LiteFold/InterPro · Datasets at Hugging Face

IPR018455

18,455

Phosphotransferase system, sorbose subfamily IIB component, subgroup

PTS_IIB_sorbose-sp_subgr

Family

3,621

false

Bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains [ ]. The Man family is unique in several respects among PTS permease families: It is the only PTS family in wh...

[ "GO:0008982", "GO:0009401", "GO:0005737" ]

[ "protein-N(PI)-phosphohistidine-sugar phosphotransferase activity", "phosphoenolpyruvate-dependent sugar phosphotransferase system", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "NCBIFAM" ]

[ "TIGR00854" ]

[ "pts-sorbose" ]

[ 3621 ]

1

[ "GP" ]

[ "GenProp0119" ]

[ "GP:GenProp0119" ]

1

[ "1ble", "1nrz", "1vsq", "2jzh", "2jzn", "2jzo", "3eye" ]

7

[ "PUB00017031", "PUB00080194", "PUB00080195" ]

[ "12662934", "10393270", "11532441" ]

[ "Crystal structure of the IIB(Sor) domain of the sorbose permease from Klebsiella pneumoniae solved to 1.75A resolution.", "Structure/function studies on the bacterial carbohydrate transporters, enzymes II, of the phosphoenolpyruvate-dependent phosphotransferase system.", "Carbohydrate transporters of the bacte...

[ 2003, 1999, 2001 ]

3

[]

0

null

[ "Bacteria", "Opisthokonta", "metagenomes" ]

[ 3613, 3, 5 ]

3

[ "Escherichia coli (strain K12)" ]

[ 3 ]

1

true

Family

Phosphotransferase system, sorbose subfamily IIB component, subgroup

PTS_IIB_sorbose-sp_subgr

3

IPR018456

18,456

PTR2 family proton/oligopeptide symporter, conserved site

PTR2_symporter_CS

Conserved_site

39,635

false

The transport of peptides into cells is a well-documented biological phenomenon which is accomplished by specific, energy-dependent transporters found in a number of organisms as diverse as bacteria and humans. The PTR family of proteins is distinct from the ABC-type peptide transporters and was uncovered by sequence a...

[ "GO:0022857", "GO:0006857", "GO:0016020" ]

[ "transmembrane transporter activity", "oligopeptide transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PROSITE", "PROSITE" ]

[ "PS01022", "PS01023" ]

[ "PTR2_1", "PTR2_2" ]

[ 24783, 29132 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-427975", "R-BTA-6798695", "R-BTA-9860276", "R-CEL-427975", "R-DME-427975", "R-HSA-427975", "R-HSA-6798695", "R-HSA-9860276", "R-MMU-427975", "R-MMU-6798695", "R-MMU-9860276", "R-RNO-427975", "R-RNO-6798695", "R-RNO-9860276", "R-SCE-427975", "R-SCE-6798695", "R-SPO-427975", "...

[ "REACTOME:R-BTA-427975", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-9860276", "REACTOME:R-CEL-427975", "REACTOME:R-DME-427975", "REACTOME:R-HSA-427975", "REACTOME:R-HSA-6798695", "REACTOME:R-HSA-9860276", "REACTOME:R-MMU-427975", "REACTOME:R-MMU-6798695", "REACTOME:R-MMU-9860276", "REACTOME:R-R...

18

[ "2xut", "4aps", "4d2b", "4d2c", "4d2d", "4ikv", "4ikw", "4ikx", "4iky", "4ikz", "4oh3", "4q65", "4uvm", "4w6v", "4xni", "4xnj", "5a2n", "5a2o", "5d58", "5d59", "5d6k", "5mmt", "5oxk", "5oxl", "5oxm", "5oxn", "5oxo", "5oxp", "5oxq", "6ei3", "6eia", "6exs"...

87

[ "PUB00003872", "PUB00005425" ]

[ "7476181", "7817396" ]

[ "The PTR family: a new group of peptide transporters.", "The POT family of transport proteins." ]

[ 1995, 1994 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacterium", "Siphoviridae sp. ctCCX1", "metagenomes" ]

[ 18586, 20923, 4, 1, 121 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (s...

[ 88, 3, 15, 9, 4, 14, 19, 51, 21, 1, 1, 81 ]

12

true

Conserved_site

PTR2 family proton/oligopeptide symporter, conserved site

PTR2_symporter_CS

2

IPR018457

18,457

LacY/RafB permease family, conserved site

LacY/RafB_perm_fam_CS

Conserved_site

1,099

false

This entry represents two conserved regions that correspond to cytoplasmic loops in the integral membrane proteins of the LacY family. In bacteria there are a number of families of transport proteins, including symporters and antiporters, that mediate the intake of a variety of sugars with the concomitant uptake of hyd...

[]

0

[ "PROSITE", "PROSITE" ]

[ "PS00896", "PS00897" ]

[ "LACY_1", "LACY_2" ]

[ 946, 898 ]

2

[]

0

[ "1pv6", "1pv7", "2cfp", "2cfq", "2v8n", "2y5y", "4oaa", "4zyr", "5gxb", "6c9w", "6vbg" ]

11

[ "PUB00003754", "PUB00005398", "PUB00088052" ]

[ "1435727", "8438231", "9209070" ]

[ "Characterization of a chromosomally encoded, non-PTS metabolic pathway for sucrose utilization in Escherichia coli EC3132.", "A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport.", "A melibiose transporter and an operon containing its gene in Enterobacter cloacae." ]

[ 1992, 1993, 1997 ]

3

[]

0

null

[ "Bacteria", "Podospora aff. communis PSN243", "metagenomes" ]

[ 1095, 1, 3 ]

3

[ "Escherichia coli (strain K12)" ]

[ 2 ]

1

true

Conserved_site

LacY/RafB permease family, conserved site

LacY/RafB_perm_fam_CS

3

IPR018459

18,459

RII binding domain

RII-bd_1

Domain

969

false

This domain is found is a wide variety of AKAPs (A kinase anchoring proteins) [ ].

[]

0

[ "PFAM" ]

[ "PF10522" ]

[ "RII_binding_1" ]

[ 969 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-193648", "R-HSA-416482", "R-HSA-8980692", "R-HSA-9013026", "R-HSA-9013106", "R-HSA-9013405", "R-HSA-9035034", "R-MMU-9013405", "R-MMU-9035034", "R-RNO-983231" ]

[ "REACTOME:R-HSA-193648", "REACTOME:R-HSA-416482", "REACTOME:R-HSA-8980692", "REACTOME:R-HSA-9013026", "REACTOME:R-HSA-9013106", "REACTOME:R-HSA-9013405", "REACTOME:R-HSA-9035034", "REACTOME:R-MMU-9013405", "REACTOME:R-MMU-9035034", "REACTOME:R-RNO-983231" ]

10

[ "2drn", "8s8o" ]

2

[ "PUB00011239" ]

[ "10319321" ]

[ "Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein." ]

[ 1999 ]

1

[]

0

null

[ "Tetrapoda" ]

[ 969 ]

1

[ "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 13, 16, 13 ]

3

true

Domain

RII binding domain

RII-bd_1

8

IPR018460

18,460

Batten's disease protein Cln3, subgroup

Battenin_disease_Cln3_subgr

Family

2,510

false

Batten's disease, the juvenile variant of neuronal ceroid lipofuscionosis (NCL), is a recessively inherited disorder affecting children of 5-10 years of age. The disease is characterised by progressive loss of vision, seizures and psychomotor disturbances. Biochemically, the disease is characterised by lysosomal accumu...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PIRSF" ]

[ "PIRSF015974" ]

[ "CLN3_BTN1" ]

[ 2510 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9845576", "R-MMU-9845576", "R-SCE-9845576", "R-SPO-9845576" ]

[ "REACTOME:R-HSA-9845576", "REACTOME:R-MMU-9845576", "REACTOME:R-SCE-9845576", "REACTOME:R-SPO-9845576" ]

4

[]

0

[ "PUB00009450", "PUB00009451", "PUB00009452", "PUB00009453", "PUB00009454", "PUB00009455", "PUB00009456", "PUB00009457", "PUB00009458" ]

[ "7553855", "2142158", "9311735", "10191115", "10191114", "1482112", "7716512", "10191112", "9384607" ]

[ "Isolation of a novel gene underlying Batten disease, CLN3. The International Batten Disease Consortium.", "Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells.", "Spectrum of mutations in the Batten disease gene, CLN3.", "Expression studies of CLN3 protein (batt...

[ 1995, 1990, 1997, 1999, 1999, 1992, 1995, 1999, 1998 ]

9

[ "IPR003492" ]

[]

1

0

1

[ "Eukaryota" ]

[ 2510 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 4, 1, 2, 9, 3, 1, 5, 1, 1 ]

9

true

Family

Batten's disease protein Cln3, subgroup

Battenin_disease_Cln3_subgr

8

IPR018461

18,461

Na+/H+ antiporter, NhaC-like, C-terminal

Na/H_Antiport_NhaC-like_C

Domain

26,333

false

This entry represents the C-terminal domain of a group of integral membrane proteins, some of which are Na/H antiporters [ , ].

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF03553" ]

[ "Na_H_antiporter" ]

[ 26333 ]

1

[]

0

[]

0

[ "PUB00019907", "PUB00094158" ]

[ "9190799", "17937670" ]

[ "Role of the nhaC-encoded Na+/H+ antiporter of alkaliphilic Bacillus firmus OF4.", "Expression of the Na+/H+ antiporter gene (g1-nhaC) of alkaliphilic Bacillus sp. G1 in Escherichia coli." ]

[ 1997, 2007 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ct3z32", "unclassified sequences" ]

[ 1053, 24748, 264, 1, 267 ]

5

[]

0

true

Domain

Na+/H+ antiporter, NhaC-like, C-terminal

Na/H_Antiport_NhaC-like_C

4

IPR018463

18,463

Centromere protein Cenp-F, N-terminal

Centromere_CenpF_N

Domain

1,185

false

Mitosin or centromere-associated protein-F (Cenp-F) is a coiled-coil protein that dimerizes and localizes to diverse subcellular locations, including microtubule plus-ends, mitochondria, nuclear pores, and kinetochores [ ]. It localizes to kinetochores during mitosis and is then rapidly degraded after mitosis. It is re...

[]

0

[ "PFAM" ]

[ "PF10481" ]

[ "CENP-F_N" ]

[ 1185 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-141444", "R-HSA-156711", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-68877", "R-HSA-9648025" ]

[ "REACTOME:R-HSA-141444", "REACTOME:R-HSA-156711", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-HSA-68877", "REACTOME:R-HSA-9648025" ]

7

[]

0

[ "PUB00053248", "PUB00094135", "PUB00094136", "PUB00094137" ]

[ "17600710", "32207772", "26101217", "28701340" ]

[ "Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes.", "CENP-F stabilizes kinetochore-microtubule attachments and limits dynein stripping of corona cargoes.", "Centromere protein F includes two sites that couple efficiently to depolymerizing microtubules.", "CENP-F couples cargo t...

[ 2007, 2020, 2015, 2017 ]

4

[]

0

null

[ "Opisthokonta" ]

[ 1185 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 7, 2, 7, 1 ]

4

true

Domain

Centromere protein Cenp-F, N-terminal

Centromere_CenpF_N

7

IPR018464

18,464

Centromere protein O

CENP-O

Family

2,757

false

This entry represents centromere protein O (CENP-O) and its homologues in yeasts, Mcm21 and Mal2. Human CENP-O is a component of the CENPA-CAD (nucleosome distal) complex, which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation [ , , , ]. Mcm21 is a component of the inner k...

[ "GO:0051382", "GO:0000776" ]

[ "kinetochore assembly", "kinetochore" ]

[ "biological_process", "cellular_component" ]

2

[ "PFAM", "PANTHER" ]

[ "PF09496", "PTHR14582" ]

[ "CENP-O", "" ]

[ 2584, 2599 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-141444", "R-BTA-2467813", "R-BTA-2500257", "R-BTA-5663220", "R-BTA-606279", "R-BTA-68877", "R-BTA-9648025", "R-HSA-141444", "R-HSA-2467813", "R-HSA-2500257", "R-HSA-5663220", "R-HSA-606279", "R-HSA-68877", "R-HSA-9648025", "R-MMU-141444", "R-MMU-2467813", "R-MMU-2500257", "R...

[ "REACTOME:R-BTA-141444", "REACTOME:R-BTA-2467813", "REACTOME:R-BTA-2500257", "REACTOME:R-BTA-5663220", "REACTOME:R-BTA-606279", "REACTOME:R-BTA-68877", "REACTOME:R-BTA-9648025", "REACTOME:R-HSA-141444", "REACTOME:R-HSA-2467813", "REACTOME:R-HSA-2500257", "REACTOME:R-HSA-5663220", "REACTOME:R-H...

28

[ "3zxu", "5mu3", "6nuw", "6qld", "6qle", "6qlf", "7pb8", "7pkn", "7qoo", "7r5s", "7r5v", "7xhn", "7xho", "7ywx", "7yyh", "8ovw", "8ovx", "8ow0", "8ow1" ]

19

[ "PUB00011383", "PUB00019931", "PUB00044193", "PUB00044194", "PUB00044860", "PUB00044862", "PUB00067771", "PUB00148996", "PUB00158502", "PUB00161563" ]

[ "12242294", "14633972", "16079914", "16622419", "16622420", "18007590", "22561346", "9987135", "16932742", "36085283" ]

[ "The mal2p protein is an essential component of the fission yeast centromere.", "Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes.", "Molecular analysis of kinetochore architecture in fission yeast.", "The human CENP-A centromeric nucleosome-associated complex.", "The CENP-H...

[ 2002, 2003, 2005, 2006, 2006, 2007, 2012, 1999, 2006, 2022 ]

10

[]

0

null

[ "Eukaryota", "Vibrio cholerae" ]

[ 2755, 2 ]

2

[ "Arabidopsis thaliana", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (st...

[ 9, 3, 1, 4, 1, 4, 6, 1, 1, 8 ]

10

true

Family

Centromere protein O

CENP-O

7

IPR018466

18,466

Cell wall synthesis protein KRE9/Knh1-like, N-terminal

Kre9/Knh1-like_N

Domain

9,048

false

This domain is found at the N-terminal of a group of cell wall synthesis proteins, such as Knh1 and Kre9 from budding yeast, involved in cell wall beta 1,6-glucan synthesis. Kre9 is also involved in cell wall beta-glucan assembly [ ]. In Saccharomyces cerevisiae, a kre9 null mutation leads to severe growth defects, abe...

[]

0

[ "PFAM" ]

[ "PF10342" ]

[ "Kre9_KNH" ]

[ 9048 ]

1

[]

0

[]

0

[ "PUB00044867", "PUB00053934", "PUB00053935", "PUB00066799", "PUB00066800", "PUB00067887" ]

[ "17383119", "8462845", "8413233", "8810042", "19220866", "16204227" ]

[ "Le.MAPK and its interacting partner, Le.DRMIP, in fruiting body development in Lentinula edodes.", "A mutational analysis of killer toxin resistance in Saccharomyces cerevisiae identifies new genes involved in cell wall (1-->6)-beta-glucan synthesis.", "The yeast KRE9 gene encodes an O glycoprotein involved in...

[ 2007, 1993, 1993, 1996, 2009, 2005 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 14, 277, 8677, 80 ]

4

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea mays" ]

[ 4, 2, 4, 1 ]

4

true

Domain

Cell wall synthesis protein KRE9/Knh1-like, N-terminal

Kre9/Knh1-like_N

1

IPR018467

18,467

CO/COL/TOC1, conserved site

CCT_CS

Conserved_site

7,516

false

The short CCT (CO, COL, TOC1) motif is found in a number of plant proteins, including Constans (CO), Constans-like (COL) and TOC1. The CCT motif is about 45 amino acids long and contains a putative nuclear localisation signal within the second half of the CCT motif [ ]. The CCT motif is found in the Arabidopsis circadi...

[]

0

[ "PFAM" ]

[ "PF09425" ]

[ "Jas_motif" ]

[ 7516 ]

1

[]

0

[ "3ogk", "3ogl", "3ogm", "4rs9", "4ywc", "4yz6", "5t0q", "8t2i" ]

8

[ "PUB00012285" ]

[ "10926537" ]

[ "Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota" ]

[ 7516 ]

1

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 70, 27, 153 ]

3

true

Conserved_site

CO/COL/TOC1, conserved site

CCT_CS

1

IPR018468

18,468

SFR1/Mei5 family

SFR1/Mei5

Family

1,207

false

This entry includes Mei5 from budding yeasts and SFR1 from animals and fission yeasts. Although the fission yeast Swi5-Sfr1 complex is critical for homologous recombination repair, the budding yeast counterpart Sae3-Mei5 complex is meiosis-specific, interacts with Dmc1, and promotes assembly of Dmc1 on meiotic chromoso...

[]

0

[ "PFAM" ]

[ "PF10376" ]

[ "Mei5" ]

[ 1207 ]

1

[]

0

[ "3viq" ]

1

[ "PUB00044868", "PUB00090451" ]

[ "15620352", "21252223" ]

[ "A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1.", "The role of the human SWI5-MEI5 complex in homologous recombination repair." ]

[ 2004, 2011 ]

2

[]

[ "IPR042429" ]

0

1

0

[ "Eukaryota" ]

[ 1207 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 1, 2, 4, 1, 1 ]

6

true

Family

SFR1/Mei5 family

SFR1/Mei5

4

IPR018469

18,469

Dual oxidase maturation factor

Dual_oxidase_maturation_fac

Family

2,721

false

DuoxA (Dual oxidase maturation factor) is the essential protein necessary for the final release of DUOX2 (an NADPH:O2 oxidoreductase flavoprotein) from the endoplasmic reticulum. Dual oxidases (DUOX1 and DUOX2) constitute the catalytic core of the hydrogen peroxide generator, which generates H2O2 at the apical membrane...

[ "GO:0015031", "GO:0005789", "GO:0016020" ]

[ "protein transport", "endoplasmic reticulum membrane", "membrane" ]

[ "biological_process", "cellular_component", "cellular_component" ]

3

[ "PFAM", "PANTHER" ]

[ "PF10204", "PTHR31158" ]

[ "DuoxA", "" ]

[ 2718, 2690 ]

2

[]

0

[ "6wxr", "6wxu", "6wxv", "7d3e", "7d3f" ]

5

[ "PUB00044237" ]

[ "16651268" ]

[ "Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent." ]

[ 2006 ]

1

[]

0

null

[ "Eukaryota" ]

[ 2721 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 2, 12, 6, 5 ]

6

true

Family

Dual oxidase maturation factor

Dual_oxidase_maturation_fac

1

IPR018470

18,470

Periplasmic metal-binding protein Tp34-type

Metal-bd_Tp34-typ

Family

2,257

false

This is a family of metal-binding periplasmic proteins. Tp34 has been classified together with other proteins in a group of uncharacterised proteins probably involved in high affinity Fe2+ transport. However, the structural and functional aspects of this group of proteins remain undetermined. Tp34 may bind zinc and the...

[]

0

[ "PFAM", "PIRSF" ]

[ "PF10634", "PIRSF017018" ]

[ "Iron_transport", "Tp34" ]

[ 2257, 1590 ]

2

[]

0

[ "2o6c", "2o6d", "2o6e", "2o6f", "3lzl", "3lzn", "3lzo", "3lzp", "3lzq", "3lzr", "3nrp", "3nrq", "3pjl", "3pjn", "4nwn", "5i0v", "5i0w", "5i0x", "5i0y", "6wed", "6wee", "6wef", "7r3p", "7r3s", "7r4u", "7r4v", "7r4z", "7r5e", "7r5g", "7r5p", "8t7k", "8t7l"...

