interpro_id string | interpro_numeric_id int64 | name string | short_name string | entry_type string | protein_count int64 | is_llm bool | is_llm_reviewed bool | abstract string | go_ids list | go_terms list | go_categories list | go_count int64 | member_databases list | member_accessions list | member_names list | member_protein_counts list | member_count int64 | external_databases list | external_accessions list | external_xrefs list | external_xref_count int64 | pdb_ids list | structure_count int64 | publication_ids list | pubmed_ids list | publication_titles list | publication_years list | publication_count int64 | parent_ids list | child_ids list | parent_count int64 | child_count int64 | tree_depth float64 | taxonomy_names list | taxonomy_protein_counts list | taxonomy_count int64 | key_species_names list | key_species_protein_counts list | key_species_count int64 | in_entry_list bool | entry_list_type string | entry_list_name string | names_dat_name string | short_names_dat_name string | split_bucket int64 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IPR018262 | 18,262 | Large ribosomal subunit protein eL27, conserved site | Ribosomal_eL27_CS | Conserved_site | 3,526 | false | false | Large ribosomal subunit protein eL27 is found in fungi, plants, algae and vertebrates [ , ]. The family has a specific signature at the C terminus. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tRNA binding. This l... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS01107"
] | [
"RIBOSOMAL_L27E"
] | [
3526
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-72689",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-72689",
"R-CEL-72706",
"R-CEL-975956",
"R-CEL-975957",
"R-DDI-156827",
"R-DDI-1799339",
"R-DDI-72689",
"R-DDI-72706",
"R-DDI-97595... | [
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-1799339",
"REACTOME:R-CEL-72689",
"REACTOME:R-CEL-72706",
"REACTOME:R-CEL-9759... | 75 | [
"3j6x",
"3j6y",
"3j77",
"3j78",
"3j7o",
"3j7p",
"3j7q",
"3j7r",
"3j92",
"3jag",
"3jah",
"3jai",
"3jaj",
"3jan",
"3jct",
"4d5y",
"4d67",
"4u3m",
"4u3n",
"4u3u",
"4u4n",
"4u4o",
"4u4q",
"4u4r",
"4u4u",
"4u4y",
"4u4z",
"4u50",
"4u51",
"4u52",
"4u53",
"4u55"... | 492 | [
"PUB00000666",
"PUB00004579",
"PUB00007068",
"PUB00007069",
"PUB00007070"
] | [
"8148381",
"8058833",
"11297922",
"11290319",
"11114498"
] | [
"Cloning and nucleotide sequence of a full length cDNA encoding ribosomal protein L27 from human fetal kidney.",
"Nucleotide sequence of a cDNA clone for a 60S ribosomal protein L27 gene from potato (Solanum tuberosum L.).",
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The ... | [
1994,
1994,
2001,
2001,
2000
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Halopseudomonas pelagia"
] | [
3525,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
1,
2,
1,
4,
4,
1,
4,
4,
2,
2,
9
] | 12 | true | Conserved_site | Large ribosomal subunit protein eL27, conserved site | Large ribosomal subunit protein eL27, conserved site | Ribosomal_eL27_CS | 3 |
IPR018264 | 18,264 | Large ribosomal subunit protein bL33, conserved site | Ribosomal_bL33_CS | Conserved_site | 33,167 | false | false | Ribosomal protein bL33 is one of the proteins from the large ribosomal subunit. In Escherichia coli, bL33 has been shown to be on the surface of 50S subunit. This entry represents a conserved site located in the central section of these proteins [ , ]: Eubacterial bL33. Algal and plant chloroplast bL33c. Cyanelle bL33.... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS00582"
] | [
"RIBOSOMAL_L33"
] | [
33167
] | 1 | [] | [] | [] | 0 | [
"1nkw",
"1nwx",
"1nwy",
"1sm1",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1xbp",
"2j28",
"2rdo",
"2zjp",
"2zjq",
"2zjr",
"3bbx",
"3cf5",
"3dll",
"3j5l",
"3j5s",
"3j7z",
"3j9w",
"3j9y",
"3j9z",
"3ja1",
"3jbu",
"3jbv",
"3jcd",
"3jce",
"3jcj",
"3jcn",
"3pio"... | 1,063 | [
"PUB00000695",
"PUB00001843"
] | [
"1742360",
"8112583"
] | [
"Characterization and primary structure of proteins L28, L33 and L34 from Bacillus stearothermophilus ribosomes.",
"Identification of genes encoding ribosomal protein L33 from Bacillus licheniformis, Thermus thermophilus and Thermotoga maritima."
] | [
1991,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Thermoproteota archaeon",
"unclassified sequences"
] | [
20351,
12616,
1,
199
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
4,
1,
4,
3
] | 4 | true | Conserved_site | Large ribosomal subunit protein bL33, conserved site | Large ribosomal subunit protein bL33, conserved site | Ribosomal_bL33_CS | 2 |
IPR018265 | 18,265 | Large ribosomal subunit protein bL35, conserved site | Ribosomal_bL35_CS | Conserved_site | 20,704 | false | false | This entry represents a conserved region in the N-terminal section of the large ribosomal subunit protein bL35, previously known as L35, a basic protein of 60 to 70 amino-acid residues [ ]. Like many basic polypeptides, it completely inhibits ornithine decarboxylase when present unbound in the cell, but the inhibitory ... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS00936"
] | [
"RIBOSOMAL_L35"
] | [
20704
] | 1 | [] | [] | [] | 0 | [
"1nkw",
"1nwx",
"1nwy",
"1sm1",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1xbp",
"2j28",
"2rdo",
"2zjp",
"2zjq",
"2zjr",
"3bbx",
"3cf5",
"3dll",
"3j5l",
"3j7z",
"3j8g",
"3j9w",
"3j9y",
"3j9z",
"3ja1",
"3jbu",
"3jbv",
"3jcd",
"3jce",
"3jcj",
"3jcn",
"3pio"... | 1,090 | [
"PUB00000333",
"PUB00000584",
"PUB00007068",
"PUB00007069",
"PUB00007070"
] | [
"2271612",
"3542048",
"11297922",
"11290319",
"11114498"
] | [
"Ribosomal protein L35: identification in spinach chloroplasts and isolation of a cDNA clone encoding its cytoplasmic precursor.",
"Nonspecific inhibition of Escherichia coli ornithine decarboxylase by various ribosomal proteins: detection of a new ribosomal protein possessing strong antizyme activity.",
"Atomi... | [
1990,
1987,
2001,
2001,
2000
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctjdk2",
"unclassified sequences"
] | [
19074,
1289,
1,
340
] | 4 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
2,
1,
2,
7
] | 4 | true | Conserved_site | Large ribosomal subunit protein bL35, conserved site | Large ribosomal subunit protein bL35, conserved site | Ribosomal_bL35_CS | 2 |
IPR018266 | 18,266 | Large ribosomal subunit protein eL33, conserved site | Ribosomal_eL33_CS | Conserved_site | 4,241 | false | false | The ribosomal eL33 eukaryotic and archaebacterial ribosomal proteins, previously known as L35A, can be grouped on the basis of sequence similarities. One of these families consists of: Vertebrate eL33 (old name L35A). Caenorhabditis elegans eL33 (old name L35A (F10E7.7)). Saccharomyces cerevisiae eL33A/eL33B (old name ... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS01105"
] | [
"RIBOSOMAL_L35AE"
] | [
4241
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
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"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-72689",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-72689",
"R-CEL-72706",
"R-CEL-975956",
"R-CEL-975957",
"R-HSA-156827",
"R-HSA-156902",
"R-HSA-1799339",
"R-HSA-192823",
"R-HSA-240... | [
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-1799339",
"REACTOME:R-CEL-72689",
"REACTOME:R-CEL-72706",
"REACTOME:R-CEL-9759... | 45 | [
"1sqr",
"2lp6",
"3j6x",
"3j6y",
"3j77",
"3j78",
"3j7o",
"3j7p",
"3j7q",
"3j7r",
"3j92",
"3jag",
"3jah",
"3jai",
"3jaj",
"3jan",
"3jct",
"4d5y",
"4d67",
"4u3m",
"4u3n",
"4u3u",
"4u4n",
"4u4o",
"4u4q",
"4u4r",
"4u4u",
"4u4y",
"4u4z",
"4u50",
"4u51",
"4u52"... | 546 | [
"PUB00004463",
"PUB00007068",
"PUB00007069",
"PUB00007070"
] | [
"7899076",
"11297922",
"11290319",
"11114498"
] | [
"Novel protein families in archaean genomes.",
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins."
] | [
1995,
2001,
2001,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Eukaryota",
"Nocardioides antri"
] | [
42,
4198,
1
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
1,
1,
1,
2,
4,
1,
6,
12,
2,
2,
21
] | 12 | true | Conserved_site | Large ribosomal subunit protein eL33, conserved site | Large ribosomal subunit protein eL33, conserved site | Ribosomal_eL33_CS | 9 |
IPR018267 | 18,267 | Large ribosomal subunit protein eL37, conserved site | Ribosomal_eL37_CS | Conserved_site | 5,344 | false | false | A number of eukaryotic and archaeal ribosomal proteins can be grouped on the basis of sequence similarities. This family represents the large ribosomal subunit protein eL37 (also known as L37) [ ], which consists of proteins of 56 to 96 amino-acid residues that share a highly conserved region located in the N-terminal ... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS01077"
] | [
"RIBOSOMAL_L37E"
] | [
5344
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-72689",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-DDI-156827",
"R-DDI-1799339",
"R-DDI-72689",
"R-DDI-72706",
"R-DDI-975956",
"R-DDI-975957",
"R-DME-156827",
"R-DME-1799339",
"R-DME-72689",
"R-DME-72706",
"R-DME-97595... | [
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-DDI-156827",
"REACTOME:R-DDI-1799339",
"REACTOME:R-DDI-72689",
"REACTOME:R-DDI-72706",
"REACTOME:R-DDI-9759... | 58 | [
"1ffk",
"1jj2",
"1k73",
"1k8a",
"1k9m",
"1kc8",
"1kd1",
"1kqs",
"1m1k",
"1m90",
"1n8r",
"1nji",
"1q7y",
"1q81",
"1q82",
"1q86",
"1qvf",
"1qvg",
"1s72",
"1vq4",
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"1vq9",
"1vqk",
"1vql",
"1vqm",
"1vqn",
"1vqo",
"1vqp",
"1w2b"... | 673 | [
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00080279"
] | [
"11297922",
"11290319",
"11114498",
"24524803"
] | [
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins.",
"A new system for naming ribosomal proteins."
] | [
2001,
2001,
2000,
2014
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
717,
3,
4615,
9
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
11,
2,
1,
5,
3,
1,
1,
6,
4,
2,
2,
13
] | 12 | true | Conserved_site | Large ribosomal subunit protein eL37, conserved site | Large ribosomal subunit protein eL37, conserved site | Ribosomal_eL37_CS | 2 |
IPR018268 | 18,268 | Small ribosomal subunit protein uS10, conserved site | Ribosomal_uS10_CS | Conserved_site | 26,471 | false | false | This entry represents a conserved region located at the central part of uS10 proteins. Evidence suggests that, in prokaryotes, the peptidyl transferase reaction is performed by the large subunit 23S rRNA, whereas proteins probably have a greater role in eukaryotic ribosomes. Most of the proteins lie close to, or on the... | [
"GO:0003723",
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"RNA binding",
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"molecular_function",
"biological_process",
"cellular_component"
] | 4 | [
"PROSITE"
] | [
"PS00361"
] | [
"RIBOSOMAL_S10"
] | [
26471
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-72649",
"R-BTA-72689",
"R-BTA-72695",
"R-BTA-72702",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-DME-156827",
"R-DME-1799339",
"R-DME-72649",
"R-DME-72689",
"R-DME-72695",
"R-DME-72702",
"R-DME-72706",
"R-DME-975956",
... | [
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72649",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72695",
"REACTOME:R-BTA-72702",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-DME-156827",
"REACTOME:R-DME-179933... | 66 | [
"1fjg",
"1hnw",
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"1hr0",
"1i94",
"1i95",
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"1ibk",
"1ibl",
"1ibm",
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"1jgq",
"1ml5",
"1n32",
"1n33",
"1n34",
"1n36",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1xmo",
"1xmq",
"1xnq",
"1xnr",
"2e5l",
"2f4v"... | 1,647 | [
"PUB00003326",
"PUB00003381",
"PUB00004907",
"PUB00005065",
"PUB00007068",
"PUB00007069",
"PUB00007070"
] | [
"8021936",
"9281425",
"9371771",
"2179947",
"11297922",
"11290319",
"11114498"
] | [
"Suppression of yeast RNA polymerase III mutations by the URP2 gene encoding a protein homologous to the mammalian ribosomal protein S20.",
"A new model for the three-dimensional folding of Escherichia coli 16 S ribosomal RNA. II. The RNA-protein interaction data.",
"Proteins on ribosome surface: measurements o... | [
1994,
1997,
1997,
1990,
2001,
2001,
2000
] | 7 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
714,
21182,
4229,
346
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae... | [
9,
1,
2,
1,
3,
2,
1,
3,
9,
1,
8
] | 11 | true | Conserved_site | Small ribosomal subunit protein uS10, conserved site | Small ribosomal subunit protein uS10, conserved site | Ribosomal_uS10_CS | 4 |
IPR018270 | 18,270 | Concentrative nucleoside transporter, metazoan/bacterial | C_nuclsd_transpt_met_bac | Family | 7,909 | false | false | Nucleosides are hydrophilic molecules and require specialised transport proteins for permeation of cell membranes. There are two types of nucleoside transport processes: equilibrative bidirectional processes driven by chemical gradients, and inwardly directed concentrative processes driven by an electrochemical gradien... | [
"GO:0005337",
"GO:1901642",
"GO:0016020"
] | [
"nucleoside transmembrane transporter activity",
"nucleoside transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00804"
] | [
"nupC"
] | [
7909
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-83936",
"R-HSA-9748787",
"R-HSA-9755088",
"R-MMU-83936",
"R-MMU-9748787",
"R-MMU-9755088",
"R-RNO-83936",
"R-RNO-9748787",
"R-RNO-9755088"
] | [
"REACTOME:R-HSA-83936",
"REACTOME:R-HSA-9748787",
"REACTOME:R-HSA-9755088",
"REACTOME:R-MMU-83936",
"REACTOME:R-MMU-9748787",
"REACTOME:R-MMU-9755088",
"REACTOME:R-RNO-83936",
"REACTOME:R-RNO-9748787",
"REACTOME:R-RNO-9755088"
] | 9 | [
"3tij",
"4pb1",
"4pb2",
"4pd5",
"4pd6",
"4pd7",
"4pd8",
"4pd9",
"4pda",
"5l24",
"5l26",
"5l27",
"5l2a",
"5l2b",
"5u9w",
"6ksw",
"8tz1",
"8tz2",
"8tz3",
"8tz4",
"8tz5",
"8tz6",
"8tz7",
"8tz8",
"8tz9",
"8tza",
"8tzd"
] | 27 | [
"PUB00002299",
"PUB00033989",
"PUB00033990",
"PUB00033991",
"PUB00033992",
"PUB00071908"
] | [
"8550462",
"10353709",
"15678184",
"12794928",
"16265592",
"23506887"
] | [
"Dra-nupC-pdp operon of Bacillus subtilis: nucleotide sequence, induction by deoxyribonucleosides, and transcriptional regulation by the deoR-encoded DeoR repressor protein.",
"Recent advances in the molecular biology of nucleoside transporters of mammalian cells.",
"The nucleoside transport proteins, NupC and ... | [
1996,
1998,
2005,
2003,
2005,
2013
] | 6 | [
"IPR008276"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
5437,
2461,
11
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
2,
3,
3,
3,
8,
5,
13
] | 7 | true | Family | Concentrative nucleoside transporter, metazoan/bacterial | Concentrative nucleoside transporter, metazoan/bacterial | C_nuclsd_transpt_met_bac | 5 |
IPR018271 | 18,271 | Small ribosomal subunit protein uS14, conserved site | Ribosomal_uS14_CS | Conserved_site | 36,393 | false | false | uS14 is one of the proteins from the small ribosomal subunit. In Escherichia coli, uS14 is known to be required for the assembly of 30S particles and may also be responsible for determining the conformation of 16S rRNA at the A site. It belongs to a family of ribosomal proteins [ ] that include bacterial, algal and pla... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS00527"
] | [
"RIBOSOMAL_S14"
] | [
36393
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-72649",
"R-BTA-72689",
"R-BTA-72695",
"R-BTA-72702",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-DDI-156827",
"R-DDI-1799339",
"R-DDI-72689",
"R-DDI-72695",
"R-DDI-72702",
"R-DDI-72706",
"R-DDI-975956",
"R-DDI-975957",
... | [
"REACTOME:R-BTA-156827",
"REACTOME:R-BTA-1799339",
"REACTOME:R-BTA-6791226",
"REACTOME:R-BTA-72649",
"REACTOME:R-BTA-72689",
"REACTOME:R-BTA-72695",
"REACTOME:R-BTA-72702",
"REACTOME:R-BTA-72706",
"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-DDI-156827",
"REACTOME:R-DDI-179933... | 74 | [
"1fjg",
"1hnw",
"1hnx",
"1hnz",
"1hr0",
"1i94",
"1i95",
"1i96",
"1i97",
"1ibk",
"1ibl",
"1ibm",
"1j5e",
"1jgo",
"1jgp",
"1jgq",
"1ml5",
"1n32",
"1n33",
"1n34",
"1n36",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1xmo",
"1xmq",
"1xnq",
"1xnr",
"2e5l",
"2f4v"... | 1,658 | [
"PUB00004441"
] | [
"8441676"
] | [
"Zinc finger-like motifs in rat ribosomal proteins S27 and S29."
] | [
1993
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
781,
17816,
17544,
252
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
11,
1,
1,
4,
1,
4,
1,
1,
5,
2,
3,
10
] | 12 | true | Conserved_site | Small ribosomal subunit protein uS14, conserved site | Small ribosomal subunit protein uS14, conserved site | Ribosomal_uS14_CS | 7 |
IPR018272 | 18,272 | PRANC domain | PRANC_domain | Domain | 1,362 | false | false | This presumed domain is found at the C terminus of a variety of Pox virus proteins. The PRANC (Pox proteins Repeats of ANkyrin, C-terminal) domain is also found on its own in some proteins [ ]. The function of this domain is unknown, but it appears to be related to the F-box domain and may play a similar role. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF09372"
] | [
"PRANC"
] | [
1362
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044798"
] | [
"16025237"
] | [
"F-box-like domains are present in most poxvirus ankyrin repeat proteins."
