998, 1998, 1989, 2021 ]

4

[]

0

null

[ "Bacteria", "Siphoviridae sp. ctfM019", "ecological metagenomes" ]

[ 2334, 1, 4 ]

3

[]

0

true

Family

Competence protein ComGD

ComGD

8