35

[ "PUB00042117", "PUB00088244" ]

[ "17192261", "23042995" ]

[ "Crystal structure of the Tp34 (TP0971) lipoprotein of treponema pallidum: implications of its metal-bound state and affinity for human lactoferrin.", "Biophysical and bioinformatic analyses implicate the Treponema pallidum Tp34 lipoprotein (Tp0971) in transition metal homeostasis." ]

[ 2007, 2012 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "unclassified sequences" ]

[ 2054, 5, 183, 15 ]

4

[]

0

true

Family

Periplasmic metal-binding protein Tp34-type

Metal-bd_Tp34-typ

1

IPR018472

18,472

Large ribosomal subunit protein mL64

Ribosomal_mL64

Family

1,153

false

This entry represents the large ribosomal subunit protein mL64, also known as Growth arrest and DNA damage-inducible proteins-interacting protein 1. Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additi...

[ "GO:0005634" ]

[ "nucleus" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF10147", "PTHR31761" ]

[ "CR6_interact", "" ]

[ 1141, 1119 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5368286", "R-HSA-5389840", "R-HSA-5419276", "R-HSA-9937383", "R-MMU-5389840", "R-MMU-5419276", "R-MMU-9937383", "R-RNO-5389840", "R-RNO-5419276", "R-RNO-9937383" ]

[ "REACTOME:R-HSA-5368286", "REACTOME:R-HSA-5389840", "REACTOME:R-HSA-5419276", "REACTOME:R-HSA-9937383", "REACTOME:R-MMU-5389840", "REACTOME:R-MMU-5419276", "REACTOME:R-MMU-9937383", "REACTOME:R-RNO-5389840", "REACTOME:R-RNO-5419276", "REACTOME:R-RNO-9937383" ]

10

[ "3j7y", "3j9m", "4v1a", "5aj4", "5ool", "5oom", "6gaw", "6gb2", "6i9r", "6nu2", "6nu3", "6vlz", "6vmi", "6ydp", "6ydw", "6zm5", "6zm6", "6zs9", "6zsa", "6zsb", "6zsc", "6zsd", "6zse", "6zsg", "7a5f", "7a5g", "7a5h", "7a5i", "7a5j", "7a5k", "7l08", "7l20"...

90

[ "PUB00044211" ]

[ "12716909" ]

[ "CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle." ]

[ 2003 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 1153 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 2, 1, 2, 1, 2 ]

6

true

Family

Large ribosomal subunit protein mL64

Ribosomal_mL64

8

IPR018473

18,473

Hermes trasposase, DNA-binding domain

Hermes_transposase_DNA-db

Domain

3,364

false

This domain confers specific DNA-binding on Hermes transposase [ ].

[]

0

[ "PFAM" ]

[ "PF10683" ]

[ "DBD_Tnp_Hermes" ]

[ 3364 ]

1

[]

0

[ "2bw3", "4d1q", "6dww", "6dwy", "6dwz", "6dx0", "8edg", "8sjd" ]

8

[ "PUB00039784" ]

[ "16041385" ]

[ "Molecular architecture of a eukaryotic DNA transposase." ]

[ 2005 ]

1

[]

0

null

[ "Eukaryota" ]

[ 3364 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 2, 2, 1, 2, 7 ]

5

true

Domain

Hermes trasposase, DNA-binding domain

Hermes_transposase_DNA-db

5

IPR018474

18,474

Uncharacterised protein family YqaI

Uncharacterised_Yqai

Family

316

false

The hypothetical protein YqaI is expressed in Bacillus species. It forms a homo-dimer, with each monomer containing an α helix and four β strands.

[]

0

[ "PFAM" ]

[ "PF09466" ]

[ "Yqai" ]

[ 316 ]

1

[]

0

[ "2dsm" ]

1

[]

0

[]

0

null

[ "Bacillati", "Viruses" ]

[ 308, 8 ]

2

[]

0

true

Family

Uncharacterised protein family YqaI

Uncharacterised_Yqai

4

IPR018475

18,475

Luciferase, helical bundle domain

Luciferase_hlx-bundle_domain

Domain

70

false

This domain is found associated with the the catalytic domain of dinoflagellate luciferase. Luciferase is involved in catalysing the light emitting reaction in bioluminescence. This domain has a three helix bundle structure that holds four important histidines that are thought to play a role in the pH regulation of the...

[]

0

[ "PFAM" ]

[ "PF10284" ]

[ "Luciferase_3H" ]

[ 70 ]

1

[]

0

[ "1vpr" ]

1

[ "PUB00032115" ]

[ "15665092" ]

[ "Crystal structure of a pH-regulated luciferase catalyzing the bioluminescent oxidation of an open tetrapyrrole." ]

[ 2005 ]

1

[]

0

null

[ "Sar" ]

[ 70 ]

1

[]

0

true

Domain

Luciferase, helical bundle domain

Luciferase_hlx-bundle_domain

9

IPR018476

18,476

Glycerophosphoryl diester phosphodiesterase, membrane domain

GlyceroP-diester-Pdiesterase_M

Domain

3,413

false

Members of this family comprise the membrane domain of the prokaryotic enzyme glycerophosphoryl diester phosphodiesterase [ ].

[]

0

[ "PFAM" ]

[ "PF10110" ]

[ "GPDPase_memb" ]

[ 3413 ]

1

[]

0

[]

0

[ "PUB00044869" ]

[ "1851953" ]

[ "Characterization of two genes, glpQ and ugpQ, encoding glycerophosphoryl diester phosphodiesterases of Escherichia coli." ]

[ 1991 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Trichuris trichiura", "metagenomes" ]

[ 19, 3378, 1, 15 ]

4

[]

0

true

Domain

Glycerophosphoryl diester phosphodiesterase, membrane domain

GlyceroP-diester-Pdiesterase_M

4

IPR018477

18,477

Bicaudal-D protein

BICD

Family

5,095

false

Bicaudal-D (BicD) is a family of motor adaptor proteins consist of three coiled-coiled domains. BicD plays an essential for the correct localization of maternal mRNAs in Drosophila's oocyte [ ] and functions as a regulator of the Golgi to ER retrograde transport in mammalian cells [ ]. BicD was suggested to be a linker...

[ "GO:0008093", "GO:0070840" ]

[ "cytoskeletal anchor activity", "dynein complex binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "PANTHER" ]

[ "PF09730", "PTHR31233" ]

[ "BicD", "" ]

[ 4867, 5073 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-6811436", "R-DME-6811436", "R-HSA-6811436", "R-MMU-6811436" ]

[ "REACTOME:R-CEL-6811436", "REACTOME:R-DME-6811436", "REACTOME:R-HSA-6811436", "REACTOME:R-MMU-6811436" ]

4

[ "4bl6", "4ytd", "6ofp", "6pse", "6tzw" ]

5

[ "PUB00044870", "PUB00087207", "PUB00087208", "PUB00087209" ]

[ "19018277", "28215293", "19754453", "17827179" ]

[ "BicaudalD actively regulates microtubule motor activity in lipid droplet transport.", "Neuronal Roles of the Bicaudal D Family of Motor Adaptors.", "Bicaudal-D and its role in cargo sorting by microtubule-based motors.", "Rab6 and the secretory pathway affect oocyte polarity in Drosophila." ]

[ 2008, 2017, 2009, 2007 ]

4

[]

0

null

[ "Kocuria dechangensis", "Metazoa" ]

[ 1, 5094 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 19, 5, 7, 9, 14 ]

6

true

Family

Bicaudal-D protein

BICD

1

IPR018478

18,478

Sporulation transcription regulator WhiA, N-terminal domain

Sporu_reg_WhiA_N_dom

Domain

9,169

false

This entry represents the N-terminal domain of sporulation transcription factor WhiA [ ]. This domain is related to the LAGLIDADG homing endonuclease domain, while the C-terminal domain of WhiA is predicted to be a DNA binding helix-turn-helix domain [ , ].

[]

0

[ "PFAM" ]

[ "PF10298" ]

[ "WhiA_N" ]

[ 9169 ]

1

[]

0

[ "3hyi", "3hyj", "8dy7", "8dy9" ]

4

[ "PUB00044539", "PUB00044736", "PUB00066662" ]

[ "17603302", "10986251", "19836336" ]

[ "Bacterial DUF199/COG1481 proteins including sporulation regulator WhiA are distant homologs of LAGLIDADG homing endonucleases that retained only DNA binding.", "WhiA, a protein of unknown function conserved among gram-positive bacteria, is essential for sporulation in Streptomyces coelicolor A3(2).", "The stru...

[ 2007, 2000, 2009 ]

3

[]

0

null

[ "Bacteria", "Streptococcus phage MM1", "metagenomes" ]

[ 9019, 1, 149 ]

3

[]

0

true

Domain

Sporulation transcription regulator WhiA, N-terminal domain

Sporu_reg_WhiA_N_dom

5

IPR018479

18,479

Monopolin complex subunit Lrs4/Mde4

Lrs4/Mde4

Family

68

false

Monopolin is a protein complex, originally identified in Saccharomyces cerevisiae (Baker's yeast), that is required for the segregation of homologous centromeres to opposite poles of a dividing cell during meiosis I [ ]. The orthologous complex in Schizosaccharomyces pombe (Fission yeast) is not required for meiosis I ...

[]

0

[ "PFAM" ]

[ "PF10422" ]

[ "LRS4" ]

[ 68 ]

1

[]

0

[ "3n7n" ]

1

[ "PUB00044337", "PUB00044338", "PUB00044339" ]

[ "11163190", "12689592", "17627824" ]

[ "Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis i.", "Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I.", "The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent mer...

[ 2000, 2003, 2007 ]

3

[]

0

null

[ "Eukaryota" ]

[ 68 ]

1

[ "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

Monopolin complex subunit Lrs4/Mde4

Lrs4/Mde4

5

IPR018480

18,480

Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site

PNAcMuramoyl-5peptid_Trfase_CS

Conserved_site

33,726

false

Phospho-N-acetylmuramoyl-pentapeptide-transferase ( ) (MraY) is a bacterial enzyme responsible for the formation of the first lipid intermediate of the cell wall peptidoglycan synthesis [ ]. It catalyses the formation of undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide from UDP-MurNAc-pentapeptide and undecapr...

[]

0

[ "PFAM", "PROSITE", "PROSITE" ]

[ "PF10555", "PS01347", "PS01348" ]

[ "MraY_sig1", "MRAY_1", "MRAY_2" ]

[ 20127, 21394, 33035 ]

3

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC" ]

[ "2.7.8.13", "PWY-5265", "PWY-6385", "PWY-6470", "PWY-6471" ]

[ "EC:2.7.8.13", "METACYC:PWY-5265", "METACYC:PWY-6385", "METACYC:PWY-6470", "METACYC:PWY-6471" ]

5

[ "4j72", "5ckr", "5jnq", "6oyh", "6oyz", "6oz6", "8cxr", "8g01", "8g02", "8tlu", "9b70", "9b71" ]

12

[ "PUB00006616" ]

[ "10564498" ]

[ "Topological analysis of the MraY protein catalysing the first membrane step of peptidoglycan synthesis." ]

[ 1999 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Methanobacteriota", "Siphoviridae sp. ctBLh2", "unclassified sequences" ]

[ 32344, 527, 53, 1, 801 ]

5

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)" ]

[ 6, 1 ]

2

true

Conserved_site

Phospho-N-acetylmuramoyl-pentapeptide transferase, conserved site

PNAcMuramoyl-5peptid_Trfase_CS

4

IPR018482

18,482

Zinc finger C4H2 domain-containing protein

Znf-C4H2

Family

2,215

false

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt b...

[]

0

[ "PFAM", "PANTHER" ]

[ "PF10146", "PTHR31058" ]

[ "zf-C4H2", "" ]

[ 2163, 2177 ]

2

[]

0

[ "9p3z" ]

1

[ "PUB00014077", "PUB00035804", "PUB00035805", "PUB00035806", "PUB00035807", "PUB00035812" ]

[ "12665246", "17210253", "15963892", "15718139", "10529348", "11179890" ]

[ "Zinc fingers--folds for many occasions.", "Sticky fingers: zinc-fingers as protein-recognition motifs.", "Multiple modes of RNA recognition by zinc finger proteins.", "Zinc finger proteins: getting a grip on RNA.", "Zinc finger peptides for the regulation of gene expression.", "Zinc finger proteins: new ...

[ 2002, 2007, 2005, 2005, 1999, 2001 ]

6

[]

0

null

[ "Eukaryota" ]

[ 2215 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 1, 1, 3, 2, 3 ]

6

true

Family

Zinc finger C4H2 domain-containing protein

Znf-C4H2

6

IPR018483

18,483

Carbohydrate kinase, FGGY, conserved site

Carb_kinase_FGGY_CS

Conserved_site

62,690

false

FGGY carbohydrate kinases carry out ATP-dependent phosphorylation on one out of at least nine distinct sugar substrates [ ]. These enzymes include L-ribulokinase ( ) (gene araB); Erythriol kinase ( ) (gene eryA); L-fucolokinase ( ) (gene fucK); gluconokinase ( ) (gene gntK); glycerol kinase ( ) (gene glpK); xylulokinas...

[ "GO:0016773", "GO:0005975" ]

[ "phosphotransferase activity, alcohol group as acceptor", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PROSITE", "PROSITE" ]

[ "PS00445", "PS00933" ]

[ "FGGY_KINASES_2", "FGGY_KINASES_1" ]

[ 56235, 38531 ]

2

[ "EC", "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.1", "2.7.1.30", "PWY-4261", "R-BTA-75109", "R-CEL-75109", "R-DDI-75109", "R-HSA-75109", "R-MMU-75109", "R-RNO-75109", "R-SCE-75109" ]

[ "EC:2.7.1", "EC:2.7.1.30", "METACYC:PWY-4261", "REACTOME:R-BTA-75109", "REACTOME:R-CEL-75109", "REACTOME:R-DDI-75109", "REACTOME:R-HSA-75109", "REACTOME:R-MMU-75109", "REACTOME:R-RNO-75109", "REACTOME:R-SCE-75109" ]

10

[ "1bo5", "1bot", "1bu6", "1bwf", "1gla", "1glb", "1glc", "1gld", "1gle", "1glf", "1glj", "1gll", "1r59", "1xup", "2d4w", "2dpn", "2itm", "2nlx", "2w40", "2w41", "2zf5", "3d7e", "3ezw", "3flc", "3g25", "3gbt", "3ge1", "3h3n", "3h3o", "3h45", "3h46", "3hz6"...

63

[ "PUB00056209", "PUB00080793" ]

[ "17274596", "22215998" ]

[ "Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria.", "The FGGY carbohydrate kinase family: insights into the evolution of functional specificities." ]

[ 2007, 2011 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Inoviridae sp. ctwVE22", "unclassified sequences" ]

[ 590, 51668, 9624, 1, 807 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 5, 1, 14, 12, 4, 10, 11, 1, 3, 23, 1, 5 ]

12

true

Conserved_site

Carbohydrate kinase, FGGY, conserved site

Carb_kinase_FGGY_CS

7

IPR018484

18,484

Carbohydrate kinase FGGY, N-terminal

FGGY_N

Domain

106,536

false

This entry represents the N-terminal domain of these proteins. It adopts a ribonuclease H-like fold and is structurally related to the C-terminal domain [ , ]. FGGY carbohydrate kinases carry out ATP-dependent phosphorylation on one out of at least nine distinct sugar substrates [ ]. These enzymes include L-ribulokinas...

[ "GO:0016301", "GO:0005975" ]

[ "kinase activity", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF00370" ]

[ "FGGY_N" ]

[ 106536 ]

1

[ "EC", "EC", "GP", "GP", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.1", "2.7.1.30", "GenProp0457", "GenProp0458", "GenProp1476", "PWY-4261", "R-BTA-5661270", "R-BTA-75109", "R-CEL-5661270", "R-CEL-75109", "R-DDI-75109", "R-HSA-5661270", "R-HSA-71336", "R-HSA-75109", "R-MMU-5661270", "R-MMU-71336", "R-MMU-75109", "R-RNO-5661270", "R-RNO-75109...

[ "EC:2.7.1", "EC:2.7.1.30", "GP:GenProp0457", "GP:GenProp0458", "GP:GenProp1476", "METACYC:PWY-4261", "REACTOME:R-BTA-5661270", "REACTOME:R-BTA-75109", "REACTOME:R-CEL-5661270", "REACTOME:R-CEL-75109", "REACTOME:R-DDI-75109", "REACTOME:R-HSA-5661270", "REACTOME:R-HSA-71336", "REACTOME:R-HSA...

22

[ "1bo5", "1bot", "1bu6", "1bwf", "1gla", "1glb", "1glc", "1gld", "1gle", "1glf", "1glj", "1gll", "1r59", "1xup", "2cgj", "2cgk", "2cgl", "2d4w", "2dpn", "2itm", "2nlx", "2uyt", "2w40", "2w41", "2zf5", "3d7e", "3ezw", "3flc", "3g25", "3gbt", "3ge1", "3gg4"...

82

[ "PUB00005161", "PUB00019551", "PUB00056209", "PUB00080793" ]

[ "8430315", "9843423", "17274596", "22215998" ]

[ "Structure of the regulatory complex of Escherichia coli IIIGlc with glycerol kinase.", "Crystal structure of a complex of Escherichia coli glycerol kinase and an allosteric effector fructose 1,6-bisphosphate.", "Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria.", ...

[ 1993, 1998, 2007, 2011 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Inoviridae sp. ctwVE22", "unclassified sequences" ]

[ 810, 83436, 20940, 1, 1349 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 24, 4, 27, 16, 7, 28, 22, 3, 8, 39, 4, 1, 8 ]

13

true

Domain

Carbohydrate kinase FGGY, N-terminal

FGGY_N

8

IPR018485

18,485

Carbohydrate kinase FGGY, C-terminal

FGGY_C

Domain

105,034

false

This entry represents the C-terminal domain of these proteins. It adopts a ribonuclease H-like fold and is structurally related to the N-terminal domain [ , ]. FGGY carbohydrate kinases carry out ATP-dependent phosphorylation on one out of at least nine distinct sugar substrates [ ]. These enzymes include L-ribulokinas...

[ "GO:0016301", "GO:0005975" ]

[ "kinase activity", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF02782" ]

[ "FGGY_C" ]

[ 105034 ]

1

[ "EC", "EC", "GP", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "2.7.1", "2.7.1.30", "GenProp1476", "PWY-4261", "R-BTA-5661270", "R-BTA-75109", "R-CEL-5661270", "R-CEL-75109", "R-DDI-75109", "R-HSA-5661270", "R-HSA-75109", "R-MMU-5661270", "R-MMU-75109", "R-RNO-5661270", "R-RNO-75109", "R-SCE-5661270", "R-SCE-75109", "R-SPO-5661270" ]

[ "EC:2.7.1", "EC:2.7.1.30", "GP:GenProp1476", "METACYC:PWY-4261", "REACTOME:R-BTA-5661270", "REACTOME:R-BTA-75109", "REACTOME:R-CEL-5661270", "REACTOME:R-CEL-75109", "REACTOME:R-DDI-75109", "REACTOME:R-HSA-5661270", "REACTOME:R-HSA-75109", "REACTOME:R-MMU-5661270", "REACTOME:R-MMU-75109", "...

18

[ "1bo5", "1bot", "1bu6", "1bwf", "1gla", "1glb", "1glc", "1gld", "1gle", "1glf", "1glj", "1gll", "1r59", "1xup", "2cgj", "2cgk", "2cgl", "2d4w", "2dpn", "2itm", "2nlx", "2uyt", "2w40", "2w41", "2zf5", "3d7e", "3ezw", "3flc", "3g25", "3gbt", "3ge1", "3gg4"...