] | [
2005
] | 1 | [] | [] | 0 | 0 | null | [
"Chordopoxvirinae",
"Pancrustacea",
"Pseudomonadota"
] | [
1120,
125,
117
] | 3 | [] | [] | 0 | true | Domain | PRANC domain | PRANC domain | PRANC_domain | 8 |
IPR018273 | 18,273 | Small ribosomal subunit protein eS17, conserved site | Ribosomal_eS17_CS | Conserved_site | 5,794 | false | false | A number of eukaryotic and archaebacterial ribosomal proteins can be grouped in this family of ribosomal proteins, eS17 (RPS17) [ ]. They include, vertebrate, Drosophila and Neurospora crassa (crp-3) eS17's as well as yeast eS17a (RP51A) and eS17b (RP51B) [ ] and archaebacterial eS17 [ , , ]. Ribosomes are the particle... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS00712"
] | [
"RIBOSOMAL_S17E"
] | [
5794
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-72649",
"R-CEL-72689",
"R-CEL-72695",
"R-CEL-72702",
"R-CEL-72706",
"R-CEL-975956",
"R-CEL-975957",
"R-CFA-156827",
"R-CFA-1799339",
"R-CFA-72649",
"R-CFA-72689",
"R-CFA-72695",
"R-CFA-72702",
"R-CFA-72706",
"R-CFA-975956",
"R-CFA-975957",
... | [
"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-1799339",
"REACTOME:R-CEL-72649",
"REACTOME:R-CEL-72689",
"REACTOME:R-CEL-72695",
"REACTOME:R-CEL-72702",
"REACTOME:R-CEL-72706",
"REACTOME:R-CEL-975956",
"REACTOME:R-CEL-975957",
"REACTOME:R-CFA-156827",
"REACTOME:R-CFA-1799339",
"REACTOME:R-CFA-72649"... | 108 | [
"1rq6",
"3j6x",
"3j6y",
"3j77",
"3j78",
"3j7a",
"3j7p",
"3j7r",
"3j80",
"3j81",
"3jag",
"3jah",
"3jai",
"3jaj",
"3jam",
"3jan",
"3jap",
"3jbn",
"3jbo",
"3jbp",
"4bts",
"4d5l",
"4d61",
"4kzx",
"4kzy",
"4kzz",
"4u3m",
"4u3n",
"4u3u",
"4u4n",
"4u4o",
"4u4q"... | 536 | [
"PUB00001768",
"PUB00001776",
"PUB00003645",
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00059102",
"PUB00080279"
] | [
"3240863",
"2507396",
"6092944",
"11297922",
"11290319",
"11114498",
"22096102",
"24524803"
] | [
"The transcriptionally active human ribosomal protein S17 gene.",
"The Drosophila melanogaster RPS17 gene encoding ribosomal protein S17.",
"Two genes for ribosomal protein 51 of Saccharomyces cerevisiae complement and contribute to the ribosomes.",
"Atomic structures at last: the ribosome in 2000.",
"The r... | [
1988,
1989,
1984,
2001,
2001,
2000,
2011,
2014
] | 8 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
594,
5,
5186,
9
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizo... | [
9,
1,
2,
1,
4,
4,
1,
9,
2,
2
] | 10 | true | Conserved_site | Small ribosomal subunit protein eS17, conserved site | Small ribosomal subunit protein eS17, conserved site | Ribosomal_eS17_CS | 7 |
IPR018274 | 18,274 | PEP-utilising enzyme, active site | PEP_util_AS | Active_site | 40,392 | false | false | A number of enzymes that catalyze the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) via a phospho-histidine intermediate have been shown to be structurally related [ , , , ]. These enzymes are: Pyruvate,orthophosphate dikinase ( ) (PPDK). PPDK catalyzes the reversible phosphorylation of pyruvate and pho... | [
"GO:0016772",
"GO:0016310"
] | [
"transferase activity, transferring phosphorus-containing groups",
"phosphorylation"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROSITE"
] | [
"PS00370"
] | [
"PEP_ENZYMES_PHOS_SITE"
] | [
40392
] | 1 | [] | [] | [] | 0 | [
"1dik",
"1eza",
"1ezb",
"1ezc",
"1ezd",
"1jde",
"1kbl",
"1kc7",
"1vbg",
"1vbh",
"1zym",
"2dik",
"2eza",
"2ezb",
"2ezc",
"2fm4",
"2hro",
"2hwg",
"2kx9",
"2mp0",
"2n5t",
"2ols",
"2r82",
"2x0s",
"2xdf",
"3eza",
"3ezb",
"3eze",
"5jvj",
"5jvl",
"5jvn",
"5lu4"... | 36 | [
"PUB00000317",
"PUB00001868",
"PUB00005010",
"PUB00017924"
] | [
"2176881",
"8973315",
"7686067",
"1310524"
] | [
"Analysis of sequence homologies in plant and bacterial pyruvate phosphate dikinase, enzyme I of the bacterial phosphoenolpyruvate: sugar phosphotransferase system and other PEP-utilizing enzymes. Identification of potential catalytic and regulatory motifs.",
"Novel phosphotransferase-encoding genes revealed by a... | [
1990,
1996,
1993,
1992
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
1058,
37083,
1763,
5,
483
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
6,
4,
6,
60
] | 4 | true | Active_site | PEP-utilising enzyme, active site | PEP-utilising enzyme, active site | PEP_util_AS | 9 |
IPR018275 | 18,275 | Small ribosomal subunit protein bS18, conserved site | Ribosomal_bS18_CS | Conserved_site | 31,808 | false | false | The small ribosomal subunit protein bS18 (previously known as S18) is known to be involved in binding the aminoacyl-tRNA complex in Escherichia coli [ ], and appears to be situated at the tRNA A-site. Experimental evidence has revealed that bS18 is well exposed on the surface of the E. coli ribosome, and is a secondary... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS00057"
] | [
"RIBOSOMAL_S18"
] | [
31808
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5389840",
"R-BTA-5419276",
"R-BTA-9937383",
"R-HSA-5368286",
"R-HSA-5389840",
"R-HSA-5419276",
"R-HSA-9937383",
"R-MMU-5389840",
"R-MMU-5419276",
"R-MMU-9937383"
] | [
"REACTOME:R-BTA-5389840",
"REACTOME:R-BTA-5419276",
"REACTOME:R-BTA-9937383",
"REACTOME:R-HSA-5368286",
"REACTOME:R-HSA-5389840",
"REACTOME:R-HSA-5419276",
"REACTOME:R-HSA-9937383",
"REACTOME:R-MMU-5389840",
"REACTOME:R-MMU-5419276",
"REACTOME:R-MMU-9937383"
] | 10 | [
"1fjg",
"1fka",
"1g1x",
"1hnw",
"1hnx",
"1hnz",
"1hr0",
"1i94",
"1i95",
"1i96",
"1i97",
"1ibk",
"1ibl",
"1ibm",
"1j5e",
"1jgo",
"1jgp",
"1jgq",
"1ml5",
"1n32",
"1n33",
"1n34",
"1n36",
"1vvj",
"1vy4",
"1vy5",
"1vy6",
"1vy7",
"1x18",
"1xmo",
"1xmq",
"1xnq"... | 1,250 | [
"PUB00001566",
"PUB00003381",
"PUB00004907",
"PUB00005065",
"PUB00007068",
"PUB00007069",
"PUB00007070",
"PUB00151135"
] | [
"2647521",
"9281425",
"9371771",
"2179947",
"11297922",
"11290319",
"11114498",
"27023846"
] | [
"The complete amino acid sequence of ribosomal protein S18 from the moderate thermophile Bacillus stearothermophilus.",
"A new model for the three-dimensional folding of Escherichia coli 16 S ribosomal RNA. II. The RNA-protein interaction data.",
"Proteins on ribosome surface: measurements of protein exposure b... | [
1989,
1997,
1997,
1990,
2001,
2001,
2000,
2016
] | 8 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
19184,
12379,
245
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
4,
1,
2,
1,
2,
2,
4,
2
] | 8 | true | Conserved_site | Small ribosomal subunit protein bS18, conserved site | Small ribosomal subunit protein bS18, conserved site | Ribosomal_bS18_CS | 9 |
IPR018276 | 18,276 | DET1- and DDB1-associated protein 1 domain | DDA1_dom | Domain | 2,960 | false | false | This entry represents the DDA1 domain described in DET1- and DDB1-associated protein 1 ubiquitin ligases. DDA1 is a core subunit of multiple Cul4-based E3 ligases (CRL4s), involved in ubiquitination and subsequent proteasomal degradation of target proteins, which regulate key developmental and stress responses in eukar... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10172"
] | [
"DDA1"
] | [
2960
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-8951664",
"R-DRE-8951664",
"R-HSA-8951664",
"R-MMU-8951664"
] | [
"REACTOME:R-BTA-8951664",
"REACTOME:R-DRE-8951664",
"REACTOME:R-HSA-8951664",
"REACTOME:R-MMU-8951664"
] | 4 | [
"6dsz",
"6pai",
"6q0r",
"6q0v",
"6q0w",
"6sj7",
"6ud7",
"6ue5",
"8g46",
"8qh5",
"8rox",
"8roy",
"8tl6",
"9bjz",
"9bz0",
"9c5u",
"9c5v",
"9dhd",
"9fd2"
] | 19 | [
"PUB00044222",
"PUB00079133",
"PUB00079134",
"PUB00153154"
] | [
"17452440",
"24563205",
"19295130",
"31102784"
] | [
"Mammalian DET1 regulates Cul4A activity and forms stable complexes with E2 ubiquitin-conjugating enzymes.",
"Targeted degradation of abscisic acid receptors is mediated by the ubiquitin ligase substrate adaptor DDA1 in Arabidopsis.",
"An interaction network of the mammalian COP9 signalosome identifies Dda1 as ... | [
2007,
2014,
2009,
2019
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
2960
] | 1 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
10,
2,
1,
1,
2,
8,
5,
17
] | 8 | true | Domain | DET1- and DDB1-associated protein 1 domain | DET1- and DDB1-associated protein 1 domain | DDA1_dom | 7 |
IPR018277 | 18,277 | Small ribosomal subunit protein eS19, conserved site | Ribosomal_eS19_CS | Conserved_site | 4,129 | false | false | This family includes a number of eukaryotic and archaebacterial ribosomal proteins known as small ribosomal subunit protein eS19, which were previously known as S19. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The codons of the mRNA are exposed on the ribosome to allow tR... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS00628"
] | [
"RIBOSOMAL_S19E"
] | [
4129
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-156827",
"R-BTA-1799339",
"R-BTA-6791226",
"R-BTA-72649",
"R-BTA-72689",
"R-BTA-72695",
"R-BTA-72702",
"R-BTA-72706",
"R-BTA-975956",
"R-BTA-975957",
"R-CEL-156827",
"R-CEL-1799339",
"R-CEL-72649",
"R-CEL-72689",
"R-CEL-72695",
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] | [
2001,
2001,
2000
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
433,
6,
3686,
4
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
9,
1,
2,
4,
4,
6,
1,
5,
9,
2,
2,
8
] | 12 | true | Conserved_site | Small ribosomal subunit protein eS19, conserved site | Small ribosomal subunit protein eS19, conserved site | Ribosomal_eS19_CS | 3 |
IPR018279 | 18,279 | Small ribosomal subunit protein eS21, conserved site | Ribosomal_eS21_CS | Conserved_site | 3,639 | false | false | A number of eukaryotic ribosomal proteins can be grouped on the basis of sequence similarities. These proteins have 82 to 87 amino acids. The amino termini are all N alpha-acetylated. The N-terminal halves of the protein molecules are highly conserved in contrast to the carboxy-terminal parts [ ]. Ribosomes are the par... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
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"translation",
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] | [
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"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS00996"
] | [
"RIBOSOMAL_S21E"
] | [
3639
] | 1 | [
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"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-179933... | 108 | [
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"4u4z",
"4u50",
"4u51"... | 469 | [
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"PUB00007068",
"PUB00007069",
"PUB00007070"
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"3910104",
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"11114498"
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"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins."
] | [
1985,
2001,
2001,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
3639
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
4,
6,
2,
1,
8,
5,
2,
1,
27
] | 12 | true | Conserved_site | Small ribosomal subunit protein eS21, conserved site | Small ribosomal subunit protein eS21, conserved site | Ribosomal_eS21_CS | 7 |
IPR018280 | 18,280 | Small ribosomal subunit protein uS3, conserved site | Ribosomal_uS3_CS | Conserved_site | 44,385 | false | false | This entry represents a conserved site that is part of the C-terminal domain ( ) of the small ribosomal subunit protein uS3. Small ribosomal subunit protein uS3 was previously known as Ribosomal protein S3. In Escherichia coli, S3 is known to be involved in the binding of initiator Met-tRNA. This family of ribosomal pr... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00548"
] | [
"RIBOSOMAL_S3"
] | [
44385
] | 1 | [
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"REACTOME",
"REACTOM... | [
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"R-CEL-72702",
"R-CEL-72706",
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"REACTOME:R-BTA-72702",
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"REACTOME:R-BTA-975956",
"REACTOME:R-BTA-975957",
"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-179933... | 102 | [
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"1xmo",
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"2f4v"... | 1,627 | [
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"Conserved structures and diversity of functions of RNA-binding proteins.",
"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins."
] | [
1994,
2001,
2001,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
387,
23238,
20219,
541
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
5,
1,
1,
3,
1,
6,
7,
1,
12,
8,
1,
1,
14
] | 13 | true | Conserved_site | Small ribosomal subunit protein uS3, conserved site | Small ribosomal subunit protein uS3, conserved site | Ribosomal_uS3_CS | 8 |
IPR018281 | 18,281 | Small ribosomal subunit protein eS1, conserved site | Ribosomal_eS1_CS | Conserved_site | 5,301 | false | false | This entry represents the conserved site found in the small ribosomal subunit protein eS1 (known as S3A). A number of eukaryotic and archaebacterial ribosomal proteins can be grouped on the basis of sequence similarities. Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The co... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS01191"
] | [
"RIBOSOMAL_S3AE"
] | [
5301
] | 1 | [
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"R-CEL-72702",
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"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-179933... | 101 | [
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"4u55"... | 542 | [
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"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins."
] | [
2001,
2001,
2000
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
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379,
11,
4909,
2
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
4,
1,
1,
1,
13,
6,
1,
9,
7,
2,
2,
17
] | 12 | true | Conserved_site | Small ribosomal subunit protein eS1, conserved site | Small ribosomal subunit protein eS1, conserved site | Ribosomal_eS1_CS | 4 |
IPR018282 | 18,282 | Small ribosomal subunit protein eS6, conserved site | Ribosomal_eS6_CS | Conserved_site | 6,328 | false | false | A number of eukaryotic and archaeal ribosomal proteins have been grouped on the basis of sequence similarities. Small ribosomal subunit protein eS6, previously known as Ribosomal protein S6 is the major substrate of protein kinases in eukaryotic ribosomes [ ] and may play an important role in controlling cell growth an... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS00578"
] | [
"RIBOSOMAL_S6E"
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6328
] | 1 | [
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"REACTOME:R-BTA-9629569",
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"REACTOME:R-BTA-97595... | 103 | [
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"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins."
] | [
1993,
2001,
2001,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
644,
10,
5647,
27
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"... | [
3,
1,
5,
4,
4,
2,
4,
10,
2,
2,
12
] | 11 | true | Conserved_site | Small ribosomal subunit protein eS6, conserved site | Small ribosomal subunit protein eS6, conserved site | Ribosomal_eS6_CS | 4 |
IPR018283 | 18,283 | Small ribosomal subunit protein eS8, conserved site | Ribosomal_eS8_CS | Conserved_site | 4,638 | false | false | This entry represents the small ribosomal subunit protein eS8 from archaea and eukaryotes [ , ], which consists of a number of proteins with either about 220 amino acids (in eukaryotes) or about 125 amino acids (in archaea). Ribosomes are the particles that catalyse mRNA-directed protein synthesis in all organisms. The... | [
"GO:0003735",
"GO:0006412",
"GO:0005840"
] | [
"structural constituent of ribosome",
"translation",
"ribosome"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS01193"
] | [
"RIBOSOMAL_S8E"
] | [
4638
] | 1 | [
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"REACTOME:R-BTA-975957",
"REACTOME:R-CEL-156827",
"REACTOME:R-CEL-179933... | 84 | [
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"Atomic structures at last: the ribosome in 2000.",
"The ribosome in focus.",
"The end of the beginning: structural studies of ribosomal proteins.",
"Structures o... | [
1995,
2001,
2001,
2000,
2013
] | 5 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
492,
4,
4132,
10
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea ma... | [
5,
1,
2,
2,
3,
7,
3,
6,
2,
2,
9
] | 11 | true | Conserved_site | Small ribosomal subunit protein eS8, conserved site | Small ribosomal subunit protein eS8, conserved site | Ribosomal_eS8_CS | 1 |
IPR018285 | 18,285 | Methionyl-tRNA synthetase, N-terminal heteromerisation domain | Met-tRNA-synth_N | Domain | 110 | false | false | This entry represents the N-terminal domain of methionyl-tRNA synthetase (MetRS). This N-terminal appended domain mediates non-catalytic complex formation through its interaction with a domain in the tRNA aminoacylation cofactor Arc1p. The interacting domains of MetRS, GluRS (glutamyl-tRNA synthetase) and Arc1p form a ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF09635"
] | [
"MetRS-N"
] | [
110
] | 1 | [] | [] | [] | 0 | [
"2hsn"
] | 1 | [
"PUB00041484"
] | [
"16914447"
] | [
"Structural basis of yeast aminoacyl-tRNA synthetase complex formation revealed by crystal structures of two binary sub-complexes."
] | [
2006
] | 1 | [] | [] | 0 | 0 | null | [
"Dikarya"
] | [
110
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Domain | Methionyl-tRNA synthetase, N-terminal heteromerisation domain | Methionyl-tRNA synthetase, N-terminal heteromerisation domain | Met-tRNA-synth_N | 5 |
IPR018287 | 18,287 | Hap4 transcription factor, heteromerisation domain | Hap4_TF_heteromerisation | Domain | 1,501 | false | false | This entry represents an essential domain of the transcription activator Hap4 that allows it to associate with Hap2, Hap3 and Hap5 to form the Hap complex [ , ]. In Saccharomyces cerevisiae (Baker's yeast), the haem-activated protein complex Hap2/3/4/5 plays a major role in the transcription of genes involved in respir... | [
"GO:0006355",
"GO:0005634"
] | [
"regulation of DNA-templated transcription",
"nucleus"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"PFAM"
] | [
"PF10297"
] | [
"Hap4_Hap_bind"
] | [
1501
] | 1 | [] | [] | [] | 0 | [
"7aw7",
"7aw9"
] | 2 | [
"PUB00044295",
"PUB00044296",
"PUB00044799"
] | [
"16522629",
"16278450",
"2676721"
] | [
"Hap4 is not essential for activation of respiration at low specific growth rates in Saccharomyces cerevisiae.",
"Assembly of the Hap2p/Hap3p/Hap4p/Hap5p-DNA complex in Saccharomyces cerevisiae.",
"Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer."
] | [
2006,
2005,
1989
] | 3 | [] | [] | 0 | 0 | null | [
"Bradyrhizobium archetypum",
"Eukaryota"
] | [
1,
1500
] | 2 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
2,
1
] | 3 | true | Domain | Hap4 transcription factor, heteromerisation domain | Hap4 transcription factor, heteromerisation domain | Hap4_TF_heteromerisation | 5 |
IPR018288 | 18,288 | F420-dehydrogenase, subunit FpoO | F420H2-DH_FpoO | Family | 83 | false | false | This entry represents the FpoO subunit of membrane-bound multi-subunit F420H2 dehydrogenase, which oxidises the reduced coenzyme F420H2 to coenzyme F420 and feeds the electrons via an FeS cluster into an energy-conserving electron transport chain [ , ]. This enzyme plays a role in the methanogenic pathway in methanogen... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10621"
] | [
"FpoO"
] | [
83
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00009994",
"PUB00043561",
"PUB00044673",
"PUB00044800"
] | [
"10751389",
"10940377",
"15168610",
"9933933"
] | [
"The F420H2 dehydrogenase from Methanosarcina mazei is a Redox-driven proton pump closely related to NADH dehydrogenases.",
"The respiratory complex I of bacteria, archaea and eukarya and its module common with membrane-bound multisubunit hydrogenases.",
"The membrane-bound electron transport system of Methanos... | [
2000,
2000,
2004,
1999
] | 4 | [] | [] | 0 | 0 | null | [
"Aedes albopictus",
"Methanobacteriota",
"hydrocarbon metagenome"
] | [
1,
81,
1
] | 3 | [] | [] | 0 | true | Family | F420-dehydrogenase, subunit FpoO | F420-dehydrogenase, subunit FpoO | F420H2-DH_FpoO | 7 |
IPR018289 | 18,289 | MULE transposase domain | MULE_transposase_dom | Domain | 53,549 | false | false | This entry represents a domain found in Mutator-like elements (MULE)-encoded tranposases, some of which also contain a zinc-finger motif [ , ]. This domain is also found in a transposase for the insertion sequence element IS256 in transposon Tn4001 [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10551"
] | [
"MULE"
] | [
53549
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044386",
"PUB00044801",
"PUB00044802"
] | [
"17130173",
"15755923",
"11751820"
] | [
"The natural history of the WRKY-GCM1 zinc fingers and the relationship between transcription factors and transposons.",
"Mutator-like element in the yeast Yarrowia lipolytica displays multiple alternative splicings.",
"Diversity of Tn4001 transposition products: the flanking IS256 elements can form tandem dime... | [
2006,
2005,
2002
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Viruses incertae sedis",
"marine sediment metagenome"
] | [
43,
53451,
48,
3,
4
] | 5 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
230,
564,
72
] | 3 | true | Domain | MULE transposase domain | MULE transposase domain | MULE_transposase_dom | 9 |
IPR018290 | 18,290 | MULE transposase, N-terminal all-beta domain | MULE_transposase_N | Domain | 372 | false | false | This entry represents a domain with an all-β structure that is found in Mutator-like elements (MULE)-encoded tranposases, some of which also contain a zinc-finger motif [ , ]. This domain is found associated with the WRKY domain [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10532"
] | [
"Plant_all_beta"
] | [
372
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044386",
"PUB00044801",
"PUB00044803"
] | [
"17130173",
"15755923",
"18523729"
] | [
"The natural history of the WRKY-GCM1 zinc fingers and the relationship between transcription factors and transposons.",
"Mutator-like element in the yeast Yarrowia lipolytica displays multiple alternative splicings.",
"Studies on DNA-binding selectivity of WRKY transcription factors lend structural clues into ... | [
2006,
2005,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Pentapetalae"
] | [
372
] | 1 | [
"Arabidopsis thaliana"
] | [
44
] | 1 | true | Domain | MULE transposase, N-terminal all-beta domain | MULE transposase, N-terminal all-beta domain | MULE_transposase_N | 1 |
IPR018291 | 18,291 | 5 transmembrane protein, Schizosaccharomyces pombe | 5TM-prot_SCHPO | Family | 8 | false | false | This entry represents a group of proteins containing five transmembrane regions. These proteins are found exclusively in Schizosaccharomyces pombe (Fission yeast). | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF09437"
] | [
"Pombe_5TM"
] | [
8
] | 1 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
8
] | 1 | [
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
8
] | 1 | true | Family | 5 transmembrane protein, Schizosaccharomyces pombe | 5 transmembrane protein, Schizosaccharomyces pombe | 5TM-prot_SCHPO | 3 |
IPR018292 | 18,292 | A-kinase anchor 110kDa, C-terminal | AKAP_110_C | Domain | 1,849 | false | false | null | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF05716"
] | [
"AKAP_110"
] | [
1849
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00011239"
] | [
"10319321"
] | [
"Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
1849
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
8,
9,
14
] | 3 | true | Domain | A-kinase anchor 110kDa, C-terminal | A-kinase anchor 110kDa, C-terminal | AKAP_110_C | 2 |
IPR018293 | 18,293 | 43kDa postsynaptic, conserved site | Postsynaptic_CS | Conserved_site | 992 | false | false | The 43kDa postsynaptic protein is a peripheral membrane protein thought to be involved in the anchoring or stabilisation of the nicotinic acetylcholine receptor at synaptic sites [ ]. It may link the receptor to the postsynaptic cytoskeleton through direct association with actin or spectrin. The 43kDa protein is highly... | [
"GO:0033130",
"GO:0045202"
] | [
"acetylcholine receptor binding",
"synapse"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PROSITE"
] | [
"PS00405"
] | [
"43_KD_POSTSYNAPTIC"
] | [
992
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00001573"
] | [
"2737281"
] | [
"Expression of RNA transcripts for the postsynaptic 43 kDa protein in innervated and denervated rat skeletal muscle."
] | [
1989
] | 1 | [] | [] | 0 | 0 | null | [
"Gnathostomata"
] | [
992
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
8,
3,
5
] | 4 | true | Conserved_site | 43kDa postsynaptic, conserved site | 43kDa postsynaptic, conserved site | Postsynaptic_CS | 4 |
IPR018295 | 18,295 | FLAP/GST2/LTC4S, conserved site | FLAP/GST2/LTC4S_CS | Conserved_site | 581 | false | false | These are proteins of 150 to 160 residues that contain three transmembrane segments. As a signature for these proteins a conserved region between the first and second transmembrane domains has been used. | [
"GO:0008047",
"GO:0006691",
"GO:0016020"
] | [
"enzyme activator activity",
"leukotriene metabolic process",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PROSITE"
] | [
"PS01297"
] | [
"FLAP_GST2_LTC4S"
] | [
581
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-2142688",
"R-BTA-2142691",
"R-BTA-2142700",
"R-HSA-156590",
"R-HSA-2142688",
"R-HSA-2142691",
"R-HSA-2142700",
"R-HSA-5423646",
"R-HSA-9026762",
"R-HSA-9026766",
"R-MMU-2142688",
"R-MMU-2142691",
"R-MMU-2142700",
"R-MMU-9026762",
"R-MMU-9026766",
"R-RNO-2142688",
"R-RNO-214269... | [
"REACTOME:R-BTA-2142688",
"REACTOME:R-BTA-2142691",
"REACTOME:R-BTA-2142700",
"REACTOME:R-HSA-156590",
"REACTOME:R-HSA-2142688",
"REACTOME:R-HSA-2142691",
"REACTOME:R-HSA-2142700",
"REACTOME:R-HSA-5423646",
"REACTOME:R-HSA-9026762",
"REACTOME:R-HSA-9026766",
"REACTOME:R-MMU-2142688",
"REACTOME... | 20 | [
"2pno",
"2q7m",
"2q7r",
"2uuh",
"2uui",
"3b29",
"3hkk",
"3leo",
"3pcv",
"4j7t",
"4j7y",
"4jc7",
"4jcz",
"4jrz",
"4nta",
"4ntb",
"4ntf",
"5hv9",
"6r7d",
"6ssr",
"6sss",
"6ssu",
"6ssw",
"6vgc",
"6vgi",
"9g0u",
"9g0v",
"9g14",
"9g1t"
] | 29 | [
"PUB00002968"
] | [
"8703034"
] | [
"Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase."
] | [
1996
] | 1 | [] | [] | 0 | 0 | null | [
"Bilateria"
] | [
581
] | 1 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
5,
3,
8
] | 3 | true | Conserved_site | FLAP/GST2/LTC4S, conserved site | FLAP/GST2/LTC4S, conserved site | FLAP/GST2/LTC4S_CS | 5 |
IPR018296 | 18,296 | Acid phosphatase, class A, bacterial, conserved site | Acid_Pase_classA_bac_CS | Conserved_site | 1,323 | false | false | Class A bacterial acid phosphatases ( ) are a group of related proteins that catalyse the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate [ , ]. This reaction is non-specific and occurs in the periplasm. The enzyme is found as a homotetramer in Morganella morganii (Proteus morganii... | [
"GO:0003993",
"GO:0030288"
] | [
"acid phosphatase activity",
"outer membrane-bounded periplasmic space"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PROSITE"
] | [
"PS01157"
] | [
"ACID_PHOSPH_CL_A"
] | [
1323
] | 1 | [
"EC",
"METACYC"
] | [
"3.1.3.2",
"PWY-6348"
] | [
"EC:3.1.3.2",
"METACYC:PWY-6348"
] | 2 | [
"1d2t",
"1eoi",
"1iw8",
"2a96",
"2akc",
"8yc1",
"9jq0"
] | 7 | [
"PUB00002155",
"PUB00003588"
] | [
"1938882",
"8081499"
] | [
"Molecular analysis of the Salmonella typhimurium phoN gene, which encodes nonspecific acid phosphatase.",
"Characterization and sequence of PhoC, the principal phosphate-irrepressible acid phosphatase of Morganella morganii."