88

[ "PUB00005161", "PUB00019551", "PUB00056209", "PUB00080793" ]

[ "8430315", "9843423", "17274596", "22215998" ]

[ "Structure of the regulatory complex of Escherichia coli IIIGlc with glycerol kinase.", "Crystal structure of a complex of Escherichia coli glycerol kinase and an allosteric effector fructose 1,6-bisphosphate.", "Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria.", ...

[ 1993, 1998, 2007, 2011 ]

4

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Inoviridae sp. ctwVE22", "unclassified sequences" ]

[ 777, 82897, 20058, 1, 1301 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 26, 4, 23, 16, 8, 20, 21, 4, 16, 38, 4, 1, 8 ]

13

true

Domain

Carbohydrate kinase FGGY, C-terminal

FGGY_C

8

IPR018486

18,486

Hemopexin, conserved site

Hemopexin_CS

Conserved_site

14,551

false

Hemopexin ( ) is a serum glycoprotein that binds haem and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation [ ]. Hemopexin prevents haem-mediated oxidative stress. Structurally hemopexin consists of two similar halves of approximately two hundred amino...

[]

0

[ "PROSITE" ]

[ "PS00024" ]

[ "HEMOPEXIN" ]

[ 14551 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.4.24", "R-CFA-1442490", "R-CFA-1474228", "R-CFA-1592389", "R-CFA-2179392", "R-CFA-9009391", "R-GGA-1442490", "R-GGA-1474228", "R-GGA-1592389", "R-GGA-3928665", "R-GGA-9009391", "R-HSA-1433557", "R-HSA-1442490", "R-HSA-1474228", "R-HSA-1592389", "R-HSA-2022090", "R-HSA-210991", "...

[ "EC:3.4.24", "REACTOME:R-CFA-1442490", "REACTOME:R-CFA-1474228", "REACTOME:R-CFA-1592389", "REACTOME:R-CFA-2179392", "REACTOME:R-CFA-9009391", "REACTOME:R-GGA-1442490", "REACTOME:R-GGA-1474228", "REACTOME:R-GGA-1592389", "REACTOME:R-GGA-3928665", "REACTOME:R-GGA-9009391", "REACTOME:R-HSA-14335...

71

[ "1ck7", "1fbl", "1gen", "1gxd", "1hxn", "1itv", "1pex", "1qhu", "1qjs", "1rtg", "1su3", "2clt", "2jxy", "2mqs", "3ba0", "3c7x", "4auo", "4fu4", "4fvl", "4g0d", "6clz", "6cm1", "6o5e", "7rj9", "7txr", "7u68" ]

26

[ "PUB00013983", "PUB00013984", "PUB00013985" ]

[ "14619953", "9572850", "12042069" ]

[ "Structure and evolutionary aspects of matrix metalloproteinases: a brief overview.", "Characterization of the ligand binding activities of vitronectin: interaction of vitronectin with lipids and identification of the binding domains for various ligands using recombinant domains.", "Hemopexin: structure, functi...

[ 2003, 1998, 2002 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales" ]

[ 51, 14498, 2 ]

3

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 24, 9, 54, 55, 61 ]

5

true

Conserved_site

Hemopexin, conserved site

Hemopexin_CS

2

IPR018487

18,487

Hemopexin-like repeats

Hemopexin-like_repeat

Repeat

26,309

false

Hemopexin ( ) is a serum glycoprotein that binds haem and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation [ ]. Hemopexin prevents haem-mediated oxidative stress. Structurally hemopexin consists of two similar halves of approximately two hundred amino...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF00045", "PS51642", "SM00120" ]

[ "Hemopexin", "HEMOPEXIN_2", "HX" ]

[ 24987, 26014, 25789 ]

3

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.4.24", "R-BTA-1433557", "R-BTA-1442490", "R-BTA-1474228", "R-BTA-1592389", "R-BTA-3928665", "R-BTA-6798695", "R-BTA-9009391", "R-CEL-1442490", "R-CEL-1474228", "R-CEL-1592389", "R-CEL-210991", "R-CEL-2168880", "R-CEL-2179392", "R-CEL-3928665", "R-CEL-6798695", "R-CFA-1442490", "...

[ "EC:3.4.24", "REACTOME:R-BTA-1433557", "REACTOME:R-BTA-1442490", "REACTOME:R-BTA-1474228", "REACTOME:R-BTA-1592389", "REACTOME:R-BTA-3928665", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-9009391", "REACTOME:R-CEL-1442490", "REACTOME:R-CEL-1474228", "REACTOME:R-CEL-1592389", "REACTOME:R-CEL-21099...

95

[ "1ck7", "1fbl", "1gen", "1gxd", "1hxn", "1itv", "1pex", "1qhu", "1qjs", "1rtg", "1su3", "2clt", "2jxy", "2mqs", "3ba0", "3c7x", "3lp9", "3oyo", "3s18", "3v6n", "4auo", "4fu4", "4fvl", "4g0d", "4hsd", "4ll2", "4oei", "4rt6", "4yeh", "6clz", "6cm1", "6ix1"...

36

[ "PUB00003374", "PUB00013983", "PUB00013984", "PUB00013985", "PUB00068726" ]

[ "8969305", "14619953", "9572850", "12042069", "20147493" ]

[ "The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain.", "Structure and evolutionary aspects of matrix metalloproteinases: a brief overview.", "Characterization of the ligand binding activities of vitronectin: interaction of vitronectin with lipids and ide...

[ 1996, 2003, 1998, 2002, 2010 ]

5

[]

0

null

[ "Bacteria", "Candidatus Nitrosocosmicus oleophilus", "Eukaryota", "Viruses", "bird metagenome" ]

[ 555, 1, 25744, 8, 1 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus" ]

[ 6, 65, 10, 72, 71, 2, 78 ]

7

true

Repeat

Hemopexin-like repeats

Hemopexin-like_repeat

2

IPR018490

18,490

Cyclic nucleotide-binding domain superfamily

cNMP-bd_dom_sf

Homologous_superfamily

274,663

false

Proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues [ , , ]. The best studied of these proteins is the prokaryotic catabolite gene activator (also known as the cAMP receptor protein) (gene crp) where such a domain is known to be composed of three α-helices and a distinct...

[]

0

[ "SSF" ]

[ "SSF51206" ]

[ "" ]

[ 274663 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-1296072", "R-BTA-163615", "R-BTA-164378", "R-BTA-180024", "R-BTA-2485179", "R-BTA-2514859", "R-BTA-392517", "R-BTA-418457", "R-BTA-432040", "R-BTA-442720", "R-BTA-5610787", "R-BTA-5673001", "R-BTA-9634597", "R-BTA-983231", "R-BTA-9856530", "R-CEL-163615", "R-CEL-164378", "R-...

[ "REACTOME:R-BTA-1296072", "REACTOME:R-BTA-163615", "REACTOME:R-BTA-164378", "REACTOME:R-BTA-180024", "REACTOME:R-BTA-2485179", "REACTOME:R-BTA-2514859", "REACTOME:R-BTA-392517", "REACTOME:R-BTA-418457", "REACTOME:R-BTA-432040", "REACTOME:R-BTA-442720", "REACTOME:R-BTA-5610787", "REACTOME:R-BTA...

187

[ "1cgp", "1cx4", "1ft9", "1g6n", "1hw5", "1i5z", "1i6x", "1j59", "1lb2", "1ne4", "1ne6", "1o3q", "1o3r", "1o3s", "1o3t", "1o5l", "1o7f", "1omi", "1q3e", "1q43", "1q5o", "1rgs", "1rl3", "1run", "1ruo", "1u12", "1vp6", "1wgp", "1zrc", "1zrd", "1zre", "1zrf"...

510

[ "PUB00005543", "PUB00013967", "PUB00013968" ]

[ "1710853", "14638413", "10550204" ]

[ "The cyclic nucleotide-gated channels of vertebrate photoreceptors and olfactory epithelium.", "Phylogeny of the bacterial superfamily of Crp-Fnr transcription regulators: exploiting the metabolic spectrum by controlling alternative gene programs.", "Transcription activation by catabolite activator protein (CAP...

[ 1991, 2003, 1999 ]

3

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 29, 151953, 120729, 5, 1947 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 181, 34, 301, 87, 4, 142, 119, 4, 96, 167, 3, 3, 225 ]

13

true

Homologous_superfamily

Cyclic nucleotide-binding domain superfamily

cNMP-bd_dom_sf

9

IPR018491

18,491

SLC12A transporter, C-terminal

SLC12_C

Domain

22,433

false

This entry represents a domain found in the C-terminal of the solute carrier family 12 (SLC12) members, which are K-Cl cotransporters. The SLC12 family members are predicted to have 12 transmembrane (TM) regions in a central hydrophobic domain, together with hydrophilic N- and C-termini that are likely cytoplasmic. Com...

[ "GO:0022857", "GO:0006811", "GO:0016020" ]

[ "transmembrane transporter activity", "monoatomic ion transport", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM" ]

[ "PF03522" ]

[ "SLC12" ]

[ 22433 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-CEL-426117", "R-DRE-426117", "R-HSA-426117", "R-HSA-5619039", "R-HSA-5619087", "R-HSA-5619104", "R-MMU-426117", "R-RNO-426117" ]

[ "REACTOME:R-CEL-426117", "REACTOME:R-DRE-426117", "REACTOME:R-HSA-426117", "REACTOME:R-HSA-5619039", "REACTOME:R-HSA-5619087", "REACTOME:R-HSA-5619104", "REACTOME:R-MMU-426117", "REACTOME:R-RNO-426117" ]

8

[ "6kkr", "6kkt", "6kku", "6m1y", "6m22", "6m23", "6npj", "6npl", "6pzt", "6ukn", "6vw9", "6vwa", "6y5r", "6y5v", "7ain", "7aio", "7aip", "7aiq", "7air", "7d10", "7d14", "7d8z", "7d90", "7d99", "7mxo", "7n3n", "7ngb", "7s1x", "7s1y", "7s1z", "7sfl", "7smp"...

51

[ "PUB00002956", "PUB00004291", "PUB00044874" ]

[ "8663311", "9930699", "10600773" ]

[ "Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform.", "The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation.", "Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter." ]

[ 1996, 1999, 1999 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 248, 22182, 3 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 5, 23, 50, 12, 40, 37, 1, 6, 43, 1, 29 ]

11

true

Domain

SLC12A transporter, C-terminal

SLC12_C

1

IPR018492

18,492

Ribosomal protein eL8/Nhp2 family

Ribosomal_eL8/Nhp2

Family

15,801

false

This entry includes large ribosomal subunit protein eL8 (in human is also known as L7a and in yeast is also known as L4) [ , , ] and several other ribosomal proteins that have been found to share sequence similarity with eL8/L7a, including Saccharomyces cerevisiae NHP2 [ ]. Ribosomes are the particles that catalyse mRN...

[]

0

[ "PRINTS" ]

[ "PR00881" ]

[ "L7ARS6FAMILY" ]

[ 15801 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-156827", "R-BTA-171319", "R-BTA-1799339", "R-BTA-6791226", "R-BTA-72163", "R-BTA-72689", "R-BTA-72706", "R-BTA-975956", "R-BTA-975957", "R-CEL-156827", "R-CEL-1799339", "R-CEL-6791226", "R-CEL-72689", "R-CEL-72706", "R-CEL-975956", "R-CEL-975957", "R-DDI-156827", "R-DDI-1799...

[ "REACTOME:R-BTA-156827", "REACTOME:R-BTA-171319", "REACTOME:R-BTA-1799339", "REACTOME:R-BTA-6791226", "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72689", "REACTOME:R-BTA-72706", "REACTOME:R-BTA-975956", "REACTOME:R-BTA-975957", "REACTOME:R-CEL-156827", "REACTOME:R-CEL-1799339", "REACTOME:R-CEL-679...

77

[ "1e7k", "1ffk", "1jj2", "1k73", "1k8a", "1k9m", "1kc8", "1kd1", "1kqs", "1m1k", "1m90", "1n8r", "1nji", "1pxw", "1q7y", "1q81", "1q82", "1q86", "1qvf", "1qvg", "1ra4", "1rlg", "1s72", "1sds", "1vq4", "1vq5", "1vq6", "1vq7", "1vq8", "1vq9", "1vqk", "1vql"...

851

[ "PUB00000574", "PUB00003742", "PUB00004372", "PUB00005644", "PUB00007068", "PUB00007069", "PUB00007070" ]

[ "1756182", "2046660", "2183194", "2063628", "11297922", "11290319", "11114498" ]

[ "The organization and expression of the human L7a ribosomal protein gene.", "The organization and expression of the Saccharomyces cerevisiae L4 ribosomal protein genes and their identification as the homologues of the mammalian ribosomal protein gene L7a.", "Ribosomal protein L4 of Saccharomyces cerevisiae: the...

[ 1991, 1991, 1990, 1991, 2001, 2001, 2000 ]

7

[ "IPR050257" ]

[ "IPR001921", "IPR002415", "IPR022481" ]

1

3

0

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 902, 40, 14820, 39 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 21, 3, 4, 6, 13, 8, 2, 15, 39, 4, 3, 56 ]

12

true

Family

Ribosomal protein eL8/Nhp2 family

Ribosomal_eL8/Nhp2

4

IPR018493

18,493

Gas vesicle protein A-like, conserved site

GvpA-like_CS

Conserved_site

5,600

false

This entry represents conserved sequence regions located in the N- and C-terminal domains of Gas vesicle protein A from Streptomyces sp. and similar prokaryotic sequences. Gas vesicles (GVs) are small, hollow, gas filled protein structures found in several cyanobacterial and archaebacterial microorganisms [ , , , ]. Th...

[ "GO:0005198", "GO:0012506" ]

[ "structural molecule activity", "vesicle membrane" ]

[ "molecular_function", "cellular_component" ]

2

[ "PROSITE", "PROSITE" ]

[ "PS00234", "PS00669" ]

[ "GAS_VESICLE_A_1", "GAS_VESICLE_A_2" ]

[ 5249, 3429 ]

2

[]

0

[ "7r1c", "8gbs" ]

2

[ "PUB00000481", "PUB00001807", "PUB00151154", "PUB00151155", "PUB00151157", "PUB00151158" ]

[ "2513809", "1864501", "33711860", "2586485", "37040766", "36868215" ]

[ "Gas vesicle proteins.", "Structure and organization of the gas vesicle gene cluster on the Halobacterium halobium plasmid pNRC100.", "Growth competition between <i>Halobacterium salinarium</i> strain PHH1 and mutants affected in gas vesicle synthesis.", "Expression of two gas vacuole protein genes in Halobac...

[ 1989, 1991, 1997, 1989, 2023, 2023 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes" ]

[ 466, 5121, 10, 3 ]

4

[]

0

true

Conserved_site

Gas vesicle protein A-like, conserved site

GvpA-like_CS

4

IPR018494

18,494

Oxysterol-binding protein, conserved site

Oxysterol-bd_CS

Conserved_site

32,425

false

A number of eukaryotic proteins that seem to be involved with sterol synthesis and/or its regulation have been found [ ] to be evolutionary related. These include mammalian oxysterol-binding protein (OSBP), a protein of about 800 amino-acid residues that binds a variety of oxysterols (oxygenated derivatives of choleste...

[]

0

[ "PROSITE" ]

[ "PS01013" ]

[ "OSBP" ]

[ 32425 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-DDI-1482801", "R-DDI-192105", "R-DDI-9013407", "R-HSA-1482801", "R-HSA-1660661", "R-HSA-192105", "R-HSA-2132295", "R-HSA-9013407", "R-MMU-1482801", "R-MMU-192105", "R-MMU-2132295", "R-MMU-9013407", "R-RNO-192105", "R-RNO-2132295", "R-SCE-1482801", "R-SCE-192105", "R-SPO-1482801", ...

[ "REACTOME:R-DDI-1482801", "REACTOME:R-DDI-192105", "REACTOME:R-DDI-9013407", "REACTOME:R-HSA-1482801", "REACTOME:R-HSA-1660661", "REACTOME:R-HSA-192105", "REACTOME:R-HSA-2132295", "REACTOME:R-HSA-9013407", "REACTOME:R-MMU-1482801", "REACTOME:R-MMU-192105", "REACTOME:R-MMU-2132295", "REACTOME:R...

19

[ "1zht", "1zhw", "1zhx", "1zhy", "1zhz", "1zi7", "3spw", "4b2z", "4f4b", "4fes", "4ic4", "4inq", "4jch", "4ph7", "5h2d", "5wvr", "5zm5", "5zm6", "5zm7", "5zm8", "7cyz", "7dei", "7dej", "7v62", "8p7a", "9hdh", "9hdk" ]

27

[ "PUB00005653", "PUB00100201", "PUB00100202", "PUB00100203", "PUB00100204", "PUB00100205", "PUB00100206", "PUB00100237" ]

[ "8017104", "17428193", "16897474", "15746430", "34283201", "11238399", "29487131", "30051576" ]

[ "A new family of yeast genes implicated in ergosterol synthesis is related to the human oxysterol binding protein.", "The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket.", "Identification and characterization of PiORP1, a Petunia oxys...

[ 1994, 2007, 2006, 2005, 2021, 2001, 2018, 2018 ]

8

[]

0

null

[ "Bacteria", "Eukaryota", "bird metagenome" ]

[ 2, 32422, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 16, 9, 142, 20, 62, 50, 6, 7, 66, 7, 5, 17 ]

12

true

Conserved_site

Oxysterol-binding protein, conserved site

Oxysterol-bd_CS

5

IPR018495

18,495

Succinate dehydrogenase, cytochrome b subunit, conserved site

Succ_DH_cyt_bsu_CS

Conserved_site

10,317

false

Succinate dehydrogenase (SDH) is a membrane-bound complex of two main components: a membrane-extrinsic component composed of an FAD-binding flavoprotein and an iron-sulphur protein, and a hydrophobic component composed of a cytochrome b and a membrane anchor protein. The cytochrome b component is a mono-haem transmembr...

[ "GO:0009055", "GO:0006099", "GO:0016020" ]

[ "electron transfer activity", "tricarboxylic acid cycle", "membrane" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PROSITE", "PROSITE" ]

[ "PS01000", "PS01001" ]

[ "SDH_CYT_1", "SDH_CYT_2" ]

[ 6883, 8361 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-71403", "R-BTA-9854311", "R-HSA-611105", "R-HSA-71403", "R-HSA-9854311", "R-MMU-71403", "R-MMU-9854311", "R-SCE-71403", "R-SSC-71403", "R-SSC-9854311" ]

[ "REACTOME:R-BTA-71403", "REACTOME:R-BTA-9854311", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-71403", "REACTOME:R-HSA-9854311", "REACTOME:R-MMU-71403", "REACTOME:R-MMU-9854311", "REACTOME:R-SCE-71403", "REACTOME:R-SSC-71403", "REACTOME:R-SSC-9854311" ]

10

[ "1nek", "1nen", "1yq3", "1yq4", "1zoy", "1zp0", "2acz", "2fbw", "2h88", "2h89", "2wdq", "2wdr", "2wdv", "2wp9", "2wqy", "2ws3", "2wu2", "2wu5", "3abv", "3ae1", "3ae2", "3ae3", "3ae4", "3ae5", "3ae6", "3ae7", "3ae8", "3ae9", "3aea", "3aeb", "3aec", "3aed"...