] | [
1991,
1994
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
1316,
4,
3
] | 3 | [] | [] | 0 | true | Conserved_site | Acid phosphatase, class A, bacterial, conserved site | Acid phosphatase, class A, bacterial, conserved site | Acid_Pase_classA_bac_CS | 4 |
IPR018297 | 18,297 | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | A/G_cyclase_CS | Conserved_site | 41,674 | false | false | Guanylate cyclases ( ) [ , , , ] catalyze the formation of cyclic GMP (cGMP) from GTP. cGMP acts as an intracellular messenger, activating cGMP-dependent kinases and regulating CGMP-sensitive ion channels. The role of cGMP as a second messenger in vascular smooth muscle relaxation and retinal photo-transduction is well... | [
"GO:0016849",
"GO:0009190",
"GO:0035556"
] | [
"phosphorus-oxygen lyase activity",
"cyclic nucleotide biosynthetic process",
"intracellular signal transduction"
] | [
"molecular_function",
"biological_process",
"biological_process"
] | 3 | [
"PROSITE"
] | [
"PS00452"
] | [
"GUANYLATE_CYCLASE_1"
] | [
41674
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"4.6.1.2",
"R-BTA-163615",
"R-BTA-170660",
"R-BTA-170670",
"R-BTA-418597",
"R-BTA-445355",
"R-BTA-5578768",
"R-BTA-5610787",
"R-CEL-2514859",
"R-CFA-445355",
"R-DDI-163615",
"R-DDI-170660",
"R-DDI-170670",
"R-DDI-2514859",
"R-DDI-418597",
"R-DDI-5610787",
"R-DME-163615",
"R-DME-170... | [
"EC:4.6.1.2",
"REACTOME:R-BTA-163615",
"REACTOME:R-BTA-170660",
"REACTOME:R-BTA-170670",
"REACTOME:R-BTA-418597",
"REACTOME:R-BTA-445355",
"REACTOME:R-BTA-5578768",
"REACTOME:R-BTA-5610787",
"REACTOME:R-CEL-2514859",
"REACTOME:R-CFA-445355",
"REACTOME:R-DDI-163615",
"REACTOME:R-DDI-170660",
... | 67 | [
"1ab8",
"1azs",
"1cjk",
"1cjt",
"1cju",
"1cjv",
"1cs4",
"1cul",
"1tl7",
"1u0h",
"1yk9",
"2gvd",
"2gvz",
"2wz1",
"3c14",
"3c15",
"3c16",
"3et6",
"3g82",
"3maa",
"3uvj",
"4ni2",
"4p2f",
"4p2m",
"4p2x",
"5o5k",
"5o5l",
"6jt0",
"6jt1",
"6jt2",
"6pas",
"6pat"... | 72 | [
"PUB00000129",
"PUB00000877",
"PUB00001511",
"PUB00001523",
"PUB00004322",
"PUB00004943"
] | [
"1349465",
"1356629",
"1680765",
"8330684",
"1982420",
"7863008"
] | [
"Guanylyl cyclase-linked receptors.",
"Guanylyl cyclase receptors and their endocrine, paracrine, and autocrine ligands.",
"Guanylyl cyclases, a growing family of signal-transducing enzymes.",
"Molecular and functional diversity of mammalian Gs-stimulated adenylyl cyclases.",
"The guanylyl cyclase receptor ... | [
1992,
1992,
1991,
1993,
1990,
1994
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
2641,
39024,
9
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
38,
146,
56,
70,
55,
94
] | 6 | true | Conserved_site | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | Adenylyl cyclase class-4/guanylyl cyclase, conserved site | A/G_cyclase_CS | 5 |
IPR018298 | 18,298 | Adrenodoxin, iron-sulphur binding site | Adrenodoxin_Fe-S_BS | Binding_site | 14,022 | false | false | null | [
"GO:0051537",
"GO:0140647"
] | [
"2 iron, 2 sulfur cluster binding",
"P450-containing electron transport chain"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROSITE"
] | [
"PS00814"
] | [
"ADX"
] | [
14022
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1362409",
"R-BTA-196108",
"R-BTA-211976",
"R-BTA-2395516",
"R-BTA-9857492",
"R-DME-1362409",
"R-DME-2395516",
"R-DME-9857492",
"R-DRE-1362409",
"R-DRE-196108",
"R-DRE-211976",
"R-DRE-2395516",
"R-HSA-1362409",
"R-HSA-196108",
"R-HSA-211976",
"R-HSA-2395516",
"R-HSA-5579026",
... | [
"REACTOME:R-BTA-1362409",
"REACTOME:R-BTA-196108",
"REACTOME:R-BTA-211976",
"REACTOME:R-BTA-2395516",
"REACTOME:R-BTA-9857492",
"REACTOME:R-DME-1362409",
"REACTOME:R-DME-2395516",
"REACTOME:R-DME-9857492",
"REACTOME:R-DRE-1362409",
"REACTOME:R-DRE-196108",
"REACTOME:R-DRE-211976",
"REACTOME:R-... | 36 | [
"1ayf",
"1b9r",
"1cje",
"1e6e",
"1e9m",
"1gpx",
"1i7h",
"1l6u",
"1l6v",
"1oqq",
"1oqr",
"1pdx",
"1put",
"1r7s",
"1uwm",
"1xln",
"1xlo",
"1xlp",
"1xlq",
"1yji",
"1yjj",
"2bt6",
"2jqr",
"2m56",
"2mj3",
"2mjd",
"2mje",
"2wlb",
"2y5c",
"3hui",
"3lb8",
"3n9y"... | 47 | [
"PUB00002613",
"PUB00002723"
] | [
"2180940",
"1629218"
] | [
"Putidaredoxin reductase and putidaredoxin. Cloning, sequence determination, and heterologous expression of the proteins.",
"Cytochrome P-450terp. Isolation and purification of the protein and cloning and sequencing of its operon."
] | [
1990,
1992
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
7897,
6026,
99
] | 3 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
5,
1,
7,
4,
1,
3,
8,
1,
5,
6,
1,
1,
12
] | 13 | true | Binding_site | Adrenodoxin, iron-sulphur binding site | Adrenodoxin, iron-sulphur binding site | Adrenodoxin_Fe-S_BS | 6 |
IPR018299 | 18,299 | Alkaline phosphatase, active site | Alkaline_phosphatase_AS | Active_site | 12,172 | false | false | Alkaline phosphatase ([ec:EC 3.1.3.1]) (ALP) [ ] is a zinc and magnesium-containing metalloenzyme which hydrolyzes phosphate esters, optimally at high pH. It is found in nearly all living organisms, with the exception of some plants. In Escherichia coli, ALP is found in the periplasmic space. In yeast, it is found in l... | [
"GO:0016791"
] | [
"phosphatase activity"
] | [
"molecular_function"
] | 1 | [
"PROSITE"
] | [
"PS00123"
] | [
"ALKALINE_PHOSPHATASE"
] | [
12172
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.1.3.1",
"PWY-5491",
"R-BTA-163125",
"R-DME-1483166",
"R-DME-6811438",
"R-DME-8935690",
"R-HSA-1483166",
"R-HSA-163125",
"R-HSA-6811438",
"R-HSA-8935690",
"R-MMU-163125",
"R-MMU-6811438",
"R-RNO-1483166",
"R-RNO-163125",
"R-RNO-6811438",
"R-RNO-8935690"
] | [
"EC:3.1.3.1",
"METACYC:PWY-5491",
"REACTOME:R-BTA-163125",
"REACTOME:R-DME-1483166",
"REACTOME:R-DME-6811438",
"REACTOME:R-DME-8935690",
"REACTOME:R-HSA-1483166",
"REACTOME:R-HSA-163125",
"REACTOME:R-HSA-6811438",
"REACTOME:R-HSA-8935690",
"REACTOME:R-MMU-163125",
"REACTOME:R-MMU-6811438",
"... | 16 | [
"1aja",
"1ajb",
"1ajc",
"1ajd",
"1alh",
"1ali",
"1alj",
"1alk",
"1ani",
"1anj",
"1b8j",
"1ed8",
"1ed9",
"1ew2",
"1ew8",
"1ew9",
"1hjk",
"1hqa",
"1k7h",
"1kh4",
"1kh5",
"1kh7",
"1kh9",
"1khj",
"1khk",
"1khl",
"1khn",
"1shn",
"1shq",
"1ura",
"1urb",
"1y6v"... | 73 | [
"PUB00000565",
"PUB00001950",
"PUB00003744"
] | [
"2379681",
"2286375",
"1654502"
] | [
"Alkaline phosphatases.",
"Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes.",
"Genetics of streptomycin production in Streptomyces griseus: nucleotide sequence of five genes, strFGHIK, including a phosphatase gene."
] | [
1990,
1990,
1991
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"metagenomes"
] | [
4914,
7149,
64,
45
] | 4 | [
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe... | [
5,
7,
2,
7,
16,
2,
16,
1,
1,
1
] | 10 | true | Active_site | Alkaline phosphatase, active site | Alkaline phosphatase, active site | Alkaline_phosphatase_AS | 1 |
IPR018300 | 18,300 | Aminotransferase, class IV, conserved site | Aminotrans_IV_CS | Conserved_site | 42,096 | false | false | Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes, such as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped [ ] into subfamilies. One of these, called class-IV, current... | [
"GO:0003824"
] | [
"catalytic activity"
] | [
"molecular_function"
] | 1 | [
"PROSITE"
] | [
"PS00770"
] | [
"AA_TRANSFER_CLASS_4"
] | [
42096
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.6.1.42",
"PWY-5057",
"PWY-5076",
"PWY-5078",
"PWY-5101",
"PWY-5103",
"PWY-5104",
"PWY-5108",
"PWY-7767",
"PWY-8173",
"PWY-8174",
"PWY-8175",
"PWY-8183",
"PWY-8184",
"PWY-8185",
"R-BTA-70895",
"R-CEL-70895",
"R-DDI-70895",
"R-HSA-70895",
"R-MMU-70895",
"R-RNO-70895",
"R-S... | [
"EC:2.6.1.42",
"METACYC:PWY-5057",
"METACYC:PWY-5076",
"METACYC:PWY-5078",
"METACYC:PWY-5101",
"METACYC:PWY-5103",
"METACYC:PWY-5104",
"METACYC:PWY-5108",
"METACYC:PWY-7767",
"METACYC:PWY-8173",
"METACYC:PWY-8174",
"METACYC:PWY-8175",
"METACYC:PWY-8183",
"METACYC:PWY-8184",
"METACYC:PWY-... | 23 | [
"1a3g",
"1daa",
"1ekf",
"1ekp",
"1ekv",
"1et0",
"1i1k",
"1i1l",
"1i1m",
"1i2k",
"1i2l",
"1iyd",
"1iye",
"1kt8",
"1kta",
"2a1h",
"2abj",
"2cog",
"2coi",
"2coj",
"2daa",
"2hdk",
"2hg8",
"2hgw",
"2hgx",
"2hhf",
"3csw",
"3daa",
"3dtf",
"3dtg",
"3ht5",
"3jz6"... | 87 | [
"PUB00000425",
"PUB00002195",
"PUB00002360"
] | [
"7626635",
"1644759",
"9163511"
] | [
"Crystal structure of a D-amino acid aminotransferase: how the protein controls stereoselectivity.",
"Characterization and sequence of Escherichia coli pabC, the gene encoding aminodeoxychorismate lyase, a pyridoxal phosphate-containing enzyme.",
"Three-dimensional structure of Escherichia coli branched-chain a... | [
1995,
1992,
1997
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
677,
31080,
9664,
675
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
39,
2,
15,
1,
2,
8,
11,
1,
18,
19,
2,
1,
28
] | 13 | true | Conserved_site | Aminotransferase, class IV, conserved site | Aminotransferase, class IV, conserved site | Aminotrans_IV_CS | 2 |
IPR018301 | 18,301 | Aromatic amino acid hydroxylase, iron/copper binding site | ArAA_hydroxylase_Fe/CU_BS | Binding_site | 11,670 | false | false | Phenylalanine, tyrosine and tryptophan hydroxylases constitute a family of tetrahydrobiopterin-dependent aromatic amino acid hydroxylases, all of which are rate-limiting catalysts for important metabolic pathways [ ]. The proteins are structurally and functionally related, each containing iron, and catalysing ring hydr... | [
"GO:0004497",
"GO:0005506",
"GO:0009072"
] | [
"monooxygenase activity",
"iron ion binding",
"aromatic amino acid metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PROSITE"
] | [
"PS00367"
] | [
"BH4_AAA_HYDROXYL_1"
] | [
11670
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.14.16",
"R-BTA-8964208",
"R-CEL-209905",
"R-CEL-8964208",
"R-DDI-209905",
"R-DDI-209931",
"R-DDI-8964208",
"R-DME-209905",
"R-DME-8964208",
"R-HSA-209905",
"R-HSA-209931",
"R-HSA-2160456",
"R-HSA-8964208",
"R-HSA-9031628",
"R-MMU-209905",
"R-MMU-209931",
"R-MMU-8964208",
"R-RNO-... | [
"EC:1.14.16",
"REACTOME:R-BTA-8964208",
"REACTOME:R-CEL-209905",
"REACTOME:R-CEL-8964208",
"REACTOME:R-DDI-209905",
"REACTOME:R-DDI-209931",
"REACTOME:R-DDI-8964208",
"REACTOME:R-DME-209905",
"REACTOME:R-DME-8964208",
"REACTOME:R-HSA-209905",
"REACTOME:R-HSA-209931",
"REACTOME:R-HSA-2160456",
... | 20 | [
"1dmw",
"1j8t",
"1j8u",
"1kw0",
"1lrm",
"1ltu",
"1ltv",
"1ltz",
"1mlw",
"1mmk",
"1mmt",
"1pah",
"1phz",
"1tdw",
"1tg2",
"1toh",
"2pah",
"2phm",
"2toh",
"2v27",
"2v28",
"2xsn",
"3e2t",
"3hf6",
"3hf8",
"3hfb",
"3pah",
"3tcy",
"3tk2",
"3tk4",
"4anp",
"4bpt"... | 74 | [
"PUB00003948",
"PUB00003956",
"PUB00004466",
"PUB00004640"
] | [
"9228951",
"9406548",
"8594560",
"3475690"
] | [
"Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases.",
"Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria.",
"PAH Mutation Analysis Consortium Database: a database for diseas... | [
1997,
1997,
1996,
1987
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Mimiviridae sp. ChoanoV1",
"metagenomes"
] | [
4072,
7575,
1,
22
] | 4 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
6,
10,
9,
12,
7,
22
] | 6 | true | Binding_site | Aromatic amino acid hydroxylase, iron/copper binding site | Aromatic amino acid hydroxylase, iron/copper binding site | ArAA_hydroxylase_Fe/CU_BS | 9 |
IPR018302 | 18,302 | Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain | CenpF/LEK1_Rb-prot-bd | Domain | 1,025 | false | false | This entry represents the Rb protein-binding domain from the centromere protein Cenp-F. Cenp-F is a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, that is involved in chromosome segregation during mitosis and is essential for the full functioning of the mitotic check... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10490"
] | [
"CENP-F_C_Rb_bdg"
] | [
1025
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-141444",
"R-HSA-156711",
"R-HSA-2467813",
"R-HSA-2500257",
"R-HSA-5663220",
"R-HSA-68877",
"R-HSA-9648025"
] | [
"REACTOME:R-HSA-141444",
"REACTOME:R-HSA-156711",
"REACTOME:R-HSA-2467813",
"REACTOME:R-HSA-2500257",
"REACTOME:R-HSA-5663220",
"REACTOME:R-HSA-68877",
"REACTOME:R-HSA-9648025"
] | 7 | [] | 0 | [
"PUB00044189",
"PUB00044190",
"PUB00044455"
] | [
"7542657",
"14555653",
"17498689"
] | [
"CENP-F is a protein of the nuclear matrix that assembles onto kinetochores at late G2 and is rapidly degraded after mitosis.",
"LEK1 is a potential inhibitor of pocket protein-mediated cellular processes.",
"Conserved C-terminal domains of mCenp-F (LEK1) regulate subcellular localization and mitotic checkpoint... | [
1995,
2004,
2007
] | 3 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
1025
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
2,
5,
2
] | 4 | true | Domain | Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain | Kinetochore protein Cenp-F/LEK1, Rb protein-binding domain | CenpF/LEK1_Rb-prot-bd | 7 |
IPR018303 | 18,303 | P-type ATPase, phosphorylation site | ATPase_P-typ_P_site | PTM | 285,553 | false | false | This entry represents the several classes of P-type ATPases, including those that transport K + ( ), Mg 2+ ( ), Cd 2+ ( ), Cu 2+ ( ), Zn 2+ ( ), Na + ( ), Ca 2+ ( ), Na + /K + ( ), and H + /K + ( ). These P-ATPases are found in both prokaryotes and eukaryotes [ ]. They are cation transport ATPases which form an asparty... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00154"
] | [
"ATPASE_E1_E2"
] | [
285553
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
... | [
"7.2.2",
"R-BTA-418359",
"R-BTA-5578775",
"R-BTA-936837",
"R-CEL-418359",
"R-CEL-5578775",
"R-CEL-6798695",
"R-CEL-936837",
"R-CFA-418359",
"R-CFA-5578775",
"R-CFA-936837",
"R-DDI-418359",
"R-DDI-5578775",
"R-DDI-936837",
"R-DME-418359",
"R-DME-5578775",
"R-DME-936837",
"R-DRE-9368... | [
"EC:7.2.2",
"REACTOME:R-BTA-418359",
"REACTOME:R-BTA-5578775",
"REACTOME:R-BTA-936837",
"REACTOME:R-CEL-418359",
"REACTOME:R-CEL-5578775",
"REACTOME:R-CEL-6798695",
"REACTOME:R-CEL-936837",
"REACTOME:R-CFA-418359",
"REACTOME:R-CFA-5578775",
"REACTOME:R-CFA-936837",
"REACTOME:R-DDI-418359",
"... | 54 | [
"1iwo",
"1kju",
"1mhs",
"1su4",
"1t5s",
"1t5t",
"1vfp",
"1wpg",
"1xp5",
"2agv",
"2b8e",
"2by4",
"2c88",
"2c8k",
"2c8l",
"2c9m",
"2dqs",
"2ear",
"2eat",
"2eau",
"2iye",
"2o9j",
"2oa0",
"2voy",
"2xzb",
"2yfy",
"2yn9",
"2zbd",
"2zbe",
"2zbf",
"2zbg",
"2zxe"... | 405 | [
"PUB00003431"
] | [
"8151716"
] | [
"P-type ATPases of eukaryotes and bacteria: sequence analyses and construction of phylogenetic trees."
] | [
1994
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
4065,
129568,
150465,
23,
1432
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
223,
45,
196,
75,
4,
149,
126,
18,
127,
195,
16,
14,
461
] | 13 | true | PTM | P-type ATPase, phosphorylation site | P-type ATPase, phosphorylation site | ATPase_P-typ_P_site | 7 |
IPR018304 | 18,304 | Transcription regulator protein Rtt102 | Rtt102 | Family | 102 | false | false | Rtt102 (Regulator of Ty1 Transposition Protein 102) is a component of both the SWI/SNF and the RSC chromatin remodelling complexes [ ]. | [
"GO:0006338",
"GO:0005634",
"GO:0016514",
"GO:0016586"
] | [
"chromatin remodeling",
"nucleus",
"SWI/SNF complex",
"RSC-type complex"
] | [
"biological_process",
"cellular_component",
"cellular_component",
"cellular_component"
] | 4 | [
"PFAM"
] | [
"PF09510"
] | [
"Rtt102p"
] | [
102
] | 1 | [] | [] | [] | 0 | [
"4i6m",
"5tgc",
"6kw3",
"6kw4",
"6kw5",
"6tda",
"6uxw",
"6v92",
"6vz4",
"6vzg",
"7c4j",
"7egp"
] | 12 | [
"PUB00044479",
"PUB00063133",
"PUB00074623",
"PUB00074624"
] | [
"14660704",
"8980231",
"8816487",
"10466730"
] | [
"Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast.",
"RSC, an essential, abundant chromatin-remodeling complex.",
"Adenovirus E1A specifically blocks SWI/SNF-dependent transcriptional activation.",
"Nucleosome mobilization catalysed by the yeast SWI/SNF complex."
] | [
2004,
1996,
1996,
1999
] | 4 | [] | [] | 0 | 0 | null | [
"Saccharomycotina"
] | [
102
] | 1 | [
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1
] | 1 | true | Family | Transcription regulator protein Rtt102 | Transcription regulator protein Rtt102 | Rtt102 | 3 |
IPR018305 | 18,305 | Large ribosomal subunit protein mL50 | Ribosomal_m50 | Family | 2,548 | false | false | This entry represents the large ribosomal subunit protein mL50 from animals and fungi, previously known as L50 in humans [ ] and L13 in yeast [ , ]. | [
"GO:0005739"
] | [
"mitochondrion"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF10501",
"PTHR31542"
] | [
"Ribosomal_L50",
""
] | [
2360,
1337
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-5389840",
"R-BTA-5419276",
"R-BTA-9937383",
"R-HSA-5368286",
"R-HSA-5389840",
"R-HSA-5419276",
"R-HSA-9937383",
"R-MMU-5389840",
"R-MMU-5419276",
"R-MMU-9937383"
] | [
"REACTOME:R-BTA-5389840",
"REACTOME:R-BTA-5419276",
"REACTOME:R-BTA-9937383",
"REACTOME:R-HSA-5368286",
"REACTOME:R-HSA-5389840",
"REACTOME:R-HSA-5419276",
"REACTOME:R-HSA-9937383",
"REACTOME:R-MMU-5389840",
"REACTOME:R-MMU-5419276",
"REACTOME:R-MMU-9937383"
] | 10 | [
"3j6b",
"3j7y",
"3j9m",
"4v1a",
"5aj4",
"5mrc",
"5mre",
"5mrf",
"5ool",
"5oom",
"6gaw",
"6gb2",
"6i9r",
"6nu2",
"6nu3",
"6vlz",
"6vmi",
"6ydp",
"6ydw",
"6ywe",
"6yws",
"6ywv",
"6ywx",
"6ywy",
"6zm5",
"6zm6",
"6zs9",
"6zsa",
"6zsb",
"6zsc",
"6zsd",
"6zse"... | 99 | [
"PUB00004350",
"PUB00044461",
"PUB00044462",
"PUB00087081",
"PUB00089004",
"PUB00089007"
] | [
"3129699",
"8947311",
"15928344",
"24675956",
"25609543",
"25278503"
] | [
"RNA binding proteins of the large subunit of bovine mitochondrial ribosomes.",
"Differential effects of chronic ethanol consumption on hepatic mitochondrial and cytoplasmic ribosomes.",
"The pseudouridine synthase RluD is required for normal ribosome assembly and function in Escherichia coli.",
"Structure of... | [
1988,
1996,
2005,
2014,
2015,
2014
] | 6 | [] | [] | 0 | 0 | null | [
"Arcanobacterium hippocoleae",
"Eukaryota"
] | [
1,
2547
] | 2 | [
"Caenorhabditis elegans",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)"
] | [
1,
1,
1,
1,
1,
4,
1
] | 7 | true | Family | Large ribosomal subunit protein mL50 | Large ribosomal subunit protein mL50 | Ribosomal_m50 | 8 |
IPR018306 | 18,306 | Bacteriophage T5, Orf172 DNA-binding | Phage_T5_Orf172_DNA-bd | Domain | 11,558 | false | false | This entry represents a DNA-binding domain found in bacteriophage T5, ORF172 [ ]. The domain is related to the Bro-N and KilA-N domains that are widespread in large-DNA viruses infecting bacteria and eukaryotes [ ]. | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF10544",
"SM00974"
] | [
"T5orf172",
"T5orf172"
] | [
7314,
8491
] | 2 | [] | [] | [] | 0 | [] | 0 | [
"PUB00010111"
] | [
"11897024"
] | [
"Extensive domain shuffling in transcription regulators of DNA viruses and implications for the origin of fungal APSES transcription factors."
] | [
2002
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
26,
6161,
4503,
619,
249
] | 5 | [
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
1,
1
] | 2 | true | Domain | Bacteriophage T5, Orf172 DNA-binding | Bacteriophage T5, Orf172 DNA-binding | Phage_T5_Orf172_DNA-bd | 6 |
IPR018307 | 18,307 | AVL9/DENND6 domain | ABL9/DENND6_dom | Domain | 5,685 | false | false | This domain is found in late secretory protein Avl9, which is required for the generation of secretory vesicles as well as for actin polarization and polarized growth. It is also found in DENND6 proteins, which act as guanine nucleotide exchange factors (GEF) for RAB14 [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF09794"
] | [
"Avl9"
] | [
5685
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DDI-8876198",
"R-HSA-8876198",
"R-MMU-8876198"
] | [
"REACTOME:R-DDI-8876198",
"REACTOME:R-HSA-8876198",
"REACTOME:R-MMU-8876198"
] | 3 | [] | 0 | [
"PUB00066797"
] | [
"22595670"
] | [
"Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells."
] | [
2012
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5685
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strai... | [
2,
9,
5,
5,
3,
1,
14,
1,
1
] | 9 | true | Domain | AVL9/DENND6 domain | AVL9/DENND6 domain | ABL9/DENND6_dom | 9 |
IPR018309 | 18,309 | Transcription regulator PadR, C-terminal | Tscrpt_reg_PadR_C | Domain | 11,917 | false | false | Phenolic acids, also called substituted hydroxycinnamic acids, are abundant in the plant kingdom because they are involved in the structure of plant cell walls and are present in some vacuoles. In plant-soil ecosystems they are released as free acids by hemicellulases produced by several fungi and bacteria. Of these we... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10400"
] | [
"Vir_act_alpha_C"
] | [
11917
] | 1 | [] | [] | [] | 0 | [
"1yg2",
"3l9f",
"5x11",
"5x12",
"5x13",
"5x14",
"5y8t",
"7cbv",
"8ioi"
] | 9 | [
"PUB00014956"
] | [
"15066807"
] | [
"Cloning, deletion, and characterization of PadR, the transcriptional repressor of the phenolic acid decarboxylase-encoding padA gene of Lactobacillus plantarum."