66

[ "PUB00002750", "PUB00003349", "PUB00003763", "PUB00152800" ]

[ "1447196", "7616569", "8152421", "37490987" ]

[ "Cytochrome b560 (QPs1) of mitochondrial succinate-ubiquinone reductase. Immunochemistry, cloning, and nucleotide sequencing.", "Complete sequence of the mitochondrial DNA of the rhodophyte Chondrus crispus (Gigartinales). Gene content and genome organization.", "Characterization of the Saccharomyces cerevisiae...

[ 1992, 1995, 1994, 2023 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Haloplanus rubicundus", "unclassified sequences" ]

[ 6597, 3655, 1, 64 ]

4

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 2, 1, 2, 1, 10, 3, 1, 7, 2 ]

9

true

Conserved_site

Succinate dehydrogenase, cytochrome b subunit, conserved site

Succ_DH_cyt_bsu_CS

3

IPR018496

18,496

Pseudouridine synthase, RsuA/RluB/E/F, conserved site

PsdUridine_synth_RsuA/RluB_CS

Conserved_site

51,557

false

Pseudouridine synthases catalyse the isomerisation of uridine to pseudouridine (Psi) in a variety of RNA molecules, and may function as RNA chaperones. Pseudouridine is the most abundant modified nucleotide found in all cellular RNAs. There are four distinct families of pseudouridine synthases that share no global sequ...

[ "GO:0003723", "GO:0016866", "GO:0001522", "GO:0009451" ]

[ "RNA binding", "intramolecular transferase activity", "pseudouridine synthesis", "RNA modification" ]

[ "molecular_function", "molecular_function", "biological_process", "biological_process" ]

4

[ "PROSITE" ]

[ "PS01149" ]

[ "PSI_RSU" ]

[ 51557 ]

1

[ "EC" ]

[ "5.4.99" ]

[ "EC:5.4.99" ]

1

[ "1ksk", "1ksl", "1ksv", "1vio", "2gml", "2olw", "2oml", "3dh3", "4lab", "4lgt", "9cl9" ]

11

[ "PUB00018355", "PUB00037953", "PUB00045922", "PUB00092579" ]

[ "11953756", "16511038", "10529181", "19664587" ]

[ "Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP.", "Structure of the pseudouridine synthase RsuA from Haemophilus influenzae.", "Role of cysteine residues in pseudouridine synthases of different families.", "Enzymatic characterization and mutational studies of TruD--the fifth fa...

[ 2002, 2005, 1999, 2009 ]

4

[]

0

null

[ "Bacteria", "Eukaryota", "Thermoplasmatota", "unclassified sequences" ]

[ 49749, 1164, 7, 637 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 4, 4, 4, 6 ]

4

true

Conserved_site

Pseudouridine synthase, RsuA/RluB/E/F, conserved site

PsdUridine_synth_RsuA/RluB_CS

1

IPR018497

18,497

Peptidase M13, C-terminal domain

Peptidase_M13_C

Domain

39,697

false

This entry represents the C-terminal domain of M13 peptidases. This group of metallopeptidases belong to the MEROPS peptidase family M13 (neprilysin family, clan MA(E)). The M13 family includes neprilysin (neutral endopeptidase, NEP, enkephalinase, CD10, CALLA, ), endothelin-converting enzyme I (ECE-1, ), erythrocyte s...

[ "GO:0004222", "GO:0006508" ]

[ "metalloendopeptidase activity", "proteolysis" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM", "PRINTS" ]

[ "PF01431", "PR00786" ]

[ "Peptidase_M13", "NEPRILYSIN" ]

[ 39656, 33674 ]

2

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.4.24", "R-BTA-375276", "R-CEL-2022377", "R-CEL-5578768", "R-CEL-6798695", "R-DME-2022377", "R-DME-5578768", "R-DME-6798695", "R-HSA-2022377", "R-HSA-375276", "R-HSA-5578768", "R-HSA-6798695", "R-HSA-9927432", "R-MMU-2022377", "R-MMU-375276", "R-MMU-5578768", "R-MMU-6798695", "R-...

[ "EC:3.4.24", "REACTOME:R-BTA-375276", "REACTOME:R-CEL-2022377", "REACTOME:R-CEL-5578768", "REACTOME:R-CEL-6798695", "REACTOME:R-DME-2022377", "REACTOME:R-DME-5578768", "REACTOME:R-DME-6798695", "REACTOME:R-HSA-2022377", "REACTOME:R-HSA-375276", "REACTOME:R-HSA-5578768", "REACTOME:R-HSA-6798695...

21

[ "1dmt", "1r1h", "1r1i", "1r1j", "1y8j", "2qpj", "2yb9", "3dwb", "3zuk", "4cth", "4iuw", "4xbh", "4zr5", "5jmy", "5v48", "6gid", "6row", "6sh1", "6sh2", "6suk", "6svy", "6thp", "6xly", "6xvp", "7k1v", "9eyg", "9kn2" ]

27

[ "PUB00000181", "PUB00001657", "PUB00003579", "PUB00011643", "PUB00080115" ]

[ "3555489", "8099556", "7674922", "11223883", "10849750" ]

[ "Molecular cloning and amino acid sequence of rat enkephalinase.", "Substitution of potential metal-coordinating amino acid residues in the zinc-binding site of endopeptidase-24.11.", "Evolutionary families of metallopeptidases.", "The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and functi...

[ 1987, 1993, 1995, 2001, 2000 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 64, 14064, 25255, 24, 290 ]

5

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 31, 26, 42, 69, 25, 36 ]

6

true

Domain

Peptidase M13, C-terminal domain

Peptidase_M13_C

2

IPR018498

18,498

Peripherin/rom-1, conserved site

Peripherin/rom-1_CS

Conserved_site

1,846

false

Tetraspanins are a distinct family of cell surface proteins, containing four conserved transmembrane domains: a small outer loop (EC1), a larger outer loop (EC2), a small inner loop (IL) and short cytoplasmic tails. They contain characteristic structural features, including 4-6 conserved extracellular cysteine residues...

[ "GO:0007601", "GO:0016020" ]

[ "visual perception", "membrane" ]

[ "biological_process", "cellular_component" ]

2

[ "PROSITE" ]

[ "PS00930" ]

[ "RDS_ROM1" ]

[ 1846 ]

1

[]

0

[ "7zw1" ]

1

[ "PUB00000323", "PUB00004308", "PUB00010633" ]

[ "2372552", "1610568", "12575999" ]

[ "Molecular cloning, primary structure, and orientation of the vertebrate photoreceptor cell protein peripherin in the rod outer segment disk membrane.", "Cloning of the cDNA for a novel photoreceptor membrane protein (rom-1) identifies a disk rim protein family implicated in human retinopathies.", "Functional d...

[ 1990, 1992, 2003 ]

3

[]

0

null

[ "Vertebrata" ]

[ 1846 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 6, 2, 5, 4 ]

4

true

Conserved_site

Peripherin/rom-1, conserved site

Peripherin/rom-1_CS

1

IPR018499

18,499

Tetraspanin/Peripherin

Family

66,297

false

Tetraspanins are a distinct family of proteins, containing four transmembrane domains: a small outer loop (EC1), a larger outer loop (EC2), a small inner loop (IL) and short cytoplasmic tails. They contain characteristic structural features, including 4-6 conserved extracellular cysteine residues, and polar residues wi...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF00335", "PTHR19282" ]

[ "Tetraspanin", "" ]

[ 66280, 48678 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-114608", "R-BTA-1300645", "R-BTA-198933", "R-BTA-6798695", "R-BTA-977606", "R-CEL-6798695", "R-DME-6798695", "R-DRE-6798695", "R-HSA-114608", "R-HSA-1300645", "R-HSA-198933", "R-HSA-2022090", "R-HSA-202733", "R-HSA-416993", "R-HSA-446107", "R-HSA-5336415", "R-HSA-6798695", "...

[ "REACTOME:R-BTA-114608", "REACTOME:R-BTA-1300645", "REACTOME:R-BTA-198933", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-977606", "REACTOME:R-CEL-6798695", "REACTOME:R-DME-6798695", "REACTOME:R-DRE-6798695", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-1300645", "REACTOME:R-HSA-198933", "REACTOME:R-H...

33

[ "2m7z", "5tcx", "6k4j", "6wvg", "7jic", "7rd5", "7rdb", "7zw1", "8esv", "8jj5" ]

10

[ "PUB00004308" ]

[ "1610568" ]

[ "Cloning of the cDNA for a novel photoreceptor membrane protein (rom-1) identifies a disk rim protein family implicated in human retinopathies." ]

[ 1992 ]

1

[]

[ "IPR000301", "IPR000830", "IPR044991" ]

0

3

0

[ "Bacillati", "Eukaryota", "bird metagenome" ]

[ 6, 66287, 4 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 69, 25, 144, 63, 162, 108, 53, 137, 53 ]

9

true

Family

Tetraspanin/Peripherin

1

IPR018501

18,501

DDT domain

DDT_dom

Domain

21,229

false

The DDT has been named after the better characterised DNA-binding homeobox- containing proteins and the Different Transcription and chromatin remodelling factors in which it is found. It is a domain of about 60 amino acids which is exclusively associated with nuclear domains like AT-Hook, PHD finger, methyl-CpG-binding...

[]

0

[ "PFAM", "PROFILE", "SMART" ]

[ "PF02791", "PS50827", "SM00571" ]

[ "DDT", "DDT", "DDT" ]

[ 17764, 20127, 17291 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-427413", "R-HSA-5250924", "R-HSA-5693565", "R-MMU-5250924", "R-MMU-5693565" ]

[ "REACTOME:R-HSA-427413", "REACTOME:R-HSA-5250924", "REACTOME:R-HSA-5693565", "REACTOME:R-MMU-5250924", "REACTOME:R-MMU-5693565" ]

5

[]

0

[ "PUB00018298" ]

[ "11246006" ]

[ "DDT -- a novel domain in different transcription and chromosome remodeling factors." ]

[ 2001 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Ignisphaera aggregans", "bird metagenome" ]

[ 11, 21215, 2, 1 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 68, 9, 139, 18, 17, 17, 1, 22, 22, 2, 156 ]

11

true

Domain

DDT domain

DDT_dom

8

IPR018502

18,502

Annexin repeat

Annexin_repeat

Repeat

31,137

false

The annexins (or lipocortins) are a family of proteins that bind to phospholipids in a calcium-dependent manner [ ]. The 12 annexins common to vertebrates are classified in the annexin A family and named as annexins A1-A13 (or ANXA1-ANXA13), leaving A12 unassigned in the official nomenclature. Annexins outside vertebra...

[ "GO:0005509", "GO:0005544" ]

[ "calcium ion binding", "calcium-dependent phospholipid binding" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM", "PROFILE", "SMART" ]

[ "PF00191", "PS51897", "SM00335" ]

[ "Annexin", "ANNEXIN_2", "ANX" ]

[ 30911, 30500, 29949 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-6798695", "R-BTA-75205", "R-BTA-9860927", "R-CFA-6798695", "R-CFA-75205", "R-CFA-9860927", "R-DDI-114608", "R-DDI-6798695", "R-DME-114608", "R-DME-6798695", "R-DME-9860927", "R-GGA-114608", "R-GGA-6798695", "R-GGA-75205", "R-GGA-9860927", "R-HSA-114608", "R-HSA-416476", "R-H...

[ "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-75205", "REACTOME:R-BTA-9860927", "REACTOME:R-CFA-6798695", "REACTOME:R-CFA-75205", "REACTOME:R-CFA-9860927", "REACTOME:R-DDI-114608", "REACTOME:R-DDI-6798695", "REACTOME:R-DME-114608", "REACTOME:R-DME-6798695", "REACTOME:R-DME-9860927", "REACTOME:R-GG...

40

[ "1a8a", "1a8b", "1aei", "1aii", "1ain", "1ala", "1ann", "1anw", "1anx", "1aow", "1avc", "1avh", "1avr", "1axn", "1bc0", "1bc1", "1bc3", "1bcw", "1bcy", "1bcz", "1bo9", "1dk5", "1dm5", "1g5n", "1hak", "1hm6", "1hvd", "1hve", "1hvf", "1hvg", "1i4a", "1m9i"...

118

[ "PUB00001395", "PUB00013921", "PUB00015121" ]

[ "1646719", "9797403", "15059252" ]

[ "Amino acid sequence analysis of the annexin super-gene family of proteins.", "Identification of the first fungal annexin: analysis of annexin gene duplications and implications for eukaryotic evolution.", "The annexins." ]

[ 1991, 1998, 2004 ]

3

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 97, 31040 ]

2

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 35, 7, 47, 5, 124, 60, 2, 30, 73, 65 ]

10

true

Repeat

Annexin repeat

Annexin_repeat

5

IPR018503

18,503

Tetraspanin, conserved site

Tetraspanin_CS

Conserved_site

22,477

false

Tetraspanins are a distinct family of cell surface proteins, containing four conserved transmembrane domains: a small outer loop (EC1), a larger outer loop (EC2), a small inner loop (IL) and short cytoplasmic tails. They contain characteristic structural features, including 4-6 conserved extracellular cysteine residues...

[ "GO:0016020" ]

[ "membrane" ]

[ "cellular_component" ]

1

[ "PROSITE" ]

[ "PS00421" ]

[ "TM4_1" ]

[ 22477 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-114608", "R-BTA-1300645", "R-BTA-198933", "R-BTA-6798695", "R-BTA-977606", "R-DRE-6798695", "R-HSA-114608", "R-HSA-1300645", "R-HSA-198933", "R-HSA-2022090", "R-HSA-202733", "R-HSA-416993", "R-HSA-446107", "R-HSA-5336415", "R-HSA-6798695", "R-HSA-977225", "R-HSA-977606", "R-...

[ "REACTOME:R-BTA-114608", "REACTOME:R-BTA-1300645", "REACTOME:R-BTA-198933", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-977606", "REACTOME:R-DRE-6798695", "REACTOME:R-HSA-114608", "REACTOME:R-HSA-1300645", "REACTOME:R-HSA-198933", "REACTOME:R-HSA-2022090", "REACTOME:R-HSA-202733", "REACTOME:R-HS...

30

[ "5tcx", "6k4j", "7jic" ]

3

[ "PUB00010633" ]

[ "12575999" ]

[ "Functional domains in tetraspanin proteins." ]

[ 2003 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "bird metagenome" ]

[ 3, 22473, 1 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 5, 2, 63, 5, 102, 74, 7, 90, 6 ]

9

true

Conserved_site

Tetraspanin, conserved site

Tetraspanin_CS

9

IPR018504

18,504

RTX, pore-forming domain

RTX_pore_form

Domain

380

false

This is a hydrophobic pore-forming domain found towards the N-terminal of RTX toxins [ ]. Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior [ , ]. Four principal exotoxin secretion systems have been described. In the type II a...

[ "GO:0015267", "GO:0005576" ]

[ "channel activity", "extracellular region" ]

[ "molecular_function", "cellular_component" ]

2

[ "PFAM" ]

[ "PF02382" ]

[ "RTX" ]

[ 380 ]

1

[ "REACTOME" ]

[ "R-HSA-9760173" ]

[ "REACTOME:R-HSA-9760173" ]

1

[ "7usl" ]

1

[ "PUB00007655", "PUB00007656", "PUB00007657", "PUB00007658", "PUB00007659", "PUB00100829", "PUB00100830" ]

[ "1558765", "8800842", "10470043", "9521785", "8808931", "33260488", "30405113" ]

[ "Structural and functional relationships among the RTX toxin determinants of gram-negative bacteria.", "Biological effects of RTX toxins: the possible role of lipopolysaccharide.", "The interaction between RTX toxins and target cells.", "The biochemistry of hemolysin toxin activation: characterization of HlyC...

[ 1992, 1995, 1999, 1998, 1996, 2020, 2018 ]

7

[]

0

null

[ "Bacteria" ]

[ 380 ]

1

[]

0

true

Domain

RTX, pore-forming domain

RTX_pore_form

3

IPR018507

18,507

Cytochrome c oxidase, subunit VIa, conserved site

Cyt_c_oxidase_su6a_CS

Conserved_site

2,299

false

Cytochrome c oxidase ( ) is an oligomeric enzymatic complex which is a component of the respiratory chain complex and is involved in the transfer of electrons from cytochrome c to oxygen [ , ]. In eukaryotes this enzyme complex is located in the mitochondrial inner membrane; in aerobic prokaryotes it is found in the pl...

[ "GO:0005743" ]

[ "mitochondrial inner membrane" ]

[ "cellular_component" ]

1

[ "PROSITE" ]

[ "PS01329" ]

[ "COX6A" ]

[ 2299 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-5628897", "R-BTA-611105", "R-BTA-9707564", "R-BTA-9864848", "R-HSA-5628897", "R-HSA-611105", "R-HSA-9707564", "R-HSA-9864848", "R-MMU-5628897", "R-MMU-611105", "R-MMU-9707564", "R-MMU-9864848", "R-RNO-5628897", "R-RNO-611105", "R-RNO-9707564" ]

[ "REACTOME:R-BTA-5628897", "REACTOME:R-BTA-611105", "REACTOME:R-BTA-9707564", "REACTOME:R-BTA-9864848", "REACTOME:R-HSA-5628897", "REACTOME:R-HSA-611105", "REACTOME:R-HSA-9707564", "REACTOME:R-HSA-9864848", "REACTOME:R-MMU-5628897", "REACTOME:R-MMU-611105", "REACTOME:R-MMU-9707564", "REACTOME:R...

15

[ "1occ", "1oco", "1ocr", "1ocz", "1v54", "1v55", "2dyr", "2dys", "2eij", "2eik", "2eil", "2eim", "2ein", "2occ", "2y69", "2ybb", "2zxw", "3abk", "3abl", "3abm", "3ag1", "3ag2", "3ag3", "3ag4", "3asn", "3aso", "3wg7", "3x2q", "5b1a", "5b1b", "5b3s", "5gpn"...

122

[ "PUB00000581", "PUB00000674", "PUB00097156" ]

[ "6307356", "9107314", "28870773" ]

[ "Structure of cytochrome c oxidase.", "The cDNA sequences of cytochrome c oxidase subunit VIa from carp and rainbow trout suggest the absence of isoforms in fishes.", "Mitochondrial cytochrome c oxidase biogenesis: Recent developments." ]

[ 1983, 1997, 2018 ]

3

[]

0

null

[ "Eukaryota" ]

[ 2299 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 3, 6, 4, 6, 1, 1 ]

7

true

Conserved_site

Cytochrome c oxidase, subunit VIa, conserved site

Cyt_c_oxidase_su6a_CS

5

IPR018508

18,508

3-dehydroquinate dehydratase, active site

3-dehydroquinate_DH_AS

Active_site

3,377

false

3-dehydroquinate dehydratase ( ), or dehydroquinase, catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate. Two classes of dehydroquinases exist, known as types I and II. The best studied type I en...

[ "GO:0003855" ]

[ "3-dehydroquinate dehydratase activity" ]

[ "molecular_function" ]

1

[ "PROSITE" ]

[ "PS01028" ]

[ "DEHYDROQUINASE_I" ]

[ 3377 ]

1

[ "EC", "METACYC", "METACYC", "METACYC" ]

[ "4.2.1.10", "PWY-6163", "PWY-6416", "PWY-6707" ]

[ "EC:4.2.1.10", "METACYC:PWY-6163", "METACYC:PWY-6416", "METACYC:PWY-6707" ]

4

[ "1gqn", "1l9w", "1qfe", "2egz", "2ysw", "3js3", "3l2i", "3lb0", "3m7w", "3nnt", "3o1n", "3oex", "3s42", "4clm", "4cnn", "4cno", "4cnp", "4gfs", "4guf", "4gug", "4guh", "4gui", "4guj", "4h3d", "4iuo", "4ph6", "4uio", "5swu", "6h5c", "6h5d", "6h5g", "6h5j"...