] | [
2004
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Methanobacteriota",
"Psathyrellaceae",
"unclassified sequences"
] | [
11841,
7,
2,
67
] | 4 | [] | [] | 0 | true | Domain | Transcription regulator PadR, C-terminal | Transcription regulator PadR, C-terminal | Tscrpt_reg_PadR_C | 4 |
IPR018310 | 18,310 | Putative endonuclease, Z1 domain | Put_endonuclease_Z1-dom | Domain | 2,394 | false | false | This entry represents the Z1 domain of unknown function that is found in a group of putative endonucleases. This domain is found associated with a helicase domain of superfamily type II [ ]. | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF10593"
] | [
"Z1"
] | [
2394
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00044141"
] | [
"18346280"
] | [
"MutL homologs in restriction-modification systems and the origin of eukaryotic MORC ATPases."
] | [
2008
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Myoviridae sp. ctool15",
"unclassified sequences"
] | [
2344,
4,
12,
1,
33
] | 5 | [] | [] | 0 | true | Domain | Putative endonuclease, Z1 domain | Putative endonuclease, Z1 domain | Put_endonuclease_Z1-dom | 7 |
IPR018311 | 18,311 | Autoinducer synthesis, conserved site | Autoind_synth_CS | Conserved_site | 2,588 | false | false | Bacterial species have many methods of controlling gene expression and cell growth. Regulation of gene expression in response to changes in cell density is termed quorum sensing [ , ]. Quorum-sensing bacteria produce, release and respond to hormone-like molecules (autoinducers) that accumulate in the external environme... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00949"
] | [
"AUTOINDUCER_SYNTH_1"
] | [
2588
] | 1 | [
"EC",
"METACYC"
] | [
"2.3.1.184",
"PWY-6157"
] | [
"EC:2.3.1.184",
"METACYC:PWY-6157"
] | 2 | [
"1k4j",
"1kzf",
"1ro5",
"3p2f",
"3p2h"
] | 5 | [
"PUB00003852",
"PUB00007153",
"PUB00007154",
"PUB00007155",
"PUB00007156"
] | [
"7968529",
"10607620",
"9990077",
"8188582",
"3697093"
] | [
"A novel strategy for the isolation of luxI homologues: evidence for the widespread distribution of a LuxR:LuxI superfamily in enteric bacteria.",
"How bacteria talk to each other: regulation of gene expression by quorum sensing.",
"Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi:... | [
1993,
1999,
1999,
1994,
1987
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Thecamonas trahens ATCC 50062",
"unclassified sequences"
] | [
2571,
1,
16
] | 3 | [] | [] | 0 | true | Conserved_site | Autoinducer synthesis, conserved site | Autoinducer synthesis, conserved site | Autoind_synth_CS | 2 |
IPR018313 | 18,313 | Solute-binding protein family 3, conserved site | SBP_3_CS | Conserved_site | 49,733 | false | false | Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-bi... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS01039"
] | [
"SBP_BACTERIAL_3"
] | [
49733
] | 1 | [] | [] | [] | 0 | [
"1ggg",
"1hpb",
"1hsl",
"1laf",
"1lag",
"1lah",
"1lst",
"1wdn",
"2iee",
"2lao",
"2m8c",
"2v25",
"2y7i",
"2yjp",
"2yln",
"3k4u",
"3kbr",
"3vv5",
"3vvd",
"3vve",
"3vvf",
"3zsf",
"4kpt",
"4la9",
"4p0i",
"4pow",
"4pp0",
"4ymx",
"4zv1",
"4zv2",
"5hpq",
"5ito"... | 79 | [
"PUB00003610",
"PUB00071925",
"PUB00071938"
] | [
"8336670",
"18310026",
"8003968"
] | [
"Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria.",
"Characterization of a Pseudomonas putida ABC transporter (AatJMQP) required for acidic amino acid uptake: biochemical properties and regulation by the Aau two-component system.",
"Sequence relati... | [
1993,
2008,
1994
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
206,
49133,
149,
2,
243
] | 5 | [
"Escherichia coli (strain K12)"
] | [
7
] | 1 | true | Conserved_site | Solute-binding protein family 3, conserved site | Solute-binding protein family 3, conserved site | SBP_3_CS | 6 |
IPR018316 | 18,316 | Tubulin/FtsZ, 2-layer sandwich domain | Tubulin/FtsZ_2-layer-sand-dom | Domain | 94,029 | false | false | This domain is found in the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. These proteins are GTPases and are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring... | [] | [] | [] | 0 | [
"PFAM",
"SMART"
] | [
"PF03953",
"SM00865"
] | [
"Tubulin_C",
"Tubulin_C"
] | [
62572,
89382
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-114608",
"R-BTA-190840",
"R-BTA-2132295",
"R-BTA-2467813",
"R-BTA-2500257",
"R-BTA-2565942",
"R-BTA-3371497",
"R-BTA-380259",
"R-BTA-380270",
"R-BTA-380284",
"R-BTA-380320",
"R-BTA-5610787",
"R-BTA-5617833",
"R-BTA-5620912",
"R-BTA-5620924",
"R-BTA-5626467",
"R-BTA-5663220",
... | [
"REACTOME:R-BTA-114608",
"REACTOME:R-BTA-190840",
"REACTOME:R-BTA-2132295",
"REACTOME:R-BTA-2467813",
"REACTOME:R-BTA-2500257",
"REACTOME:R-BTA-2565942",
"REACTOME:R-BTA-3371497",
"REACTOME:R-BTA-380259",
"REACTOME:R-BTA-380270",
"REACTOME:R-BTA-380284",
"REACTOME:R-BTA-380320",
"REACTOME:R-BT... | 233 | [
"1ffx",
"1fsz",
"1ia0",
"1jff",
"1ofu",
"1rlu",
"1rq2",
"1rq7",
"1sa0",
"1sa1",
"1tub",
"1tvk",
"1w58",
"1w59",
"1w5a",
"1w5b",
"1w5e",
"1w5f",
"1z2b",
"1z5v",
"1z5w",
"2bto",
"2btq",
"2hxf",
"2hxh",
"2p4n",
"2q1x",
"2q1y",
"2r6r",
"2r75",
"2rhh",
"2rhj"... | 880 | [] | [] | [] | [] | 0 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"unclassified sequences"
] | [
1420,
26865,
65135,
1,
608
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
58,
19,
33,
30,
1,
92,
37,
4,
43,
64,
4,
4,
146
] | 13 | true | Domain | Tubulin/FtsZ, 2-layer sandwich domain | Tubulin/FtsZ, 2-layer sandwich domain | Tubulin/FtsZ_2-layer-sand-dom | 2 |
IPR018317 | 18,317 | Queuosine biosynthesis protein QueC | QueC | Family | 17,230 | false | false | This family represents Queuosine biosynthesis protein (QueC), also known as 7-cyano-7-deazaguanine synthas, which catalyses the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0) [ , , ]. | [] | [] | [] | 0 | [
"HAMAP",
"PFAM",
"PIRSF",
"PANTHER",
"NCBIFAM",
"CDD"
] | [
"MF_01633",
"PF06508",
"PIRSF006293",
"PTHR42914",
"TIGR00364",
"cd01995"
] | [
"QueC",
"QueC",
"ExsB",
"",
"",
"QueC-like"
] | [
14550,
17219,
14798,
16027,
14610,
14930
] | 6 | [
"EC",
"GP",
"METACYC"
] | [
"6.3.4.20",
"GenProp1602",
"PWY-6703"
] | [
"EC:6.3.4.20",
"GP:GenProp1602",
"METACYC:PWY-6703"
] | 3 | [
"2pg3",
"3bl5",
"9nto"
] | 3 | [
"PUB00050678",
"PUB00056809",
"PUB00056816"
] | [
"18491386",
"16199558",
"19354300"
] | [
"Crystal structure of QueC from Bacillus subtilis: an enzyme involved in preQ1 biosynthesis.",
"Genetic analysis identifies a function for the queC (ybaX) gene product at an initial step in the queuosine biosynthetic pathway in Escherichia coli.",
"The deazapurine biosynthetic pathway revealed: in vitro enzymat... | [
2008,
2005,
2009
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
1128,
15276,
238,
152,
436
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Queuosine biosynthesis protein QueC | Queuosine biosynthesis protein QueC | QueC | 3 |
IPR018320 | 18,320 | DNA polymerase 1 | DNA_polymerase_1 | Family | 25,797 | false | false | DNA carries the biological information that instructs cells how to exist in an ordered fashion. Accurate replication is thus one of the most important events in the cell life cycle. This function is mediated by DNA-directed DNA polymerases, which add nucleotide triphosphate (dNTP) residues to the 3'-end of the growing ... | [
"GO:0003887",
"GO:0006260"
] | [
"DNA-directed DNA polymerase activity",
"DNA replication"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR00593"
] | [
"pola"
] | [
25797
] | 1 | [
"EC"
] | [
"2.7.7.7"
] | [
"EC:2.7.7.7"
] | 1 | [
"1bgx",
"1d8y",
"1d9d",
"1d9f",
"1dpi",
"1jxe",
"1kfd",
"1kfs",
"1kln",
"1krp",
"1ksp",
"1ktq",
"1l3s",
"1l3t",
"1l3u",
"1l3v",
"1l5u",
"1lv5",
"1njw",
"1njx",
"1njy",
"1njz",
"1nk0",
"1nk4",
"1nk5",
"1nk6",
"1nk7",
"1nk8",
"1nk9",
"1nkb",
"1nkc",
"1nke"... | 230 | [
"PUB00004647",
"PUB00004955"
] | [
"3479792",
"2196557"
] | [
"Bacteriophage PRD1 DNA polymerase: evolution of DNA polymerases.",
"An attempt to unify the structure of polymerases."
] | [
1987,
1990
] | 2 | [
"IPR002298"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"Methanomethylophilus alvi",
"unclassified Caudoviricetes",
"unclassified sequences"
] | [
25325,
43,
2,
2,
425
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | DNA polymerase 1 | DNA polymerase 1 | DNA_polymerase_1 | 6 |
IPR018321 | 18,321 | Glucosamine-6-phosphate isomerase, conserved site | Glucosamine6P_isomerase_CS | Conserved_site | 16,676 | false | false | Glucosamine-6-phosphate isomerase ( ) catalyses the conversion of D-glucosamine 6-phosphate (GlcN6P) to D-fructose 6-phosphate and ammonia. This is the last step in the pathway for N-acetylglucosamine (GlcNAC) utilization in bacteria such as Escherichia coli (gene nagB) or in fungi such as Candida albicans (Yeast) (gen... | [
"GO:0004342",
"GO:0006044"
] | [
"glucosamine-6-phosphate deaminase activity",
"N-acetylglucosamine metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROSITE"
] | [
"PS01161"
] | [
"GLC_GALNAC_ISOMERASE"
] | [
16676
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.5.99.6",
"PWY-5514",
"PWY-6855",
"PWY-6906",
"R-BTA-70171",
"R-CEL-70171",
"R-DDI-70171",
"R-DME-70171",
"R-HSA-70171",
"R-MMU-70171",
"R-XTR-70171"
] | [
"EC:3.5.99.6",
"METACYC:PWY-5514",
"METACYC:PWY-6855",
"METACYC:PWY-6906",
"REACTOME:R-BTA-70171",
"REACTOME:R-CEL-70171",
"REACTOME:R-DDI-70171",
"REACTOME:R-DME-70171",
"REACTOME:R-HSA-70171",
"REACTOME:R-MMU-70171",
"REACTOME:R-XTR-70171"
] | 11 | [
"1cd5",
"1dea",
"1fqo",
"1frz",
"1fs5",
"1fs6",
"1fsf",
"1hor",
"1hot",
"1jt9",
"1ne7",
"2bkv",
"2bkx",
"2wu1",
"3hn6",
"4r7t",
"5hj5",
"6nbg",
"7lqm",
"7lqn"
] | 20 | [
"PUB00005253",
"PUB00044804"
] | [
"8747459",
"18436239"
] | [
"Structure and catalytic mechanism of glucosamine 6-phosphate deaminase from Escherichia coli at 2.1 A resolution.",
"Ring-opening mechanism revealed by crystal structures of NagB and its ES intermediate complex."
] | [
1995,
2008
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Marseillevirus LCMAC201",
"unclassified sequences"
] | [
2,
11556,
4996,
1,
121
] | 5 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Rattus norvegicus"
] | [
1,
3,
3,
3,
8,
6,
1,
5
] | 8 | true | Conserved_site | Glucosamine-6-phosphate isomerase, conserved site | Glucosamine-6-phosphate isomerase, conserved site | Glucosamine6P_isomerase_CS | 3 |
IPR018323 | 18,323 | Outer membrane lipoprotein carrier protein LolA, Proteobacteria | OM_lipoprot_carrier_LolA_Pbac | Family | 6,589 | false | false | In Escherichia coli, lipoproteins are anchored to the periplasmic side of either the inner or outer membrane through N-terminal lipids, depending on the lipoprotein-sorting signal present at position 2 [ ]. Five Lol proteins are involved in the sorting and outer membrane localization of lipoproteins. LolCDE, an ATP bin... | [
"GO:0042953",
"GO:0042597"
] | [
"lipoprotein transport",
"periplasmic space"
] | [
"biological_process",
"cellular_component"
] | 2 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00240",
"TIGR00547"
] | [
"LolA",
"lolA"
] | [
6358,
6080
] | 2 | [
"GP"
] | [
"GenProp0207"
] | [
"GP:GenProp0207"
] | 1 | [
"1iwl",
"1ua8",
"2w7q",
"2zpc",
"2zpd",
"3ksn",
"4ki3",
"6f3z",
"6fhm",
"7arm",
"7z6w",
"7z6x",
"8chx",
"8orn",
"8v1k"
] | 15 | [
"PUB00007680",
"PUB00061670",
"PUB00061671",
"PUB00061675"
] | [
"12032293",
"19716823",
"20620146",
"20419407"
] | [
"Elucidation of the function of lipoprotein-sorting signals that determine membrane localization.",
"Real time analysis of lipoprotein transfer from LolA to LolB by means of surface plasmon resonance.",
"Hydrophobic surface patches on LolA of Pseudomonas aeruginosa are essential for lipoprotein binding.",
"So... | [
2002,
2009,
2010,
2010
] | 4 | [
"IPR004564"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
6495,
12,
82
] | 3 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Outer membrane lipoprotein carrier protein LolA, Proteobacteria | Outer membrane lipoprotein carrier protein LolA, Proteobacteria | OM_lipoprot_carrier_LolA_Pbac | 1 |
IPR018324 | 18,324 | Checkpoint protein Rad17/Rad24, fungi/metazoa | Rad17/Rad24_fun/met | Family | 934 | false | false | This entry consists of the checkpoint protein Rad24 from budding yeast and its homologue, Rad17, from other organisms. This entry does not include Rad17 from plants. In Saccharomyces cerevisiae, Rad24 forms a complex with replication factor C (RFC) proteins, including Rfc2, Rfc3, Rfc4, and Rfc5. When DNA damage is dete... | [
"GO:0003689",
"GO:0000077",
"GO:0006281",
"GO:0005634",
"GO:0031389"
] | [
"DNA clamp loader activity",
"DNA damage checkpoint signaling",
"DNA repair",
"nucleus",
"Rad17 RFC-like complex"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component",
"cellular_component"
] | 5 | [
"NCBIFAM"
] | [
"TIGR00602"
] | [
"rad24"
] | [
934
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-176187",
"R-HSA-5685938",
"R-HSA-5693607",
"R-HSA-5693616",
"R-HSA-6804756",
"R-HSA-69473",
"R-HSA-9709570",
"R-MMU-176187",
"R-MMU-5685938",
"R-MMU-5693607",
"R-MMU-6804756",
"R-MMU-69473",
"R-SCE-176187",
"R-SPO-176187"
] | [
"REACTOME:R-HSA-176187",
"REACTOME:R-HSA-5685938",
"REACTOME:R-HSA-5693607",
"REACTOME:R-HSA-5693616",
"REACTOME:R-HSA-6804756",
"REACTOME:R-HSA-69473",
"REACTOME:R-HSA-9709570",
"REACTOME:R-MMU-176187",
"REACTOME:R-MMU-5685938",
"REACTOME:R-MMU-5693607",
"REACTOME:R-MMU-6804756",
"REACTOME:R-... | 14 | [
"7sgz",
"7sh2",
"7st9",
"7stb",
"7ste",
"7z6h",
"8dqw",
"8fs3",
"8fs4",
"8fs5",
"8fs6",
"8fs7",
"8fs8"
] | 13 | [
"PUB00059229",
"PUB00062362",
"PUB00062364",
"PUB00062365",
"PUB00062366",
"PUB00062367",
"PUB00062368",
"PUB00062369",
"PUB00062370"
] | [
"12604797",
"15297881",
"10511543",
"12944484",
"11267834",
"10675560",
"15454530",
"10232579",
"11555598"
] | [
"Yeast Rad17/Mec3/Ddc1: a sliding clamp for the DNA damage checkpoint.",
"Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination.",
"Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partn... | [
2003,
2004,
1999,
2003,
2001,
2000,
2004,
1999,
2001
] | 9 | [
"IPR004582"
] | [] | 1 | 0 | 1 | [
"Opisthokonta"
] | [
934
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)"
] | [
2,
4,
2,
3,
1,
1
] | 6 | true | Family | Checkpoint protein Rad17/Rad24, fungi/metazoa | Checkpoint protein Rad17/Rad24, fungi/metazoa | Rad17/Rad24_fun/met | 5 |
IPR018325 | 18,325 | Rad4/PNGase transglutaminase-like fold | Rad4/PNGase_transGLS-fold | Domain | 5,554 | false | false | RAD4/Xp-C proteins contain an ancient transglutaminase fold that is also found in peptide-N-glycanases (PNGases), which remove glycans from glycoproteins during their degradation. The PNGases retain the catalytic triad that is typical of this fold and are predicted to have a reaction mechanism similar to that involved ... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03835"
] | [
"Rad4"
] | [
5554
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-5696394",
"R-DME-5696395",
"R-HSA-3108214",
"R-HSA-5696394",
"R-HSA-5696395",
"R-MMU-3108214",
"R-MMU-5696394",
"R-MMU-5696395",
"R-SPO-3108214",
"R-SPO-5696395"
] | [
"REACTOME:R-DME-5696394",
"REACTOME:R-DME-5696395",
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-5696394",
"REACTOME:R-HSA-5696395",
"REACTOME:R-MMU-3108214",
"REACTOME:R-MMU-5696394",
"REACTOME:R-MMU-5696395",
"REACTOME:R-SPO-3108214",
"REACTOME:R-SPO-5696395"
] | 10 | [
"2qsf",
"2qsg",
"2qsh",
"4yir",
"6cfi",
"6ubf",
"6ug1",
"6uin",
"7k04",
"7m2u",
"8ebs",
"8ebu",
"8ebv",
"8ebw",
"8ebx",
"8eby"
] | 16 | [
"PUB00044805"
] | [
"11487565"
] | [
"Peptide-N-glycanases and DNA repair proteins, Xp-C/Rad4, are, respectively, active and inactivated enzymes sharing a common transglutaminase fold."
] | [
2001
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5554
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
2,
1,
12,
3,
2,
3,
2,
1,
2,
8
] | 12 | true | Domain | Rad4/PNGase transglutaminase-like fold | Rad4/PNGase transglutaminase-like fold | Rad4/PNGase_transGLS-fold | 7 |
IPR018326 | 18,326 | Rad4 beta-hairpin domain 1 | Rad4_beta-hairpin_dom1 | Domain | 5,955 | false | false | This short domain is found in the Rad4 protein. This domain binds to DNA [ ]. | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF10403",
"SM01030"
] | [
"BHD_1",
"BHD_1"
] | [
5931,
5938
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-5696394",
"R-DME-5696395",
"R-HSA-3108214",
"R-HSA-5696394",
"R-HSA-5696395",
"R-MMU-3108214",
"R-MMU-5696394",
"R-MMU-5696395",
"R-SCE-3108214",
"R-SPO-3108214",
"R-SPO-5696395"
] | [
"REACTOME:R-DME-5696394",
"REACTOME:R-DME-5696395",
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-5696394",
"REACTOME:R-HSA-5696395",
"REACTOME:R-MMU-3108214",
"REACTOME:R-MMU-5696394",
"REACTOME:R-MMU-5696395",
"REACTOME:R-SCE-3108214",
"REACTOME:R-SPO-3108214",
"REACTOME:R-SPO-5696395"
] | 11 | [
"2qsf",
"2qsg",
"2qsh",
"4yir",
"6cfi",
"6ubf",
"6ug1",
"6uin",
"7k04",
"7m2u",
"8ebs",
"8ebt",
"8ebu",
"8ebv",
"8ebw",
"8ebx",
"8eby"
] | 17 | [
"PUB00044171"
] | [
"17882165"
] | [
"Recognition of DNA damage by the Rad4 nucleotide excision repair protein."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
5955
] | 1 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
6,
1,
2,
1,
8,
3,
2,
3,
2,
2,
2,
3
] | 12 | true | Domain | Rad4 beta-hairpin domain 1 | Rad4 beta-hairpin domain 1 | Rad4_beta-hairpin_dom1 | 1 |
IPR018327 | 18,327 | Rad4 beta-hairpin domain 2 | BHD_2 | Domain | 5,658 | false | false | This short domain is found in the Rad4 protein. This domain binds to DNA [ ]. | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF10404",
"SM01031"
] | [
"BHD_2",
"BHD_2"
] | [
5074,
5525
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-5696394",
"R-DME-5696395",
"R-HSA-3108214",
"R-HSA-5696394",
"R-HSA-5696395",
"R-MMU-3108214",
"R-MMU-5696394",
"R-MMU-5696395",
"R-SCE-3108214",
"R-SPO-3108214",
"R-SPO-5696395"
] | [
"REACTOME:R-DME-5696394",
"REACTOME:R-DME-5696395",
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-5696394",
"REACTOME:R-HSA-5696395",
"REACTOME:R-MMU-3108214",
"REACTOME:R-MMU-5696394",
"REACTOME:R-MMU-5696395",
"REACTOME:R-SCE-3108214",
"REACTOME:R-SPO-3108214",
"REACTOME:R-SPO-5696395"
] | 11 | [
"2qsf",
"2qsg",
"2qsh",
"4yir",
"6cfi",
"6ubf",
"6ug1",
"6uin",
"7k04",
"7m2u",
"8ebs",
"8ebt",
"8ebu",
"8ebv",
"8ebw",
"8ebx",
"8eby"
] | 17 | [
"PUB00044171"
] | [
"17882165"
] | [
"Recognition of DNA damage by the Rad4 nucleotide excision repair protein."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Magnetococcus massalia (strain MO-1)"
] | [
5657,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
2,
1,
8,
2,
2,
3,
2,
2,
2,
3
] | 12 | true | Domain | Rad4 beta-hairpin domain 2 | Rad4 beta-hairpin domain 2 | BHD_2 | 7 |
IPR018328 | 18,328 | Rad4 beta-hairpin domain 3 | Rad4_beta-hairpin_dom3 | Domain | 5,882 | false | false | This short domain is found in the Rad4 protein. This domain binds to DNA [ ]. | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"SMART"
] | [
"PF10405",
"SM01032"
] | [
"BHD_3",
"BHD_3"
] | [
5873,
5800
] | 2 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DME-5696394",
"R-DME-5696395",
"R-HSA-3108214",
"R-HSA-5696394",
"R-HSA-5696395",
"R-MMU-3108214",
"R-MMU-5696394",
"R-MMU-5696395",
"R-SCE-3108214",
"R-SPO-3108214",
"R-SPO-5696395"
] | [
"REACTOME:R-DME-5696394",
"REACTOME:R-DME-5696395",
"REACTOME:R-HSA-3108214",
"REACTOME:R-HSA-5696394",
"REACTOME:R-HSA-5696395",
"REACTOME:R-MMU-3108214",
"REACTOME:R-MMU-5696394",
"REACTOME:R-MMU-5696395",
"REACTOME:R-SCE-3108214",
"REACTOME:R-SPO-3108214",
"REACTOME:R-SPO-5696395"
] | 11 | [
"2qsf",
"2qsg",
"2qsh",
"4yir",
"6cfi",
"6ubf",
"6ug1",
"6uin",
"7k04",
"7m2u",
"8ebs",
"8ebt",
"8ebu",
"8ebv",
"8ebw",
"8ebx",
"8eby"
] | 17 | [
"PUB00044171"
] | [
"17882165"
] | [
"Recognition of DNA damage by the Rad4 nucleotide excision repair protein."
] | [
2007
] | 1 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Gimesia benthica"
] | [
5881,
1
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
5,
1,
2,
1,
6,
2,
2,
3,
2,
2,
2,
3
] | 12 | true | Domain | Rad4 beta-hairpin domain 3 | Rad4 beta-hairpin domain 3 | Rad4_beta-hairpin_dom3 | 9 |
IPR018330 | 18,330 | RecT family | RecT_fam | Family | 7,247 | false | false | The DNA single-strand annealing proteins (SSAPs), such as RecT, Red-beta, ERF and Rad52, function in RecA-dependent and RecA-independent DNA recombination pathways [ ]. This family includes RecT and related proteins. | [
"GO:0003677",
"GO:0006259"
] | [
"DNA binding",
"DNA metabolic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PFAM"
] | [
"PF03837"
] | [
"RecT"
] | [
7247
] | 1 | [] | [] | [] | 0 | [
"7ub2",
"7ubb",
"7ujl"
] | 3 | [
"PUB00009986"
] | [
"11914131"
] | [
"Classification and evolutionary history of the single-strand annealing proteins, RecT, Redbeta, ERF and RAD52."
] | [
2002
] | 1 | [] | [
"IPR004590",
"IPR010183"
] | 0 | 2 | 0 | [
"Bacteria",
"Eukaryota",
"Methanomicrobia",
"Viruses",
"unclassified sequences"
] | [
6305,
15,
5,
705,
217
] | 5 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | RecT family | RecT family | RecT_fam | 3 |
IPR018332 | 18,332 | Antenna complex, alpha subunit | Antenna_alpha | Family | 1,188 | false | false | The antenna complexes of photosynthetic bacteria function as light-harvesting systems that absorb light and transfer the excitation energy to the reaction centres. The antenna complexes usually comprise 2 polypeptides (alpha- and beta-chains), 2-3 bacteriochlorophyll molecules and some carotenoids [ , , , ]. The alpha-... | [] | [] | [] | 0 | [
"NCBIFAM",
"PRINTS"
] | [
"NF040861",
"PR00673"
] | [
"pufA_517_ASD",
"LIGHTHARVSTA"
] | [
978,
956
] | 2 | [] | [] | [] | 0 | [
"1ijd",
"1kzu",
"1lgh",
"1nkz",
"1xrd",
"2fkw",
"3wmm",
"4v8k",
"4v9g",
"5b5m",
"5b5n",
"5y5s",
"6et5",
"6q53",
"6z5r",
"6z5s",
"6zxa",
"7c52",
"7c9r",
"7ddq",
"7eqd",
"7f0l",
"7o0u",
"7o0v",
"7o0w",
"7o0x",
"7oy8",
"7pbw",
"7pil",
"7pqd",
"7tuw",
"7tv3"... | 81 | [
"PUB00001417",
"PUB00003468",
"PUB00153105",
"PUB00153106"
] | [
"1577009",
"1460542",
"36738736",
"36792596"
] | [
"The primary structure of the antenna polypeptides of Ectothiorhodospira halochloris and Ectothiorhodospira halophila. Four core-type antenna polypeptides in E. halochloris and E. halophila.",
"Structure, function and organization of antenna polypeptides and antenna complexes from the three families of Rhodospiri... | [
1992,
1992,
2023,
2023
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Hemiselmis andersenii",
"freshwater sediment metagenome"
] | [
1186,
1,
1
] | 3 | [] | [] | 0 | true | Family | Antenna complex, alpha subunit | Antenna complex, alpha subunit | Antenna_alpha | 3 |
IPR018333 | 18,333 | Squalene cyclase | Squalene_cyclase | Family | 17,667 | false | false | Several enzymes catalyse mechanistically related reactions which involve the highly complex cyclic rearrangement of squalene or its 2,3 oxide. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyse a cationic cyclisation cascade converting linear triterpenes to fused ... | [
"GO:0016866",
"GO:0016104",
"GO:0005811"
] | [
"intramolecular transferase activity",
"triterpenoid biosynthetic process",
"lipid droplet"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"PANTHER",
"SFLD",
"NCBIFAM",
"CDD"
] | [
"PTHR11764",
"SFLDG01016",
"TIGR01787",
"cd02892"
] | [
"",
"Prenyltransferase_Like_2",
"squalene_cyclas",
"SQCY_1"
] | [
17644,
11160,
13496,
11428
] | 4 | [
"EC",
"GP",
"GP",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.4.99",
"GenProp0724",
"GenProp1594",
"R-DDI-191273",
"R-HSA-191273",
"R-HSA-2426168",
"R-MMU-191273",
"R-RNO-191273",
"R-SCE-191273",
"R-SPO-191273"
] | [
"EC:5.4.99",
"GP:GenProp0724",
"GP:GenProp1594",
"REACTOME:R-DDI-191273",
"REACTOME:R-HSA-191273",
"REACTOME:R-HSA-2426168",
"REACTOME:R-MMU-191273",
"REACTOME:R-RNO-191273",
"REACTOME:R-SCE-191273",
"REACTOME:R-SPO-191273"
] | 10 | [
"1gsz",
"1h35",
"1h36",
"1h37",
"1h39",
"1h3a",
"1h3b",
"1h3c",
"1o6h",
"1o6q",
"1o6r",
"1o79",
"1sqc",
"1ump",
"1w6j",
"1w6k",
"2sqc",
"3sqc",
"8j5z"
] | 19 | [
"PUB00004809",
"PUB00005227",
"PUB00023140",
"PUB00080774",
"PUB00080775",
"PUB00080779",
"PUB00080784",
"PUB00097904"
] | [
"7505443",
"9295270",
"9931258",
"9519404",
"11027983",
"15593147",
"2253626",
"30977375"
] | [
"Isolation of an Arabidopsis thaliana gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screen.",
"Structure and function of a squalene cyclase.",
"The structure of the membrane protein squalene-hopene cyclase at 2.0 A reso... | [
1993,
1997,
1999,
1998,
2000,
2004,
1990,
2019
] | 8 | [] | [
"IPR006400",
"IPR016731",
"IPR017826"
] | 0 | 3 | 0 | [
"Bacteria",
"Eukaryota",
"Stenosarchaea group",
"unclassified sequences"
] | [
4761,
12758,
15,
133
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (st... | [
84,
1,
6,
1,
1,
56,
4,
1,
1,
97
] | 10 | true | Family | Squalene cyclase | Squalene cyclase | Squalene_cyclase | 8 |
IPR018334 | 18,334 | ArsR-type transcription regulator, HTH motif | ArsR_HTH | Conserved_site | 10,581 | false | false | Bacterial transcription regulatory proteins that bind DNA via a helix-turn-helix (HTH) motif can be grouped into families on the basis of sequence similarities. One such group, termed arsR, includes several proteins that appear to dissociate from DNA in the presence of metal ions: arsR, which functions as a transcripti... | [
"GO:0003700",
"GO:0006355"
] | [
"DNA-binding transcription factor activity",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROSITE"
] | [
"PS00846"
] | [
"HTH_ARSR_1"
] | [
10581
] | 1 | [] | [] | [] | 0 | [
"1r1t",
"1r23",
"1smt",
"1u2w",
"3f72"
] | 5 | [
"PUB00004420",
"PUB00004445",
"PUB00057829"
] | [
"8506147",
"8451191",
"7543476"
] | [
"A possible mechanism for metal-ion induced DNA-protein dissociation in a family of prokaryotic transcriptional regulators.",
"SmtB is a metal-dependent repressor of the cyanobacterial metallothionein gene smtA: identification of a Zn inhibited DNA-protein complex.",
"CadC, the transcriptional regulatory protei... | [
1993,
1993,
1995
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
52,
10401,
8,
120
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Conserved_site | ArsR-type transcription regulator, HTH motif | ArsR-type transcription regulator, HTH motif | ArsR_HTH | 5 |
IPR018336 | 18,336 | Ribonuclease PH, conserved site | RNase_PH_CS | Conserved_site | 16,981 | false | false | Prokaryotic ribonuclease PH ( ) (RNase PH) is a phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates [ ]. There is a similar protein in Caenorhabditis elegans that belongs to t... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS01277"
] | [
"RIBONUCLEASE_PH"
] | [
16981
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.7.7.56",
"R-CEL-429958",
"R-CEL-450385",
"R-CEL-450513",
"R-CEL-6791226",
"R-CEL-9930044"
] | [
"EC:2.7.7.56",
"REACTOME:R-CEL-429958",
"REACTOME:R-CEL-450385",
"REACTOME:R-CEL-450513",
"REACTOME:R-CEL-6791226",
"REACTOME:R-CEL-9930044"
] | 6 | [
"1oyp",
"1oyr",
"1oys",
"1r6l",
"1r6m",
"1udn",
"1udo",
"1udq",
"1uds",
"3b4t",
"3dd6"
] | 11 | [
"PUB00002736"
] | [
"1512253"
] | [
"Characterization of Escherichia coli RNase PH."
] | [
1992
] | 1 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Myoviridae sp. ct2798",
"unclassified sequences"
] | [
45,
16485,
74,
1,
376
] | 5 | [
"Caenorhabditis elegans",
"Escherichia coli (strain K12)"
] | [
1,
1
] | 2 | true | Conserved_site | Ribonuclease PH, conserved site | Ribonuclease PH, conserved site | RNase_PH_CS | 3 |
IPR018337 | 18,337 | Cell wall/choline-binding repeat | Cell_wall/Cho-bd_repeat | Repeat | 13,966 | false | false | The cell wall-binding repeat (CW) is an about 20 amino acid residue module, essentially found in two bacterial Gram-positive protein families; the choline binding proteins and glucosyltransferases ( ). In choline-binding proteins cell wall binding repeats bind to choline moieties of both teichoic and lipoteichoic acids... | [] | [] | [] | 0 | [
"PFAM",
"PFAM",
"PFAM",
"PROFILE"
] | [
"PF01473",
"PF19085",
"PF19127",
"PS51170"
] | [
"Choline_bind_1",
"Choline_bind_2",
"Choline_bind_3",
"CW"
] | [
9915,
2194,
10859,
11986
] | 4 | [
"EC"
] | [
"2.4.1"
] | [
"EC:2.4.1"
] | 1 | [
"1gvm",
"1h09",
"1h8g",
"1hcx",
"1oba",
"2bib",
"2bml",
"2f6e",
"2g7c",
"2ixu",
"2ixv",
"2j8f",
"2j8g",
"2qj6",
"2v04",
"2v05",
"2vyu",
"2ww5",
"2wwc",
"2wwd",
"2x8m",
"2x8o",
"2x8p",
"3hia",
"3hz3",
"3klk",
"3kll",
"3tto",
"3ttq",
"4amc",
"4ayg",
"4cnl"... | 86 | [
"PUB00015629",
"PUB00019347",
"PUB00019371",
"PUB00025616",
"PUB00033715"
] | [
"15576779",
"15539074",
"14527392",
"11694890",
"2879828"
] | [
"Conserved repeat motifs and glucan binding by glucansucrases of oral streptococci and Leuconostoc mesenteroides.",
"Recent trends on the molecular biology of pneumococcal capsules, lytic enzymes, and bacteriophage.",
"Structural basis for selective recognition of pneumococcal cell wall by modular endolysin fro... | [
2004,
2004,
2003,
2001,
1987
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Viruses",
"metagenomes"
] | [
13761,
8,
153,
44
] | 4 | [] | [] | 0 | true | Repeat | Cell wall/choline-binding repeat | Cell wall/choline-binding repeat | Cell_wall/Cho-bd_repeat | 9 |
IPR018338 | 18,338 | Carbonic anhydrase, alpha-class, conserved site | Carbonic_anhydrase_a-class_CS | Conserved_site | 19,746 | false | false | Carbonic anhydrases (CA: ) are zinc metalloenzymes which catalyse the reversible hydration of carbon dioxide to bicarbonate [ , ]. CAs have essential roles in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space; th... | [
"GO:0004089",
"GO:0008270"
] | [
"carbonate dehydratase activity",
"zinc ion binding"
] | [
"molecular_function",
"molecular_function"
] | 2 | [
"PROSITE"
] | [
"PS00162"
] | [
"ALPHA_CA_1"
] | [
19746
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTO... | [
"4.2.1.1",
"PWY-241",
"PWY-5743",
"PWY-5744",
"PWY-5789",
"PWY-6142",
"PWY-7115",
"PWY-7117",
"R-BTA-1237044",
"R-BTA-1247673",
"R-BTA-1475029",
"R-CEL-1237044",
"R-CEL-1247673",
"R-CEL-1475029",
"R-DRE-1237044",
"R-DRE-1247673",
"R-DRE-1475029",
"R-GGA-1237044",
"R-GGA-1247673",... | [
"EC:4.2.1.1",
"METACYC:PWY-241",
"METACYC:PWY-5743",
"METACYC:PWY-5744",
"METACYC:PWY-5789",
"METACYC:PWY-6142",
"METACYC:PWY-7115",
"METACYC:PWY-7117",
"REACTOME:R-BTA-1237044",
"REACTOME:R-BTA-1247673",
"REACTOME:R-BTA-1475029",
"REACTOME:R-CEL-1237044",
"REACTOME:R-CEL-1247673",
"REACTO... | 33 | [
"12ca",
"1a42",
"1am6",
"1avn",
"1azm",
"1bcd",
"1bic",
"1bn1",
"1bn3",
"1bn4",
"1bnm",
"1bnn",
"1bnq",
"1bnt",
"1bnu",
"1bnv",
"1bnw",
"1bv3",
"1bzm",
"1ca2",
"1ca3",
"1cah",
"1cal",
"1cam",
"1can",
"1cao",
"1cay",
"1ccs",
"1cct",
"1ccu",
"1cil",
"1cim"... | 1,402 | [
"PUB00015068",
"PUB00017891",
"PUB00040663",
"PUB00044806",
"PUB00044807",
"PUB00044808",
"PUB00044809",
"PUB00044810",
"PUB00044811"
] | [
"14729686",
"9336012",
"16407248",
"18336305",
"10978542",
"12107142",
"18289884",
"18336318",
"18467453"
] | [
"A novel evolutionary lineage of carbonic anhydrase (epsilon class) is a component of the carboxysome shell.",
"Structure and mechanism of carbonic anhydrase.",
"The structure of beta-carbonic anhydrase from the carboxysomal shell reveals a distinct subclass with one active site for the price of two.",
"Carbo... | [
2004,
1997,
2006,
2008,
2000,
2002,
2008,
2008,
2008
] | 9 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eptesipox virus",
"Eukaryota",
"metagenomes"
] | [
1685,
1,
18028,
32
] | 4 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
19,
3,
36,
16,
31,
23,
27,
41,
16
] | 9 | true | Conserved_site | Carbonic anhydrase, alpha-class, conserved site | Carbonic anhydrase, alpha-class, conserved site | Carbonic_anhydrase_a-class_CS | 5 |
IPR018349 | 18,349 | Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site | Pept_M24A_MAP2_BS | Binding_site | 6,870 | false | false | Over 70 metallopeptidase families have been identified to date. In these enzymes a divalent cation, which is usually zinc but may be cobalt, manganese or copper, activates the water molecule. The metal ion is held in place by amino acid ligands, usually three in number. In some families of co-catalytic metallopeptidase... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS01202"
] | [
"MAP_2"
] | [
6870
] | 1 | [
"EC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"3.4.11.18",
"PWY-7799",
"PWY-7800",
"R-DDI-2514859",
"R-HSA-2514859",
"R-HSA-6798695",
"R-MMU-2514859",
"R-MMU-6798695",
"R-RNO-2514859",
"R-RNO-6798695",
"R-SCE-2514859",
"R-SPO-2514859"
] | [
"EC:3.4.11.18",
"METACYC:PWY-7799",
"METACYC:PWY-7800",
"REACTOME:R-DDI-2514859",
"REACTOME:R-HSA-2514859",
"REACTOME:R-HSA-6798695",
"REACTOME:R-MMU-2514859",
"REACTOME:R-MMU-6798695",
"REACTOME:R-RNO-2514859",
"REACTOME:R-RNO-6798695",
"REACTOME:R-SCE-2514859",
"REACTOME:R-SPO-2514859"
] | 12 | [
"1b59",
"1b6a",
"1bn5",
"1boa",
"1kq0",
"1kq9",
"1qzy",
"1r58",
"1r5g",
"1r5h",
"1wkm",
"1xgm",
"1xgn",
"1xgo",
"1xgs",
"1yw7",
"1yw8",
"1yw9",
"2adu",
"2dfi",
"2ea2",
"2ea4",
"2ga2",
"2oaz",
"2q8k",
"2v6c",
"3fm3",
"3fmq",
"3fmr",
"3j2i",
"5cls",
"5d6e"... | 77 | [
"PUB00000379",
"PUB00003579",
"PUB00004871",
"PUB00005454"
] | [
"8471602",
"7674922",
"7644482",
"8772380"
] | [
"Structure of the cobalt-dependent methionine aminopeptidase from Escherichia coli: a new type of proteolytic enzyme.",
"Evolutionary families of metallopeptidases.",
"Eukaryotic methionyl aminopeptidases: two classes of cobalt-dependent enzymes.",
"Methionine aminopeptidase-1: the MAP of the mitochondrion?"
... | [
1993,
1995,
1995,
1996
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Mimiviridae",
"metagenomes"
] | [
417,
2,
6424,
3,
24
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (st... | [
8,
5,
14,
10,
1,
8,
11,
1,
1,
10
] | 10 | true | Binding_site | Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site | Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site | Pept_M24A_MAP2_BS | 8 |
IPR018350 | 18,350 | Transcription factor COE, conserved site | Transcription_factor_COE_CS | Conserved_site | 6,415 | false | false | The independent cloning of rodent EBF/Olf-1 and Drosophila melanogaster Collier has defined a family of transcription factors, the Collier or COE family [ ]. COE proteins have various functions in different organisms. | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS01345"
] | [
"COE"
] | [
6415
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-381340",
"R-HSA-9752946",
"R-HSA-9844594"
] | [
"REACTOME:R-HSA-381340",
"REACTOME:R-HSA-9752946",
"REACTOME:R-HSA-9844594"
] | 3 | [
"3lyr",
"3mln",
"3mlo",
"3mlp"
] | 4 | [
"PUB00006682"
] | [
"10477305"
] | [
"Head versus trunk patterning in the Drosophila embryo; collier requirement for formation of the intercalary segment."
] | [
1999
] | 1 | [] | [] | 0 | 0 | null | [
"Eumetazoa"
] | [
6415
] | 1 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
77,
6,
15,
17,
19
] | 6 | true | Conserved_site | Transcription factor COE, conserved site | Transcription factor COE, conserved site | Transcription_factor_COE_CS | 3 |
IPR018356 | 18,356 | Transcription regulator, HTH DeoR-type, conserved site | Tscrpt_reg_HTH_DeoR_CS | Conserved_site | 65,208 | false | false | The deoR-type HTH domain is a DNA-binding, helix-turn-helix (HTH) domain of about 50-60 amino acids present in transcription regulators of the deoR family, involved in sugar catabolism. This family of prokaryotic regulators is named after the Escherichia coli protein DeoR, a repressor of the deo operon, which encodes n... | [
"GO:0003700",
"GO:0006355"
] | [
"DNA-binding transcription factor activity",
"regulation of DNA-templated transcription"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROSITE"
] | [
"PS00894"
] | [
"HTH_DEOR_1"
] | [
65208
] | 1 | [] | [] | [] | 0 | [
"2l0k"
] | 1 | [
"PUB00004793",
"PUB00015413",
"PUB00067928"
] | [
"1731335",
"14731281",
"10714997"
] | [
"Opine catabolism and conjugal transfer of the nopaline Ti plasmid pTiC58 are coordinately regulated by a single repressor.",
"Application of AgaR repressor and dominant repressor variants for verification of a gene cluster involved in N-acetylgalactosamine metabolism in Escherichia coli K-12.",
"Purification a... | [
1992,
2004,
2000
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Caudoviricetes",
"Eukaryota",
"unclassified sequences"
] | [
154,
64826,
10,
27,
191
] | 5 | [
"Escherichia coli (strain K12)"
] | [
13
] | 1 | true | Conserved_site | Transcription regulator, HTH DeoR-type, conserved site | Transcription regulator, HTH DeoR-type, conserved site | Tscrpt_reg_HTH_DeoR_CS | 1 |
IPR018357 | 18,357 | Hexapeptide transferase, conserved site | Hexapep_transf_CS | Conserved_site | 106,916 | false | false | A variety of bacterial transferases contain a repeat structure composed of tandem repeats of a [LIV]-G-X(4) hexapeptide, which, in the tertiary structure of LpxA (UDP N-acetylglucosamine acyltransferase) [ ], has been shown to form a left-handed parallel β helix. A number of different transferase protein families conta... | [
"GO:0016740"
] | [
"transferase activity"
] | [
"molecular_function"
] | 1 | [
"PROSITE"
] | [
"PS00101"
] | [
"HEXAPEP_TRANSFERASES"
] | [
106916
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"2.3.1",
"R-CEL-446205",
"R-DDI-446205",
"R-DME-446205",
"R-DRE-446205",
"R-HSA-446205",
"R-MMU-446205",
"R-MTU-936721",
"R-RNO-446205",
"R-SPO-446205",
"R-XTR-446205"
] | [
"EC:2.3.1",
"REACTOME:R-CEL-446205",
"REACTOME:R-DDI-446205",
"REACTOME:R-DME-446205",
"REACTOME:R-DRE-446205",
"REACTOME:R-HSA-446205",
"REACTOME:R-MMU-446205",
"REACTOME:R-MTU-936721",
"REACTOME:R-RNO-446205",
"REACTOME:R-SPO-446205",
"REACTOME:R-XTR-446205"
] | 11 | [
"1g95",
"1g97",
"1hm0",
"1hm8",
"1hm9",
"1hv9",
"1kgq",
"1kgt",
"1khr",
"1kk4",
"1kk5",
"1kk6",
"1kqa",
"1krr",
"1kru",
"1krv",
"1lxa",
"1mr7",
"1mr9",
"1mrl",
"1ocx",
"1s80",
"1ssm",
"1ssq",
"1sst",
"1t3d",
"1tdt",
"2aq9",
"2ic7",
"2jf2",
"2jf3",
"2oi5"... | 190 | [
"PUB00005215",
"PUB00013969",
"PUB00013970",
"PUB00013971"
] | [
"7481807",
"11937062",
"10924115",
"11910040"
] | [
"A left-handed parallel beta helix in the structure of UDP-N-acetylglucosamine acyltransferase.",
"Structure of the lac operon galactoside acetyltransferase.",
"A closer look at the active site of gamma-class carbonic anhydrases: high-resolution crystallographic studies of the carbonic anhydrase from Methanosar... | [
1995,
2002,
2000,
2002
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
2232,
92822,
10616,
29,
1217
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
20,
3,
15,
2,
10,
8,
3,
4,
18,
4,
2,
2,
39
] | 13 | true | Conserved_site | Hexapeptide transferase, conserved site | Hexapeptide transferase, conserved site | Hexapep_transf_CS | 2 |
IPR018358 | 18,358 | Disintegrin, conserved site | Disintegrin_CS | Conserved_site | 16,264 | false | false | This entry represents a conserved central region that contains five of the cysteines involved in disulfide bonds. Disintegrins are a family of small proteins from viper venoms that function as potent inhibitors of both platelet aggregation and integrin-dependent cell adhesion [ , ]. Integrin receptors are involved in c... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00427"
] | [
"DISINTEGRIN_1"
] | [
16264
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-HSA-1442490",
"R-HSA-1474228",
"R-HSA-177929",
"R-HSA-2534343",
"R-HSA-5682910",
"R-HSA-6798695",
"R-HSA-8941237",
"R-HSA-9762292",
"R-MMU-1474228",
"R-MMU-2534343",
"R-MMU-5682910",
"R-MMU-6798695",
"R-MMU-8941237",
"R-MMU-9762292"
] | [
"REACTOME:R-HSA-1442490",
"REACTOME:R-HSA-1474228",
"REACTOME:R-HSA-177929",
"REACTOME:R-HSA-2534343",
"REACTOME:R-HSA-5682910",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-8941237",
"REACTOME:R-HSA-9762292",
"REACTOME:R-MMU-1474228",
"REACTOME:R-MMU-2534343",
"REACTOME:R-MMU-5682910",
"REACTOME... | 14 | [
"1fvl",
"1j2l",
"1l3x",
"1n4y",
"1q7i",
"1q7j",
"1rmr",
"1ro3",
"1tej",
"1z1x",
"2dw0",
"2dw1",
"2dw2",
"2e3x",
"2ech",
"2ero",
"2erp",
"2erq",
"2ljv",
"2m75",
"2m7f",
"2m7h",
"2mop",
"2mp5",
"2pjf",
"2pjg",
"2pji",
"3c05",
"3dsl",
"3g5c",
"3hdb",
"3uci"... | 51 | [
"PUB00000515",
"PUB00004116",
"PUB00026241",
"PUB00026913",
"PUB00027415",
"PUB00030741",
"PUB00035680",
"PUB00035681",
"PUB00035682",
"PUB00035683",
"PUB00035684",
"PUB00035685"
] | [
"1417724",
"1552944",
"14499613",
"14661951",
"12742023",
"15535803",
"15578957",
"15974889",
"12050803",
"16918409",
"16101289",
"15962120"
] | [
"A mammalian epididymal protein with remarkable sequence similarity to snake venom haemorrhagic peptides.",
"A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion.",
"Crystal structure of trimestatin, a disintegrin containing a cell adhesion recognition motif RGD.",
... | [
1992,
1992,
2003,
2003,
2003,
2005,
2004,
2005,
2001,
2006,
2005,
2005
] | 12 | [] | [] | 0 | 0 | null | [
"Eukaryota"
] | [
16264
] | 1 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
51,
9,
63,
67,
80
] | 5 | true | Conserved_site | Disintegrin, conserved site | Disintegrin, conserved site | Disintegrin_CS | 8 |
IPR018359 | 18,359 | Bromodomain, conserved site | Bromodomain_CS | Conserved_site | 61,826 | false | false | Bromodomains are found in a variety of mammalian, invertebrate and yeast DNA-binding proteins [ ]. Bromodomains are highly conserved α-helical motifs that can specifically interact with acetylated lysine residues on histone tails [ , ]. In some proteins, the classical bromodomain has diverged to such an extent that par... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00633"
] | [
"BROMODOMAIN_1"
] | [
61826
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1266695",
"R-BTA-201722",
"R-BTA-3214858",
"R-BTA-3247509",
"R-BTA-8939243",
"R-BTA-9764725",
"R-BTA-9933937",
"R-BTA-9933939",
"R-BTA-9933946",
"R-BTA-9933947",
"R-BTA-9934037",
"R-CEL-114608",
"R-CEL-1234158",
"R-CEL-201722",
"R-CEL-3214847",
"R-CEL-3899300",
"R-CEL-5250924"... | [
"REACTOME:R-BTA-1266695",
"REACTOME:R-BTA-201722",
"REACTOME:R-BTA-3214858",
"REACTOME:R-BTA-3247509",
"REACTOME:R-BTA-8939243",
"REACTOME:R-BTA-9764725",
"REACTOME:R-BTA-9933937",
"REACTOME:R-BTA-9933939",
"REACTOME:R-BTA-9933946",
"REACTOME:R-BTA-9933947",
"REACTOME:R-BTA-9934037",
"REACTOME... | 252 | [
"1e6i",
"1eqf",
"1f68",
"1jm4",
"1jsp",
"1n72",
"1wug",
"1wum",
"1x0j",
"1zs5",
"2d82",
"2d9e",
"2dat",
"2dkw",
"2dvq",
"2dvr",
"2dvs",
"2dvv",
"2e3k",
"2e7n",
"2e7o",
"2f6j",
"2f6n",
"2fsa",
"2g4a",
"2grc",
"2h60",
"2ktb",
"2l5e",
"2l84",
"2l85",
"2n9g"... | 2,059 | [
"PUB00004405",
"PUB00005462",
"PUB00097275",
"PUB00097276"
] | [
"1350857",
"9175470",
"26472704",
"24704920"
] | [
"The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins.",
"The bromodomain revisited.",
"Bromodomains: Translating the words of lysine acetylation into myelin injury and repair.",
"The role of bromodomain proteins in regulating gene expression."