37

[ "PUB00002745" ]

[ "1429576" ]

[ "Identification of the essential histidine residue at the active site of Escherichia coli dehydroquinase." ]

[ 1992 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "metagenomes" ]

[ 80, 2033, 1253, 11 ]

4

[ "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1, 1 ]

3

true

Active_site

3-dehydroquinate dehydratase, active site

3-dehydroquinate_DH_AS

3

IPR018509

18,509

Dehydroquinase, class II, conserved site

DHquinase_II_CS

Conserved_site

20,923

false

3-dehydroquinate dehydratase ( ), or dehydroquinase, catalyzes the conversion of 3-dehydroquinate into 3-dehydroshikimate. It is the third step in the shikimate pathway for the biosynthesis of aromatic amino acids from chorismate. Two classes of dehydroquinases exist, known as types I and II. Class-II enzymes are homod...

[ "GO:0003855" ]

[ "3-dehydroquinate dehydratase activity" ]

[ "molecular_function" ]

1

[ "PROSITE" ]

[ "PS01029" ]

[ "DEHYDROQUINASE_II" ]

[ 20923 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "REACTOME" ]

[ "4.2.1.10", "PWY-6163", "PWY-6416", "PWY-6707", "R-MTU-964903" ]

[ "EC:4.2.1.10", "METACYC:PWY-6163", "METACYC:PWY-6416", "METACYC:PWY-6707", "REACTOME:R-MTU-964903" ]

5

[ "1d0i", "1gqo", "1gu0", "1gu1", "1h05", "1h0r", "1h0s", "1j2y", "1uqr", "1v1j", "2bt4", "2c4v", "2c4w", "2c57", "2cjf", "2dhq", "2uyg", "2wks", "2xb8", "2xb9", "2xd9", "2xda", "2y71", "2y76", "2y77", "3kip", "3lwz", "3n59", "3n76", "3n7a", "3n86", "3n87"...

73

[ "PUB00003743", "PUB00003855" ]

[ "1910148", "8170389" ]

[ "The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases.", "Characterization of a 3-dehydroquinase gene from Actinobacillus pleuropneumoniae with homology to the eukaryotic genes qa-2 and QUTE." ]

[ 1991, 1994 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 19577, 1002, 344 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Conserved_site

Dehydroquinase, class II, conserved site

DHquinase_II_CS

2

IPR018510

18,510

Diaminopimelate epimerase, active site

DAP_epimerase_AS

Active_site

21,828

false

Bacteria, plants and fungi metabolise aspartic acid to produce four amino acids -lysine, threonine, methionine and isoleucine -in a series of reactions known as the aspartate pathway. Additionally, several important metabolic intermediates are produced by these reactions, such as diaminopimelic acid, an essential compo...

[ "GO:0008837", "GO:0009089", "GO:0005737" ]

[ "diaminopimelate epimerase activity", "L-lysine biosynthetic process via diaminopimelate", "cytoplasm" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PROSITE" ]

[ "PS01326" ]

[ "DAP_EPIMERASE" ]

[ 21828 ]

1

[ "EC", "METACYC", "METACYC" ]

[ "5.1.1.7", "PWY-2941", "PWY-5097" ]

[ "EC:5.1.1.7", "METACYC:PWY-2941", "METACYC:PWY-5097" ]

3

[ "1bwz", "1gqz", "2gke", "2gkj", "2otn", "2q9j", "3ejx", "3ekm", "3fve", "4ijz", "4ik0", "5h2g", "5h2y", "5ha4", "5m47", "5ygu", "6d13", "6d1q", "6d1v", "6vck", "6vcl", "6vcm", "8qzy", "9mro", "9mrp", "9mrv" ]

26

[ "PUB00000449", "PUB00025347", "PUB00034672", "PUB00034679", "PUB00034680" ]

[ "9843410", "14747737", "11352712", "10508663", "15652176" ]

[ "Structural symmetry: the three-dimensional structure of Haemophilus influenzae diaminopimelate epimerase.", "Refinement of Haemophilus influenzae diaminopimelic acid epimerase (DapF) at 1.75 A resolution suggests a mechanism for stereocontrol during catalysis.", "The central enzymes of the aspartate family of ...

[ 1998, 2004, 2001, 1999, 2005 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences" ]

[ 132, 20413, 892, 391 ]

4

[ "Arabidopsis thaliana", "Escherichia coli (strain K12)", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 5, 1, 2, 17 ]

4

true

Active_site

Diaminopimelate epimerase, active site

DAP_epimerase_AS

9

IPR018511

18,511

Hemolysin-type calcium-binding conserved site

Hemolysin-typ_Ca-bd_CS

Conserved_site

37,615

false

Gram-negative bacteria produce a number of proteins that are secreted into the growth medium by a mechanism by the type I secretion system that does not require a cleaved N-terminal signal sequence. These proteins, while having different functions, share two properties: they bind calcium and they contain a multiple tan...

[]

0

[ "PROSITE" ]

[ "PS00330" ]

[ "HEMOLYSIN_CALCIUM" ]

[ 37615 ]

1

[ "REACTOME" ]

[ "R-HSA-9760173" ]

[ "REACTOME:R-HSA-9760173" ]

1

[ "1af0", "1akl", "1g9k", "1go7", "1go8", "1h71", "1jiw", "1k7g", "1k7i", "1k7q", "1kap", "1o0q", "1o0t", "1om6", "1om7", "1om8", "1omj", "1sat", "1smp", "1srp", "2agm", "2ml1", "2ml2", "2ml3", "2z8x", "2z8z", "2zj6", "2zj7", "2zvd", "3a6z", "3a70", "3hb2"...

51

[ "PUB00001195", "PUB00001236" ]

[ "2303029", "8253063" ]

[ "The Rhizobium nodulation gene nodO encodes a Ca2(+)-binding protein that is exported without N-terminal cleavage and is homologous to haemolysin and related proteins.", "Three-dimensional structure of the alkaline protease of Pseudomonas aeruginosa: a two-domain protein with a calcium binding parallel beta roll ...

[ 1990, 1993 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 53, 37000, 322, 239, 1 ]

5

[]

0

true

Conserved_site

Hemolysin-type calcium-binding conserved site

Hemolysin-typ_Ca-bd_CS

3

IPR018514

18,514

Rabaptin coiled-coil domain

Rabaptin_CC

Domain

2,749

false

Regeneration of injured axons at neuromuscular junctions has been assumed to be regulated by extra-cellular factors that promote neurite outgrowth. A novel neurite outgrowth factor from chick denervated skeletal muscle has been cloned and characterised. The protein, termed neurocrescin (rabaptin), has been shown to be ...

[ "GO:0005096", "GO:0008083" ]

[ "GTPase activator activity", "growth factor activity" ]

[ "molecular_function", "molecular_function" ]

2

[ "PFAM" ]

[ "PF03528" ]

[ "Rabaptin" ]

[ 2749 ]

1

[ "REACTOME" ]

[ "R-HSA-8854214" ]

[ "REACTOME:R-HSA-8854214" ]

1

[]

0

[ "PUB00007620", "PUB00007621" ]

[ "9427343", "8521472" ]

[ "Neurocrescin: a novel neurite-outgrowth factor secreted by muscle after denervation.", "Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion." ]

[ 1997, 1995 ]

2

[]

0

null

[ "Opisthokonta" ]

[ 2749 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 15, 7, 18 ]

4

true

Domain

Rabaptin coiled-coil domain

Rabaptin_CC

8

IPR018515

18,515

Tuberin-type domain

Tuberin-type_domain

Domain

4,646

false

Initiation of eukaryotic mRNA transcription requires melting of promoter DNA with the help of the general transcription factors TFIIE and TFIIH. In higher eukaryotes, the general transcription factor TFIIE consists of two subunits: the large alpha subunit ( ) and the small beta ( ). TFIIE beta has been found to bind to...

[ "GO:0005096", "GO:0043547" ]

[ "GTPase activator activity", "positive regulation of GTPase activity" ]

[ "molecular_function", "biological_process" ]

2

[ "PFAM" ]

[ "PF03542" ]

[ "Tuberin" ]

[ 4646 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-HSA-1632852", "R-HSA-165181", "R-HSA-198323", "R-HSA-380972", "R-HSA-5628897", "R-HSA-5674400", "R-HSA-8854214", "R-MMU-1632852", "R-MMU-165181", "R-MMU-198323", "R-MMU-380972", "R-MMU-5628897", "R-MMU-8854214", "R-RNO-1632852", "R-RNO-165181", "R-RNO-198323", "R-RNO-380972", "R...

[ "REACTOME:R-HSA-1632852", "REACTOME:R-HSA-165181", "REACTOME:R-HSA-198323", "REACTOME:R-HSA-380972", "REACTOME:R-HSA-5628897", "REACTOME:R-HSA-5674400", "REACTOME:R-HSA-8854214", "REACTOME:R-MMU-1632852", "REACTOME:R-MMU-165181", "REACTOME:R-MMU-198323", "REACTOME:R-MMU-380972", "REACTOME:R-MM...

23

[ "7dl2", "9ce3" ]

2

[ "PUB00006521" ]

[ "10716934" ]

[ "Structure of the central core domain of TFIIEbeta with a novel double-stranded DNA-binding surface." ]

[ 2000 ]

1

[]

0

null

[ "Eukaryota" ]

[ 4646 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 5, 8, 28, 12, 2, 7, 2 ]

7

true

Domain

Tuberin-type domain

Tuberin-type_domain

1

IPR018517

18,517

tRNA-dihydrouridine synthase, conserved site

tRNA_hU_synthase_CS

Conserved_site

57,054

false

Members of this family catalyse the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also in some archaea. Most dihydrouridines are found in the D loop of tRNAs. The role of dihydrouridine in tRNA is currently unknow...

[ "GO:0017150", "GO:0050660", "GO:0008033" ]

[ "tRNA dihydrouridine synthase activity", "flavin adenine dinucleotide binding", "tRNA processing" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PROSITE" ]

[ "PS01136" ]

[ "UPF0034" ]

[ 57054 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "1.3.1", "1.3.1.-", "PWY-2541", "PWY-5292", "PWY-5301", "PWY-5367", "PWY-5393", "PWY-5729", "PWY-5818", "PWY-5956", "PWY-5972", "PWY-5984", "PWY-6088", "PWY-6302", "PWY-6309", "PWY-6332", "PWY-6786", "PWY-6824", "PWY-6944", "PWY-6996", "PWY-7096", "PWY-7154", "PWY-7155", ...

[ "EC:1.3.1", "EC:1.3.1.-", "METACYC:PWY-2541", "METACYC:PWY-5292", "METACYC:PWY-5301", "METACYC:PWY-5367", "METACYC:PWY-5393", "METACYC:PWY-5729", "METACYC:PWY-5818", "METACYC:PWY-5956", "METACYC:PWY-5972", "METACYC:PWY-5984", "METACYC:PWY-6088", "METACYC:PWY-6302", "METACYC:PWY-6309", ...

39

[ "1vhn", "3b0p", "3b0u", "3b0v", "3w9z", "4bf9", "4bfa", "4wfs", "4xp7", "6ei9", "6eza", "6ezb", "6ezc" ]

13

[ "PUB00014304" ]

[ "12003496" ]

[ "A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA." ]

[ 2002 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Myoviridae sp. ct8aR17", "unclassified sequences" ]

[ 87, 39841, 16560, 1, 565 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 24, 4, 5, 6, 3, 16, 10, 4, 12, 18, 4, 4, 24 ]

13

true

Conserved_site

tRNA-dihydrouridine synthase, conserved site

tRNA_hU_synthase_CS

8

IPR018520

18,520

Di-trans-poly-cis-decaprenylcistransferase-like, conserved site

UPP_synth-like_CS

Conserved_site

36,138

false

Synonym(s): Di-trans-poly-cis-undecaprenyl-diphosphate synthase, Undecaprenyl pyrophosphate synthetase, Undecaprenyl pyrophosphate synthase, UPP synthetase Di-trans-poly-cis-decaprenylcistransferase ( ) (UPP synthetase) generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP) [ ]. This bacterial ...

[ "GO:0016765" ]

[ "transferase activity, transferring alkyl or aryl (other than methyl) groups" ]

[ "molecular_function" ]

1

[ "PROSITE" ]

[ "PS01066" ]

[ "UPP_SYNTHASE" ]

[ 36138 ]

1

[ "EC", "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "...

[ "2.5.1", "2.5.1.-", "PWY-4502", "PWY-4681", "PWY-5802", "PWY-5815", "PWY-5816", "PWY-5817", "PWY-5893", "PWY-5979", "PWY-6262", "PWY-6403", "PWY-6659", "PWY-6681", "PWY-6936", "PWY-7372", "PWY-7405", "PWY-7407", "PWY-7493", "PWY-7520", "PWY-7529", "PWY-7532", "PWY-7540", ...

[ "EC:2.5.1", "EC:2.5.1.-", "METACYC:PWY-4502", "METACYC:PWY-4681", "METACYC:PWY-5802", "METACYC:PWY-5815", "METACYC:PWY-5816", "METACYC:PWY-5817", "METACYC:PWY-5893", "METACYC:PWY-5979", "METACYC:PWY-6262", "METACYC:PWY-6403", "METACYC:PWY-6659", "METACYC:PWY-6681", "METACYC:PWY-6936", ...

49

[ "1f75", "1jp3", "1ueh", "1v7u", "1x06", "1x07", "1x08", "1x09", "2d2r", "2dtn", "2e98", "2e99", "2e9a", "2e9c", "2e9d", "2vfw", "2vg0", "2vg1", "2vg2", "2vg3", "2vg4", "3qas", "3sgt", "3sgv", "3sgx", "3sh0", "3th8", "3ugs", "3wyi", "3wyj", "4h2j", "4h2m"...

81

[ "PUB00002321" ]

[ "9882662" ]

[ "Use of genomics to identify bacterial undecaprenyl pyrophosphate synthetase: cloning, expression, and characterization of the essential uppS gene." ]

[ 1999 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 867, 28298, 6285, 3, 685 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 38, 1, 1, 1, 1, 8, 5, 1, 7, 4, 2, 1, 22 ]

13

true

Conserved_site

Di-trans-poly-cis-decaprenylcistransferase-like, conserved site

UPP_synth-like_CS

4

IPR018521

18,521

DNA topoisomerase IB, active site

TopoIB_AS

Active_site

7,471

false

This entry represents the region around the active site tyrosine in eukaryotes and poxvirus topoisomerases IB (Topo IB). DNA topoisomerase I ( ) [ , , , ] is one of the two types of enzyme that catalyze the interconversion of topological DNA isomers. Type I topoisomerases act by catalyzing the transient breakage of DNA...

[ "GO:0003677", "GO:0003917", "GO:0006265" ]

[ "DNA binding", "DNA topoisomerase type I (single strand cut, ATP-independent) activity", "DNA topological change" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PROSITE" ]

[ "PS00176" ]

[ "TOPO_IB_1" ]

[ 7471 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.6.2.1", "R-CEL-4615885", "R-DDI-4615885", "R-HSA-4615885", "R-MMU-4615885", "R-RNO-4615885", "R-SCE-4615885", "R-SPO-4615885" ]

[ "EC:5.6.2.1", "REACTOME:R-CEL-4615885", "REACTOME:R-DDI-4615885", "REACTOME:R-HSA-4615885", "REACTOME:R-MMU-4615885", "REACTOME:R-RNO-4615885", "REACTOME:R-SCE-4615885", "REACTOME:R-SPO-4615885" ]

8

[ "1a31", "1a41", "1k4s", "1k4t", "1nh3", "1rr8", "1rrj", "1sc7", "1seu", "1t8i", "1tl8", "2b9s", "2h7f", "2h7g", "3igc" ]

15

[ "PUB00001050", "PUB00001088", "PUB00004680", "PUB00005230", "PUB00005437", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00081702", "PUB00081703", "PUB00081704", "PUB00081705" ]

[ "2560656", "7773745", "2542938", "9488644", "7770916", "11395412", "12596227", "12042765", "21087076", "20644584", "17722649", "17293019" ]

[ "DNA topoisomerases.", "DNA topoisomerases.", "Peptide sequencing and site-directed mutagenesis identify tyrosine-727 as the active site tyrosine of Saccharomyces cerevisiae DNA topoisomerase I.", "Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA.", "The mechanisms ...

[ 1989, 1995, 1989, 1998, 1995, 2001, 2003, 2002, 2010, 2010, 2007, 2007 ]

12

[]

0

null

[ "Eukaryota", "Nucleocytoviricota", "viral metagenome" ]

[ 7370, 97, 4 ]

3

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)", "Zea ma...

[ 18, 1, 7, 6, 13, 3, 2, 3, 1, 1, 14 ]

11

true

Active_site

DNA topoisomerase IB, active site

TopoIB_AS

3

IPR018522

18,522

DNA topoisomerase, type IIA, conserved site

TopoIIA_CS

Conserved_site

65,712

false

DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single-or double-strand breaks, crossing the strands through one another, then resealing the breaks [ ]. These enzymes have several functions: to remove DNA supercoi...

[ "GO:0003677", "GO:0003918", "GO:0005524", "GO:0006265" ]

[ "DNA binding", "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity", "ATP binding", "DNA topological change" ]

[ "molecular_function", "molecular_function", "molecular_function", "biological_process" ]

4

[ "PROSITE" ]

[ "PS00177" ]

[ "TOPOISOMERASE_II" ]

[ 65712 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "5.6.2.2", "R-CEL-4615885", "R-DDI-4615885", "R-DME-4615885", "R-HSA-1362277", "R-HSA-4615885", "R-HSA-9638771", "R-HSA-9913143", "R-MMU-4615885", "R-RNO-4615885", "R-SCE-4615885", "R-SPO-4615885", "R-SSC-4615885" ]

[ "EC:5.6.2.2", "REACTOME:R-CEL-4615885", "REACTOME:R-DDI-4615885", "REACTOME:R-DME-4615885", "REACTOME:R-HSA-1362277", "REACTOME:R-HSA-4615885", "REACTOME:R-HSA-9638771", "REACTOME:R-HSA-9913143", "REACTOME:R-MMU-4615885", "REACTOME:R-RNO-4615885", "REACTOME:R-SCE-4615885", "REACTOME:R-SPO-4615...

13

[ "1bgw", "1bjt", "2rgr", "2xco", "2xcq", "2xcr", "2xcs", "2xct", "2xkj", "2xkk", "2zjt", "3foe", "3fof", "3ig0", "3k9f", "3ksa", "3ksb", "3l4j", "3l4k", "3ltn", "3m4i", "3nuh", "3qx3", "3rad", "3rae", "3raf", "4bul", "4fm9", "4g0u", "4g0v", "4g0w", "4gfh"...

159

[ "PUB00001050", "PUB00001088", "PUB00005437", "PUB00016842", "PUB00020793", "PUB00020794", "PUB00020795" ]

[ "2560656", "7773745", "7770916", "11395412", "12596227", "12042765", "7980433" ]

[ "DNA topoisomerases.", "DNA topoisomerases.", "The mechanisms of DNA topoisomerases.", "DNA topoisomerases: structure, function, and mechanism.", "Phylogenomics of type II DNA topoisomerases.", "Cellular roles of DNA topoisomerases: a molecular perspective.", "Structure and function of type II DNA topoi...

[ 1989, 1995, 1995, 2001, 2003, 2002, 1994 ]

7

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "unclassified sequences" ]

[ 528, 55423, 8338, 479, 944 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Escherichia coli (strain K12)", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus",...