] | [
1992,
1997,
2016,
2012
] | 4 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"bird metagenome"
] | [
61824,
2
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
45,
21,
309,
40,
162,
125,
4,
14,
117,
9,
7,
61
] | 12 | true | Conserved_site | Bromodomain, conserved site | Bromodomain, conserved site | Bromodomain_CS | 1 |
IPR018360 | 18,360 | Calcitonin, conserved site | Calcitonin_CS | Conserved_site | 2,140 | false | false | Calcitonin [ ] is a 32 amino acid polypeptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in the blood, by promoting the incorporation of these ions in the bones. This is the alpha type. Alternative splicing of the gene coding for calcitonin produces a distantly related peptid... | [
"GO:0005179",
"GO:0005576"
] | [
"hormone activity",
"extracellular region"
] | [
"molecular_function",
"cellular_component"
] | 2 | [
"PROSITE"
] | [
"PS00258"
] | [
"CALCITONIN"
] | [
2140
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CFA-419812",
"R-HSA-210745",
"R-HSA-418555",
"R-HSA-419812",
"R-HSA-977225",
"R-MMU-418555",
"R-MMU-419812",
"R-RNO-419812"
] | [
"REACTOME:R-CFA-419812",
"REACTOME:R-HSA-210745",
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-419812",
"REACTOME:R-HSA-977225",
"REACTOME:R-MMU-418555",
"REACTOME:R-MMU-419812",
"REACTOME:R-RNO-419812"
] | 8 | [
"1bku",
"1byv",
"1bzb",
"1fb9",
"2g48",
"2glg",
"2glh",
"2jxz",
"2kb8",
"2kj7",
"2l86",
"3g7v",
"3g7w",
"3hgz",
"5k5g",
"5mgq",
"6e3y",
"6niy",
"6ucj",
"6uck",
"6vw2",
"6y1a",
"6zrf",
"6zrq",
"6zrr",
"7bg0",
"7knu",
"7m61",
"7m62",
"7m64",
"7m65",
"7tyf"... | 86 | [
"PUB00000472",
"PUB00002606"
] | [
"3060108",
"2407732"
] | [
"Peptides from the calcitonin genes: molecular genetics, structure and function.",
"Islet amyloid polypeptide. A new beta cell secretory product related to islet amyloid deposits."
] | [
1988,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Vertebrata"
] | [
2140
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
7,
7,
8,
12
] | 4 | true | Conserved_site | Calcitonin, conserved site | Calcitonin, conserved site | Calcitonin_CS | 7 |
IPR018363 | 18,363 | CD59 antigen, conserved site | CD59_antigen_CS | Conserved_site | 2,565 | false | false | CD59 (also called 1F-5Ag, H19, HRF20, MACIF, MIRL, P-18 or protectin) inhibits formation of membrane attack complex (MAC), thus protecting cells from complement mediated lysis. It has a signalling role, as a GPI-anchored molecule, in T cell activation and appears to have some role in cell adhesion through CD2 (controve... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00983"
] | [
"LY6_UPAR"
] | [
2565
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-162791",
"R-BTA-163125",
"R-BTA-6798695",
"R-BTA-75205",
"R-HSA-162791",
"R-HSA-163125",
"R-HSA-204005",
"R-HSA-5694530",
"R-HSA-6798695",
"R-HSA-6807878",
"R-HSA-75205",
"R-HSA-977606",
"R-MMU-162791",
"R-MMU-163125",
"R-MMU-6798695",
"R-MMU-75205",
"R-MMU-8963889",
"R-MMU-... | [
"REACTOME:R-BTA-162791",
"REACTOME:R-BTA-163125",
"REACTOME:R-BTA-6798695",
"REACTOME:R-BTA-75205",
"REACTOME:R-HSA-162791",
"REACTOME:R-HSA-163125",
"REACTOME:R-HSA-204005",
"REACTOME:R-HSA-5694530",
"REACTOME:R-HSA-6798695",
"REACTOME:R-HSA-6807878",
"REACTOME:R-HSA-75205",
"REACTOME:R-HSA-9... | 30 | [
"1cdq",
"1cdr",
"1cds",
"1erg",
"1erh",
"2fd6",
"2i9b",
"2j8b",
"2ofs",
"2uwr",
"2ux2",
"3laq",
"4bik",
"5imt",
"5imy",
"6aex",
"6zd0",
"7e17",
"7v63",
"8b0f",
"8b0g",
"8b0h",
"8cn6"
] | 23 | [
"PUB00002692",
"PUB00002796"
] | [
"1850423",
"8394346"
] | [
"The ligand-binding domain of the cell surface receptor for urokinase-type plasminogen activator.",
"Localization of the disulfide bonds in the NH2-terminal domain of the cellular receptor for human urokinase-type plasminogen activator. A domain structure belonging to a novel superfamily of glycolipid-anchored me... | [
1991,
1993
] | 2 | [] | [] | 0 | 0 | null | [
"Candidatus Contendobacter odensis Run_B_J11",
"Eumetazoa",
"Saimiriine herpesvirus 2"
] | [
1,
2561,
3
] | 3 | [
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
20,
26,
27
] | 3 | true | Conserved_site | CD59 antigen, conserved site | CD59 antigen, conserved site | CD59_antigen_CS | 5 |
IPR018365 | 18,365 | Cell cycle, FtsW / RodA / SpoVE, conserved site | Cell_cycle_FtsW-rel_CS | Conserved_site | 29,466 | false | false | A number of prokaryotic integral membrane proteins involved in cell cycle processes have been found to be structurally related [ , ]. These proteins include, the Escherichia coli and related bacteria cell division protein ftsW and the rod shape-determining protein rodA (or mrdB), the Bacillus subtilis stage V sporulati... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PROSITE"
] | [
"PS00428"
] | [
"FTSW_RODA_SPOVE"
] | [
29466
] | 1 | [
"EC"
] | [
"2.4.99.28"
] | [
"EC:2.4.99.28"
] | 1 | [
"6bar",
"6bas",
"6pl5",
"6pl6",
"8bh1",
"8p1u",
"8tj3"
] | 7 | [
"PUB00002092",
"PUB00003802",
"PUB00015509",
"PUB00020746",
"PUB00042955",
"PUB00071895",
"PUB00083894",
"PUB00083917",
"PUB00083918",
"PUB00083919",
"PUB00086588"
] | [
"2509435",
"2113157",
"12626683",
"15576787",
"2644207",
"9622350",
"27525505",
"9218774",
"1391053",
"27895631",
"27643381"
] | [
"Structural similarity among Escherichia coli FtsW and RodA proteins and Bacillus subtilis SpoVE protein, which function in cell division, cell elongation, and spore formation, respectively.",
"The life-cycle proteins RodA of Escherichia coli and SpoVE of Bacillus subtilis have very similar primary structures.",
... | [
1989,
1990,
2003,
2004,
1989,
1998,
2016,
1997,
1992,
2016,
2016
] | 11 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
28889,
39,
538
] | 3 | [
"Escherichia coli (strain K12)"
] | [
2
] | 1 | true | Conserved_site | Cell cycle, FtsW / RodA / SpoVE, conserved site | Cell cycle, FtsW / RodA / SpoVE, conserved site | Cell_cycle_FtsW-rel_CS | 6 |
IPR018366 | 18,366 | Carbohydrate-binding type-2, conserved site | CBM2_CS | Conserved_site | 4,289 | false | false | The microbial degradation of cellulose and xylans requires several types of enzyme such as endoglucanases ( ), cellobiohydrolases ( ) (exoglucanases), or xylanases ( ) [ ]. Structurally, cellulases and xylanases generally consist of a catalytic domain joined to a cellulose-binding domain (CBD) by a short linker sequenc... | [
"GO:0004553",
"GO:0030246",
"GO:0005975"
] | [
"hydrolase activity, hydrolyzing O-glycosyl compounds",
"carbohydrate binding",
"carbohydrate metabolic process"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"PROSITE"
] | [
"PS00561"
] | [
"CBM2_A"
] | [
4289
] | 1 | [
"EC"
] | [
"3.2.1"
] | [
"EC:3.2.1"
] | 1 | [
"1exg",
"1exh",
"2rtt",
"6qfs"
] | 4 | [
"PUB00001403",
"PUB00003608",
"PUB00005068",
"PUB00016254"
] | [
"1761039",
"1886523",
"1812490",
"10973978"
] | [
"Structural and functional relationships in two families of beta-1,4-glycanases.",
"Domains in microbial beta-1, 4-glycanases: sequence conservation, function, and enzyme families.",
"Bacterial cellulose-binding domain-like sequences in eucaryotic polypeptides.",
"The structural basis for the ligand specifici... | [
1991,
1991,
1991,
2000
] | 4 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Natronorubrum",
"unclassified sequences"
] | [
4271,
6,
2,
10
] | 4 | [] | [] | 0 | true | Conserved_site | Carbohydrate-binding type-2, conserved site | Carbohydrate-binding type-2, conserved site | CBM2_CS | 8 |
IPR018368 | 18,368 | ClpA/B, conserved site 1 | ClpA/B_CS1 | Conserved_site | 70,726 | false | false | The ClpA/B family of ATP-binding proteins includes the regulatory subunit of the ATP-dependent protease Clp, ClpA; heat shock proteins ClpB, 104 and 78; and chloroplast proteins CD4a (ClpC) and CD4b [ , ]. The proteins are thought to protect cells from stress by controlling the aggregation and denaturation of vital cel... | [
"GO:0005524"
] | [
"ATP binding"
] | [
"molecular_function"
] | 1 | [
"PROSITE"
] | [
"PS00870"
] | [
"CLPAB_1"
] | [
70726
] | 1 | [] | [] | [] | 0 | [
"1jbk",
"1ksf",
"1qvr",
"1r6b",
"2p65",
"3j3r",
"3j3s",
"3j3t",
"3j3u",
"3pxg",
"3pxi",
"4ciu",
"4d2q",
"4d2u",
"4d2x",
"4hse",
"5d4w",
"5kne",
"5ofo",
"5og1",
"5vjh",
"5vy8",
"5vy9",
"5vya",
"5wbw",
"5zui",
"6ahf",
"6amn",
"6azy",
"6d00",
"6dju",
"6djv"... | 91 | [
"PUB00004102",
"PUB00004707"
] | [
"1896074",
"2185473"
] | [
"Hsp104 is a highly conserved protein with two essential nucleotide-binding sites.",
"Conservation of the regulatory subunit for the Clp ATP-dependent protease in prokaryotes and eukaryotes."
] | [
1991,
1990
] | 2 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
51,
59991,
9873,
7,
804
] | 5 | [
"Arabidopsis thaliana",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
"Zea mays"
] | [
28,
2,
2,
21,
2,
2,
51
] | 7 | true | Conserved_site | ClpA/B, conserved site 1 | ClpA/B, conserved site 1 | ClpA/B_CS1 | 8 |
IPR018369 | 18,369 | Chaperonin GroES, conserved site | Chaprnonin_Cpn10_CS | Conserved_site | 28,171 | false | false | The chaperonins are 'helper' molecules required for correct folding and subsequent assembly of some proteins [ ]. These are required for normal cell growth [ ], and are stress-induced, acting to stabilise or protect disassembled polypeptides under heat-shock conditions. Type I chaperonins present in eubacteria, mitocho... | [
"GO:0005524",
"GO:0006457"
] | [
"ATP binding",
"protein folding"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROSITE"
] | [
"PS00681"
] | [
"CHAPERONINS_CPN10"
] | [
28171
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-9013408",
"R-HSA-9013408",
"R-HSA-9841251",
"R-MMU-9013408",
"R-RNO-9013408"
] | [
"REACTOME:R-BTA-9013408",
"REACTOME:R-HSA-9013408",
"REACTOME:R-HSA-9841251",
"REACTOME:R-MMU-9013408",
"REACTOME:R-RNO-9013408"
] | 5 | [
"1aon",
"1gru",
"1hx5",
"1lep",
"1p3h",
"1pcq",
"1pf9",
"1svt",
"1sx4",
"1wnr",
"2c7c",
"2c7d",
"3nx6",
"3wvl",
"3zpz",
"3zq0",
"3zq1",
"4pj1",
"4pkn",
"4pko",
"4v4o",
"5opx",
"6ht7",
"6mrc",
"6mrd",
"7ekq",
"7pbj",
"7pbx",
"7vwx",
"8ba9",
"8baa",
"8bkz"... | 54 | [
"PUB00002183",
"PUB00004022",
"PUB00004159",
"PUB00004550",
"PUB00009990"
] | [
"1350777",
"2897629",
"7901771",
"1349837",
"12354603"
] | [
"Cloning, sequencing, mapping, and transcriptional analysis of the groESL operon from Bacillus subtilis.",
"Homologous plant and bacterial proteins chaperone oligomeric protein assembly.",
"Identification of nucleotide-binding regions in the chaperonin proteins GroEL and GroES.",
"cDNA clones encoding Arabido... | [
1992,
1988,
1993,
1992,
2002
] | 5 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Viruses",
"unclassified sequences"
] | [
22536,
5156,
48,
22,
409
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 2045... | [
10,
1,
1,
5,
2,
1,
16,
4,
1,
1,
17
] | 11 | true | Conserved_site | Chaperonin GroES, conserved site | Chaperonin GroES, conserved site | Chaprnonin_Cpn10_CS | 3 |
IPR018370 | 18,370 | Chaperonin Cpn60, conserved site | Chaperonin_Cpn60_CS | Conserved_site | 43,044 | false | false | The assembly of proteins has been thought to be the sole result of properties inherent in the primary sequence of polypeptides themselves. In some cases, however, structural information from other protein molecules is required for correct folding and subsequent assembly into oligomers [ ]. These `helper' molecules are ... | [
"GO:0005524",
"GO:0006457"
] | [
"ATP binding",
"protein folding"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROSITE"
] | [
"PS00296"
] | [
"CHAPERONINS_CPN60"
] | [
43044
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"5.6.1.7",
"R-CEL-9837999",
"R-DDI-9837999",
"R-DME-9837999",
"R-GGA-1268020",
"R-GGA-9837999",
"R-HSA-1268020",
"R-HSA-8869496",
"R-HSA-9837999",
"R-HSA-9841251",
"R-MMU-1268020",
"R-MMU-9837999",
"R-RNO-1268020",
"R-RNO-9837999",
"R-SCE-1268020",
"R-SCE-9837999"
] | [
"EC:5.6.1.7",
"REACTOME:R-CEL-9837999",
"REACTOME:R-DDI-9837999",
"REACTOME:R-DME-9837999",
"REACTOME:R-GGA-1268020",
"REACTOME:R-GGA-9837999",
"REACTOME:R-HSA-1268020",
"REACTOME:R-HSA-8869496",
"REACTOME:R-HSA-9837999",
"REACTOME:R-HSA-9841251",
"REACTOME:R-MMU-1268020",
"REACTOME:R-MMU-9837... | 16 | [
"1aon",
"1gr5",
"1grl",
"1gru",
"1iok",
"1kp8",
"1mnf",
"1oel",
"1pcq",
"1pf9",
"1sjp",
"1ss8",
"1svt",
"1sx3",
"1sx4",
"1xck",
"2c7c",
"2c7d",
"2c7e",
"2cgt",
"2eu1",
"2nwc",
"2yey",
"2ynj",
"3c9v",
"3cau",
"3e76",
"3rtk",
"3wvl",
"3zpz",
"3zq0",
"3zq1"... | 131 | [
"PUB00000632",
"PUB00001725",
"PUB00002183",
"PUB00004022",
"PUB00004190",
"PUB00004550"
] | [
"1347461",
"1672279",
"1350777",
"2897629",
"7935790",
"1349837"
] | [
"Cloning and nucleotide sequence of the Brucella abortus groE operon.",
"Sequence analysis of the Legionella micdadei groELS operon.",
"Cloning, sequencing, mapping, and transcriptional analysis of the groESL operon from Bacillus subtilis.",
"Homologous plant and bacterial proteins chaperone oligomeric protei... | [
1992,
1991,
1992,
1988,
1994,
1992
] | 6 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanobacteriota",
"Viruses",
"unclassified sequences"
] | [
32103,
10183,
68,
37,
653
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
26,
4,
1,
4,
1,
9,
1,
1,
25,
3,
1,
37
] | 12 | true | Conserved_site | Chaperonin Cpn60, conserved site | Chaperonin Cpn60, conserved site | Chaperonin_Cpn60_CS | 4 |
IPR018371 | 18,371 | Chitin-binding, type 1, conserved site | Chitin-binding_1_CS | Conserved_site | 10,171 | false | false | A number of plant and fungal proteins that bind N-acetylglucosamine (e.g. solanaceous lectins of tomato and potato, plant endochitinases, the wound-induced proteins: hevein, win1 and win2, and the Kluyveromyces lactis killer toxin alpha subunit) contain this domain [ ]. The domain may occur in one or more copies and is... | [
"GO:0008061"
] | [
"chitin binding"
] | [
"molecular_function"
] | 1 | [
"PROSITE"
] | [
"PS00026"
] | [
"CHIT_BIND_I_1"
] | [
10171
] | 1 | [
"EC",
"METACYC",
"METACYC",
"METACYC"
] | [
"3.2.1.14",
"PWY-6855",
"PWY-6902",
"PWY-7822"
] | [
"EC:3.2.1.14",
"METACYC:PWY-6855",
"METACYC:PWY-6902",
"METACYC:PWY-7822"
] | 4 | [
"1ehd",
"1ehh",
"1eis",
"1en2",
"1enm",
"1hev",
"1iqb",
"1k7t",
"1k7u",
"1k7v",
"1mmc",
"1p9g",
"1p9z",
"1q9b",
"1t0w",
"1uha",
"1ulk",
"1ulm",
"1uln",
"1wgc",
"1wgt",
"1wkx",
"1znt",
"1zuv",
"1zwu",
"2cwg",
"2dkv",
"2kus",
"2n1s",
"2uvo",
"2wgc",
"2x3t"... | 52 | [
"PUB00001396",
"PUB00002707",
"PUB00003415"
] | [
"2070799",
"1375935",
"1757999"
] | [
"Kluyveromyces lactis toxin has an essential chitinase activity.",
"The gene for stinging nettle lectin (Urtica dioica agglutinin) encodes both a lectin and a chitinase.",
"Evolution of a family of N-acetylglucosamine binding proteins containing the disulfide-rich domain of wheat germ agglutinin."
] | [
1991,
1992,
1991
] | 3 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Pseudomonadota"
] | [
10165,
6
] | 2 | [
"Arabidopsis thaliana",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
32,
1,
23,
40
] | 4 | true | Conserved_site | Chitin-binding, type 1, conserved site | Chitin-binding, type 1, conserved site | Chitin-binding_1_CS | 6 |
IPR018372 | 18,372 | Chloramphenicol acetyltransferase, active site | Chloramphenicol_AcTrfase_AS | Active_site | 1,074 | false | false | Chloramphenicol acetyltransferase (CAT) ( ) [ ] catalyzes the acetyl-CoA dependent acetylation of chloramphenicol (Cm), an antibiotic which inhibits prokaryotic peptidyltransferase activity. Acetylation of Cm by CAT inactivates the antibiotic. The pattern signature for this entry contains the histidine residue, located... | [
"GO:0008811"
] | [
"chloramphenicol O-acetyltransferase activity"
] | [
"molecular_function"
] | 1 | [
"PROSITE"
] | [
"PS00100"
] | [
"CAT"
] | [
1074
] | 1 | [
"EC"
] | [
"2.3.1.28"
] | [
"EC:2.3.1.28"
] | 1 | [
"1cla",
"1noc",
"1pd5",
"1q23",
"1qca",
"3cla",
"3u9b",
"3u9f",
"4cla",
"6x7q",
"9m5s"
] | 11 | [
"PUB00000094",
"PUB00002174",
"PUB00006247"
] | [
"1867713",
"1314803",
"2187098"
] | [
"The zipper-like folding of collagen triple helices and the effects of mutations that disrupt the zipper.",
"The chloramphenicol acetyltransferase gene of Tn2424: a new breed of cat.",
"Refined crystal structure of type III chloramphenicol acetyltransferase at 1.75 A resolution."
] | [
1991,
1992,
1990
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"Methanosarcinales",
"Plasmid pSBK203",
"Viruses",
"unclassified sequences"
] | [
1041,
5,
4,
1,
10,
13
] | 6 | [] | [] | 0 | true | Active_site | Chloramphenicol acetyltransferase, active site | Chloramphenicol acetyltransferase, active site | Chloramphenicol_AcTrfase_AS | 6 |
IPR018375 | 18,375 | Coproporphyrinogen III oxidase, conserved site | Coprogen_oxidase_CS | Conserved_site | 12,338 | false | false | Coprogen oxidase (i.e. coproporphyrin III oxidase or coproporphyrinogenase) catalyses the oxidative decarboxylation of coproporphyrinogen III to proto-porhyrinogen IX in the haem and chlorophyll biosynthetic pathways [ , ]. The protein is a homodimer containing two internally bound iron atoms per molecule of native pro... | [
"GO:0004109",
"GO:0006779"
] | [
"coproporphyrinogen oxidase activity",
"porphyrin-containing compound biosynthetic process"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"PROSITE"
] | [
"PS01021"
] | [
"COPROGEN_OXIDASE"
] | [
12338
] | 1 | [
"EC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"1.3.3.3",
"PWY-7159",
"R-DME-189451",
"R-HSA-189451",
"R-MMU-189451",
"R-RNO-189451",
"R-SCE-189451",
"R-SPO-189451"
] | [
"EC:1.3.3.3",
"METACYC:PWY-7159",
"REACTOME:R-DME-189451",
"REACTOME:R-HSA-189451",
"REACTOME:R-MMU-189451",
"REACTOME:R-RNO-189451",
"REACTOME:R-SCE-189451",
"REACTOME:R-SPO-189451"
] | 8 | [
"1tk1",
"1tkl",
"1tlb",
"1txn",
"1vju",
"2aex",
"2qt8",
"3dwr",
"3dws",
"3e8j",
"3ejo",
"5eo6",
"8t7w"
] | 13 | [
"PUB00001344",
"PUB00002804",
"PUB00004565"
] | [
"3516695",
"8407975",
"8219054"
] | [
"Purification and properties of coproporphyrinogen oxidase from the yeast Saccharomyces cerevisiae.",
"Coproporphyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation.",
"A soybean coproporphyrinogen oxidase gene is highly expressed in root nodules."
] | [
1986,
1993,
1993
] | 3 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
8932,
3321,
85
] | 3 | [
"Arabidopsis thaliana",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (strain 972 / ATCC 24843)",
... | [
3,
1,
2,
1,
1,
2,
3,
3,
1,
1,
8
] | 11 | true | Conserved_site | Coproporphyrinogen III oxidase, conserved site | Coproporphyrinogen III oxidase, conserved site | Coprogen_oxidase_CS | 9 |
IPR018376 | 18,376 | Enoyl-CoA hydratase/isomerase, conserved site | Enoyl-CoA_hyd/isom_CS | Conserved_site | 111,225 | false | false | The crotonase superfamily is comprised of mechanistically diverse proteins that share a conserved trimeric quaternary structure (sometimes a hexamer consisting of a dimer of trimers), the core of which consists of 4 turns of a (β/β/α)n superhelix. Some enzymes in the superfamily have been shown to display dehalogenase,... | [
"GO:0003824"
] | [
"catalytic activity"
] | [
"molecular_function"
] | 1 | [
"PROSITE"
] | [
"PS00166"
] | [
"ENOYL_COA_HYDRATASE"
] | [
111225
] | 1 | [
"EC",
"EC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"METACYC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"4.2.1",
"4.2.1.17",
"PWY-1361",
"PWY-5136",
"PWY-5138",
"PWY-6443",
"PWY-6446",
"PWY-6458",
"PWY-7007",
"PWY-7606",
"PWY-7654",
"PWY-7656",
"PWY-7726",
"PWY-8179",
"PWY-8181",
"PWY-8182",
"PWY-8347",
"PWY-8354",
"R-BTA-70895",
"R-BTA-77310",
"R-BTA-77346",
"R-BTA-77348",
... | [
"EC:4.2.1",
"EC:4.2.1.17",
"METACYC:PWY-1361",
"METACYC:PWY-5136",
"METACYC:PWY-5138",
"METACYC:PWY-6443",
"METACYC:PWY-6446",
"METACYC:PWY-6458",
"METACYC:PWY-7007",
"METACYC:PWY-7606",
"METACYC:PWY-7654",
"METACYC:PWY-7656",
"METACYC:PWY-7726",
"METACYC:PWY-8179",
"METACYC:PWY-8181",
... | 82 | [
"1dci",
"1dub",
"1ef8",
"1ef9",
"1ey3",
"1hzd",
"1jxz",
"1mj3",
"1nzy",
"1sg4",
"1uiy",
"1wdk",
"1wdl",
"1wdm",
"1xx4",
"2d3t",
"2dub",
"2ej5",
"2hw5",
"2iex",
"2j5i",
"2pbp",
"2ppy",
"2q2x",
"2q34",
"2q35",
"2qq3",
"2vre",
"2vss",
"2vsu",
"2wtb",
"2x58"... | 167 | [
"PUB00000748",
"PUB00024165",
"PUB00024526",
"PUB00025845",
"PUB00027360",
"PUB00031259",
"PUB00033366",
"PUB00035962",
"PUB00035963",
"PUB00035964",
"PUB00035965",
"PUB00035966",
"PUB00035967"
] | [
"1958319",
"9739087",
"10769118",
"11738050",
"12445775",
"15138275",
"16131752",
"11263873",
"16096274",
"17198383",
"8679561",
"11551212",
"5229654"
] | [
"Mitochondrial 3-2trans-Enoyl-CoA isomerase. Purification, cloning, expression, and mitochondrial import of the key enzyme of unsaturated fatty acid beta-oxidation.",
"The crystal structure of dienoyl-CoA isomerase at 1.5 A resolution reveals the importance of aspartate and glutamate sidechains for catalysis.",
... | [
1991,
1998,
2000,
2001,
2002,
2004,
2005,
2001,
2005,
2007,
1996,
2001,
1966
] | 13 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences"
] | [
1938,
85735,
21977,
1,
1574
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
20,
6,
18,
5,
5,
28,
18,
3,
20,
36,
1,
51
] | 12 | true | Conserved_site | Enoyl-CoA hydratase/isomerase, conserved site | Enoyl-CoA hydratase/isomerase, conserved site | Enoyl-CoA_hyd/isom_CS | 4 |
IPR018378 | 18,378 | C-type lectin, conserved site | C-type_lectin_CS | Conserved_site | 54,087 | false | false | Lectins occur in plants, animals, bacteria and viruses. Initially described for their carbohydrate-binding activity [ ], they are now recognised as a more diverse group of proteins, some of which are involved in protein-protein, protein-lipid or protein-nucleic acid interactions [ ]. There are at least twelve structura... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00615"
] | [
"C_TYPE_LECTIN_1"
] | [
54087
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOM... | [
"R-BTA-1482788",
"R-BTA-1482801",
"R-BTA-1482839",
"R-BTA-1482922",
"R-BTA-1482925",
"R-BTA-1483166",
"R-BTA-166016",
"R-BTA-166662",
"R-BTA-166663",
"R-BTA-1971475",
"R-BTA-198933",
"R-BTA-2022870",
"R-BTA-2022923",
"R-BTA-2024101",
"R-BTA-202733",
"R-BTA-3000178",
"R-BTA-3000480",
... | [
"REACTOME:R-BTA-1482788",
"REACTOME:R-BTA-1482801",
"REACTOME:R-BTA-1482839",
"REACTOME:R-BTA-1482922",
"REACTOME:R-BTA-1482925",
"REACTOME:R-BTA-1483166",
"REACTOME:R-BTA-166016",
"REACTOME:R-BTA-166662",
"REACTOME:R-BTA-166663",
"REACTOME:R-BTA-1971475",
"REACTOME:R-BTA-198933",
"REACTOME:R-... | 156 | [
"1afa",
"1afb",
"1afd",
"1b08",
"1bch",
"1bcj",
"1bj3",
"1buu",
"1bv4",
"1byf",
"1c3a",
"1dv8",
"1egg",
"1egi",
"1esl",
"1fif",
"1fih",
"1fvu",
"1g1q",
"1g1r",
"1g1s",
"1g1t",
"1h8u",
"1htn",
"1hup",
"1ijk",
"1iod",
"1ixx",
"1j34",
"1j35",
"1jzn",
"1k9i"... | 312 | [
"PUB00007964",
"PUB00042634",
"PUB00042635",
"PUB00042636",
"PUB00042637",
"PUB00042638",
"PUB00042639",
"PUB00042640",
"PUB00042641",
"PUB00042642",
"PUB00042643",
"PUB00042644",
"PUB00042645"
] | [
"10924498",
"14533786",
"12223269",
"17497244",
"12223277",
"12223278",
"16343883",
"17072021",
"7876089",
"17702679",
"15813707",
"15476922",
"14519388"
] | [
"Multiplicity, structures, and endocrine and exocrine natures of eel fucose-binding lectins.",
"The structural basis for carbohydrate recognition by lectins.",
"Animal lectins: a historical introduction and overview.",
"Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and sur... | [
2000,
2001,
2002,
2007,
2002,
2002,
2006,
2006,
1995,
2007,
2005,
2004,
2003
] | 13 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"metagenomes"
] | [
141,
53942,
4
] | 3 | [
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
32,
245,
18,
119,
124,
177
] | 6 | true | Conserved_site | C-type lectin, conserved site | C-type lectin, conserved site | C-type_lectin_CS | 1 |
IPR018379 | 18,379 | BEN domain | BEN_domain | Domain | 12,355 | false | false | The BEN domain is found in diverse proteins including: SMAR1 (Scaffold/Matrix attachment region-binding protein 1; also known as BANP), a tumour-suppressor MAR-binding protein that down-regulates Cyclin D1 expression by recruiting HDAC1-mSin3A co-repressor complex at Cyclin D1 promoter locus; SMAR1 is the target of pro... | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"PFAM",
"PROFILE",
"SMART"
] | [
"PF10523",
"PS51457",
"SM01025"
] | [
"BEN",
"BEN",
"BEN"
] | [
11117,
11892,
10402
] | 3 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-DRE-6804759",
"R-DRE-9766229",
"R-HSA-6804759",
"R-HSA-9766229",
"R-MMU-6804759",
"R-MMU-9766229",
"R-XTR-6804759"
] | [
"REACTOME:R-DRE-6804759",
"REACTOME:R-DRE-9766229",
"REACTOME:R-HSA-6804759",
"REACTOME:R-HSA-9766229",
"REACTOME:R-MMU-6804759",
"REACTOME:R-MMU-9766229",
"REACTOME:R-XTR-6804759"
] | 7 | [
"4ix7",
"4x0g",
"5jno",
"7bv9",
"7v9f",
"7v9g",
"7v9h",
"7v9i",
"7w27",
"7yug",
"7yuk",
"7yul",
"7yun",
"8htx",
"8yzs",
"8yzt"
] | 16 | [
"PUB00007523",
"PUB00044170",
"PUB00044818",
"PUB00044819",
"PUB00044820",
"PUB00044821",
"PUB00097582"
] | [
"10854161",
"18203771",
"16166625",
"17726044",
"17945361",
"15094203",
"25561495"
] | [
"Identification by mass spectroscopy of three major early proteins associated with virosomes in vaccinia virus-infected cells.",
"BEN: a novel domain in chromatin factors and DNA viral proteins.",
"Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.",
... | [
1999,
2008,
2005,
2007,
2008,
2004,
2015
] | 7 | [] | [] | 0 | 0 | null | [
"Metazoa",
"Viruses"
] | [
12178,
177
] | 2 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
66,
5,
28,
16,
28
] | 5 | true | Domain | BEN domain | BEN domain | BEN_domain | 4 |
IPR018382 | 18,382 | DNA polymerase III, psi subunit, subgroup | DNA_pol_III_psi_subgr | Family | 813 | false | false | DNA-directed DNA polymerase ( ) catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The enzyme also has 3' to 5' exonuclease activity. It has a core compose... | [
"GO:0003887",
"GO:0008408",
"GO:0006260"
] | [
"DNA-directed DNA polymerase activity",
"3'-5' exonuclease activity",
"DNA replication"
] | [
"molecular_function",
"molecular_function",
"biological_process"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00664"
] | [
"DNA_III_psi"
] | [
813
] | 1 | [
"GP"
] | [
"GenProp0263"
] | [
"GP:GenProp0263"
] | 1 | [
"1em8",
"3sxu",
"8giy",
"8giz",
"8gj0",
"8gj1",
"8gj2",
"8gj3"
] | 8 | [] | [] | [] | [] | 0 | [
"IPR004615"
] | [] | 1 | 0 | 1 | [
"Gammaproteobacteria",
"Trichuris trichiura"
] | [
812,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | DNA polymerase III, psi subunit, subgroup | DNA polymerase III, psi subunit, subgroup | DNA_pol_III_psi_subgr | 3 |
IPR018383 | 18,383 | Uncharacterised protein family UPF0324, prokaryote | UPF0324_pro | Family | 17,410 | false | false | This entry represents a family of uncharacterised multi-pass membrane proteins. | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF03601",
"PTHR30106"
] | [
"Cons_hypoth698",
""
] | [
17395,
17295
] | 2 | [] | [] | [] | 0 | [] | 0 | [] | [] | [] | [] | 0 | [] | [
"IPR004630"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Siphoviridae sp. ctBLh2",
"Sym plasmid",
"unclassified sequences"
] | [
284,
16708,
214,
1,
1,
202
] | 6 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Uncharacterised protein family UPF0324, prokaryote | Uncharacterised protein family UPF0324, prokaryote | UPF0324_pro | 9 |
IPR018384 | 18,384 | DNA-binding protein Tfx, euryarchaeota | Tfx_DNA-bd_euryarc | Family | 321 | false | false | This entry represents a family of Tfx DNA-binding proteins, which is restricted to euryarchaeota. TfX has a 2-layer α/β topology. Homology among the members is strongest in the helix-turn-helix-containing N-terminal region. Tfx from Methanothermobacter thermautotrophicus is associated with the operon for molybdenum for... | [
"GO:0003677"
] | [
"DNA binding"
] | [
"molecular_function"
] | 1 | [
"HAMAP",
"PIRSF"
] | [
"MF_00620",
"PIRSF004932"
] | [
"HTH_type_Tfx",
"DNA_bind_Tfx"
] | [
55,
315
] | 2 | [] | [] | [] | 0 | [
"1nr3",
"8hno",
"8hnp"
] | 3 | [
"PUB00010728"
] | [
"10027980"
] | [
"The DNA binding protein Tfx from Methanobacterium thermoautotrophicum: structure, DNA binding properties and transcriptional regulation."
] | [
1999
] | 1 | [
"IPR004645"
] | [] | 1 | 0 | 1 | [
"Archaea",
"hydrocarbon metagenome"
] | [
319,
2
] | 2 | [] | [] | 0 | true | Family | DNA-binding protein Tfx, euryarchaeota | DNA-binding protein Tfx, euryarchaeota | Tfx_DNA-bd_euryarc | 7 |
IPR018385 | 18,385 | C4-dicarboxylate anaerobic carrier-like | C4_dicarb_anaerob_car-like | Family | 13,290 | false | false | Escherichia coli contains four different secondary carriers (DcuA, DcuB, DcuC, and DctA) for C4-dicarboxylates [ , , , ] DcuA is used for aerobic growth on C4-dicarboxylates [ , ], whereas the Dcu carriers (encoded by the dcuA, dcuB, and dcuC genes) are used under anaerobic conditions and form a distinct family of carr... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"PFAM"
] | [
"PF03606"
] | [
"DcuC"
] | [
13290
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00000013",
"PUB00011102",
"PUB00033878",
"PUB00033879",
"PUB00033884",
"PUB00033885",
"PUB00033886",
"PUB00033887",
"PUB00033888",
"PUB00033889",
"PUB00033890",
"PUB00033891"
] | [
"9889977",
"9765574",
"7961398",
"9852003",
"10482502",
"1512189",
"8955408",
"5541510",
"8020497",
"9230919",
"9973351",
"10368146"
] | [
"Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya.",
"Fumarate regulation of gene expression in Escherichia coli by the DcuSR (dcuSR genes) two-component regulatory system.",
"Escherichia coli possesses two homologous anaerobic C4-dicarboxylate membr... | [
1998,
1998,
1994,
1998,
1999,
1992,
1996,
1971,
1994,
1997,
1999,
1999
] | 12 | [] | [
"IPR004669"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
13,
13119,
16,
142
] | 4 | [
"Escherichia coli (strain K12)"
] | [
3
] | 1 | true | Family | C4-dicarboxylate anaerobic carrier-like | C4-dicarboxylate anaerobic carrier-like | C4_dicarb_anaerob_car-like | 8 |
IPR018389 | 18,389 | TRAP transporter solute receptor DctP | DctP_fam | Family | 61,109 | false | false | The tripartite ATP-independent periplasmic (TRAP) transporters are substrate-binding protein (SBP)-dependent secondary transporters found in prokaryotes. They consist of a substrate-binding protein (SBP) of the DctP or TAXI families and two integral membrane proteins that form the DctQ and DctM protein families [ ]. Th... | [
"GO:0055085"
] | [
"transmembrane transport"
] | [
"biological_process"
] | 1 | [
"PFAM",
"PANTHER"
] | [
"PF03480",
"PTHR33376"
] | [
"DctP",
""
] | [
61093,
60773
] | 2 | [
"GP"
] | [
"GenProp0176"
] | [
"GP:GenProp0176"
] | 1 | [
"2cex",
"2cey",
"2hpg",
"2hzk",
"2hzl",
"2pfy",
"2pfz",
"2v4c",
"2vpn",
"2vpo",
"2wx9",
"2wyk",
"2wyp",
"2xa5",
"2xwi",
"2xwk",
"2xwo",
"2xwv",
"2xxk",
"2zzv",
"2zzw",
"2zzx",
"3b50",
"3fxb",
"3gyy",
"3u65",
"4di3",
"4di4",
"4ln5",
"4mag",
"4mco",
"4mev"... | 143 | [
"PUB00039993",
"PUB00049841",
"PUB00078592",
"PUB00078596"
] | [
"16702222",
"18702523",
"20584082",
"10708364"
] | [
"Conservation of structure and mechanism in primary and secondary transporters exemplified by SiaP, a sialic acid binding virulence factor from Haemophilus influenzae.",
"1.55 A structure of the ectoine binding protein TeaA of the osmoregulated TRAP-transporter TeaABC from Halomonas elongata.",
"Tripartite ATP-... | [
2006,
2008,
2011,
2000
] | 4 | [] | [
"IPR004682",
"IPR026289"
] | 0 | 2 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Sym plasmid",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
117,
59763,
115,
1,
1104,
9
] | 6 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | TRAP transporter solute receptor DctP | TRAP transporter solute receptor DctP | DctP_fam | 2 |
IPR018391 | 18,391 | Pyrrolo-quinoline quinone beta-propeller repeat | PQQ_b-propeller_rpt | Repeat | 61,183 | false | false | Pyrrolo-quinoline quinone (PQQ) is a redox coenzyme, which serves as a cofactor for a number of enzymes (quinoproteins) and particularly for some bacterial dehydrogenases [ , , ]. A number of bacterial quinoproteins belong to this family. Enzymes in this group contain repeats composing a β propeller. | [] | [] | [] | 0 | [
"SMART"
] | [
"SM00564"
] | [
"PQQ"
] | [
61183
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-CEL-1169408",
"R-CEL-381042",
"R-CEL-381070",
"R-CEL-9833482",
"R-DDI-381070",
"R-DME-1169408",
"R-DME-381042",
"R-DME-9833482",
"R-HSA-381070",
"R-HSA-9760173",
"R-MMU-381070",
"R-SCE-381070",
"R-SPO-381070"
] | [
"REACTOME:R-CEL-1169408",
"REACTOME:R-CEL-381042",
"REACTOME:R-CEL-381070",
"REACTOME:R-CEL-9833482",
"REACTOME:R-DDI-381070",
"REACTOME:R-DME-1169408",
"REACTOME:R-DME-381042",
"REACTOME:R-DME-9833482",
"REACTOME:R-HSA-381070",
"REACTOME:R-HSA-9760173",
"REACTOME:R-MMU-381070",
"REACTOME:R-SC... | 13 | [
"1flg",
"1g72",
"1h4i",
"1h4j",
"1kb0",
"1kv9",
"1lrw",
"1w6s",
"1yiq",
"2ad6",
"2ad7",
"2ad8",
"2be1",
"2d0v",
"2hz6",
"2yh3",
"2yms",
"3hxj",
"3p1l",
"3prw",
"3q54",
"3q7m",
"3q7n",
"3q7o",
"4aah",
"4cvb",
"4cvc",
"4hdj",
"4imm",
"4mae",
"4mh1",
"4pk1"... | 186 | [
"PUB00000066",
"PUB00005344",
"PUB00094370"
] | [
"2549854",
"2572081",
"18838797"
] | [
"Quinoproteins, enzymes with pyrrolo-quinoline quinone as cofactor.",
"PQQ, the elusive coenzyme.",
"A tightly bound quinone functions in the ubiquinone reaction sites of quinoprotein alcohol dehydrogenase of an acetic acid bacterium, Gluconobacter suboxydans."
] | [
1989,
1989,
2008
] | 3 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
3878,
42521,
13593,
21,
1170
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Schizosaccharomyces pombe (s... | [
7,
3,
6,
7,
2,
14,
13,
7,
15,
1,
2,
22
] | 12 | true | Repeat | Pyrrolo-quinoline quinone beta-propeller repeat | Pyrrolo-quinoline quinone beta-propeller repeat | PQQ_b-propeller_rpt | 3 |
IPR018392 | 18,392 | LysM domain | LysM | Domain | 159,669 | false | false | The LysM (lysin motif) domain is a small globular domain, approximately 40 amino acids long. It is a widespread protein module involved in binding peptidoglycan in bacteria and chitin in eukaryotes. The domain was originally identified in enzymes that degrade bacterial cell walls [ ], but proteins involved in many othe... | [] | [] | [] | 0 | [
"PFAM",
"PROFILE",
"SMART",
"CDD"
] | [
"PF01476",
"PS51782",
"SM00257",
"cd00118"
] | [
"LysM",
"LYSM",
"LysM",
"LysM"
] | [
139097,
148198,
128201,
145755
] | 4 | [] | [] | [] | 0 | [
"1e0g",
"1y7m",
"2djp",
"2l9y",
"2mkx",
"2mpw",
"2mtz",
"3jc8",
"3jc9",
"3zqd",
"4a1i",
"4a1j",
"4a1k",
"4a52",
"4b8v",
"4b9h",
"4eby",
"4ebz",
"4pxv",
"4s3j",
"4s3k",
"4uz2",
"4uz3",
"4xcm",
"5bum",
"5c8o",
"5c8p",
"5c8q",
"5jcd",
"5jce",
"5k2l",
"5ls2"... | 78 | [
"PUB00001727",
"PUB00019876",
"PUB00082420",
"PUB00155726"
] | [
"1352512",
"10369758",
"15120137",
"34716271"
] | [
"Modular design of the Enterococcus hirae muramidase-2 and Streptococcus faecalis autolysin.",
"Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer.",
"Specific recognition of bacteria by plant LysM domain receptor kinases.",
"Kinetic proofreading of ... | [
1992,
1999,
2004,
2021
] | 4 | [] | [
"IPR014248",
"IPR020012",
"IPR056563"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Viruses",
"unclassified sequences"
] | [
72,
119469,
37640,
832,
1656
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
47,
11,
19,
24,
8,
15,
18,
8,
51,
28,
83
] | 11 | true | Domain | LysM domain | LysM domain | LysM | 2 |
IPR018393 | 18,393 | NADH-plastoquinone oxidoreductase, chain 5 subgroup | NADHpl_OxRdtase_5_subgr | Family | 69,117 | false | false | NADH-plastoquinone oxidoreductase chain 5 is part of the NADH-ubiquinone oxidoreductase (complex I), which catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane [ ]: NADH + ubiquinone = NAD(+) + ubiquinol | [
"GO:0008137",
"GO:0042773"
] | [
"NADH dehydrogenase (ubiquinone) activity",
"ATP synthesis coupled electron transport"
] | [
"molecular_function",
"biological_process"
] | 2 | [
"NCBIFAM"
] | [
"TIGR01974"
] | [
"NDH_I_L"
] | [
69117
] | 1 | [
"EC",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"7.1.1.-",
"R-DRE-611105",
"R-GGA-5419276",
"R-GGA-611105",
"R-GGA-6799198",
"R-HSA-5419276",
"R-HSA-611105",
"R-HSA-6799198",
"R-HSA-9837999",
"R-MMU-5419276",
"R-MMU-611105",
"R-MMU-6799198",
"R-RNO-5419276",
"R-RNO-611105",
"R-RNO-6799198",
"R-SSC-5419276",
"R-SSC-611105",
"R-SS... | [
"EC:7.1.1.-",
"REACTOME:R-DRE-611105",
"REACTOME:R-GGA-5419276",
"REACTOME:R-GGA-611105",
"REACTOME:R-GGA-6799198",
"REACTOME:R-HSA-5419276",
"REACTOME:R-HSA-611105",
"REACTOME:R-HSA-6799198",
"REACTOME:R-HSA-9837999",
"REACTOME:R-MMU-5419276",
"REACTOME:R-MMU-611105",
"REACTOME:R-MMU-6799198"... | 18 | [
"3rko",
"4he8",
"4hea",
"5gpn",
"5gup",
"5lc5",
"5ldw",
"5ldx",
"5lnk",
"5o31",
"5xtc",
"5xtd",
"5xth",
"5xti",
"6g2j",
"6g72",
"6gcs",
"6hum",
"6i0d",
"6i1p",
"6khi",
"6khj",
"6l7o",
"6l7p",
"6nbq",
"6nbx",
"6nby",
"6q8o",
"6q8w",
"6q8x",
"6q9b",
"6qa9"... | 295 | [
"PUB00005074"
] | [
"1470679"
] | [
"The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains."