[ 14, 4, 5, 1, 2, 8, 4, 2, 7, 7, 1, 1, 56 ]

13

true

Conserved_site

DNA topoisomerase, type IIA, conserved site

TopoIIA_CS

8

IPR018523

18,523

Isocitrate lyase/phosphorylmutase, conserved site

Isocitrate_lyase_ph_CS

Conserved_site

25,459

false

Isocitrate lyase ( ) [ , ] is an enzyme that catalyzes the conversion of isocitrate to succinate and glyoxylate. This is the first step in the glyoxylate bypass, an alternative to the tricarboxylic acid cycle in bacteria, fungi and plants. A cysteine, a histidine and a glutamate or aspartate have been found to be impor...

[ "GO:0003824" ]

[ "catalytic activity" ]

[ "molecular_function" ]

1

[ "PROSITE" ]

[ "PS00161" ]

[ "ISOCITRATE_LYASE" ]

[ 25459 ]

1

[ "EC", "EC" ]

[ "4.1.3", "4.1.3.1" ]

[ "EC:4.1.3", "EC:4.1.3.1" ]

2

[ "1dqu", "1f61", "1f8m", "1igw", "1mum", "1o5q", "1oqf", "1ujq", "1zlp", "3e5b", "3eol", "3eoo", "3fa3", "3fa4", "3i4e", "3lg3", "3lye", "3m0j", "3m0k", "3oq8", "3p0x", "4iqd", "4iqe", "5dql", "5e9f", "5e9g", "5e9h", "6edw", "6edz", "6ee1", "6lrp", "6lrt"...

52

[ "PUB00002339", "PUB00005064" ]

[ "2361956", "2696959" ]

[ "Peroxisomal isocitrate lyase of the n-alkane-assimilating yeast Candida tropicalis: gene analysis and characterization.", "High sequence conservation between isocitrate lyase from Escherichia coli and Ricinus communis." ]

[ 1990, 1989 ]

2

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 215, 18424, 6581, 237, 2 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Escherichia coli (strain K12)", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Zea mays" ]

[ 10, 1, 2, 3, 7, 2, 7 ]

7

true

Conserved_site

Isocitrate lyase/phosphorylmutase, conserved site

Isocitrate_lyase_ph_CS

5

IPR018524

18,524

DNA/RNA non-specific endonuclease, active site

DNA/RNA_endonuclease_AS

Active_site

7,998

false

A family of bacterial and eukaryotic endonucleases share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. A histidine has been shown [ ] to be essential for the activity of the Serratia ...

[ "GO:0003676", "GO:0016787", "GO:0046872" ]

[ "nucleic acid binding", "hydrolase activity", "metal ion binding" ]

[ "molecular_function", "molecular_function", "molecular_function" ]

3

[ "PROSITE" ]

[ "PS01070" ]

[ "NUCLEASE_NON_SPEC" ]

[ 7998 ]

1

[ "EC" ]

[ "3.1.30.-" ]

[ "EC:3.1.30.-" ]

1

[ "1g8t", "1qae", "1ql0", "1smn", "3ism", "3s5b", "4e3y", "4qn0" ]

8

[ "PUB00004455" ]

[ "8078761" ]

[ "Identification of catalytically relevant amino acids of the extracellular Serratia marcescens endonuclease by alignment-guided mutagenesis." ]

[ 1994 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Halobacteriales", "Viruses", "metagenomes" ]

[ 4352, 3593, 3, 9, 41 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizo...

[ 5, 1, 2, 4, 2, 2, 1, 2, 1, 1, 7 ]

11

true

Active_site

DNA/RNA non-specific endonuclease, active site

DNA/RNA_endonuclease_AS

2

IPR018525

18,525

Mini-chromosome maintenance, conserved site

MCM_CS

Conserved_site

28,959

false

MCM proteins are DNA-dependent ATPases required for the initiation of eukaryotic DNA replication [ , , ]. In eukaryotes there is a family of six proteins, MCM2 to MCM7. They were first identified in yeast where most of them have a direct role in the initiation of chromosomal DNA replication by interacting directly with...

[ "GO:0003677", "GO:0005524", "GO:0006260" ]

[ "DNA binding", "ATP binding", "DNA replication" ]

[ "molecular_function", "molecular_function", "biological_process" ]

3

[ "PROSITE" ]

[ "PS00847" ]

[ "MCM_1" ]

[ 28959 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.6.4.12", "R-BTA-176187", "R-BTA-68867", "R-BTA-68949", "R-BTA-68962", "R-BTA-69052", "R-CEL-68867", "R-CEL-68949", "R-CEL-68962", "R-CEL-69052", "R-DDI-68867", "R-DDI-68962", "R-DDI-69052", "R-DME-176187", "R-DME-68867", "R-DME-68949", "R-DME-68962", "R-DME-69052", "R-HSA-1761...

[ "EC:3.6.4.12", "REACTOME:R-BTA-176187", "REACTOME:R-BTA-68867", "REACTOME:R-BTA-68949", "REACTOME:R-BTA-68962", "REACTOME:R-BTA-69052", "REACTOME:R-CEL-68867", "REACTOME:R-CEL-68949", "REACTOME:R-CEL-68962", "REACTOME:R-CEL-69052", "REACTOME:R-DDI-68867", "REACTOME:R-DDI-68962", "REACTOME:R-...

43

[ "3ja8", "3jc5", "3jc6", "3jc7", "5bk4", "5u8s", "5u8t", "5v8f", "5xf8", "6eyc", "6f0l", "6hv9", "6ptj", "6ptn", "6pto", "6raw", "6rax", "6ray", "6raz", "6rqc", "6skl", "6sko", "6u0m", "6wgc", "6wgf", "6wgg", "6wgi", "6xtx", "6xty", "7p30", "7p5z", "7pfo"...

84

[ "PUB00004410", "PUB00004422", "PUB00004436", "PUB00005507", "PUB00006384", "PUB00006390", "PUB00006394", "PUB00006498", "PUB00006510" ]

[ "1454522", "8332451", "8265339", "14731643", "9305914", "9366552", "9383050", "9658174", "10588642" ]

[ "Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication.", "A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication.", "The P1 family: a new cla...

[ 1992, 1993, 1993, 1994, 1997, 1997, 1997, 1998, 1999 ]

9

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "ecological metagenomes", "unclassified Caudoviricetes" ]

[ 473, 30, 28442, 12, 2 ]

5

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 29, 6, 13, 9, 46, 25, 6, 10, 23, 6, 6, 96 ]

12

true

Conserved_site

Mini-chromosome maintenance, conserved site

MCM_CS

5

IPR018526

18,526

Glycoside hydrolase, family 29, conserved site

Glyco_hydro_29_CS

Conserved_site

2,592

false

O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ ,...

[ "GO:0004560", "GO:0005975" ]

[ "alpha-L-fucosidase activity", "carbohydrate metabolic process" ]

[ "molecular_function", "biological_process" ]

2

[ "PROSITE" ]

[ "PS00385" ]

[ "ALPHA_L_FUCOSIDASE" ]

[ 2592 ]

1

[ "EC", "METACYC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "3.2.1.51", "PWY-6807", "R-BTA-6798695", "R-BTA-975578", "R-CEL-381426", "R-CEL-6798695", "R-CEL-8957275", "R-CEL-975578", "R-DDI-6798695", "R-DDI-975578", "R-HSA-381426", "R-HSA-6798695", "R-HSA-8957275", "R-HSA-975578", "R-MMU-381426", "R-MMU-6798695", "R-MMU-8957275", "R-MMU-975...

[ "EC:3.2.1.51", "METACYC:PWY-6807", "REACTOME:R-BTA-6798695", "REACTOME:R-BTA-975578", "REACTOME:R-CEL-381426", "REACTOME:R-CEL-6798695", "REACTOME:R-CEL-8957275", "REACTOME:R-CEL-975578", "REACTOME:R-DDI-6798695", "REACTOME:R-DDI-975578", "REACTOME:R-HSA-381426", "REACTOME:R-HSA-6798695", "R...

22

[ "7pls", "7pm4" ]

2

[ "PUB00000482", "PUB00004870", "PUB00005266", "PUB00021761", "PUB00043486", "PUB00043487" ]

[ "2482732", "7624375", "8535779", "14715651", "18556148", "18522672" ]

[ "Isolation and sequence analysis of a cDNA encoding rat liver alpha-L-fucosidase.", "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases.", "Structures and mechanisms of glycosyl hydrolases.", "Crystal structure of Thermotoga maritima alpha-L-fucosidas...

[ 1989, 1995, 1995, 2004, 2008, 2008 ]

6

[]

0

null

[ "Eukaryota" ]

[ 2592 ]

1

[ "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 1, 4, 3, 4, 7 ]

5

true

Conserved_site

Glycoside hydrolase, family 29, conserved site

Glyco_hydro_29_CS

5

IPR018527

18,527

Rubredoxin, iron-binding site

Rubredoxin_Fe_BS

Binding_site

14,724

false

Rubredoxin is a low molecular weight iron-containing protein involved in electron transfer [ , ], sometimes replacing ferredoxin as an electron carrier [ ]. It is found in bacteria, archaea and plants. The 3-D structures of a number of rubredoxins have been solved [ , ]. The fold belongs to the α+β class, with 2 α-heli...

[ "GO:0046872" ]

[ "metal ion binding" ]

[ "molecular_function" ]

1

[ "PROSITE" ]

[ "PS00202" ]

[ "RUBREDOXIN" ]

[ 14724 ]

1

[]

0

[ "1b13", "1b2j", "1b2o", "1bfy", "1bq8", "1bq9", "1brf", "1c09", "1caa", "1cad", "1e8j", "1fhh", "1fhm", "1irn", "1iro", "1iu5", "1iu6", "1r0f", "1r0g", "1r0h", "1r0i", "1r0j", "1rb9", "1rdg", "1rdv", "1rwd", "1s24", "1smm", "1smu", "1smw", "1spw", "1t9o"...

104

[ "PUB00000489", "PUB00003266", "PUB00008022", "PUB00008023", "PUB00008024" ]

[ "2244884", "1992166", "7726577", "1303768", "3441010" ]

[ "Rubredoxin from Clostridium thermosaccharolyticum. Amino acid sequence, mass-spectrometric and preliminary crystallographic data.", "Structure of rubredoxin from Desulfovibrio vulgaris at 1.5 A resolution.", "Isolation, characterization, and primary structure of rubredoxin from the photosynthetic bacterium, He...

[ 1990, 1991, 1995, 1992, 1987 ]

5

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 365, 12782, 1215, 19, 343 ]

5

[ "Arabidopsis thaliana", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 2, 3, 15 ]

3

true

Binding_site

Rubredoxin, iron-binding site

Rubredoxin_Fe_BS

9

IPR018530

18,530

PA14_02130

Domain

1,581

false

This entry represents a domain in Uncharacterized protein PA14_02130 which is part of the SiaC family regulatory phosphoprotein. They undergo a regulatory phosphorylation at Thr-68. Also, it is part of motif NTSS, so may contain more than one phosphorylation site. Phosphorylation causes regulatory change to protein-pro...

[]

0

[ "PFAM" ]

[ "PF09345" ]

[ "SiaC" ]

[ 1581 ]

1

[]

0

[ "6k4f", "6kko", "6kkp", "7e6g" ]

4

[ "PUB00098623", "PUB00105677" ]

[ "33156827", "32090355" ]

[ "The SiaABC threonine phosphorylation pathway controls biofilm formation in response to carbon availability in Pseudomonas aeruginosa.", "The SiaA/B/C/D signaling network regulates biofilm formation in Pseudomonas aeruginosa." ]

[ 2020, 2020 ]

2

[]

0

null

[ "Bacteria", "Eukaryota", "Methanospirillum stamsii", "metagenomes" ]

[ 1555, 3, 1, 22 ]

4

[]

0

true

Domain

PA14_02130

1

IPR018531

18,531

Protein of unknown function DUF1993

DUF1993

Family

6,468

false

This family of proteins are functionally uncharacterised.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09351", "PTHR36922" ]

[ "DUF1993", "" ]

[ 6468, 6396 ]

2

[]

0

[ "2oqm", "3qth" ]

2

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "metagenomes" ]

[ 4603, 1840, 25 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 2 ]

1

true

Family

Protein of unknown function DUF1993

DUF1993

9

IPR018533

18,533

Forkhead box protein, C-terminal

Forkhead_box_C

Domain

1,674

false

This presumed domain is found in the C-terminal region of Hepatocyte Nuclear Factor 3 alpha and beta chains. Its specific function is uncertain. The N-terminal region of this presumed domain contains an EH1 (engrailed homology 1) motif, that is characterised by the FxIxxIL sequence [ ].

[]

0

[ "PFAM" ]

[ "PF09354" ]

[ "HNF_C" ]

[ 1674 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-210745", "R-HSA-9018519", "R-HSA-9764790", "R-HSA-9796292", "R-HSA-9823730", "R-HSA-9925561", "R-HSA-9925563", "R-HSA-9937080", "R-MMU-9018519", "R-RNO-9018519" ]

[ "REACTOME:R-HSA-210745", "REACTOME:R-HSA-9018519", "REACTOME:R-HSA-9764790", "REACTOME:R-HSA-9796292", "REACTOME:R-HSA-9823730", "REACTOME:R-HSA-9925561", "REACTOME:R-HSA-9925563", "REACTOME:R-HSA-9937080", "REACTOME:R-MMU-9018519", "REACTOME:R-RNO-9018519" ]

10

[ "8vfy", "8vfz", "8vg1", "8vg2" ]

4

[ "PUB00044303" ]

[ "16309560" ]

[ "The EH1 motif in metazoan transcription factors." ]

[ 2005 ]

1

[]

0

null

[ "Eumetazoa" ]

[ 1674 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 3, 5, 5, 12 ]

4

true

Domain

Forkhead box protein, C-terminal

Forkhead_box_C

5

IPR018534

18,534

Tetracycline regulation of excision, RteC

Tet_reg_excision_RteC

Family

3,689

false

Human colonic Bacteroides species harbour a family of large conjugative transposons, called tetracycline resistance (Tcr) elements. Activities of these elements are enhanced by pregrowth of bacteria in medium containing tetracycline, indicating that at least some Tcr element genes are regulated by tetracycline. An inse...

[]

0

[ "PFAM" ]

[ "PF09357" ]

[ "RteC" ]

[ 3689 ]

1

[]

0

[]

0

[ "PUB00044478" ]

[ "8407786" ]

[ "Tetracycline regulation of genes on Bacteroides conjugative transposons." ]

[ 1993 ]

1

[]

0

null

[ "Bacteria", "Geoglossaceae", "metagenomes" ]

[ 3631, 2, 56 ]

3

[]

0

true

Family

Tetracycline regulation of excision, RteC

Tet_reg_excision_RteC

9

IPR018535

18,535

Domain of unknown function DUF1996

DUF1996

Domain

12,818

false

This family of proteins are functionally uncharacterised.

[]

0

[ "PFAM" ]

[ "PF09362" ]

[ "DUF1996" ]

[ 12818 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota", "freshwater metagenome" ]

[ 4217, 8579, 22 ]

3

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 9 ]

1

true

Domain

Domain of unknown function DUF1996

DUF1996

4

IPR018536

18,536

Chromophore lyase CpcS/CpeS

CpcS/CpeS

Family

1,303

false

This entry represents the CpcS/CpeS biliprotein lyase family, which have been shown to covalently attach chromophores to cystiene residue(s) of phycobiliproteins [ , ]. In the chromatically adapting cyanobacterium Fremyella diplosiphon, the proteins have been shown to be induced by green light, as part of the cpeCDESTR...

[ "GO:0017009" ]

[ "protein-phycocyanobilin linkage" ]

[ "biological_process" ]

1

[ "HAMAP", "PFAM" ]

[ "MF_01459", "PF09367" ]

[ "Chrphore_lyase_CpxS", "CpeS" ]

[ 1248, 1299 ]

2

[]

0

[ "3bdr", "4tq2" ]

2

[ "PUB00053876", "PUB00056794", "PUB00056795" ]

[ "12067341", "17895251", "17726096" ]

[ "CpeR is an activator required for expression of the phycoerythrin operon (cpeBA) in the cyanobacterium Fremyella diplosiphon and is encoded in the phycoerythrin linker-polypeptide operon (cpeCDESTR).", "Lyase activities of CpcS- and CpcT-like proteins from Nostoc PCC7120 and sequential reconstitution of binding ...

[ 2002, 2007, 2007 ]

3

[]

0

null

[ "Cyanobacteriota", "Eukaryota" ]

[ 1211, 92 ]

2

[]

0

true

Family

Chromophore lyase CpcS/CpeS

CpcS/CpeS

9

IPR018537

18,537

Peptidoglycan binding domain

Peptidoglycan-bd_3

Domain

4,460

false

This entry represents a peptidoglycan binding domain [ ] frequently found at the C terminus of proteins containing a N-terminal domain, predominantly in bacteria and virus, including Glycoside hydrolase family 108 protein from Salmonella typhi (TtsA, ). TtsA is a specific muramidase that facilitates toxin transport thr...

[]

0

[ "PFAM" ]

[ "PF09374" ]

[ "PG_binding_3" ]

[ 4460 ]

1

[]

0

[ "2ikb", "2is5", "2nr7", "6v3z", "6v40", "7dnp" ]

6

[ "PUB00021044", "PUB00101029", "PUB00101030" ]

[ "16155206", "23174673", "31958059" ]

[ "COG3926 and COG5526: a tale of two new lysozyme-like protein families.", "A Salmonella Typhi homologue of bacteriophage muramidases controls typhoid toxin secretion.", "Mechanisms of substrate recognition by a typhoid toxin secretion-associated muramidase." ]

[ 2005, 2013, 2020 ]

3

[]

0

null

[ "Bacteria", "Eukaryota", "Viruses", "metagenomes" ]

[ 4085, 14, 291, 70 ]

4

[]

0

true

Domain

Peptidoglycan binding domain

Peptidoglycan-bd_3

2

IPR018538

18,538

Helicase HerA, barrel domain

HerA_barrel_dom

Domain

1,031

false

The HAS barrel is named after HerA, which is a DNA helicase able to utilise either 3' or 5' single-stranded DNA extensions for loading and subsequent DNA duplex unwinding [ ]. It forms a complex with NurA nuclease, this complex has the 5'-3' DNA end resection activity and is essential for cell viability in the crenarch...

[]

0

[ "PFAM" ]

[ "PF09378" ]

[ "HAS-barrel" ]

[ 1031 ]

1

[ "EC", "EC" ]

[ "5.6.2.3", "5.6.2.4" ]

[ "EC:5.6.2.3", "EC:5.6.2.4" ]

2

[ "4d2i" ]

1

[ "PUB00044297", "PUB00076694", "PUB00076695" ]

[ "15466593", "14990749", "25880130" ]

[ "Comparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packaging.", "A bipolar DNA helicase gene, herA, clusters with rad50, mre11 and nurA genes in thermophilic archaea.", "Efficient 5'-3' DNA end resection b...

[ 2004, 2004, 2015 ]

3

[]

0

null

[ "Archaea", "Bacteria", "unclassified sequences" ]

[ 289, 714, 28 ]

3

[]

0

true

Domain

Helicase HerA, barrel domain

HerA_barrel_dom

1

IPR018540

18,540

Aspartyl-phosphate phosphatase Spo0E-like

Spo0E-like

Family

7,303

false

Spo0E is an aspartyl-phosphate phosphatase which specifically dephosphorylates the sporulation transcription factor Spo0A-P and negatively regulates the sporulation initiation pathway in order to control the proper timing of sporulation [ ]. The structure of Spo0E has revealed an anti-parallel α-helical structure [ ]. ...