] | [
1992
] | 1 | [
"IPR003945"
] | [] | 1 | 0 | 1 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences"
] | [
534,
18360,
49757,
466
] | 4 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Zea mays"
] | [
14,
1,
1,
1613,
11,
1,
5,
9,
7
] | 9 | true | Family | NADH-plastoquinone oxidoreductase, chain 5 subgroup | NADH-plastoquinone oxidoreductase, chain 5 subgroup | NADHpl_OxRdtase_5_subgr | 1 |
IPR018394 | 18,394 | Cryptochrome/DNA photolyase class 1, conserved site, C-terminal | DNA_photolyase_1_CS_C | Conserved_site | 20,185 | false | false | This entry represents a number of conserved sequence regions found in the C-terminal region of the class 1 cryptochrome/DNA photolyase. The cryptochrome and photolyase families consist of structurally related flavin adenine dinucleotide (FAD) proteins that use the absorption of blue light to accomplish different tasks.... | [] | [] | [] | 0 | [
"PROSITE",
"PROSITE"
] | [
"PS00394",
"PS00691"
] | [
"DNA_PHOTOLYASES_1_1",
"DNA_PHOTOLYASES_1_2"
] | [
18452,
11858
] | 2 | [
"EC"
] | [
"4.1.99.3"
] | [
"EC:4.1.99.3"
] | 1 | [
"1dnp",
"1iqr",
"1iqu",
"1np7",
"1owl",
"1owm",
"1own",
"1owo",
"1owp",
"1qnf",
"1tez",
"1u3c",
"1u3d",
"2e0i",
"2j07",
"2j08",
"2j09",
"4u63",
"6k8i",
"6k8k",
"6kii",
"6lz3",
"6lz7",
"6m79",
"6x24",
"7x0x",
"7x0y",
"9lpg"
] | 28 | [
"PUB00001269",
"PUB00076729",
"PUB00076730",
"PUB00163231"
] | [
"7813451",
"25910181",
"26352435",
"22066008"
] | [
"A new class of DNA photolyases present in various organisms including aplacental mammals.",
"Binding of Substrate Locks the Electrochemistry of CRY-DASH into DNA Repair.",
"Evolutionary History of the Photolyase/Cryptochrome Superfamily in Eukaryotes.",
"A photolyase-like protein from Agrobacterium tumefacie... | [
1994,
2015,
2015,
2011
] | 4 | [] | [] | 0 | 0 | null | [
"Archaea",
"Bacteria",
"Eukaryota",
"Nucleocytoviricota",
"unclassified sequences"
] | [
590,
15023,
4210,
16,
346
] | 5 | [
"Arabidopsis thaliana",
"Danio rerio",
"Escherichia coli (strain K12)",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Saccharomyces cerevisiae (strain ATCC 204508 / S288c)",
"Zea mays"
] | [
22,
1,
1,
1,
13,
1,
32
] | 7 | true | Conserved_site | Cryptochrome/DNA photolyase class 1, conserved site, C-terminal | Cryptochrome/DNA photolyase class 1, conserved site, C-terminal | DNA_photolyase_1_CS_C | 7 |
IPR018395 | 18,395 | 2-keto-3-deoxygluconate permease, subgroup | 2keto-3dGluconate_permease_sub | Family | 934 | false | false | This family includes the characterised 2-Keto-3-Deoxygluconate transporters from Bacillus subtilis and Erwinia chrysanthemi. There are homologues of this protein found in both Gram-positive and Gram-negative bacteria. In E. chrysanthemi, a phytopathogenic bacterium, degraded pectin products from plant cell walls are tr... | [
"GO:0015649",
"GO:0008643",
"GO:0046411",
"GO:0016020"
] | [
"2-keto-3-deoxygluconate:proton symporter activity",
"carbohydrate transport",
"2-keto-3-deoxygluconate transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"NCBIFAM"
] | [
"TIGR00793"
] | [
"kdgT"
] | [
934
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00043309",
"PUB00043310"
] | [
"2684787",
"3571157"
] | [
"Nucleotide sequence of the Erwinia chrysanthemi gene encoding 2-keto-3-deoxygluconate permease.",
"2-keto-3-deoxygluconate transport system in Erwinia chrysanthemi."
] | [
1989,
1987
] | 2 | [
"IPR004684"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"human gut metagenome"
] | [
933,
1
] | 2 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | 2-keto-3-deoxygluconate permease, subgroup | 2-keto-3-deoxygluconate permease, subgroup | 2keto-3dGluconate_permease_sub | 8 |
IPR018396 | 18,396 | Lysosomal-associated transmembrane protein, 4A/5 | LAPTM_4A/5 | Family | 1,225 | false | false | The lysosome associated protein transmembrane (LAPTM) family is comprised of three members: LAPTM5, LAPTM4a and LAPTM4b; they are lysosome-associated transmembrane proteins, found in mammals, insects and nematodes. This entry represents LAPTM4 alpha (LAPTM4A) and LAPTM45. LAPTM4A regulates the intracellular compartment... | [
"GO:0016020"
] | [
"membrane"
] | [
"cellular_component"
] | 1 | [
"NCBIFAM"
] | [
"TIGR00799"
] | [
"mtp"
] | [
1225
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00055012",
"PUB00055013",
"PUB00055014"
] | [
"11980562",
"10519401",
"19787053"
] | [
"Lysosome-associated protein transmembrane 4 alpha (LAPTM4 alpha) requires two tandemly arranged tyrosine-based signals for sorting to lysosomes.",
"Mouse transporter protein, a membrane protein that regulates cellular multidrug resistance, is localized to lysosomes.",
"Lysosomal-associated protein multispannin... | [
2002,
1999,
2009
] | 3 | [
"IPR004687"
] | [] | 1 | 0 | 1 | [
"Euteleostomi"
] | [
1225
] | 1 | [
"Danio rerio",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
1,
8,
19,
8
] | 4 | true | Family | Lysosomal-associated transmembrane protein, 4A/5 | Lysosomal-associated transmembrane protein, 4A/5 | LAPTM_4A/5 | 6 |
IPR018402 | 18,402 | Malonate/sodium symporter MadM subunit, N-terminal | Mal/Na_symporter_MadM_N | Domain | 1,513 | false | false | This entry represent the N-terminal domain of the malonate/sodium symporter MadM subunit The MSS family includes the monobasic malonate:Na+ symporter of Malonomonas rubra. It consists of two integral membrane proteins, MadL and MadM [ ].The transporter is believed to catalyze the electroneutral reversible uptake of H+-... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF03818"
] | [
"MadM"
] | [
1513
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00060976"
] | [
"9573154"
] | [
"Identification of an Na+-dependent malonate transporter of Malonomonas rubra and its dependence on two separate genes."
] | [
1998
] | 1 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"ecological metagenomes"
] | [
1501,
2,
10
] | 3 | [] | [] | 0 | true | Domain | Malonate/sodium symporter MadM subunit, N-terminal | Malonate/sodium symporter MadM subunit, N-terminal | Mal/Na_symporter_MadM_N | 3 |
IPR018403 | 18,403 | Silicon transporter, Cylindrotheca fusiformis | Silicon_transpt_CYLFU | Family | 6 | false | false | Marine diatoms such as Cylindrotheca fusiformis encode at least six silicon transport protein homologues which exhibit similar size and topology. One characterised member of the family (Sit1) functions in the energy-dependent uptake of either silicic acid [Si(OH)4] or silicate [Si(OH)3O-] by a Na + symport mechanism [ ... | [] | [] | [] | 0 | [
"NCBIFAM"
] | [
"TIGR00811"
] | [
"sit"
] | [
6
] | 1 | [] | [] | [] | 0 | [] | 0 | [
"PUB00062323"
] | [
"9894919"
] | [
"Characterization of a silicon transporter gene family in Cylindrotheca fusiformis: sequences, expression analysis, and identification of homologs in other diatoms."
] | [
1998
] | 1 | [
"IPR004693"
] | [] | 1 | 0 | 1 | [
"Cylindrotheca fusiformis"
] | [
6
] | 1 | [] | [] | 0 | true | Family | Silicon transporter, Cylindrotheca fusiformis | Silicon transporter, Cylindrotheca fusiformis | Silicon_transpt_CYLFU | 6 |
IPR018422 | 18,422 | Cation/H+ exchanger, CPA1 family | Cation/H_exchanger_CPA1 | Family | 52,516 | false | false | This entry represents the cation:proton antiporter family 1 (CPA1), which includes Na+/H+ exchangers and Na+(K+,Li+,Rb+)/H+ exchangers. Sodium proton exchangers (NHEs) constitute a large family of integral membrane protein transporters that are responsible for the counter-transport of protons and sodium ions across lip... | [
"GO:0015385",
"GO:0006812",
"GO:1902600",
"GO:0016020"
] | [
"sodium:proton antiporter activity",
"monoatomic cation transport",
"proton transmembrane transport",
"membrane"
] | [
"molecular_function",
"biological_process",
"biological_process",
"cellular_component"
] | 4 | [
"PANTHER"
] | [
"PTHR10110"
] | [
""
] | [
52516
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-2160916",
"R-BTA-425986",
"R-CEL-2160916",
"R-CEL-425986",
"R-DDI-425986",
"R-HSA-2160916",
"R-HSA-2672351",
"R-HSA-425986",
"R-HSA-5619052",
"R-HSA-5619092",
"R-MMU-2160916",
"R-MMU-425986",
"R-RNO-2160916",
"R-RNO-425986",
"R-SCE-425986",
"R-SPO-425986"
] | [
"REACTOME:R-BTA-2160916",
"REACTOME:R-BTA-425986",
"REACTOME:R-CEL-2160916",
"REACTOME:R-CEL-425986",
"REACTOME:R-DDI-425986",
"REACTOME:R-HSA-2160916",
"REACTOME:R-HSA-2672351",
"REACTOME:R-HSA-425986",
"REACTOME:R-HSA-5619052",
"REACTOME:R-HSA-5619092",
"REACTOME:R-MMU-2160916",
"REACTOME:R-... | 16 | [
"2mdf",
"6z3y",
"6z3z",
"7dsv",
"7dsw",
"7dsx",
"7x2u",
"7y3e",
"8hya",
"8iwo",
"8j2m",
"8jd9",
"8jda",
"8otq",
"8otw",
"8otx",
"8pcz",
"8pd2",
"8pd3",
"8pd5",
"8pd7",
"8pd8",
"8pd9",
"8pdu",
"8pdv",
"8pvr",
"8pxb",
"8u6z",
"8u71",
"8u73",
"8u75",
"8u7d"... | 45 | [
"PUB00001715",
"PUB00002996",
"PUB00003039",
"PUB00044828",
"PUB00044829",
"PUB00044830",
"PUB00044831",
"PUB00044832",
"PUB00044833",
"PUB00044834"
] | [
"9537504",
"9278382",
"9507001",
"12027219",
"12502567",
"16734752",
"17071327",
"16513813",
"11187762",
"17218973"
] | [
"Comparative molecular analysis of Na+/H+ exchangers: a unified model for Na+/H+ antiport?",
"Na+/H+ exchangers of mammalian cells.",
"Identification of a mitochondrial Na+/H+ exchanger.",
"The Na+/H+ exchanger gene family.",
"Multiple modes of regulation of Na+/H+ exchangers.",
"Na+/H+ exchangers and the... | [
1998,
1997,
1998,
2002,
2002,
2006,
2006,
2006,
2000,
2006
] | 10 | [] | [
"IPR004705",
"IPR004709",
"IPR018410"
] | 0 | 3 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"unclassified sequences",
"uncultured Caudovirales phage"
] | [
119,
22748,
29533,
114,
2
] | 5 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Escherichia coli (strain K12)",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",... | [
59,
15,
26,
28,
1,
39,
30,
1,
26,
40,
1,
1,
142
] | 13 | true | Family | Cation/H+ exchanger, CPA1 family | Cation/H+ exchanger, CPA1 family | Cation/H_exchanger_CPA1 | 6 |
IPR018445 | 18,445 | Putative phosphate transport regulator | Put_Phosphate_transp_reg | Family | 11,541 | false | false | This family includes prokaryotic proteins of unknown function, as well as a protein annotated as the pit accessory protein from Rhizobium meliloti (Sinorhizobium meliloti) ( ). However, while it has been hypothesised that this protein may play a role in orthophosphate transport (Pit stands for phosphate transport), its... | [] | [] | [] | 0 | [
"PFAM"
] | [
"PF01865"
] | [
"PhoU_div"
] | [
11541
] | 1 | [] | [] | [] | 0 | [
"2iiu",
"2olt",
"3l39"
] | 3 | [
"PUB00005722"
] | [
"8013901"
] | [
"Second site mutations specifically suppress the Fix- phenotype of Rhizobium meliloti ndvF mutations on alfalfa: identification of a conditional ndvF-dependent mucoid colony phenotype."
] | [
1994
] | 1 | [] | [
"IPR002727"
] | 0 | 1 | 0 | [
"Archaea",
"Bacteria",
"Eukaryota",
"Kukulkanvirus",
"unclassified sequences"
] | [
748,
10514,
7,
2,
270
] | 5 | [] | [] | 0 | true | Family | Putative phosphate transport regulator | Putative phosphate transport regulator | Put_Phosphate_transp_reg | 1 |
IPR018446 | 18,446 | Corticotropin-releasing factor conserved site | Corticotropin-releasing_fac_CS | Conserved_site | 1,554 | false | false | Corticotropin-releasing factor (CRF) (corticoliberin) [ ] is a hormone from the hypothalamus that regulates the release of corticotropin (ACTH) from the pituitary gland. CRF is evolutionary related to a number of other active peptides which are listed below. Urocortin (Ucn) [ ], a brain mammalian peptide with corticotr... | [] | [] | [] | 0 | [
"PROSITE"
] | [
"PS00511"
] | [
"CRF"
] | [
1554
] | 1 | [
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME",
"REACTOME"
] | [
"R-BTA-373080",
"R-BTA-418555",
"R-HSA-373080",
"R-HSA-418555",
"R-HSA-422085",
"R-HSA-9022702",
"R-MMU-373080",
"R-MMU-418555",
"R-RNO-373080",
"R-SSC-373080",
"R-SSC-418555"
] | [
"REACTOME:R-BTA-373080",
"REACTOME:R-BTA-418555",
"REACTOME:R-HSA-373080",
"REACTOME:R-HSA-418555",
"REACTOME:R-HSA-422085",
"REACTOME:R-HSA-9022702",
"REACTOME:R-MMU-373080",
"REACTOME:R-MMU-418555",
"REACTOME:R-RNO-373080",
"REACTOME:R-SSC-373080",
"REACTOME:R-SSC-418555"
] | 11 | [
"2l27",
"2rme",
"2rmf",
"6p9x",
"6pb0",
"6pb1",
"7try",
"7ts0"
] | 8 | [
"PUB00004223",
"PUB00004505",
"PUB00004937"
] | [
"7477349",
"7991460",
"2200028"
] | [
"Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor.",
"Isolation and characterization of a diuretic peptide common to the house fly and stable fly.",
"Evolutionary aspects of corticotropin releasing hormones."
] | [
1995,
1994,
1990
] | 3 | [] | [] | 0 | 0 | null | [
"Opisthokonta",
"Pseudomonadota",
"human gut metagenome"
] | [
1551,
2,
1
] | 3 | [
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Rattus norvegicus"
] | [
3,
2,
3,
2,
4
] | 5 | true | Conserved_site | Corticotropin-releasing factor conserved site | Corticotropin-releasing factor conserved site | Corticotropin-releasing_fac_CS | 4 |
IPR018448 | 18,448 | Sec-independent protein translocase protein TatB | TatB | Family | 12,294 | false | false | This entry represents Sec-independent protein translocase protein TatB (TatB) and similar proteins predominantly found in Proteobacteria. TatB is essential for the secretion of large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. It may form an oligomeric bindi... | [
"GO:0008320",
"GO:0043953",
"GO:0016020"
] | [
"protein transmembrane transporter activity",
"protein transport by the Tat complex",
"membrane"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"HAMAP",
"NCBIFAM"
] | [
"MF_00237",
"TIGR01410"
] | [
"TatB",
"tatB"
] | [
10805,
11196
] | 2 | [
"GP",
"GP"
] | [
"GenProp0127",
"GenProp1136"
] | [
"GP:GenProp0127",
"GP:GenProp1136"
] | 2 | [
"2mi2",
"9dzz",
"9e01",
"9e02",
"9e04",
"9e06"
] | 6 | [
"PUB00007662",
"PUB00007663",
"PUB00099913",
"PUB00099914"
] | [
"9649434",
"10652088",
"31341014",
"20926683"
] | [
"Overlapping functions of components of a bacterial Sec-independent protein export pathway.",
"The Tat protein export pathway.",
"Surface-exposed domains of TatB involved in the structural and functional assembly of the Tat translocase in <i>Escherichia coli</i>.",
"TatB functions as an oligomeric binding sit... | [
1998,
2000,
2019,
2010
] | 4 | [
"IPR003369"
] | [] | 1 | 0 | 1 | [
"Bacteria",
"Candidatus Methanofastidiosum methylothiophilum",
"Eukaryota",
"unclassified sequences"
] | [
12118,
1,
9,
166
] | 4 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Sec-independent protein translocase protein TatB | Sec-independent protein translocase protein TatB | TatB | 6 |
IPR018450 | 18,450 | Romo1/Mgr2 | Romo1/Mgr2 | Family | 3,580 | false | false | This entry includes a group of mitochondrial proteins, including reactive oxygen species modulator 1 (Romo1) from animals and Mgr2 from fungi. | [] | [] | [] | 0 | [
"PFAM",
"PANTHER",
"SMART"
] | [
"PF10247",
"PTHR28525",
"SM01378"
] | [
"Romo1",
"",
"Romo1"
] | [
3566,
3394,
3521
] | 3 | [] | [] | [] | 0 | [
"9j9b"
] | 1 | [
"PUB00044856",
"PUB00044857",
"PUB00044858",
"PUB00044859",
"PUB00078817"
] | [
"16842742",
"18836179",
"18313394",
"17537404",
"22613836"
] | [
"A novel protein, Romo1, induces ROS production in the mitochondria.",
"Replicative senescence induced by Romo1-derived reactive oxygen species.",
"A critical role for Romo1-derived ROS in cell proliferation.",
"Drug resistance to 5-FU linked to reactive oxygen species modulator 1.",
"Mgr2 promotes coupling... | [
2006,
2008,
2008,
2007,
2012
] | 5 | [] | [] | 0 | 0 | null | [
"Eukaryota",
"Rhodobacterales"
] | [
3577,
3
] | 2 | [
"Arabidopsis thaliana",
"Caenorhabditis elegans",
"Danio rerio",
"Drosophila melanogaster",
"Homo sapiens",
"Mus musculus",
"Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)",
"Oryza sativa subsp. japonica",
"Rattus norvegicus",
"Saccharomyces cerevisiae (strai... | [
2,
2,
1,
1,
1,
1,
1,
1,
3,
1,
1,
6
] | 12 | true | Family | Romo1/Mgr2 | Romo1/Mgr2 | Romo1/Mgr2 | 2 |
IPR018451 | 18,451 | NAF/FISL domain | NAF/FISL_domain | Domain | 15,109 | false | false | The NAF domain is a 24 amino acid domain that is found in a plant-specific subgroup of serine-threonine protein kinases (CIPKs), that interact with calcineurin B-like calcium sensor proteins (CBLs). Whereas the N-terminal part of CIPKs comprises a conserved catalytic domain typical of Ser-Thr kinases, the much less con... | [
"GO:0007165"
] | [
"signal transduction"
] | [
"biological_process"
] | 1 | [
"PROFILE"
] | [
"PS50816"
] | [
"NAF"
] | [
15109
] | 1 | [
"EC"
] | [
"2.7.11.1"
] | [
"EC:2.7.11.1"
] | 1 | [
"2ehb",
"2zfd",
"4czt",
"4czu",
"4d28"
] | 5 | [
"PUB00007298",
"PUB00018279"
] | [
"11230129",
"11402167"
] | [
"The NAF domain defines a novel protein-protein interaction module conserved in Ca2+-regulated kinases.",
"Molecular characterization of functional domains in the protein kinase SOS2 that is required for plant salt tolerance."
] | [
2001,
2001
] | 2 | [] | [] | 0 | 0 | null | [
"Bacteria",
"Eukaryota",
"freshwater metagenome"
] | [
11,
15096,
2
] | 3 | [
"Arabidopsis thaliana",
"Oryza sativa subsp. japonica",
"Zea mays"
] | [
105,
112,
207
] | 3 | true | Domain | NAF/FISL domain | NAF/FISL domain | NAF/FISL_domain | 8 |
IPR018454 | 18,454 | Phosphotransferase system, glucitol/sorbitol-specific IIA component, subgroup | PTS_IIA_glucitol/sorbitol_sub | Family | 131 | false | false | The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS) [ , ] is a major carbohydrate transport system in bacteria. The PTS catalyses the phosphorylation of incoming sugar substrates and coupled with translocation across the cell membrane, makes the PTS a link between the uptake and metabolism of sugars... | [
"GO:0008982",
"GO:0009401",
"GO:0005737"
] | [
"protein-N(PI)-phosphohistidine-sugar phosphotransferase activity",
"phosphoenolpyruvate-dependent sugar phosphotransferase system",
"cytoplasm"
] | [
"molecular_function",
"biological_process",
"cellular_component"
] | 3 | [
"NCBIFAM"
] | [
"TIGR00849"
] | [
"gutA"
] | [
131
] | 1 | [
"GP"
] | [
"GenProp0119"
] | [
"GP:GenProp0119"
] | 1 | [] | 0 | [
"PUB00000073",
"PUB00002162",
"PUB00003612",
"PUB00017027",
"PUB00017028"
] | [
"2197982",
"1537788",
"8246840",
"7815935",
"11361063"
] | [
"The bacterial phosphoenolpyruvate: glycose phosphotransferase system.",
"Proposed uniform nomenclature for the proteins and protein domains of the bacterial phosphoenolpyruvate: sugar phosphotransferase system.",
"Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.",
"The bacterial phosp... | [
1990,
1992,
1993,
1994,
2001
] | 5 | [
"IPR004716"
] | [] | 1 | 0 | 1 | [
"Bacteria"
] | [
131
] | 1 | [
"Escherichia coli (strain K12)"
] | [
1
] | 1 | true | Family | Phosphotransferase system, glucitol/sorbitol-specific IIA component, subgroup | Phosphotransferase system, glucitol/sorbitol-specific IIA component, subgroup | PTS_IIA_glucitol/sorbitol_sub | 1 |
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