[ "GO:0043937" ]

[ "regulation of sporulation" ]

[ "biological_process" ]

1

[ "PFAM" ]

[ "PF09388" ]

[ "SpoOE-like" ]

[ 7303 ]

1

[ "EC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC", "METACYC"...

[ "3.1.3.-", "PWY-4702", "PWY-5491", "PWY-6148", "PWY-6352", "PWY-6365", "PWY-6366", "PWY-6368", "PWY-6456", "PWY-6575", "PWY-6627", "PWY-6664", "PWY-6686", "PWY-6720", "PWY-6724", "PWY-6955", "PWY-6990", "PWY-6991", "PWY-7018", "PWY-7119", "PWY-7321", "PWY-7531", "PWY-7771...

[ "EC:3.1.3.-", "METACYC:PWY-4702", "METACYC:PWY-5491", "METACYC:PWY-6148", "METACYC:PWY-6352", "METACYC:PWY-6365", "METACYC:PWY-6366", "METACYC:PWY-6368", "METACYC:PWY-6456", "METACYC:PWY-6575", "METACYC:PWY-6627", "METACYC:PWY-6664", "METACYC:PWY-6686", "METACYC:PWY-6720", "METACYC:PWY-6...

36

[ "2bzb", "2c0s" ]

2

[ "PUB00039815", "PUB00077067", "PUB00077068" ]

[ "17001075", "18045868", "15057450" ]

[ "Structural characterization of Spo0E-like protein-aspartic acid phosphatases that regulate sporulation in bacilli.", "Functional role for a conserved aspartate in the Spo0E signature motif involved in the dephosphorylation of the Bacillus subtilis sporulation regulator Spo0A.", "AbrB and Spo0E control the prop...

[ 2006, 2008, 2004 ]

3

[]

0

null

[ "Bacteria", "Caudoviricetes", "Physcomitrium patens", "bioreactor metagenome" ]

[ 7275, 10, 1, 17 ]

4

[]

0

true

Family

Aspartyl-phosphate phosphatase Spo0E-like

Spo0E-like

8

IPR018541

18,541

FtsK gamma domain

Ftsk_gamma

Domain

31,619

false

This domain directs oriented DNA translocation and forms a winged helix structure [ ]. Mutated proteins with substitutions in the FtsK gamma DNA-recognition helix are impaired in DNA binding [ ].

[]

0

[ "PFAM", "SMART" ]

[ "PF09397", "SM00843" ]

[ "FtsK_gamma", "Ftsk_gamma" ]

[ 31570, 31589 ]

2

[]

0

[ "2ius", "2iut", "2j5o", "2j5p", "2ve8", "2ve9", "5dcf" ]

7

[ "PUB00041884" ]

[ "17057717" ]

[ "The FtsK gamma domain directs oriented DNA translocation by interacting with KOPS." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Caudoviricetes", "Eukaryota", "unclassified sequences", "uncultured marine thaumarchaeote KM3_68_B04" ]

[ 30910, 51, 59, 598, 1 ]

5

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Domain

FtsK gamma domain

Ftsk_gamma

3

IPR018542

18,542

Protein 9b, Betacoronavirus

Protein_9b_Betacoronavirus

Family

69

false

This is a family of proteins found in SARS and SARS-like coronaviruses. It includes Protein 9b from SARS coronavirus 2 (SARS-CoV-2), Human SARS coronavirus (SARS-CoV) and Bat coronaviruses. Protein 9b is one of 8 accessory proteins in SARS-CoV [ ]. The gene (ORF 9b, also known as ORF13) that encodes this protein is inc...

[]

0

[ "PFAM", "PROFILE", "CDD" ]

[ "PF09399", "PS51920", "cd21955" ]

[ "bCoV_lipid_BD", "SARS_9B", "SARS-CoV_ORF9b" ]

[ 69, 69, 68 ]

3

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-168928", "R-HSA-9679504", "R-HSA-9692916", "R-HSA-9705671", "R-HSA-9727281" ]

[ "REACTOME:R-HSA-168928", "REACTOME:R-HSA-9679504", "REACTOME:R-HSA-9692916", "REACTOME:R-HSA-9705671", "REACTOME:R-HSA-9727281" ]

5

[ "2cme", "6z4u", "7dhg", "7kdt", "7ye7", "7ye8", "9mzb", "9n55" ]

8

[ "PUB00040066", "PUB00094090", "PUB00094091", "PUB00094092", "PUB00094102", "PUB00094103", "PUB00094110", "PUB00094111" ]

[ "16843897", "30081579", "29895192", "25135833", "19394665", "21637748", "15878679", "17448558" ]

[ "The crystal structure of ORF-9b, a lipid binding protein from the SARS coronavirus.", "Suppression of NF-κB Activity: A Viral Immune Evasion Mechanism.", "Viral strategies for triggering and manipulating mitophagy.", "SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria...

[ 2006, 2018, 2018, 2014, 2009, 2011, 2005, 2007 ]

8

[]

0

null

[ "Betacoronavirus pandemicum" ]

[ 69 ]

1

[]

0

true

Family

Protein 9b, Betacoronavirus

Protein_9b_Betacoronavirus

7

IPR018543

18,543

Adhesion protein FadA

Adhesion_FadA

Family

309

false

FadA (Fusobacterium adhesin A) is an adhesin which forms two α helices.

[]

0

[ "PFAM" ]

[ "PF09403" ]

[ "FadA" ]

[ 309 ]

1

[]

0

[ "2gl2", "3etw", "3etx", "3ety", "3etz" ]

5

[]

0

[]

0

null

[ "Agaricomycetes", "Fusobacteriales" ]

[ 21, 288 ]

2

[]

0

true

Family

Adhesion protein FadA

Adhesion_FadA

3

IPR018544

18,544

KICSTOR subunit 2

KICS_2

Family

1,775

false

This entry includes KICSTOR subunit 2 (KICS2, also known as C12orf66-like) proteins. Human KICS2 is part of the KICSTOR complex that functions in the amino acid-sensing branch of the TORC1 signalling pathway [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09404", "PTHR31581" ]

[ "C12orf66_like", "" ]

[ 1758, 1734 ]

2

[ "GP", "REACTOME", "REACTOME" ]

[ "GenProp2026", "R-HSA-9639288", "R-MMU-9639288" ]

[ "GP:GenProp2026", "REACTOME:R-HSA-9639288", "REACTOME:R-MMU-9639288" ]

3

[ "2gnx", "9v6e", "9v86", "9v9n", "9van" ]

5

[ "PUB00085648" ]

[ "28199306" ]

[ "KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1." ]

[ 2017 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1775 ]

1

[ "Danio rerio", "Homo sapiens", "Mus musculus", "Rattus norvegicus" ]

[ 4, 3, 2, 4 ]

4

true

Family

KICSTOR subunit 2

KICS_2

2

IPR018545

18,545

Btz domain

Btz_dom

Domain

5,082

false

This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein, also known as MLN51) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the assoc...

[ "GO:0003729", "GO:0006397", "GO:0035145" ]

[ "mRNA binding", "mRNA processing", "exon-exon junction complex" ]

[ "molecular_function", "biological_process", "cellular_component" ]

3

[ "PFAM", "SMART" ]

[ "PF09405", "SM01044" ]

[ "Btz", "Btz" ]

[ 5002, 3984 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-159236", "R-BTA-72163", "R-BTA-72187", "R-BTA-73856", "R-BTA-975957", "R-DRE-72163", "R-DRE-975957", "R-HSA-159236", "R-HSA-72163", "R-HSA-72187", "R-HSA-73856", "R-HSA-9010553", "R-HSA-975957", "R-MMU-159236", "R-MMU-72163", "R-MMU-72187", "R-MMU-73856", "R-MMU-975957", "...

[ "REACTOME:R-BTA-159236", "REACTOME:R-BTA-72163", "REACTOME:R-BTA-72187", "REACTOME:R-BTA-73856", "REACTOME:R-BTA-975957", "REACTOME:R-DRE-72163", "REACTOME:R-DRE-975957", "REACTOME:R-HSA-159236", "REACTOME:R-HSA-72163", "REACTOME:R-HSA-72187", "REACTOME:R-HSA-73856", "REACTOME:R-HSA-9010553", ...

25

[ "2hyi", "2j0q", "2j0s", "2j0u", "2xb2", "3ex7", "5xjc", "5yzg", "6icz", "7w59", "7w5a", "7w5b", "8i0w" ]

13

[ "PUB00041837", "PUB00044176" ]

[ "16923391", "14973490" ]

[ "The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA.", "An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay." ]

[ 2006, 2004 ]

2

[]

0

null

[ "Eukaryota" ]

[ 5082 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Zea mays" ]

[ 15, 1, 1, 5, 6, 2, 1, 12, 7, 23 ]

10

true

Domain

Btz domain

Btz_dom

9

IPR018546

18,546

Domain of unknown function DUF2004

DUF2004

Domain

14

false

This is entry represents a domain of unknown function in archaeal proteins. The structure of one of the proteins in this family has revealed a novel α-β fold [ ].

[]

0

[ "PFAM" ]

[ "PF09406" ]

[ "DUF2004" ]

[ 14 ]

1

[]

0

[ "2aby" ]

1

[ "PUB00039229" ]

[ "16374782" ]

[ "NMR structure of the conserved novel-fold protein TA0743 from Thermoplasma acidophilum." ]

[ 2006 ]

1

[]

0

null

[ "Thermoplasmata", "mine drainage metagenome" ]

[ 13, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF2004

DUF2004

6

IPR018548

18,548

Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus

Spike_S1_RBD_bCoV

Domain

3,718

false

The CoV Spike (S) protein is an envelope glycoprotein that plays the most important role in viral attachment, fusion, and entry into host cells, and serves as a major target for the development of neutralizing antibodies, inhibitors of viral entry, and vaccines. It is synthesised as a precursor protein that is cleaved ...

[]

0

[ "PFAM", "PROFILE" ]

[ "PF09408", "PS51921" ]

[ "bCoV_S1_RBD", "BCOV_S1_CTD" ]

[ 3111, 3637 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-9678110", "R-HSA-9679509", "R-HSA-9683686", "R-HSA-9683701", "R-HSA-9692916", "R-HSA-9694322", "R-HSA-9694548", "R-HSA-9694614", "R-HSA-9694635", "R-HSA-9705671", "R-HSA-9733458" ]

[ "REACTOME:R-HSA-9678110", "REACTOME:R-HSA-9679509", "REACTOME:R-HSA-9683686", "REACTOME:R-HSA-9683701", "REACTOME:R-HSA-9692916", "REACTOME:R-HSA-9694322", "REACTOME:R-HSA-9694548", "REACTOME:R-HSA-9694614", "REACTOME:R-HSA-9694635", "REACTOME:R-HSA-9705671", "REACTOME:R-HSA-9733458" ]

11

[ "2ajf", "2dd8", "2ghv", "2ghw", "3bgf", "3d0g", "3d0h", "3d0i", "3jcl", "3sci", "3scj", "3sck", "3scl", "4kqz", "4kr0", "4l3n", "4l72", "4qzv", "4xak", "4zpt", "4zpv", "4zpw", "4zs6", "5do2", "5gmq", "5gnb", "5gyq", "5i08", "5kwb", "5w9h", "5w9i", "5w9j"...

2,322

[ "PUB00040219", "PUB00076411", "PUB00093736", "PUB00094114", "PUB00094414", "PUB00095908", "PUB00095927", "PUB00095928", "PUB00097564" ]

[ "16597622", "26085157", "27696819", "32150576", "27578435", "29500692", "32225175", "32225176", "32203189" ]

[ "Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody.", "Identification of the Receptor-Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1.", "Putative Receptor Binding Domain of Bat-Derived Coronavirus HKU9 Spike Protein: E...

[ 2006, 2015, 2016, 2020, 2016, 2018, 2020, 2020, 2020 ]

9

[]

[ "IPR044364", "IPR044366", "IPR044370", "IPR044372", "IPR044375", "IPR044376", "IPR044378", "IPR044380" ]

0

8

0

[ "Orthornavirae" ]

[ 3718 ]

1

[]

0

true

Domain

Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus

Spike_S1_RBD_bCoV

8

IPR018550

18,550

Lipid A 3-O-deacylase-related

Lipid-A_deacylase-rel

Family

6,869

false

PagL is an outer membrane protein with lipid A 3-O-deacylase activity. It forms an 8 stranded β barrel structure [ ].

[]

0

[ "PFAM", "PIRSF" ]

[ "PF09411", "PIRSF029681" ]

[ "PagL", "PagL" ]

[ 6869, 2035 ]

2

[]

0

[ "2erv" ]

1

[ "PUB00044418" ]

[ "16632613" ]

[ "Crystal structure and catalytic mechanism of the LPS 3-O-deacylase PagL from Pseudomonas aeruginosa." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Eukaryota", "Halorubrum tibetense", "unclassified sequences", "uncultured Caudovirales phage" ]

[ 6760, 8, 1, 99, 1 ]

5

[]

0

true

Family

Lipid A 3-O-deacylase-related

Lipid-A_deacylase-rel

1

IPR018552

18,552

Centromere protein X

CENP-X

Family

2,813

false

Centromere protein X (CENP-X) is a component of several different complexes, including the multisubunit FA complex, the heterotetrameric CENP-T-W-S-X complex and the APITD1/CENPS complex.

[ "GO:0006281", "GO:0051382" ]

[ "DNA repair", "kinetochore assembly" ]

[ "biological_process", "biological_process" ]

2

[ "PFAM", "PANTHER" ]

[ "PF09415", "PTHR28680" ]

[ "CENP-X", "" ]

[ 2794, 2545 ]

2

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-BTA-606279", "R-BTA-6783310", "R-BTA-9833482", "R-HSA-606279", "R-HSA-6783310", "R-HSA-9833482", "R-MMU-606279", "R-MMU-6783310", "R-MMU-9833482" ]

[ "REACTOME:R-BTA-606279", "REACTOME:R-BTA-6783310", "REACTOME:R-BTA-9833482", "REACTOME:R-HSA-606279", "REACTOME:R-HSA-6783310", "REACTOME:R-HSA-9833482", "REACTOME:R-MMU-606279", "REACTOME:R-MMU-6783310", "REACTOME:R-MMU-9833482" ]

9

[ "3b0b", "3v9r", "3vh5", "3vh6", "4dra", "4drb", "4e44", "4e45", "4ndy", "4ne1", "4ne3", "4ne5", "4ne6", "7da0", "7da1", "7da2", "7r5s", "7xhn", "7xho", "7ywx" ]

20

[ "PUB00054164", "PUB00054178", "PUB00054179", "PUB00058268", "PUB00085161" ]

[ "19620631", "20347428", "20347429", "22304917", "22723423" ]

[ "The CENP-S complex is essential for the stable assembly of outer kinetochore structure.", "A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.", "MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM.", "C...

[ 2009, 2010, 2010, 2012, 2012 ]

5

[]

0

null

[ "Eukaryota" ]

[ 2813 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "S...

[ 7, 1, 1, 4, 2, 1, 3, 5, 1, 1, 3 ]

11

true

Family

Centromere protein X

CENP-X

6

IPR018553

18,553

Non-canonical E2 ubiquitin-conjugating enzyme

E2_Ub-conjug_enz

Family

1,327

false

This entry describes a family of non-canonical E2 ubiquitin-conjugating proteins that lack the typical HPN motif characteristic of conventional E2 enzymes, including from Plasmodium falciparum and similar proteins mainly from in Apicomplexan parasites, fungi and some amoeba species. These proteins show a C-terminal dom...

[]

0

[ "PANTHER" ]

[ "PTHR31560" ]

[ "" ]

[ 1327 ]

1

[]

0

[]

0

[ "PUB00160741" ]

[ "40249735" ]

[ "Activity-based protein profiling reveals both canonical and novel ubiquitin pathway enzymes in Plasmodium." ]

[ 2025 ]

1

[]

0

null

[ "Eukaryota", "uncultured organism MedDCM-OCT-S04-C2" ]

[ 1326, 1 ]

2

[ "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2 ]

1

true

Family

Non-canonical E2 ubiquitin-conjugating enzyme

E2_Ub-conjug_enz

7

IPR018554

18,554

Frequency clock protein

FRQ

Family

1,090

false

This entry represents Frequency clock protein, Primary circadian oscillator component FRQ1, Circadian oscillator component FRQ10 and related fungal proteins. Frequency (FRQ) is a key circadian clock component that is involved in the generation of biological rhythms in Neurospora crassa [ ]. It plays a role in rhythm st...

[ "GO:0006355", "GO:0007623", "GO:0005634", "GO:0005737" ]

[ "regulation of DNA-templated transcription", "circadian rhythm", "nucleus", "cytoplasm" ]

[ "biological_process", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PFAM" ]

[ "PF09421" ]

[ "FRQ" ]

[ 1090 ]

1

[]

0

[]

0

[ "PUB00044273", "PUB00044985", "PUB00056621", "PUB00163261", "PUB00163264" ]

[ "11226160", "6455327", "19141472", "40153515", "20361495" ]

[ "Coiled-coil domain-mediated FRQ-FRQ interaction is essential for its circadian clock function in Neurospora.", "The frq locus in Neurospora crassa: a key element in circadian clock organization.", "Circadian activity and abundance rhythms of the Neurospora clock transcription factor WCC associated with rapid n...

[ 2001, 1980, 2008, 2025, 2010 ]

5

[]

0

null

[ "Eukaryota" ]

[ 1090 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)" ]

[ 1 ]

1

true

Family

Frequency clock protein

FRQ

2

IPR018555

18,555

C630.06c-like

Family

1,285

false

This protein family includes the uncharacterised nucleolar protein C630.06c from Schizosaccharomyces pombe and similar fungal proteins. C630.06c is an orthologue of the conserved eukaryotic protein Custos, implicated in cell growth or cell division [ , ].

[]

0

[ "PFAM" ]

[ "PF09428" ]

[ "DUF2011" ]

[ 1285 ]

1

[]

0

[]

0

[ "PUB00160733", "PUB00160734" ]

[ "23697806", "29996109" ]

[ "A genome-wide resource of cell cycle and cell shape genes of fission yeast.", "Quantitative Phosphoproteomics Reveals the Signaling Dynamics of Cell-Cycle Kinases in the Fission Yeast Schizosaccharomyces pombe." ]

[ 2013, 2018 ]

2

[]

0

null

[ "Fungi" ]

[ 1285 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

C630.06c-like

1

IPR018556

18,556

SPIN90/Ldb17, leucine-rich domain

SPIN90/Ldb17_LRD

Domain

3,587

false

This is the conserved leucine-rich domain (LRD) within the C-terminal domain of SPIN90 (also known as NCK interacting protein with SH3 domain (NCKIPSD)) from animals, Ldb17 from budding yeasts and Dip1 from fission yeasts [ ]. Ldb17 is involved in the regulation of endocytosis in yeast [ ]. SPIN90 is an F-actin binding...

[]

0

[ "PFAM" ]

[ "PF09431" ]

[ "SPIN90_LRD" ]

[ 3587 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-2029482", "R-HSA-5663213", "R-HSA-9664422", "R-MMU-2029482", "R-MMU-5663213" ]

[ "REACTOME:R-HSA-2029482", "REACTOME:R-HSA-5663213", "REACTOME:R-HSA-9664422", "REACTOME:R-MMU-2029482", "REACTOME:R-MMU-5663213" ]

5

[ "6dec", "6ded", "6dee", "6w17", "9i2b", "9m5e", "9m64" ]

7

[ "PUB00033588", "PUB00054166", "PUB00054167", "PUB00085468", "PUB00098231" ]

[ "16253999", "19506040", "11157975", "17453829", "30322896" ]

[ "Interaction of SPIN90 with the Arp2/3 complex mediates lamellipodia and actin comet tail formation.", "Regulators of yeast endocytosis identified by systematic quantitative analysis.", "A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent...

[ 2006, 2009, 2001, 2007, 2018 ]

5

[]

0

null

[ "Eukaryota", "Olivibacter domesticus" ]

[ 3586, 1 ]

2

[ "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strai...

[ 1, 1, 1, 2, 1, 1, 2, 1, 1 ]

9

true

Domain

SPIN90/Ldb17, leucine-rich domain

SPIN90/Ldb17_LRD

6

IPR018560

18,560

Domain of unknown function DUF2016

DUF2016

Domain

294

false

This entry represents the N-terminal of proteins that contain a ubiquitin domain mainly found in bacteria. This domain is usually found associated with .

[]

0

[ "PFAM" ]

[ "PF09436" ]

[ "DUF2016" ]

[ 294 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Pseudomonadati", "Ralstonia phage Dina", "ecological metagenomes" ]

[ 289, 1, 4 ]

3

[]

0

true

Domain

Domain of unknown function DUF2016

DUF2016

2

IPR018562

18,562

ARS binding protein 2

ARS-binding_2

Family

1,071

false

This DNA-binding protein binds to the autonomously replicating sequence (ARS) binding element. It may play a role in regulating the cell cycle response to stress signals [ ].

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09441", "PTHR42048" ]

[ "Abp2", "" ]

[ 1063, 1047 ]

2

[]

0

[]

0

[ "PUB00044134" ]

[ "9488484" ]

[ "Isolation, characterization, and molecular cloning of a protein (Abp2) that binds to a Schizosaccharomyces pombe origin of replication (ars3002)." ]

[ 1998 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1071 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1 ]

2

true

Family

ARS binding protein 2

ARS-binding_2

3

IPR018564

18,564

DNA replication checkpoint mediator, MRC1 domain

Repl_chkpnt_MRC1_dom

Domain

1,751

false

This putative domain is found in the most conserved region in mediator of replication checkpoint protein 1. This protein is a component of the replisome and is required for Rad3-dependent activation of the checkpoint kinase Cds1 in response to replication fork arrest [ ].

[]

0

[ "PFAM" ]

[ "PF09444" ]

[ "MRC1" ]

[ 1751 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-SCE-176187", "R-SCE-5689880", "R-SPO-176187", "R-SPO-5689880" ]

[ "REACTOME:R-SCE-176187", "REACTOME:R-SCE-5689880", "REACTOME:R-SPO-176187", "REACTOME:R-SPO-5689880" ]

4

[ "8b9a", "8b9b", "8b9c", "8xgc" ]

4

[ "PUB00054174" ]

[ "14585996" ]

[ "Replication checkpoint protein Mrc1 is regulated by Rad3 and Tel1 in fission yeast." ]

[ 2003 ]

1

[]

0

null

[ "Eukaryota" ]

[ 1751 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Domain

DNA replication checkpoint mediator, MRC1 domain

Repl_chkpnt_MRC1_dom

4

IPR018565

18,565

Kinetochore subunit Nkp2/Cnl2

Nkp2/Cnl2

Family

1,016

false

This entry includes the inner kinetochore subunit Cnl2 from fission yeasts [ ] and Nkp2 from budding yeasts [ ].

[ "GO:0000776" ]

[ "kinetochore" ]

[ "cellular_component" ]

1

[ "PFAM", "PANTHER" ]

[ "PF09447", "PTHR28064" ]

[ "Cnl2_NKP2", "" ]

[ 1009, 976 ]

2

[]

0

[ "6nuw", "6qld", "6qle", "6qlf", "8ovw", "8ovx", "8ow0", "8ow1" ]

8

[ "PUB00044201", "PUB00067771" ]

[ "17035632", "22561346" ]

[ "Reconstruction of the kinetochore during meiosis in fission yeast Schizosaccharomyces pombe.", "CENP-T proteins are conserved centromere receptors of the Ndc80 complex." ]

[ 2006, 2012 ]

2

[]

0

null

[ "Eukaryota" ]

[ 1016 ]

1

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 1, 1, 1 ]

3

true

Family

Kinetochore subunit Nkp2/Cnl2

Nkp2/Cnl2

7

IPR018566

18,566

4-Methylmuconolactone methyl-isomerase

MeMu_Me-Isoase

Domain

45

false

4-methylmuconolactone methyl-isomerase (MmlI), also known as 4-carboxymethyl-4-methylbutenolide mutase, is a short, approx 115 residue, protein of two α helices and four β strands. It is involved in the catabolism of methyl-substituted aromatics via a modified oxo-adipate pathway in bacteria. The enzyme appears to be m...

[]

0

[ "PFAM" ]

[ "PF09448" ]

[ "MmlI" ]

[ 45 ]

1

[]

0

[ "2ifx", "3hds", "3hf5", "3hfk" ]

4

[ "PUB00044368", "PUB00044369" ]

[ "2241929", "2818569" ]

[ "Purification and characterization of 4-methylmuconolactone methylisomerase, a novel enzyme of the modified 3-oxoadipate pathway in the gram-negative bacterium Alcaligenes eutrophus JMP 134.", "Purification and characterization of 4-methylmuconolactone methyl-isomerase, a novel enzyme of the modified 3-oxoadipate...

[ 1990, 1989 ]

2

[]

0

null

[ "Pseudomonadota" ]

[ 45 ]

1

[]

0

true

Domain

4-Methylmuconolactone methyl-isomerase

MeMu_Me-Isoase

3

IPR018567

18,567

Domain of unknown function DUF2020

DUF2020

Domain

410

false

Protein of unknown function found in bacteria.

[]

0

[ "PFAM" ]

[ "PF09449" ]

[ "DUF2020" ]

[ 410 ]

1

[]

0

[ "3v7b" ]

1

[]

0

[]

0

null

[ "Actinomycetes", "freshwater metagenome" ]

[ 409, 1 ]

2

[]

0

true

Domain

Domain of unknown function DUF2020

DUF2020

3

IPR018568

18,568

Domain of unknown function DUF2019

DUF2019

Domain

311

false

Protein of unknown function found in bacteria.

[]

0

[ "PFAM" ]

[ "PF09450" ]

[ "DUF2019" ]

[ 311 ]

1

[]

0

[ "2i9c" ]

1

[]

0

[]

0

null

[ "Bacteria", "marine sediment metagenome" ]

[ 307, 4 ]

2

[]

0

true

Domain

Domain of unknown function DUF2019

DUF2019

5

IPR018569

18,569

Saf-pilin pilus formation protein

Saf-pilin_pilus_formation

Domain

1,056

false

This domain consists of the adjacent Saf-Nte and Saf-pilin chains of the pilus-forming complex. Pilus assembly in Gram-negative bacteria involves a Donor-strand exchange mechanism between the C- and the N-termini of this domain. The C-terminal subunit forms an incomplete Ig-fold which is then complemented by the 10-18 ...

[]

0

[ "NCBIFAM", "PFAM", "CDD" ]

[ "NF011767", "PF09460", "cd18775" ]

[ "PRK15221.1", "Saf-Nte_pilin", "SafA-like" ]

[ 995, 1054, 1025 ]

3

[]

0

[ "2cny", "2cnz", "2co1", "2co2", "2co3", "2co4", "2co6", "2co7", "3cre", "3crf", "5y9g", "5y9h" ]

12

[ "PUB00040079" ]

[ "16793551" ]

[ "Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism." ]

[ 2006 ]

1

[]

0

null

[ "Gammaproteobacteria" ]

[ 1056 ]

1

[]

0

true

Domain

Saf-pilin pilus formation protein

Saf-pilin_pilus_formation

7

IPR018570

18,570

Phytotoxin, PcF

Phytotoxin_PcF

Domain

100

false

PcF is a 52 residue protein factor of two α helices, containing a 4-hydroxyproline and three cysteine bridges. The presence of the hydroxyproline is unique in relation to other fungal phytotoxic proteins. The protein has a high content of acidic side-chains implying a lack of binding with lipid-rich components of membr...

[]

0

[ "PFAM" ]

[ "PF09461" ]

[ "PcF" ]

[ 100 ]

1

[]

0

[ "2bic" ]

1

[]

0

[]

0

null

[ "Peronosporaceae" ]

[ 100 ]

1

[]

0

true

Domain

Phytotoxin, PcF

Phytotoxin_PcF

2

IPR018571

18,571

Membrane anchor Opy2, N-terminal

Membrane_anchor_Opy2_N

Domain

1,253

false

Opy2p acts as a membrane anchor in the HOG signalling pathway [ ]. This entry represents a conserved N-terminal domain.

[]

0

[ "PFAM" ]

[ "PF09463" ]

[ "Opy2" ]

[ 1253 ]

1

[]

0

[]

0

[ "PUB00044414" ]

[ "16543225" ]

[ "Adaptor protein Ste50p links the Ste11p MEKK to the HOG pathway through plasma membrane association." ]

[ 2006 ]

1

[]

0

null

[ "Caldalkalibacillus horti", "Eukaryota" ]

[ 1, 1252 ]

2

[ "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)" ]

[ 1, 1 ]

2

true

Domain

Membrane anchor Opy2, N-terminal

Membrane_anchor_Opy2_N

5

IPR018572

18,572

Protein of unknown function YopT

YopT

Family

18

false

The function of the YopT protein is not known, though it has been structurally characterised. The protein is a homo-dimer, with each monomer consisting of one α helix and three β strands.

[]

0

[ "PFAM" ]

[ "PF09467" ]

[ "Yopt" ]

[ 18 ]

1

[]

0

[ "2dlb" ]

1

[]

0

[]

0

null

[ "Bacillus", "Bacillus phage SPbeta" ]

[ 17, 1 ]

2

[]

0

true

Family

Protein of unknown function YopT

YopT

3

IPR018573

18,573

Restriction endonuclease, type II, AlwI

Restrct_endonuc_II_AlwI

Family

641

false

There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit compositi...

[]

0

[ "PFAM" ]

[ "PF09491" ]

[ "RE_AlwI" ]

[ 641 ]

1

[]

0

[ "2ewf", "2p14", "5lhc", "5liq", "5liz", "6qnz" ]

6

[ "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707" ]

[ "15770420", "14576294", "11827971", "11557805", "15121719", "12665693" ]

[ "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between different subgroups of restriction endonucleases.", "Structure and function of type II restriction endonucleases.", "S-A...

[ 2005, 2003, 2002, 2001, 2004, 2003 ]

6

[]

0

null

[ "Archaea", "Bacteria", "Glomus cerebriforme", "Siphoviridae sp. ctLKT1", "metagenomes" ]

[ 3, 623, 1, 1, 13 ]

5

[]

0

true

Family

Restriction endonuclease, type II, AlwI

Restrct_endonuc_II_AlwI

2

IPR018574

18,574

Structure-specific endonuclease subunit Slx4, HTH domain

Slx4_HTH

Domain

2,918

false

The Slx4 protein is a heteromeric structure-specific endonuclease found from fungi to mammals. Slx4 is a regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination [ , ]. The SLX1-SLX4 complex has a preference for 5'-flap stru...

[ "GO:0006260", "GO:0006281", "GO:0005634", "GO:0033557" ]

[ "DNA replication", "DNA repair", "nucleus", "Slx1-Slx4 complex" ]

[ "biological_process", "biological_process", "cellular_component", "cellular_component" ]

4

[ "PFAM" ]

[ "PF09494" ]

[ "Slx4" ]

[ 2918 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME" ]

[ "R-HSA-5693568", "R-HSA-6783310", "R-MMU-5693568", "R-MMU-6783310" ]

[ "REACTOME:R-HSA-5693568", "REACTOME:R-HSA-6783310", "REACTOME:R-MMU-5693568", "REACTOME:R-MMU-6783310" ]

4

[ "4xlg", "4zdt", "6seh", "6sei", "7cq2", "7cq3", "7cq4" ]

7

[ "PUB00044490", "PUB00053134", "PUB00053520", "PUB00066667", "PUB00066672", "PUB00066673" ]

[ "12832395", "19596236", "18471978", "19595721", "21240277", "21240275" ]

[ "Slx1-Slx4 is a second structure-specific endonuclease functionally redundant with Sgs1-Top3.", "Human SLX4 is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases.", "Microarray-based genetic screen defines SAW1, a gene required for Rad1/Rad10-dependent processing of...

[ 2003, 2009, 2008, 2009, 2011, 2011 ]

6

[]

0

null

[ "Eukaryota" ]

[ 2918 ]

1

[ "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Rattus norvegicus", "Saccharomyces cerevisiae (strain ATCC 204508 / S288c)", "Schizosaccharomyces pombe (strain 972 / ATCC 24843)" ]

[ 2, 3, 1, 4, 1, 2, 1, 1 ]

8

true

Domain

Structure-specific endonuclease subunit Slx4, HTH domain

Slx4_HTH

4

IPR018575

18,575

Restriction endonuclease, type II, Eco29kI, GIY-YIG domain

GYI-YIG_Eco29kI

Domain

474

false

There are four classes of restriction endonucleases: types I, II, III and IV. All types of enzymes recognise specific short DNA sequences and carry out the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates. They differ in their recognition sequence, subunit compositi...

[]

0

[ "PFAM" ]

[ "PF09517" ]

[ "RE_Eco29kI" ]

[ 474 ]

1

[]

0

[ "3mx1", "3mx4", "3nic" ]

3

[ "PUB00035691", "PUB00035692", "PUB00035693", "PUB00035694", "PUB00035705", "PUB00035707", "PUB00058813" ]

[ "15770420", "14576294", "11827971", "11557805", "15121719", "12665693", "20800503" ]

[ "Type II restriction endonucleases: structure and mechanism.", "Diversity of type II restriction endonucleases that require two DNA recognition sites.", "Evolutionary relationship between different subgroups of restriction endonucleases.", "Structure and function of type II restriction endonucleases.", "S-A...

[ 2005, 2003, 2002, 2001, 2004, 2003, 2010 ]

7

[]

0

null

[ "Bacteria", "Opisthokonta", "Viruses", "metagenomes" ]

[ 448, 14, 3, 9 ]

4

[]

0

true

Domain

Restriction endonuclease, type II, Eco29kI, GIY-YIG domain

GYI-YIG_Eco29kI

5

IPR018576

18,576

Restriction endonuclease, type II, Pab1

Restrct_endonuc_II_Pab1

Domain

173

false

This family includes R.Pab1 from Pyrococcus abyssi. R.Pab1 is homodimeric and has a curved anti-parallel β-sheet, which forms a three dimensional shape resembling a 'half pipe' that is responsible for double-strand DNA-binding [ ].

[]

0

[ "PFAM" ]

[ "PF09522" ]

[ "RE_R_Pab1" ]

[ 173 ]

1

[]

0

[ "7cfa" ]

1

[ "PUB00040325" ]

[ "17332011" ]

[ "Novel protein fold discovered in the PabI family of restriction enzymes." ]

[ 2007 ]

1

[]

0

null

[ "Bacteria", "Gigasporaceae", "Thermogladius calderae" ]

[ 170, 2, 1 ]

3

[]

0

true

Domain

Restriction endonuclease, type II, Pab1

Restrct_endonuc_II_Pab1

1

IPR018577

18,577

Restriction endonuclease, type II, Bpu10I

Restrct_endonuc_II_Bpu10I

Family

174

false

This entry includes Bpu10I which recognises and cleaves CCTNAGC (-5/-2)restriction endonucleases.

[]

0

[ "PFAM" ]

[ "PF09549" ]

[ "RE_Bpu10I" ]

[ 174 ]

1

[]

0

[ "6eg7", "6m9g", "6maf", "6mag" ]

4

[]

0

[]

0

null

[ "Bacteria", "Racocetra persica", "marine sediment metagenome" ]

[ 172, 1, 1 ]

3

[]

0

true

Family

Restriction endonuclease, type II, Bpu10I

Restrct_endonuc_II_Bpu10I

8

IPR018579

18,579

Restriction endonuclease, type II, LlaJI

Restrct_endonuc_II_LlaJI

Family

443

false

This entry includes LlaJI which recognises GACGC restriction endonucleases [ ].

[]

0

[ "PFAM" ]

[ "PF09563" ]

[ "RE_LlaJI" ]

[ 443 ]

1

[]

0

[]

0

[ "PUB00045106" ]

[ "16646963" ]

[ "A genetic dissection of the LlaJI restriction cassette reveals insights on a novel bacteriophage resistance system." ]

[ 2006 ]

1

[]

0

null

[ "Bacteria", "Methanobrevibacter", "ecological metagenomes", "unclassified Caudoviricetes" ]

[ 437, 2, 2, 2 ]

4

[]

0

true

Family

Restriction endonuclease, type II, LlaJI

Restrct_endonuc_II_LlaJI

5

IPR018580

18,580

Uncharacterised protein family YfhO

Uncharacterised_YfhO

Family

10,260

false

The yfhO gene is transcribed in Difco sporulation medium and the transcription is affected by the YvrGHb two-component system [ ]. Some members of this family have been annotated as putative ABC transporter permease proteins.

[]

0

[ "PFAM", "PANTHER" ]

[ "PF09586", "PTHR38454" ]

[ "YfhO", "" ]

[ 8950, 10049 ]

2

[]

0

[]

0

[ "PUB00044549" ]

[ "16306698" ]

[ "Functional analysis of the YvrGHb two-component system of Bacillus subtilis: identification of the regulated genes by DNA microarray and northern blot analyses." ]

[ 2005 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota", "Siphoviridae sp. ctBLh2", "metagenomes" ]

[ 8, 10086, 3, 1, 162 ]

5

[]

0

true

Family

Uncharacterised protein family YfhO

Uncharacterised_YfhO

7

IPR018581

18,581

Type III secretion system, pilus formation, HrpA

T3SS_pilus_HrpA

Family

294

false

HrpA is an essential component of the type III secretion system (TTSS) which pathogens use to inject virulence factors directly into their host cells, and to cause disease. The TTSS has an Hrp pilus appendage for channelling effector proteins through the plant cell wall and this pilus elongates by the addition of HrpA ...

[ "GO:0005615" ]

[ "extracellular space" ]

[ "cellular_component" ]

1

[ "PFAM" ]

[ "PF09589" ]

[ "HrpA_pilin" ]

[ 294 ]

1

[]

0

[]

0

[ "PUB00044306" ]

[ "11953310" ]

[ "The Hrp pilus of Pseudomonas syringae elongates from its tip and acts as a conduit for translocation of the effector protein HrpZ." ]

[ 2002 ]

1

[]

0

null

[ "Pseudomonadota" ]

[ 294 ]

1

[]

0

true

Family

Type III secretion system, pilus formation, HrpA

T3SS_pilus_HrpA

3

IPR018582

18,582

Envelope glycoprotein, lentivirus

Envelope_glycop_lentivirus

Family

1,691

false

The proteins in this family are envelope glycoproteins from feline immunodeficiency retrovirus. The process of lentiviral envelope glycoprotein-mediated fusion of membranes is essential for viral entry and syncytia formation [ ].

[]

0

[ "PFAM" ]

[ "PF09590" ]

[ "Env-gp36" ]

[ 1691 ]

1

[]

0

[]

0

[ "PUB00044248" ]

[ "15051387" ]

[ "Mechanism of feline immunodeficiency virus envelope glycoprotein-mediated fusion." ]

[ 2004 ]

1

[]

0

null

[ "Lentivirus" ]

[ 1691 ]

1

[]

0

true

Family

Envelope glycoprotein, lentivirus

Envelope_glycop_lentivirus

8